

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.55269905 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 5.06124755 |
| 3 | gonadal mesoderm development (GO:0007506) | 5.04145604 |
| 4 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.95376931 |
| 5 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.95376931 |
| 6 | proteasome assembly (GO:0043248) | 4.79339612 |
| 7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.66701633 |
| 8 | protein complex biogenesis (GO:0070271) | 4.51181941 |
| 9 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.39883986 |
| 10 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.36832910 |
| 11 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.31729688 |
| 12 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.17282250 |
| 13 | ATP synthesis coupled proton transport (GO:0015986) | 4.17066980 |
| 14 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.17066980 |
| 15 | regulation of chronic inflammatory response (GO:0002676) | 4.10389552 |
| 16 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.05971592 |
| 17 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.05971592 |
| 18 | NADH dehydrogenase complex assembly (GO:0010257) | 4.05971592 |
| 19 | maturation of SSU-rRNA (GO:0030490) | 4.03654663 |
| 20 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.93504185 |
| 21 | isotype switching (GO:0045190) | 3.93504185 |
| 22 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.93504185 |
| 23 | rRNA modification (GO:0000154) | 3.92957114 |
| 24 | cullin deneddylation (GO:0010388) | 3.90807503 |
| 25 | protein-cofactor linkage (GO:0018065) | 3.81471906 |
| 26 | maturation of 5.8S rRNA (GO:0000460) | 3.68302925 |
| 27 | protein deneddylation (GO:0000338) | 3.68257936 |
| 28 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.67478665 |
| 29 | termination of RNA polymerase III transcription (GO:0006386) | 3.60962897 |
| 30 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.60962897 |
| 31 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.54633661 |
| 32 | CENP-A containing nucleosome assembly (GO:0034080) | 3.53848712 |
| 33 | chromatin remodeling at centromere (GO:0031055) | 3.50647458 |
| 34 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.50623459 |
| 35 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.50172466 |
| 36 | ribosomal large subunit biogenesis (GO:0042273) | 3.45333264 |
| 37 | peptidyl-histidine modification (GO:0018202) | 3.44700347 |
| 38 | ribosomal small subunit assembly (GO:0000028) | 3.39204564 |
| 39 | rRNA processing (GO:0006364) | 3.37165242 |
| 40 | cellular component biogenesis (GO:0044085) | 3.35929258 |
| 41 | protein neddylation (GO:0045116) | 3.35910277 |
| 42 | termination of RNA polymerase I transcription (GO:0006363) | 3.35894429 |
| 43 | respiratory electron transport chain (GO:0022904) | 3.35774445 |
| 44 | rRNA methylation (GO:0031167) | 3.34506549 |
| 45 | rRNA metabolic process (GO:0016072) | 3.29723204 |
| 46 | electron transport chain (GO:0022900) | 3.29605654 |
| 47 | respiratory chain complex IV assembly (GO:0008535) | 3.27911171 |
| 48 | translation (GO:0006412) | 3.25881007 |
| 49 | DNA damage response, detection of DNA damage (GO:0042769) | 3.25477785 |
| 50 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.24960441 |
| 51 | cytochrome complex assembly (GO:0017004) | 3.24742016 |
| 52 | pseudouridine synthesis (GO:0001522) | 3.22794069 |
| 53 | tRNA processing (GO:0008033) | 3.18594562 |
| 54 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.18580108 |
| 55 | ribosome assembly (GO:0042255) | 3.16848822 |
| 56 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.15248704 |
| 57 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.08881883 |
| 58 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.08603733 |
| 59 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.08401250 |
| 60 | negative regulation of ligase activity (GO:0051352) | 3.08401250 |
| 61 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.06005450 |
| 62 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.05993363 |
| 63 | ribosome biogenesis (GO:0042254) | 3.05812176 |
| 64 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.04363689 |
| 65 | intracellular protein transmembrane import (GO:0044743) | 3.03816816 |
