ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.54331955
2	proteasome assembly (GO:0043248)	4.43776090
3	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.26646665
4	rRNA modification (GO:0000154)	4.22180442
5	regulation of isotype switching to IgG isotypes (GO:0048302)	4.16795590
6	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.98855937
7	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.79187310
8	pseudouridine synthesis (GO:0001522)	3.75287261
9	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.72383561
10	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.70175075
11	amino acid salvage (GO:0043102)	3.69835450
12	L-methionine salvage (GO:0071267)	3.69835450
13	L-methionine biosynthetic process (GO:0071265)	3.69835450
14	maturation of 5.8S rRNA (GO:0000460)	3.62626637
15	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.42301935
16	respiratory chain complex IV assembly (GO:0008535)	3.41434543
17	rRNA methylation (GO:0031167)	3.38374181
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.33781126
19	regulation of regulatory T cell differentiation (GO:0045589)	3.29374067
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.23269098
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.23269098
22	NADH dehydrogenase complex assembly (GO:0010257)	3.23269098
23	fucose catabolic process (GO:0019317)	3.23216854
24	L-fucose metabolic process (GO:0042354)	3.23216854
25	L-fucose catabolic process (GO:0042355)	3.23216854
26	rRNA catabolic process (GO:0016075)	3.22179489
27	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.17801973
28	protein complex biogenesis (GO:0070271)	3.17014701
29	regulation of cellular amino acid metabolic process (GO:0006521)	3.13782216
30	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.13323008
31	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.13323008
32	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.13323008
33	response to pheromone (GO:0019236)	3.13007534
34	peptidyl-histidine modification (GO:0018202)	3.09595027
35	cullin deneddylation (GO:0010388)	3.09389664
36	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.09006524
37	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.09006524
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.08202113
39	regulation of immunoglobulin secretion (GO:0051023)	3.08143991
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.07838166
41	ribosome assembly (GO:0042255)	3.07801157
42	cytidine metabolic process (GO:0046087)	3.03381373
43	cytidine catabolic process (GO:0006216)	3.03381373
44	cytidine deamination (GO:0009972)	3.03381373
45	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.02877092
46	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.01565617
47	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.01565617
48	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.97205077
49	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.97205077
50	positive regulation of DNA recombination (GO:0045911)	2.95705623
51	protein deneddylation (GO:0000338)	2.92980068
52	DNA catabolic process, exonucleolytic (GO:0000738)	2.91946534
53	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.91808888
54	regulation of chronic inflammatory response (GO:0002676)	2.91621120
55	methionine biosynthetic process (GO:0009086)	2.89614373
56	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.87752887
57	viral mRNA export from host cell nucleus (GO:0046784)	2.87118479
58	GTP biosynthetic process (GO:0006183)	2.83783130
59	mitochondrial RNA metabolic process (GO:0000959)	2.82607518
60	cytochrome complex assembly (GO:0017004)	2.82498078
61	termination of RNA polymerase III transcription (GO:0006386)	2.82207048
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.82207048
63	DNA double-strand break processing (GO:0000729)	2.80071170
64	GMP metabolic process (GO:0046037)	2.79691257
65	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.77260068
66	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.77260068
67	isotype switching (GO:0045190)	2.77260068
68	positive regulation of isotype switching (GO:0045830)	2.75915219
69	ribosome biogenesis (GO:0042254)	2.74391538
70	mismatch repair (GO:0006298)	2.72559240
71	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.70845839
72	DNA demethylation (GO:0080111)	2.69845797
73	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.69377172
