NPM1P35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.77420824
2rRNA modification (GO:0000154)4.34395168
3proteasome assembly (GO:0043248)4.29659132
4exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.88559582
5rRNA methylation (GO:0031167)3.87786159
6establishment of protein localization to mitochondrial membrane (GO:0090151)3.87203725
7positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.84714417
8nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.81206365
9chaperone-mediated protein transport (GO:0072321)3.79083634
10ribosome assembly (GO:0042255)3.64907990
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.63425938
12ATP synthesis coupled proton transport (GO:0015986)3.57759490
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.57759490
14regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.50228895
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42195475
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.42195475
17NADH dehydrogenase complex assembly (GO:0010257)3.42195475
18regulation of isotype switching to IgG isotypes (GO:0048302)3.38066030
19mitochondrial respiratory chain complex assembly (GO:0033108)3.34609113
20protein complex biogenesis (GO:0070271)3.34336210
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32719745
22cullin deneddylation (GO:0010388)3.32392757
23protein neddylation (GO:0045116)3.24746214
24somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.23844460
25somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.23844460
26isotype switching (GO:0045190)3.23844460
27protein deneddylation (GO:0000338)3.21799202
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18951097
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.16923857
30termination of RNA polymerase III transcription (GO:0006386)3.16923857
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16534200
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16534200
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16534200
34regulation of cellular amino acid metabolic process (GO:0006521)3.15155301
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14387004
36preassembly of GPI anchor in ER membrane (GO:0016254)3.14372275
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.13275991
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.08577863
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.08577863
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06876586
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06876586
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02620533
43signal transduction involved in DNA damage checkpoint (GO:0072422)2.98879278
44signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98879278
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98416241
46negative regulation of ligase activity (GO:0051352)2.98416241
47water-soluble vitamin biosynthetic process (GO:0042364)2.98258229
48protein-cofactor linkage (GO:0018065)2.95270038
49signal transduction involved in cell cycle checkpoint (GO:0072395)2.94513560
50histone mRNA metabolic process (GO:0008334)2.94371460
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89987883
52positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.89644486
53negative regulation of DNA-dependent DNA replication (GO:2000104)2.89027765
54pseudouridine synthesis (GO:0001522)2.87369464
55positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.84595947
56DNA catabolic process, exonucleolytic (GO:0000738)2.81209369
57maturation of 5.8S rRNA (GO:0000460)2.75551954
58DNA double-strand break processing (GO:0000729)2.72863635
59peptidyl-histidine modification (GO:0018202)2.71590191
60organelle disassembly (GO:1903008)2.70796106
61mitochondrial RNA metabolic process (GO:0000959)2.69204839
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68952672
63tRNA processing (GO:0008033)2.68927408
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67760384
65fucose catabolic process (GO:0019317)2.66617489
66L-fucose metabolic process (GO:0042354)2.66617489
67L-fucose catabolic process (GO:0042355)2.66617489
68piRNA metabolic process (GO:0034587)2.64811492
69protein localization to mitochondrion (GO:0070585)2.64583614
