NPM1P38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.40597893
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.11303202
3rRNA modification (GO:0000154)4.99667890
4chaperone-mediated protein transport (GO:0072321)4.92071586
5rRNA methylation (GO:0031167)4.48463228
6ribosome assembly (GO:0042255)4.48454837
7exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.38303087
8DNA deamination (GO:0045006)4.37995067
9nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.32937223
10maturation of 5.8S rRNA (GO:0000460)4.18018824
11telomere maintenance via telomerase (GO:0007004)4.12916877
12pseudouridine synthesis (GO:0001522)4.04381302
13water-soluble vitamin biosynthetic process (GO:0042364)3.98152965
14termination of RNA polymerase III transcription (GO:0006386)3.94955831
15transcription elongation from RNA polymerase III promoter (GO:0006385)3.94955831
16spliceosomal complex assembly (GO:0000245)3.93532814
17DNA replication-dependent nucleosome assembly (GO:0006335)3.87407398
18DNA replication-dependent nucleosome organization (GO:0034723)3.87407398
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85889655
20rRNA processing (GO:0006364)3.82426176
21regulation of centriole replication (GO:0046599)3.76130091
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75283945
23ATP synthesis coupled proton transport (GO:0015986)3.75283945
24mitochondrial RNA metabolic process (GO:0000959)3.74609069
25rRNA metabolic process (GO:0016072)3.72323216
26ribosome biogenesis (GO:0042254)3.71587504
27spliceosomal snRNP assembly (GO:0000387)3.70266926
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67301739
29chromatin remodeling at centromere (GO:0031055)3.67125515
30DNA double-strand break processing (GO:0000729)3.63428400
31transcription from mitochondrial promoter (GO:0006390)3.60444606
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.53505772
33regulation of mitotic spindle checkpoint (GO:1903504)3.53505772
34IMP biosynthetic process (GO:0006188)3.51526737
35CENP-A containing nucleosome assembly (GO:0034080)3.46846342
36ribonucleoprotein complex biogenesis (GO:0022613)3.44853751
37somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.43633328
38somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.43633328
39isotype switching (GO:0045190)3.43633328
40regulation of cellular amino acid metabolic process (GO:0006521)3.41989914
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.41714667
42DNA replication checkpoint (GO:0000076)3.41240449
43histone exchange (GO:0043486)3.39850437
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.38420340
45ribosomal small subunit assembly (GO:0000028)3.34794643
46protein neddylation (GO:0045116)3.34687402
47negative regulation of ligase activity (GO:0051352)3.31547718
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31547718
49ribosomal large subunit biogenesis (GO:0042273)3.29664077
50IMP metabolic process (GO:0046040)3.29411553
51GTP biosynthetic process (GO:0006183)3.29359978
52RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.25251199
53mitochondrial respiratory chain complex assembly (GO:0033108)3.21690731
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20578197
55cellular component biogenesis (GO:0044085)3.18086964
56meiotic chromosome segregation (GO:0045132)3.16963178
57viral mRNA export from host cell nucleus (GO:0046784)3.15677413
58RNA-dependent DNA replication (GO:0006278)3.15655885
59DNA catabolic process, exonucleolytic (GO:0000738)3.12658290
60formation of translation preinitiation complex (GO:0001731)3.10593326
61histone mRNA metabolic process (GO:0008334)3.10435419
62ncRNA metabolic process (GO:0034660)3.08536006
63translation (GO:0006412)3.07095809
64establishment of integrated proviral latency (GO:0075713)3.03894788
65termination of RNA polymerase I transcription (GO:0006363)3.03161761
66telomere maintenance via semi-conservative replication (GO:0032201)3.02974599
67protein targeting to mitochondrion (GO:0006626)3.02940206
68respiratory chain complex IV assembly (GO:0008535)3.01718102
69ncRNA processing (GO:0034470)3.01498387
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.00916542