| 66 | RNA phosphodiester bond hydrolysis (GO:0090501) | 3.03069276 |
| 67 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.02244708 |
| 68 | kynurenine metabolic process (GO:0070189) | 3.01668289 |
| 69 | nucleobase biosynthetic process (GO:0046112) | 2.99998964 |
| 70 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.99411411 |
| 71 | histone exchange (GO:0043486) | 2.98702109 |
| 72 | tRNA metabolic process (GO:0006399) | 2.98309468 |
| 73 | RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502) | 2.96593184 |
| 74 | kinetochore assembly (GO:0051382) | 2.95537063 |
| 75 | regulation of immunoglobulin secretion (GO:0051023) | 2.94134062 |
| 76 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.93733100 |
| 77 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.93084553 |
| 78 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.93084553 |
| 79 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.93084553 |
| 80 | mismatch repair (GO:0006298) | 2.92695650 |
| 81 | rRNA catabolic process (GO:0016075) | 2.92289057 |
| 82 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.91327911 |
| 83 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.91225659 |
| 84 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.91225659 |
| 85 | aldehyde catabolic process (GO:0046185) | 2.91171799 |
| 86 | telomere maintenance via telomerase (GO:0007004) | 2.90161897 |
| 87 | GTP biosynthetic process (GO:0006183) | 2.88585728 |
| 88 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.87600172 |
| 89 | response to pheromone (GO:0019236) | 2.87378707 |
| 90 | replication fork processing (GO:0031297) | 2.86842606 |
| 91 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.86664263 |
| 92 | transcription from RNA polymerase I promoter (GO:0006360) | 2.86574042 |
| 93 | ncRNA processing (GO:0034470) | 2.85476588 |
| 94 | positive regulation of DNA recombination (GO:0045911) | 2.83473201 |
| 95 | viral transcription (GO:0019083) | 2.83390319 |
| 96 | ncRNA metabolic process (GO:0034660) | 2.82401426 |
| 97 | double-strand break repair via homologous recombination (GO:0000724) | 2.81916868 |
| 98 | ribosomal small subunit biogenesis (GO:0042274) | 2.81773941 |
| 99 | translational termination (GO:0006415) | 2.81032931 |
| 100 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.79977854 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.97050100 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.54792636 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.15540645 |
| 4 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.42025159 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.20268173 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.08252963 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.02827768 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.90748289 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.79987964 |
| 10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.67628605 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.62447101 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.60024530 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.57607449 |
| 14 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.57170895 |
| 15 | VDR_22108803_ChIP-Seq_LS180_Human | 2.45921275 |
| 16 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.42453383 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.42292415 |
| 18 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.38663316 |
| 19 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.35539054 |
| 20 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.32159043 |
| 21 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.30094431 |
| 22 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.26313127 |
| 23 | MYC_18940864_ChIP-ChIP_HL60_Human | 2.23076379 |
| 24 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.18005883 |
| 25 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.08200524 |
| 26 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.97448575 |
| 27 | FUS_26573619_Chip-Seq_HEK293_Human | 1.94861395 |
| 28 | EWS_26573619_Chip-Seq_HEK293_Human | 1.93305311 |
| 29 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.89108489 |
| 30 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.85452375 |
| 31 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.83124674 |
