

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 6.83218686 |
| 2 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.47054574 |
| 3 | regulation of immunoglobulin secretion (GO:0051023) | 6.37435491 |
| 4 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 6.00600390 |
| 5 | proteasome assembly (GO:0043248) | 5.86574142 |
| 6 | DNA deamination (GO:0045006) | 5.35748601 |
| 7 | rRNA methylation (GO:0031167) | 5.19281959 |
| 8 | rRNA modification (GO:0000154) | 5.15833984 |
| 9 | regulation of regulatory T cell differentiation (GO:0045589) | 4.93979581 |
| 10 | regulation of chronic inflammatory response (GO:0002676) | 4.76171829 |
| 11 | positive regulation of isotype switching (GO:0045830) | 4.71458562 |
| 12 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.53454160 |
| 13 | positive regulation of DNA recombination (GO:0045911) | 4.50457716 |
| 14 | maturation of 5.8S rRNA (GO:0000460) | 4.47493763 |
| 15 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.94741156 |
| 16 | termination of RNA polymerase I transcription (GO:0006363) | 3.92875612 |
| 17 | DNA double-strand break processing (GO:0000729) | 3.92005624 |
| 18 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.88666329 |
| 19 | positive regulation of B cell mediated immunity (GO:0002714) | 3.71311396 |
| 20 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.71311396 |
| 21 | positive regulation of interleukin-17 production (GO:0032740) | 3.69409894 |
| 22 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.64256149 |
| 23 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.62288981 |
| 24 | GTP biosynthetic process (GO:0006183) | 3.58375945 |
| 25 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.52818816 |
| 26 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.51608008 |
| 27 | isotype switching (GO:0045190) | 3.51608008 |
| 28 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.51608008 |
| 29 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.49560945 |
| 30 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.47589948 |
| 31 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.47589948 |
| 32 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.47589948 |
| 33 | pseudouridine synthesis (GO:0001522) | 3.47153994 |
| 34 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.46826622 |
| 35 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.46066164 |
| 36 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.43800950 |
| 37 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.43800950 |
| 38 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.39238066 |
| 39 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.34747157 |
| 40 | mitochondrial RNA metabolic process (GO:0000959) | 3.34470113 |
| 41 | ribosome assembly (GO:0042255) | 3.32678158 |
| 42 | negative regulation of B cell apoptotic process (GO:0002903) | 3.32449373 |
| 43 | positive regulation of immunoglobulin production (GO:0002639) | 3.28652241 |
| 44 | IMP biosynthetic process (GO:0006188) | 3.27860932 |
| 45 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.27547665 |
| 46 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.27547665 |
| 47 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.24450372 |
| 48 | rRNA processing (GO:0006364) | 3.23981903 |
| 49 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.23208494 |
| 50 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.22168718 |
| 51 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.22168718 |
| 52 | ribosome biogenesis (GO:0042254) | 3.18067263 |
| 53 | regulation of isotype switching (GO:0045191) | 3.17872243 |
| 54 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.17178780 |
| 55 | regulation of podosome assembly (GO:0071801) | 3.16368847 |
| 56 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.14975083 |
| 57 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.14602810 |
| 58 | negative regulation of ligase activity (GO:0051352) | 3.14602810 |
| 59 | rRNA metabolic process (GO:0016072) | 3.14499163 |
| 60 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.12239940 |
| 61 | nucleotide transmembrane transport (GO:1901679) | 3.09934710 |
| 62 | regulation of immunoglobulin production (GO:0002637) | 3.08978764 |
| 63 | protein neddylation (GO:0045116) | 3.03445860 |
| 64 | respiratory chain complex IV assembly (GO:0008535) | 3.03135641 |
