Rank | Gene Set | Z-score |
---|---|---|
1 | DNA deamination (GO:0045006) | 5.53553465 |
2 | proteasome assembly (GO:0043248) | 4.43938987 |
3 | rRNA modification (GO:0000154) | 4.35938228 |
4 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.26284079 |
5 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.26284079 |
6 | rRNA methylation (GO:0031167) | 4.01270274 |
7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.89778805 |
8 | pseudouridine synthesis (GO:0001522) | 3.72006589 |
9 | chromatin remodeling at centromere (GO:0031055) | 3.68830370 |
10 | mitochondrial RNA metabolic process (GO:0000959) | 3.65805588 |
11 | CENP-A containing nucleosome assembly (GO:0034080) | 3.61169902 |
12 | respiratory chain complex IV assembly (GO:0008535) | 3.51415415 |
13 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.48347529 |
14 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.48347529 |
15 | isotype switching (GO:0045190) | 3.48347529 |
16 | maturation of 5.8S rRNA (GO:0000460) | 3.47394454 |
17 | DNA double-strand break processing (GO:0000729) | 3.46046773 |
18 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.45596156 |
19 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.41334728 |
20 | NADH dehydrogenase complex assembly (GO:0010257) | 3.41334728 |
21 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.41334728 |
22 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.37172517 |
23 | chaperone-mediated protein transport (GO:0072321) | 3.36226501 |
24 | IMP biosynthetic process (GO:0006188) | 3.31414723 |
25 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.31030553 |
26 | termination of RNA polymerase III transcription (GO:0006386) | 3.31030553 |
27 | protein complex biogenesis (GO:0070271) | 3.29105566 |
28 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.28813693 |
29 | replication fork processing (GO:0031297) | 3.27100632 |
30 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.26225087 |
31 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.25674637 |
32 | ribosome assembly (GO:0042255) | 3.25376191 |
33 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.24212004 |
34 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.24212004 |
35 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.24212004 |
36 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.23846578 |
37 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.23026653 |
38 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.23011665 |
39 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.22175507 |
40 | protein-cofactor linkage (GO:0018065) | 3.22024816 |
41 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.21187028 |
42 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.21187028 |
43 | tRNA processing (GO:0008033) | 3.19847844 |
44 | synapsis (GO:0007129) | 3.19761496 |
45 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.17435329 |
46 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.17435329 |
47 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.16814697 |
48 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.14162966 |
49 | tRNA modification (GO:0006400) | 3.11574844 |
50 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.11156799 |
51 | ribosome biogenesis (GO:0042254) | 3.10314568 |
52 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.09414632 |
53 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.09414632 |
54 | resolution of meiotic recombination intermediates (GO:0000712) | 3.09185485 |
55 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.08935758 |
56 | histone exchange (GO:0043486) | 3.08915620 |
57 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.06677689 |
58 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.05738280 |
59 | negative regulation of ligase activity (GO:0051352) | 3.05738280 |
60 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.04507337 |
61 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.04507337 |
62 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.03802613 |
63 | protein deneddylation (GO:0000338) | 3.02229166 |
64 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.01946196 |
65 | cullin deneddylation (GO:0010388) | 3.00976947 |