| 32 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.80179959 |
| 33 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.77909690 |
| 34 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.77783179 |
| 35 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.73943996 |
| 36 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.71364295 |
| 37 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.65595622 |
| 38 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.62395613 |
| 39 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.48291216 |
| 40 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.46737964 |
| 41 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.46495525 |
| 42 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.42380391 |
| 43 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.39579768 |
| 44 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.39119882 |
| 45 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.38942710 |
| 46 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.38552389 |
| 47 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.35502603 |
| 48 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.33187146 |
| 49 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.29439508 |
| 50 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.28678165 |
| 51 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.28204591 |
| 52 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.28029706 |
| 53 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.25868998 |
| 54 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.24389964 |
| 55 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.23634562 |
| 56 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.21116155 |
| 57 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.21024096 |
| 58 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.20200939 |
| 59 | GATA1_22025678_ChIP-Seq_K562_Human | 1.18620543 |
| 60 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.16549028 |
| 61 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.16199587 |
| 62 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.14853908 |
| 63 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.14853908 |
| 64 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.14019139 |
| 65 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.13465980 |
| 66 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.10094119 |
| 67 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.09610257 |
| 68 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.09504212 |
| 69 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.08185604 |
| 70 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.04971694 |
| 71 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.04158810 |
| 72 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.03883846 |
| 73 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.03322393 |
| 74 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.99227738 |
| 75 | GATA3_26560356_Chip-Seq_TH2_Human | 0.99143664 |
| 76 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.98046061 |
| 77 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.97050983 |
| 78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.96786707 |
| 79 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.96506865 |
| 80 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.96506865 |
| 81 | P300_19829295_ChIP-Seq_ESCs_Human | 0.94845861 |
| 82 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.94655033 |
| 83 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.92761631 |
| 84 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.92204796 |
| 85 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.92204796 |
| 86 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.92126538 |
| 87 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.90391078 |
| 88 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.88391063 |
| 89 | AR_20517297_ChIP-Seq_VCAP_Human | 0.87741928 |
| 90 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.87602533 |
| 91 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87249776 |
| 92 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.85890038 |
| 93 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.85239405 |
| 94 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.85225374 |
