ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	7.12607550
2	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	6.24616223
3	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	5.76933276
4	membrane repolarization during action potential (GO:0086011)	5.27407432
5	parturition (GO:0007567)	5.05294270
6	cell proliferation in forebrain (GO:0021846)	4.42459383
7	serotonin metabolic process (GO:0042428)	4.26181601
8	regulation of DNA endoreduplication (GO:0032875)	4.24718395
9	membrane repolarization (GO:0086009)	4.15440566
10	positive regulation of synapse maturation (GO:0090129)	3.92354845
11	primary amino compound metabolic process (GO:1901160)	3.87936159
12	pyrimidine nucleobase catabolic process (GO:0006208)	3.83093144
13	regulation of membrane repolarization (GO:0060306)	3.77455487
14	regulation of synapse maturation (GO:0090128)	3.56095477
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.53204023
16	negative regulation of response to food (GO:0032096)	3.52794590
17	negative regulation of appetite (GO:0032099)	3.52794590
18	substrate-independent telencephalic tangential migration (GO:0021826)	3.48859502
19	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.48859502
20	cellular response to electrical stimulus (GO:0071257)	3.43345883
21	protein polyglutamylation (GO:0018095)	3.41806858
22	vitamin A metabolic process (GO:0006776)	3.41185817
23	gamma-aminobutyric acid transport (GO:0015812)	3.36600808
24	forebrain neuron differentiation (GO:0021879)	3.33467486
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.32167113
26	NADH dehydrogenase complex assembly (GO:0010257)	3.32167113
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.32167113
28	transmission of nerve impulse (GO:0019226)	3.25261040
29	regulation of potassium ion transmembrane transport (GO:1901379)	3.24316646
30	retinal ganglion cell axon guidance (GO:0031290)	3.23792580
31	glyoxylate metabolic process (GO:0046487)	3.21158816
32	epithelial cilium movement (GO:0003351)	3.20493442
33	membrane depolarization during action potential (GO:0086010)	3.17888884
34	protein complex biogenesis (GO:0070271)	3.15765520
35	cerebellar Purkinje cell differentiation (GO:0021702)	3.14593841
36	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.11562371
37	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.10321400
38	cellular anion homeostasis (GO:0030002)	3.05332675
39	neurofilament cytoskeleton organization (GO:0060052)	3.05067595
40	ovulation cycle (GO:0042698)	3.04971088
41	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.03405143
42	spinal cord association neuron differentiation (GO:0021527)	3.00556310
43	behavioral fear response (GO:0001662)	3.00437282
44	behavioral defense response (GO:0002209)	3.00437282
45	dendritic spine morphogenesis (GO:0060997)	3.00344278
46	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.99895910
47	nucleobase catabolic process (GO:0046113)	2.97064318
48	nonmotile primary cilium assembly (GO:0035058)	2.96302657
49	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.89025617
50	spinal cord development (GO:0021510)	2.88196469
51	fear response (GO:0042596)	2.86914571
52	vitamin catabolic process (GO:0009111)	2.86584819
53	fat-soluble vitamin catabolic process (GO:0042363)	2.86584819
54	synaptic transmission, cholinergic (GO:0007271)	2.84887562
55	protein localization to synapse (GO:0035418)	2.84082653
56	regulation of mesoderm development (GO:2000380)	2.83381539
57	viral transcription (GO:0019083)	2.81225303
58	locomotory exploration behavior (GO:0035641)	2.76484326
59	postsynaptic membrane organization (GO:0001941)	2.76369794
60	indolalkylamine metabolic process (GO:0006586)	2.76087517
61	short-term memory (GO:0007614)	2.73520173
62	translational termination (GO:0006415)	2.70749567
63	mitochondrial respiratory chain complex assembly (GO:0033108)	2.70544501
64	negative regulation of systemic arterial blood pressure (GO:0003085)	2.69155240
65	indole-containing compound metabolic process (GO:0042430)	2.68914133
66	head development (GO:0060322)	2.68251473
67	behavioral response to ethanol (GO:0048149)	2.67649093
68	cellular potassium ion homeostasis (GO:0030007)	2.66906006
69	cardiovascular system development (GO:0072358)	2.66229262
70	outer ear morphogenesis (GO:0042473)	2.65624111
71	somite development (GO:0061053)	2.62581383
