

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.40597893 |
| 2 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.11303202 |
| 3 | rRNA modification (GO:0000154) | 4.99667890 |
| 4 | chaperone-mediated protein transport (GO:0072321) | 4.92071586 |
| 5 | rRNA methylation (GO:0031167) | 4.48463228 |
| 6 | ribosome assembly (GO:0042255) | 4.48454837 |
| 7 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.38303087 |
| 8 | DNA deamination (GO:0045006) | 4.37995067 |
| 9 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.32937223 |
| 10 | maturation of 5.8S rRNA (GO:0000460) | 4.18018824 |
| 11 | telomere maintenance via telomerase (GO:0007004) | 4.12916877 |
| 12 | pseudouridine synthesis (GO:0001522) | 4.04381302 |
| 13 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.98152965 |
| 14 | termination of RNA polymerase III transcription (GO:0006386) | 3.94955831 |
| 15 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.94955831 |
| 16 | spliceosomal complex assembly (GO:0000245) | 3.93532814 |
| 17 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.87407398 |
| 18 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.87407398 |
| 19 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.85889655 |
| 20 | rRNA processing (GO:0006364) | 3.82426176 |
| 21 | regulation of centriole replication (GO:0046599) | 3.76130091 |
| 22 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.75283945 |
| 23 | ATP synthesis coupled proton transport (GO:0015986) | 3.75283945 |
| 24 | mitochondrial RNA metabolic process (GO:0000959) | 3.74609069 |
| 25 | rRNA metabolic process (GO:0016072) | 3.72323216 |
| 26 | ribosome biogenesis (GO:0042254) | 3.71587504 |
| 27 | spliceosomal snRNP assembly (GO:0000387) | 3.70266926 |
| 28 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.67301739 |
| 29 | chromatin remodeling at centromere (GO:0031055) | 3.67125515 |
| 30 | DNA double-strand break processing (GO:0000729) | 3.63428400 |
| 31 | transcription from mitochondrial promoter (GO:0006390) | 3.60444606 |
| 32 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.53505772 |
| 33 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.53505772 |
| 34 | IMP biosynthetic process (GO:0006188) | 3.51526737 |
| 35 | CENP-A containing nucleosome assembly (GO:0034080) | 3.46846342 |
| 36 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.44853751 |
| 37 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.43633328 |
| 38 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.43633328 |
| 39 | isotype switching (GO:0045190) | 3.43633328 |
| 40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.41989914 |
| 41 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.41714667 |
| 42 | DNA replication checkpoint (GO:0000076) | 3.41240449 |
| 43 | histone exchange (GO:0043486) | 3.39850437 |
| 44 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.38420340 |
| 45 | ribosomal small subunit assembly (GO:0000028) | 3.34794643 |
| 46 | protein neddylation (GO:0045116) | 3.34687402 |
| 47 | negative regulation of ligase activity (GO:0051352) | 3.31547718 |
| 48 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.31547718 |
| 49 | ribosomal large subunit biogenesis (GO:0042273) | 3.29664077 |
| 50 | IMP metabolic process (GO:0046040) | 3.29411553 |
| 51 | GTP biosynthetic process (GO:0006183) | 3.29359978 |
| 52 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.25251199 |
| 53 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.21690731 |
| 54 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.20578197 |
| 55 | cellular component biogenesis (GO:0044085) | 3.18086964 |
| 56 | meiotic chromosome segregation (GO:0045132) | 3.16963178 |
| 57 | viral mRNA export from host cell nucleus (GO:0046784) | 3.15677413 |
| 58 | RNA-dependent DNA replication (GO:0006278) | 3.15655885 |
| 59 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.12658290 |
| 60 | formation of translation preinitiation complex (GO:0001731) | 3.10593326 |
| 61 | histone mRNA metabolic process (GO:0008334) | 3.10435419 |
| 62 | ncRNA metabolic process (GO:0034660) | 3.08536006 |
| 63 | translation (GO:0006412) | 3.07095809 |
| 64 | establishment of integrated proviral latency (GO:0075713) | 3.03894788 |
| 65 | termination of RNA polymerase I transcription (GO:0006363) | 3.03161761 |
