NPM1P33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.39810784
2cytidine deamination (GO:0009972)4.99670888
3cytidine metabolic process (GO:0046087)4.99670888
4cytidine catabolic process (GO:0006216)4.99670888
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.74205472
6proteasome assembly (GO:0043248)4.39393185
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26080784
8pyrimidine ribonucleoside catabolic process (GO:0046133)4.19153243
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.04595387
10ATP synthesis coupled proton transport (GO:0015986)4.04595387
11establishment of protein localization to mitochondrial membrane (GO:0090151)3.90383997
12protein neddylation (GO:0045116)3.79743735
13nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.59559095
14exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.56759393
15respiratory chain complex IV assembly (GO:0008535)3.55965844
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.54718793
17rRNA modification (GO:0000154)3.53491671
18water-soluble vitamin biosynthetic process (GO:0042364)3.51536120
19platelet dense granule organization (GO:0060155)3.46214965
20response to pheromone (GO:0019236)3.44480425
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40551128
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40551128
23regulation of cellular amino acid metabolic process (GO:0006521)3.38628725
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36026185
25protein complex biogenesis (GO:0070271)3.25325044
26chaperone-mediated protein transport (GO:0072321)3.25161986
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20604560
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16444502
29signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16444502
30signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16444502
31DNA demethylation (GO:0080111)3.15882708
32mitochondrial respiratory chain complex assembly (GO:0033108)3.10673747
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10603346
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10148800
35cytochrome complex assembly (GO:0017004)3.09645438
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09566049
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09566049
38electron transport chain (GO:0022900)3.07650764
39respiratory electron transport chain (GO:0022904)3.07618074
40positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.03873158
41RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02520159
42mitochondrial respiratory chain complex I assembly (GO:0032981)2.99790982
43NADH dehydrogenase complex assembly (GO:0010257)2.99790982
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99790982
45signal transduction involved in cell cycle checkpoint (GO:0072395)2.98781211
46negative regulation of ligase activity (GO:0051352)2.98083218
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98083218
48signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96552449
49signal transduction involved in DNA damage checkpoint (GO:0072422)2.96552449
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93712386
51regulation of isotype switching to IgG isotypes (GO:0048302)2.93360103
52pseudouridine synthesis (GO:0001522)2.92321948
53DNA double-strand break processing (GO:0000729)2.90562639
54preassembly of GPI anchor in ER membrane (GO:0016254)2.87690374
55chromatin remodeling at centromere (GO:0031055)2.86244145
56GPI anchor metabolic process (GO:0006505)2.84500527
57positive regulation of defense response to virus by host (GO:0002230)2.83040168
58regulation of regulatory T cell differentiation (GO:0045589)2.82855593
59CENP-A containing nucleosome assembly (GO:0034080)2.80813757
60rRNA methylation (GO:0031167)2.80390183
61transcription elongation from RNA polymerase III promoter (GO:0006385)2.79998414
62termination of RNA polymerase III transcription (GO:0006386)2.79998414
63kynurenine metabolic process (GO:0070189)2.79511915
64GPI anchor biosynthetic process (GO:0006506)2.79023212
65mannosylation (GO:0097502)2.77337824
66tryptophan catabolic process (GO:0006569)2.76802733
67indole-containing compound catabolic process (GO:0042436)2.76802733
68indolalkylamine catabolic process (GO:0046218)2.76802733
69negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.75012908
70regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.74179190
71amino acid salvage (GO:0043102)2.73898521
72L-methionine salvage (GO:0071267)2.73898521
73L-methionine biosynthetic process (GO:0071265)2.73898521
74regulation of chronic inflammatory response (GO:0002676)2.73590122
75negative regulation of mast cell activation (GO:0033004)2.73110828
76negative regulation of T cell apoptotic process (GO:0070233)2.72373028
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68155774
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68106983
79positive regulation of interleukin-17 production (GO:0032740)2.67713796
80positive regulation of protein homodimerization activity (GO:0090073)2.67517736
81DNA catabolic process, exonucleolytic (GO:0000738)2.62312586
82negative regulation of calcium ion transport into cytosol (GO:0010523)2.62305279
83DNA dealkylation (GO:0035510)2.61535582
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.56443521
85negative regulation by host of viral transcription (GO:0043922)2.56313507
86signal peptide processing (GO:0006465)2.56236055
87protein deneddylation (GO:0000338)2.55429180
88positive regulation of ligase activity (GO:0051351)2.53267622
89indolalkylamine metabolic process (GO:0006586)2.51506903
90ATP biosynthetic process (GO:0006754)2.48433080
91negative regulation of thymocyte apoptotic process (GO:0070244)2.47756109
92aldehyde catabolic process (GO:0046185)2.47471880
93histone mRNA metabolic process (GO:0008334)2.47210398
94tRNA processing (GO:0008033)2.45295557
95regulation of immunoglobulin secretion (GO:0051023)2.45211155
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.44519235
97purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.44095555
98DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.43515835
99purine nucleoside triphosphate biosynthetic process (GO:0009145)2.43341519
100positive regulation of cell cycle arrest (GO:0071158)2.42936419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.12922312
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.77094838
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.52765522
4VDR_22108803_ChIP-Seq_LS180_Human3.17272050
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.05415987
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.00538743
7ZNF274_21170338_ChIP-Seq_K562_Hela2.94152184
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62576938
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.49139860
10VDR_23849224_ChIP-Seq_CD4+_Human2.31139075
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29805471
12IGF1R_20145208_ChIP-Seq_DFB_Human2.26677496
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19616049
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19385178
15ELK1_19687146_ChIP-ChIP_HELA_Human2.17685075
16EWS_26573619_Chip-Seq_HEK293_Human2.12272243
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11706875
18TAF15_26573619_Chip-Seq_HEK293_Human2.04986673
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97932611
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96462171
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.95679785
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88855943
23FOXP3_21729870_ChIP-Seq_TREG_Human1.86778236
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.84131502
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83063896
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82085155
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81588103
28FUS_26573619_Chip-Seq_HEK293_Human1.79230316
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68006802
30MYC_18940864_ChIP-ChIP_HL60_Human1.63428692
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62221276
32P300_19829295_ChIP-Seq_ESCs_Human1.61498894
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58679507
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58593802
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57958248
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57139713
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55783402
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54563511