72	exploration behavior (GO:0035640)	2.60990596
73	regulation of heart rate by cardiac conduction (GO:0086091)	2.60870377
74	multicellular organismal signaling (GO:0035637)	2.59460095
75	regulation of potassium ion transport (GO:0043266)	2.59390411
76	oxidative demethylation (GO:0070989)	2.59285177
77	neuron recognition (GO:0008038)	2.58288028
78	presynaptic membrane organization (GO:0097090)	2.56213415
79	cilium movement (GO:0003341)	2.54360201
80	chaperone-mediated protein transport (GO:0072321)	2.54007925
81	synapse assembly (GO:0007416)	2.53993340
82	endoderm formation (GO:0001706)	2.53684532
83	positive regulation of action potential (GO:0045760)	2.51628068
84	auditory behavior (GO:0031223)	2.51302319
85	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.51268925
86	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.50167059
87	camera-type eye morphogenesis (GO:0048593)	2.50031988
88	magnesium ion transport (GO:0015693)	2.48942473
89	axon ensheathment in central nervous system (GO:0032291)	2.48067562
90	central nervous system myelination (GO:0022010)	2.48067562
91	regulation of response to food (GO:0032095)	2.47771781
92	interkinetic nuclear migration (GO:0022027)	2.45702364
93	axonal fasciculation (GO:0007413)	2.45067309
94	regulation of action potential (GO:0098900)	2.44448532
95	cell differentiation in hindbrain (GO:0021533)	2.44338472
96	neuron maturation (GO:0042551)	2.43808524
97	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.42345075
98	trivalent inorganic anion homeostasis (GO:0072506)	2.42267101
99	phosphate ion homeostasis (GO:0055062)	2.42267101
100	positive regulation of gastrulation (GO:2000543)	2.41822657

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.97924061
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.30887333
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.89406122
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.72695992
5	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.67203745
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.59739703
7	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.51057496
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.49912488
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.45368341
10	REST_21632747_ChIP-Seq_MESCs_Mouse	2.40830525
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.35218753
12	VDR_22108803_ChIP-Seq_LS180_Human	2.29579162
13	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.26635637
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.20768287
15	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.20020668
16	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.15699611
17	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.13246972
18	IRF1_19129219_ChIP-ChIP_H3396_Human	2.11844834
19	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.04779993
20	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.04779993
21	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.02790169
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98363381
23	RNF2_27304074_Chip-Seq_NSC_Mouse	1.98352244
24	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.97339619
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.97268693
26	ZNF274_21170338_ChIP-Seq_K562_Hela	1.93647327
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.92845611
28	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.83976827
29	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.82992509
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.80681100
31	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.78941260
32	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.76226250
33	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.72749834
34	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.68921047
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67038972
36	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.55938212
37	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.53249923
38	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.52518094
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.51898871
40	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.46978090
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46573811
42	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.41240516
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40985845