66 | ATP synthesis coupled proton transport (GO:0015986) | 3.00620869 |
67 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.00620869 |
68 | protein neddylation (GO:0045116) | 2.97952954 |
69 | viral mRNA export from host cell nucleus (GO:0046784) | 2.97647059 |
70 | tRNA metabolic process (GO:0006399) | 2.96558853 |
71 | rRNA processing (GO:0006364) | 2.94841577 |
72 | ribosomal small subunit assembly (GO:0000028) | 2.92856188 |
73 | aldehyde catabolic process (GO:0046185) | 2.92657590 |
74 | response to pheromone (GO:0019236) | 2.92324613 |
75 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.89082929 |
76 | IMP metabolic process (GO:0046040) | 2.88145191 |
77 | cytochrome complex assembly (GO:0017004) | 2.86938425 |
78 | rRNA metabolic process (GO:0016072) | 2.85435909 |
79 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 2.85425253 |
80 | transcription from mitochondrial promoter (GO:0006390) | 2.81672319 |
81 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.81011723 |
82 | cytidine catabolic process (GO:0006216) | 2.80454116 |
83 | cytidine deamination (GO:0009972) | 2.80454116 |
84 | cytidine metabolic process (GO:0046087) | 2.80454116 |
85 | formation of translation preinitiation complex (GO:0001731) | 2.78794951 |
86 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.74009761 |
87 | regulation of immunoglobulin secretion (GO:0051023) | 2.73287423 |
88 | cornea development in camera-type eye (GO:0061303) | 2.73273557 |
89 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.72439127 |
90 | adenosine metabolic process (GO:0046085) | 2.71416603 |
91 | platelet dense granule organization (GO:0060155) | 2.71246111 |
92 | regulation of centriole replication (GO:0046599) | 2.70835073 |
93 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.70330737 |
94 | termination of RNA polymerase I transcription (GO:0006363) | 2.70139818 |
95 | GTP biosynthetic process (GO:0006183) | 2.69615538 |
96 | ncRNA metabolic process (GO:0034660) | 2.69320852 |
97 | purine nucleobase biosynthetic process (GO:0009113) | 2.68921322 |
98 | ncRNA processing (GO:0034470) | 2.68412821 |
99 | nucleobase biosynthetic process (GO:0046112) | 2.66640535 |
100 | somatic diversification of immunoglobulins (GO:0016445) | 2.65870897 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.43434208 |
2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.27755978 |
3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.90039644 |
4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.64014800 |
5 | VDR_22108803_ChIP-Seq_LS180_Human | 2.95007973 |
6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.94049732 |
7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.91005371 |
8 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.70432700 |
9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.70164198 |
10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.60618026 |
11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.55561253 |
12 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.55243011 |
13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.45333212 |
14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.44054149 |
15 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.40260598 |
16 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.18698718 |
17 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.18469783 |
18 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.17956409 |
19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.17722058 |
20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.16218328 |
21 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.12352665 |
22 | MYC_18940864_ChIP-ChIP_HL60_Human | 2.05431327 |
23 | EWS_26573619_Chip-Seq_HEK293_Human | 2.04254446 |
24 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.02380645 |
25 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.95912449 |
26 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.94711366 |
27 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.89459302 |
28 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.85052408 |
29 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.83130714 |
30 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.81807393 |
