NPM1P41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)6.83218686
2regulation of isotype switching to IgG isotypes (GO:0048302)6.47054574
3regulation of immunoglobulin secretion (GO:0051023)6.37435491
4regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.00600390
5proteasome assembly (GO:0043248)5.86574142
6DNA deamination (GO:0045006)5.35748601
7rRNA methylation (GO:0031167)5.19281959
8rRNA modification (GO:0000154)5.15833984
9regulation of regulatory T cell differentiation (GO:0045589)4.93979581
10regulation of chronic inflammatory response (GO:0002676)4.76171829
11positive regulation of isotype switching (GO:0045830)4.71458562
12water-soluble vitamin biosynthetic process (GO:0042364)4.53454160
13positive regulation of DNA recombination (GO:0045911)4.50457716
14maturation of 5.8S rRNA (GO:0000460)4.47493763
15transcription elongation from RNA polymerase I promoter (GO:0006362)3.94741156
16termination of RNA polymerase I transcription (GO:0006363)3.92875612
17DNA double-strand break processing (GO:0000729)3.92005624
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.88666329
19positive regulation of B cell mediated immunity (GO:0002714)3.71311396
20positive regulation of immunoglobulin mediated immune response (GO:0002891)3.71311396
21positive regulation of interleukin-17 production (GO:0032740)3.69409894
22regulation of cellular amino acid metabolic process (GO:0006521)3.64256149
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.62288981
24GTP biosynthetic process (GO:0006183)3.58375945
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.52818816
26somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.51608008
27isotype switching (GO:0045190)3.51608008
28somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.51608008
29folic acid-containing compound biosynthetic process (GO:0009396)3.49560945
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47589948
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47589948
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47589948
33pseudouridine synthesis (GO:0001522)3.47153994
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.46826622
35DNA catabolic process, exonucleolytic (GO:0000738)3.46066164
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.43800950
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.43800950
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39238066
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34747157
40mitochondrial RNA metabolic process (GO:0000959)3.34470113
41ribosome assembly (GO:0042255)3.32678158
42negative regulation of B cell apoptotic process (GO:0002903)3.32449373
43positive regulation of immunoglobulin production (GO:0002639)3.28652241
44IMP biosynthetic process (GO:0006188)3.27860932
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27547665
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.27547665
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24450372
48rRNA processing (GO:0006364)3.23981903
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.23208494
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22168718
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22168718
52ribosome biogenesis (GO:0042254)3.18067263
53regulation of isotype switching (GO:0045191)3.17872243
54transcription initiation from RNA polymerase I promoter (GO:0006361)3.17178780
55regulation of podosome assembly (GO:0071801)3.16368847
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.14975083
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14602810
58negative regulation of ligase activity (GO:0051352)3.14602810
59rRNA metabolic process (GO:0016072)3.14499163
60pteridine-containing compound biosynthetic process (GO:0042559)3.12239940
61nucleotide transmembrane transport (GO:1901679)3.09934710
62regulation of immunoglobulin production (GO:0002637)3.08978764
63protein neddylation (GO:0045116)3.03445860
64respiratory chain complex IV assembly (GO:0008535)3.03135641
65UTP biosynthetic process (GO:0006228)3.01352464
66response to pheromone (GO:0019236)3.00976683
67tRNA aminoacylation (GO:0043039)2.98737324
68amino acid activation (GO:0043038)2.98737324
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98571929
