NPM1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.55269905
2chaperone-mediated protein transport (GO:0072321)5.06124755
3gonadal mesoderm development (GO:0007506)5.04145604
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.95376931
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.95376931
6proteasome assembly (GO:0043248)4.79339612
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.66701633
8protein complex biogenesis (GO:0070271)4.51181941
9exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.39883986
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.36832910
11mitochondrial respiratory chain complex assembly (GO:0033108)4.31729688
12nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.17282250
13ATP synthesis coupled proton transport (GO:0015986)4.17066980
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.17066980
15regulation of chronic inflammatory response (GO:0002676)4.10389552
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.05971592
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.05971592
18NADH dehydrogenase complex assembly (GO:0010257)4.05971592
19maturation of SSU-rRNA (GO:0030490)4.03654663
20somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.93504185
21isotype switching (GO:0045190)3.93504185
22somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.93504185
23rRNA modification (GO:0000154)3.92957114
24cullin deneddylation (GO:0010388)3.90807503
25protein-cofactor linkage (GO:0018065)3.81471906
26maturation of 5.8S rRNA (GO:0000460)3.68302925
27protein deneddylation (GO:0000338)3.68257936
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67478665
29termination of RNA polymerase III transcription (GO:0006386)3.60962897
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.60962897
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54633661
32CENP-A containing nucleosome assembly (GO:0034080)3.53848712
33chromatin remodeling at centromere (GO:0031055)3.50647458
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.50623459
35transcription elongation from RNA polymerase I promoter (GO:0006362)3.50172466
36ribosomal large subunit biogenesis (GO:0042273)3.45333264
37peptidyl-histidine modification (GO:0018202)3.44700347
38ribosomal small subunit assembly (GO:0000028)3.39204564
39rRNA processing (GO:0006364)3.37165242
40cellular component biogenesis (GO:0044085)3.35929258
41protein neddylation (GO:0045116)3.35910277
42termination of RNA polymerase I transcription (GO:0006363)3.35894429
43respiratory electron transport chain (GO:0022904)3.35774445
44rRNA methylation (GO:0031167)3.34506549
45rRNA metabolic process (GO:0016072)3.29723204
46electron transport chain (GO:0022900)3.29605654
47respiratory chain complex IV assembly (GO:0008535)3.27911171
48translation (GO:0006412)3.25881007
49DNA damage response, detection of DNA damage (GO:0042769)3.25477785
50water-soluble vitamin biosynthetic process (GO:0042364)3.24960441
51cytochrome complex assembly (GO:0017004)3.24742016
52pseudouridine synthesis (GO:0001522)3.22794069
53tRNA processing (GO:0008033)3.18594562
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.18580108
55ribosome assembly (GO:0042255)3.16848822
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15248704
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08881883
58regulation of cellular amino acid metabolic process (GO:0006521)3.08603733
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08401250
60negative regulation of ligase activity (GO:0051352)3.08401250
61negative regulation of DNA-dependent DNA replication (GO:2000104)3.06005450
62ribonucleoprotein complex biogenesis (GO:0022613)3.05993363
63ribosome biogenesis (GO:0042254)3.05812176
64CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.04363689
65intracellular protein transmembrane import (GO:0044743)3.03816816
66RNA phosphodiester bond hydrolysis (GO:0090501)3.03069276
67DNA catabolic process, exonucleolytic (GO:0000738)3.02244708
68kynurenine metabolic process (GO:0070189)3.01668289
69nucleobase biosynthetic process (GO:0046112)2.99998964
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99411411
71histone exchange (GO:0043486)2.98702109
