NPM1P34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.00474895
2proteasome assembly (GO:0043248)5.32685994
3cytidine metabolic process (GO:0046087)4.83274168
4cytidine catabolic process (GO:0006216)4.83274168
5cytidine deamination (GO:0009972)4.83274168
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.76980559
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.33576652
8regulation of cellular amino acid metabolic process (GO:0006521)4.07733131
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.03090672
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.01292842
11ATP synthesis coupled proton transport (GO:0015986)4.01292842
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.98354551
13rRNA modification (GO:0000154)3.93221103
14platelet dense granule organization (GO:0060155)3.82113356
15protein neddylation (GO:0045116)3.81813595
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79168558
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.77700560
18signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.69185325
19signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.69185325
20signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.69185325
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.67236000
22intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.67236000
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.54451278
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.53107287
25cullin deneddylation (GO:0010388)3.48136653
26signal transduction involved in DNA integrity checkpoint (GO:0072401)3.47142060
27signal transduction involved in DNA damage checkpoint (GO:0072422)3.47142060
28respiratory chain complex IV assembly (GO:0008535)3.46180469
29protein deneddylation (GO:0000338)3.44098013
30water-soluble vitamin biosynthetic process (GO:0042364)3.43971342
31signal transduction involved in cell cycle checkpoint (GO:0072395)3.42973186
32respiratory electron transport chain (GO:0022904)3.42012052
33electron transport chain (GO:0022900)3.38852543
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38803472
35protein complex biogenesis (GO:0070271)3.37897269
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37895194
37negative regulation of ligase activity (GO:0051352)3.37724315
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37724315
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33289557
40rRNA methylation (GO:0031167)3.28019352
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22068575
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.19214584
43mitochondrial respiratory chain complex assembly (GO:0033108)3.14334498
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.13171099
45NADH dehydrogenase complex assembly (GO:0010257)3.13171099
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13171099
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11775534
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11775534
49chaperone-mediated protein transport (GO:0072321)3.10970944
50antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.06617371
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04667034
52cytochrome complex assembly (GO:0017004)3.02381901
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01533489
54DNA demethylation (GO:0080111)2.98977621
55regulation of chronic inflammatory response (GO:0002676)2.94546015
56pseudouridine synthesis (GO:0001522)2.94107747
57positive regulation of ligase activity (GO:0051351)2.91048086
58DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.89778519
59positive regulation of protein homodimerization activity (GO:0090073)2.89210792
60regulation of cellular amine metabolic process (GO:0033238)2.89006131
61L-methionine salvage (GO:0071267)2.86672715
62L-methionine biosynthetic process (GO:0071265)2.86672715
63amino acid salvage (GO:0043102)2.86672715
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85493538
65positive regulation of cell cycle arrest (GO:0071158)2.84260078
66termination of RNA polymerase III transcription (GO:0006386)2.80185827
67transcription elongation from RNA polymerase III promoter (GO:0006385)2.80185827
68iron-sulfur cluster assembly (GO:0016226)2.78944962
69metallo-sulfur cluster assembly (GO:0031163)2.78944962