44	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.38934034
45	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.36965609
46	TAF15_26573619_Chip-Seq_HEK293_Human	1.35160047
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31987662
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31987662
49	P300_19829295_ChIP-Seq_ESCs_Human	1.30980983
50	EWS_26573619_Chip-Seq_HEK293_Human	1.30763205
51	DROSHA_22980978_ChIP-Seq_HELA_Human	1.29937635
52	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.24476491
53	IGF1R_20145208_ChIP-Seq_DFB_Human	1.20739836
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.20206224
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.18578836
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17769015
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17437591
58	AR_21572438_ChIP-Seq_LNCaP_Human	1.15678940
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14740758
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.13895842
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.13760423
62	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12239260
63	FUS_26573619_Chip-Seq_HEK293_Human	1.11771201
64	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11426158
65	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10430563
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09876015
67	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.07629337
68	AR_25329375_ChIP-Seq_VCAP_Human	1.07467595
69	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06937697
70	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06920097
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06806735
72	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.06674399
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06530020
74	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04713467
75	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.04376833
76	STAT3_23295773_ChIP-Seq_U87_Human	1.02739199
77	TCF4_23295773_ChIP-Seq_U87_Human	1.02619276
78	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02058305
79	CBP_20019798_ChIP-Seq_JUKART_Human	1.02058305
80	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.01422829
81	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.01192040
82	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.00772839
83	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.00522919
84	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00372436
85	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00198581
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98038577
87	NCOR_22424771_ChIP-Seq_293T_Human	0.96404171
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96024784
89	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.95964785
90	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.95680162
91	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.95036612
92	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94780957
93	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94709578
94	BCAT_22108803_ChIP-Seq_LS180_Human	0.94293314
95	ER_23166858_ChIP-Seq_MCF-7_Human	0.94236872
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93707879
97	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.89697424
98	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89675026
99	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.89448092
100	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.88032422

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.50788245
2	MP0003787_abnormal_imprinting	2.93817195
3	MP0009379_abnormal_foot_pigmentation	2.81355049
4	MP0003646_muscle_fatigue	2.49817547
5	MP0003123_paternal_imprinting	2.38086229
6	MP0005423_abnormal_somatic_nervous	2.29191454
7	MP0002837_dystrophic_cardiac_calcinosis	2.17945827
8	MP0003880_abnormal_central_pattern	2.15691515
9	MP0001440_abnormal_grooming_behavior	2.12948673
10	MP0003879_abnormal_hair_cell	2.09876654
11	MP0001485_abnormal_pinna_reflex	2.08252963
12	MP0008877_abnormal_DNA_methylation	2.06837122
13	MP0002160_abnormal_reproductive_system	2.06044577
14	MP0000778_abnormal_nervous_system	2.05525424
15	MP0002653_abnormal_ependyma_morphology	2.05190619
16	MP0006276_abnormal_autonomic_nervous	2.03860242
17	MP0004885_abnormal_endolymph	1.97042869
18	MP0002272_abnormal_nervous_system	1.95985473