72tRNA metabolic process (GO:0006399)2.98309468
73RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.96593184
74kinetochore assembly (GO:0051382)2.95537063
75regulation of immunoglobulin secretion (GO:0051023)2.94134062
76somatic recombination of immunoglobulin gene segments (GO:0016447)2.93733100
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93084553
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93084553
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93084553
80mismatch repair (GO:0006298)2.92695650
81rRNA catabolic process (GO:0016075)2.92289057
82positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.91327911
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91225659
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91225659
85aldehyde catabolic process (GO:0046185)2.91171799
86telomere maintenance via telomerase (GO:0007004)2.90161897
87GTP biosynthetic process (GO:0006183)2.88585728
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87600172
89response to pheromone (GO:0019236)2.87378707
90replication fork processing (GO:0031297)2.86842606
91transcription initiation from RNA polymerase I promoter (GO:0006361)2.86664263
92transcription from RNA polymerase I promoter (GO:0006360)2.86574042
93ncRNA processing (GO:0034470)2.85476588
94positive regulation of DNA recombination (GO:0045911)2.83473201
95viral transcription (GO:0019083)2.83390319
96ncRNA metabolic process (GO:0034660)2.82401426
97double-strand break repair via homologous recombination (GO:0000724)2.81916868
98ribosomal small subunit biogenesis (GO:0042274)2.81773941
99translational termination (GO:0006415)2.81032931
100SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79977854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.97050100
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.54792636
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.15540645
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.42025159
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20268173
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08252963
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.02827768
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.90748289
9VDR_23849224_ChIP-Seq_CD4+_Human2.79987964
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67628605
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62447101
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60024530
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57607449
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57170895
15VDR_22108803_ChIP-Seq_LS180_Human2.45921275
16FOXP3_21729870_ChIP-Seq_TREG_Human2.42453383
17ELK1_19687146_ChIP-ChIP_HELA_Human2.42292415
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38663316
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.35539054
20ZNF274_21170338_ChIP-Seq_K562_Hela2.32159043
21TAF15_26573619_Chip-Seq_HEK293_Human2.30094431
22E2F7_22180533_ChIP-Seq_HELA_Human2.26313127
23MYC_18940864_ChIP-ChIP_HL60_Human2.23076379
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18005883
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.08200524
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97448575
27FUS_26573619_Chip-Seq_HEK293_Human1.94861395
28EWS_26573619_Chip-Seq_HEK293_Human1.93305311
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89108489
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85452375
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.83124674
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80179959
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77909690
34TTF2_22483619_ChIP-Seq_HELA_Human1.77783179
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73943996
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71364295
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65595622
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62395613
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48291216
40DCP1A_22483619_ChIP-Seq_HELA_Human1.46737964
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46495525
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42380391