| 95 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.84940675 |
| 96 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.84530389 |
| 97 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.83920060 |
| 98 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.83671180 |
| 99 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.82960964 |
| 100 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.82773026 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 3.24313420 |
| 2 | MP0005075_abnormal_melanosome_morpholog | 2.95021111 |
| 3 | MP0010094_abnormal_chromosome_stability | 2.93087111 |
| 4 | MP0008877_abnormal_DNA_methylation | 2.79284207 |
| 5 | MP0008058_abnormal_DNA_repair | 2.78577807 |
| 6 | MP0003195_calcinosis | 2.76925529 |
| 7 | MP0000685_abnormal_immune_system | 2.63557892 |
| 8 | MP0001835_abnormal_antigen_presentation | 2.63352382 |
| 9 | MP0002837_dystrophic_cardiac_calcinosis | 2.56964691 |
| 10 | MP0008875_abnormal_xenobiotic_pharmacok | 2.44709791 |
| 11 | MP0003252_abnormal_bile_duct | 2.28469062 |
| 12 | MP0003786_premature_aging | 2.21403687 |
| 13 | MP0005646_abnormal_pituitary_gland | 2.18148932 |
| 14 | MP0003718_maternal_effect | 2.13733616 |
| 15 | MP0005671_abnormal_response_to | 2.09388749 |
| 16 | MP0001348_abnormal_lacrimal_gland | 2.08067905 |
| 17 | MP0002735_abnormal_chemical_nociception | 1.98563491 |
| 18 | MP0008872_abnormal_physiological_respon | 1.94049392 |
| 19 | MP0000372_irregular_coat_pigmentation | 1.93240866 |
| 20 | MP0002396_abnormal_hematopoietic_system | 1.89055040 |
| 21 | MP0003567_abnormal_fetal_cardiomyocyte | 1.88191060 |
| 22 | MP0006036_abnormal_mitochondrial_physio | 1.82051116 |
| 23 | MP0002736_abnormal_nociception_after | 1.81663804 |
| 24 | MP0004147_increased_porphyrin_level | 1.81596543 |
| 25 | MP0004957_abnormal_blastocyst_morpholog | 1.79271020 |
| 26 | MP0001873_stomach_inflammation | 1.78114128 |
| 27 | MP0001188_hyperpigmentation | 1.74770855 |
| 28 | MP0002160_abnormal_reproductive_system | 1.67300789 |
| 29 | MP0001501_abnormal_sleep_pattern | 1.61964673 |
| 30 | MP0004145_abnormal_muscle_electrophysio | 1.58647386 |
| 31 | MP0005084_abnormal_gallbladder_morpholo | 1.58341856 |
| 32 | MP0004043_abnormal_pH_regulation | 1.57474448 |
| 33 | MP0008007_abnormal_cellular_replicative | 1.55946939 |
| 34 | MP0006072_abnormal_retinal_apoptosis | 1.53079364 |
| 35 | MP0008057_abnormal_DNA_replication | 1.52096785 |
| 36 | MP0005377_hearing/vestibular/ear_phenot | 1.50823715 |
| 37 | MP0003878_abnormal_ear_physiology | 1.50823715 |
| 38 | MP0004381_abnormal_hair_follicle | 1.48952365 |
| 39 | MP0001727_abnormal_embryo_implantation | 1.47080238 |
| 40 | MP0008995_early_reproductive_senescence | 1.46903144 |
| 41 | MP0003011_delayed_dark_adaptation | 1.45175293 |
| 42 | MP0001968_abnormal_touch/_nociception | 1.40819880 |
| 43 | MP0004019_abnormal_vitamin_homeostasis | 1.37059745 |
| 44 | MP0003283_abnormal_digestive_organ | 1.35112559 |
| 45 | MP0003787_abnormal_imprinting | 1.33004610 |
| 46 | MP0001800_abnormal_humoral_immune | 1.29638221 |
| 47 | MP0004215_abnormal_myocardial_fiber | 1.26895919 |
| 48 | MP0001764_abnormal_homeostasis | 1.25641313 |
| 49 | MP0009379_abnormal_foot_pigmentation | 1.24484826 |
| 50 | MP0002166_altered_tumor_susceptibility | 1.23664523 |
| 51 | MP0009764_decreased_sensitivity_to | 1.23294177 |
| 52 | MP0002163_abnormal_gland_morphology | 1.22950784 |
| 53 | MP0002006_tumorigenesis | 1.22878753 |
| 54 | MP0003077_abnormal_cell_cycle | 1.20136611 |
| 55 | MP0005389_reproductive_system_phenotype | 1.19967230 |
| 56 | MP0005387_immune_system_phenotype | 1.18638397 |
| 57 | MP0001790_abnormal_immune_system | 1.18638397 |
| 58 | MP0003693_abnormal_embryo_hatching | 1.17330524 |
| 59 | MP0002148_abnormal_hypersensitivity_rea | 1.17194707 |
| 60 | MP0005645_abnormal_hypothalamus_physiol | 1.17174177 |
| 61 | MP0005085_abnormal_gallbladder_physiolo | 1.16797859 |
| 62 | MP0003111_abnormal_nucleus_morphology | 1.12177456 |
| 63 | MP0003646_muscle_fatigue | 1.11522037 |
| 64 | MP0005174_abnormal_tail_pigmentation | 1.06932449 |
| 65 | MP0009785_altered_susceptibility_to | 1.01040234 |
| 66 | MP0009765_abnormal_xenobiotic_induced | 1.00022704 |
| 67 | MP0004885_abnormal_endolymph | 0.99854015 |
| 68 | MP0006035_abnormal_mitochondrial_morpho | 0.98134377 |
