NPM1P36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.21107970
2DNA deamination (GO:0045006)6.10204548
3rRNA modification (GO:0000154)5.26348632
4ribosome assembly (GO:0042255)4.97740295
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.88355249
6rRNA methylation (GO:0031167)4.84228189
7maturation of 5.8S rRNA (GO:0000460)4.77445081
8IMP biosynthetic process (GO:0006188)4.73745131
9exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.66602786
10cullin deneddylation (GO:0010388)4.59602472
11nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.40128692
12chaperone-mediated protein transport (GO:0072321)4.33823843
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.29825994
14somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.15504058
15somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.15504058
16isotype switching (GO:0045190)4.15504058
17protein deneddylation (GO:0000338)4.10845065
18regulation of cellular amino acid metabolic process (GO:0006521)4.05446263
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.03851558
20signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.00765272
21signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.00765272
22signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.00765272
23signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.96605062
24intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.96605062
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.94328817
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.90380055
27IMP metabolic process (GO:0046040)3.87214153
28negative regulation of ligase activity (GO:0051352)3.87028883
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.87028883
30water-soluble vitamin biosynthetic process (GO:0042364)3.83000160
31signal transduction involved in DNA damage checkpoint (GO:0072422)3.82518367
32signal transduction involved in DNA integrity checkpoint (GO:0072401)3.82518367
33RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.79942242
34positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.77107233
35signal transduction involved in cell cycle checkpoint (GO:0072395)3.76338970
36regulation of chronic inflammatory response (GO:0002676)3.74535997
37amino acid activation (GO:0043038)3.71221449
38tRNA aminoacylation (GO:0043039)3.71221449
39transcription from mitochondrial promoter (GO:0006390)3.70919515
40respiratory chain complex IV assembly (GO:0008535)3.69617232
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.68954786
42chromatin remodeling at centromere (GO:0031055)3.68831056
43DNA replication checkpoint (GO:0000076)3.66306285
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.65857297
45ribosome biogenesis (GO:0042254)3.65315746
46GTP biosynthetic process (GO:0006183)3.63013729
47CENP-A containing nucleosome assembly (GO:0034080)3.62280359
48pseudouridine synthesis (GO:0001522)3.61145875
49folic acid-containing compound biosynthetic process (GO:0009396)3.60855258
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.59805555
51tRNA aminoacylation for protein translation (GO:0006418)3.59604535
52rRNA processing (GO:0006364)3.57143405
53nucleobase biosynthetic process (GO:0046112)3.52867591
54DNA catabolic process, exonucleolytic (GO:0000738)3.51612208
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51238064
56ATP synthesis coupled proton transport (GO:0015986)3.51238064
57protein neddylation (GO:0045116)3.50736711
58rRNA metabolic process (GO:0016072)3.48254659
59purine nucleobase biosynthetic process (GO:0009113)3.47772270
60protein complex biogenesis (GO:0070271)3.47617902
61transcription elongation from RNA polymerase I promoter (GO:0006362)3.47192324
62mitochondrial respiratory chain complex assembly (GO:0033108)3.45863747
63pteridine-containing compound biosynthetic process (GO:0042559)3.44173169
64regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.43369921
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42612705
66mitochondrial respiratory chain complex I assembly (GO:0032981)3.42612705
67NADH dehydrogenase complex assembly (GO:0010257)3.42612705
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.38607192