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39579768
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39119882
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38942710
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38552389
47XRN2_22483619_ChIP-Seq_HELA_Human1.35502603
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33187146
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29439508
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28678165
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28204591
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.28029706
53TP53_22573176_ChIP-Seq_HFKS_Human1.25868998
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24389964
55GABP_19822575_ChIP-Seq_HepG2_Human1.23634562
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21116155
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21024096
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20200939
59GATA1_22025678_ChIP-Seq_K562_Human1.18620543
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16549028
61IRF1_19129219_ChIP-ChIP_H3396_Human1.16199587
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14853908
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.14853908
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14019139
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.13465980
66GBX2_23144817_ChIP-Seq_PC3_Human1.10094119
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09610257
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.09504212
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08185604
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04971694
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04158810
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.03883846
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03322393
74ERG_20517297_ChIP-Seq_VCAP_Human0.99227738
75GATA3_26560356_Chip-Seq_TH2_Human0.99143664
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98046061
77PHF8_20622853_ChIP-Seq_HELA_Human0.97050983
78KDM5A_27292631_Chip-Seq_BREAST_Human0.96786707
79NANOG_19829295_ChIP-Seq_ESCs_Human0.96506865
80SOX2_19829295_ChIP-Seq_ESCs_Human0.96506865
81P300_19829295_ChIP-Seq_ESCs_Human0.94845861
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94655033
83RBPJ_21746931_ChIP-Seq_IB4_Human0.92761631
84CBP_20019798_ChIP-Seq_JUKART_Human0.92204796
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92204796
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92126538
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90391078
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88391063
89AR_20517297_ChIP-Seq_VCAP_Human0.87741928
90ETV1_20927104_ChIP-Seq_GIST48_Human0.87602533
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87249776
92ER_23166858_ChIP-Seq_MCF-7_Human0.85890038
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.85239405
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85225374
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84940675
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84530389
97NELFA_20434984_ChIP-Seq_ESCs_Mouse0.83920060
98GATA6_21074721_ChIP-Seq_CACO-2_Human0.83671180
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82960964
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.82773026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.24313420
2MP0005075_abnormal_melanosome_morpholog2.95021111
3MP0010094_abnormal_chromosome_stability2.93087111
4MP0008877_abnormal_DNA_methylation2.79284207
5MP0008058_abnormal_DNA_repair2.78577807
6MP0003195_calcinosis2.76925529
7MP0000685_abnormal_immune_system2.63557892
8MP0001835_abnormal_antigen_presentation2.63352382
9MP0002837_dystrophic_cardiac_calcinosis2.56964691
10MP0008875_abnormal_xenobiotic_pharmacok2.44709791
11MP0003252_abnormal_bile_duct2.28469062
12MP0003786_premature_aging2.21403687
13MP0005646_abnormal_pituitary_gland2.18148932
14MP0003718_maternal_effect2.13733616
15MP0005671_abnormal_response_to2.09388749
16MP0001348_abnormal_lacrimal_gland2.08067905
17MP0002735_abnormal_chemical_nociception1.98563491
18MP0008872_abnormal_physiological_respon1.94049392