| 65 | UTP biosynthetic process (GO:0006228) | 3.01352464 |
| 66 | response to pheromone (GO:0019236) | 3.00976683 |
| 67 | tRNA aminoacylation (GO:0043039) | 2.98737324 |
| 68 | amino acid activation (GO:0043038) | 2.98737324 |
| 69 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.98571929 |
| 70 | cytidine deamination (GO:0009972) | 2.97790245 |
| 71 | cytidine metabolic process (GO:0046087) | 2.97790245 |
| 72 | cytidine catabolic process (GO:0006216) | 2.97790245 |
| 73 | positive regulation of ligase activity (GO:0051351) | 2.96544986 |
| 74 | UTP metabolic process (GO:0046051) | 2.96539328 |
| 75 | CTP metabolic process (GO:0046036) | 2.95402617 |
| 76 | CTP biosynthetic process (GO:0006241) | 2.95402617 |
| 77 | piRNA metabolic process (GO:0034587) | 2.95288933 |
| 78 | signal peptide processing (GO:0006465) | 2.93035868 |
| 79 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.92795435 |
| 80 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.91838662 |
| 81 | ATP synthesis coupled proton transport (GO:0015986) | 2.91838662 |
| 82 | transcription from RNA polymerase I promoter (GO:0006360) | 2.91335430 |
| 83 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.91070005 |
| 84 | tRNA aminoacylation for protein translation (GO:0006418) | 2.88983824 |
| 85 | transcription from mitochondrial promoter (GO:0006390) | 2.86801358 |
| 86 | DNA damage response, detection of DNA damage (GO:0042769) | 2.85445629 |
| 87 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.81938473 |
| 88 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.81752513 |
| 89 | IMP metabolic process (GO:0046040) | 2.81164904 |
| 90 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.80159030 |
| 91 | termination of RNA polymerase III transcription (GO:0006386) | 2.80159030 |
| 92 | protein complex biogenesis (GO:0070271) | 2.78114328 |
| 93 | positive regulation of defense response to virus by host (GO:0002230) | 2.77965131 |
| 94 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 2.77790145 |
| 95 | positive regulation of cell cycle arrest (GO:0071158) | 2.76399638 |
| 96 | peptidyl-histidine modification (GO:0018202) | 2.75782247 |
| 97 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.74270321 |
| 98 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.74218808 |
| 99 | chaperone-mediated protein transport (GO:0072321) | 2.74042227 |
| 100 | tRNA metabolic process (GO:0006399) | 2.69678674 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.89920554 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.42665057 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.41010446 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.66163078 |
| 5 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.95894711 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.71056821 |
| 7 | VDR_22108803_ChIP-Seq_LS180_Human | 2.66611315 |
| 8 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.60785857 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.56856867 |
| 10 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.55407483 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.54589395 |
| 12 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.54099096 |
| 13 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.48110770 |
| 14 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.24281841 |
| 15 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.19785218 |
| 16 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12465902 |
| 17 | EWS_26573619_Chip-Seq_HEK293_Human | 2.12117547 |
| 18 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 2.09912008 |
| 19 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.05196484 |
| 20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.02186580 |
| 21 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.99295197 |
| 22 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.98265266 |
| 23 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.97804948 |
| 24 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.89653887 |
| 25 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.88227554 |
| 26 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.86967296 |
| 27 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.84367306 |
| 28 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.80540819 |
| 29 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.65291360 |