| 66 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.02974599 |
| 67 | protein targeting to mitochondrion (GO:0006626) | 3.02940206 |
| 68 | respiratory chain complex IV assembly (GO:0008535) | 3.01718102 |
| 69 | ncRNA processing (GO:0034470) | 3.01498387 |
| 70 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.00916542 |
| 71 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.00611391 |
| 72 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.00611391 |
| 73 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.00611391 |
| 74 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.00562741 |
| 75 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.98787533 |
| 76 | regulation of transcription from RNA polymerase I promoter (GO:0006356) | 2.98525497 |
| 77 | protein deneddylation (GO:0000338) | 2.98049605 |
| 78 | ribosomal small subunit biogenesis (GO:0042274) | 2.97981817 |
| 79 | purine nucleobase biosynthetic process (GO:0009113) | 2.96991023 |
| 80 | protein complex biogenesis (GO:0070271) | 2.96984523 |
| 81 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.95498795 |
| 82 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.95498795 |
| 83 | nucleobase biosynthetic process (GO:0046112) | 2.95087241 |
| 84 | UTP biosynthetic process (GO:0006228) | 2.94121002 |
| 85 | establishment of protein localization to mitochondrion (GO:0072655) | 2.92767618 |
| 86 | maturation of SSU-rRNA (GO:0030490) | 2.90710034 |
| 87 | positive regulation of ligase activity (GO:0051351) | 2.90333860 |
| 88 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.90109821 |
| 89 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.90109821 |
| 90 | synapsis (GO:0007129) | 2.89110741 |
| 91 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.88007835 |
| 92 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.87123613 |
| 93 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.84563812 |
| 94 | tRNA processing (GO:0008033) | 2.82839163 |
| 95 | DNA strand elongation (GO:0022616) | 2.81584729 |
| 96 | tRNA metabolic process (GO:0006399) | 2.80778076 |
| 97 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.79931992 |
| 98 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.79931992 |
| 99 | NADH dehydrogenase complex assembly (GO:0010257) | 2.79931992 |
| 100 | DNA-templated transcription, termination (GO:0006353) | 2.77223766 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.08086802 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.38205959 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.37251815 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.22700708 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.76178434 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.36231405 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.30292764 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 3.25526819 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.09688592 |
| 10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.94336085 |
| 11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.81103381 |
| 12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.68104872 |
| 13 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.65081574 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.63066016 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.51133864 |
| 16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.49463491 |
| 17 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.47720421 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.34271849 |
| 19 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.28710064 |
| 20 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.24137615 |
| 21 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.21273264 |
| 22 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.18946802 |
| 23 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.18083422 |
| 24 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.16208967 |
| 25 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.13281272 |
| 26 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.09911055 |
| 27 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.05675938 |
| 28 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.04602361 |
| 29 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.04432567 |
| 30 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.99162286 |