19MP0000372_irregular_coat_pigmentation1.93240866
20MP0002396_abnormal_hematopoietic_system1.89055040
21MP0003567_abnormal_fetal_cardiomyocyte1.88191060
22MP0006036_abnormal_mitochondrial_physio1.82051116
23MP0002736_abnormal_nociception_after1.81663804
24MP0004147_increased_porphyrin_level1.81596543
25MP0004957_abnormal_blastocyst_morpholog1.79271020
26MP0001873_stomach_inflammation1.78114128
27MP0001188_hyperpigmentation1.74770855
28MP0002160_abnormal_reproductive_system1.67300789
29MP0001501_abnormal_sleep_pattern1.61964673
30MP0004145_abnormal_muscle_electrophysio1.58647386
31MP0005084_abnormal_gallbladder_morpholo1.58341856
32MP0004043_abnormal_pH_regulation1.57474448
33MP0008007_abnormal_cellular_replicative1.55946939
34MP0006072_abnormal_retinal_apoptosis1.53079364
35MP0008057_abnormal_DNA_replication1.52096785
36MP0005377_hearing/vestibular/ear_phenot1.50823715
37MP0003878_abnormal_ear_physiology1.50823715
38MP0004381_abnormal_hair_follicle1.48952365
39MP0001727_abnormal_embryo_implantation1.47080238
40MP0008995_early_reproductive_senescence1.46903144
41MP0003011_delayed_dark_adaptation1.45175293
42MP0001968_abnormal_touch/_nociception1.40819880
43MP0004019_abnormal_vitamin_homeostasis1.37059745
44MP0003283_abnormal_digestive_organ1.35112559
45MP0003787_abnormal_imprinting1.33004610
46MP0001800_abnormal_humoral_immune1.29638221
47MP0004215_abnormal_myocardial_fiber1.26895919
48MP0001764_abnormal_homeostasis1.25641313
49MP0009379_abnormal_foot_pigmentation1.24484826
50MP0002166_altered_tumor_susceptibility1.23664523
51MP0009764_decreased_sensitivity_to1.23294177
52MP0002163_abnormal_gland_morphology1.22950784
53MP0002006_tumorigenesis1.22878753
54MP0003077_abnormal_cell_cycle1.20136611
55MP0005389_reproductive_system_phenotype1.19967230
56MP0005387_immune_system_phenotype1.18638397
57MP0001790_abnormal_immune_system1.18638397
58MP0003693_abnormal_embryo_hatching1.17330524
59MP0002148_abnormal_hypersensitivity_rea1.17194707
60MP0005645_abnormal_hypothalamus_physiol1.17174177
61MP0005085_abnormal_gallbladder_physiolo1.16797859
62MP0003111_abnormal_nucleus_morphology1.12177456
63MP0003646_muscle_fatigue1.11522037
64MP0005174_abnormal_tail_pigmentation1.06932449
65MP0009785_altered_susceptibility_to1.01040234
66MP0009765_abnormal_xenobiotic_induced1.00022704
67MP0004885_abnormal_endolymph0.99854015
68MP0006035_abnormal_mitochondrial_morpho0.98134377
69MP0002277_abnormal_respiratory_mucosa0.95665735
70MP0009745_abnormal_behavioral_response0.93098841
71MP0000371_diluted_coat_color0.92997479
72MP0002095_abnormal_skin_pigmentation0.92699058
73MP0002138_abnormal_hepatobiliary_system0.92202302
74MP0002234_abnormal_pharynx_morphology0.90723665
75MP0009697_abnormal_copulation0.90422526
76MP0002102_abnormal_ear_morphology0.89875568
77MP0005253_abnormal_eye_physiology0.88530334
78MP0001986_abnormal_taste_sensitivity0.86983704
79MP0005551_abnormal_eye_electrophysiolog0.86620892
80MP0003137_abnormal_impulse_conducting0.86385722
81MP0005379_endocrine/exocrine_gland_phen0.85092400
82MP0000427_abnormal_hair_cycle0.84378245
83MP0002928_abnormal_bile_duct0.83464408
84MP0010386_abnormal_urinary_bladder0.83153656
85MP0005266_abnormal_metabolism0.80399524
86MP0009046_muscle_twitch0.80045813
87MP0008873_increased_physiological_sensi0.79501561
88MP0006082_CNS_inflammation0.77901563
89MP0003866_abnormal_defecation0.77552577
90MP0008932_abnormal_embryonic_tissue0.77119070
91MP0003186_abnormal_redox_activity0.77064087
92MP0005636_abnormal_mineral_homeostasis0.75645072
93MP0002272_abnormal_nervous_system0.75346084
94MP0001756_abnormal_urination0.74162531
95MP0001529_abnormal_vocalization0.72624322
96MP0005165_increased_susceptibility_to0.70340047
97MP0005367_renal/urinary_system_phenotyp0.69179963
98MP0000516_abnormal_urinary_system0.69179963
99MP0006292_abnormal_olfactory_placode0.68419797
100MP0008775_abnormal_heart_ventricle0.68071939

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.23063248
2Acute encephalopathy (HP:0006846)4.64100669
3Mitochondrial inheritance (HP:0001427)4.51208448
4Abnormal mitochondria in muscle tissue (HP:0008316)4.49912539
5Increased CSF lactate (HP:0002490)4.48917395
