NPM1P37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.54331955
2proteasome assembly (GO:0043248)4.43776090
3L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.26646665
4rRNA modification (GO:0000154)4.22180442
5regulation of isotype switching to IgG isotypes (GO:0048302)4.16795590
6RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.98855937
7exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.79187310
8pseudouridine synthesis (GO:0001522)3.75287261
9nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72383561
10positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.70175075
11amino acid salvage (GO:0043102)3.69835450
12L-methionine salvage (GO:0071267)3.69835450
13L-methionine biosynthetic process (GO:0071265)3.69835450
14maturation of 5.8S rRNA (GO:0000460)3.62626637
15regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.42301935
16respiratory chain complex IV assembly (GO:0008535)3.41434543
17rRNA methylation (GO:0031167)3.38374181
18water-soluble vitamin biosynthetic process (GO:0042364)3.33781126
19regulation of regulatory T cell differentiation (GO:0045589)3.29374067
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23269098
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.23269098
22NADH dehydrogenase complex assembly (GO:0010257)3.23269098
23fucose catabolic process (GO:0019317)3.23216854
24L-fucose metabolic process (GO:0042354)3.23216854
25L-fucose catabolic process (GO:0042355)3.23216854
26rRNA catabolic process (GO:0016075)3.22179489
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17801973
28protein complex biogenesis (GO:0070271)3.17014701
29regulation of cellular amino acid metabolic process (GO:0006521)3.13782216
30signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13323008
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13323008
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13323008
33response to pheromone (GO:0019236)3.13007534
34peptidyl-histidine modification (GO:0018202)3.09595027
35cullin deneddylation (GO:0010388)3.09389664
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09006524
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09006524
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08202113
39regulation of immunoglobulin secretion (GO:0051023)3.08143991
40mitochondrial respiratory chain complex assembly (GO:0033108)3.07838166
41ribosome assembly (GO:0042255)3.07801157
42cytidine metabolic process (GO:0046087)3.03381373
43cytidine catabolic process (GO:0006216)3.03381373
44cytidine deamination (GO:0009972)3.03381373
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02877092
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01565617
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01565617
48signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97205077
49signal transduction involved in DNA damage checkpoint (GO:0072422)2.97205077
50positive regulation of DNA recombination (GO:0045911)2.95705623
51protein deneddylation (GO:0000338)2.92980068
52DNA catabolic process, exonucleolytic (GO:0000738)2.91946534
53signal transduction involved in cell cycle checkpoint (GO:0072395)2.91808888
54regulation of chronic inflammatory response (GO:0002676)2.91621120
55methionine biosynthetic process (GO:0009086)2.89614373
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87752887
57viral mRNA export from host cell nucleus (GO:0046784)2.87118479
58GTP biosynthetic process (GO:0006183)2.83783130
59mitochondrial RNA metabolic process (GO:0000959)2.82607518
60cytochrome complex assembly (GO:0017004)2.82498078
61transcription elongation from RNA polymerase III promoter (GO:0006385)2.82207048
62termination of RNA polymerase III transcription (GO:0006386)2.82207048
63DNA double-strand break processing (GO:0000729)2.80071170
64GMP metabolic process (GO:0046037)2.79691257
65isotype switching (GO:0045190)2.77260068
66somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.77260068
67somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.77260068
68positive regulation of isotype switching (GO:0045830)2.75915219
69ribosome biogenesis (GO:0042254)2.74391538
70mismatch repair (GO:0006298)2.72559240