31 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.76217646 |
32 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.73194120 |
33 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.68218816 |
34 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.66016378 |
35 | FUS_26573619_Chip-Seq_HEK293_Human | 1.64965687 |
36 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.60783745 |
37 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.56962154 |
38 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.56824398 |
39 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.56695323 |
40 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.53442429 |
41 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.46306365 |
42 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.45814853 |
43 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.45623757 |
44 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.39072516 |
45 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.36644639 |
46 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.34909556 |
47 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.34543343 |
48 | P300_19829295_ChIP-Seq_ESCs_Human | 1.33118249 |
49 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.32949017 |
50 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.30816179 |
51 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.30613933 |
52 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.29057450 |
53 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.27528947 |
54 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.27413868 |
55 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.24872175 |
56 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.24317508 |
57 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.23003811 |
58 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.23003811 |
59 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.20353508 |
60 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.20006103 |
61 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.18974287 |
62 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.18914737 |
63 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.14677268 |
64 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.14677268 |
65 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.13459470 |
66 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.12720841 |
67 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.12366303 |
68 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.10857588 |
69 | AR_20517297_ChIP-Seq_VCAP_Human | 1.10575348 |
70 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.10096552 |
71 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.08430500 |
72 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.08260320 |
73 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.06591920 |
74 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.06412012 |
75 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.05358532 |
76 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.03852132 |
77 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.03290411 |
78 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.01418671 |
79 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.01061366 |
80 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.00885341 |
81 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.00885341 |
82 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.99774654 |
83 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.99202715 |
84 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.99030791 |
85 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.98369961 |
86 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.96973994 |
87 | GATA3_26560356_Chip-Seq_TH2_Human | 0.96692834 |
88 | NCOR_22424771_ChIP-Seq_293T_Human | 0.94737456 |
89 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.94165384 |
90 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.92883810 |
91 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.92416229 |
92 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.92352943 |
93 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.91969857 |