74	negative regulation of ligase activity (GO:0051352)	2.69377172
75	rRNA metabolic process (GO:0016072)	2.68725520
76	termination of RNA polymerase I transcription (GO:0006363)	2.67680896
77	rRNA processing (GO:0006364)	2.67541750
78	tRNA processing (GO:0008033)	2.67270958
79	regulation of B cell apoptotic process (GO:0002902)	2.64032041
80	RNA phosphodiester bond hydrolysis (GO:0090501)	2.61433589
81	tRNA metabolic process (GO:0006399)	2.59342779
82	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.58403563
83	prenylation (GO:0097354)	2.58264007
84	protein prenylation (GO:0018342)	2.58264007
85	positive regulation of defense response to virus by host (GO:0002230)	2.56314430
86	positive regulation of interleukin-17 production (GO:0032740)	2.56264139
87	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.55977284
88	regulation of mitotic spindle checkpoint (GO:1903504)	2.55977284
89	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.55617164
90	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.54897001
91	UTP metabolic process (GO:0046051)	2.54288245
92	tRNA modification (GO:0006400)	2.54111091
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.54023343
94	methionine metabolic process (GO:0006555)	2.53420740
95	synapsis (GO:0007129)	2.52971888
96	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.52772372
97	piRNA metabolic process (GO:0034587)	2.52549332
98	IMP biosynthetic process (GO:0006188)	2.50395268
99	CENP-A containing nucleosome assembly (GO:0034080)	2.50378729
100	S-adenosylmethionine metabolic process (GO:0046500)	2.50034910

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.29263887
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.01775806
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.35099665
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.31427599
5	VDR_23849224_ChIP-Seq_CD4+_Human	2.80586806
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.67165214
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.64563434
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.55316528
9	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.54819515
10	VDR_22108803_ChIP-Seq_LS180_Human	2.52945585
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.47280907
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.44515488
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.41087344
14	E2F7_22180533_ChIP-Seq_HELA_Human	2.37053875
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.32789134
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.29957967
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28198605
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.21730862
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.13169370
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.12938107
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.03690412
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.97829576
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95579411
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.93126830
25	GATA1_22025678_ChIP-Seq_K562_Human	1.92005880
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.91393929
27	EWS_26573619_Chip-Seq_HEK293_Human	1.89707423
28	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.87556675
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.87061346
30	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.76132647
31	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.76017604
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.71513365
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.71155681
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.69560547
35	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.68224685
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.67289353
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60001289
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.57266462
39	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.54578568
40	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.50750932
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.47457586
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.46562700
43	FUS_26573619_Chip-Seq_HEK293_Human	1.46231183
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45130204
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42318948