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.63241670
71L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59826292
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.59468646
73protein targeting to mitochondrion (GO:0006626)2.59299080
74positive regulation of DNA recombination (GO:0045911)2.58458329
75regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.58088860
76electron transport chain (GO:0022900)2.57421294
77respiratory electron transport chain (GO:0022904)2.57401513
78respiratory chain complex IV assembly (GO:0008535)2.56796661
79positive regulation of ligase activity (GO:0051351)2.56633909
80positive regulation of isotype switching (GO:0045830)2.56590527
81rRNA catabolic process (GO:0016075)2.55738353
82mannosylation (GO:0097502)2.54609991
83GTP biosynthetic process (GO:0006183)2.53869300
84ribosomal large subunit biogenesis (GO:0042273)2.51141397
85chromatin remodeling at centromere (GO:0031055)2.50038814
86positive regulation of immunoglobulin mediated immune response (GO:0002891)2.49980600
87positive regulation of B cell mediated immunity (GO:0002714)2.49980600
88recombinational repair (GO:0000725)2.48469856
89DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.48467812
90mast cell activation (GO:0045576)2.48388497
91positive regulation of defense response to virus by host (GO:0002230)2.47991130
92negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.47351976
93platelet dense granule organization (GO:0060155)2.46192912
94CENP-A containing nucleosome assembly (GO:0034080)2.45661901
95double-strand break repair via homologous recombination (GO:0000724)2.45189108
96positive regulation of cell cycle arrest (GO:0071158)2.45151537
97regulation of hypersensitivity (GO:0002883)2.45116271
98rRNA metabolic process (GO:0016072)2.44714199
99rRNA processing (GO:0006364)2.44346351
100tRNA metabolic process (GO:0006399)2.41973372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.33612582
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.00898449
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.57904471
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72995830
5VDR_23849224_ChIP-Seq_CD4+_Human2.62890481
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52289350
7ZNF274_21170338_ChIP-Seq_K562_Hela2.50836679
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.50735375
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47904549
10ELK1_19687146_ChIP-ChIP_HELA_Human2.44736174
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42798416
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42644174
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32279995
14VDR_22108803_ChIP-Seq_LS180_Human2.32138265
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31347164
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.18887584
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16843052
18FOXP3_21729870_ChIP-Seq_TREG_Human2.14954605
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08549031
20IGF1R_20145208_ChIP-Seq_DFB_Human2.07737123
21EWS_26573619_Chip-Seq_HEK293_Human1.96691654
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91373757
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88807987
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.86744451
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85412197
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.78638193
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78190662
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77359978
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.72620762
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68226418
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65322181
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64544837
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63655381
34FUS_26573619_Chip-Seq_HEK293_Human1.58711099
35TAF15_26573619_Chip-Seq_HEK293_Human1.57825005
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.57066767
37P300_19829295_ChIP-Seq_ESCs_Human1.56238250
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53737866
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52792924