| 31 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.93551566 |
| 32 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.84415704 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.83058918 |
| 34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.75270974 |
| 35 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.74847943 |
| 36 | EWS_26573619_Chip-Seq_HEK293_Human | 1.74723967 |
| 37 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.70419517 |
| 38 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.68264053 |
| 39 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.68142004 |
| 40 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.65030101 |
| 41 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.63441932 |
| 42 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.59228544 |
| 43 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.57923657 |
| 44 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.54770521 |
| 45 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.51098758 |
| 46 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.50447297 |
| 47 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.50053190 |
| 48 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.49983973 |
| 49 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.46844781 |
| 50 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.44631707 |
| 51 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.40954817 |
| 52 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.40925976 |
| 53 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.40319150 |
| 54 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.36161454 |
| 55 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.32331544 |
| 56 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.31760420 |
| 57 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.31176089 |
| 58 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.30145793 |
| 59 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.29841895 |
| 60 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.28187403 |
| 61 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.25044936 |
| 62 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.22621589 |
| 63 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.20616475 |
| 64 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.20227723 |
| 65 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.19065421 |
| 66 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.13851674 |
| 67 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12289947 |
| 68 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.12250358 |
| 69 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.07579963 |
| 70 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.06218519 |
| 71 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.99226717 |
| 72 | FUS_26573619_Chip-Seq_HEK293_Human | 0.99092733 |
| 73 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.98686382 |
| 74 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97522254 |
| 75 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.96949735 |
| 76 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.96949735 |
| 77 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.96101899 |
| 78 | P300_19829295_ChIP-Seq_ESCs_Human | 0.95058658 |
| 79 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.94855111 |
| 80 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.90855885 |
| 81 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.88571560 |
| 82 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.88571560 |
| 83 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.88539806 |
| 84 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.86693727 |
| 85 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.85309233 |
| 86 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.82766253 |
| 87 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.81557299 |
| 88 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.81354569 |
| 89 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.81113168 |
| 90 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.80009320 |
| 91 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.79599677 |
| 92 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.78899864 |
| 93 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.78322210 |