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70845839
72DNA demethylation (GO:0080111)2.69845797
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69377172
74negative regulation of ligase activity (GO:0051352)2.69377172
75rRNA metabolic process (GO:0016072)2.68725520
76termination of RNA polymerase I transcription (GO:0006363)2.67680896
77rRNA processing (GO:0006364)2.67541750
78tRNA processing (GO:0008033)2.67270958
79regulation of B cell apoptotic process (GO:0002902)2.64032041
80RNA phosphodiester bond hydrolysis (GO:0090501)2.61433589
81tRNA metabolic process (GO:0006399)2.59342779
82establishment of protein localization to mitochondrial membrane (GO:0090151)2.58403563
83prenylation (GO:0097354)2.58264007
84protein prenylation (GO:0018342)2.58264007
85positive regulation of defense response to virus by host (GO:0002230)2.56314430
86positive regulation of interleukin-17 production (GO:0032740)2.56264139
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.55977284
88regulation of mitotic spindle checkpoint (GO:1903504)2.55977284
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.55617164
90transcription elongation from RNA polymerase I promoter (GO:0006362)2.54897001
91UTP metabolic process (GO:0046051)2.54288245
92tRNA modification (GO:0006400)2.54111091
93preassembly of GPI anchor in ER membrane (GO:0016254)2.54023343
94methionine metabolic process (GO:0006555)2.53420740
95synapsis (GO:0007129)2.52971888
96pyrimidine ribonucleoside catabolic process (GO:0046133)2.52772372
97piRNA metabolic process (GO:0034587)2.52549332
98IMP biosynthetic process (GO:0006188)2.50395268
99CENP-A containing nucleosome assembly (GO:0034080)2.50378729
100S-adenosylmethionine metabolic process (GO:0046500)2.50034910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29263887
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.01775806
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.35099665
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.31427599
5VDR_23849224_ChIP-Seq_CD4+_Human2.80586806
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67165214
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.64563434
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55316528
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54819515
10VDR_22108803_ChIP-Seq_LS180_Human2.52945585
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47280907
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44515488
13ZNF274_21170338_ChIP-Seq_K562_Hela2.41087344
14E2F7_22180533_ChIP-Seq_HELA_Human2.37053875
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32789134
16ELK1_19687146_ChIP-ChIP_HELA_Human2.29957967
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.28198605
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.21730862
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13169370
20FOXP3_21729870_ChIP-Seq_TREG_Human2.12938107
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03690412
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97829576
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95579411
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93126830
25GATA1_22025678_ChIP-Seq_K562_Human1.92005880
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.91393929
27EWS_26573619_Chip-Seq_HEK293_Human1.89707423
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87556675
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87061346
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.76132647
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76017604
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71513365
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71155681
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69560547
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.68224685
36IGF1R_20145208_ChIP-Seq_DFB_Human1.67289353
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60001289
38TAF15_26573619_Chip-Seq_HEK293_Human1.57266462
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54578568
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50750932
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47457586
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46562700