70cytidine deamination (GO:0009972)2.97790245
71cytidine metabolic process (GO:0046087)2.97790245
72cytidine catabolic process (GO:0006216)2.97790245
73positive regulation of ligase activity (GO:0051351)2.96544986
74UTP metabolic process (GO:0046051)2.96539328
75CTP metabolic process (GO:0046036)2.95402617
76CTP biosynthetic process (GO:0006241)2.95402617
77piRNA metabolic process (GO:0034587)2.95288933
78signal peptide processing (GO:0006465)2.93035868
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92795435
80energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91838662
81ATP synthesis coupled proton transport (GO:0015986)2.91838662
82transcription from RNA polymerase I promoter (GO:0006360)2.91335430
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91070005
84tRNA aminoacylation for protein translation (GO:0006418)2.88983824
85transcription from mitochondrial promoter (GO:0006390)2.86801358
86DNA damage response, detection of DNA damage (GO:0042769)2.85445629
87mitochondrial respiratory chain complex assembly (GO:0033108)2.81938473
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81752513
89IMP metabolic process (GO:0046040)2.81164904
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.80159030
91termination of RNA polymerase III transcription (GO:0006386)2.80159030
92protein complex biogenesis (GO:0070271)2.78114328
93positive regulation of defense response to virus by host (GO:0002230)2.77965131
94regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.77790145
95positive regulation of cell cycle arrest (GO:0071158)2.76399638
96peptidyl-histidine modification (GO:0018202)2.75782247
97DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.74270321
98positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.74218808
99chaperone-mediated protein transport (GO:0072321)2.74042227
100tRNA metabolic process (GO:0006399)2.69678674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.89920554
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.42665057
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.41010446
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.66163078
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.95894711
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71056821
7VDR_22108803_ChIP-Seq_LS180_Human2.66611315
8VDR_23849224_ChIP-Seq_CD4+_Human2.60785857
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56856867
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55407483
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.54589395
12ELK1_19687146_ChIP-ChIP_HELA_Human2.54099096
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.48110770
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.24281841
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19785218
16FOXP3_21729870_ChIP-Seq_TREG_Human2.12465902
17EWS_26573619_Chip-Seq_HEK293_Human2.12117547
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.09912008
19ZNF274_21170338_ChIP-Seq_K562_Hela2.05196484
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02186580
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99295197
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.98265266
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97804948
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.89653887
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88227554
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86967296
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84367306
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80540819
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65291360
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60288965
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.56869391
32MYC_18940864_ChIP-ChIP_HL60_Human1.56800336
33TP53_22573176_ChIP-Seq_HFKS_Human1.55260064
34P300_19829295_ChIP-Seq_ESCs_Human1.54123174
35DCP1A_22483619_ChIP-Seq_HELA_Human1.53681649
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51474354
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50952744
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48373842
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44206856