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75127247
71ribosomal small subunit assembly (GO:0000028)2.73817500
72GPI anchor biosynthetic process (GO:0006506)2.71371309
73regulation of regulatory T cell differentiation (GO:0045589)2.70216856
74ribosome assembly (GO:0042255)2.68079514
75positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.67239858
76S-adenosylmethionine metabolic process (GO:0046500)2.66437884
77Arp2/3 complex-mediated actin nucleation (GO:0034314)2.65641342
78response to pheromone (GO:0019236)2.64655714
79kynurenine metabolic process (GO:0070189)2.64259047
80positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.64205376
81negative regulation by host of viral transcription (GO:0043922)2.63723335
82somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.63335153
83isotype switching (GO:0045190)2.63335153
84somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.63335153
85negative regulation of T cell apoptotic process (GO:0070233)2.63212934
86antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.62809980
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.61914733
88GPI anchor metabolic process (GO:0006505)2.60607707
89DNA dealkylation (GO:0035510)2.59564475
90negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.58101129
91tryptophan catabolic process (GO:0006569)2.57674675
92indole-containing compound catabolic process (GO:0042436)2.57674675
93indolalkylamine catabolic process (GO:0046218)2.57674675
94negative regulation of calcium ion transport into cytosol (GO:0010523)2.56163610
95positive regulation of alpha-beta T cell proliferation (GO:0046641)2.53605917
96positive regulation of defense response to virus by host (GO:0002230)2.52056342
97maturation of 5.8S rRNA (GO:0000460)2.52055623
98regulation of ubiquitin-protein transferase activity (GO:0051438)2.51354254
99aldehyde catabolic process (GO:0046185)2.49044759
100deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.45993602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.32627988
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.06045048
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.32740224
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.06693300
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.03331953
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99331633
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93222695
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93188475
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88491554
10VDR_23849224_ChIP-Seq_CD4+_Human2.85922720
11VDR_22108803_ChIP-Seq_LS180_Human2.74634040
12ZNF274_21170338_ChIP-Seq_K562_Hela2.55923257
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.44140561
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.41437182
15ELK1_19687146_ChIP-ChIP_HELA_Human2.32687603
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.32501926
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14080646
18IGF1R_20145208_ChIP-Seq_DFB_Human2.13594805
19FOXP3_21729870_ChIP-Seq_TREG_Human2.12784838
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08268052
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02128353
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.01322152
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93189382
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91358126
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90727048
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88119185
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83054898
28EWS_26573619_Chip-Seq_HEK293_Human1.76223533
29MYC_18940864_ChIP-ChIP_HL60_Human1.68950083
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.61672152
31TAF15_26573619_Chip-Seq_HEK293_Human1.57464745
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56738325
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53550572
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.50612403
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.50213990
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49976273
37MYB_26560356_Chip-Seq_TH2_Human1.48382410
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48058745