43FUS_26573619_Chip-Seq_HEK293_Human1.46231183
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45130204
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.42318948
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.41714001
47TP53_22573176_ChIP-Seq_HFKS_Human1.39231165
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35097958
49ER_23166858_ChIP-Seq_MCF-7_Human1.34523700
50P300_19829295_ChIP-Seq_ESCs_Human1.32227424
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.31505504
52DCP1A_22483619_ChIP-Seq_HELA_Human1.30855746
53MYC_18940864_ChIP-ChIP_HL60_Human1.30087038
54MYB_26560356_Chip-Seq_TH2_Human1.27921097
55GATA3_26560356_Chip-Seq_TH2_Human1.27713164
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.26013426
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26013426
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25384409
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22068131
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20200767
61CBP_20019798_ChIP-Seq_JUKART_Human1.18538927
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18538927
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16641495
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16599528
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15747783
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15309642
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14835023
68GABP_19822575_ChIP-Seq_HepG2_Human1.12104144
69SOX2_19829295_ChIP-Seq_ESCs_Human1.11250639
70NANOG_19829295_ChIP-Seq_ESCs_Human1.11250639
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.10682456
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08577814
73TTF2_22483619_ChIP-Seq_HELA_Human1.07381088
74AR_20517297_ChIP-Seq_VCAP_Human1.07118008
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06297205
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05026603
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03685059
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03571740
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01752744
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01719072
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01176136
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00254955
83IRF1_19129219_ChIP-ChIP_H3396_Human0.99666242
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98732807
85STAT3_18555785_Chip-Seq_ESCs_Mouse0.97505931
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97024212
87SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96291884
88BP1_19119308_ChIP-ChIP_Hs578T_Human0.96237202
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95705897
90SPI1_23547873_ChIP-Seq_NB4_Human0.93563892
91P53_22387025_ChIP-Seq_ESCs_Mouse0.92936313
92IRF8_21731497_ChIP-ChIP_J774_Mouse0.92297401
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91168084
94OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91045556
95OCT4_18555785_Chip-Seq_ESCs_Mouse0.90776615
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90371810
97P300_18555785_Chip-Seq_ESCs_Mouse0.89199929
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88937316
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88903171
100E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88156177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.42791060
2MP0008877_abnormal_DNA_methylation3.18645863
3MP0002138_abnormal_hepatobiliary_system2.88617623
4MP0004147_increased_porphyrin_level2.54999442
5MP0003718_maternal_effect2.45936418
6MP0008057_abnormal_DNA_replication2.42990586
7MP0005671_abnormal_response_to2.35747546
8MP0008872_abnormal_physiological_respon2.32522620
9MP0008058_abnormal_DNA_repair2.31851719
10MP0005646_abnormal_pituitary_gland2.16667347
11MP0002837_dystrophic_cardiac_calcinosis2.06748523
12MP0002102_abnormal_ear_morphology2.01366714
13MP0003787_abnormal_imprinting1.97648938
14MP0008875_abnormal_xenobiotic_pharmacok1.95297244
15MP0000685_abnormal_immune_system1.92028645
16MP0001873_stomach_inflammation1.91926244
17MP0003195_calcinosis1.91743298
18MP0000372_irregular_coat_pigmentation1.87676411
19MP0002148_abnormal_hypersensitivity_rea1.81439907