19	MP0009745_abnormal_behavioral_response	1.89632847
20	MP0000569_abnormal_digit_pigmentation	1.88028099
21	MP0003121_genomic_imprinting	1.83507594
22	MP0003122_maternal_imprinting	1.82686600
23	MP0002822_catalepsy	1.80520955
24	MP0000631_abnormal_neuroendocrine_gland	1.69875652
25	MP0005646_abnormal_pituitary_gland	1.66482469
26	MP0005551_abnormal_eye_electrophysiolog	1.65350537
27	MP0004742_abnormal_vestibular_system	1.62494914
28	MP0004133_heterotaxia	1.62421594
29	MP0003635_abnormal_synaptic_transmissio	1.62275210
30	MP0002733_abnormal_thermal_nociception	1.59955239
31	MP0002184_abnormal_innervation	1.59776272
32	MP0004145_abnormal_muscle_electrophysio	1.57770528
33	MP0005389_reproductive_system_phenotype	1.56880166
34	MP0002638_abnormal_pupillary_reflex	1.56776217
35	MP0002876_abnormal_thyroid_physiology	1.52864242
36	MP0001188_hyperpigmentation	1.52860463
37	MP0004130_abnormal_muscle_cell	1.52829176
38	MP0002163_abnormal_gland_morphology	1.52277541
39	MP0003890_abnormal_embryonic-extraembry	1.50437974
40	MP0003942_abnormal_urinary_system	1.48847885
41	MP0002063_abnormal_learning/memory/cond	1.48441595
42	MP0002064_seizures	1.46799487
43	MP0002557_abnormal_social/conspecific_i	1.46727009
44	MP0001968_abnormal_touch/_nociception	1.46668601
45	MP0003136_yellow_coat_color	1.46415544
46	MP0008789_abnormal_olfactory_epithelium	1.45051349
47	MP0004142_abnormal_muscle_tone	1.44553841
48	MP0001486_abnormal_startle_reflex	1.43973892
49	MP0001970_abnormal_pain_threshold	1.43027733
50	MP0003011_delayed_dark_adaptation	1.41001505
51	MP0000955_abnormal_spinal_cord	1.40040171
52	MP0001986_abnormal_taste_sensitivity	1.39493487
53	MP0000026_abnormal_inner_ear	1.38061973
54	MP0002572_abnormal_emotion/affect_behav	1.36916301
55	MP0000049_abnormal_middle_ear	1.35559934
56	MP0002752_abnormal_somatic_nervous	1.28835371
57	MP0002734_abnormal_mechanical_nocicepti	1.28059024
58	MP0004019_abnormal_vitamin_homeostasis	1.23132390
59	MP0008775_abnormal_heart_ventricle	1.22045419
60	MP0002102_abnormal_ear_morphology	1.21583947
61	MP0009046_muscle_twitch	1.20757964
62	MP0003938_abnormal_ear_development	1.20638582
63	MP0002928_abnormal_bile_duct	1.20030331
64	MP0002882_abnormal_neuron_morphology	1.19068928
65	MP0002938_white_spotting	1.17120874
66	MP0008995_early_reproductive_senescence	1.16686256
67	MP0005394_taste/olfaction_phenotype	1.16578468
68	MP0005499_abnormal_olfactory_system	1.16578468
69	MP0005645_abnormal_hypothalamus_physiol	1.15918983
70	MP0002067_abnormal_sensory_capabilities	1.15440718
71	MP0001963_abnormal_hearing_physiology	1.14696818
72	MP0001293_anophthalmia	1.11097902
73	MP0001905_abnormal_dopamine_level	1.07403871
74	MP0005195_abnormal_posterior_eye	1.07263773
75	MP0001529_abnormal_vocalization	1.04324197
76	MP0002138_abnormal_hepatobiliary_system	1.04195304
77	MP0004859_abnormal_synaptic_plasticity	1.03406138
78	MP0002735_abnormal_chemical_nociception	1.03375388
79	MP0006072_abnormal_retinal_apoptosis	1.00164432
80	MP0001919_abnormal_reproductive_system	0.99532484
81	MP0001984_abnormal_olfaction	0.97447776
82	MP0004924_abnormal_behavior	0.95645148
83	MP0005386_behavior/neurological_phenoty	0.95645148
84	MP0004085_abnormal_heartbeat	0.95477287
85	MP0008872_abnormal_physiological_respon	0.95080482
86	MP0003195_calcinosis	0.93439800
87	MP0002229_neurodegeneration	0.93034423
88	MP0000230_abnormal_systemic_arterial	0.89873987
89	MP0000534_abnormal_ureter_morphology	0.89614594
90	MP0002152_abnormal_brain_morphology	0.88489110
91	MP0002736_abnormal_nociception_after	0.85244785
92	MP0003878_abnormal_ear_physiology	0.83564692
93	MP0005377_hearing/vestibular/ear_phenot	0.83564692
94	MP0003119_abnormal_digestive_system	0.81285328
95	MP0001502_abnormal_circadian_rhythm	0.80674909
96	MP0001542_abnormal_bone_strength	0.80649540
97	MP0005379_endocrine/exocrine_gland_phen	0.80029084
98	MP0010386_abnormal_urinary_bladder	0.78610606
99	MP0000427_abnormal_hair_cycle	0.77758432
100	MP0004270_analgesia	0.76523142

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nephronophthisis (HP:0000090)	3.91207624
2	Abnormality of midbrain morphology (HP:0002418)	3.61114344
3	Molar tooth sign on MRI (HP:0002419)	3.61114344
4	Decreased circulating renin level (HP:0003351)	3.57065315
5	Abnormality of the renal collecting system (HP:0004742)	3.51330328
6	True hermaphroditism (HP:0010459)	3.50168369