46	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.41714001
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.39231165
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35097958
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.34523700
50	P300_19829295_ChIP-Seq_ESCs_Human	1.32227424
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31505504
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.30855746
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.30087038
54	MYB_26560356_Chip-Seq_TH2_Human	1.27921097
55	GATA3_26560356_Chip-Seq_TH2_Human	1.27713164
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26013426
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26013426
58	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.25384409
59	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.22068131
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20200767
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.18538927
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18538927
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16641495
64	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.16599528
65	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.15747783
66	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.15309642
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.14835023
68	GABP_19822575_ChIP-Seq_HepG2_Human	1.12104144
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11250639
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11250639
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10682456
72	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.08577814
73	TTF2_22483619_ChIP-Seq_HELA_Human	1.07381088
74	AR_20517297_ChIP-Seq_VCAP_Human	1.07118008
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06297205
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05026603
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03685059
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03571740
79	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.01752744
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01719072
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01176136
82	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.00254955
83	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99666242
84	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.98732807
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.97505931
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97024212
87	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.96291884
88	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.96237202
89	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.95705897
90	SPI1_23547873_ChIP-Seq_NB4_Human	0.93563892
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.92936313
92	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.92297401
93	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.91168084
94	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.91045556
95	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.90776615
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90371810
97	P300_18555785_Chip-Seq_ESCs_Mouse	0.89199929
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.88937316
99	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.88903171
100	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88156177

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.42791060
2	MP0008877_abnormal_DNA_methylation	3.18645863
3	MP0002138_abnormal_hepatobiliary_system	2.88617623
4	MP0004147_increased_porphyrin_level	2.54999442
5	MP0003718_maternal_effect	2.45936418
6	MP0008057_abnormal_DNA_replication	2.42990586
7	MP0005671_abnormal_response_to	2.35747546
8	MP0008872_abnormal_physiological_respon	2.32522620
9	MP0008058_abnormal_DNA_repair	2.31851719
10	MP0005646_abnormal_pituitary_gland	2.16667347
11	MP0002837_dystrophic_cardiac_calcinosis	2.06748523
12	MP0002102_abnormal_ear_morphology	2.01366714
13	MP0003787_abnormal_imprinting	1.97648938
14	MP0008875_abnormal_xenobiotic_pharmacok	1.95297244
15	MP0000685_abnormal_immune_system	1.92028645
16	MP0001873_stomach_inflammation	1.91926244
17	MP0003195_calcinosis	1.91743298
18	MP0000372_irregular_coat_pigmentation	1.87676411
19	MP0002148_abnormal_hypersensitivity_rea	1.81439907
20	MP0000569_abnormal_digit_pigmentation	1.79137535