40TAF15_26573619_Chip-Seq_HEK293_Human1.41508176
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41404966
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40578480
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.39332941
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38952556
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36001210
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33791616
47FUS_26573619_Chip-Seq_HEK293_Human1.33385580
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31457187
49IGF1R_20145208_ChIP-Seq_DFB_Human1.26244691
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25847990
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.24535228
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24193303
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23730830
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22721806
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22299290
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.21800997
57ER_23166858_ChIP-Seq_MCF-7_Human1.21152341
58NANOG_19829295_ChIP-Seq_ESCs_Human1.20977881
59SOX2_19829295_ChIP-Seq_ESCs_Human1.20977881
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18265711
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18138457
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17654391
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17295778
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.17295778
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14348707
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.14227166
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11748598
68LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11672949
69BCAT_22108803_ChIP-Seq_LS180_Human1.10027867
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.09118384
71TTF2_22483619_ChIP-Seq_HELA_Human1.09046623
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09031105
73GABP_19822575_ChIP-Seq_HepG2_Human1.08845467
74P300_18555785_Chip-Seq_ESCs_Mouse1.08497466
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08272848
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07719094
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06700907
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04899956
79P53_22387025_ChIP-Seq_ESCs_Mouse1.04878514
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02995420
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01643764
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00951952
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99980909
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99499249
85YY1_21170310_ChIP-Seq_MESCs_Mouse0.99197029
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97701384
87GATA3_26560356_Chip-Seq_TH2_Human0.96968256
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96843905
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96721556
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96010117
91NMYC_18555785_Chip-Seq_ESCs_Mouse0.95448869
92HOXB7_26014856_ChIP-Seq_BT474_Human0.95118319
93THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94409209
94CMYC_18555785_Chip-Seq_ESCs_Mouse0.94278375
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94036091
96AR_20517297_ChIP-Seq_VCAP_Human0.93207849
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93113854
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93092977
99CTCF_18555785_Chip-Seq_ESCs_Mouse0.92560250
100RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92461395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.26589393
2MP0004147_increased_porphyrin_level3.17775765
3MP0003718_maternal_effect2.94802415
4MP0002138_abnormal_hepatobiliary_system2.91300285
5MP0002102_abnormal_ear_morphology2.90953253
6MP0001853_heart_inflammation2.72500900
7MP0000685_abnormal_immune_system2.67867787
8MP0001873_stomach_inflammation2.56803459
9MP0008877_abnormal_DNA_methylation2.41495730
10MP0003786_premature_aging2.16709982
11MP0008058_abnormal_DNA_repair2.12543870
12MP0002148_abnormal_hypersensitivity_rea2.12117490
13MP0002736_abnormal_nociception_after2.07223873
14MP0000372_irregular_coat_pigmentation2.06443468
15MP0008875_abnormal_xenobiotic_pharmacok2.01090474