7	Pancreatic fibrosis (HP:0100732)	3.46233407
8	Stenosis of the external auditory canal (HP:0000402)	3.44482920
9	Osteomalacia (HP:0002749)	3.41145773
10	Abnormality of the renal medulla (HP:0100957)	3.22841113
11	Progressive cerebellar ataxia (HP:0002073)	3.09564861
12	Pancreatic cysts (HP:0001737)	3.08622747
13	Medial flaring of the eyebrow (HP:0010747)	3.06580646
14	Clumsiness (HP:0002312)	2.91092633
15	Abnormality of cochlea (HP:0000375)	2.90516209
16	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.89497062
17	Short 4th metacarpal (HP:0010044)	2.89497062
18	Metabolic alkalosis (HP:0200114)	2.80921895
19	Abolished electroretinogram (ERG) (HP:0000550)	2.77861790
20	Gait imbalance (HP:0002141)	2.72148266
21	Myokymia (HP:0002411)	2.66855645
22	Chronic hepatic failure (HP:0100626)	2.63310112
23	Congenital stationary night blindness (HP:0007642)	2.61560205
24	Tubular atrophy (HP:0000092)	2.57699949
25	Abnormality of the 4th metacarpal (HP:0010012)	2.54279267
26	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.53601136
27	Genetic anticipation (HP:0003743)	2.52650297
28	Congenital primary aphakia (HP:0007707)	2.49306844
29	Short femoral neck (HP:0100864)	2.47664218
30	Agitation (HP:0000713)	2.47478798
31	Megalencephaly (HP:0001355)	2.45333475
32	Abnormal pancreas size (HP:0012094)	2.42314160
33	Morphological abnormality of the inner ear (HP:0011390)	2.40840330
34	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.39957262
35	Nephrogenic diabetes insipidus (HP:0009806)	2.39705415
36	Septo-optic dysplasia (HP:0100842)	2.37077819
37	Adrenal hypoplasia (HP:0000835)	2.34593649
38	Sclerocornea (HP:0000647)	2.29773882
39	Abnormality of the right ventricle (HP:0001707)	2.27800157
40	Broad-based gait (HP:0002136)	2.27065027
41	Morphological abnormality of the middle ear (HP:0008609)	2.24699659
42	Down-sloping shoulders (HP:0200021)	2.22987745
43	Hyperglycinemia (HP:0002154)	2.22001242
44	Asplenia (HP:0001746)	2.21766473
45	Male pseudohermaphroditism (HP:0000037)	2.21678933
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.21217076
47	Hyperventilation (HP:0002883)	2.21138293
48	Reticulocytopenia (HP:0001896)	2.20052184
49	Cystic liver disease (HP:0006706)	2.19030847
50	Periauricular skin pits (HP:0100277)	2.17236664
51	Preauricular pit (HP:0004467)	2.17236664
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.16324072
53	Patent foramen ovale (HP:0001655)	2.15630075
54	Abnormality of cells of the erythroid lineage (HP:0012130)	2.14023207
55	Short tibia (HP:0005736)	2.12638154
56	Rib fusion (HP:0000902)	2.11712644
57	Limb dystonia (HP:0002451)	2.09349477
58	Vaginal atresia (HP:0000148)	2.09304177
59	Abnormality of renin-angiotensin system (HP:0000847)	2.09071163
60	Oligodontia (HP:0000677)	2.08966804
61	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.05207715
62	Hypoplasia of the ulna (HP:0003022)	2.05110029
63	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.04995709
64	Genital tract atresia (HP:0001827)	2.04883856
65	Anomalous pulmonary venous return (HP:0010772)	2.03753327
66	Abnormal drinking behavior (HP:0030082)	2.03070866
67	Polydipsia (HP:0001959)	2.03070866
68	Abnormality of the renal cortex (HP:0011035)	2.02787386
69	Fibular hypoplasia (HP:0003038)	2.02440138
70	Renal dysplasia (HP:0000110)	2.00850227
71	Abnormality of renal resorption (HP:0011038)	2.00590686
72	Anencephaly (HP:0002323)	2.00010686
73	Drooling (HP:0002307)	1.98965776
74	Abnormal respiratory epithelium morphology (HP:0012253)	1.98919125
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.98919125
76	Focal seizures (HP:0007359)	1.98030205
77	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.97133487
78	Epileptic encephalopathy (HP:0200134)	1.97008009
79	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.96564547
80	Specific learning disability (HP:0001328)	1.95505880
81	Abnormal rod and cone electroretinograms (HP:0008323)	1.95304144
82	Abnormality of the corticospinal tract (HP:0002492)	1.94480579
83	Mesomelia (HP:0003027)	1.94352022
84	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.93104637
85	Abnormality of the middle phalanges of the toes (HP:0010183)	1.91520433
86	Cerebral palsy (HP:0100021)	1.90102152
87	Abnormality of renal excretion (HP:0011036)	1.90033405
88	Type II lissencephaly (HP:0007260)	1.89634434
89	Poor coordination (HP:0002370)	1.88764529