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49184252
41MYC_18940864_ChIP-ChIP_HL60_Human1.47972461
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45569605
43ER_23166858_ChIP-Seq_MCF-7_Human1.44999025
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35623308
45GATA3_26560356_Chip-Seq_TH2_Human1.35586491
46TP53_22573176_ChIP-Seq_HFKS_Human1.34696334
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33694834
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33261585
49DCP1A_22483619_ChIP-Seq_HELA_Human1.32831772
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.32341389
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31181570
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.31181570
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.30041510
54SOX2_19829295_ChIP-Seq_ESCs_Human1.27383821
55NANOG_19829295_ChIP-Seq_ESCs_Human1.27383821
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25241957
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23301319
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23168697
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23061481
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22912180
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.21648499
62CBP_20019798_ChIP-Seq_JUKART_Human1.18922328
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18922328
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18905060
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18868717
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15983019
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15954838
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14987864
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14636961
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13147368
71GABP_19822575_ChIP-Seq_HepG2_Human1.11274199
72AR_20517297_ChIP-Seq_VCAP_Human1.10486924
73MYB_26560356_Chip-Seq_TH2_Human1.10139570
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08519981
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08411417
76E2F7_22180533_ChIP-Seq_HELA_Human1.08366391
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07574250
78TTF2_22483619_ChIP-Seq_HELA_Human1.06117112
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.06028229
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05396143
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04455782
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04138687
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.03449155
84IRF1_19129219_ChIP-ChIP_H3396_Human1.01550958
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01501298
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.00718357
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97085246
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96564156
89HOXB7_26014856_ChIP-Seq_BT474_Human0.96087667
90CDX2_22108803_ChIP-Seq_LS180_Human0.95859073
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95441289
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94152542
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93271346
94RBPJ_21746931_ChIP-Seq_IB4_Human0.90425698
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.90124295
96E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90114252
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90017446
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89523390
99GATA3_26560356_Chip-Seq_TH1_Human0.89123906
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.88981969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.88247947
2MP0001835_abnormal_antigen_presentation3.54299965
3MP0000569_abnormal_digit_pigmentation3.09160765
4MP0003787_abnormal_imprinting2.75731323
5MP0005671_abnormal_response_to2.53559371
6MP0002837_dystrophic_cardiac_calcinosis2.52356638
7MP0002102_abnormal_ear_morphology2.49701523
8MP0005075_abnormal_melanosome_morpholog2.46968761
9MP0000372_irregular_coat_pigmentation2.25265936
10MP0003195_calcinosis2.13449201
11MP0003646_muscle_fatigue2.12526560
12MP0008872_abnormal_physiological_respon2.11588030
13MP0003786_premature_aging2.10805641
14MP0008058_abnormal_DNA_repair2.10022465
15MP0000685_abnormal_immune_system2.03788543