16MP0001790_abnormal_immune_system1.95868590
17MP0005387_immune_system_phenotype1.95868590
18MP0006072_abnormal_retinal_apoptosis1.92831792
19MP0002837_dystrophic_cardiac_calcinosis1.90841841
20MP0005671_abnormal_response_to1.89768010
21MP0002876_abnormal_thyroid_physiology1.89087223
22MP0003186_abnormal_redox_activity1.88915149
23MP0001968_abnormal_touch/_nociception1.79639124
24MP0004782_abnormal_surfactant_physiolog1.79605351
25MP0003195_calcinosis1.77555460
26MP0000604_amyloidosis1.73242447
27MP0004957_abnormal_blastocyst_morpholog1.71296766
28MP0009333_abnormal_splenocyte_physiolog1.69412306
29MP0008872_abnormal_physiological_respon1.69056662
30MP0005646_abnormal_pituitary_gland1.65460189
31MP0005551_abnormal_eye_electrophysiolog1.63314668
32MP0003693_abnormal_embryo_hatching1.54286771
33MP0006036_abnormal_mitochondrial_physio1.53666581
34MP0002254_reproductive_system_inflammat1.51284624
35MP0003567_abnormal_fetal_cardiomyocyte1.50050350
36MP0009785_altered_susceptibility_to1.48827428
37MP0001293_anophthalmia1.46385903
38MP0006035_abnormal_mitochondrial_morpho1.45047227
39MP0002277_abnormal_respiratory_mucosa1.43574113
40MP0005084_abnormal_gallbladder_morpholo1.43422251
41MP0002006_tumorigenesis1.42281669
42MP0008057_abnormal_DNA_replication1.38900802
43MP0003300_gastrointestinal_ulcer1.37717008
44MP0002166_altered_tumor_susceptibility1.36984027
45MP0005645_abnormal_hypothalamus_physiol1.36725609
46MP0003011_delayed_dark_adaptation1.35766204
47MP0006292_abnormal_olfactory_placode1.31293563
48MP0010094_abnormal_chromosome_stability1.30271487
49MP0005408_hypopigmentation1.29123037
50MP0005075_abnormal_melanosome_morpholog1.27665228
51MP0001501_abnormal_sleep_pattern1.27188870
52MP0009697_abnormal_copulation1.21953310
53MP0003806_abnormal_nucleotide_metabolis1.18826112
54MP0004145_abnormal_muscle_electrophysio1.18376180
55MP0005636_abnormal_mineral_homeostasis1.16823441
56MP0002234_abnormal_pharynx_morphology1.14571525
57MP0002405_respiratory_system_inflammati1.14418145
58MP0003646_muscle_fatigue1.08925409
59MP0002822_catalepsy1.08310587
60MP0005332_abnormal_amino_acid1.06846784
61MP0000465_gastrointestinal_hemorrhage1.06531832
62MP0005253_abnormal_eye_physiology1.05832141
63MP0003137_abnormal_impulse_conducting1.03051388
64MP0002693_abnormal_pancreas_physiology1.00500113
65MP0002938_white_spotting0.99798191
66MP0001881_abnormal_mammary_gland0.97754846
67MP0005379_endocrine/exocrine_gland_phen0.95700648
68MP0005395_other_phenotype0.95643373
69MP0001188_hyperpigmentation0.93429410
70MP0001800_abnormal_humoral_immune0.92315544
71MP0005377_hearing/vestibular/ear_phenot0.90284156
72MP0003878_abnormal_ear_physiology0.90284156
73MP0004885_abnormal_endolymph0.90048184
74MP0004142_abnormal_muscle_tone0.87655230
75MP0005389_reproductive_system_phenotype0.87073998
76MP0000631_abnormal_neuroendocrine_gland0.86618745
77MP0001529_abnormal_vocalization0.84741630
78MP0001919_abnormal_reproductive_system0.82548820
79MP0003866_abnormal_defecation0.81520745
80MP0004381_abnormal_hair_follicle0.79903631
81MP0004043_abnormal_pH_regulation0.78652401
82MP0008007_abnormal_cellular_replicative0.77109826
83MP0001984_abnormal_olfaction0.75395206
84MP0005167_abnormal_blood-brain_barrier0.73407121
85MP0002272_abnormal_nervous_system0.73214510
86MP0008873_increased_physiological_sensi0.72774344
87MP0002751_abnormal_autonomic_nervous0.72548223
88MP0001958_emphysema0.72165285
89MP0000689_abnormal_spleen_morphology0.71897676
90MP0000427_abnormal_hair_cycle0.71082127
91MP0002160_abnormal_reproductive_system0.70382932
92MP0004019_abnormal_vitamin_homeostasis0.70308017
93MP0005410_abnormal_fertilization0.69777168
94MP0003936_abnormal_reproductive_system0.69404901
95MP0005220_abnormal_exocrine_pancreas0.68107541
96MP0003077_abnormal_cell_cycle0.67111543
97MP0001905_abnormal_dopamine_level0.66367335
98MP0001661_extended_life_span0.64295883
99MP0002735_abnormal_chemical_nociception0.64215009
100MP0004270_analgesia0.64030974

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.68918077
2Decreased circulating renin level (HP:0003351)4.47479438
3Increased hepatocellular lipid droplets (HP:0006565)4.20534191