20MP0000569_abnormal_digit_pigmentation1.79137535
21MP0001800_abnormal_humoral_immune1.79040520
22MP0003786_premature_aging1.72297364
23MP0005075_abnormal_melanosome_morpholog1.70810176
24MP0009785_altered_susceptibility_to1.68210076
25MP0001968_abnormal_touch/_nociception1.68119648
26MP0005645_abnormal_hypothalamus_physiol1.65295259
27MP0002132_abnormal_respiratory_system1.65009272
28MP0006036_abnormal_mitochondrial_physio1.61894685
29MP0009333_abnormal_splenocyte_physiolog1.59709394
30MP0009697_abnormal_copulation1.56642448
31MP0002163_abnormal_gland_morphology1.56528470
32MP0001661_extended_life_span1.55936036
33MP0003724_increased_susceptibility_to1.55654720
34MP0006072_abnormal_retinal_apoptosis1.51642673
35MP0003806_abnormal_nucleotide_metabolis1.50754604
36MP0004145_abnormal_muscle_electrophysio1.50067008
37MP0005084_abnormal_gallbladder_morpholo1.49227132
38MP0010094_abnormal_chromosome_stability1.46991585
39MP0005000_abnormal_immune_tolerance1.45499722
40MP0001790_abnormal_immune_system1.38422632
41MP0005387_immune_system_phenotype1.38422632
42MP0002736_abnormal_nociception_after1.36344716
43MP0003186_abnormal_redox_activity1.35602038
44MP0002723_abnormal_immune_serum1.31784079
45MP0004957_abnormal_blastocyst_morpholog1.31763879
46MP0002277_abnormal_respiratory_mucosa1.31696162
47MP0001853_heart_inflammation1.26587127
48MP0002876_abnormal_thyroid_physiology1.26374758
49MP0004782_abnormal_surfactant_physiolog1.24733819
50MP0002452_abnormal_antigen_presenting1.21420278
51MP0003763_abnormal_thymus_physiology1.21232829
52MP0000689_abnormal_spleen_morphology1.18596029
53MP0001764_abnormal_homeostasis1.16938900
54MP0003693_abnormal_embryo_hatching1.16640555
55MP0002006_tumorigenesis1.16303125
56MP0009764_decreased_sensitivity_to1.15794138
57MP0003646_muscle_fatigue1.14336252
58MP0002420_abnormal_adaptive_immunity1.13063319
59MP0005551_abnormal_eye_electrophysiolog1.11001853
60MP0002166_altered_tumor_susceptibility1.10598733
61MP0001819_abnormal_immune_cell1.09235209
62MP0006292_abnormal_olfactory_placode1.08600566
63MP0002398_abnormal_bone_marrow1.08462544
64MP0003866_abnormal_defecation1.05867801
65MP0003567_abnormal_fetal_cardiomyocyte1.04772627
66MP0002405_respiratory_system_inflammati1.03816017
67MP0006035_abnormal_mitochondrial_morpho1.02739180
68MP0005636_abnormal_mineral_homeostasis1.00565918
69MP0000716_abnormal_immune_system0.96835995
70MP0005253_abnormal_eye_physiology0.96292862
71MP0002396_abnormal_hematopoietic_system0.96259506
72MP0005379_endocrine/exocrine_gland_phen0.95945205
73MP0005085_abnormal_gallbladder_physiolo0.95292236
74MP0001986_abnormal_taste_sensitivity0.94931888
75MP0002722_abnormal_immune_system0.92032320
76MP0008995_early_reproductive_senescence0.89659530
77MP0001845_abnormal_inflammatory_respons0.88840797
78MP0002693_abnormal_pancreas_physiology0.88429068
79MP0000427_abnormal_hair_cycle0.87827392
80MP0002429_abnormal_blood_cell0.87647162
81MP0008775_abnormal_heart_ventricle0.86170311
82MP0000703_abnormal_thymus_morphology0.84806977
83MP0008469_abnormal_protein_level0.83963138
84MP0005389_reproductive_system_phenotype0.83117521
85MP0005410_abnormal_fertilization0.80104103
86MP0001881_abnormal_mammary_gland0.79426913
87MP0002160_abnormal_reproductive_system0.77680162
88MP0010155_abnormal_intestine_physiology0.77079886
89MP0006082_CNS_inflammation0.76066471
90MP0004142_abnormal_muscle_tone0.75345346
91MP0004215_abnormal_myocardial_fiber0.73258947
92MP0004484_altered_response_of0.72979162
93MP0001529_abnormal_vocalization0.72325934
94MP0003436_decreased_susceptibility_to0.72037562
95MP0005395_other_phenotype0.71190487
96MP0001119_abnormal_female_reproductive0.70919128
97MP0001501_abnormal_sleep_pattern0.70696317
98MP0002019_abnormal_tumor_incidence0.68890563
99MP0008873_increased_physiological_sensi0.67664162
100MP0003252_abnormal_bile_duct0.66969407

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.94494728
2Increased CSF lactate (HP:0002490)3.79277971
3Mitochondrial inheritance (HP:0001427)3.65668097
4Increased hepatocellular lipid droplets (HP:0006565)3.60589911
5Progressive macrocephaly (HP:0004481)3.51488200
6Acute encephalopathy (HP:0006846)3.34251766
7Stomatitis (HP:0010280)3.33181458