16MP0008875_abnormal_xenobiotic_pharmacok2.01854360
17MP0006072_abnormal_retinal_apoptosis1.99191954
18MP0010094_abnormal_chromosome_stability1.98893411
19MP0008057_abnormal_DNA_replication1.87275046
20MP0001800_abnormal_humoral_immune1.85990647
21MP0006035_abnormal_mitochondrial_morpho1.81988282
22MP0002166_altered_tumor_susceptibility1.73539617
23MP0004147_increased_porphyrin_level1.71244500
24MP0002006_tumorigenesis1.66945553
25MP0006036_abnormal_mitochondrial_physio1.65850855
26MP0004957_abnormal_blastocyst_morpholog1.65405572
27MP0003693_abnormal_embryo_hatching1.65104604
28MP0003806_abnormal_nucleotide_metabolis1.60443208
29MP0002148_abnormal_hypersensitivity_rea1.56982772
30MP0008007_abnormal_cellular_replicative1.56567456
31MP0006292_abnormal_olfactory_placode1.55437708
32MP0003724_increased_susceptibility_to1.49827486
33MP0003186_abnormal_redox_activity1.42743862
34MP0009785_altered_susceptibility_to1.42497764
35MP0004381_abnormal_hair_follicle1.41140871
36MP0000427_abnormal_hair_cycle1.40705191
37MP0003718_maternal_effect1.38954540
38MP0005387_immune_system_phenotype1.35209622
39MP0001790_abnormal_immune_system1.35209622
40MP0009697_abnormal_copulation1.30844913
41MP0002723_abnormal_immune_serum1.30674891
42MP0002452_abnormal_antigen_presenting1.29562428
43MP0005646_abnormal_pituitary_gland1.28827767
44MP0001986_abnormal_taste_sensitivity1.24907605
45MP0003763_abnormal_thymus_physiology1.20447554
46MP0004142_abnormal_muscle_tone1.20136893
47MP0005000_abnormal_immune_tolerance1.19012418
48MP0002420_abnormal_adaptive_immunity1.18788553
49MP0009764_decreased_sensitivity_to1.18611673
50MP0005551_abnormal_eye_electrophysiolog1.18602968
51MP0004145_abnormal_muscle_electrophysio1.18167914
52MP0002736_abnormal_nociception_after1.15841486
53MP0005389_reproductive_system_phenotype1.15619309
54MP0001819_abnormal_immune_cell1.15307896
55MP0003878_abnormal_ear_physiology1.11438751
56MP0005377_hearing/vestibular/ear_phenot1.11438751
57MP0002277_abnormal_respiratory_mucosa1.09644730
58MP0005253_abnormal_eye_physiology1.09122400
59MP0002138_abnormal_hepatobiliary_system1.08843712
60MP0005084_abnormal_gallbladder_morpholo1.08790903
61MP0001968_abnormal_touch/_nociception1.07609216
62MP0000689_abnormal_spleen_morphology1.06023935
63MP0006082_CNS_inflammation1.05797116
64MP0002398_abnormal_bone_marrow1.05099857
65MP0002876_abnormal_thyroid_physiology1.04157790
66MP0002163_abnormal_gland_morphology1.03320747
67MP0005171_absent_coat_pigmentation1.01172456
68MP0005174_abnormal_tail_pigmentation1.01010404
69MP0002160_abnormal_reproductive_system0.99658292
70MP0001853_heart_inflammation0.98634338
71MP0000716_abnormal_immune_system0.97956951
72MP0003077_abnormal_cell_cycle0.95475857
73MP0005379_endocrine/exocrine_gland_phen0.95195058
74MP0009333_abnormal_splenocyte_physiolog0.95156152
75MP0002095_abnormal_skin_pigmentation0.91850335
76MP0001919_abnormal_reproductive_system0.90561857
77MP0002751_abnormal_autonomic_nervous0.90426916
78MP0003866_abnormal_defecation0.89108844
79MP0001984_abnormal_olfaction0.88565626
80MP0008995_early_reproductive_senescence0.88530734
81MP0001293_anophthalmia0.88247525
82MP0005310_abnormal_salivary_gland0.87975050
83MP0002722_abnormal_immune_system0.85075547
84MP0001845_abnormal_inflammatory_respons0.84393811
85MP0002429_abnormal_blood_cell0.83829244
86MP0003136_yellow_coat_color0.82690576
87MP0004215_abnormal_myocardial_fiber0.82368749
88MP0003121_genomic_imprinting0.82135005
89MP0006054_spinal_hemorrhage0.82026508
90MP0003567_abnormal_fetal_cardiomyocyte0.81252454
91MP0002653_abnormal_ependyma_morphology0.81185456
92MP0005410_abnormal_fertilization0.80844731
93MP0001119_abnormal_female_reproductive0.80486001
94MP0001764_abnormal_homeostasis0.78319335
95MP0002396_abnormal_hematopoietic_system0.78219859
96MP0001501_abnormal_sleep_pattern0.77729074
97MP0002019_abnormal_tumor_incidence0.76856651
98MP0005025_abnormal_response_to0.76442687
99MP0000703_abnormal_thymus_morphology0.75839510
100MP0005408_hypopigmentation0.75394029

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.82584630
2Stomatitis (HP:0010280)3.70828447
3Mitochondrial inheritance (HP:0001427)3.47839467
4Increased CSF lactate (HP:0002490)3.45803712