| 94 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.77358417 |
| 95 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.77358417 |
| 96 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.77358417 |
| 97 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.77059040 |
| 98 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.75612935 |
| 99 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.72387019 |
| 100 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.72342766 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 3.84179645 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 3.80986444 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.43015493 |
| 4 | MP0003693_abnormal_embryo_hatching | 3.37323332 |
| 5 | MP0003718_maternal_effect | 3.33827985 |
| 6 | MP0008877_abnormal_DNA_methylation | 3.26924194 |
| 7 | MP0003111_abnormal_nucleus_morphology | 3.15022713 |
| 8 | MP0008058_abnormal_DNA_repair | 3.05549219 |
| 9 | MP0006072_abnormal_retinal_apoptosis | 2.91783030 |
| 10 | MP0002102_abnormal_ear_morphology | 2.69867201 |
| 11 | MP0008872_abnormal_physiological_respon | 2.23031715 |
| 12 | MP0001293_anophthalmia | 2.10616649 |
| 13 | MP0001873_stomach_inflammation | 2.09781265 |
| 14 | MP0008057_abnormal_DNA_replication | 2.04879716 |
| 15 | MP0003077_abnormal_cell_cycle | 2.02673623 |
| 16 | MP0008007_abnormal_cellular_replicative | 2.02548387 |
| 17 | MP0001986_abnormal_taste_sensitivity | 1.95640550 |
| 18 | MP0008932_abnormal_embryonic_tissue | 1.83416754 |
| 19 | MP0003195_calcinosis | 1.83370612 |
| 20 | MP0005084_abnormal_gallbladder_morpholo | 1.79619390 |
| 21 | MP0001485_abnormal_pinna_reflex | 1.76620271 |
| 22 | MP0006035_abnormal_mitochondrial_morpho | 1.76390591 |
| 23 | MP0001529_abnormal_vocalization | 1.72648701 |
| 24 | MP0006036_abnormal_mitochondrial_physio | 1.71166186 |
| 25 | MP0008789_abnormal_olfactory_epithelium | 1.70710560 |
| 26 | MP0003567_abnormal_fetal_cardiomyocyte | 1.69836851 |
| 27 | MP0008875_abnormal_xenobiotic_pharmacok | 1.68288406 |
| 28 | MP0001968_abnormal_touch/_nociception | 1.56446045 |
| 29 | MP0003786_premature_aging | 1.54755041 |
| 30 | MP0002736_abnormal_nociception_after | 1.50505176 |
| 31 | MP0002160_abnormal_reproductive_system | 1.47643656 |
| 32 | MP0005389_reproductive_system_phenotype | 1.46689807 |
| 33 | MP0003119_abnormal_digestive_system | 1.44823129 |
| 34 | MP0002277_abnormal_respiratory_mucosa | 1.44236706 |
| 35 | MP0002138_abnormal_hepatobiliary_system | 1.42371496 |
| 36 | MP0002210_abnormal_sex_determination | 1.40836341 |
| 37 | MP0002163_abnormal_gland_morphology | 1.35069811 |
| 38 | MP0003183_abnormal_peptide_metabolism | 1.33139861 |
| 39 | MP0001984_abnormal_olfaction | 1.32133337 |
| 40 | MP0001929_abnormal_gametogenesis | 1.32068939 |
| 41 | MP0003646_muscle_fatigue | 1.30915326 |
| 42 | MP0003186_abnormal_redox_activity | 1.28829999 |
| 43 | MP0005394_taste/olfaction_phenotype | 1.27226418 |
| 44 | MP0005499_abnormal_olfactory_system | 1.27226418 |
| 45 | MP0005253_abnormal_eye_physiology | 1.22209902 |
| 46 | MP0002254_reproductive_system_inflammat | 1.17963304 |
| 47 | MP0004145_abnormal_muscle_electrophysio | 1.17505877 |
| 48 | MP0000372_irregular_coat_pigmentation | 1.16145981 |
| 49 | MP0005408_hypopigmentation | 1.12021035 |
| 50 | MP0005551_abnormal_eye_electrophysiolog | 1.11860245 |
| 51 | MP0003890_abnormal_embryonic-extraembry | 1.11587197 |
| 52 | MP0001145_abnormal_male_reproductive | 1.11190561 |
| 53 | MP0005379_endocrine/exocrine_gland_phen | 1.09914307 |
| 54 | MP0000653_abnormal_sex_gland | 1.09361029 |
| 55 | MP0001919_abnormal_reproductive_system | 1.05029468 |
| 56 | MP0001697_abnormal_embryo_size | 1.03571552 |
| 57 | MP0001835_abnormal_antigen_presentation | 1.03202452 |
| 58 | MP0001188_hyperpigmentation | 1.03194985 |
| 59 | MP0005410_abnormal_fertilization | 1.00950296 |
| 60 | MP0002938_white_spotting | 1.00776643 |
| 61 | MP0000358_abnormal_cell_content/ | 1.00706970 |
| 62 | MP0005075_abnormal_melanosome_morpholog | 1.00035405 |
| 63 | MP0005645_abnormal_hypothalamus_physiol | 0.99107725 |
| 64 | MP0001730_embryonic_growth_arrest | 0.98236602 |
| 65 | MP0005395_other_phenotype | 0.97325382 |
| 66 | MP0001119_abnormal_female_reproductive | 0.96634644 |
| 67 | MP0009333_abnormal_splenocyte_physiolog | 0.96513264 |