69mitotic metaphase plate congression (GO:0007080)3.37590646
70UTP biosynthetic process (GO:0006228)3.36990845
71mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33820793
72regulation of mitotic spindle checkpoint (GO:1903504)3.32456640
73regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32456640
74termination of RNA polymerase III transcription (GO:0006386)3.31918051
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.31918051
76positive regulation of ligase activity (GO:0051351)3.27602458
77somatic recombination of immunoglobulin gene segments (GO:0016447)3.26285206
78termination of RNA polymerase I transcription (GO:0006363)3.25565441
79protein targeting to mitochondrion (GO:0006626)3.25381093
80tRNA metabolic process (GO:0006399)3.24219770
81cytidine metabolic process (GO:0046087)3.22604296
82cytidine catabolic process (GO:0006216)3.22604296
83cytidine deamination (GO:0009972)3.22604296
84DNA damage response, detection of DNA damage (GO:0042769)3.21415255
85mitochondrial RNA metabolic process (GO:0000959)3.17299222
86regulation of immunoglobulin secretion (GO:0051023)3.16272941
87somatic diversification of immunoglobulins (GO:0016445)3.16112545
88positive regulation of cell cycle arrest (GO:0071158)3.14690657
89histone exchange (GO:0043486)3.13685802
90regulation of helicase activity (GO:0051095)3.13109755
91guanosine-containing compound biosynthetic process (GO:1901070)3.11084935
92cytochrome complex assembly (GO:0017004)3.10796572
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10062042
94tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10062042
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.09261221
96DNA double-strand break processing (GO:0000729)3.07834941
97positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.07210359
98tRNA processing (GO:0008033)3.05431077
99UTP metabolic process (GO:0046051)3.04823504
100ncRNA metabolic process (GO:0034660)3.03764037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.74518823
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.73286659
3E2F7_22180533_ChIP-Seq_HELA_Human4.39536369
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.00168838
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56857684
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36540386
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.25777542
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.10571874
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10018694
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.03234341
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98959754
12VDR_23849224_ChIP-Seq_CD4+_Human2.90634344
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59099862
14ELK1_19687146_ChIP-ChIP_HELA_Human2.51860902
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.45941863
16FOXP3_21729870_ChIP-Seq_TREG_Human2.38229852
17VDR_22108803_ChIP-Seq_LS180_Human2.36849114
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30894809
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27693282
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25093560
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22525284
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16101563
23ZNF274_21170338_ChIP-Seq_K562_Hela2.05370739
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05037866
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01368833
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99878370
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96312751
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.93101541
29EWS_26573619_Chip-Seq_HEK293_Human1.93006016
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.92501992
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.91639304
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90503077
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.89255367
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89017798
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.85778462
36DCP1A_22483619_ChIP-Seq_HELA_Human1.81034601
37TTF2_22483619_ChIP-Seq_HELA_Human1.79298048
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72821060
39MYC_18940864_ChIP-ChIP_HL60_Human1.72570750