5IgG deficiency (HP:0004315)3.37804478
6Progressive macrocephaly (HP:0004481)3.37508514
7Acute encephalopathy (HP:0006846)3.36534054
8Abnormal mitochondria in muscle tissue (HP:0008316)3.22378955
9Pancreatic cysts (HP:0001737)3.13595899
10Lipid accumulation in hepatocytes (HP:0006561)3.11572775
11Abnormality of T cell number (HP:0011839)3.09419537
12Increased hepatocellular lipid droplets (HP:0006565)3.08441379
13Congenital stationary night blindness (HP:0007642)3.02781811
14Abnormality of B cell number (HP:0010975)3.02340794
15Hepatocellular necrosis (HP:0001404)2.96129596
16T lymphocytopenia (HP:0005403)2.92009119
17Colon cancer (HP:0003003)2.81383712
183-Methylglutaconic aciduria (HP:0003535)2.78830282
19Abnormality of T cells (HP:0002843)2.70254048
20Methylmalonic acidemia (HP:0002912)2.69289692
21Nephronophthisis (HP:0000090)2.66344047
22Elevated erythrocyte sedimentation rate (HP:0003565)2.65480682
23Hepatic necrosis (HP:0002605)2.63813857
24Cerebral edema (HP:0002181)2.60757551
25Thyroiditis (HP:0100646)2.59879151
26Hypoproteinemia (HP:0003075)2.59535633
27Exertional dyspnea (HP:0002875)2.55433753
28Increased serum lactate (HP:0002151)2.54374512
29Pancreatic fibrosis (HP:0100732)2.48688558
30Congenital, generalized hypertrichosis (HP:0004540)2.47650657
31Methylmalonic aciduria (HP:0012120)2.43593579
32B lymphocytopenia (HP:0010976)2.41846960
33Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40938629
34Abnormality of midbrain morphology (HP:0002418)2.39568946
35Molar tooth sign on MRI (HP:0002419)2.39568946
36Abnormality of T cell physiology (HP:0011840)2.37357584
37Abnormality of the renal cortex (HP:0011035)2.36223334
38Optic disc pallor (HP:0000543)2.35876287
39Abnormality of the renal medulla (HP:0100957)2.35757109
40Abolished electroretinogram (ERG) (HP:0000550)2.33412836
41Severe combined immunodeficiency (HP:0004430)2.33184453
42Type I transferrin isoform profile (HP:0003642)2.32200957
43IgM deficiency (HP:0002850)2.27230183
44Abnormality of eosinophils (HP:0001879)2.26281771
45Abnormality of alanine metabolism (HP:0010916)2.21533334
46Hyperalaninemia (HP:0003348)2.21533334
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21533334
48Stomach cancer (HP:0012126)2.21248862
49Lactic acidosis (HP:0003128)2.21197011
50Type 2 muscle fiber atrophy (HP:0003554)2.13252556
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11687468
52Aplastic anemia (HP:0001915)2.10878538
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09039338
54Abnormality of the pons (HP:0007361)2.09018419
55Progressive inability to walk (HP:0002505)2.08979559
56Eosinophilia (HP:0001880)2.06034311
57Attenuation of retinal blood vessels (HP:0007843)2.04854056
58True hermaphroditism (HP:0010459)2.04749587
59Abnormality of the prostate (HP:0008775)2.04282281
60Supernumerary spleens (HP:0009799)2.02458574
61Constricted visual fields (HP:0001133)2.02374519
62Retrobulbar optic neuritis (HP:0100654)2.02305040
63Optic neuritis (HP:0100653)2.02305040
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.01112317
65Renal Fanconi syndrome (HP:0001994)2.00704748
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.00043277
67Panhypogammaglobulinemia (HP:0003139)1.97132040
68Respiratory failure (HP:0002878)1.96971929
69Lethargy (HP:0001254)1.94176683
70Autoimmune hemolytic anemia (HP:0001890)1.92378191
71Leukodystrophy (HP:0002415)1.92198191
72Abnormality of macular pigmentation (HP:0008002)1.92086179
73Pendular nystagmus (HP:0012043)1.88481218
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88247248
75Increased intramyocellular lipid droplets (HP:0012240)1.88198923
76Abnormality of methionine metabolism (HP:0010901)1.87787901
77Facial diplegia (HP:0001349)1.87758400
78Microvesicular hepatic steatosis (HP:0001414)1.87405563
79Renal cortical cysts (HP:0000803)1.84486981
80Parakeratosis (HP:0001036)1.84363325
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84197356
82Abnormal protein N-linked glycosylation (HP:0012347)1.82963151
83Abnormal protein glycosylation (HP:0012346)1.82963151
84Abnormal glycosylation (HP:0012345)1.82963151
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82963151
86Abnormal spermatogenesis (HP:0008669)1.82033898