| 30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.60288965 |
| 31 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.56869391 |
| 32 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.56800336 |
| 33 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.55260064 |
| 34 | P300_19829295_ChIP-Seq_ESCs_Human | 1.54123174 |
| 35 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.53681649 |
| 36 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.51474354 |
| 37 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.50952744 |
| 38 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.48373842 |
| 39 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.44206856 |
| 40 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.41508176 |
| 41 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.41404966 |
| 42 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.40578480 |
| 43 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.39332941 |
| 44 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.38952556 |
| 45 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.36001210 |
| 46 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.33791616 |
| 47 | FUS_26573619_Chip-Seq_HEK293_Human | 1.33385580 |
| 48 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.31457187 |
| 49 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.26244691 |
| 50 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.25847990 |
| 51 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.24535228 |
| 52 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.24193303 |
| 53 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.23730830 |
| 54 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.22721806 |
| 55 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.22299290 |
| 56 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.21800997 |
| 57 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.21152341 |
| 58 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.20977881 |
| 59 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.20977881 |
| 60 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.18265711 |
| 61 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.18138457 |
| 62 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.17654391 |
| 63 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.17295778 |
| 64 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.17295778 |
| 65 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.14348707 |
| 66 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.14227166 |
| 67 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.11748598 |
| 68 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.11672949 |
| 69 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.10027867 |
| 70 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.09118384 |
| 71 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.09046623 |
| 72 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.09031105 |
| 73 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.08845467 |
| 74 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.08497466 |
| 75 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.08272848 |
| 76 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.07719094 |
| 77 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06700907 |
| 78 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.04899956 |
| 79 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.04878514 |
| 80 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.02995420 |
| 81 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.01643764 |
| 82 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.00951952 |
| 83 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.99980909 |
| 84 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.99499249 |
| 85 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.99197029 |
| 86 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.97701384 |
| 87 | GATA3_26560356_Chip-Seq_TH2_Human | 0.96968256 |
| 88 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.96843905 |
| 89 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.96721556 |
| 90 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.96010117 |
| 91 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 0.95448869 |
| 92 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.95118319 |