4Lipid accumulation in hepatocytes (HP:0006561)3.91712956
5Increased circulating renin level (HP:0000848)3.74229344
6IgG deficiency (HP:0004315)3.53963699
7Renal Fanconi syndrome (HP:0001994)3.38209482
8Increased CSF lactate (HP:0002490)3.30786679
9Colon cancer (HP:0003003)3.22204239
10Abnormality of the pons (HP:0007361)3.18809953
11Acute necrotizing encephalopathy (HP:0006965)3.12930991
12Mitochondrial inheritance (HP:0001427)3.12705671
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.01939570
14Abnormality of the labia minora (HP:0012880)2.99625468
15Methylmalonic acidemia (HP:0002912)2.92994803
16Acute encephalopathy (HP:0006846)2.90599154
17Hyperactive renin-angiotensin system (HP:0000841)2.89053001
18Exertional dyspnea (HP:0002875)2.84033635
19Hyperkalemia (HP:0002153)2.83400862
20Hypoplasia of the pons (HP:0012110)2.70721850
21Increased IgM level (HP:0003496)2.68790213
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.67930236
23Progressive macrocephaly (HP:0004481)2.63823490
243-Methylglutaconic aciduria (HP:0003535)2.61414929
25Congenital, generalized hypertrichosis (HP:0004540)2.59311745
26Increased serum lactate (HP:0002151)2.55463355
27Pancreatic cysts (HP:0001737)2.55282414
28Methylmalonic aciduria (HP:0012120)2.52458505
29Sensory axonal neuropathy (HP:0003390)2.50645265
30Abnormality of renin-angiotensin system (HP:0000847)2.42446694
31Hypoplasia of the fovea (HP:0007750)2.41082392
32Aplasia/Hypoplasia of the fovea (HP:0008060)2.41082392
33Congenital stationary night blindness (HP:0007642)2.40452272
34Abnormality of T cell physiology (HP:0011840)2.40282344
35IgA deficiency (HP:0002720)2.36341728
36Hepatocellular necrosis (HP:0001404)2.35893355
37Abnormal mitochondria in muscle tissue (HP:0008316)2.35861996
38Abnormality of methionine metabolism (HP:0010901)2.33195198
39Optic disc pallor (HP:0000543)2.31089279
40Type 2 muscle fiber atrophy (HP:0003554)2.26855476
41Gaze-evoked nystagmus (HP:0000640)2.21754820
42Abnormality of midbrain morphology (HP:0002418)2.20908418
43Molar tooth sign on MRI (HP:0002419)2.20908418
44Meckel diverticulum (HP:0002245)2.20893168
45Renal cortical cysts (HP:0000803)2.20299307
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19771082
47Abnormality of the ileum (HP:0001549)2.19517099
48Hyperaldosteronism (HP:0000859)2.16498876
49Abnormality of vitamin B metabolism (HP:0004340)2.12798910
50Abnormal albumin level (HP:0012116)2.12502339
51Hypoalbuminemia (HP:0003073)2.12502339
52Hepatic necrosis (HP:0002605)2.10709256
53Abnormality of renal resorption (HP:0011038)2.06956299
54Severe visual impairment (HP:0001141)2.06024518
55Increased intramyocellular lipid droplets (HP:0012240)2.05977092
56Abnormality of the vitamin B12 metabolism (HP:0004341)2.05481184
57Glucose intolerance (HP:0000833)2.05366615
58Panhypogammaglobulinemia (HP:0003139)2.03044674
59Horseshoe kidney (HP:0000085)2.02767219
60Abnormality of the renal cortex (HP:0011035)2.02729026
61Abnormality of T cells (HP:0002843)2.01789636
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.01750511
63Cerebral edema (HP:0002181)2.00617934
64Toxemia of pregnancy (HP:0100603)2.00513363
65Respiratory difficulties (HP:0002880)2.00351635
66Central scotoma (HP:0000603)2.00154443
67Neoplasm of the adrenal gland (HP:0100631)1.99669777
68Abnormality of the preputium (HP:0100587)1.99423509
69True hermaphroditism (HP:0010459)1.99049591
70Thyroiditis (HP:0100646)1.97071304
71Abnormality of urine glucose concentration (HP:0011016)1.96187179
72Glycosuria (HP:0003076)1.96187179
73Hypoproteinemia (HP:0003075)1.92771890
74Hyperglycinemia (HP:0002154)1.90717431
75Abnormality of potassium homeostasis (HP:0011042)1.90184941
76Pancreatic fibrosis (HP:0100732)1.88826883
77Lethargy (HP:0001254)1.86721088
78Progressive inability to walk (HP:0002505)1.86687395
79Type II lissencephaly (HP:0007260)1.83809845
80Muscle fiber atrophy (HP:0100295)1.82676284
81Oral leukoplakia (HP:0002745)1.82145894
82Nephronophthisis (HP:0000090)1.80978320
83Pendular nystagmus (HP:0012043)1.80002582
84Duplicated collecting system (HP:0000081)1.79791010
85Elevated erythrocyte sedimentation rate (HP:0003565)1.78927455
86Hypomagnesemia (HP:0002917)1.77649873