21	MP0001800_abnormal_humoral_immune	1.79040520
22	MP0003786_premature_aging	1.72297364
23	MP0005075_abnormal_melanosome_morpholog	1.70810176
24	MP0009785_altered_susceptibility_to	1.68210076
25	MP0001968_abnormal_touch/_nociception	1.68119648
26	MP0005645_abnormal_hypothalamus_physiol	1.65295259
27	MP0002132_abnormal_respiratory_system	1.65009272
28	MP0006036_abnormal_mitochondrial_physio	1.61894685
29	MP0009333_abnormal_splenocyte_physiolog	1.59709394
30	MP0009697_abnormal_copulation	1.56642448
31	MP0002163_abnormal_gland_morphology	1.56528470
32	MP0001661_extended_life_span	1.55936036
33	MP0003724_increased_susceptibility_to	1.55654720
34	MP0006072_abnormal_retinal_apoptosis	1.51642673
35	MP0003806_abnormal_nucleotide_metabolis	1.50754604
36	MP0004145_abnormal_muscle_electrophysio	1.50067008
37	MP0005084_abnormal_gallbladder_morpholo	1.49227132
38	MP0010094_abnormal_chromosome_stability	1.46991585
39	MP0005000_abnormal_immune_tolerance	1.45499722
40	MP0005387_immune_system_phenotype	1.38422632
41	MP0001790_abnormal_immune_system	1.38422632
42	MP0002736_abnormal_nociception_after	1.36344716
43	MP0003186_abnormal_redox_activity	1.35602038
44	MP0002723_abnormal_immune_serum	1.31784079
45	MP0004957_abnormal_blastocyst_morpholog	1.31763879
46	MP0002277_abnormal_respiratory_mucosa	1.31696162
47	MP0001853_heart_inflammation	1.26587127
48	MP0002876_abnormal_thyroid_physiology	1.26374758
49	MP0004782_abnormal_surfactant_physiolog	1.24733819
50	MP0002452_abnormal_antigen_presenting	1.21420278
51	MP0003763_abnormal_thymus_physiology	1.21232829
52	MP0000689_abnormal_spleen_morphology	1.18596029
53	MP0001764_abnormal_homeostasis	1.16938900
54	MP0003693_abnormal_embryo_hatching	1.16640555
55	MP0002006_tumorigenesis	1.16303125
56	MP0009764_decreased_sensitivity_to	1.15794138
57	MP0003646_muscle_fatigue	1.14336252
58	MP0002420_abnormal_adaptive_immunity	1.13063319
59	MP0005551_abnormal_eye_electrophysiolog	1.11001853
60	MP0002166_altered_tumor_susceptibility	1.10598733
61	MP0001819_abnormal_immune_cell	1.09235209
62	MP0006292_abnormal_olfactory_placode	1.08600566
63	MP0002398_abnormal_bone_marrow	1.08462544
64	MP0003866_abnormal_defecation	1.05867801
65	MP0003567_abnormal_fetal_cardiomyocyte	1.04772627
66	MP0002405_respiratory_system_inflammati	1.03816017
67	MP0006035_abnormal_mitochondrial_morpho	1.02739180
68	MP0005636_abnormal_mineral_homeostasis	1.00565918
69	MP0000716_abnormal_immune_system	0.96835995
70	MP0005253_abnormal_eye_physiology	0.96292862
71	MP0002396_abnormal_hematopoietic_system	0.96259506
72	MP0005379_endocrine/exocrine_gland_phen	0.95945205
73	MP0005085_abnormal_gallbladder_physiolo	0.95292236
74	MP0001986_abnormal_taste_sensitivity	0.94931888
75	MP0002722_abnormal_immune_system	0.92032320
76	MP0008995_early_reproductive_senescence	0.89659530
77	MP0001845_abnormal_inflammatory_respons	0.88840797
78	MP0002693_abnormal_pancreas_physiology	0.88429068
79	MP0000427_abnormal_hair_cycle	0.87827392
80	MP0002429_abnormal_blood_cell	0.87647162
81	MP0008775_abnormal_heart_ventricle	0.86170311
82	MP0000703_abnormal_thymus_morphology	0.84806977
83	MP0008469_abnormal_protein_level	0.83963138
84	MP0005389_reproductive_system_phenotype	0.83117521
85	MP0005410_abnormal_fertilization	0.80104103
86	MP0001881_abnormal_mammary_gland	0.79426913
87	MP0002160_abnormal_reproductive_system	0.77680162
88	MP0010155_abnormal_intestine_physiology	0.77079886
89	MP0006082_CNS_inflammation	0.76066471
90	MP0004142_abnormal_muscle_tone	0.75345346
91	MP0004215_abnormal_myocardial_fiber	0.73258947
92	MP0004484_altered_response_of	0.72979162
93	MP0001529_abnormal_vocalization	0.72325934
94	MP0003436_decreased_susceptibility_to	0.72037562
95	MP0005395_other_phenotype	0.71190487
96	MP0001119_abnormal_female_reproductive	0.70919128
97	MP0001501_abnormal_sleep_pattern	0.70696317
98	MP0002019_abnormal_tumor_incidence	0.68890563
99	MP0008873_increased_physiological_sensi	0.67664162
100	MP0003252_abnormal_bile_duct	0.66969407

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.94494728
2	Increased CSF lactate (HP:0002490)	3.79277971
3	Mitochondrial inheritance (HP:0001427)	3.65668097
4	Increased hepatocellular lipid droplets (HP:0006565)	3.60589911
5	Progressive macrocephaly (HP:0004481)	3.51488200
6	Acute encephalopathy (HP:0006846)	3.34251766
7	Stomatitis (HP:0010280)	3.33181458
8	Lipid accumulation in hepatocytes (HP:0006561)	3.31251265