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.52733137
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.51581551
41TP53_22573176_ChIP-Seq_HFKS_Human1.48583734
42ER_23166858_ChIP-Seq_MCF-7_Human1.48330689
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47360421
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46525379
45SOX2_19829295_ChIP-Seq_ESCs_Human1.38891852
46NANOG_19829295_ChIP-Seq_ESCs_Human1.38891852
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38054490
48CBP_20019798_ChIP-Seq_JUKART_Human1.38054490
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36110702
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.34953674
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34312900
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33980917
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.33980917
54GBX2_23144817_ChIP-Seq_PC3_Human1.33582168
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31042279
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30719110
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29176570
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26139882
59AR_20517297_ChIP-Seq_VCAP_Human1.26034883
60GATA3_26560356_Chip-Seq_TH2_Human1.25250358
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.24903155
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23956319
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21707509
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20049455
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19803329
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17137556
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.15770453
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.14756221
69MYB_26560356_Chip-Seq_TH2_Human1.13990735
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13735520
71BCAT_22108803_ChIP-Seq_LS180_Human1.09672319
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.09601559
73HTT_18923047_ChIP-ChIP_STHdh_Human1.08641230
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08634989
75NCOR_22424771_ChIP-Seq_293T_Human1.05382221
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04328218
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02365750
78IRF1_19129219_ChIP-ChIP_H3396_Human1.02235850
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00079145
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99787109
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.99325692
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.99322025
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98175711
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97419991
85P53_22387025_ChIP-Seq_ESCs_Mouse0.96571991
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96561471
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96425819
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96372933
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96358410
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.95604564
91STAT3_18555785_Chip-Seq_ESCs_Mouse0.95567361
92TCF4_22108803_ChIP-Seq_LS180_Human0.95063341
93P300_18555785_Chip-Seq_ESCs_Mouse0.94930441
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94527499
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93949505
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93436830
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92863167
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91707957
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90781595
100AR_25329375_ChIP-Seq_VCAP_Human0.90489339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.61398555
2MP0001835_abnormal_antigen_presentation3.59493423
3MP0008877_abnormal_DNA_methylation2.79014813
4MP0006072_abnormal_retinal_apoptosis2.41963427
5MP0008872_abnormal_physiological_respon2.37161726
6MP0002837_dystrophic_cardiac_calcinosis2.24248699
7MP0002102_abnormal_ear_morphology2.23903925
8MP0006292_abnormal_olfactory_placode2.20617391
9MP0002876_abnormal_thyroid_physiology2.18534356
10MP0003786_premature_aging2.10783246
11MP0003195_calcinosis2.07504275
12MP0002736_abnormal_nociception_after2.00767456
13MP0001968_abnormal_touch/_nociception2.00592806
14MP0004147_increased_porphyrin_level1.93099430