| 93 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.94409209 |
| 94 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.94278375 |
| 95 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.94036091 |
| 96 | AR_20517297_ChIP-Seq_VCAP_Human | 0.93207849 |
| 97 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.93113854 |
| 98 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.93092977 |
| 99 | CTCF_18555785_Chip-Seq_ESCs_Mouse | 0.92560250 |
| 100 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.92461395 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.26589393 |
| 2 | MP0004147_increased_porphyrin_level | 3.17775765 |
| 3 | MP0003718_maternal_effect | 2.94802415 |
| 4 | MP0002138_abnormal_hepatobiliary_system | 2.91300285 |
| 5 | MP0002102_abnormal_ear_morphology | 2.90953253 |
| 6 | MP0001853_heart_inflammation | 2.72500900 |
| 7 | MP0000685_abnormal_immune_system | 2.67867787 |
| 8 | MP0001873_stomach_inflammation | 2.56803459 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.41495730 |
| 10 | MP0003786_premature_aging | 2.16709982 |
| 11 | MP0008058_abnormal_DNA_repair | 2.12543870 |
| 12 | MP0002148_abnormal_hypersensitivity_rea | 2.12117490 |
| 13 | MP0002736_abnormal_nociception_after | 2.07223873 |
| 14 | MP0000372_irregular_coat_pigmentation | 2.06443468 |
| 15 | MP0008875_abnormal_xenobiotic_pharmacok | 2.01090474 |
| 16 | MP0001790_abnormal_immune_system | 1.95868590 |
| 17 | MP0005387_immune_system_phenotype | 1.95868590 |
| 18 | MP0006072_abnormal_retinal_apoptosis | 1.92831792 |
| 19 | MP0002837_dystrophic_cardiac_calcinosis | 1.90841841 |
| 20 | MP0005671_abnormal_response_to | 1.89768010 |
| 21 | MP0002876_abnormal_thyroid_physiology | 1.89087223 |
| 22 | MP0003186_abnormal_redox_activity | 1.88915149 |
| 23 | MP0001968_abnormal_touch/_nociception | 1.79639124 |
| 24 | MP0004782_abnormal_surfactant_physiolog | 1.79605351 |
| 25 | MP0003195_calcinosis | 1.77555460 |
| 26 | MP0000604_amyloidosis | 1.73242447 |
| 27 | MP0004957_abnormal_blastocyst_morpholog | 1.71296766 |
| 28 | MP0009333_abnormal_splenocyte_physiolog | 1.69412306 |
| 29 | MP0008872_abnormal_physiological_respon | 1.69056662 |
| 30 | MP0005646_abnormal_pituitary_gland | 1.65460189 |
| 31 | MP0005551_abnormal_eye_electrophysiolog | 1.63314668 |
| 32 | MP0003693_abnormal_embryo_hatching | 1.54286771 |
| 33 | MP0006036_abnormal_mitochondrial_physio | 1.53666581 |
| 34 | MP0002254_reproductive_system_inflammat | 1.51284624 |
| 35 | MP0003567_abnormal_fetal_cardiomyocyte | 1.50050350 |
| 36 | MP0009785_altered_susceptibility_to | 1.48827428 |
| 37 | MP0001293_anophthalmia | 1.46385903 |
| 38 | MP0006035_abnormal_mitochondrial_morpho | 1.45047227 |
| 39 | MP0002277_abnormal_respiratory_mucosa | 1.43574113 |
| 40 | MP0005084_abnormal_gallbladder_morpholo | 1.43422251 |
| 41 | MP0002006_tumorigenesis | 1.42281669 |
| 42 | MP0008057_abnormal_DNA_replication | 1.38900802 |
| 43 | MP0003300_gastrointestinal_ulcer | 1.37717008 |
| 44 | MP0002166_altered_tumor_susceptibility | 1.36984027 |
| 45 | MP0005645_abnormal_hypothalamus_physiol | 1.36725609 |
| 46 | MP0003011_delayed_dark_adaptation | 1.35766204 |
| 47 | MP0006292_abnormal_olfactory_placode | 1.31293563 |
| 48 | MP0010094_abnormal_chromosome_stability | 1.30271487 |
| 49 | MP0005408_hypopigmentation | 1.29123037 |
| 50 | MP0005075_abnormal_melanosome_morpholog | 1.27665228 |
| 51 | MP0001501_abnormal_sleep_pattern | 1.27188870 |
| 52 | MP0009697_abnormal_copulation | 1.21953310 |
| 53 | MP0003806_abnormal_nucleotide_metabolis | 1.18826112 |
| 54 | MP0004145_abnormal_muscle_electrophysio | 1.18376180 |
| 55 | MP0005636_abnormal_mineral_homeostasis | 1.16823441 |
| 56 | MP0002234_abnormal_pharynx_morphology | 1.14571525 |
| 57 | MP0002405_respiratory_system_inflammati | 1.14418145 |
| 58 | MP0003646_muscle_fatigue | 1.08925409 |
| 59 | MP0002822_catalepsy | 1.08310587 |
| 60 | MP0005332_abnormal_amino_acid | 1.06846784 |
| 61 | MP0000465_gastrointestinal_hemorrhage | 1.06531832 |
| 62 | MP0005253_abnormal_eye_physiology | 1.05832141 |
| 63 | MP0003137_abnormal_impulse_conducting | 1.03051388 |
| 64 | MP0002693_abnormal_pancreas_physiology | 1.00500113 |
| 65 | MP0002938_white_spotting | 0.99798191 |
| 66 | MP0001881_abnormal_mammary_gland | 0.97754846 |
| 67 | MP0005379_endocrine/exocrine_gland_phen | 0.95700648 |