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70595903
41GABP_19822575_ChIP-Seq_HepG2_Human1.67627222
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61712550
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60731265
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56725369
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53134319
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50405815
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50158575
48TAF15_26573619_Chip-Seq_HEK293_Human1.40476159
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40273385
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40109456
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38100746
52XRN2_22483619_ChIP-Seq_HELA_Human1.34306525
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31841386
54AR_21909140_ChIP-Seq_LNCAP_Human1.31755411
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31281526
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28482213
57ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27384176
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.27205850
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25533745
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24734207
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23767870
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23565074
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21513038
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15541646
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13157871
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11749224
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.10757266
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.09406033
69TP53_22573176_ChIP-Seq_HFKS_Human1.08376093
70FUS_26573619_Chip-Seq_HEK293_Human1.08024608
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05235065
72NANOG_19829295_ChIP-Seq_ESCs_Human1.02550677
73SOX2_19829295_ChIP-Seq_ESCs_Human1.02550677
74FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99170028
75FOXA1_25329375_ChIP-Seq_VCAP_Human0.99170028
76P300_19829295_ChIP-Seq_ESCs_Human0.99116820
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98637889
78IGF1R_20145208_ChIP-Seq_DFB_Human0.98222289
79NANOG_16153702_ChIP-ChIP_HESCs_Human0.97637523
80GATA1_22025678_ChIP-Seq_K562_Human0.95209882
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91285201
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90565962
83IRF1_19129219_ChIP-ChIP_H3396_Human0.89881639
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88971403
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88764649
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.87912292
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87849087
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85468026
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85243858
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84966010
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83628519
92GATA3_26560356_Chip-Seq_TH2_Human0.81243917
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80561365
94KDM5A_27292631_Chip-Seq_BREAST_Human0.80304830
95HOXB7_26014856_ChIP-Seq_BT474_Human0.80109787
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79595722
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78543004
98ELF5_23300383_ChIP-Seq_T47D_Human0.78258777
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77559727
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77431137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.82048858
2MP0003693_abnormal_embryo_hatching3.55648854
3MP0004957_abnormal_blastocyst_morpholog3.48878836
4MP0008058_abnormal_DNA_repair3.47777659
5MP0002102_abnormal_ear_morphology3.34044550
6MP0000685_abnormal_immune_system3.33925084
7MP0008057_abnormal_DNA_replication2.76837715
8MP0001835_abnormal_antigen_presentation2.72303062
9MP0003786_premature_aging2.57752390
10MP0003718_maternal_effect2.51607151
11MP0008877_abnormal_DNA_methylation2.36868836
12MP0003806_abnormal_nucleotide_metabolis2.32983739
13MP0003077_abnormal_cell_cycle2.30688888
14MP0004145_abnormal_muscle_electrophysio2.16686484