15MP0005646_abnormal_pituitary_gland1.92779730
16MP0005551_abnormal_eye_electrophysiolog1.82955823
17MP0008875_abnormal_xenobiotic_pharmacok1.81110779
18MP0002148_abnormal_hypersensitivity_rea1.79373574
19MP0005084_abnormal_gallbladder_morpholo1.74561163
20MP0008058_abnormal_DNA_repair1.72757702
21MP0001873_stomach_inflammation1.68482834
22MP0009785_altered_susceptibility_to1.63465681
23MP0001800_abnormal_humoral_immune1.63115927
24MP0002163_abnormal_gland_morphology1.59178424
25MP0003718_maternal_effect1.55672041
26MP0000685_abnormal_immune_system1.50102248
27MP0005253_abnormal_eye_physiology1.48742374
28MP0000372_irregular_coat_pigmentation1.46664854
29MP0005075_abnormal_melanosome_morpholog1.46529469
30MP0006036_abnormal_mitochondrial_physio1.44602487
31MP0003763_abnormal_thymus_physiology1.44216242
32MP0010094_abnormal_chromosome_stability1.41903859
33MP0009697_abnormal_copulation1.41398578
34MP0002138_abnormal_hepatobiliary_system1.40962331
35MP0009333_abnormal_splenocyte_physiolog1.40732700
36MP0002166_altered_tumor_susceptibility1.39966057
37MP0008057_abnormal_DNA_replication1.39949238
38MP0004142_abnormal_muscle_tone1.35359186
39MP0005645_abnormal_hypothalamus_physiol1.34237622
40MP0004885_abnormal_endolymph1.31855204
41MP0001790_abnormal_immune_system1.31546897
42MP0005387_immune_system_phenotype1.31546897
43MP0005000_abnormal_immune_tolerance1.29256696
44MP0003646_muscle_fatigue1.28984401
45MP0001984_abnormal_olfaction1.27396723
46MP0001905_abnormal_dopamine_level1.26116657
47MP0002723_abnormal_immune_serum1.24331018
48MP0001188_hyperpigmentation1.20023184
49MP0002006_tumorigenesis1.18840207
50MP0003567_abnormal_fetal_cardiomyocyte1.18342952
51MP0004145_abnormal_muscle_electrophysio1.18236342
52MP0005379_endocrine/exocrine_gland_phen1.17325102
53MP0004043_abnormal_pH_regulation1.16836758
54MP0003787_abnormal_imprinting1.16521267
55MP0001501_abnormal_sleep_pattern1.15909029
56MP0002420_abnormal_adaptive_immunity1.13637450
57MP0006082_CNS_inflammation1.12763423
58MP0001764_abnormal_homeostasis1.12292914
59MP0001819_abnormal_immune_cell1.11450375
60MP0003252_abnormal_bile_duct1.11411212
61MP0008995_early_reproductive_senescence1.08205891
62MP0003866_abnormal_defecation1.07421331
63MP0001529_abnormal_vocalization1.07107943
64MP0003806_abnormal_nucleotide_metabolis1.07069402
65MP0006035_abnormal_mitochondrial_morpho1.06663545
66MP0003880_abnormal_central_pattern1.06185072
67MP0005389_reproductive_system_phenotype1.05627136
68MP0002398_abnormal_bone_marrow1.05201609
69MP0002452_abnormal_antigen_presenting1.04139463
70MP0003878_abnormal_ear_physiology1.01707174
71MP0005377_hearing/vestibular/ear_phenot1.01707174
72MP0009745_abnormal_behavioral_response1.01011437
73MP0000689_abnormal_spleen_morphology1.00876051
74MP0001986_abnormal_taste_sensitivity0.98746108
75MP0005410_abnormal_fertilization0.97662185
76MP0001919_abnormal_reproductive_system0.97395237
77MP0006276_abnormal_autonomic_nervous0.95819759
78MP0000716_abnormal_immune_system0.95233125
79MP0002272_abnormal_nervous_system0.93773469
80MP0005085_abnormal_gallbladder_physiolo0.93396581
81MP0002277_abnormal_respiratory_mucosa0.91735683
82MP0005636_abnormal_mineral_homeostasis0.89421726
83MP0002160_abnormal_reproductive_system0.84681812
84MP0002693_abnormal_pancreas_physiology0.84627570
85MP0009764_decreased_sensitivity_to0.83989707
86MP0001486_abnormal_startle_reflex0.81884834
87MP0008007_abnormal_cellular_replicative0.81490534
88MP0002234_abnormal_pharynx_morphology0.81423078
89MP0003011_delayed_dark_adaptation0.80150133
90MP0010386_abnormal_urinary_bladder0.78987097
91MP0005332_abnormal_amino_acid0.78703209
92MP0001119_abnormal_female_reproductive0.78501279
93MP0010155_abnormal_intestine_physiology0.77303823
94MP0002722_abnormal_immune_system0.77027376
95MP0001661_extended_life_span0.75895543
96MP0000703_abnormal_thymus_morphology0.75078026
97MP0002429_abnormal_blood_cell0.74551032
98MP0009379_abnormal_foot_pigmentation0.74345959
99MP0002735_abnormal_chemical_nociception0.74271886
100MP0005025_abnormal_response_to0.72760739

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.72633145
2Hypoproteinemia (HP:0003075)3.70956536
3Severe combined immunodeficiency (HP:0004430)3.63792023