| 68 | MP0005395_other_phenotype | 0.95643373 |
| 69 | MP0001188_hyperpigmentation | 0.93429410 |
| 70 | MP0001800_abnormal_humoral_immune | 0.92315544 |
| 71 | MP0005377_hearing/vestibular/ear_phenot | 0.90284156 |
| 72 | MP0003878_abnormal_ear_physiology | 0.90284156 |
| 73 | MP0004885_abnormal_endolymph | 0.90048184 |
| 74 | MP0004142_abnormal_muscle_tone | 0.87655230 |
| 75 | MP0005389_reproductive_system_phenotype | 0.87073998 |
| 76 | MP0000631_abnormal_neuroendocrine_gland | 0.86618745 |
| 77 | MP0001529_abnormal_vocalization | 0.84741630 |
| 78 | MP0001919_abnormal_reproductive_system | 0.82548820 |
| 79 | MP0003866_abnormal_defecation | 0.81520745 |
| 80 | MP0004381_abnormal_hair_follicle | 0.79903631 |
| 81 | MP0004043_abnormal_pH_regulation | 0.78652401 |
| 82 | MP0008007_abnormal_cellular_replicative | 0.77109826 |
| 83 | MP0001984_abnormal_olfaction | 0.75395206 |
| 84 | MP0005167_abnormal_blood-brain_barrier | 0.73407121 |
| 85 | MP0002272_abnormal_nervous_system | 0.73214510 |
| 86 | MP0008873_increased_physiological_sensi | 0.72774344 |
| 87 | MP0002751_abnormal_autonomic_nervous | 0.72548223 |
| 88 | MP0001958_emphysema | 0.72165285 |
| 89 | MP0000689_abnormal_spleen_morphology | 0.71897676 |
| 90 | MP0000427_abnormal_hair_cycle | 0.71082127 |
| 91 | MP0002160_abnormal_reproductive_system | 0.70382932 |
| 92 | MP0004019_abnormal_vitamin_homeostasis | 0.70308017 |
| 93 | MP0005410_abnormal_fertilization | 0.69777168 |
| 94 | MP0003936_abnormal_reproductive_system | 0.69404901 |
| 95 | MP0005220_abnormal_exocrine_pancreas | 0.68107541 |
| 96 | MP0003077_abnormal_cell_cycle | 0.67111543 |
| 97 | MP0001905_abnormal_dopamine_level | 0.66367335 |
| 98 | MP0001661_extended_life_span | 0.64295883 |
| 99 | MP0002735_abnormal_chemical_nociception | 0.64215009 |
| 100 | MP0004270_analgesia | 0.64030974 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Stomatitis (HP:0010280) | 5.68918077 |
| 2 | Decreased circulating renin level (HP:0003351) | 4.47479438 |
| 3 | Increased hepatocellular lipid droplets (HP:0006565) | 4.20534191 |
| 4 | Lipid accumulation in hepatocytes (HP:0006561) | 3.91712956 |
| 5 | Increased circulating renin level (HP:0000848) | 3.74229344 |
| 6 | IgG deficiency (HP:0004315) | 3.53963699 |
| 7 | Renal Fanconi syndrome (HP:0001994) | 3.38209482 |
| 8 | Increased CSF lactate (HP:0002490) | 3.30786679 |
| 9 | Colon cancer (HP:0003003) | 3.22204239 |
| 10 | Abnormality of the pons (HP:0007361) | 3.18809953 |
| 11 | Acute necrotizing encephalopathy (HP:0006965) | 3.12930991 |
| 12 | Mitochondrial inheritance (HP:0001427) | 3.12705671 |
| 13 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.01939570 |
| 14 | Abnormality of the labia minora (HP:0012880) | 2.99625468 |
| 15 | Methylmalonic acidemia (HP:0002912) | 2.92994803 |
| 16 | Acute encephalopathy (HP:0006846) | 2.90599154 |
| 17 | Hyperactive renin-angiotensin system (HP:0000841) | 2.89053001 |
| 18 | Exertional dyspnea (HP:0002875) | 2.84033635 |
| 19 | Hyperkalemia (HP:0002153) | 2.83400862 |
| 20 | Hypoplasia of the pons (HP:0012110) | 2.70721850 |
| 21 | Increased IgM level (HP:0003496) | 2.68790213 |
| 22 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.67930236 |
| 23 | Progressive macrocephaly (HP:0004481) | 2.63823490 |
| 24 | 3-Methylglutaconic aciduria (HP:0003535) | 2.61414929 |
| 25 | Congenital, generalized hypertrichosis (HP:0004540) | 2.59311745 |
| 26 | Increased serum lactate (HP:0002151) | 2.55463355 |
| 27 | Pancreatic cysts (HP:0001737) | 2.55282414 |
| 28 | Methylmalonic aciduria (HP:0012120) | 2.52458505 |
| 29 | Sensory axonal neuropathy (HP:0003390) | 2.50645265 |
| 30 | Abnormality of renin-angiotensin system (HP:0000847) | 2.42446694 |
| 31 | Hypoplasia of the fovea (HP:0007750) | 2.41082392 |
| 32 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.41082392 |
| 33 | Congenital stationary night blindness (HP:0007642) | 2.40452272 |
| 34 | Abnormality of T cell physiology (HP:0011840) | 2.40282344 |
| 35 | IgA deficiency (HP:0002720) | 2.36341728 |
| 36 | Hepatocellular necrosis (HP:0001404) | 2.35893355 |
| 37 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.35861996 |
| 38 | Abnormality of methionine metabolism (HP:0010901) | 2.33195198 |
| 39 | Optic disc pallor (HP:0000543) | 2.31089279 |
| 40 | Type 2 muscle fiber atrophy (HP:0003554) | 2.26855476 |