| 68 | MP0005636_abnormal_mineral_homeostasis | 0.93258417 |
| 69 | MP0004742_abnormal_vestibular_system | 0.91930973 |
| 70 | MP0003698_abnormal_male_reproductive | 0.87895663 |
| 71 | MP0001672_abnormal_embryogenesis/_devel | 0.87035620 |
| 72 | MP0005380_embryogenesis_phenotype | 0.87035620 |
| 73 | MP0005647_abnormal_sex_gland | 0.85634808 |
| 74 | MP0000313_abnormal_cell_death | 0.83950860 |
| 75 | MP0003936_abnormal_reproductive_system | 0.83543067 |
| 76 | MP0003787_abnormal_imprinting | 0.82974274 |
| 77 | MP0002876_abnormal_thyroid_physiology | 0.82535884 |
| 78 | MP0002085_abnormal_embryonic_tissue | 0.81564175 |
| 79 | MP0005671_abnormal_response_to | 0.80233846 |
| 80 | MP0003941_abnormal_skin_development | 0.79110357 |
| 81 | MP0000350_abnormal_cell_proliferation | 0.78989772 |
| 82 | MP0009379_abnormal_foot_pigmentation | 0.78393652 |
| 83 | MP0001348_abnormal_lacrimal_gland | 0.78200492 |
| 84 | MP0001286_abnormal_eye_development | 0.76385469 |
| 85 | MP0002088_abnormal_embryonic_growth/wei | 0.75368040 |
| 86 | MP0000490_abnormal_crypts_of | 0.75323781 |
| 87 | MP0002751_abnormal_autonomic_nervous | 0.74885733 |
| 88 | MP0002272_abnormal_nervous_system | 0.74549975 |
| 89 | MP0000566_synostosis | 0.73283088 |
| 90 | MP0003984_embryonic_growth_retardation | 0.71622240 |
| 91 | MP0000631_abnormal_neuroendocrine_gland | 0.70864551 |
| 92 | MP0002084_abnormal_developmental_patter | 0.70373287 |
| 93 | MP0002080_prenatal_lethality | 0.66911654 |
| 94 | MP0004142_abnormal_muscle_tone | 0.65539325 |
| 95 | MP0003137_abnormal_impulse_conducting | 0.65056452 |
| 96 | MP0003011_delayed_dark_adaptation | 0.64920462 |
| 97 | MP0004215_abnormal_myocardial_fiber | 0.64673804 |
| 98 | MP0002161_abnormal_fertility/fecundity | 0.64555506 |
| 99 | MP0002837_dystrophic_cardiac_calcinosis | 0.64340228 |
| 100 | MP0001764_abnormal_homeostasis | 0.63424527 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.80727100 |
| 2 | Increased hepatocellular lipid droplets (HP:0006565) | 3.73259354 |
| 3 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.59753501 |
| 4 | Increased CSF lactate (HP:0002490) | 3.57438677 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.46265477 |
| 6 | Acute encephalopathy (HP:0006846) | 3.43965636 |
| 7 | Abnormality of the labia minora (HP:0012880) | 3.33761133 |
| 8 | Lipid accumulation in hepatocytes (HP:0006561) | 3.32775412 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.27557337 |
| 10 | Stomatitis (HP:0010280) | 3.09829642 |
| 11 | Progressive macrocephaly (HP:0004481) | 3.05272125 |
| 12 | Dyschromatopsia (HP:0007641) | 3.03442796 |
| 13 | Hyperglycinemia (HP:0002154) | 3.00507520 |
| 14 | Hyperglycinuria (HP:0003108) | 2.98336185 |
| 15 | Renal Fanconi syndrome (HP:0001994) | 2.91482838 |
| 16 | Increased serum lactate (HP:0002151) | 2.88428342 |
| 17 | Type II lissencephaly (HP:0007260) | 2.76305496 |
| 18 | Hepatocellular necrosis (HP:0001404) | 2.75646341 |
| 19 | Abolished electroretinogram (ERG) (HP:0000550) | 2.71231512 |
| 20 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.68824259 |
| 21 | Abnormality of alanine metabolism (HP:0010916) | 2.68824259 |
| 22 | Hyperalaninemia (HP:0003348) | 2.68824259 |
| 23 | Cerebral edema (HP:0002181) | 2.65934625 |
| 24 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.62444914 |
| 25 | Horseshoe kidney (HP:0000085) | 2.61755037 |
| 26 | Pendular nystagmus (HP:0012043) | 2.60882361 |
| 27 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.60525281 |
| 28 | Abnormality of serum amino acid levels (HP:0003112) | 2.49722985 |
| 29 | Pancreatic cysts (HP:0001737) | 2.48772838 |
| 30 | Abnormality of glycine metabolism (HP:0010895) | 2.46568035 |
| 31 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.46568035 |
| 32 | Septo-optic dysplasia (HP:0100842) | 2.45941358 |
| 33 | Hypomagnesemia (HP:0002917) | 2.45740991 |
| 34 | Exertional dyspnea (HP:0002875) | 2.43312942 |
| 35 | Congenital, generalized hypertrichosis (HP:0004540) | 2.42574638 |
| 36 | Abnormality of midbrain morphology (HP:0002418) | 2.42459739 |
| 37 | Molar tooth sign on MRI (HP:0002419) | 2.42459739 |
| 38 | Meckel diverticulum (HP:0002245) | 2.40020246 |
| 39 | Multiple enchondromatosis (HP:0005701) | 2.39184994 |
| 40 | Abnormality of the ileum (HP:0001549) | 2.38784459 |
| 41 | Hepatic necrosis (HP:0002605) | 2.36021490 |