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.24648706
10	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.10971247
11	Abnormality of alanine metabolism (HP:0010916)	3.10971247
12	Hyperalaninemia (HP:0003348)	3.10971247
13	Hepatocellular necrosis (HP:0001404)	2.97728134
14	IgG deficiency (HP:0004315)	2.95151844
15	Decreased central vision (HP:0007663)	2.94563072
16	Hepatic necrosis (HP:0002605)	2.87063236
17	Increased serum lactate (HP:0002151)	2.83453036
18	Cerebral edema (HP:0002181)	2.82568750
19	Abolished electroretinogram (ERG) (HP:0000550)	2.71746521
20	Pancreatic cysts (HP:0001737)	2.66982504
21	Exertional dyspnea (HP:0002875)	2.53415420
22	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.50568695
23	Methylmalonic acidemia (HP:0002912)	2.48856459
24	Abnormality of midbrain morphology (HP:0002418)	2.45385050
25	Molar tooth sign on MRI (HP:0002419)	2.45385050
26	3-Methylglutaconic aciduria (HP:0003535)	2.42266637
27	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.41742844
28	Abnormal protein glycosylation (HP:0012346)	2.40053160
29	Abnormal glycosylation (HP:0012345)	2.40053160
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.40053160
31	Abnormal protein N-linked glycosylation (HP:0012347)	2.40053160
32	Abnormality of the pons (HP:0007361)	2.39488528
33	Aplastic anemia (HP:0001915)	2.38946027
34	Elevated erythrocyte sedimentation rate (HP:0003565)	2.37986324
35	Degeneration of anterior horn cells (HP:0002398)	2.35163349
36	Abnormality of the anterior horn cell (HP:0006802)	2.35163349
37	Abnormality of T cell physiology (HP:0011840)	2.34349988
38	Congenital stationary night blindness (HP:0007642)	2.33690042
39	Congenital, generalized hypertrichosis (HP:0004540)	2.32980401
40	Lactic acidosis (HP:0003128)	2.32181066
41	Optic disc pallor (HP:0000543)	2.30205787
42	Methylmalonic aciduria (HP:0012120)	2.29627506
43	Tongue fasciculations (HP:0001308)	2.27795004
44	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.27562773
45	Thyroiditis (HP:0100646)	2.24566736
46	Renal Fanconi syndrome (HP:0001994)	2.24496442
47	Constricted visual fields (HP:0001133)	2.24228969
48	Abnormality of B cell number (HP:0010975)	2.21611991
49	Abnormality of T cells (HP:0002843)	2.21510201
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.20657173
51	Lethargy (HP:0001254)	2.17316667
52	Respiratory failure (HP:0002878)	2.15910437
53	Severe combined immunodeficiency (HP:0004430)	2.15171755
54	Abnormality of the prostate (HP:0008775)	2.14973475
55	Type I transferrin isoform profile (HP:0003642)	2.14892900
56	Attenuation of retinal blood vessels (HP:0007843)	2.13069737
57	Hypothermia (HP:0002045)	2.10066321
58	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.09903893
59	Pancreatic fibrosis (HP:0100732)	2.09198423
60	Pancytopenia (HP:0001876)	2.08412608
61	Large for gestational age (HP:0001520)	2.07083355
62	Hypoplasia of the pons (HP:0012110)	2.06469125
63	Hypoproteinemia (HP:0003075)	2.06282879
64	Carpal bone hypoplasia (HP:0001498)	2.05595439
65	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.05163784
66	Type 2 muscle fiber atrophy (HP:0003554)	2.04904290
67	Short middle phalanx of the 5th finger (HP:0004220)	2.02260619
68	Renal cortical cysts (HP:0000803)	2.00558172
69	Abnormality of serum amino acid levels (HP:0003112)	1.99076801
70	Nephronophthisis (HP:0000090)	1.98798985
71	B lymphocytopenia (HP:0010976)	1.98466012
72	True hermaphroditism (HP:0010459)	1.96278953
73	Abnormal rod and cone electroretinograms (HP:0008323)	1.96020359
74	Abnormality of macular pigmentation (HP:0008002)	1.94717133
75	Increased intramyocellular lipid droplets (HP:0012240)	1.94633340
76	Chronic diarrhea (HP:0002028)	1.93228350
77	Abnormality of T cell number (HP:0011839)	1.93218170
78	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.93202385
79	Abnormality of the renal cortex (HP:0011035)	1.92947502
80	Abnormality of the renal collecting system (HP:0004742)	1.91365602
81	Spinal muscular atrophy (HP:0007269)	1.90879050
82	Abnormality of the labia minora (HP:0012880)	1.89892557
83	Muscle fibrillation (HP:0010546)	1.89322581
84	Hyperglycinuria (HP:0003108)	1.86977626
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.86880339
86	Type II lissencephaly (HP:0007260)	1.85509795
87	Duplicated collecting system (HP:0000081)	1.84531425
88	Respiratory difficulties (HP:0002880)	1.83088511