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00611391
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00611391
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00611391
74DNA strand elongation involved in DNA replication (GO:0006271)3.00562741
75positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98787533
76regulation of transcription from RNA polymerase I promoter (GO:0006356)2.98525497
77protein deneddylation (GO:0000338)2.98049605
78ribosomal small subunit biogenesis (GO:0042274)2.97981817
79purine nucleobase biosynthetic process (GO:0009113)2.96991023
80protein complex biogenesis (GO:0070271)2.96984523
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95498795
82signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95498795
83nucleobase biosynthetic process (GO:0046112)2.95087241
84UTP biosynthetic process (GO:0006228)2.94121002
85establishment of protein localization to mitochondrion (GO:0072655)2.92767618
86maturation of SSU-rRNA (GO:0030490)2.90710034
87positive regulation of ligase activity (GO:0051351)2.90333860
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.90109821
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90109821
90synapsis (GO:0007129)2.89110741
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88007835
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.87123613
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.84563812
94tRNA processing (GO:0008033)2.82839163
95DNA strand elongation (GO:0022616)2.81584729
96tRNA metabolic process (GO:0006399)2.80778076
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.79931992
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.79931992
99NADH dehydrogenase complex assembly (GO:0010257)2.79931992
100DNA-templated transcription, termination (GO:0006353)2.77223766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.08086802
2E2F7_22180533_ChIP-Seq_HELA_Human4.38205959
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.37251815
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.22700708
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.76178434
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36231405
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30292764
8VDR_22108803_ChIP-Seq_LS180_Human3.25526819
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.09688592
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.94336085
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81103381
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68104872
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.65081574
14VDR_23849224_ChIP-Seq_CD4+_Human2.63066016
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51133864
16ELK1_19687146_ChIP-ChIP_HELA_Human2.49463491
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47720421
18FOXP3_21729870_ChIP-Seq_TREG_Human2.34271849
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28710064
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24137615
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21273264
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18946802
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18083422
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16208967
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13281272
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09911055
27TTF2_22483619_ChIP-Seq_HELA_Human2.05675938
28PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04602361
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04432567
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.99162286
31ZNF274_21170338_ChIP-Seq_K562_Hela1.93551566
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.84415704
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83058918
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.75270974
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74847943
36EWS_26573619_Chip-Seq_HEK293_Human1.74723967
37DCP1A_22483619_ChIP-Seq_HELA_Human1.70419517
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.68264053
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68142004
40GABP_19822575_ChIP-Seq_HepG2_Human1.65030101
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63441932