| 69 | MP0002277_abnormal_respiratory_mucosa | 0.95665735 |
| 70 | MP0009745_abnormal_behavioral_response | 0.93098841 |
| 71 | MP0000371_diluted_coat_color | 0.92997479 |
| 72 | MP0002095_abnormal_skin_pigmentation | 0.92699058 |
| 73 | MP0002138_abnormal_hepatobiliary_system | 0.92202302 |
| 74 | MP0002234_abnormal_pharynx_morphology | 0.90723665 |
| 75 | MP0009697_abnormal_copulation | 0.90422526 |
| 76 | MP0002102_abnormal_ear_morphology | 0.89875568 |
| 77 | MP0005253_abnormal_eye_physiology | 0.88530334 |
| 78 | MP0001986_abnormal_taste_sensitivity | 0.86983704 |
| 79 | MP0005551_abnormal_eye_electrophysiolog | 0.86620892 |
| 80 | MP0003137_abnormal_impulse_conducting | 0.86385722 |
| 81 | MP0005379_endocrine/exocrine_gland_phen | 0.85092400 |
| 82 | MP0000427_abnormal_hair_cycle | 0.84378245 |
| 83 | MP0002928_abnormal_bile_duct | 0.83464408 |
| 84 | MP0010386_abnormal_urinary_bladder | 0.83153656 |
| 85 | MP0005266_abnormal_metabolism | 0.80399524 |
| 86 | MP0009046_muscle_twitch | 0.80045813 |
| 87 | MP0008873_increased_physiological_sensi | 0.79501561 |
| 88 | MP0006082_CNS_inflammation | 0.77901563 |
| 89 | MP0003866_abnormal_defecation | 0.77552577 |
| 90 | MP0008932_abnormal_embryonic_tissue | 0.77119070 |
| 91 | MP0003186_abnormal_redox_activity | 0.77064087 |
| 92 | MP0005636_abnormal_mineral_homeostasis | 0.75645072 |
| 93 | MP0002272_abnormal_nervous_system | 0.75346084 |
| 94 | MP0001756_abnormal_urination | 0.74162531 |
| 95 | MP0001529_abnormal_vocalization | 0.72624322 |
| 96 | MP0005165_increased_susceptibility_to | 0.70340047 |
| 97 | MP0005367_renal/urinary_system_phenotyp | 0.69179963 |
| 98 | MP0000516_abnormal_urinary_system | 0.69179963 |
| 99 | MP0006292_abnormal_olfactory_placode | 0.68419797 |
| 100 | MP0008775_abnormal_heart_ventricle | 0.68071939 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.23063248 |
| 2 | Acute encephalopathy (HP:0006846) | 4.64100669 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.51208448 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.49912539 |
| 5 | Increased CSF lactate (HP:0002490) | 4.48917395 |
| 6 | Progressive macrocephaly (HP:0004481) | 4.35687681 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 3.85448363 |
| 8 | Lipid accumulation in hepatocytes (HP:0006561) | 3.68373774 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.52936648 |
| 10 | 3-Methylglutaconic aciduria (HP:0003535) | 3.37339239 |
| 11 | Chronic hepatic failure (HP:0100626) | 3.29424208 |
| 12 | Pancreatic cysts (HP:0001737) | 3.21795900 |
| 13 | Hepatic necrosis (HP:0002605) | 3.14096883 |
| 14 | Congenital, generalized hypertrichosis (HP:0004540) | 3.10231762 |
| 15 | Cerebral edema (HP:0002181) | 2.95809875 |
| 16 | Exertional dyspnea (HP:0002875) | 2.93024910 |
| 17 | IgG deficiency (HP:0004315) | 2.92556637 |
| 18 | Increased serum lactate (HP:0002151) | 2.91560753 |
| 19 | Stomatitis (HP:0010280) | 2.85403852 |
| 20 | Colon cancer (HP:0003003) | 2.84224552 |
| 21 | Leukodystrophy (HP:0002415) | 2.81580505 |
| 22 | Renal Fanconi syndrome (HP:0001994) | 2.78988327 |
| 23 | Delayed CNS myelination (HP:0002188) | 2.77298857 |
| 24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.75993390 |
| 25 | Pancreatic fibrosis (HP:0100732) | 2.72790006 |
| 26 | Optic disc pallor (HP:0000543) | 2.70935176 |
| 27 | Bile duct proliferation (HP:0001408) | 2.68797852 |
| 28 | Abnormal biliary tract physiology (HP:0012439) | 2.68797852 |
| 29 | Sensory axonal neuropathy (HP:0003390) | 2.64661990 |
| 30 | Lactic acidosis (HP:0003128) | 2.63616369 |
| 31 | Respiratory failure (HP:0002878) | 2.60546315 |
| 32 | Abnormality of renal resorption (HP:0011038) | 2.55456003 |
| 33 | Adactyly (HP:0009776) | 2.53681705 |
| 34 | Abnormality of T cell physiology (HP:0011840) | 2.53353827 |
| 35 | Congenital stationary night blindness (HP:0007642) | 2.47752636 |
| 36 | True hermaphroditism (HP:0010459) | 2.45746398 |
| 37 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 2.41710401 |
| 38 | Aplastic anemia (HP:0001915) | 2.40432567 |
| 39 | Pendular nystagmus (HP:0012043) | 2.37179562 |
| 40 | Progressive microcephaly (HP:0000253) | 2.35787728 |
| 41 | Abnormality of the renal cortex (HP:0011035) | 2.30995757 |
| 42 | Nephronophthisis (HP:0000090) | 2.30398973 |
| 43 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.24305664 |