94 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.91531931 |
95 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.90783611 |
96 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.90570041 |
97 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.89722339 |
98 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.89707379 |
99 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.89062779 |
100 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.87936396 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0006292_abnormal_olfactory_placode | 3.92636852 |
2 | MP0008877_abnormal_DNA_methylation | 3.81469978 |
3 | MP0002102_abnormal_ear_morphology | 3.47479927 |
4 | MP0008058_abnormal_DNA_repair | 2.67252589 |
5 | MP0006072_abnormal_retinal_apoptosis | 2.66645676 |
6 | MP0010094_abnormal_chromosome_stability | 2.66109810 |
7 | MP0002138_abnormal_hepatobiliary_system | 2.25949458 |
8 | MP0002938_white_spotting | 2.21110364 |
9 | MP0003693_abnormal_embryo_hatching | 2.12438671 |
10 | MP0008789_abnormal_olfactory_epithelium | 2.08916717 |
11 | MP0008872_abnormal_physiological_respon | 2.08659857 |
12 | MP0008875_abnormal_xenobiotic_pharmacok | 2.07407894 |
13 | MP0003786_premature_aging | 2.02914460 |
14 | MP0004147_increased_porphyrin_level | 2.02223044 |
15 | MP0005671_abnormal_response_to | 2.02166568 |
16 | MP0003806_abnormal_nucleotide_metabolis | 1.94944332 |
17 | MP0003787_abnormal_imprinting | 1.91980144 |
18 | MP0003567_abnormal_fetal_cardiomyocyte | 1.88739999 |
19 | MP0003718_maternal_effect | 1.82609549 |
20 | MP0000372_irregular_coat_pigmentation | 1.77481938 |
21 | MP0005646_abnormal_pituitary_gland | 1.76043821 |
22 | MP0005645_abnormal_hypothalamus_physiol | 1.71547742 |
23 | MP0005551_abnormal_eye_electrophysiolog | 1.70502413 |
24 | MP0001835_abnormal_antigen_presentation | 1.65148147 |
25 | MP0005253_abnormal_eye_physiology | 1.60890180 |
26 | MP0009697_abnormal_copulation | 1.60865922 |
27 | MP0005075_abnormal_melanosome_morpholog | 1.60792326 |
28 | MP0001764_abnormal_homeostasis | 1.59828771 |
29 | MP0002736_abnormal_nociception_after | 1.57151654 |
30 | MP0004957_abnormal_blastocyst_morpholog | 1.57147586 |
31 | MP0006036_abnormal_mitochondrial_physio | 1.52429888 |
32 | MP0001968_abnormal_touch/_nociception | 1.51792157 |
33 | MP0003195_calcinosis | 1.50677303 |
34 | MP0008057_abnormal_DNA_replication | 1.49221030 |
35 | MP0002160_abnormal_reproductive_system | 1.47757377 |
36 | MP0005394_taste/olfaction_phenotype | 1.45631677 |
37 | MP0005499_abnormal_olfactory_system | 1.45631677 |
38 | MP0002638_abnormal_pupillary_reflex | 1.42508965 |
39 | MP0003646_muscle_fatigue | 1.40829738 |
40 | MP0002837_dystrophic_cardiac_calcinosis | 1.35960233 |
41 | MP0001293_anophthalmia | 1.35516432 |
42 | MP0005084_abnormal_gallbladder_morpholo | 1.33132000 |
43 | MP0000569_abnormal_digit_pigmentation | 1.31561982 |
44 | MP0008995_early_reproductive_senescence | 1.30532628 |
45 | MP0005085_abnormal_gallbladder_physiolo | 1.28730096 |
46 | MP0005389_reproductive_system_phenotype | 1.28091705 |
47 | MP0001873_stomach_inflammation | 1.23664741 |
48 | MP0002876_abnormal_thyroid_physiology | 1.22807591 |
49 | MP0003111_abnormal_nucleus_morphology | 1.22329345 |
50 | MP0006035_abnormal_mitochondrial_morpho | 1.19025579 |
51 | MP0004885_abnormal_endolymph | 1.18847421 |
52 | MP0003186_abnormal_redox_activity | 1.17559114 |
53 | MP0005377_hearing/vestibular/ear_phenot | 1.16699827 |
54 | MP0003878_abnormal_ear_physiology | 1.16699827 |
55 | MP0001919_abnormal_reproductive_system | 1.12710418 |
56 | MP0004145_abnormal_muscle_electrophysio | 1.10474179 |
57 | MP0002210_abnormal_sex_determination | 1.06767919 |
58 | MP0001984_abnormal_olfaction | 1.05763901 |
59 | MP0001661_extended_life_span | 1.05559825 |
60 | MP0002006_tumorigenesis | 1.03567297 |
61 | MP0003077_abnormal_cell_cycle | 1.02642923 |
62 | MP0005360_urolithiasis | 1.01826366 |
63 | MP0000383_abnormal_hair_follicle | 0.98562278 |
64 | MP0001929_abnormal_gametogenesis | 0.97757870 |
65 | MP0008007_abnormal_cellular_replicative | 0.93978869 |
66 | MP0000613_abnormal_salivary_gland | 0.92657673 |
67 | MP0009333_abnormal_splenocyte_physiolog | 0.92173539 |
68 | MP0000653_abnormal_sex_gland | 0.92035287 |