89	Keratoconus (HP:0000563)	1.82909637
90	Increased corneal curvature (HP:0100692)	1.82909637
91	Neutropenia (HP:0001875)	1.82269288
92	T lymphocytopenia (HP:0005403)	1.82190158
93	Autoimmune hemolytic anemia (HP:0001890)	1.81698401
94	Reduced antithrombin III activity (HP:0001976)	1.80803942
95	Progressive microcephaly (HP:0000253)	1.80205772
96	Abnormality of methionine metabolism (HP:0010901)	1.79905772
97	Exercise intolerance (HP:0003546)	1.79413595
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.79139004
99	Central scotoma (HP:0000603)	1.77888567
100	Colon cancer (HP:0003003)	1.75546786

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	3.90732850
2	MST4	3.47513949
3	NUAK1	3.40460875
4	EIF2AK1	3.16548124
5	TXK	2.69067991
6	INSRR	2.69043232
7	TSSK6	2.67018193
8	FRK	2.55924170
9	ZAK	2.40506337
10	VRK2	2.22884014
11	BMPR1B	2.17416609
12	TAOK3	2.16026359
13	ADRBK2	2.15486948
14	MKNK1	2.05201487
15	TLK1	1.91248564
16	MKNK2	1.86715348
17	VRK1	1.85586601
18	PLK3	1.80288811
19	STK16	1.74250691
20	OXSR1	1.71463718
21	MAP4K2	1.68121167
22	ACVR1B	1.61930516
23	TEC	1.56226028
24	GRK1	1.48529562
25	SRPK1	1.48386441
26	TNIK	1.48102934
27	PDK2	1.34079998
28	WNK3	1.31227612
29	TRIM28	1.23750386
30	BUB1	1.23136506
31	TAF1	1.21039126
32	WNK4	1.20592455
33	STK39	1.18828785
34	BCKDK	1.18635734
35	EIF2AK2	1.17667448
36	ITK	1.10228219
37	MAPKAPK5	1.06704416
38	IKBKB	1.06281070
39	PLK2	1.01851445
40	CDK8	1.01369147
41	PBK	1.00974247
42	TIE1	0.99759735
43	NEK1	0.98740999
44	BMPR2	0.98331741
45	CDK19	0.95574539
46	IRAK4	0.89788599
47	TGFBR1	0.87319874
48	PHKG2	0.86909913
49	PHKG1	0.86909913
50	NLK	0.83115668
51	NME1	0.80364075
52	KIT	0.76622205
53	IRAK1	0.75179527
54	DAPK2	0.74714043
55	TRPM7	0.74094903
56	SYK	0.74044380
57	RPS6KA5	0.73798314
58	STK4	0.68501412
59	PLK4	0.65432696
60	DAPK1	0.64971556
61	MAPKAPK3	0.64306105
62	ERBB3	0.62974837
63	IKBKE	0.61162630
64	PASK	0.60688359
65	FES	0.60354436
66	MAP3K14	0.59415659
67	ALK	0.59221318
68	ADRBK1	0.58300437
69	CDC7	0.57534985
70	PLK1	0.56990833
71	PRKCQ	0.53244132
72	ATR	0.52076917
73	BTK	0.50546439
74	PIK3CG	0.49551749
75	LCK	0.46219046
76	CHUK	0.46195792
77	CAMKK2	0.45984534
78	RIPK4	0.45336129
79	MAP3K4	0.45229430
80	CLK1	0.43856706
81	PRKCE	0.43389842
82	CSNK1G3	0.42972550
83	AKT3	0.42948385
84	CSNK1A1L	0.41864641
85	GRK5	0.41450020
86	PINK1	0.41380025
87	CSNK1G1	0.41322855
88	MATK	0.38373272
89	JAK3	0.38241019
90	FLT3	0.36602325
91	NME2	0.36446071
92	LYN	0.34776851
93	RPS6KB2	0.33290722
94	AURKB	0.32457635
95	BRD4	0.32171971
96	OBSCN	0.32000882
97	CSNK2A2	0.31619550
98	CSF1R	0.31609988
99	WNK1	0.30359264
100	PAK3	0.29649649

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.42829064
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.23247505
3	Protein export_Homo sapiens_hsa03060	3.15087497
4	Asthma_Homo sapiens_hsa05310	2.98916531
5	Allograft rejection_Homo sapiens_hsa05330	2.63959136
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.47421552
7	RNA polymerase_Homo sapiens_hsa03020	2.32868842
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.21350932
9	RNA degradation_Homo sapiens_hsa03018	2.17182395
10	One carbon pool by folate_Homo sapiens_hsa00670	2.13004851
11	Basal transcription factors_Homo sapiens_hsa03022	2.10828392
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.06791928
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.98435307
14	Homologous recombination_Homo sapiens_hsa03440	1.95520235
15	Mismatch repair_Homo sapiens_hsa03430	1.87420876
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.86499102
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84531755
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.83079786
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.81673303
20	RNA transport_Homo sapiens_hsa03013	1.79906264
21	Parkinsons disease_Homo sapiens_hsa05012	1.70412672
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.65732939
23	Propanoate metabolism_Homo sapiens_hsa00640	1.58417353
24	DNA replication_Homo sapiens_hsa03030	1.55383623
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.48989908
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42685040
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.41779407
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.40493399
29	Spliceosome_Homo sapiens_hsa03040	1.34775461
30	Ribosome_Homo sapiens_hsa03010	1.33220846