4Mitochondrial inheritance (HP:0001427)3.62275113
5Increased CSF lactate (HP:0002490)3.50868084
6Thyroiditis (HP:0100646)3.49702015
7Abnormality of B cell number (HP:0010975)3.40359523
8Hepatocellular necrosis (HP:0001404)3.31551713
9IgG deficiency (HP:0004315)3.31069044
10Pancreatic cysts (HP:0001737)3.22359125
11Progressive macrocephaly (HP:0004481)3.21625037
12Acute encephalopathy (HP:0006846)3.17978875
13Abolished electroretinogram (ERG) (HP:0000550)3.16092071
14Abnormal mitochondria in muscle tissue (HP:0008316)3.15716104
153-Methylglutaconic aciduria (HP:0003535)3.14618314
16Abnormality of T cell number (HP:0011839)3.13951125
17T lymphocytopenia (HP:0005403)3.13336294
18B lymphocytopenia (HP:0010976)3.07067706
19Molar tooth sign on MRI (HP:0002419)3.00950482
20Abnormality of midbrain morphology (HP:0002418)3.00950482
21Hepatic necrosis (HP:0002605)2.96620658
22Aplastic anemia (HP:0001915)2.94542552
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87991227
24Increased hepatocellular lipid droplets (HP:0006565)2.87966142
25Methylmalonic acidemia (HP:0002912)2.87829693
26Pancreatic fibrosis (HP:0100732)2.84548449
27Combined immunodeficiency (HP:0005387)2.82164469
28Lipid accumulation in hepatocytes (HP:0006561)2.77251900
29Nephronophthisis (HP:0000090)2.75473423
30Elevated erythrocyte sedimentation rate (HP:0003565)2.74886794
31True hermaphroditism (HP:0010459)2.73620600
32Congenital stationary night blindness (HP:0007642)2.67343071
33Increased serum lactate (HP:0002151)2.61830056
34Abnormal rod and cone electroretinograms (HP:0008323)2.60398580
35Stomatitis (HP:0010280)2.58433517
36Optic disc pallor (HP:0000543)2.56650304
37Cerebral edema (HP:0002181)2.53323446
38Decreased central vision (HP:0007663)2.51367164
39Constricted visual fields (HP:0001133)2.49821532
40Attenuation of retinal blood vessels (HP:0007843)2.43458944
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.42827748
42Abnormality of eosinophils (HP:0001879)2.42759989
43Congenital, generalized hypertrichosis (HP:0004540)2.42690425
44Panhypogammaglobulinemia (HP:0003139)2.37426944
45Abnormality of the prostate (HP:0008775)2.33528656
46Methylmalonic aciduria (HP:0012120)2.29218769
47Abnormality of T cells (HP:0002843)2.27211167
48Abnormality of the renal medulla (HP:0100957)2.26332179
49Abnormality of the renal cortex (HP:0011035)2.24795751
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.22523632
51Absent/shortened dynein arms (HP:0200106)2.22523632
52Hypothermia (HP:0002045)2.21749696
53Abnormality of alanine metabolism (HP:0010916)2.20545557
54Hyperalaninemia (HP:0003348)2.20545557
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20545557
56Renal Fanconi syndrome (HP:0001994)2.20243252
57Lactic acidosis (HP:0003128)2.20117431
58Eosinophilia (HP:0001880)2.18160299
59Renal cortical cysts (HP:0000803)2.17418833
60Autoimmune hemolytic anemia (HP:0001890)2.14033916
61Abnormality of macular pigmentation (HP:0008002)2.09582485
62Exertional dyspnea (HP:0002875)2.08007301
63Medial flaring of the eyebrow (HP:0010747)2.07053718
64Lethargy (HP:0001254)2.01790647
65Pancytopenia (HP:0001876)2.00828471
66Abnormality of the labia minora (HP:0012880)1.99879662
67Respiratory failure (HP:0002878)1.93340355
68Pendular nystagmus (HP:0012043)1.92245598
69Hypoplasia of the thymus (HP:0000778)1.89027726
70Increased intramyocellular lipid droplets (HP:0012240)1.87065237
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86732814
72Erythroderma (HP:0001019)1.85660912
73Decreased circulating renin level (HP:0003351)1.85638596
74Type I transferrin isoform profile (HP:0003642)1.85183089
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83334168
76Abnormality of the pons (HP:0007361)1.83074075
77CNS demyelination (HP:0007305)1.81644726
78Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81359791
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81359791
80Abnormality of vitamin B metabolism (HP:0004340)1.80800851
81Abnormality of the vitamin B12 metabolism (HP:0004341)1.78159116
82Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75859419
83Polydipsia (HP:0001959)1.74687884
84Abnormal drinking behavior (HP:0030082)1.74687884
85Abnormal biliary tract physiology (HP:0012439)1.74169457