6Progressive macrocephaly (HP:0004481)4.35687681
7Increased hepatocellular lipid droplets (HP:0006565)3.85448363
8Lipid accumulation in hepatocytes (HP:0006561)3.68373774
9Hepatocellular necrosis (HP:0001404)3.52936648
103-Methylglutaconic aciduria (HP:0003535)3.37339239
11Chronic hepatic failure (HP:0100626)3.29424208
12Pancreatic cysts (HP:0001737)3.21795900
13Hepatic necrosis (HP:0002605)3.14096883
14Congenital, generalized hypertrichosis (HP:0004540)3.10231762
15Cerebral edema (HP:0002181)2.95809875
16Exertional dyspnea (HP:0002875)2.93024910
17IgG deficiency (HP:0004315)2.92556637
18Increased serum lactate (HP:0002151)2.91560753
19Stomatitis (HP:0010280)2.85403852
20Colon cancer (HP:0003003)2.84224552
21Leukodystrophy (HP:0002415)2.81580505
22Renal Fanconi syndrome (HP:0001994)2.78988327
23Delayed CNS myelination (HP:0002188)2.77298857
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75993390
25Pancreatic fibrosis (HP:0100732)2.72790006
26Optic disc pallor (HP:0000543)2.70935176
27Bile duct proliferation (HP:0001408)2.68797852
28Abnormal biliary tract physiology (HP:0012439)2.68797852
29Sensory axonal neuropathy (HP:0003390)2.64661990
30Lactic acidosis (HP:0003128)2.63616369
31Respiratory failure (HP:0002878)2.60546315
32Abnormality of renal resorption (HP:0011038)2.55456003
33Adactyly (HP:0009776)2.53681705
34Abnormality of T cell physiology (HP:0011840)2.53353827
35Congenital stationary night blindness (HP:0007642)2.47752636
36True hermaphroditism (HP:0010459)2.45746398
37Abnormality of the phalanges of the 2nd finger (HP:0009541)2.41710401
38Aplastic anemia (HP:0001915)2.40432567
39Pendular nystagmus (HP:0012043)2.37179562
40Progressive microcephaly (HP:0000253)2.35787728
41Abnormality of the renal cortex (HP:0011035)2.30995757
42Nephronophthisis (HP:0000090)2.30398973
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.24305664
44Asplenia (HP:0001746)2.23667315
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20830499
46Meckel diverticulum (HP:0002245)2.19810337
47Paralysis (HP:0003470)2.18402605
48Birth length less than 3rd percentile (HP:0003561)2.15005296
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.13060517
50Hypoplasia of the pons (HP:0012110)2.12946841
51Supernumerary spleens (HP:0009799)2.12595857
52Enlarged epiphyses (HP:0010580)2.12243176
53Lethargy (HP:0001254)2.10266053
54Exercise intolerance (HP:0003546)2.09269654
55Abolished electroretinogram (ERG) (HP:0000550)2.07359828
56Abnormality of the ileum (HP:0001549)2.04336123
57Fibular aplasia (HP:0002990)2.03237412
58Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.01033710
59Abnormality of the preputium (HP:0100587)2.00542805
60Hyperglycinemia (HP:0002154)2.00198224
61Type I transferrin isoform profile (HP:0003642)1.99843753
62Abnormality of the renal medulla (HP:0100957)1.99402809
63Pancytopenia (HP:0001876)1.98750682
64Severe combined immunodeficiency (HP:0004430)1.98488911
65Abnormality of the pons (HP:0007361)1.97373794
66CNS demyelination (HP:0007305)1.96825924
67Clubbing of toes (HP:0100760)1.95294335
68Increased IgM level (HP:0003496)1.94135674
69Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.91673832
70Short 1st metacarpal (HP:0010034)1.91673832
71Renal cortical cysts (HP:0000803)1.91531669
72Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90667408
73Abnormality of the proximal phalanges of the hand (HP:0009834)1.89491176
74Increased intramyocellular lipid droplets (HP:0012240)1.88476439
75Abnormality of alanine metabolism (HP:0010916)1.82951704
76Hyperalaninemia (HP:0003348)1.82951704
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82951704
78Blindness (HP:0000618)1.81879487
79Abnormality of T cells (HP:0002843)1.81702507
80Molar tooth sign on MRI (HP:0002419)1.81648872
81Abnormality of midbrain morphology (HP:0002418)1.81648872
82Poor head control (HP:0002421)1.80150752
83Male pseudohermaphroditism (HP:0000037)1.78555654
84Abnormality of the phalanges of the 5th finger (HP:0004213)1.77781395
85Macrocytic anemia (HP:0001972)1.77004190
86Cleft eyelid (HP:0000625)1.76368149
87Type II lissencephaly (HP:0007260)1.75127114
88Premature ovarian failure (HP:0008209)1.74814605