31	Phototransduction_Homo sapiens_hsa04744	1.33219765
32	Base excision repair_Homo sapiens_hsa03410	1.31979685
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.29447302
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29335400
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26641826
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.24420131
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.22705014
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22493155
39	Purine metabolism_Homo sapiens_hsa00230	1.19335414
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.17173951
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.13831184
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.11625073
43	Antigen processing and presentation_Homo sapiens_hsa04612	1.09349071
44	Regulation of autophagy_Homo sapiens_hsa04140	1.07997001
45	Huntingtons disease_Homo sapiens_hsa05016	1.02365528
46	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01318805
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.93965135
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.92901369
49	Caffeine metabolism_Homo sapiens_hsa00232	0.91688488
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90633065
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90337978
52	Butanoate metabolism_Homo sapiens_hsa00650	0.87726228
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.87593206
54	Peroxisome_Homo sapiens_hsa04146	0.87019214
55	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.86828978
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.84917862
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84509343
58	Alzheimers disease_Homo sapiens_hsa05010	0.82118548
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78084691
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.75764930
61	Fatty acid elongation_Homo sapiens_hsa00062	0.74643836
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.73682569
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.73553255
64	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.70173543
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69466165
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68467688
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.66373504
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64159419
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63378532
70	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.61907685
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56138027
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56081868
73	Measles_Homo sapiens_hsa05162	0.55947033
74	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55941977
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53111474
76	Metabolic pathways_Homo sapiens_hsa01100	0.52204775
77	p53 signaling pathway_Homo sapiens_hsa04115	0.50891327
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49731692
79	Olfactory transduction_Homo sapiens_hsa04740	0.47471178
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47383143
81	Herpes simplex infection_Homo sapiens_hsa05168	0.45678761
82	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.43767461
83	Legionellosis_Homo sapiens_hsa05134	0.42471690
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42193741
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.39772917
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.38716492
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38033877
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37659495
89	Sulfur metabolism_Homo sapiens_hsa00920	0.36321322
90	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.35838210
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.35361972
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.33919162
93	Taste transduction_Homo sapiens_hsa04742	0.33537847
94	Retinol metabolism_Homo sapiens_hsa00830	0.33004705
95	Leishmaniasis_Homo sapiens_hsa05140	0.32198732
96	Mineral absorption_Homo sapiens_hsa04978	0.31406838
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.31385625
98	Viral myocarditis_Homo sapiens_hsa05416	0.31099345
99	mRNA surveillance pathway_Homo sapiens_hsa03015	0.30970007
100	Glutathione metabolism_Homo sapiens_hsa00480	0.29398776

NPM1P37

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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