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59228544
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57923657
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54770521
45XRN2_22483619_ChIP-Seq_HELA_Human1.51098758
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50447297
47EZH2_22144423_ChIP-Seq_EOC_Human1.50053190
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49983973
49MYC_18940864_ChIP-ChIP_HL60_Human1.46844781
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44631707
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.40954817
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40925976
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40319150
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36161454
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32331544
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31760420
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.31176089
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30145793
59AR_21909140_ChIP-Seq_LNCAP_Human1.29841895
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28187403
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.25044936
62TP53_22573176_ChIP-Seq_HFKS_Human1.22621589
63IRF1_19129219_ChIP-ChIP_H3396_Human1.20616475
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20227723
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19065421
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.13851674
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12289947
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12250358
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07579963
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.06218519
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99226717
72FUS_26573619_Chip-Seq_HEK293_Human0.99092733
73POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98686382
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97522254
75FOXA1_25329375_ChIP-Seq_VCAP_Human0.96949735
76FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96949735
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96101899
78P300_19829295_ChIP-Seq_ESCs_Human0.95058658
79NANOG_16153702_ChIP-ChIP_HESCs_Human0.94855111
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90855885
81SOX2_19829295_ChIP-Seq_ESCs_Human0.88571560
82NANOG_19829295_ChIP-Seq_ESCs_Human0.88571560
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.88539806
84KDM5A_27292631_Chip-Seq_BREAST_Human0.86693727
85LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85309233
86NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82766253
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.81557299
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81354569
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81113168
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80009320
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79599677
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.78899864
93RBPJ_21746931_ChIP-Seq_IB4_Human0.78322210
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77358417
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77358417
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77358417
97IGF1R_20145208_ChIP-Seq_DFB_Human0.77059040
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75612935
99ELF5_23300383_ChIP-Seq_T47D_Human0.72387019
100CBP_20019798_ChIP-Seq_JUKART_Human0.72342766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.84179645
2MP0004957_abnormal_blastocyst_morpholog3.80986444
3MP0010094_abnormal_chromosome_stability3.43015493
4MP0003693_abnormal_embryo_hatching3.37323332
5MP0003718_maternal_effect3.33827985
6MP0008877_abnormal_DNA_methylation3.26924194
7MP0003111_abnormal_nucleus_morphology3.15022713
8MP0008058_abnormal_DNA_repair3.05549219
9MP0006072_abnormal_retinal_apoptosis2.91783030
10MP0002102_abnormal_ear_morphology2.69867201
11MP0008872_abnormal_physiological_respon2.23031715
12MP0001293_anophthalmia2.10616649
13MP0001873_stomach_inflammation2.09781265
14MP0008057_abnormal_DNA_replication2.04879716
15MP0003077_abnormal_cell_cycle2.02673623
16MP0008007_abnormal_cellular_replicative2.02548387