| 44 | Asplenia (HP:0001746) | 2.23667315 |
| 45 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.20830499 |
| 46 | Meckel diverticulum (HP:0002245) | 2.19810337 |
| 47 | Paralysis (HP:0003470) | 2.18402605 |
| 48 | Birth length less than 3rd percentile (HP:0003561) | 2.15005296 |
| 49 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.13060517 |
| 50 | Hypoplasia of the pons (HP:0012110) | 2.12946841 |
| 51 | Supernumerary spleens (HP:0009799) | 2.12595857 |
| 52 | Enlarged epiphyses (HP:0010580) | 2.12243176 |
| 53 | Lethargy (HP:0001254) | 2.10266053 |
| 54 | Exercise intolerance (HP:0003546) | 2.09269654 |
| 55 | Abolished electroretinogram (ERG) (HP:0000550) | 2.07359828 |
| 56 | Abnormality of the ileum (HP:0001549) | 2.04336123 |
| 57 | Fibular aplasia (HP:0002990) | 2.03237412 |
| 58 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.01033710 |
| 59 | Abnormality of the preputium (HP:0100587) | 2.00542805 |
| 60 | Hyperglycinemia (HP:0002154) | 2.00198224 |
| 61 | Type I transferrin isoform profile (HP:0003642) | 1.99843753 |
| 62 | Abnormality of the renal medulla (HP:0100957) | 1.99402809 |
| 63 | Pancytopenia (HP:0001876) | 1.98750682 |
| 64 | Severe combined immunodeficiency (HP:0004430) | 1.98488911 |
| 65 | Abnormality of the pons (HP:0007361) | 1.97373794 |
| 66 | CNS demyelination (HP:0007305) | 1.96825924 |
| 67 | Clubbing of toes (HP:0100760) | 1.95294335 |
| 68 | Increased IgM level (HP:0003496) | 1.94135674 |
| 69 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 1.91673832 |
| 70 | Short 1st metacarpal (HP:0010034) | 1.91673832 |
| 71 | Renal cortical cysts (HP:0000803) | 1.91531669 |
| 72 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.90667408 |
| 73 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 1.89491176 |
| 74 | Increased intramyocellular lipid droplets (HP:0012240) | 1.88476439 |
| 75 | Abnormality of alanine metabolism (HP:0010916) | 1.82951704 |
| 76 | Hyperalaninemia (HP:0003348) | 1.82951704 |
| 77 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.82951704 |
| 78 | Blindness (HP:0000618) | 1.81879487 |
| 79 | Abnormality of T cells (HP:0002843) | 1.81702507 |
| 80 | Molar tooth sign on MRI (HP:0002419) | 1.81648872 |
| 81 | Abnormality of midbrain morphology (HP:0002418) | 1.81648872 |
| 82 | Poor head control (HP:0002421) | 1.80150752 |
| 83 | Male pseudohermaphroditism (HP:0000037) | 1.78555654 |
| 84 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 1.77781395 |
| 85 | Macrocytic anemia (HP:0001972) | 1.77004190 |
| 86 | Cleft eyelid (HP:0000625) | 1.76368149 |
| 87 | Type II lissencephaly (HP:0007260) | 1.75127114 |
| 88 | Premature ovarian failure (HP:0008209) | 1.74814605 |
| 89 | Inability to walk (HP:0002540) | 1.73147226 |
| 90 | Chronic sinusitis (HP:0011109) | 1.73010967 |
| 91 | Sclerocornea (HP:0000647) | 1.72566526 |
| 92 | Abnormal number of erythroid precursors (HP:0012131) | 1.72401626 |
| 93 | Synostosis involving the elbow (HP:0003938) | 1.72225582 |
| 94 | Humeroradial synostosis (HP:0003041) | 1.72225582 |
| 95 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.70904109 |
| 96 | Abnormality of chromosome stability (HP:0003220) | 1.70776246 |
| 97 | Abnormality of the 1st metacarpal (HP:0010009) | 1.70161106 |
| 98 | Emotional lability (HP:0000712) | 1.69914578 |
| 99 | Absent thumb (HP:0009777) | 1.67503015 |
| 100 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.67229583 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TAOK3 | 4.41457164 |
| 2 | MST4 | 3.93974343 |
| 3 | STK16 | 3.86337958 |
| 4 | TSSK6 | 3.39836750 |
| 5 | VRK2 | 3.33168808 |
| 6 | EIF2AK1 | 3.25476898 |
| 7 | NME1 | 2.59514531 |
| 8 | EIF2AK3 | 2.53938417 |
| 9 | PBK | 2.51933023 |
| 10 | TAF1 | 2.47107015 |
| 11 | BUB1 | 2.29056668 |
| 12 | NEK1 | 2.25619482 |
| 13 | FRK | 2.18498662 |
| 14 | NUAK1 | 2.03114639 |
| 15 | TRIM28 | 1.90385083 |
| 16 | PASK | 1.89090775 |
| 17 | TLK1 | 1.78803524 |
| 18 | GRK1 | 1.76217337 |
| 19 | VRK1 | 1.71361247 |
| 20 | TXK | 1.70229400 |
| 21 | ADRBK2 | 1.67731003 |
| 22 | PLK4 | 1.65405768 |
| 23 | ZAK | 1.64192541 |
| 24 | PLK3 | 1.56724404 |
| 25 | WNK4 | 1.53524599 |
| 26 | ACVR1B | 1.45391042 |
| 27 | OXSR1 | 1.38667777 |
| 28 | BMPR1B | 1.35337977 |
| 29 | MAP4K2 | 1.31778344 |
| 30 | MKNK2 | 1.31664421 |
| 31 | PHKG1 | 1.25764888 |