87Hypoplasia of the pons (HP:0012110)1.81558266
88Autoimmune thrombocytopenia (HP:0001973)1.80757647
89Abnormality of the ileum (HP:0001549)1.79941550
90Meckel diverticulum (HP:0002245)1.79829039
91Pancytopenia (HP:0001876)1.79403716
92Inability to walk (HP:0002540)1.78611246
93Type II lissencephaly (HP:0007260)1.77987072
94Abnormality of the labia minora (HP:0012880)1.77300424
95Abnormality of the vitamin B12 metabolism (HP:0004341)1.76932471
96Hyperglycinuria (HP:0003108)1.75546747
97Combined immunodeficiency (HP:0005387)1.75055504
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.73848956
99Absent/shortened dynein arms (HP:0200106)1.73848956
100Abnormality of vitamin B metabolism (HP:0004340)1.73458482

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.17992405
2NUAK12.98715637
3ZAK2.90951946
4FRK2.85031439
5TSSK62.63017861
6TAOK32.58729875
7TXK2.57775950
8EIF2AK32.53494114
9PLK32.05220753
10SRPK12.05132579
11VRK21.98921807
12TLK11.94982564
13MAP4K21.89961446
14EIF2AK11.89153473
15MKNK21.87565775
16MKNK11.77196626
17OXSR11.65278324
18STK161.65039582
19NME11.59667056
20ADRBK21.56736464
21TEC1.54855829
22BMPR21.53690815
23TRIM281.47010228
24BUB11.46520921
25GRK11.46277836
26VRK11.45535904
27PLK21.44537660
28STK38L1.41128433
29BMPR1B1.37432238
30ACVR1B1.34317817
31MAP3K121.28919263
32PBK1.28875524
33EIF2AK21.28523669
34PINK11.28256998
35WNK31.26118773
36NEK11.22808300
37TAF11.19564934
38CDK191.19223704
39ITK1.15214858
40STK391.08255682
41BCKDK1.04973030
42WNK41.03773400
43PASK1.03004382
44KIT0.98649628
45LATS10.97711692
46PIK3CG0.97665600
47NLK0.97217288
48ERBB30.95892461
49IKBKE0.94078592
50PLK40.92265548
51GRK60.91229425
52TNIK0.89502258
53PDK20.87900563
54ALK0.87585805
55IRAK40.86950549
56IRAK10.84967563
57MATK0.82779891
58MAP3K140.82163263
59CSNK1A1L0.81856609
60BCR0.77452356
61GRK50.77065580
62IKBKB0.76963571
63PTK2B0.69390705
64FES0.67936900
65CSNK1G30.64789415
66TIE10.63804929
67CSNK1G10.62748799
68STK30.62698979
69SYK0.62066832
70PLK10.61611749
71BTK0.61284311
72RPS6KA50.60381501
73MAP2K60.60297083
74STK40.60080990
75CSNK1G20.57383040
76JAK30.57222586
77MAP4K10.55039326
78CAMKK20.54432046
79ATR0.53942728
80DYRK20.52895672
81DAPK20.52803823
82ADRBK10.52438539
83AURKB0.49801177
84CDC70.49321908
85LYN0.48824268
86LCK0.47436099
87BRSK20.46747916
88PRKCE0.45303851
89TTK0.42642438
90DAPK10.41739145
91PAK30.40757033
92WEE10.39331499
93PRKCQ0.39130009
94INSRR0.38499636
95CSF1R0.38293808
96CSK0.38046560
97CLK10.37954207
98CSNK2A10.37497863
99IGF1R0.37331899
100TRPM70.37174570

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.42158478
2Asthma_Homo sapiens_hsa053103.41688106
3Protein export_Homo sapiens_hsa030603.40237505
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66617745
5Oxidative phosphorylation_Homo sapiens_hsa001902.61371676
6Allograft rejection_Homo sapiens_hsa053302.53696962
7RNA polymerase_Homo sapiens_hsa030202.51721856
8Autoimmune thyroid disease_Homo sapiens_hsa053202.37482774
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.35332656
10Parkinsons disease_Homo sapiens_hsa050122.31464115
11Basal transcription factors_Homo sapiens_hsa030222.15157944
12Homologous recombination_Homo sapiens_hsa034402.07131144
13Graft-versus-host disease_Homo sapiens_hsa053321.92060702
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91624076
15One carbon pool by folate_Homo sapiens_hsa006701.91551313
16Type I diabetes mellitus_Homo sapiens_hsa049401.89653922
17RNA degradation_Homo sapiens_hsa030181.89651478
18Primary immunodeficiency_Homo sapiens_hsa053401.87437523
19Mismatch repair_Homo sapiens_hsa034301.69914407
20Phototransduction_Homo sapiens_hsa047441.68196631
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56080292
22Propanoate metabolism_Homo sapiens_hsa006401.55483821
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54821247
24Ribosome_Homo sapiens_hsa030101.53148183
25RNA transport_Homo sapiens_hsa030131.52412000
26Non-homologous end-joining_Homo sapiens_hsa034501.52255281
27Spliceosome_Homo sapiens_hsa030401.49974679
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45630677
29Antigen processing and presentation_Homo sapiens_hsa046121.37664812