| 42 | Methylmalonic acidemia (HP:0002912) | 2.35972441 |
| 43 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.35372865 |
| 44 | Abnormality of methionine metabolism (HP:0010901) | 2.32676298 |
| 45 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.32348362 |
| 46 | Lactic acidosis (HP:0003128) | 2.30695261 |
| 47 | Carpal bone hypoplasia (HP:0001498) | 2.26222170 |
| 48 | Optic disc pallor (HP:0000543) | 2.25370009 |
| 49 | Supernumerary spleens (HP:0009799) | 2.24532512 |
| 50 | 3-Methylglutaconic aciduria (HP:0003535) | 2.23532559 |
| 51 | Abnormal biliary tract physiology (HP:0012439) | 2.22967633 |
| 52 | Bile duct proliferation (HP:0001408) | 2.22967633 |
| 53 | Pancytopenia (HP:0001876) | 2.22070081 |
| 54 | Cerebellar dysplasia (HP:0007033) | 2.22024182 |
| 55 | Poor head control (HP:0002421) | 2.21542865 |
| 56 | Methylmalonic aciduria (HP:0012120) | 2.21427475 |
| 57 | Respiratory difficulties (HP:0002880) | 2.20065670 |
| 58 | Increased serum pyruvate (HP:0003542) | 2.19620926 |
| 59 | Abnormality of magnesium homeostasis (HP:0004921) | 2.19411967 |
| 60 | Rib fusion (HP:0000902) | 2.17215850 |
| 61 | Colon cancer (HP:0003003) | 2.15932692 |
| 62 | Aplastic anemia (HP:0001915) | 2.13701063 |
| 63 | Degeneration of anterior horn cells (HP:0002398) | 2.13349990 |
| 64 | Abnormality of the anterior horn cell (HP:0006802) | 2.13349990 |
| 65 | Pancreatic fibrosis (HP:0100732) | 2.12207769 |
| 66 | Leukodystrophy (HP:0002415) | 2.10492286 |
| 67 | IgG deficiency (HP:0004315) | 2.10106417 |
| 68 | Bilateral microphthalmos (HP:0007633) | 2.08216375 |
| 69 | Macrocytic anemia (HP:0001972) | 2.07532571 |
| 70 | Abnormality of the pons (HP:0007361) | 2.06699652 |
| 71 | Increased intramyocellular lipid droplets (HP:0012240) | 2.05675450 |
| 72 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.03673922 |
| 73 | Vitreoretinal degeneration (HP:0000655) | 2.02294368 |
| 74 | Oral leukoplakia (HP:0002745) | 2.00967936 |
| 75 | Ependymoma (HP:0002888) | 2.00544768 |
| 76 | Lethargy (HP:0001254) | 2.00320601 |
| 77 | Abnormal lung lobation (HP:0002101) | 1.96881334 |
| 78 | Congenital stationary night blindness (HP:0007642) | 1.96284703 |
| 79 | Abnormality of the preputium (HP:0100587) | 1.96166045 |
| 80 | Testicular atrophy (HP:0000029) | 1.93924456 |
| 81 | Hypoplasia of the pons (HP:0012110) | 1.93238977 |
| 82 | Ectopic kidney (HP:0000086) | 1.93172921 |
| 83 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.90967476 |
| 84 | Respiratory failure (HP:0002878) | 1.89109698 |
| 85 | Megaloblastic anemia (HP:0001889) | 1.88514270 |
| 86 | Posterior subcapsular cataract (HP:0007787) | 1.84464513 |
| 87 | Nephronophthisis (HP:0000090) | 1.83952206 |
| 88 | Absent septum pellucidum (HP:0001331) | 1.81771771 |
| 89 | Pigmentary retinal degeneration (HP:0001146) | 1.81504362 |
| 90 | Polydipsia (HP:0001959) | 1.81453561 |
| 91 | Abnormal drinking behavior (HP:0030082) | 1.81453561 |
| 92 | Cellular immunodeficiency (HP:0005374) | 1.81393815 |
| 93 | Patent foramen ovale (HP:0001655) | 1.80548480 |
| 94 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.78575686 |
| 95 | Abnormality of urine glucose concentration (HP:0011016) | 1.76234077 |
| 96 | Glycosuria (HP:0003076) | 1.76234077 |
| 97 | Abnormality of chromosome stability (HP:0003220) | 1.74930100 |
| 98 | Tetany (HP:0001281) | 1.74927636 |
| 99 | Abnormal number of incisors (HP:0011064) | 1.73633678 |
| 100 | Adrenal hypoplasia (HP:0000835) | 1.72524808 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | WNK3 | 3.66281687 |
| 2 | BUB1 | 3.61729455 |
| 3 | MKNK2 | 3.44856220 |
| 4 | TSSK6 | 3.39636420 |
| 5 | EIF2AK1 | 2.97068129 |
| 6 | PLK4 | 2.94644596 |
| 7 | EIF2AK3 | 2.93629314 |
| 8 | SRPK1 | 2.84559427 |
| 9 | MKNK1 | 2.79769798 |
| 10 | PBK | 2.73266339 |
| 11 | VRK2 | 2.55335136 |
| 12 | MST4 | 2.51770797 |
| 13 | NUAK1 | 2.50635871 |
| 14 | ZAK | 2.44680022 |
| 15 | WNK4 | 2.41636671 |
| 16 | CDC7 | 2.37559321 |
| 17 | PLK3 | 2.20733071 |
| 18 | TNIK | 1.93618442 |
| 19 | STK16 | 1.89143482 |
| 20 | STK39 | 1.88926732 |
| 21 | TTK | 1.86551821 |
| 22 | ADRBK2 | 1.85398578 |
| 23 | ALK | 1.57332775 |
| 24 | TXK | 1.57224759 |
| 25 | OXSR1 | 1.53917412 |
| 26 | BMPR1B | 1.52287318 |
| 27 | NEK1 | 1.45646337 |
| 28 | VRK1 | 1.44462890 |
| 29 | TRIM28 | 1.43793632 |
| 30 | TLK1 | 1.41454844 |