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47462320
40TP53_22573176_ChIP-Seq_HFKS_Human1.47150267
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46304390
42FUS_26573619_Chip-Seq_HEK293_Human1.43635991
43GATA3_26560356_Chip-Seq_TH2_Human1.37856702
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36061552
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.36061552
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35120677
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35043699
48AR_20517297_ChIP-Seq_VCAP_Human1.31016131
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30023562
50ER_23166858_ChIP-Seq_MCF-7_Human1.28833882
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28564489
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.27183123
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26318461
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26287111
55P300_19829295_ChIP-Seq_ESCs_Human1.25599034
56SOX2_19829295_ChIP-Seq_ESCs_Human1.25578560
57NANOG_19829295_ChIP-Seq_ESCs_Human1.25578560
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24384316
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24033870
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23556609
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23519488
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21547351
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21027950
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19939093
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18933258
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18594443
67DCP1A_22483619_ChIP-Seq_HELA_Human1.18001069
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14128227
69GABP_19822575_ChIP-Seq_HepG2_Human1.14066135
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13766464
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.13710097
72CBP_20019798_ChIP-Seq_JUKART_Human1.13374101
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13374101
74NCOR_22424771_ChIP-Seq_293T_Human1.12811855
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12358481
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10272482
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08996851
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07980607
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07627025
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07513861
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07128628
82IRF1_19129219_ChIP-ChIP_H3396_Human1.06400993
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05873289
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05086648
85ERG_20517297_ChIP-Seq_VCAP_Human1.04931709
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.04321548
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03358531
88GATA3_27048872_Chip-Seq_THYMUS_Human1.03126349
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03111690
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.01569111
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01222008
92HTT_18923047_ChIP-ChIP_STHdh_Human1.00251832
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.00047032
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99415205
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99116750
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98286018
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96330977
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95510807
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.93591427
100NANOG_20526341_ChIP-Seq_ESCs_Human0.92280086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.73526231
2MP0001835_abnormal_antigen_presentation3.06240892
3MP0002102_abnormal_ear_morphology2.45359285
4MP0009785_altered_susceptibility_to2.24230511
5MP0005646_abnormal_pituitary_gland2.16680382
6MP0004147_increased_porphyrin_level2.13872032
7MP0008877_abnormal_DNA_methylation2.11518865
8MP0002837_dystrophic_cardiac_calcinosis2.09434845
9MP0008058_abnormal_DNA_repair2.08578581
10MP0006072_abnormal_retinal_apoptosis2.08322054
11MP0000372_irregular_coat_pigmentation2.05320214
12MP0005075_abnormal_melanosome_morpholog2.02822350
13MP0001873_stomach_inflammation2.01144819
14MP0009333_abnormal_splenocyte_physiolog1.98682940