| 41 | Gaze-evoked nystagmus (HP:0000640) | 2.21754820 |
| 42 | Abnormality of midbrain morphology (HP:0002418) | 2.20908418 |
| 43 | Molar tooth sign on MRI (HP:0002419) | 2.20908418 |
| 44 | Meckel diverticulum (HP:0002245) | 2.20893168 |
| 45 | Renal cortical cysts (HP:0000803) | 2.20299307 |
| 46 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.19771082 |
| 47 | Abnormality of the ileum (HP:0001549) | 2.19517099 |
| 48 | Hyperaldosteronism (HP:0000859) | 2.16498876 |
| 49 | Abnormality of vitamin B metabolism (HP:0004340) | 2.12798910 |
| 50 | Abnormal albumin level (HP:0012116) | 2.12502339 |
| 51 | Hypoalbuminemia (HP:0003073) | 2.12502339 |
| 52 | Hepatic necrosis (HP:0002605) | 2.10709256 |
| 53 | Abnormality of renal resorption (HP:0011038) | 2.06956299 |
| 54 | Severe visual impairment (HP:0001141) | 2.06024518 |
| 55 | Increased intramyocellular lipid droplets (HP:0012240) | 2.05977092 |
| 56 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.05481184 |
| 57 | Glucose intolerance (HP:0000833) | 2.05366615 |
| 58 | Panhypogammaglobulinemia (HP:0003139) | 2.03044674 |
| 59 | Horseshoe kidney (HP:0000085) | 2.02767219 |
| 60 | Abnormality of the renal cortex (HP:0011035) | 2.02729026 |
| 61 | Abnormality of T cells (HP:0002843) | 2.01789636 |
| 62 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.01750511 |
| 63 | Cerebral edema (HP:0002181) | 2.00617934 |
| 64 | Toxemia of pregnancy (HP:0100603) | 2.00513363 |
| 65 | Respiratory difficulties (HP:0002880) | 2.00351635 |
| 66 | Central scotoma (HP:0000603) | 2.00154443 |
| 67 | Neoplasm of the adrenal gland (HP:0100631) | 1.99669777 |
| 68 | Abnormality of the preputium (HP:0100587) | 1.99423509 |
| 69 | True hermaphroditism (HP:0010459) | 1.99049591 |
| 70 | Thyroiditis (HP:0100646) | 1.97071304 |
| 71 | Abnormality of urine glucose concentration (HP:0011016) | 1.96187179 |
| 72 | Glycosuria (HP:0003076) | 1.96187179 |
| 73 | Hypoproteinemia (HP:0003075) | 1.92771890 |
| 74 | Hyperglycinemia (HP:0002154) | 1.90717431 |
| 75 | Abnormality of potassium homeostasis (HP:0011042) | 1.90184941 |
| 76 | Pancreatic fibrosis (HP:0100732) | 1.88826883 |
| 77 | Lethargy (HP:0001254) | 1.86721088 |
| 78 | Progressive inability to walk (HP:0002505) | 1.86687395 |
| 79 | Type II lissencephaly (HP:0007260) | 1.83809845 |
| 80 | Muscle fiber atrophy (HP:0100295) | 1.82676284 |
| 81 | Oral leukoplakia (HP:0002745) | 1.82145894 |
| 82 | Nephronophthisis (HP:0000090) | 1.80978320 |
| 83 | Pendular nystagmus (HP:0012043) | 1.80002582 |
| 84 | Duplicated collecting system (HP:0000081) | 1.79791010 |
| 85 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.78927455 |
| 86 | Hypomagnesemia (HP:0002917) | 1.77649873 |
| 87 | Attenuation of retinal blood vessels (HP:0007843) | 1.77326237 |
| 88 | Lactic acidosis (HP:0003128) | 1.76260763 |
| 89 | Large for gestational age (HP:0001520) | 1.75774249 |
| 90 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.75184846 |
| 91 | Abnormality of incisor morphology (HP:0011063) | 1.74888661 |
| 92 | Inability to walk (HP:0002540) | 1.74830326 |
| 93 | Abnormality of the fovea (HP:0000493) | 1.74305740 |
| 94 | Abolished electroretinogram (ERG) (HP:0000550) | 1.74266404 |
| 95 | Clubbing of toes (HP:0100760) | 1.73849544 |
| 96 | Severe combined immunodeficiency (HP:0004430) | 1.72819355 |
| 97 | Abnormality of serum amino acid levels (HP:0003112) | 1.71659534 |
| 98 | Aplastic anemia (HP:0001915) | 1.71397259 |
| 99 | Hyperphosphaturia (HP:0003109) | 1.70076580 |
| 100 | Exercise intolerance (HP:0003546) | 1.69798042 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 4.91079920 |
| 2 | EIF2AK3 | 3.75243899 |
| 3 | NUAK1 | 3.57017812 |
| 4 | MST4 | 3.49731360 |
| 5 | EIF2AK1 | 3.21936901 |
| 6 | VRK2 | 2.84198531 |
| 7 | ZAK | 2.46360916 |
| 8 | CASK | 2.46039904 |
| 9 | TAF1 | 2.45383240 |
| 10 | MKNK1 | 2.32399148 |
| 11 | BUB1 | 2.29241399 |
| 12 | TRIM28 | 2.06777893 |
| 13 | FRK | 2.00775899 |
| 14 | MAP2K6 | 1.99108049 |
| 15 | ADRBK2 | 1.97268430 |
| 16 | WNK3 | 1.95071400 |
| 17 | NME1 | 1.94391420 |
| 18 | MKNK2 | 1.91716373 |
| 19 | TXK | 1.89110207 |
| 20 | PLK3 | 1.87223985 |
| 21 | PBK | 1.84432608 |
| 22 | SRPK1 | 1.84290452 |
| 23 | WNK4 | 1.80255837 |
| 24 | EIF2AK2 | 1.73137796 |
| 25 | TLK1 | 1.55165927 |
| 26 | BMPR1B | 1.52698987 |
| 27 | VRK1 | 1.52205649 |
| 28 | NEK1 | 1.49140313 |