89Inability to walk (HP:0002540)1.73147226
90Chronic sinusitis (HP:0011109)1.73010967
91Sclerocornea (HP:0000647)1.72566526
92Abnormal number of erythroid precursors (HP:0012131)1.72401626
93Synostosis involving the elbow (HP:0003938)1.72225582
94Humeroradial synostosis (HP:0003041)1.72225582
95Aplasia/hypoplasia of the uterus (HP:0008684)1.70904109
96Abnormality of chromosome stability (HP:0003220)1.70776246
97Abnormality of the 1st metacarpal (HP:0010009)1.70161106
98Emotional lability (HP:0000712)1.69914578
99Absent thumb (HP:0009777)1.67503015
100Aplasia/Hypoplasia of the patella (HP:0006498)1.67229583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.41457164
2MST43.93974343
3STK163.86337958
4TSSK63.39836750
5VRK23.33168808
6EIF2AK13.25476898
7NME12.59514531
8EIF2AK32.53938417
9PBK2.51933023
10TAF12.47107015
11BUB12.29056668
12NEK12.25619482
13FRK2.18498662
14NUAK12.03114639
15TRIM281.90385083
16PASK1.89090775
17TLK11.78803524
18GRK11.76217337
19VRK11.71361247
20TXK1.70229400
21ADRBK21.67731003
22PLK41.65405768
23ZAK1.64192541
24PLK31.56724404
25WNK41.53524599
26ACVR1B1.45391042
27OXSR11.38667777
28BMPR1B1.35337977
29MAP4K21.31778344
30MKNK21.31664421
31PHKG11.25764888
32PHKG21.25764888
33CCNB11.23820188
34TGFBR11.20764515
35CDK191.18541018
36EIF2AK21.17953030
37WNK31.14555385
38STK391.09943184
39SRPK11.07610111
40DYRK20.98906254
41CDC70.97382706
42MKNK10.91439382
43RIPK40.90974995
44IKBKB0.88437690
45AKT30.86660899
46WEE10.86258231
47PLK10.85658983
48KIT0.85191831
49STK38L0.83345854
50DAPK10.82532564
51DAPK20.79746103
52INSRR0.76490779
53MAP3K140.74126286
54ALK0.68170733
55CSNK1G30.68023454
56CSNK1G20.66617597
57MAPKAPK30.65371525
58PLK20.61650935
59TTK0.58694197
60ATR0.55756211
61CSNK2A10.54617635
62TEC0.52076052
63PRKCG0.51851527
64MAPKAPK50.51847682
65NME20.51095240
66PRKCE0.51009355
67AURKB0.50248098
68CHEK20.49577173
69MAP4K10.49356289
70CSNK2A20.48082023
71RPS6KB20.47965079
72CSNK1A1L0.47465367
73PIK3CA0.47269555
74BRSK20.46492571
75TIE10.46259085
76TNK20.45558163
77CSNK1G10.45455568
78PRKCH0.40342809
79BCKDK0.39825468
80LYN0.38562695
81MYLK0.37829807
82STK40.36765922
83JAK30.35993079
84RPS6KA50.35052432
85CDK80.33371069
86TNIK0.32660452
87ITK0.31729922
88TYK20.31418081
89SYK0.31298622
90ATM0.31289663
91MAP3K120.31258116
92IGF1R0.28910131
93DAPK30.28893248
94OBSCN0.28027203
95IKBKE0.27839349
96PRKG10.27506054
97PRKCQ0.27111785
98ADRBK10.26973480
99PIK3CG0.26502141
100PRKACA0.26481594

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.35546923
2Ribosome_Homo sapiens_hsa030103.52545949
3Homologous recombination_Homo sapiens_hsa034403.35953468
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00829611
5Protein export_Homo sapiens_hsa030602.96225685
6Oxidative phosphorylation_Homo sapiens_hsa001902.93748267
7Asthma_Homo sapiens_hsa053102.79633642
8RNA polymerase_Homo sapiens_hsa030202.72092031
9Parkinsons disease_Homo sapiens_hsa050122.52439571
10DNA replication_Homo sapiens_hsa030302.42589063
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.24128180
12RNA degradation_Homo sapiens_hsa030182.10962901
13Mismatch repair_Homo sapiens_hsa034302.10639744
14Allograft rejection_Homo sapiens_hsa053301.93831513
15Autoimmune thyroid disease_Homo sapiens_hsa053201.89493358
16One carbon pool by folate_Homo sapiens_hsa006701.85854181
17Non-homologous end-joining_Homo sapiens_hsa034501.83310812
18Huntingtons disease_Homo sapiens_hsa050161.76150340
19Alzheimers disease_Homo sapiens_hsa050101.72744809
20Fanconi anemia pathway_Homo sapiens_hsa034601.71863526
21Nucleotide excision repair_Homo sapiens_hsa034201.70242792
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60256421
23Spliceosome_Homo sapiens_hsa030401.59276979
24Base excision repair_Homo sapiens_hsa034101.56090543
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54186595
26RNA transport_Homo sapiens_hsa030131.53360233
27Pyrimidine metabolism_Homo sapiens_hsa002401.53105388
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52849169
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52339312
30Basal transcription factors_Homo sapiens_hsa030221.45054633
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40960845