15MP0008872_abnormal_physiological_respon1.95963689
16MP0002166_altered_tumor_susceptibility1.94426400
17MP0008875_abnormal_xenobiotic_pharmacok1.91993188
18MP0009697_abnormal_copulation1.90324548
19MP0002148_abnormal_hypersensitivity_rea1.88213700
20MP0001764_abnormal_homeostasis1.87014182
21MP0005084_abnormal_gallbladder_morpholo1.85761481
22MP0003786_premature_aging1.81922892
23MP0006036_abnormal_mitochondrial_physio1.80571218
24MP0001800_abnormal_humoral_immune1.76230271
25MP0002006_tumorigenesis1.70883437
26MP0003763_abnormal_thymus_physiology1.69317848
27MP0002876_abnormal_thyroid_physiology1.64047689
28MP0005000_abnormal_immune_tolerance1.62473755
29MP0003195_calcinosis1.59653739
30MP0005551_abnormal_eye_electrophysiolog1.56675563
31MP0005645_abnormal_hypothalamus_physiol1.53247514
32MP0001968_abnormal_touch/_nociception1.51482449
33MP0006292_abnormal_olfactory_placode1.48628490
34MP0003806_abnormal_nucleotide_metabolis1.47795721
35MP0002138_abnormal_hepatobiliary_system1.45138311
36MP0003646_muscle_fatigue1.44192931
37MP0000685_abnormal_immune_system1.44121743
38MP0003718_maternal_effect1.43865959
39MP0006082_CNS_inflammation1.40709390
40MP0005085_abnormal_gallbladder_physiolo1.40372295
41MP0002723_abnormal_immune_serum1.38873299
42MP0005253_abnormal_eye_physiology1.36493851
43MP0002420_abnormal_adaptive_immunity1.33352128
44MP0002163_abnormal_gland_morphology1.32992044
45MP0002736_abnormal_nociception_after1.32212688
46MP0010386_abnormal_urinary_bladder1.30425176
47MP0001819_abnormal_immune_cell1.30371043
48MP0005389_reproductive_system_phenotype1.29499798
49MP0002452_abnormal_antigen_presenting1.25655024
50MP0001905_abnormal_dopamine_level1.23342385
51MP0003252_abnormal_bile_duct1.23091883
52MP0005379_endocrine/exocrine_gland_phen1.21821097
53MP0001501_abnormal_sleep_pattern1.21313639
54MP0002398_abnormal_bone_marrow1.20236116
55MP0005387_immune_system_phenotype1.18807206
56MP0001790_abnormal_immune_system1.18807206
57MP0003866_abnormal_defecation1.18688053
58MP0005025_abnormal_response_to1.16769719
59MP0010094_abnormal_chromosome_stability1.15776954
60MP0009764_decreased_sensitivity_to1.15612359
61MP0002160_abnormal_reproductive_system1.15053111
62MP0004145_abnormal_muscle_electrophysio1.13149535
63MP0001188_hyperpigmentation1.13101418
64MP0002693_abnormal_pancreas_physiology1.09795900
65MP0000689_abnormal_spleen_morphology1.09555206
66MP0000716_abnormal_immune_system1.08356816
67MP0003186_abnormal_redox_activity0.99921410
68MP0008057_abnormal_DNA_replication0.99506017
69MP0001661_extended_life_span0.96867327
70MP0010155_abnormal_intestine_physiology0.94702647
71MP0001986_abnormal_taste_sensitivity0.94666717
72MP0002277_abnormal_respiratory_mucosa0.93737171
73MP0002405_respiratory_system_inflammati0.93714768
74MP0001919_abnormal_reproductive_system0.93504630
75MP0002722_abnormal_immune_system0.92616359
76MP0005636_abnormal_mineral_homeostasis0.91637470
77MP0008995_early_reproductive_senescence0.91580168
78MP0004885_abnormal_endolymph0.91154027
79MP0001845_abnormal_inflammatory_respons0.91095615
80MP0006276_abnormal_autonomic_nervous0.90500039
81MP0001529_abnormal_vocalization0.90055638
82MP0006035_abnormal_mitochondrial_morpho0.89184875
83MP0003567_abnormal_fetal_cardiomyocyte0.88122264
84MP0002429_abnormal_blood_cell0.86865078
85MP0000703_abnormal_thymus_morphology0.85898272
86MP0002132_abnormal_respiratory_system0.85140231
87MP0000465_gastrointestinal_hemorrhage0.81711089
88MP0008469_abnormal_protein_level0.81643243
89MP0001119_abnormal_female_reproductive0.80701341
90MP0003724_increased_susceptibility_to0.80479143
91MP0005174_abnormal_tail_pigmentation0.80465055
92MP0004957_abnormal_blastocyst_morpholog0.79625528
93MP0002095_abnormal_skin_pigmentation0.79478782
94MP0003011_delayed_dark_adaptation0.78871137
95MP0003045_fibrosis0.78219543
96MP0004043_abnormal_pH_regulation0.75300723
97MP0005332_abnormal_amino_acid0.73955914
98MP0005410_abnormal_fertilization0.73687589
99MP0003137_abnormal_impulse_conducting0.72687717
100MP0004142_abnormal_muscle_tone0.72132274

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.19627034
2Aplastic anemia (HP:0001915)4.10412101
3Acute necrotizing encephalopathy (HP:0006965)4.09150261