15MP0008007_abnormal_cellular_replicative2.13493808
16MP0003111_abnormal_nucleus_morphology2.09828528
17MP0003567_abnormal_fetal_cardiomyocyte2.02951260
18MP0006292_abnormal_olfactory_placode2.00510407
19MP0006036_abnormal_mitochondrial_physio1.99042391
20MP0002736_abnormal_nociception_after1.97013523
21MP0006035_abnormal_mitochondrial_morpho1.92584013
22MP0005084_abnormal_gallbladder_morpholo1.92390354
23MP0002138_abnormal_hepatobiliary_system1.82618446
24MP0009697_abnormal_copulation1.77361603
25MP0003646_muscle_fatigue1.75599298
26MP0008872_abnormal_physiological_respon1.75332360
27MP0003195_calcinosis1.74970569
28MP0001853_heart_inflammation1.60822011
29MP0008875_abnormal_xenobiotic_pharmacok1.57745130
30MP0008932_abnormal_embryonic_tissue1.55606690
31MP0001293_anophthalmia1.49657839
32MP0001968_abnormal_touch/_nociception1.48251849
33MP0000372_irregular_coat_pigmentation1.34629269
34MP0002006_tumorigenesis1.33709322
35MP0001501_abnormal_sleep_pattern1.33432458
36MP0002148_abnormal_hypersensitivity_rea1.33304732
37MP0001529_abnormal_vocalization1.26969456
38MP0002160_abnormal_reproductive_system1.24684573
39MP0003878_abnormal_ear_physiology1.23578577
40MP0005377_hearing/vestibular/ear_phenot1.23578577
41MP0005671_abnormal_response_to1.17626937
42MP0003186_abnormal_redox_activity1.10994845
43MP0005387_immune_system_phenotype1.08582645
44MP0001790_abnormal_immune_system1.08582645
45MP0001485_abnormal_pinna_reflex1.08236994
46MP0006072_abnormal_retinal_apoptosis1.07185542
47MP0003252_abnormal_bile_duct1.04310922
48MP0009764_decreased_sensitivity_to1.03021255
49MP0004084_abnormal_cardiac_muscle1.00627788
50MP0002837_dystrophic_cardiac_calcinosis0.98930120
51MP0005389_reproductive_system_phenotype0.98214221
52MP0005636_abnormal_mineral_homeostasis0.97346726
53MP0009785_altered_susceptibility_to0.97155116
54MP0002163_abnormal_gland_morphology0.96947373
55MP0004147_increased_porphyrin_level0.96512781
56MP0000358_abnormal_cell_content/0.93972950
57MP0002210_abnormal_sex_determination0.93123590
58MP0002166_altered_tumor_susceptibility0.92204584
59MP0005165_increased_susceptibility_to0.90259280
60MP0004215_abnormal_myocardial_fiber0.90233978
61MP0009333_abnormal_splenocyte_physiolog0.90216131
62MP0005645_abnormal_hypothalamus_physiol0.89882881
63MP0003011_delayed_dark_adaptation0.88881112
64MP0001697_abnormal_embryo_size0.88370095
65MP0003937_abnormal_limbs/digits/tail_de0.88090834
66MP0001929_abnormal_gametogenesis0.87386095
67MP0001348_abnormal_lacrimal_gland0.85532029
68MP0006054_spinal_hemorrhage0.84816784
69MP0005395_other_phenotype0.83527300
70MP0001730_embryonic_growth_arrest0.83010252
71MP0001119_abnormal_female_reproductive0.78343835
72MP0001800_abnormal_humoral_immune0.76459342
73MP0010386_abnormal_urinary_bladder0.76257754
74MP0005085_abnormal_gallbladder_physiolo0.76112135
75MP0001905_abnormal_dopamine_level0.75470993
76MP0000647_abnormal_sebaceous_gland0.75061122
77MP0002254_reproductive_system_inflammat0.73821764
78MP0002938_white_spotting0.73781071
79MP0002751_abnormal_autonomic_nervous0.73694107
80MP0005379_endocrine/exocrine_gland_phen0.73496584
81MP0002396_abnormal_hematopoietic_system0.73105281
82MP0002277_abnormal_respiratory_mucosa0.71837861
83MP0005380_embryogenesis_phenotype0.71606761
84MP0001672_abnormal_embryogenesis/_devel0.71606761
85MP0000653_abnormal_sex_gland0.71540823
86MP0003890_abnormal_embryonic-extraembry0.71317061
87MP0008789_abnormal_olfactory_epithelium0.71203645
88MP0004133_heterotaxia0.69846393
89MP0005332_abnormal_amino_acid0.68449902
90MP0002019_abnormal_tumor_incidence0.66931923
91MP0003119_abnormal_digestive_system0.66702027
92MP0005551_abnormal_eye_electrophysiolog0.66316946
93MP0001881_abnormal_mammary_gland0.65986706
94MP0002405_respiratory_system_inflammati0.65619266
95MP0000689_abnormal_spleen_morphology0.65504526
96MP0003936_abnormal_reproductive_system0.64928153
97MP0000490_abnormal_crypts_of0.64451979
98MP0000427_abnormal_hair_cycle0.64197623
99MP0001764_abnormal_homeostasis0.64105269
100MP0001145_abnormal_male_reproductive0.63946958

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.75175233
2Increased CSF lactate (HP:0002490)4.14916117