90	Small hand (HP:0200055)	1.88371443
91	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.88285774
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.86327666
93	Absent/shortened dynein arms (HP:0200106)	1.86327666
94	Congenital, generalized hypertrichosis (HP:0004540)	1.86224955
95	Congenital hepatic fibrosis (HP:0002612)	1.83832287
96	Tachypnea (HP:0002789)	1.83728071
97	Hepatoblastoma (HP:0002884)	1.83509378
98	Polyphagia (HP:0002591)	1.82241360
99	Diastasis recti (HP:0001540)	1.81875636
100	Patellar aplasia (HP:0006443)	1.80307778

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.90065860
2	WNK4	3.40368487
3	CASK	3.00415056
4	STK16	2.91176354
5	SIK2	2.37335363
6	ADRBK2	2.34020345
7	MAP3K9	2.16968755
8	STK39	2.16357594
9	TLK1	2.14311188
10	NTRK3	2.13883868
11	BMPR1B	1.90799969
12	MARK1	1.85929329
13	DYRK2	1.85466459
14	GRK1	1.85187538
15	NTRK2	1.85159375
16	RPS6KA2	1.84502041
17	MAP3K4	1.83541543
18	TAOK3	1.83223558
19	ZAK	1.79824518
20	ACVR1B	1.73948480
21	PINK1	1.72380547
22	SGK2	1.64695884
23	SGK223	1.64675129
24	SGK494	1.64675129
25	TYRO3	1.56490611
26	RPS6KA6	1.40869188
27	MAP2K7	1.40079902
28	PRKCG	1.36023348
29	WNK3	1.34207936
30	EPHB2	1.33846350
31	PIK3CA	1.30349073
32	PNCK	1.28296620
33	MAPK13	1.27240617
34	STK11	1.16723905
35	OXSR1	1.14289303
36	PAK3	1.13258798
37	RPS6KL1	1.13180348
38	RPS6KC1	1.13180348
39	INSRR	1.13177677
40	TNIK	1.12536811
41	ADRBK1	1.08676177
42	TIE1	1.05372549
43	MAPK15	1.02537305
44	MAP3K11	1.01738213
45	MARK2	1.00144168
46	TXK	0.99649089
47	CAMK1D	0.98745117
48	GRK7	0.97743072
49	CAMK1G	0.96781651
50	CAMK1	0.91178224
51	SGK1	0.89859830
52	PRKACA	0.86499230
53	SGK3	0.85846466
54	MAP2K4	0.85302100
55	ERBB2	0.80768945
56	DAPK2	0.80727871
57	PRKCZ	0.75822662
58	CAMKK2	0.75621458
59	PKN1	0.74970106
60	PRKCH	0.73451912
61	DYRK1A	0.73276427
62	BRAF	0.72974318
63	MINK1	0.70649635
64	NUAK1	0.70250677
65	EPHA4	0.68866017
66	CAMKK1	0.68480371
67	DYRK3	0.64563254
68	CDK5	0.64306767
69	MUSK	0.62277373
70	PRKCQ	0.59223630
71	WNK1	0.58693225
72	CDK19	0.57722274
73	PLK2	0.57606080
74	PRKCE	0.55723382
75	RPS6KA5	0.55707009
76	CAMK2A	0.55352630
77	MAP2K2	0.53483395
78	FGFR2	0.51337264
79	PRKACG	0.51006960
80	BCKDK	0.48156453
81	ABL2	0.47310655
82	VRK1	0.46957747
83	DMPK	0.46596550
84	PRKCA	0.45626853
85	CAMK4	0.45332443
86	RPS6KA3	0.43975079
87	AURKA	0.43218188
88	RPS6KA1	0.41481977
89	CSNK1A1	0.40301631
90	CSNK1G2	0.38360400
91	MAP4K2	0.37494120
92	PLK4	0.34796425
93	AKT1	0.34380288
94	TGFBR1	0.34183207
95	CHUK	0.33996210
96	MKNK2	0.32156795
97	MAPK4	0.32074654
98	AKT3	0.31965700
99	PTK2B	0.29754225
100	MARK3	0.29702988

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.00165671
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.89643502
3	Ribosome_Homo sapiens_hsa03010	2.82514287
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.59129849
5	Phototransduction_Homo sapiens_hsa04744	2.58534395
6	Parkinsons disease_Homo sapiens_hsa05012	2.27633735
7	Morphine addiction_Homo sapiens_hsa05032	2.08353094
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.07982511
9	Glutamatergic synapse_Homo sapiens_hsa04724	2.07611644
10	Serotonergic synapse_Homo sapiens_hsa04726	1.96610628
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.88541215
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.88451589
13	Alzheimers disease_Homo sapiens_hsa05010	1.85843850
14	Circadian entrainment_Homo sapiens_hsa04713	1.85389121
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.79951099
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.77930973
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.77580977
18	GABAergic synapse_Homo sapiens_hsa04727	1.71451106
19	Cholinergic synapse_Homo sapiens_hsa04725	1.70163880
20	Huntingtons disease_Homo sapiens_hsa05016	1.65051462
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.61656562
22	Cocaine addiction_Homo sapiens_hsa05030	1.61636731
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.54236510
24	Dopaminergic synapse_Homo sapiens_hsa04728	1.54061696
25	Insulin secretion_Homo sapiens_hsa04911	1.49742718
26	Olfactory transduction_Homo sapiens_hsa04740	1.47319348
27	Retinol metabolism_Homo sapiens_hsa00830	1.46288934
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.44647591
29	Protein export_Homo sapiens_hsa03060	1.38731924
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.34107218