8Lipid accumulation in hepatocytes (HP:0006561)3.31251265
9Abnormal mitochondria in muscle tissue (HP:0008316)3.24648706
10Abnormality of alanine metabolism (HP:0010916)3.10971247
11Hyperalaninemia (HP:0003348)3.10971247
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.10971247
13Hepatocellular necrosis (HP:0001404)2.97728134
14IgG deficiency (HP:0004315)2.95151844
15Decreased central vision (HP:0007663)2.94563072
16Hepatic necrosis (HP:0002605)2.87063236
17Increased serum lactate (HP:0002151)2.83453036
18Cerebral edema (HP:0002181)2.82568750
19Abolished electroretinogram (ERG) (HP:0000550)2.71746521
20Pancreatic cysts (HP:0001737)2.66982504
21Exertional dyspnea (HP:0002875)2.53415420
22Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50568695
23Methylmalonic acidemia (HP:0002912)2.48856459
24Molar tooth sign on MRI (HP:0002419)2.45385050
25Abnormality of midbrain morphology (HP:0002418)2.45385050
263-Methylglutaconic aciduria (HP:0003535)2.42266637
27Abnormality of aspartate family amino acid metabolism (HP:0010899)2.41742844
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40053160
29Abnormal protein N-linked glycosylation (HP:0012347)2.40053160
30Abnormal protein glycosylation (HP:0012346)2.40053160
31Abnormal glycosylation (HP:0012345)2.40053160
32Abnormality of the pons (HP:0007361)2.39488528
33Aplastic anemia (HP:0001915)2.38946027
34Elevated erythrocyte sedimentation rate (HP:0003565)2.37986324
35Degeneration of anterior horn cells (HP:0002398)2.35163349
36Abnormality of the anterior horn cell (HP:0006802)2.35163349
37Abnormality of T cell physiology (HP:0011840)2.34349988
38Congenital stationary night blindness (HP:0007642)2.33690042
39Congenital, generalized hypertrichosis (HP:0004540)2.32980401
40Lactic acidosis (HP:0003128)2.32181066
41Optic disc pallor (HP:0000543)2.30205787
42Methylmalonic aciduria (HP:0012120)2.29627506
43Tongue fasciculations (HP:0001308)2.27795004
44Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.27562773
45Thyroiditis (HP:0100646)2.24566736
46Renal Fanconi syndrome (HP:0001994)2.24496442
47Constricted visual fields (HP:0001133)2.24228969
48Abnormality of B cell number (HP:0010975)2.21611991
49Abnormality of T cells (HP:0002843)2.21510201
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20657173
51Lethargy (HP:0001254)2.17316667
52Respiratory failure (HP:0002878)2.15910437
53Severe combined immunodeficiency (HP:0004430)2.15171755
54Abnormality of the prostate (HP:0008775)2.14973475
55Type I transferrin isoform profile (HP:0003642)2.14892900
56Attenuation of retinal blood vessels (HP:0007843)2.13069737
57Hypothermia (HP:0002045)2.10066321
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09903893
59Pancreatic fibrosis (HP:0100732)2.09198423
60Pancytopenia (HP:0001876)2.08412608
61Large for gestational age (HP:0001520)2.07083355
62Hypoplasia of the pons (HP:0012110)2.06469125
63Hypoproteinemia (HP:0003075)2.06282879
64Carpal bone hypoplasia (HP:0001498)2.05595439
65Abnormality of the phalanges of the 5th finger (HP:0004213)2.05163784
66Type 2 muscle fiber atrophy (HP:0003554)2.04904290
67Short middle phalanx of the 5th finger (HP:0004220)2.02260619
68Renal cortical cysts (HP:0000803)2.00558172
69Abnormality of serum amino acid levels (HP:0003112)1.99076801
70Nephronophthisis (HP:0000090)1.98798985
71B lymphocytopenia (HP:0010976)1.98466012
72True hermaphroditism (HP:0010459)1.96278953
73Abnormal rod and cone electroretinograms (HP:0008323)1.96020359
74Abnormality of macular pigmentation (HP:0008002)1.94717133
75Increased intramyocellular lipid droplets (HP:0012240)1.94633340
76Chronic diarrhea (HP:0002028)1.93228350
77Abnormality of T cell number (HP:0011839)1.93218170
78Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93202385
79Abnormality of the renal cortex (HP:0011035)1.92947502
80Abnormality of the renal collecting system (HP:0004742)1.91365602
81Spinal muscular atrophy (HP:0007269)1.90879050
82Abnormality of the labia minora (HP:0012880)1.89892557
83Muscle fibrillation (HP:0010546)1.89322581
84Hyperglycinuria (HP:0003108)1.86977626
85Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86880339