17MP0001986_abnormal_taste_sensitivity1.95640550
18MP0008932_abnormal_embryonic_tissue1.83416754
19MP0003195_calcinosis1.83370612
20MP0005084_abnormal_gallbladder_morpholo1.79619390
21MP0001485_abnormal_pinna_reflex1.76620271
22MP0006035_abnormal_mitochondrial_morpho1.76390591
23MP0001529_abnormal_vocalization1.72648701
24MP0006036_abnormal_mitochondrial_physio1.71166186
25MP0008789_abnormal_olfactory_epithelium1.70710560
26MP0003567_abnormal_fetal_cardiomyocyte1.69836851
27MP0008875_abnormal_xenobiotic_pharmacok1.68288406
28MP0001968_abnormal_touch/_nociception1.56446045
29MP0003786_premature_aging1.54755041
30MP0002736_abnormal_nociception_after1.50505176
31MP0002160_abnormal_reproductive_system1.47643656
32MP0005389_reproductive_system_phenotype1.46689807
33MP0003119_abnormal_digestive_system1.44823129
34MP0002277_abnormal_respiratory_mucosa1.44236706
35MP0002138_abnormal_hepatobiliary_system1.42371496
36MP0002210_abnormal_sex_determination1.40836341
37MP0002163_abnormal_gland_morphology1.35069811
38MP0003183_abnormal_peptide_metabolism1.33139861
39MP0001984_abnormal_olfaction1.32133337
40MP0001929_abnormal_gametogenesis1.32068939
41MP0003646_muscle_fatigue1.30915326
42MP0003186_abnormal_redox_activity1.28829999
43MP0005394_taste/olfaction_phenotype1.27226418
44MP0005499_abnormal_olfactory_system1.27226418
45MP0005253_abnormal_eye_physiology1.22209902
46MP0002254_reproductive_system_inflammat1.17963304
47MP0004145_abnormal_muscle_electrophysio1.17505877
48MP0000372_irregular_coat_pigmentation1.16145981
49MP0005408_hypopigmentation1.12021035
50MP0005551_abnormal_eye_electrophysiolog1.11860245
51MP0003890_abnormal_embryonic-extraembry1.11587197
52MP0001145_abnormal_male_reproductive1.11190561
53MP0005379_endocrine/exocrine_gland_phen1.09914307
54MP0000653_abnormal_sex_gland1.09361029
55MP0001919_abnormal_reproductive_system1.05029468
56MP0001697_abnormal_embryo_size1.03571552
57MP0001835_abnormal_antigen_presentation1.03202452
58MP0001188_hyperpigmentation1.03194985
59MP0005410_abnormal_fertilization1.00950296
60MP0002938_white_spotting1.00776643
61MP0000358_abnormal_cell_content/1.00706970
62MP0005075_abnormal_melanosome_morpholog1.00035405
63MP0005645_abnormal_hypothalamus_physiol0.99107725
64MP0001730_embryonic_growth_arrest0.98236602
65MP0005395_other_phenotype0.97325382
66MP0001119_abnormal_female_reproductive0.96634644
67MP0009333_abnormal_splenocyte_physiolog0.96513264
68MP0005636_abnormal_mineral_homeostasis0.93258417
69MP0004742_abnormal_vestibular_system0.91930973
70MP0003698_abnormal_male_reproductive0.87895663
71MP0001672_abnormal_embryogenesis/_devel0.87035620
72MP0005380_embryogenesis_phenotype0.87035620
73MP0005647_abnormal_sex_gland0.85634808
74MP0000313_abnormal_cell_death0.83950860
75MP0003936_abnormal_reproductive_system0.83543067
76MP0003787_abnormal_imprinting0.82974274
77MP0002876_abnormal_thyroid_physiology0.82535884
78MP0002085_abnormal_embryonic_tissue0.81564175
79MP0005671_abnormal_response_to0.80233846
80MP0003941_abnormal_skin_development0.79110357
81MP0000350_abnormal_cell_proliferation0.78989772
82MP0009379_abnormal_foot_pigmentation0.78393652
83MP0001348_abnormal_lacrimal_gland0.78200492
84MP0001286_abnormal_eye_development0.76385469
85MP0002088_abnormal_embryonic_growth/wei0.75368040
86MP0000490_abnormal_crypts_of0.75323781
87MP0002751_abnormal_autonomic_nervous0.74885733
88MP0002272_abnormal_nervous_system0.74549975
89MP0000566_synostosis0.73283088
90MP0003984_embryonic_growth_retardation0.71622240
91MP0000631_abnormal_neuroendocrine_gland0.70864551
92MP0002084_abnormal_developmental_patter0.70373287
93MP0002080_prenatal_lethality0.66911654
94MP0004142_abnormal_muscle_tone0.65539325
95MP0003137_abnormal_impulse_conducting0.65056452
96MP0003011_delayed_dark_adaptation0.64920462
97MP0004215_abnormal_myocardial_fiber0.64673804
98MP0002161_abnormal_fertility/fecundity0.64555506
99MP0002837_dystrophic_cardiac_calcinosis0.64340228
100MP0001764_abnormal_homeostasis0.63424527

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.80727100
2Increased hepatocellular lipid droplets (HP:0006565)3.73259354
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.59753501