86Bile duct proliferation (HP:0001408)1.74169457
87Leukodystrophy (HP:0002415)1.72824772
88Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72170470
89Abnormality of the anterior horn cell (HP:0006802)1.70628495
90Degeneration of anterior horn cells (HP:0002398)1.70628495
91Hypoplasia of the pons (HP:0012110)1.68474687
92Sclerocornea (HP:0000647)1.67008613
93Chronic diarrhea (HP:0002028)1.66955364
94Cystic liver disease (HP:0006706)1.66197322
95Glycosuria (HP:0003076)1.65238521
96Abnormality of urine glucose concentration (HP:0011016)1.65238521
97Supernumerary spleens (HP:0009799)1.64674416
98Abnormal protein N-linked glycosylation (HP:0012347)1.64326739
99Abnormal protein glycosylation (HP:0012346)1.64326739
100Abnormal glycosylation (HP:0012345)1.64326739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.42335558
2EIF2AK33.17362609
3ZAK3.09064531
4FRK2.91647087
5VRK22.49204794
6ADRBK22.45664603
7NUAK12.44000805
8MAP4K22.41967797
9MAP3K122.10024788
10WNK32.05955570
11VRK11.98158890
12BMPR1B1.95025158
13MST41.94518511
14TLK11.89725793
15PINK11.86107832
16TRIM281.83835761
17GRK11.80909301
18KDR1.77362714
19BMPR21.65924677
20MKNK21.65702179
21TAOK31.63061879
22BCKDK1.56833639
23NEK11.56317444
24WNK41.54664076
25BUB11.46197010
26PLK31.43252427
27TEC1.35717567
28NME11.31765882
29STK161.31602574
30MKNK11.28878688
31EIF2AK11.25025544
32ITK1.22834254
33SCYL21.18036321
34DAPK11.13982623
35PLK41.13580343
36ERBB31.09434867
37DAPK21.08411234
38PLK21.06528938
39CDC71.06219122
40MAP4K11.04425535
41PBK1.04183192
42TSSK61.04009959
43OXSR11.03646390
44SRPK11.03267851
45FES1.02632149
46EIF2AK20.97326311
47MAPK130.93260567
48ACVR1B0.84412919
49STK390.82059660
50INSRR0.80909979
51TAF10.80468967
52CDK190.80135827
53BCR0.80060530
54KIT0.78888854
55SYK0.77298027
56MYLK0.77208860
57TIE10.72973612
58MAP3K40.72956058
59PRKCE0.72557943
60PRKCQ0.71125927
61DYRK20.70958462
62IKBKB0.69570069
63TNIK0.69514445
64CSNK1G10.64562378
65CSNK1G30.63155988
66RPS6KA50.62724586
67PIK3CG0.62554210
68LCK0.61021591
69FLT30.60531791
70CSNK1G20.58072377
71TGFBR10.57879889
72PLK10.56150966
73MAPKAPK50.55333314
74MAP2K70.53259139
75CCNB10.51702068
76LYN0.50600212
77PASK0.49847808
78ATR0.48292266
79CSNK1A1L0.48098069
80BTK0.47937782
81MAPKAPK30.46932629
82PHKG10.46760501
83PHKG20.46760501
84MUSK0.46190681
85RPS6KA40.44932331
86ADRBK10.44047548
87CSF1R0.43963385
88TRPM70.43096734
89GRK70.41185242
90AURKB0.40277812
91MAP2K60.40047935
92CDK80.39936531
93TNK20.38176111
94IGF1R0.38035516
95CAMK2A0.37216203
96ILK0.35324708
97PRKCA0.34703178
98CSNK2A20.34078858
99OBSCN0.33990380
100CSNK2A10.33975584

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.40452529
2Protein export_Homo sapiens_hsa030603.23260269
3Oxidative phosphorylation_Homo sapiens_hsa001902.92098703
4Asthma_Homo sapiens_hsa053102.88998885
5Allograft rejection_Homo sapiens_hsa053302.74405845
6Primary immunodeficiency_Homo sapiens_hsa053402.66819837
7Autoimmune thyroid disease_Homo sapiens_hsa053202.64289046
8Graft-versus-host disease_Homo sapiens_hsa053322.51886697
9Parkinsons disease_Homo sapiens_hsa050122.42776636
10Type I diabetes mellitus_Homo sapiens_hsa049402.30113786
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.28881899
12RNA polymerase_Homo sapiens_hsa030202.19733995
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07210265
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86973212
15Antigen processing and presentation_Homo sapiens_hsa046121.77785040
16Homologous recombination_Homo sapiens_hsa034401.72789767
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58163378
18RNA degradation_Homo sapiens_hsa030181.56572104
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55522842
20Alzheimers disease_Homo sapiens_hsa050101.53224613
21Basal transcription factors_Homo sapiens_hsa030221.49426749
22Phototransduction_Homo sapiens_hsa047441.49119571
23Huntingtons disease_Homo sapiens_hsa050161.47123091
24Propanoate metabolism_Homo sapiens_hsa006401.46958318
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44024300
26Ribosome_Homo sapiens_hsa030101.40616110
27Rheumatoid arthritis_Homo sapiens_hsa053231.40492115
28Non-homologous end-joining_Homo sapiens_hsa034501.39809547
29Mismatch repair_Homo sapiens_hsa034301.36046004