87Attenuation of retinal blood vessels (HP:0007843)1.77326237
88Lactic acidosis (HP:0003128)1.76260763
89Large for gestational age (HP:0001520)1.75774249
90Aplasia/hypoplasia of the uterus (HP:0008684)1.75184846
91Abnormality of incisor morphology (HP:0011063)1.74888661
92Inability to walk (HP:0002540)1.74830326
93Abnormality of the fovea (HP:0000493)1.74305740
94Abolished electroretinogram (ERG) (HP:0000550)1.74266404
95Clubbing of toes (HP:0100760)1.73849544
96Severe combined immunodeficiency (HP:0004430)1.72819355
97Abnormality of serum amino acid levels (HP:0003112)1.71659534
98Aplastic anemia (HP:0001915)1.71397259
99Hyperphosphaturia (HP:0003109)1.70076580
100Exercise intolerance (HP:0003546)1.69798042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.91079920
2EIF2AK33.75243899
3NUAK13.57017812
4MST43.49731360
5EIF2AK13.21936901
6VRK22.84198531
7ZAK2.46360916
8CASK2.46039904
9TAF12.45383240
10MKNK12.32399148
11BUB12.29241399
12TRIM282.06777893
13FRK2.00775899
14MAP2K61.99108049
15ADRBK21.97268430
16WNK31.95071400
17NME11.94391420
18MKNK21.91716373
19TXK1.89110207
20PLK31.87223985
21PBK1.84432608
22SRPK11.84290452
23WNK41.80255837
24EIF2AK21.73137796
25TLK11.55165927
26BMPR1B1.52698987
27VRK11.52205649
28NEK11.49140313
29NME21.36216266
30STK391.33129762
31GRK11.28722478
32DAPK21.27120175
33ALK1.26823450
34TNIK1.25473516
35PLK21.19048369
36MAP4K21.14533051
37NLK1.13311416
38TNK21.11613326
39MAPKAPK51.11070129
40TEC1.09976208
41IRAK41.02251846
42OXSR10.89528304
43FGFR10.83846517
44ACVR1B0.83656213
45PDK20.80956581
46TAOK30.80077892
47PIK3CG0.78659338
48PLK40.78491342
49DAPK10.76732547
50CSNK1G10.67494805
51PRKCQ0.67378204
52TGFBR10.65932237
53DYRK20.65387527
54TIE10.64536506
55CSNK1G20.61770540
56PAK40.61259092
57PLK10.61126444
58CSNK1G30.58490808
59RPS6KA50.57912232
60ATR0.56335578
61MAP3K90.56232799
62IKBKB0.56106595
63PHKG20.55836138
64PHKG10.55836138
65STK40.55364594
66ITK0.54553500
67PAK30.54313007
68BCKDK0.53804658
69CSNK1A1L0.52833070
70SIK30.51621935
71PRKCE0.50854828
72KIT0.50462091
73TTK0.48168074
74PRKCG0.47905660
75MUSK0.44340779
76STK38L0.41832623
77INSRR0.41442926
78ADRBK10.40542600
79PASK0.35719980
80PRKD30.35467278
81IKBKE0.34648633
82STK30.34218758
83CLK10.33722981
84WEE10.33502711
85WNK10.33008004
86CSNK2A20.31094859
87MAP3K140.30942884
88CSNK1E0.30407415
89CHEK10.28809167
90ATM0.26836008
91STK160.26432863
92MAPK130.25454530
93IRAK10.24871299
94JAK30.24653607
95GRK50.24568353
96CSNK2A10.24004828
97RPS6KA40.23449485
98MAP3K120.22901298
99MARK30.22637270
100CAMK2A0.22077710

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.23307300
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.65764795
3Protein export_Homo sapiens_hsa030603.50445131
4Vitamin B6 metabolism_Homo sapiens_hsa007502.74984099
5One carbon pool by folate_Homo sapiens_hsa006702.68878441
6Basal transcription factors_Homo sapiens_hsa030222.67334655
7Asthma_Homo sapiens_hsa053102.54745170
8Allograft rejection_Homo sapiens_hsa053302.34691198
9RNA polymerase_Homo sapiens_hsa030202.23797202
10RNA degradation_Homo sapiens_hsa030182.09217596
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04432554
12Oxidative phosphorylation_Homo sapiens_hsa001902.00089570
13Autoimmune thyroid disease_Homo sapiens_hsa053201.97611713
14Primary immunodeficiency_Homo sapiens_hsa053401.92923283
15Propanoate metabolism_Homo sapiens_hsa006401.85833503
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83422667
17Type I diabetes mellitus_Homo sapiens_hsa049401.79404475
18RNA transport_Homo sapiens_hsa030131.75613670
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.72549539
20Parkinsons disease_Homo sapiens_hsa050121.68127859
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63904870
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60866464
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50384017
24Linoleic acid metabolism_Homo sapiens_hsa005911.44560383
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43653948
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.43621130
27Homologous recombination_Homo sapiens_hsa034401.41743028
28Nucleotide excision repair_Homo sapiens_hsa034201.27469933
29Ribosome_Homo sapiens_hsa030101.26833130