69 | MP0002148_abnormal_hypersensitivity_rea | 0.89785977 |
70 | MP0001119_abnormal_female_reproductive | 0.89784048 |
71 | MP0002163_abnormal_gland_morphology | 0.89775561 |
72 | MP0000647_abnormal_sebaceous_gland | 0.89238289 |
73 | MP0001145_abnormal_male_reproductive | 0.88824771 |
74 | MP0005410_abnormal_fertilization | 0.88789779 |
75 | MP0001529_abnormal_vocalization | 0.88019544 |
76 | MP0002166_altered_tumor_susceptibility | 0.85556602 |
77 | MP0004142_abnormal_muscle_tone | 0.83454017 |
78 | MP0003011_delayed_dark_adaptation | 0.83409689 |
79 | MP0002095_abnormal_skin_pigmentation | 0.83236735 |
80 | MP0002234_abnormal_pharynx_morphology | 0.79928173 |
81 | MP0002272_abnormal_nervous_system | 0.79256904 |
82 | MP0004043_abnormal_pH_regulation | 0.79037701 |
83 | MP0003121_genomic_imprinting | 0.78685882 |
84 | MP0001188_hyperpigmentation | 0.78391177 |
85 | MP0003937_abnormal_limbs/digits/tail_de | 0.78134102 |
86 | MP0006276_abnormal_autonomic_nervous | 0.76050078 |
87 | MP0005379_endocrine/exocrine_gland_phen | 0.75710823 |
88 | MP0003119_abnormal_digestive_system | 0.75542737 |
89 | MP0003252_abnormal_bile_duct | 0.75234212 |
90 | MP0000631_abnormal_neuroendocrine_gland | 0.74533625 |
91 | MP0000685_abnormal_immune_system | 0.73989093 |
92 | MP0005195_abnormal_posterior_eye | 0.73764852 |
93 | MP0005332_abnormal_amino_acid | 0.73513431 |
94 | MP0001485_abnormal_pinna_reflex | 0.73483814 |
95 | MP0005391_vision/eye_phenotype | 0.73469199 |
96 | MP0001800_abnormal_humoral_immune | 0.72467665 |
97 | MP0010386_abnormal_urinary_bladder | 0.72352324 |
98 | MP0004133_heterotaxia | 0.71678634 |
99 | MP0001501_abnormal_sleep_pattern | 0.71442154 |
100 | MP0002751_abnormal_autonomic_nervous | 0.70224092 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 3.71246118 |
2 | Increased CSF lactate (HP:0002490) | 3.53047336 |
3 | Mitochondrial inheritance (HP:0001427) | 3.50282568 |
4 | Acute encephalopathy (HP:0006846) | 3.39325128 |
5 | Pancreatic cysts (HP:0001737) | 3.34563952 |
6 | Abnormality of alanine metabolism (HP:0010916) | 3.33255667 |
7 | Hyperalaninemia (HP:0003348) | 3.33255667 |
8 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.33255667 |
9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.08400574 |
10 | IgG deficiency (HP:0004315) | 3.05458700 |
11 | Progressive macrocephaly (HP:0004481) | 3.04425709 |
12 | Methylmalonic acidemia (HP:0002912) | 3.03235078 |
13 | Molar tooth sign on MRI (HP:0002419) | 2.92909530 |
14 | Abnormality of midbrain morphology (HP:0002418) | 2.92909530 |
15 | Pancreatic fibrosis (HP:0100732) | 2.91525713 |
16 | Severe combined immunodeficiency (HP:0004430) | 2.90917281 |
17 | True hermaphroditism (HP:0010459) | 2.88445984 |
18 | Hepatocellular necrosis (HP:0001404) | 2.88304621 |
19 | Increased serum lactate (HP:0002151) | 2.84956383 |
20 | Constricted visual fields (HP:0001133) | 2.82028510 |
21 | Methylmalonic aciduria (HP:0012120) | 2.79089981 |
22 | Hepatic necrosis (HP:0002605) | 2.77912121 |
23 | Abnormality of B cell number (HP:0010975) | 2.74527784 |
24 | Increased hepatocellular lipid droplets (HP:0006565) | 2.74416698 |
25 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.73444170 |
26 | Renal cortical cysts (HP:0000803) | 2.69385180 |
27 | B lymphocytopenia (HP:0010976) | 2.68998818 |
28 | Cerebral edema (HP:0002181) | 2.68145799 |
29 | Congenital stationary night blindness (HP:0007642) | 2.59670237 |
30 | Abolished electroretinogram (ERG) (HP:0000550) | 2.59465888 |
31 | Nephronophthisis (HP:0000090) | 2.56689782 |
32 | Lipid accumulation in hepatocytes (HP:0006561) | 2.56270536 |
33 | Colon cancer (HP:0003003) | 2.53097728 |
34 | Abnormality of the renal cortex (HP:0011035) | 2.49955772 |
35 | Abnormality of serum amino acid levels (HP:0003112) | 2.49245708 |
36 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.48986501 |
37 | Hypoplasia of the fovea (HP:0007750) | 2.48986501 |
38 | Pendular nystagmus (HP:0012043) | 2.47203080 |
39 | Abnormality of the labia minora (HP:0012880) | 2.47142665 |
40 | Thyroiditis (HP:0100646) | 2.45773033 |
41 | Optic disc pallor (HP:0000543) | 2.44691207 |
42 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.40892002 |