| 31 | NME1 | 1.39662117 |
| 32 | NEK2 | 1.25951135 |
| 33 | GRK1 | 1.25852823 |
| 34 | PLK1 | 1.12759258 |
| 35 | EIF2AK2 | 1.08955162 |
| 36 | RPS6KA4 | 0.99469186 |
| 37 | PNCK | 0.99421320 |
| 38 | CDK8 | 0.93076010 |
| 39 | PASK | 0.92748048 |
| 40 | ACVR1B | 0.92699191 |
| 41 | FRK | 0.85674828 |
| 42 | STK38L | 0.80435065 |
| 43 | CHEK2 | 0.78674795 |
| 44 | ATR | 0.76059653 |
| 45 | STK3 | 0.75679875 |
| 46 | STK4 | 0.72863579 |
| 47 | TAF1 | 0.68252619 |
| 48 | NME2 | 0.68068877 |
| 49 | CLK1 | 0.66805727 |
| 50 | PLK2 | 0.66781351 |
| 51 | BCKDK | 0.66707497 |
| 52 | SCYL2 | 0.62139792 |
| 53 | CHEK1 | 0.61557086 |
| 54 | AURKB | 0.61353252 |
| 55 | IRAK4 | 0.61198306 |
| 56 | DYRK2 | 0.60317832 |
| 57 | TGFBR1 | 0.59312267 |
| 58 | WEE1 | 0.57423131 |
| 59 | MAP3K9 | 0.57127994 |
| 60 | CSNK2A2 | 0.56910210 |
| 61 | DAPK2 | 0.55591906 |
| 62 | CSNK1G1 | 0.54477375 |
| 63 | BRD4 | 0.50994680 |
| 64 | NLK | 0.50955778 |
| 65 | CSNK2A1 | 0.50018252 |
| 66 | PDK2 | 0.49729997 |
| 67 | DAPK1 | 0.47434094 |
| 68 | PAK6 | 0.47355621 |
| 69 | RPS6KA5 | 0.46465334 |
| 70 | WNK1 | 0.46191522 |
| 71 | INSRR | 0.45891111 |
| 72 | TEC | 0.44993413 |
| 73 | CSNK1E | 0.44910153 |
| 74 | STK10 | 0.44450747 |
| 75 | FGFR1 | 0.44265437 |
| 76 | TAOK3 | 0.42262373 |
| 77 | MAP4K2 | 0.41942547 |
| 78 | ATM | 0.41247149 |
| 79 | PRKCG | 0.38471462 |
| 80 | CSNK1G3 | 0.37517731 |
| 81 | CSNK1D | 0.36247306 |
| 82 | BRSK2 | 0.36180482 |
| 83 | TIE1 | 0.34978043 |
| 84 | CSNK1G2 | 0.34469043 |
| 85 | MAP3K12 | 0.34169500 |
| 86 | PHKG2 | 0.33494065 |
| 87 | PHKG1 | 0.33494065 |
| 88 | ERBB3 | 0.33347315 |
| 89 | LRRK2 | 0.31476704 |
| 90 | CDK19 | 0.30742494 |
| 91 | MAP3K13 | 0.28878802 |
| 92 | AURKA | 0.28133330 |
| 93 | CDK7 | 0.27048415 |
| 94 | ADRBK1 | 0.26596387 |
| 95 | MATK | 0.25579428 |
| 96 | PRKCE | 0.24644144 |
| 97 | PRKDC | 0.24194609 |
| 98 | BRAF | 0.23934056 |
| 99 | PRKD3 | 0.23828287 |
| 100 | TYRO3 | 0.23084169 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.61577754 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.61914661 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.24524204 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.07747379 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.98618651 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.82255608 |
| 7 | RNA transport_Homo sapiens_hsa03013 | 2.67121665 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.62767847 |
| 9 | RNA degradation_Homo sapiens_hsa03018 | 2.53548061 |
| 10 | Protein export_Homo sapiens_hsa03060 | 2.51416341 |
| 11 | Spliceosome_Homo sapiens_hsa03040 | 2.39781303 |
| 12 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.34532255 |
| 13 | Parkinsons disease_Homo sapiens_hsa05012 | 2.28706617 |
| 14 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.28562157 |
| 15 | Homologous recombination_Homo sapiens_hsa03440 | 2.18417792 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.13165992 |
| 17 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.79755532 |
| 18 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.74275677 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.74241519 |
| 20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.72731294 |
| 21 | Huntingtons disease_Homo sapiens_hsa05016 | 1.63479828 |
| 22 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.60657933 |
| 23 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.57662185 |
| 24 | Base excision repair_Homo sapiens_hsa03410 | 1.57631976 |
| 25 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.51572158 |
| 26 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.49147669 |
| 27 | Asthma_Homo sapiens_hsa05310 | 1.37432558 |
| 28 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.34410067 |
| 29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.31387449 |
| 30 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.27553369 |
| 31 | Alzheimers disease_Homo sapiens_hsa05010 | 1.22845084 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.22813132 |
| 33 | Allograft rejection_Homo sapiens_hsa05330 | 1.20811444 |
| 34 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.18779815 |
| 35 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.18720523 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.16466579 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.15827102 |