| 32 | PHKG2 | 1.25764888 |
| 33 | CCNB1 | 1.23820188 |
| 34 | TGFBR1 | 1.20764515 |
| 35 | CDK19 | 1.18541018 |
| 36 | EIF2AK2 | 1.17953030 |
| 37 | WNK3 | 1.14555385 |
| 38 | STK39 | 1.09943184 |
| 39 | SRPK1 | 1.07610111 |
| 40 | DYRK2 | 0.98906254 |
| 41 | CDC7 | 0.97382706 |
| 42 | MKNK1 | 0.91439382 |
| 43 | RIPK4 | 0.90974995 |
| 44 | IKBKB | 0.88437690 |
| 45 | AKT3 | 0.86660899 |
| 46 | WEE1 | 0.86258231 |
| 47 | PLK1 | 0.85658983 |
| 48 | KIT | 0.85191831 |
| 49 | STK38L | 0.83345854 |
| 50 | DAPK1 | 0.82532564 |
| 51 | DAPK2 | 0.79746103 |
| 52 | INSRR | 0.76490779 |
| 53 | MAP3K14 | 0.74126286 |
| 54 | ALK | 0.68170733 |
| 55 | CSNK1G3 | 0.68023454 |
| 56 | CSNK1G2 | 0.66617597 |
| 57 | MAPKAPK3 | 0.65371525 |
| 58 | PLK2 | 0.61650935 |
| 59 | TTK | 0.58694197 |
| 60 | ATR | 0.55756211 |
| 61 | CSNK2A1 | 0.54617635 |
| 62 | TEC | 0.52076052 |
| 63 | PRKCG | 0.51851527 |
| 64 | MAPKAPK5 | 0.51847682 |
| 65 | NME2 | 0.51095240 |
| 66 | PRKCE | 0.51009355 |
| 67 | AURKB | 0.50248098 |
| 68 | CHEK2 | 0.49577173 |
| 69 | MAP4K1 | 0.49356289 |
| 70 | CSNK2A2 | 0.48082023 |
| 71 | RPS6KB2 | 0.47965079 |
| 72 | CSNK1A1L | 0.47465367 |
| 73 | PIK3CA | 0.47269555 |
| 74 | BRSK2 | 0.46492571 |
| 75 | TIE1 | 0.46259085 |
| 76 | TNK2 | 0.45558163 |
| 77 | CSNK1G1 | 0.45455568 |
| 78 | PRKCH | 0.40342809 |
| 79 | BCKDK | 0.39825468 |
| 80 | LYN | 0.38562695 |
| 81 | MYLK | 0.37829807 |
| 82 | STK4 | 0.36765922 |
| 83 | JAK3 | 0.35993079 |
| 84 | RPS6KA5 | 0.35052432 |
| 85 | CDK8 | 0.33371069 |
| 86 | TNIK | 0.32660452 |
| 87 | ITK | 0.31729922 |
| 88 | TYK2 | 0.31418081 |
| 89 | SYK | 0.31298622 |
| 90 | ATM | 0.31289663 |
| 91 | MAP3K12 | 0.31258116 |
| 92 | IGF1R | 0.28910131 |
| 93 | DAPK3 | 0.28893248 |
| 94 | OBSCN | 0.28027203 |
| 95 | IKBKE | 0.27839349 |
| 96 | PRKG1 | 0.27506054 |
| 97 | PRKCQ | 0.27111785 |
| 98 | ADRBK1 | 0.26973480 |
| 99 | PIK3CG | 0.26502141 |
| 100 | PRKACA | 0.26481594 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.35546923 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 3.52545949 |
| 3 | Homologous recombination_Homo sapiens_hsa03440 | 3.35953468 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.00829611 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.96225685 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.93748267 |
| 7 | Asthma_Homo sapiens_hsa05310 | 2.79633642 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.72092031 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.52439571 |
| 10 | DNA replication_Homo sapiens_hsa03030 | 2.42589063 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.24128180 |
| 12 | RNA degradation_Homo sapiens_hsa03018 | 2.10962901 |
| 13 | Mismatch repair_Homo sapiens_hsa03430 | 2.10639744 |
| 14 | Allograft rejection_Homo sapiens_hsa05330 | 1.93831513 |
| 15 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.89493358 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.85854181 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.83310812 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.76150340 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.72744809 |
| 20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.71863526 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.70242792 |
| 22 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.60256421 |
| 23 | Spliceosome_Homo sapiens_hsa03040 | 1.59276979 |
| 24 | Base excision repair_Homo sapiens_hsa03410 | 1.56090543 |
| 25 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.54186595 |
| 26 | RNA transport_Homo sapiens_hsa03013 | 1.53360233 |
| 27 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.53105388 |
| 28 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.52849169 |
| 29 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.52339312 |
| 30 | Basal transcription factors_Homo sapiens_hsa03022 | 1.45054633 |
| 31 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.40960845 |
| 32 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.33291195 |
| 33 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.32283013 |
| 34 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.31322872 |
| 35 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.21902373 |
| 36 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.21898871 |