43 | Hypoproteinemia (HP:0003075) | 2.38413147 |
44 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.38399191 |
45 | Volvulus (HP:0002580) | 2.37956507 |
46 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.36567744 |
47 | Lactic acidosis (HP:0003128) | 2.33297313 |
48 | Stomatitis (HP:0010280) | 2.32570508 |
49 | Combined immunodeficiency (HP:0005387) | 2.29953678 |
50 | Hyperglycinemia (HP:0002154) | 2.24326619 |
51 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.23721455 |
52 | Abnormality of the pons (HP:0007361) | 2.22701156 |
53 | Meckel diverticulum (HP:0002245) | 2.22659468 |
54 | Attenuation of retinal blood vessels (HP:0007843) | 2.22249418 |
55 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.21650006 |
56 | 3-Methylglutaconic aciduria (HP:0003535) | 2.19420454 |
57 | Abnormality of the ileum (HP:0001549) | 2.18307403 |
58 | Abnormality of the fovea (HP:0000493) | 2.15569414 |
59 | Hyperglycinuria (HP:0003108) | 2.12353382 |
60 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.09929009 |
61 | Abnormality of the renal collecting system (HP:0004742) | 2.08956549 |
62 | Congenital, generalized hypertrichosis (HP:0004540) | 2.07561576 |
63 | Lethargy (HP:0001254) | 2.02647988 |
64 | Hypoplasia of the pons (HP:0012110) | 2.02346066 |
65 | Abnormality of glycine metabolism (HP:0010895) | 2.01740115 |
66 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.01740115 |
67 | Abnormality of the renal medulla (HP:0100957) | 2.00569683 |
68 | Duplicated collecting system (HP:0000081) | 2.00482003 |
69 | Abnormality of the prostate (HP:0008775) | 1.97452288 |
70 | Leukodystrophy (HP:0002415) | 1.96829033 |
71 | Supernumerary spleens (HP:0009799) | 1.96686520 |
72 | Abnormal biliary tract physiology (HP:0012439) | 1.94546987 |
73 | Bile duct proliferation (HP:0001408) | 1.94546987 |
74 | Horseshoe kidney (HP:0000085) | 1.94051129 |
75 | Chromsome breakage (HP:0040012) | 1.93951935 |
76 | Renal Fanconi syndrome (HP:0001994) | 1.92860956 |
77 | Abnormality of DNA repair (HP:0003254) | 1.89026586 |
78 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.87636120 |
79 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.86789085 |
80 | Generalized aminoaciduria (HP:0002909) | 1.85768583 |
81 | Abnormality of chromosome stability (HP:0003220) | 1.84547593 |
82 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.83850223 |
83 | Abnormality of vitamin B metabolism (HP:0004340) | 1.83032547 |
84 | Respiratory failure (HP:0002878) | 1.80968980 |
85 | Abnormality of methionine metabolism (HP:0010901) | 1.80009492 |
86 | Abnormality of urine glucose concentration (HP:0011016) | 1.79376616 |
87 | Glycosuria (HP:0003076) | 1.79376616 |
88 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.78684322 |
89 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.78238126 |
90 | Exercise intolerance (HP:0003546) | 1.78098764 |
91 | Decreased central vision (HP:0007663) | 1.77224727 |
92 | Abnormality of eosinophils (HP:0001879) | 1.76952368 |
93 | Poor head control (HP:0002421) | 1.75463840 |
94 | Progressive microcephaly (HP:0000253) | 1.74691396 |
95 | Carpal bone hypoplasia (HP:0001498) | 1.73590253 |
96 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.72355767 |
97 | Abnormal protein glycosylation (HP:0012346) | 1.72355767 |
98 | Abnormal glycosylation (HP:0012345) | 1.72355767 |
99 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.72355767 |
100 | Chronic hepatic failure (HP:0100626) | 1.72075203 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 3.67487521 |
2 | ZAK | 3.29088140 |
3 | EIF2AK3 | 3.14767113 |
4 | NEK1 | 2.84380583 |
5 | MAP4K2 | 2.84211700 |
6 | TSSK6 | 2.70202181 |
7 | NUAK1 | 2.48903082 |
8 | BUB1 | 2.47270375 |
9 | TLK1 | 2.34210845 |
10 | SRPK1 | 2.31859708 |
11 | STK16 | 2.30125378 |
12 | TRIM28 | 2.20821525 |
13 | VRK1 | 2.19839679 |
14 | MST4 | 2.14587731 |
15 | GRK1 | 2.04559500 |
16 | MKNK2 | 1.98573980 |
17 | TXK | 1.97880174 |
18 | TAF1 | 1.89182874 |
19 | ADRBK2 | 1.82728889 |
20 | FRK | 1.80938787 |
21 | PLK3 | 1.80333124 |
22 | BMPR1B | 1.77428045 |
23 | WNK3 | 1.75749039 |
24 | EIF2AK1 | 1.75060679 |
25 | MKNK1 | 1.65506599 |
26 | PLK4 | 1.60018937 |
27 | WNK4 | 1.43344101 |
28 | PBK | 1.41421860 |