4Increased CSF lactate (HP:0002490)4.05260164
5Hepatocellular necrosis (HP:0001404)4.03790303
6Abnormal mitochondria in muscle tissue (HP:0008316)3.68677198
7Hepatic necrosis (HP:0002605)3.65460274
8Acute encephalopathy (HP:0006846)3.60556167
9Progressive macrocephaly (HP:0004481)3.44602378
10IgG deficiency (HP:0004315)3.28713384
11Increased hepatocellular lipid droplets (HP:0006565)3.28037621
12Lipid accumulation in hepatocytes (HP:0006561)3.08128295
13Abnormality of B cell number (HP:0010975)3.01021091
14Severe combined immunodeficiency (HP:0004430)2.96253456
15Cerebral edema (HP:0002181)2.92314857
16Congenital stationary night blindness (HP:0007642)2.91349998
17Hypoproteinemia (HP:0003075)2.90510274
18Abnormality of T cell number (HP:0011839)2.89101250
193-Methylglutaconic aciduria (HP:0003535)2.88888184
20Elevated erythrocyte sedimentation rate (HP:0003565)2.87413586
21Increased serum lactate (HP:0002151)2.86333855
22Pancreatic cysts (HP:0001737)2.86202062
23Abolished electroretinogram (ERG) (HP:0000550)2.82255217
24T lymphocytopenia (HP:0005403)2.79148697
25Autoimmune hemolytic anemia (HP:0001890)2.74240320
26Congenital, generalized hypertrichosis (HP:0004540)2.74160445
27Methylmalonic acidemia (HP:0002912)2.70319147
28Abnormality of the prostate (HP:0008775)2.67486767
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67096254
30Abnormality of alanine metabolism (HP:0010916)2.67096254
31Hyperalaninemia (HP:0003348)2.67096254
32Reduced antithrombin III activity (HP:0001976)2.66760944
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65713392
34Lactic acidosis (HP:0003128)2.64362369
35B lymphocytopenia (HP:0010976)2.62078965
36Type I transferrin isoform profile (HP:0003642)2.61455368
37Thyroiditis (HP:0100646)2.60727323
38Decreased central vision (HP:0007663)2.54499417
39Methylmalonic aciduria (HP:0012120)2.52031664
40Abnormal rod and cone electroretinograms (HP:0008323)2.49556736
41Molar tooth sign on MRI (HP:0002419)2.46186009
42Abnormality of midbrain morphology (HP:0002418)2.46186009
43Increased intramyocellular lipid droplets (HP:0012240)2.45809476
44Stomatitis (HP:0010280)2.45574993
45Renal Fanconi syndrome (HP:0001994)2.45443807
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44907140
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44907140
48Optic disc pallor (HP:0000543)2.44443643
49Attenuation of retinal blood vessels (HP:0007843)2.41432703
50Abnormality of T cells (HP:0002843)2.40830448
51Hypothermia (HP:0002045)2.40225372
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38293459
53Abnormal protein N-linked glycosylation (HP:0012347)2.38293459
54Abnormal protein glycosylation (HP:0012346)2.38293459
55Abnormal glycosylation (HP:0012345)2.38293459
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37681821
57Constricted visual fields (HP:0001133)2.34565144
58Respiratory failure (HP:0002878)2.32841191
59Lethargy (HP:0001254)2.32742906
60True hermaphroditism (HP:0010459)2.31660047
61Abnormality of macular pigmentation (HP:0008002)2.30613770
62Pancytopenia (HP:0001876)2.30118561
63Medial flaring of the eyebrow (HP:0010747)2.25780036
64Exertional dyspnea (HP:0002875)2.22449006
65CNS demyelination (HP:0007305)2.21555243
66Increased IgM level (HP:0003496)2.21352927
67Oral leukoplakia (HP:0002745)2.19197467
68Pancreatic fibrosis (HP:0100732)2.18833563
69Combined immunodeficiency (HP:0005387)2.16547350
70Nephronophthisis (HP:0000090)2.15931459
71Abnormality of eosinophils (HP:0001879)2.04395576
72Hyperglycinemia (HP:0002154)2.01775563
73Increased muscle lipid content (HP:0009058)2.01449783
74Ketoacidosis (HP:0001993)2.00121382
75Autoimmune thrombocytopenia (HP:0001973)1.98135660
76Type 2 muscle fiber atrophy (HP:0003554)1.97797448
77Ketosis (HP:0001946)1.97382607
78Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94301268
79Dicarboxylic aciduria (HP:0003215)1.94301268
80Colon cancer (HP:0003003)1.92818363
81Abnormality of T cell physiology (HP:0011840)1.91330800
82Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.90689549
83Abnormality of serum amino acid levels (HP:0003112)1.89726029
84Generalized aminoaciduria (HP:0002909)1.88941692
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87037344