| 37 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.21379517 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.21127354 |
| 39 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.15907663 |
| 40 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.11805505 |
| 41 | Phototransduction_Homo sapiens_hsa04744 | 1.08111617 |
| 42 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.04012331 |
| 43 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.99416411 |
| 44 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.97318887 |
| 45 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.94832465 |
| 46 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.94146150 |
| 47 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.91516179 |
| 48 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.85529515 |
| 49 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.85088408 |
| 50 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.84158855 |
| 51 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.81819621 |
| 52 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.80095884 |
| 53 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.75761253 |
| 54 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.74869617 |
| 55 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.72615717 |
| 56 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.70110493 |
| 57 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.69274105 |
| 58 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.68951167 |
| 59 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.68539560 |
| 60 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.68209106 |
| 61 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.68094590 |
| 62 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.67913537 |
| 63 | Peroxisome_Homo sapiens_hsa04146 | 0.64084782 |
| 64 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.61208441 |
| 65 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.60263266 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.56973076 |
| 67 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.54993238 |
| 68 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.54880011 |
| 69 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.54822803 |
| 70 | Retinol metabolism_Homo sapiens_hsa00830 | 0.53479417 |
| 71 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.45988729 |
| 72 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.43125012 |
| 73 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.42739683 |
| 74 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.42736201 |
| 75 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.41142701 |
| 76 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.40440889 |
| 77 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.38873402 |
| 78 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.38407343 |
| 79 | Cell cycle_Homo sapiens_hsa04110 | 0.38139192 |
| 80 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.37876816 |
| 81 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.36735173 |
| 82 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.36319313 |
| 83 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.35300976 |
| 84 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.34948757 |
| 85 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.34012222 |
| 86 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.31458124 |
| 87 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.31249128 |
| 88 | Taste transduction_Homo sapiens_hsa04742 | 0.30119446 |
| 89 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.29747013 |
| 90 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27907743 |
| 91 | Nicotine addiction_Homo sapiens_hsa05033 | 0.26503391 |
| 92 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.25301107 |
| 93 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.24505366 |
| 94 | Olfactory transduction_Homo sapiens_hsa04740 | 0.22942262 |
| 95 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.22420130 |
| 96 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.20991309 |
| 97 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.20733291 |
| 98 | Morphine addiction_Homo sapiens_hsa05032 | 0.19197299 |
| 99 | Mineral absorption_Homo sapiens_hsa04978 | 0.19021090 |
| 100 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.18150601 |