86Type II lissencephaly (HP:0007260)1.85509795
87Duplicated collecting system (HP:0000081)1.84531425
88Respiratory difficulties (HP:0002880)1.83088511
89Increased corneal curvature (HP:0100692)1.82909637
90Keratoconus (HP:0000563)1.82909637
91Neutropenia (HP:0001875)1.82269288
92T lymphocytopenia (HP:0005403)1.82190158
93Autoimmune hemolytic anemia (HP:0001890)1.81698401
94Reduced antithrombin III activity (HP:0001976)1.80803942
95Progressive microcephaly (HP:0000253)1.80205772
96Abnormality of methionine metabolism (HP:0010901)1.79905772
97Exercise intolerance (HP:0003546)1.79413595
98Aplasia/hypoplasia of the uterus (HP:0008684)1.79139004
99Central scotoma (HP:0000603)1.77888567
100Colon cancer (HP:0003003)1.75546786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.90732850
2MST43.47513949
3NUAK13.40460875
4EIF2AK13.16548124
5TXK2.69067991
6INSRR2.69043232
7TSSK62.67018193
8FRK2.55924170
9ZAK2.40506337
10VRK22.22884014
11BMPR1B2.17416609
12TAOK32.16026359
13ADRBK22.15486948
14MKNK12.05201487
15TLK11.91248564
16MKNK21.86715348
17VRK11.85586601
18PLK31.80288811
19STK161.74250691
20OXSR11.71463718
21MAP4K21.68121167
22ACVR1B1.61930516
23TEC1.56226028
24GRK11.48529562
25SRPK11.48386441
26TNIK1.48102934
27PDK21.34079998
28WNK31.31227612
29TRIM281.23750386
30BUB11.23136506
31TAF11.21039126
32WNK41.20592455
33STK391.18828785
34BCKDK1.18635734
35EIF2AK21.17667448
36ITK1.10228219
37MAPKAPK51.06704416
38IKBKB1.06281070
39PLK21.01851445
40CDK81.01369147
41PBK1.00974247
42TIE10.99759735
43NEK10.98740999
44BMPR20.98331741
45CDK190.95574539
46IRAK40.89788599
47TGFBR10.87319874
48PHKG20.86909913
49PHKG10.86909913
50NLK0.83115668
51NME10.80364075
52KIT0.76622205
53IRAK10.75179527
54DAPK20.74714043
55TRPM70.74094903
56SYK0.74044380
57RPS6KA50.73798314
58STK40.68501412
59PLK40.65432696
60DAPK10.64971556
61MAPKAPK30.64306105
62ERBB30.62974837
63IKBKE0.61162630
64PASK0.60688359
65FES0.60354436
66MAP3K140.59415659
67ALK0.59221318
68ADRBK10.58300437
69CDC70.57534985
70PLK10.56990833
71PRKCQ0.53244132
72ATR0.52076917
73BTK0.50546439
74PIK3CG0.49551749
75LCK0.46219046
76CHUK0.46195792
77CAMKK20.45984534
78RIPK40.45336129
79MAP3K40.45229430
80CLK10.43856706
81PRKCE0.43389842
82CSNK1G30.42972550
83AKT30.42948385
84CSNK1A1L0.41864641
85GRK50.41450020
86PINK10.41380025
87CSNK1G10.41322855
88MATK0.38373272
89JAK30.38241019
90FLT30.36602325
91NME20.36446071
92LYN0.34776851
93RPS6KB20.33290722
94AURKB0.32457635
95BRD40.32171971
96OBSCN0.32000882
97CSNK2A20.31619550
98CSF1R0.31609988
99WNK10.30359264
100PAK30.29649649

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.42829064
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23247505
3Protein export_Homo sapiens_hsa030603.15087497
4Asthma_Homo sapiens_hsa053102.98916531
5Allograft rejection_Homo sapiens_hsa053302.63959136
6Autoimmune thyroid disease_Homo sapiens_hsa053202.47421552
7RNA polymerase_Homo sapiens_hsa030202.32868842
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.21350932
9RNA degradation_Homo sapiens_hsa030182.17182395
10One carbon pool by folate_Homo sapiens_hsa006702.13004851
11Basal transcription factors_Homo sapiens_hsa030222.10828392
12Type I diabetes mellitus_Homo sapiens_hsa049402.06791928
13Oxidative phosphorylation_Homo sapiens_hsa001901.98435307
14Homologous recombination_Homo sapiens_hsa034401.95520235
15Mismatch repair_Homo sapiens_hsa034301.87420876
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86499102
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84531755
18Graft-versus-host disease_Homo sapiens_hsa053321.83079786
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81673303
20RNA transport_Homo sapiens_hsa030131.79906264
21Parkinsons disease_Homo sapiens_hsa050121.70412672
22Primary immunodeficiency_Homo sapiens_hsa053401.65732939
23Propanoate metabolism_Homo sapiens_hsa006401.58417353
24DNA replication_Homo sapiens_hsa030301.55383623
25Non-homologous end-joining_Homo sapiens_hsa034501.48989908
26Linoleic acid metabolism_Homo sapiens_hsa005911.42685040
27Nitrogen metabolism_Homo sapiens_hsa009101.41779407
28Nucleotide excision repair_Homo sapiens_hsa034201.40493399
29Spliceosome_Homo sapiens_hsa030401.34775461
30Ribosome_Homo sapiens_hsa030101.33220846