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33023580
31Linoleic acid metabolism_Homo sapiens_hsa005911.30243462
32Fanconi anemia pathway_Homo sapiens_hsa034601.28952784
33One carbon pool by folate_Homo sapiens_hsa006701.18089446
34RNA transport_Homo sapiens_hsa030131.17646418
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15463660
36DNA replication_Homo sapiens_hsa030301.15297959
37Caffeine metabolism_Homo sapiens_hsa002321.13943717
38Nitrogen metabolism_Homo sapiens_hsa009101.10364187
39Hematopoietic cell lineage_Homo sapiens_hsa046401.10199301
40Butanoate metabolism_Homo sapiens_hsa006501.07899996
41Nucleotide excision repair_Homo sapiens_hsa034201.06442085
42Tryptophan metabolism_Homo sapiens_hsa003801.06317534
43Selenocompound metabolism_Homo sapiens_hsa004501.04784959
44Pyrimidine metabolism_Homo sapiens_hsa002401.02527509
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01705964
46Spliceosome_Homo sapiens_hsa030401.00915560
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97231835
48Peroxisome_Homo sapiens_hsa041460.94681389
49Purine metabolism_Homo sapiens_hsa002300.94536087
50Cardiac muscle contraction_Homo sapiens_hsa042600.93963007
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93082124
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91427381
53Olfactory transduction_Homo sapiens_hsa047400.89094421
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.84882996
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84187827
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79385185
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79008077
58Base excision repair_Homo sapiens_hsa034100.78763115
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.78418592
60Ether lipid metabolism_Homo sapiens_hsa005650.77181118
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76387750
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75203186
63Regulation of autophagy_Homo sapiens_hsa041400.71384391
64Chemical carcinogenesis_Homo sapiens_hsa052040.67844440
65Systemic lupus erythematosus_Homo sapiens_hsa053220.67436184
66Viral myocarditis_Homo sapiens_hsa054160.67323641
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67282057
68Sulfur metabolism_Homo sapiens_hsa009200.66585507
69Arachidonic acid metabolism_Homo sapiens_hsa005900.65837797
70Retinol metabolism_Homo sapiens_hsa008300.61231281
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59250739
72Taste transduction_Homo sapiens_hsa047420.56429331
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53387091
74Metabolic pathways_Homo sapiens_hsa011000.52104162
75T cell receptor signaling pathway_Homo sapiens_hsa046600.51246696
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.51176613
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51128444
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50624079
79Collecting duct acid secretion_Homo sapiens_hsa049660.50578004
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50576536
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.48792809
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.48529667
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47304345
84Nicotine addiction_Homo sapiens_hsa050330.46957042
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45639963
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45104845
87Glutathione metabolism_Homo sapiens_hsa004800.44594564
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.44403128
89Fatty acid elongation_Homo sapiens_hsa000620.38642344
90Staphylococcus aureus infection_Homo sapiens_hsa051500.36892113
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34515427
92Fat digestion and absorption_Homo sapiens_hsa049750.32473788
93Pyruvate metabolism_Homo sapiens_hsa006200.31069031
94beta-Alanine metabolism_Homo sapiens_hsa004100.31020782
95Fatty acid degradation_Homo sapiens_hsa000710.29346145
96Epstein-Barr virus infection_Homo sapiens_hsa051690.28645087
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26577843
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26348485
99Measles_Homo sapiens_hsa051620.25776557
100Salivary secretion_Homo sapiens_hsa049700.25153406

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