3Acute encephalopathy (HP:0006846)4.09969799
4Progressive macrocephaly (HP:0004481)3.98721098
5Abnormal mitochondria in muscle tissue (HP:0008316)3.94072565
6Stomatitis (HP:0010280)3.87528283
7Mitochondrial inheritance (HP:0001427)3.86753935
8Increased hepatocellular lipid droplets (HP:0006565)3.70716920
9Increased serum pyruvate (HP:0003542)3.55544336
10Methylmalonic acidemia (HP:0002912)3.52299423
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.47454616
12Abnormality of alanine metabolism (HP:0010916)3.47454616
13Hyperalaninemia (HP:0003348)3.47454616
14Cerebral edema (HP:0002181)3.31468961
15Lipid accumulation in hepatocytes (HP:0006561)3.26301588
16Hepatocellular necrosis (HP:0001404)3.25649028
17Abnormality of glycolysis (HP:0004366)3.21935636
18Abnormality of the labia minora (HP:0012880)3.18805856
19Cerebral hypomyelination (HP:0006808)3.12628821
20Premature ovarian failure (HP:0008209)3.09225352
21Hepatic necrosis (HP:0002605)3.08327352
22Increased serum lactate (HP:0002151)2.98145178
23Microvesicular hepatic steatosis (HP:0001414)2.94092269
24Colon cancer (HP:0003003)2.92332705
253-Methylglutaconic aciduria (HP:0003535)2.90875856
26Methylmalonic aciduria (HP:0012120)2.88002428
27Pancreatic cysts (HP:0001737)2.79310325
28Congenital, generalized hypertrichosis (HP:0004540)2.76948451
29Optic disc pallor (HP:0000543)2.71800395
30Renal Fanconi syndrome (HP:0001994)2.70681439
31Abnormality of the pons (HP:0007361)2.63561826
32Hypoplasia of the pons (HP:0012110)2.62839614
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57037919
34Leukodystrophy (HP:0002415)2.48452782
35Supernumerary spleens (HP:0009799)2.47789180
36Respiratory difficulties (HP:0002880)2.42195716
37Bile duct proliferation (HP:0001408)2.39094746
38Abnormal biliary tract physiology (HP:0012439)2.39094746
39Meckel diverticulum (HP:0002245)2.36074307
40Lactic acidosis (HP:0003128)2.35170760
41Lethargy (HP:0001254)2.34646322
42Secondary amenorrhea (HP:0000869)2.34338987
43Multiple enchondromatosis (HP:0005701)2.33982238
44Birth length less than 3rd percentile (HP:0003561)2.26397055
45Type 2 muscle fiber atrophy (HP:0003554)2.24209337
46Neoplasm of the adrenal gland (HP:0100631)2.19125214
47Exertional dyspnea (HP:0002875)2.19122531
48Molar tooth sign on MRI (HP:0002419)2.19009026
49Abnormality of midbrain morphology (HP:0002418)2.19009026
50Increased IgM level (HP:0003496)2.18869917
51Abnormality of the ileum (HP:0001549)2.17415419
52Respiratory failure (HP:0002878)2.16323374
53Abnormality of methionine metabolism (HP:0010901)2.14771996
54Exercise intolerance (HP:0003546)2.14660567
55IgG deficiency (HP:0004315)2.14615044
56Abnormality of serum amino acid levels (HP:0003112)2.13978502
57CNS demyelination (HP:0007305)2.12444108
58Paralysis (HP:0003470)2.11902052
59CNS hypomyelination (HP:0003429)2.10909104
60Pancreatic fibrosis (HP:0100732)2.09590404
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07630647
62Abnormality of the anterior horn cell (HP:0006802)2.05820959
63Degeneration of anterior horn cells (HP:0002398)2.05820959
64Nausea (HP:0002018)2.05805069
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.04138926
66Dicarboxylic aciduria (HP:0003215)1.98961038
67Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98961038
68Abnormality of the preputium (HP:0100587)1.98500037
69Abnormality of the vitamin B12 metabolism (HP:0004341)1.98044770
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97510869
71Muscle fiber atrophy (HP:0100295)1.92569676
72Glycosuria (HP:0003076)1.92533692
73Abnormality of urine glucose concentration (HP:0011016)1.92533692
74Oral leukoplakia (HP:0002745)1.92440712
75Pancytopenia (HP:0001876)1.92417700
76Pendular nystagmus (HP:0012043)1.91291504
77Prostate neoplasm (HP:0100787)1.90640006
78Ependymoma (HP:0002888)1.89186900
79Amniotic constriction ring (HP:0009775)1.87638227
80Abnormality of placental membranes (HP:0011409)1.87638227
81Testicular atrophy (HP:0000029)1.87057153
82Abnormality of vitamin B metabolism (HP:0004340)1.86932830
83Cleft eyelid (HP:0000625)1.85979695
84Hypomagnesemia (HP:0002917)1.85300963
85Opisthotonus (HP:0002179)1.85145476
86Prominent metopic ridge (HP:0005487)1.83717088