31Phototransduction_Homo sapiens_hsa047441.33219765
32Base excision repair_Homo sapiens_hsa034101.31979685
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29447302
34Pyrimidine metabolism_Homo sapiens_hsa002401.29335400
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26641826
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24420131
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.22705014
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22493155
39Purine metabolism_Homo sapiens_hsa002301.19335414
40Selenocompound metabolism_Homo sapiens_hsa004501.17173951
41Rheumatoid arthritis_Homo sapiens_hsa053231.13831184
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11625073
43Antigen processing and presentation_Homo sapiens_hsa046121.09349071
44Regulation of autophagy_Homo sapiens_hsa041401.07997001
45Huntingtons disease_Homo sapiens_hsa050161.02365528
46Fanconi anemia pathway_Homo sapiens_hsa034601.01318805
47Ether lipid metabolism_Homo sapiens_hsa005650.93965135
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92901369
49Caffeine metabolism_Homo sapiens_hsa002320.91688488
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90633065
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90337978
52Butanoate metabolism_Homo sapiens_hsa006500.87726228
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87593206
54Peroxisome_Homo sapiens_hsa041460.87019214
55Hematopoietic cell lineage_Homo sapiens_hsa046400.86828978
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.84917862
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84509343
58Alzheimers disease_Homo sapiens_hsa050100.82118548
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78084691
60Systemic lupus erythematosus_Homo sapiens_hsa053220.75764930
61Fatty acid elongation_Homo sapiens_hsa000620.74643836
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73682569
63Tryptophan metabolism_Homo sapiens_hsa003800.73553255
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.70173543
65Arachidonic acid metabolism_Homo sapiens_hsa005900.69466165
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68467688
67Vitamin B6 metabolism_Homo sapiens_hsa007500.66373504
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64159419
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63378532
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.61907685
71Collecting duct acid secretion_Homo sapiens_hsa049660.56138027
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56081868
73Measles_Homo sapiens_hsa051620.55947033
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.55941977
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.53111474
76Metabolic pathways_Homo sapiens_hsa011000.52204775
77p53 signaling pathway_Homo sapiens_hsa041150.50891327
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49731692
79Olfactory transduction_Homo sapiens_hsa047400.47471178
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47383143
81Herpes simplex infection_Homo sapiens_hsa051680.45678761
82Epstein-Barr virus infection_Homo sapiens_hsa051690.43767461
83Legionellosis_Homo sapiens_hsa051340.42471690
84Chemical carcinogenesis_Homo sapiens_hsa052040.42193741
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39772917
86T cell receptor signaling pathway_Homo sapiens_hsa046600.38716492
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.38033877
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37659495
89Sulfur metabolism_Homo sapiens_hsa009200.36321322
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35838210
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35361972
92Pyruvate metabolism_Homo sapiens_hsa006200.33919162
93Taste transduction_Homo sapiens_hsa047420.33537847
94Retinol metabolism_Homo sapiens_hsa008300.33004705
95Leishmaniasis_Homo sapiens_hsa051400.32198732
96Mineral absorption_Homo sapiens_hsa049780.31406838
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31385625
98Viral myocarditis_Homo sapiens_hsa054160.31099345
99mRNA surveillance pathway_Homo sapiens_hsa030150.30970007
100Glutathione metabolism_Homo sapiens_hsa004800.29398776

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