32Vitamin B6 metabolism_Homo sapiens_hsa007501.33291195
33Primary immunodeficiency_Homo sapiens_hsa053401.32283013
34Caffeine metabolism_Homo sapiens_hsa002321.31322872
35Linoleic acid metabolism_Homo sapiens_hsa005911.21902373
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21898871
37Tryptophan metabolism_Homo sapiens_hsa003801.21379517
38Purine metabolism_Homo sapiens_hsa002301.21127354
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15907663
40Type I diabetes mellitus_Homo sapiens_hsa049401.11805505
41Phototransduction_Homo sapiens_hsa047441.08111617
42Propanoate metabolism_Homo sapiens_hsa006401.04012331
43Sulfur metabolism_Homo sapiens_hsa009200.99416411
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97318887
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94832465
46Cardiac muscle contraction_Homo sapiens_hsa042600.94146150
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91516179
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.85529515
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85088408
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84158855
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81819621
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80095884
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.75761253
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74869617
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72615717
56Graft-versus-host disease_Homo sapiens_hsa053320.70110493
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.69274105
58Ether lipid metabolism_Homo sapiens_hsa005650.68951167
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68539560
60Pyruvate metabolism_Homo sapiens_hsa006200.68209106
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68094590
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67913537
63Peroxisome_Homo sapiens_hsa041460.64084782
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61208441
65Selenocompound metabolism_Homo sapiens_hsa004500.60263266
66Metabolic pathways_Homo sapiens_hsa011000.56973076
67Antigen processing and presentation_Homo sapiens_hsa046120.54993238
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.54880011
69Arachidonic acid metabolism_Homo sapiens_hsa005900.54822803
70Retinol metabolism_Homo sapiens_hsa008300.53479417
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45988729
72Hematopoietic cell lineage_Homo sapiens_hsa046400.43125012
73Nitrogen metabolism_Homo sapiens_hsa009100.42739683
74Chemical carcinogenesis_Homo sapiens_hsa052040.42736201
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.41142701
76Rheumatoid arthritis_Homo sapiens_hsa053230.40440889
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38873402
78Fat digestion and absorption_Homo sapiens_hsa049750.38407343
79Cell cycle_Homo sapiens_hsa041100.38139192
80Butanoate metabolism_Homo sapiens_hsa006500.37876816
81Systemic lupus erythematosus_Homo sapiens_hsa053220.36735173
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36319313
83Epstein-Barr virus infection_Homo sapiens_hsa051690.35300976
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34948757
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.34012222
86beta-Alanine metabolism_Homo sapiens_hsa004100.31458124
87mRNA surveillance pathway_Homo sapiens_hsa030150.31249128
88Taste transduction_Homo sapiens_hsa047420.30119446
89Tyrosine metabolism_Homo sapiens_hsa003500.29747013
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27907743
91Nicotine addiction_Homo sapiens_hsa050330.26503391
92Fatty acid elongation_Homo sapiens_hsa000620.25301107
93TGF-beta signaling pathway_Homo sapiens_hsa043500.24505366
94Olfactory transduction_Homo sapiens_hsa047400.22942262
95Fatty acid degradation_Homo sapiens_hsa000710.22420130
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20991309
97Vitamin digestion and absorption_Homo sapiens_hsa049770.20733291
98Morphine addiction_Homo sapiens_hsa050320.19197299
99Mineral absorption_Homo sapiens_hsa049780.19021090
100Folate biosynthesis_Homo sapiens_hsa007900.18150601

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