31	Axon guidance_Homo sapiens_hsa04360	1.32782265
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.27951821
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.26258788
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26151219
35	Taste transduction_Homo sapiens_hsa04742	1.17112230
36	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.14435326
37	Sulfur relay system_Homo sapiens_hsa04122	1.08882175
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.08044291
39	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.07316249
40	Amphetamine addiction_Homo sapiens_hsa05031	1.06979845
41	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.06014582
42	Basal cell carcinoma_Homo sapiens_hsa05217	1.05600849
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04787933
44	Peroxisome_Homo sapiens_hsa04146	1.03538370
45	Type II diabetes mellitus_Homo sapiens_hsa04930	1.02956822
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02556766
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02510872
48	Renin secretion_Homo sapiens_hsa04924	1.01767503
49	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00987866
50	Ether lipid metabolism_Homo sapiens_hsa00565	1.00642350
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97038906
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.91537098
53	Calcium signaling pathway_Homo sapiens_hsa04020	0.91004093
54	Long-term depression_Homo sapiens_hsa04730	0.87872962
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87119436
56	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.86671234
57	MAPK signaling pathway_Homo sapiens_hsa04010	0.86339563
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.84333842
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.83394584
60	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.82516074
61	Butanoate metabolism_Homo sapiens_hsa00650	0.82012751
62	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.81261092
63	cAMP signaling pathway_Homo sapiens_hsa04024	0.80776149
64	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.79070451
65	RNA polymerase_Homo sapiens_hsa03020	0.78634334
66	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.77474908
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.77069490
68	Gastric acid secretion_Homo sapiens_hsa04971	0.75529407
69	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.74668041
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73513413
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71864049
72	RNA degradation_Homo sapiens_hsa03018	0.70667976
73	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.70153543
74	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68191994
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.63822114
76	Alcoholism_Homo sapiens_hsa05034	0.63712798
77	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63284471
78	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.63160623
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60746666
80	Ras signaling pathway_Homo sapiens_hsa04014	0.59504791
81	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.58607426
82	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.57522286
83	Melanoma_Homo sapiens_hsa05218	0.56546650
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.56425466
85	Basal transcription factors_Homo sapiens_hsa03022	0.53060253
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51854036
87	Phenylalanine metabolism_Homo sapiens_hsa00360	0.49325674
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.47556332
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.47193387
90	Salivary secretion_Homo sapiens_hsa04970	0.45149394
91	Bile secretion_Homo sapiens_hsa04976	0.43265798
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.41995737
93	Caffeine metabolism_Homo sapiens_hsa00232	0.41671364
94	Notch signaling pathway_Homo sapiens_hsa04330	0.38085111
95	ABC transporters_Homo sapiens_hsa02010	0.37107536
96	Rap1 signaling pathway_Homo sapiens_hsa04015	0.36044400
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.35626994
98	Metabolic pathways_Homo sapiens_hsa01100	0.34603428
99	Long-term potentiation_Homo sapiens_hsa04720	0.33639814
100	Histidine metabolism_Homo sapiens_hsa00340	0.33405470

NPM1P40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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