| 38 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.05369791 |
| 39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.04798591 |
| 40 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.03474501 |
| 41 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.02297952 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.00448636 |
| 43 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.99904199 |
| 44 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.95576774 |
| 45 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.92185121 |
| 46 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.90054307 |
| 47 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.88698714 |
| 48 | Cell cycle_Homo sapiens_hsa04110 | 0.85358850 |
| 49 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.82282363 |
| 50 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.81272852 |
| 51 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.79924719 |
| 52 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.78809188 |
| 53 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.78151420 |
| 54 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.71286853 |
| 55 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.69555474 |
| 56 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.67126741 |
| 57 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.65777722 |
| 58 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.64179804 |
| 59 | Metabolic pathways_Homo sapiens_hsa01100 | 0.64064816 |
| 60 | Peroxisome_Homo sapiens_hsa04146 | 0.63322359 |
| 61 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.60497081 |
| 62 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.56338958 |
| 63 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.55513669 |
| 64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.55363809 |
| 65 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.54766959 |
| 66 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.53503505 |
| 67 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.52792936 |
| 68 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.52162931 |
| 69 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.51648037 |
| 70 | Phototransduction_Homo sapiens_hsa04744 | 0.51172260 |
| 71 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.51101143 |
| 72 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.51024402 |
| 73 | Carbon metabolism_Homo sapiens_hsa01200 | 0.50932799 |
| 74 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.49441292 |
| 75 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.45202504 |
| 76 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.43130096 |
| 77 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.40946630 |
| 78 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.40904421 |
| 79 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.39352003 |
| 80 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.37327090 |
| 81 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.37326706 |
| 82 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.37093170 |
| 83 | Retinol metabolism_Homo sapiens_hsa00830 | 0.36887621 |
| 84 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.36738885 |
| 85 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.35933058 |
| 86 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.35655602 |
| 87 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.33848925 |
| 88 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.31903315 |
| 89 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.30874079 |
| 90 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.29954488 |
| 91 | Nicotine addiction_Homo sapiens_hsa05033 | 0.29459438 |
| 92 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.25527431 |
| 93 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.25210426 |
| 94 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.25124046 |
| 95 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.24865970 |
| 96 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.24195911 |
| 97 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.19843972 |
| 98 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.19150948 |
| 99 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.18878519 |
| 100 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.17927556 |