4Increased CSF lactate (HP:0002490)3.57438677
5Mitochondrial inheritance (HP:0001427)3.46265477
6Acute encephalopathy (HP:0006846)3.43965636
7Abnormality of the labia minora (HP:0012880)3.33761133
8Lipid accumulation in hepatocytes (HP:0006561)3.32775412
9Abnormal mitochondria in muscle tissue (HP:0008316)3.27557337
10Stomatitis (HP:0010280)3.09829642
11Progressive macrocephaly (HP:0004481)3.05272125
12Dyschromatopsia (HP:0007641)3.03442796
13Hyperglycinemia (HP:0002154)3.00507520
14Hyperglycinuria (HP:0003108)2.98336185
15Renal Fanconi syndrome (HP:0001994)2.91482838
16Increased serum lactate (HP:0002151)2.88428342
17Type II lissencephaly (HP:0007260)2.76305496
18Hepatocellular necrosis (HP:0001404)2.75646341
19Abolished electroretinogram (ERG) (HP:0000550)2.71231512
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68824259
21Abnormality of alanine metabolism (HP:0010916)2.68824259
22Hyperalaninemia (HP:0003348)2.68824259
23Cerebral edema (HP:0002181)2.65934625
24Abnormal rod and cone electroretinograms (HP:0008323)2.62444914
25Horseshoe kidney (HP:0000085)2.61755037
26Pendular nystagmus (HP:0012043)2.60882361
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60525281
28Abnormality of serum amino acid levels (HP:0003112)2.49722985
29Pancreatic cysts (HP:0001737)2.48772838
30Abnormality of glycine metabolism (HP:0010895)2.46568035
31Abnormality of serine family amino acid metabolism (HP:0010894)2.46568035
32Septo-optic dysplasia (HP:0100842)2.45941358
33Hypomagnesemia (HP:0002917)2.45740991
34Exertional dyspnea (HP:0002875)2.43312942
35Congenital, generalized hypertrichosis (HP:0004540)2.42574638
36Abnormality of midbrain morphology (HP:0002418)2.42459739
37Molar tooth sign on MRI (HP:0002419)2.42459739
38Meckel diverticulum (HP:0002245)2.40020246
39Multiple enchondromatosis (HP:0005701)2.39184994
40Abnormality of the ileum (HP:0001549)2.38784459
41Hepatic necrosis (HP:0002605)2.36021490
42Methylmalonic acidemia (HP:0002912)2.35972441
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.35372865
44Abnormality of methionine metabolism (HP:0010901)2.32676298
45Aplasia/hypoplasia of the uterus (HP:0008684)2.32348362
46Lactic acidosis (HP:0003128)2.30695261
47Carpal bone hypoplasia (HP:0001498)2.26222170
48Optic disc pallor (HP:0000543)2.25370009
49Supernumerary spleens (HP:0009799)2.24532512
503-Methylglutaconic aciduria (HP:0003535)2.23532559
51Abnormal biliary tract physiology (HP:0012439)2.22967633
52Bile duct proliferation (HP:0001408)2.22967633
53Pancytopenia (HP:0001876)2.22070081
54Cerebellar dysplasia (HP:0007033)2.22024182
55Poor head control (HP:0002421)2.21542865
56Methylmalonic aciduria (HP:0012120)2.21427475
57Respiratory difficulties (HP:0002880)2.20065670
58Increased serum pyruvate (HP:0003542)2.19620926
59Abnormality of magnesium homeostasis (HP:0004921)2.19411967
60Rib fusion (HP:0000902)2.17215850
61Colon cancer (HP:0003003)2.15932692
62Aplastic anemia (HP:0001915)2.13701063
63Degeneration of anterior horn cells (HP:0002398)2.13349990
64Abnormality of the anterior horn cell (HP:0006802)2.13349990
65Pancreatic fibrosis (HP:0100732)2.12207769
66Leukodystrophy (HP:0002415)2.10492286
67IgG deficiency (HP:0004315)2.10106417
68Bilateral microphthalmos (HP:0007633)2.08216375
69Macrocytic anemia (HP:0001972)2.07532571
70Abnormality of the pons (HP:0007361)2.06699652
71Increased intramyocellular lipid droplets (HP:0012240)2.05675450
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.03673922
73Vitreoretinal degeneration (HP:0000655)2.02294368
74Oral leukoplakia (HP:0002745)2.00967936
75Ependymoma (HP:0002888)2.00544768
76Lethargy (HP:0001254)2.00320601
77Abnormal lung lobation (HP:0002101)1.96881334
78Congenital stationary night blindness (HP:0007642)1.96284703
79Abnormality of the preputium (HP:0100587)1.96166045
80Testicular atrophy (HP:0000029)1.93924456
81Hypoplasia of the pons (HP:0012110)1.93238977
82Ectopic kidney (HP:0000086)1.93172921
83Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90967476
84Respiratory failure (HP:0002878)1.89109698
85Megaloblastic anemia (HP:0001889)1.88514270
86Posterior subcapsular cataract (HP:0007787)1.84464513