| 29 | NME2 | 1.36216266 |
| 30 | STK39 | 1.33129762 |
| 31 | GRK1 | 1.28722478 |
| 32 | DAPK2 | 1.27120175 |
| 33 | ALK | 1.26823450 |
| 34 | TNIK | 1.25473516 |
| 35 | PLK2 | 1.19048369 |
| 36 | MAP4K2 | 1.14533051 |
| 37 | NLK | 1.13311416 |
| 38 | TNK2 | 1.11613326 |
| 39 | MAPKAPK5 | 1.11070129 |
| 40 | TEC | 1.09976208 |
| 41 | IRAK4 | 1.02251846 |
| 42 | OXSR1 | 0.89528304 |
| 43 | FGFR1 | 0.83846517 |
| 44 | ACVR1B | 0.83656213 |
| 45 | PDK2 | 0.80956581 |
| 46 | TAOK3 | 0.80077892 |
| 47 | PIK3CG | 0.78659338 |
| 48 | PLK4 | 0.78491342 |
| 49 | DAPK1 | 0.76732547 |
| 50 | CSNK1G1 | 0.67494805 |
| 51 | PRKCQ | 0.67378204 |
| 52 | TGFBR1 | 0.65932237 |
| 53 | DYRK2 | 0.65387527 |
| 54 | TIE1 | 0.64536506 |
| 55 | CSNK1G2 | 0.61770540 |
| 56 | PAK4 | 0.61259092 |
| 57 | PLK1 | 0.61126444 |
| 58 | CSNK1G3 | 0.58490808 |
| 59 | RPS6KA5 | 0.57912232 |
| 60 | ATR | 0.56335578 |
| 61 | MAP3K9 | 0.56232799 |
| 62 | IKBKB | 0.56106595 |
| 63 | PHKG2 | 0.55836138 |
| 64 | PHKG1 | 0.55836138 |
| 65 | STK4 | 0.55364594 |
| 66 | ITK | 0.54553500 |
| 67 | PAK3 | 0.54313007 |
| 68 | BCKDK | 0.53804658 |
| 69 | CSNK1A1L | 0.52833070 |
| 70 | SIK3 | 0.51621935 |
| 71 | PRKCE | 0.50854828 |
| 72 | KIT | 0.50462091 |
| 73 | TTK | 0.48168074 |
| 74 | PRKCG | 0.47905660 |
| 75 | MUSK | 0.44340779 |
| 76 | STK38L | 0.41832623 |
| 77 | INSRR | 0.41442926 |
| 78 | ADRBK1 | 0.40542600 |
| 79 | PASK | 0.35719980 |
| 80 | PRKD3 | 0.35467278 |
| 81 | IKBKE | 0.34648633 |
| 82 | STK3 | 0.34218758 |
| 83 | CLK1 | 0.33722981 |
| 84 | WEE1 | 0.33502711 |
| 85 | WNK1 | 0.33008004 |
| 86 | CSNK2A2 | 0.31094859 |
| 87 | MAP3K14 | 0.30942884 |
| 88 | CSNK1E | 0.30407415 |
| 89 | CHEK1 | 0.28809167 |
| 90 | ATM | 0.26836008 |
| 91 | STK16 | 0.26432863 |
| 92 | MAPK13 | 0.25454530 |
| 93 | IRAK1 | 0.24871299 |
| 94 | JAK3 | 0.24653607 |
| 95 | GRK5 | 0.24568353 |
| 96 | CSNK2A1 | 0.24004828 |
| 97 | RPS6KA4 | 0.23449485 |
| 98 | MAP3K12 | 0.22901298 |
| 99 | MARK3 | 0.22637270 |
| 100 | CAMK2A | 0.22077710 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.23307300 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.65764795 |
| 3 | Protein export_Homo sapiens_hsa03060 | 3.50445131 |
| 4 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.74984099 |
| 5 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.68878441 |
| 6 | Basal transcription factors_Homo sapiens_hsa03022 | 2.67334655 |
| 7 | Asthma_Homo sapiens_hsa05310 | 2.54745170 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.34691198 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.23797202 |
| 10 | RNA degradation_Homo sapiens_hsa03018 | 2.09217596 |
| 11 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.04432554 |
| 12 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.00089570 |
| 13 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.97611713 |
| 14 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.92923283 |
| 15 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.85833503 |
| 16 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.83422667 |
| 17 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.79404475 |
| 18 | RNA transport_Homo sapiens_hsa03013 | 1.75613670 |
| 19 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.72549539 |
| 20 | Parkinsons disease_Homo sapiens_hsa05012 | 1.68127859 |
| 21 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.63904870 |
| 22 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.60866464 |
| 23 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.50384017 |
| 24 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.44560383 |
| 25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.43653948 |
| 26 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.43621130 |
| 27 | Homologous recombination_Homo sapiens_hsa03440 | 1.41743028 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.27469933 |
| 29 | Ribosome_Homo sapiens_hsa03010 | 1.26833130 |
| 30 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.26532023 |
| 31 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.25648165 |
| 32 | Phototransduction_Homo sapiens_hsa04744 | 1.18676690 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.09453799 |
| 34 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.07476708 |
| 35 | Huntingtons disease_Homo sapiens_hsa05016 | 1.07016759 |
| 36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.07014919 |