30Huntingtons disease_Homo sapiens_hsa050161.37421048
31Base excision repair_Homo sapiens_hsa034101.33519814
32DNA replication_Homo sapiens_hsa030301.32104361
33Alzheimers disease_Homo sapiens_hsa050101.31224090
34Fanconi anemia pathway_Homo sapiens_hsa034601.30821733
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.29989728
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23238341
37Nucleotide excision repair_Homo sapiens_hsa034201.21615907
38Pyrimidine metabolism_Homo sapiens_hsa002401.19303307
39Linoleic acid metabolism_Homo sapiens_hsa005911.14883816
40Purine metabolism_Homo sapiens_hsa002301.07752843
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06152559
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05125889
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03083928
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00418239
45Hematopoietic cell lineage_Homo sapiens_hsa046400.97412705
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94035577
47Caffeine metabolism_Homo sapiens_hsa002320.93853375
48Nitrogen metabolism_Homo sapiens_hsa009100.93676627
49Regulation of autophagy_Homo sapiens_hsa041400.92147203
50Tryptophan metabolism_Homo sapiens_hsa003800.91087262
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90423860
52Rheumatoid arthritis_Homo sapiens_hsa053230.87144686
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85960465
54Peroxisome_Homo sapiens_hsa041460.83650235
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76180137
56Sulfur metabolism_Homo sapiens_hsa009200.75764077
57Butanoate metabolism_Homo sapiens_hsa006500.71175033
58Ether lipid metabolism_Homo sapiens_hsa005650.67299022
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66541837
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65926805
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.65256293
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64219070
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62896847
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58856535
65Leishmaniasis_Homo sapiens_hsa051400.55941518
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55726067
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.55502313
68Arachidonic acid metabolism_Homo sapiens_hsa005900.55353889
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53380753
70Metabolic pathways_Homo sapiens_hsa011000.53038556
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52221589
72Selenocompound metabolism_Homo sapiens_hsa004500.52201255
73Glutathione metabolism_Homo sapiens_hsa004800.51995084
74Epstein-Barr virus infection_Homo sapiens_hsa051690.51719980
75Chemical carcinogenesis_Homo sapiens_hsa052040.51012597
76Viral myocarditis_Homo sapiens_hsa054160.50900942
77Pyruvate metabolism_Homo sapiens_hsa006200.49275822
78Systemic lupus erythematosus_Homo sapiens_hsa053220.49256868
79p53 signaling pathway_Homo sapiens_hsa041150.48974762
80T cell receptor signaling pathway_Homo sapiens_hsa046600.48093658
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47895279
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.46811093
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46412702
84Herpes simplex infection_Homo sapiens_hsa051680.46020128
85Cardiac muscle contraction_Homo sapiens_hsa042600.45408902
86Measles_Homo sapiens_hsa051620.44860338
87Collecting duct acid secretion_Homo sapiens_hsa049660.43032210
88Olfactory transduction_Homo sapiens_hsa047400.42030830
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41538363
90Taste transduction_Homo sapiens_hsa047420.39726801
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38254961
92Legionellosis_Homo sapiens_hsa051340.37887058
93Vitamin digestion and absorption_Homo sapiens_hsa049770.36613059
94Retinol metabolism_Homo sapiens_hsa008300.35876186
95Fatty acid elongation_Homo sapiens_hsa000620.34948569
96beta-Alanine metabolism_Homo sapiens_hsa004100.34010485
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32062624
98Fatty acid degradation_Homo sapiens_hsa000710.31087645
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.30390539
100Staphylococcus aureus infection_Homo sapiens_hsa051500.29401943

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