87Clubbing of toes (HP:0100760)1.83381745
88Agnosia (HP:0010524)1.80954659
89Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80196221
90Hyperglycinuria (HP:0003108)1.79413806
91Horseshoe kidney (HP:0000085)1.78988667
92Abnormality of T cell physiology (HP:0011840)1.78530912
93Abnormality of chromosome stability (HP:0003220)1.78340908
94True hermaphroditism (HP:0010459)1.78253654
95Abnormality of serine family amino acid metabolism (HP:0010894)1.77873978
96Abnormality of glycine metabolism (HP:0010895)1.77873978
97Duodenal stenosis (HP:0100867)1.77031273
98Small intestinal stenosis (HP:0012848)1.77031273
99Progressive microcephaly (HP:0000253)1.76630516
100Nephronophthisis (HP:0000090)1.75951878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.26271351
2MST44.05773300
3VRK23.90225584
4EIF2AK13.34601962
5TAF13.25943489
6EIF2AK33.20055916
7BUB12.88659186
8TRIM282.87386133
9NEK12.66790727
10NUAK12.64826823
11STK162.48875935
12PLK32.48255225
13ZAK2.14205507
14VRK12.04221641
15PBK2.03814410
16NME12.03772259
17FRK2.01243692
18MKNK22.00294479
19MKNK11.92981954
20SRPK11.82122999
21PLK21.74261674
22CDC71.73820831
23ADRBK21.70655634
24BMPR1B1.64239530
25TTK1.46189801
26PLK41.43248015
27OXSR11.41383700
28GRK11.38848641
29ALK1.35920484
30EIF2AK21.35409900
31PDK21.33570316
32TLK11.24355934
33DAPK11.24202015
34ACVR1B1.16652117
35PASK1.15396695
36SMG11.11962807
37MAPKAPK51.11836590
38BCKDK1.06881883
39STK391.06111799
40PLK11.05969488
41WNK31.02364252
42DAPK21.00872579
43MAPKAPK31.00019346
44TNIK0.99818130
45WNK40.98602121
46WEE10.91737729
47TAOK30.91262303
48CSNK1A1L0.87508632
49CSNK1G30.86808050
50DYRK20.86253182
51PAK40.84270657
52CSNK1G10.82235399
53MAP4K20.76467405
54CSNK1G20.75476013
55TGFBR10.73868858
56ATR0.73804403
57TEC0.70441534
58PHKG10.70264433
59PHKG20.70264433
60PNCK0.67903459
61SIK30.62892058
62AURKB0.62129368
63PINK10.59768202
64INSRR0.57165083
65NME20.56097954
66RPS6KA40.55951512
67CDK190.55191904
68STK40.54669002
69TXK0.53366629
70RPS6KB20.51840340
71FGFR10.44771079
72DAPK30.44322415
73BCR0.43023193
74IKBKB0.42305313
75CSNK1E0.42102579
76GRK50.40729380
77CSNK2A10.38632024
78CSNK2A20.38346805
79CDK70.38346250
80CHEK20.38160119
81PRKCI0.36224129
82RPS6KA50.35757099
83PRKCG0.35319542
84STK100.35282310
85ATM0.35205418
86CHEK10.34398515
87PRKCQ0.32055488
88BRSK20.29930253
89CDK60.29004403
90TIE10.26783661
91CDK80.25724478
92MAP3K80.24824830
93ADRBK10.22037359
94PRKCE0.20649250
95CSNK1A10.17182701
96STK38L0.16967436
97CAMK2A0.16209551
98PRKDC0.16116031
99ERBB30.15914447
100STK30.15382264

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.25813391
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79403904
3Protein export_Homo sapiens_hsa030602.84454835
4Mismatch repair_Homo sapiens_hsa034302.79472023
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.72339108
6RNA polymerase_Homo sapiens_hsa030202.60179959
7RNA degradation_Homo sapiens_hsa030182.48656040
8DNA replication_Homo sapiens_hsa030302.47548521
9One carbon pool by folate_Homo sapiens_hsa006702.46653255
10Vitamin B6 metabolism_Homo sapiens_hsa007502.43348550
11Oxidative phosphorylation_Homo sapiens_hsa001902.36652585
12Basal transcription factors_Homo sapiens_hsa030222.25530697
13RNA transport_Homo sapiens_hsa030132.23530995
14Parkinsons disease_Homo sapiens_hsa050122.14805182
15Asthma_Homo sapiens_hsa053102.12555778
16Homologous recombination_Homo sapiens_hsa034402.10475422
17Ribosome_Homo sapiens_hsa030102.06911988
18Non-homologous end-joining_Homo sapiens_hsa034501.94620943
19Propanoate metabolism_Homo sapiens_hsa006401.83460209
20Base excision repair_Homo sapiens_hsa034101.80740549
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80427816
22Nucleotide excision repair_Homo sapiens_hsa034201.80394111
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.61506322
24Pyrimidine metabolism_Homo sapiens_hsa002401.56891808
25Spliceosome_Homo sapiens_hsa030401.54999885
26Huntingtons disease_Homo sapiens_hsa050161.51319035
27Type I diabetes mellitus_Homo sapiens_hsa049401.48693264
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.42583656
29Fanconi anemia pathway_Homo sapiens_hsa034601.38005758
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37334261