29 | TAOK3 | 1.31368724 |
30 | STK39 | 1.26083173 |
31 | OXSR1 | 1.24028234 |
32 | CDC7 | 1.23264578 |
33 | EIF2AK2 | 1.21306375 |
34 | PLK2 | 1.18118598 |
35 | BCKDK | 1.14565268 |
36 | MAPK13 | 1.12522694 |
37 | CSNK1G1 | 1.01933683 |
38 | ACVR1B | 1.00636166 |
39 | CDK19 | 0.99723987 |
40 | CSNK1G3 | 0.95784530 |
41 | TTK | 0.95136200 |
42 | ATR | 0.94197844 |
43 | STK38L | 0.92312188 |
44 | TGFBR1 | 0.88778139 |
45 | PDK2 | 0.87492752 |
46 | TEC | 0.86262175 |
47 | CSNK1G2 | 0.84988830 |
48 | CSNK1A1L | 0.83698000 |
49 | DYRK2 | 0.80655474 |
50 | DAPK1 | 0.79438702 |
51 | NME1 | 0.78453981 |
52 | INSRR | 0.78372108 |
53 | CDK8 | 0.76861275 |
54 | KDR | 0.76711029 |
55 | PLK1 | 0.76137670 |
56 | WEE1 | 0.69957461 |
57 | TNIK | 0.66592974 |
58 | PIK3CG | 0.64614817 |
59 | TIE1 | 0.64055233 |
60 | PHKG1 | 0.63996795 |
61 | PHKG2 | 0.63996795 |
62 | AURKB | 0.63898573 |
63 | RPS6KA5 | 0.62152809 |
64 | RPS6KA4 | 0.61025705 |
65 | PASK | 0.58873587 |
66 | ERBB3 | 0.58649583 |
67 | CDK9 | 0.56889627 |
68 | MAP3K4 | 0.55604025 |
69 | ITK | 0.54249103 |
70 | CASK | 0.53992875 |
71 | BRSK2 | 0.52273020 |
72 | MAPKAPK5 | 0.49987243 |
73 | PRKCE | 0.49845722 |
74 | MAPKAPK3 | 0.48480993 |
75 | PRKCG | 0.47998412 |
76 | CHEK2 | 0.46460555 |
77 | ADRBK1 | 0.46359209 |
78 | ATM | 0.45687350 |
79 | BCR | 0.45438609 |
80 | CSNK2A2 | 0.44910088 |
81 | ALK | 0.44888592 |
82 | CDK7 | 0.42586909 |
83 | CSNK2A1 | 0.42522395 |
84 | CSNK1A1 | 0.40336071 |
85 | STK3 | 0.39023391 |
86 | PRKCQ | 0.38700684 |
87 | CCNB1 | 0.37636505 |
88 | CSNK1E | 0.36499072 |
89 | RPS6KB2 | 0.36333208 |
90 | AURKA | 0.33921293 |
91 | IKBKB | 0.33905206 |
92 | MAP3K12 | 0.33546209 |
93 | GRK5 | 0.33213696 |
94 | DAPK3 | 0.32184362 |
95 | TESK2 | 0.31759622 |
96 | PAK3 | 0.28785655 |
97 | PTK2B | 0.28717952 |
98 | CSNK1D | 0.26749028 |
99 | NEK2 | 0.26700293 |
100 | CHEK1 | 0.25537475 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.27607989 |
2 | Protein export_Homo sapiens_hsa03060 | 2.98739825 |
3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.77356612 |
4 | RNA polymerase_Homo sapiens_hsa03020 | 2.57764194 |
5 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.52258316 |
6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.31256427 |
7 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.12153071 |
8 | Homologous recombination_Homo sapiens_hsa03440 | 2.07050092 |
9 | Mismatch repair_Homo sapiens_hsa03430 | 2.06018456 |
10 | Ribosome_Homo sapiens_hsa03010 | 1.94859096 |
11 | RNA transport_Homo sapiens_hsa03013 | 1.94850436 |
12 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.94813909 |
13 | DNA replication_Homo sapiens_hsa03030 | 1.94708379 |
14 | Basal transcription factors_Homo sapiens_hsa03022 | 1.92759088 |
15 | Asthma_Homo sapiens_hsa05310 | 1.92398298 |
16 | Parkinsons disease_Homo sapiens_hsa05012 | 1.86261651 |
17 | RNA degradation_Homo sapiens_hsa03018 | 1.84249022 |
18 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.82441462 |
19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.80719007 |
20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.76349742 |
21 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.66667979 |
22 | Spliceosome_Homo sapiens_hsa03040 | 1.64846118 |
23 | Allograft rejection_Homo sapiens_hsa05330 | 1.62407139 |
24 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.62355339 |
25 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.59315971 |
26 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.52417833 |
27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.49700496 |
28 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.47702255 |
29 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.41250914 |
30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.39194269 |
31 | Base excision repair_Homo sapiens_hsa03410 | 1.36752878 |
32 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.35702960 |
33 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.34462554 |
34 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.29639330 |
35 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.28554522 |
36 | Huntingtons disease_Homo sapiens_hsa05016 | 1.28197065 |
37 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.26448986 |