86Renal cortical cysts (HP:0000803)1.86240804
87Abnormality of the renal cortex (HP:0011035)1.85868982
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85512956
89Leukodystrophy (HP:0002415)1.83219001
90Chronic sinusitis (HP:0011109)1.82442068
91IgM deficiency (HP:0002850)1.80744935
92Exercise intolerance (HP:0003546)1.79110838
93Abnormality of serine family amino acid metabolism (HP:0010894)1.77794118
94Abnormality of glycine metabolism (HP:0010895)1.77794118
95Metaphyseal dysplasia (HP:0100255)1.75439118
96Abnormality of the phalanges of the 5th finger (HP:0004213)1.74353735
97Abnormality of the renal medulla (HP:0100957)1.73687053
98Congenital primary aphakia (HP:0007707)1.72451823
99Hyperglycinuria (HP:0003108)1.72257441
100Glycosuria (HP:0003076)1.72084945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.98350621
2VRK22.92632476
3EIF2AK32.80649742
4TAOK32.79550142
5KDR2.61737260
6ZAK2.56466489
7MAP4K22.49707159
8FRK2.32278220
9ADRBK22.30546688
10MST42.28660138
11BCKDK2.26863475
12TLK12.24915354
13NUAK12.09937835
14VRK11.97222316
15STK161.80398007
16GRK11.80081829
17BUB11.62070907
18PINK11.60409119
19DAPK11.53265456
20BMPR21.53175542
21DAPK21.48411653
22ITK1.42920174
23CDK191.42256765
24ERBB31.41715767
25CSNK1G11.35900779
26SCYL21.30672671
27TEC1.26391034
28TSSK61.20363986
29MAP3K121.19663646
30CSNK1G31.17827139
31TESK21.16587450
32PLK31.15847232
33OXSR11.14491596
34TRIM281.13296371
35MAPKAPK31.11793684
36MAP4K11.10770460
37EIF2AK11.09352952
38BCR1.05924000
39INSRR1.04411577
40WNK41.00657819
41WNK31.00289664
42CSNK1G20.97477692
43NME10.96756875
44KIT0.95104497
45CSNK1A1L0.94999899
46SYK0.92313254
47SRPK10.92258588
48BMPR1B0.91751334
49TAF10.89543996
50PASK0.87995017
51MKNK10.87923162
52RPS6KA40.86587773
53EIF2AK20.86407309
54STK390.86163609
55PLK20.85977322
56NLK0.85117098
57TIE10.84001911
58PLK40.76581751
59IKBKB0.75992384
60MYLK0.71046643
61PRKCQ0.68466831
62TRPM70.68205512
63GRK60.66434008
64MKNK20.65888393
65LCK0.65736200
66CDC70.64613713
67FES0.62510866
68NEK10.61277672
69RIPK40.60852029
70RPS6KA50.60760367
71IKBKE0.58506365
72LIMK10.56017905
73CSF1R0.55979116
74PDK20.55924750
75FLT30.54333733
76PRKCE0.53942970
77LYN0.53431097
78GRK70.51560988
79PHKG10.51168220
80PHKG20.51168220
81DAPK30.50690010
82MAPKAPK50.49302942
83OBSCN0.48971695
84PLK10.48355020
85BTK0.48079175
86CCNB10.48043580
87ATR0.46928160
88STK38L0.45235349
89GRK50.45139327
90MAP3K40.44662613
91ACVR1B0.44613909
92MAPK130.43421015
93CSNK2A10.43390273
94PBK0.43211692
95MATK0.42205558
96MUSK0.41463755
97IGF1R0.41408129
98PIK3CG0.41283000
99CSNK1A10.38461794
100CSNK2A20.35709433

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.04572563
2Oxidative phosphorylation_Homo sapiens_hsa001903.14304974
3Asthma_Homo sapiens_hsa053102.88935981
4Primary immunodeficiency_Homo sapiens_hsa053402.81071290
5Protein export_Homo sapiens_hsa030602.75860055
6Autoimmune thyroid disease_Homo sapiens_hsa053202.63999902
7Allograft rejection_Homo sapiens_hsa053302.63913640
8Parkinsons disease_Homo sapiens_hsa050122.61702688
9Graft-versus-host disease_Homo sapiens_hsa053322.35971853
10Type I diabetes mellitus_Homo sapiens_hsa049402.27785461
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.16139844
12RNA polymerase_Homo sapiens_hsa030202.14854020
13Antigen processing and presentation_Homo sapiens_hsa046121.90754176
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85650312
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79719117
16Homologous recombination_Homo sapiens_hsa034401.76594184
17Ribosome_Homo sapiens_hsa030101.76101486
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71070022
19Huntingtons disease_Homo sapiens_hsa050161.66524228
20Alzheimers disease_Homo sapiens_hsa050101.62011645
21Propanoate metabolism_Homo sapiens_hsa006401.56121951
22RNA degradation_Homo sapiens_hsa030181.54445771
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53742312
24DNA replication_Homo sapiens_hsa030301.51457457
25Rheumatoid arthritis_Homo sapiens_hsa053231.43153065
26Mismatch repair_Homo sapiens_hsa034301.37389371
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35482122
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31015858
29Phototransduction_Homo sapiens_hsa047441.28153985