87Nephronophthisis (HP:0000090)1.83952206
88Absent septum pellucidum (HP:0001331)1.81771771
89Pigmentary retinal degeneration (HP:0001146)1.81504362
90Polydipsia (HP:0001959)1.81453561
91Abnormal drinking behavior (HP:0030082)1.81453561
92Cellular immunodeficiency (HP:0005374)1.81393815
93Patent foramen ovale (HP:0001655)1.80548480
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78575686
95Abnormality of urine glucose concentration (HP:0011016)1.76234077
96Glycosuria (HP:0003076)1.76234077
97Abnormality of chromosome stability (HP:0003220)1.74930100
98Tetany (HP:0001281)1.74927636
99Abnormal number of incisors (HP:0011064)1.73633678
100Adrenal hypoplasia (HP:0000835)1.72524808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.66281687
2BUB13.61729455
3MKNK23.44856220
4TSSK63.39636420
5EIF2AK12.97068129
6PLK42.94644596
7EIF2AK32.93629314
8SRPK12.84559427
9MKNK12.79769798
10PBK2.73266339
11VRK22.55335136
12MST42.51770797
13NUAK12.50635871
14ZAK2.44680022
15WNK42.41636671
16CDC72.37559321
17PLK32.20733071
18TNIK1.93618442
19STK161.89143482
20STK391.88926732
21TTK1.86551821
22ADRBK21.85398578
23ALK1.57332775
24TXK1.57224759
25OXSR11.53917412
26BMPR1B1.52287318
27NEK11.45646337
28VRK11.44462890
29TRIM281.43793632
30TLK11.41454844
31NME11.39662117
32NEK21.25951135
33GRK11.25852823
34PLK11.12759258
35EIF2AK21.08955162
36RPS6KA40.99469186
37PNCK0.99421320
38CDK80.93076010
39PASK0.92748048
40ACVR1B0.92699191
41FRK0.85674828
42STK38L0.80435065
43CHEK20.78674795
44ATR0.76059653
45STK30.75679875
46STK40.72863579
47TAF10.68252619
48NME20.68068877
49CLK10.66805727
50PLK20.66781351
51BCKDK0.66707497
52SCYL20.62139792
53CHEK10.61557086
54AURKB0.61353252
55IRAK40.61198306
56DYRK20.60317832
57TGFBR10.59312267
58WEE10.57423131
59MAP3K90.57127994
60CSNK2A20.56910210
61DAPK20.55591906
62CSNK1G10.54477375
63BRD40.50994680
64NLK0.50955778
65CSNK2A10.50018252
66PDK20.49729997
67DAPK10.47434094
68PAK60.47355621
69RPS6KA50.46465334
70WNK10.46191522
71INSRR0.45891111
72TEC0.44993413
73CSNK1E0.44910153
74STK100.44450747
75FGFR10.44265437
76TAOK30.42262373
77MAP4K20.41942547
78ATM0.41247149
79PRKCG0.38471462
80CSNK1G30.37517731
81CSNK1D0.36247306
82BRSK20.36180482
83TIE10.34978043
84CSNK1G20.34469043
85MAP3K120.34169500
86PHKG20.33494065
87PHKG10.33494065
88ERBB30.33347315
89LRRK20.31476704
90CDK190.30742494
91MAP3K130.28878802
92AURKA0.28133330
93CDK70.27048415
94ADRBK10.26596387
95MATK0.25579428
96PRKCE0.24644144
97PRKDC0.24194609
98BRAF0.23934056
99PRKD30.23828287
100TYRO30.23084169

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.61577754
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61914661
3Ribosome_Homo sapiens_hsa030103.24524204
4RNA polymerase_Homo sapiens_hsa030203.07747379
5Mismatch repair_Homo sapiens_hsa034302.98618651
6DNA replication_Homo sapiens_hsa030302.82255608
7RNA transport_Homo sapiens_hsa030132.67121665
8Oxidative phosphorylation_Homo sapiens_hsa001902.62767847
9RNA degradation_Homo sapiens_hsa030182.53548061
10Protein export_Homo sapiens_hsa030602.51416341
11Spliceosome_Homo sapiens_hsa030402.39781303
12One carbon pool by folate_Homo sapiens_hsa006702.34532255
13Parkinsons disease_Homo sapiens_hsa050122.28706617
14Non-homologous end-joining_Homo sapiens_hsa034502.28562157
15Homologous recombination_Homo sapiens_hsa034402.18417792
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13165992
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79755532
18Vitamin B6 metabolism_Homo sapiens_hsa007501.74275677
19Basal transcription factors_Homo sapiens_hsa030221.74241519
20Propanoate metabolism_Homo sapiens_hsa006401.72731294
21Huntingtons disease_Homo sapiens_hsa050161.63479828
22Nucleotide excision repair_Homo sapiens_hsa034201.60657933
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57662185
24Base excision repair_Homo sapiens_hsa034101.57631976
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.51572158
26Pyrimidine metabolism_Homo sapiens_hsa002401.49147669
27Asthma_Homo sapiens_hsa053101.37432558
28Sulfur metabolism_Homo sapiens_hsa009201.34410067
29Fanconi anemia pathway_Homo sapiens_hsa034601.31387449
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27553369