31Allograft rejection_Homo sapiens_hsa053301.35573698
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35434582
33Pyruvate metabolism_Homo sapiens_hsa006201.30480496
34Alzheimers disease_Homo sapiens_hsa050101.27539500
35Purine metabolism_Homo sapiens_hsa002301.26993292
36Autoimmune thyroid disease_Homo sapiens_hsa053201.26980356
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24786127
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22079220
39Primary immunodeficiency_Homo sapiens_hsa053401.22013188
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07049441
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03310523
42Sulfur metabolism_Homo sapiens_hsa009201.00279080
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00081983
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99479789
45Glutathione metabolism_Homo sapiens_hsa004800.84380582
46Folate biosynthesis_Homo sapiens_hsa007900.82614910
47Graft-versus-host disease_Homo sapiens_hsa053320.74443995
48Cell cycle_Homo sapiens_hsa041100.73968720
49Selenocompound metabolism_Homo sapiens_hsa004500.73513796
50Caffeine metabolism_Homo sapiens_hsa002320.72910778
51Steroid biosynthesis_Homo sapiens_hsa001000.72348222
52Linoleic acid metabolism_Homo sapiens_hsa005910.70816461
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70652059
54mRNA surveillance pathway_Homo sapiens_hsa030150.69949686
55Epstein-Barr virus infection_Homo sapiens_hsa051690.69677115
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65437780
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64403793
58Peroxisome_Homo sapiens_hsa041460.61370530
59Fatty acid elongation_Homo sapiens_hsa000620.57982697
60Butanoate metabolism_Homo sapiens_hsa006500.57616691
61Phototransduction_Homo sapiens_hsa047440.55653746
62Metabolic pathways_Homo sapiens_hsa011000.55640067
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.55624668
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55533912
65Carbon metabolism_Homo sapiens_hsa012000.53190670
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53082213
67Cardiac muscle contraction_Homo sapiens_hsa042600.52939844
68Tryptophan metabolism_Homo sapiens_hsa003800.51980130
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51716293
70Ether lipid metabolism_Homo sapiens_hsa005650.50863715
71Rheumatoid arthritis_Homo sapiens_hsa053230.50836542
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49088468
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47406910
74Antigen processing and presentation_Homo sapiens_hsa046120.46419881
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41472425
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40480205
77Hematopoietic cell lineage_Homo sapiens_hsa046400.39946042
78beta-Alanine metabolism_Homo sapiens_hsa004100.39239775
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39145636
80p53 signaling pathway_Homo sapiens_hsa041150.38753307
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38680399
82Sulfur relay system_Homo sapiens_hsa041220.38314803
83Biosynthesis of amino acids_Homo sapiens_hsa012300.37203564
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34154524
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33533167
86Systemic lupus erythematosus_Homo sapiens_hsa053220.33147331
87Fatty acid degradation_Homo sapiens_hsa000710.30537748
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30157967
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29724672
90Arachidonic acid metabolism_Homo sapiens_hsa005900.29506092
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26797862
92Retinol metabolism_Homo sapiens_hsa008300.26031192
93Chemical carcinogenesis_Homo sapiens_hsa052040.25320750
94Collecting duct acid secretion_Homo sapiens_hsa049660.24254595
95Olfactory transduction_Homo sapiens_hsa047400.23820510
96Viral myocarditis_Homo sapiens_hsa054160.23524295
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.22856491
98Nitrogen metabolism_Homo sapiens_hsa009100.20972277
99Vitamin digestion and absorption_Homo sapiens_hsa049770.20773706
100Herpes simplex infection_Homo sapiens_hsa051680.20109938

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