30Basal transcription factors_Homo sapiens_hsa030221.27748896
31Hematopoietic cell lineage_Homo sapiens_hsa046401.21123833
32Nucleotide excision repair_Homo sapiens_hsa034201.19047439
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18039854
34One carbon pool by folate_Homo sapiens_hsa006701.17850616
35RNA transport_Homo sapiens_hsa030131.16021498
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15040457
37Pyrimidine metabolism_Homo sapiens_hsa002401.10581929
38Linoleic acid metabolism_Homo sapiens_hsa005911.10191128
39Base excision repair_Homo sapiens_hsa034101.08502542
40Purine metabolism_Homo sapiens_hsa002301.02124964
41Non-homologous end-joining_Homo sapiens_hsa034501.00981840
42Butanoate metabolism_Homo sapiens_hsa006501.00169876
43Spliceosome_Homo sapiens_hsa030400.99963949
44Fanconi anemia pathway_Homo sapiens_hsa034600.96759582
45Caffeine metabolism_Homo sapiens_hsa002320.94558258
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.94482863
47Cardiac muscle contraction_Homo sapiens_hsa042600.93446491
48Peroxisome_Homo sapiens_hsa041460.91048573
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.89411279
50Nitrogen metabolism_Homo sapiens_hsa009100.88382137
51Tryptophan metabolism_Homo sapiens_hsa003800.84432466
52Viral myocarditis_Homo sapiens_hsa054160.83146033
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82316920
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81907700
55Selenocompound metabolism_Homo sapiens_hsa004500.81776428
56Sulfur metabolism_Homo sapiens_hsa009200.77736624
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73300996
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72802282
59Regulation of autophagy_Homo sapiens_hsa041400.71617585
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70106651
61Fatty acid elongation_Homo sapiens_hsa000620.68844484
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67313345
63Systemic lupus erythematosus_Homo sapiens_hsa053220.67067392
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66026180
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65579936
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.64718385
67Chemical carcinogenesis_Homo sapiens_hsa052040.64119868
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62410799
69Olfactory transduction_Homo sapiens_hsa047400.61784466
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.59720084
71Glutathione metabolism_Homo sapiens_hsa004800.59312174
72Arachidonic acid metabolism_Homo sapiens_hsa005900.58836902
73Metabolic pathways_Homo sapiens_hsa011000.58508121
74Ether lipid metabolism_Homo sapiens_hsa005650.57923512
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57663876
76Staphylococcus aureus infection_Homo sapiens_hsa051500.56189293
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53536280
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.52354165
79Retinol metabolism_Homo sapiens_hsa008300.52138189
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51320394
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50593248
82Collecting duct acid secretion_Homo sapiens_hsa049660.50169116
83T cell receptor signaling pathway_Homo sapiens_hsa046600.49765744
84Herpes simplex infection_Homo sapiens_hsa051680.46019974
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45890960
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.44838763
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44274736
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42570589
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42267913
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39462669
91beta-Alanine metabolism_Homo sapiens_hsa004100.38364408
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36394110
93Taste transduction_Homo sapiens_hsa047420.35398350
94Measles_Homo sapiens_hsa051620.35052152
95Pyruvate metabolism_Homo sapiens_hsa006200.32528450
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31706479
97Legionellosis_Homo sapiens_hsa051340.30719083
98Epstein-Barr virus infection_Homo sapiens_hsa051690.29954993
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27716882
100Folate biosynthesis_Homo sapiens_hsa007900.25453176

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