| 37 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.06758530 |
| 38 | Spliceosome_Homo sapiens_hsa03040 | 1.03039743 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 1.01464259 |
| 40 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.01193506 |
| 41 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.99993697 |
| 42 | Mismatch repair_Homo sapiens_hsa03430 | 0.98881838 |
| 43 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.98216844 |
| 44 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.97589161 |
| 45 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.94977337 |
| 46 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.92253177 |
| 47 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.91374333 |
| 48 | Peroxisome_Homo sapiens_hsa04146 | 0.90419661 |
| 49 | Alzheimers disease_Homo sapiens_hsa05010 | 0.89249061 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.88231314 |
| 51 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.85901171 |
| 52 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.84222471 |
| 53 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.84132583 |
| 54 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.83754353 |
| 55 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.80043008 |
| 56 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.79330638 |
| 57 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.78026894 |
| 58 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.78025811 |
| 59 | Mineral absorption_Homo sapiens_hsa04978 | 0.73285186 |
| 60 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.71851731 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.70544674 |
| 62 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.69821035 |
| 63 | Retinol metabolism_Homo sapiens_hsa00830 | 0.68330666 |
| 64 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.68149111 |
| 65 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.66211574 |
| 66 | DNA replication_Homo sapiens_hsa03030 | 0.65614041 |
| 67 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.65086126 |
| 68 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.64582357 |
| 69 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.62544871 |
| 70 | Measles_Homo sapiens_hsa05162 | 0.62308788 |
| 71 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.62016410 |
| 72 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.59420303 |
| 73 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.58939138 |
| 74 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.55775994 |
| 75 | Base excision repair_Homo sapiens_hsa03410 | 0.55627118 |
| 76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.54973077 |
| 77 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.54898465 |
| 78 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.52061338 |
| 79 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.51315071 |
| 80 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.47669224 |
| 81 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.45524260 |
| 82 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.45140480 |
| 83 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.43796075 |
| 84 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.42984599 |
| 85 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.42890027 |
| 86 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.42790847 |
| 87 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.41902220 |
| 88 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.41522294 |
| 89 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.40788718 |
| 90 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.38757795 |
| 91 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.38220024 |
| 92 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.37670609 |
| 93 | Carbon metabolism_Homo sapiens_hsa01200 | 0.36767089 |
| 94 | Circadian rhythm_Homo sapiens_hsa04710 | 0.36289118 |
| 95 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.36263509 |
| 96 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.34400588 |
| 97 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.33380838 |
| 98 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.32716910 |
| 99 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.32425205 |
| 100 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.32066430 |