31Alzheimers disease_Homo sapiens_hsa050101.22845084
32Selenocompound metabolism_Homo sapiens_hsa004501.22813132
33Allograft rejection_Homo sapiens_hsa053301.20811444
34mRNA surveillance pathway_Homo sapiens_hsa030151.18779815
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.18720523
36Purine metabolism_Homo sapiens_hsa002301.16466579
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15827102
38Linoleic acid metabolism_Homo sapiens_hsa005911.05369791
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04798591
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03474501
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02297952
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00448636
43Autoimmune thyroid disease_Homo sapiens_hsa053200.99904199
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95576774
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92185121
46Pyruvate metabolism_Homo sapiens_hsa006200.90054307
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88698714
48Cell cycle_Homo sapiens_hsa041100.85358850
49Nitrogen metabolism_Homo sapiens_hsa009100.82282363
50Primary immunodeficiency_Homo sapiens_hsa053400.81272852
51Cardiac muscle contraction_Homo sapiens_hsa042600.79924719
52Steroid biosynthesis_Homo sapiens_hsa001000.78809188
53Butanoate metabolism_Homo sapiens_hsa006500.78151420
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71286853
55beta-Alanine metabolism_Homo sapiens_hsa004100.69555474
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67126741
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65777722
58Tryptophan metabolism_Homo sapiens_hsa003800.64179804
59Metabolic pathways_Homo sapiens_hsa011000.64064816
60Peroxisome_Homo sapiens_hsa041460.63322359
61Caffeine metabolism_Homo sapiens_hsa002320.60497081
62Glutathione metabolism_Homo sapiens_hsa004800.56338958
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55513669
64Arachidonic acid metabolism_Homo sapiens_hsa005900.55363809
65Folate biosynthesis_Homo sapiens_hsa007900.54766959
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53503505
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52792936
68Fat digestion and absorption_Homo sapiens_hsa049750.52162931
69Epstein-Barr virus infection_Homo sapiens_hsa051690.51648037
70Phototransduction_Homo sapiens_hsa047440.51172260
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51101143
72Fatty acid degradation_Homo sapiens_hsa000710.51024402
73Carbon metabolism_Homo sapiens_hsa012000.50932799
74Ether lipid metabolism_Homo sapiens_hsa005650.49441292
75p53 signaling pathway_Homo sapiens_hsa041150.45202504
76Type I diabetes mellitus_Homo sapiens_hsa049400.43130096
77Arginine and proline metabolism_Homo sapiens_hsa003300.40946630
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.40904421
79Systemic lupus erythematosus_Homo sapiens_hsa053220.39352003
80Oocyte meiosis_Homo sapiens_hsa041140.37327090
81Vitamin digestion and absorption_Homo sapiens_hsa049770.37326706
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37093170
83Retinol metabolism_Homo sapiens_hsa008300.36887621
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36738885
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35933058
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35655602
87Chemical carcinogenesis_Homo sapiens_hsa052040.33848925
88Fatty acid metabolism_Homo sapiens_hsa012120.31903315
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30874079
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29954488
91Nicotine addiction_Homo sapiens_hsa050330.29459438
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.25527431
93Regulation of autophagy_Homo sapiens_hsa041400.25210426
94Rheumatoid arthritis_Homo sapiens_hsa053230.25124046
95Collecting duct acid secretion_Homo sapiens_hsa049660.24865970
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24195911
97Graft-versus-host disease_Homo sapiens_hsa053320.19843972
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19150948
99Fatty acid elongation_Homo sapiens_hsa000620.18878519
100Antigen processing and presentation_Homo sapiens_hsa046120.17927556

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