38 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.24811333 |
39 | Phototransduction_Homo sapiens_hsa04744 | 1.19258261 |
40 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.19191517 |
41 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.18429936 |
42 | Purine metabolism_Homo sapiens_hsa00230 | 1.17942995 |
43 | Peroxisome_Homo sapiens_hsa04146 | 1.16687539 |
44 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.11912190 |
45 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.10558107 |
46 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.10258071 |
47 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.08971809 |
48 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.06621623 |
49 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.05604164 |
50 | Sulfur relay system_Homo sapiens_hsa04122 | 1.03871789 |
51 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.03567791 |
52 | Alzheimers disease_Homo sapiens_hsa05010 | 1.00424413 |
53 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.83853421 |
54 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.82682349 |
55 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.82570023 |
56 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.81244566 |
57 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.76666372 |
58 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.76016032 |
59 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.74959216 |
60 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.73221651 |
61 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.73121250 |
62 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.71281653 |
63 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.71217926 |
64 | Retinol metabolism_Homo sapiens_hsa00830 | 0.70499238 |
65 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.69322684 |
66 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.69254321 |
67 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.66305161 |
68 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.66220960 |
69 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.65244836 |
70 | Metabolic pathways_Homo sapiens_hsa01100 | 0.64784150 |
71 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.64781036 |
72 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.64720028 |
73 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.62219024 |
74 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.60640918 |
75 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.60620908 |
76 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.60073156 |
77 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.58648622 |
78 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.57211634 |
79 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.56932728 |
80 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.55992393 |
81 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.54798929 |
82 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.54307974 |
83 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.52949360 |
84 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.52697962 |
85 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.52133449 |
86 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.50003274 |
87 | Cell cycle_Homo sapiens_hsa04110 | 0.49107191 |
88 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.47693505 |
89 | Nicotine addiction_Homo sapiens_hsa05033 | 0.46578351 |
90 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.43655901 |
91 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.42667008 |
92 | Carbon metabolism_Homo sapiens_hsa01200 | 0.42651313 |
93 | Olfactory transduction_Homo sapiens_hsa04740 | 0.42398956 |
94 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.42112324 |
95 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.38815185 |
96 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.38684766 |
97 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.37121188 |
98 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.36248942 |
99 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.35338686 |
100 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.33932263 |