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26532023
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25648165
32Phototransduction_Homo sapiens_hsa047441.18676690
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09453799
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07476708
35Huntingtons disease_Homo sapiens_hsa050161.07016759
36Nitrogen metabolism_Homo sapiens_hsa009101.07014919
37Graft-versus-host disease_Homo sapiens_hsa053321.06758530
38Spliceosome_Homo sapiens_hsa030401.03039743
39Purine metabolism_Homo sapiens_hsa002301.01464259
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01193506
41Sulfur metabolism_Homo sapiens_hsa009200.99993697
42Mismatch repair_Homo sapiens_hsa034300.98881838
43Pyrimidine metabolism_Homo sapiens_hsa002400.98216844
44Non-homologous end-joining_Homo sapiens_hsa034500.97589161
45Caffeine metabolism_Homo sapiens_hsa002320.94977337
46Fanconi anemia pathway_Homo sapiens_hsa034600.92253177
47Ether lipid metabolism_Homo sapiens_hsa005650.91374333
48Peroxisome_Homo sapiens_hsa041460.90419661
49Alzheimers disease_Homo sapiens_hsa050100.89249061
50Steroid biosynthesis_Homo sapiens_hsa001000.88231314
51T cell receptor signaling pathway_Homo sapiens_hsa046600.85901171
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84222471
53Vitamin digestion and absorption_Homo sapiens_hsa049770.84132583
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.83754353
55Hematopoietic cell lineage_Homo sapiens_hsa046400.80043008
56Butanoate metabolism_Homo sapiens_hsa006500.79330638
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.78026894
58Tryptophan metabolism_Homo sapiens_hsa003800.78025811
59Mineral absorption_Homo sapiens_hsa049780.73285186
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71851731
61Glutathione metabolism_Homo sapiens_hsa004800.70544674
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69821035
63Retinol metabolism_Homo sapiens_hsa008300.68330666
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68149111
65Rheumatoid arthritis_Homo sapiens_hsa053230.66211574
66DNA replication_Homo sapiens_hsa030300.65614041
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65086126
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.64582357
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62544871
70Measles_Homo sapiens_hsa051620.62308788
71Antigen processing and presentation_Homo sapiens_hsa046120.62016410
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59420303
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58939138
74Chemical carcinogenesis_Homo sapiens_hsa052040.55775994
75Base excision repair_Homo sapiens_hsa034100.55627118
76Metabolic pathways_Homo sapiens_hsa011000.54973077
77Regulation of autophagy_Homo sapiens_hsa041400.54898465
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52061338
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51315071
80Selenocompound metabolism_Homo sapiens_hsa004500.47669224
81Arginine biosynthesis_Homo sapiens_hsa002200.45524260
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45140480
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.43796075
84Glycerolipid metabolism_Homo sapiens_hsa005610.42984599
85mRNA surveillance pathway_Homo sapiens_hsa030150.42890027
86Fat digestion and absorption_Homo sapiens_hsa049750.42790847
87Folate biosynthesis_Homo sapiens_hsa007900.41902220
88Arachidonic acid metabolism_Homo sapiens_hsa005900.41522294
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.40788718
90Fatty acid degradation_Homo sapiens_hsa000710.38757795
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38220024
92Pyruvate metabolism_Homo sapiens_hsa006200.37670609
93Carbon metabolism_Homo sapiens_hsa012000.36767089
94Circadian rhythm_Homo sapiens_hsa047100.36289118
95TGF-beta signaling pathway_Homo sapiens_hsa043500.36263509
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34400588
97Arginine and proline metabolism_Homo sapiens_hsa003300.33380838
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.32716910
99Epstein-Barr virus infection_Homo sapiens_hsa051690.32425205
100beta-Alanine metabolism_Homo sapiens_hsa004100.32066430

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