NPM1P42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.09758419
2DNA deamination (GO:0045006)5.01706103
3chaperone-mediated protein transport (GO:0072321)4.74264504
4rRNA modification (GO:0000154)4.41104786
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.27437911
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26121474
7positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.24965699
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13643397
9ATP synthesis coupled proton transport (GO:0015986)4.13643397
10cullin deneddylation (GO:0010388)4.02009788
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00460602
12nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.98718715
13regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.98067744
14rRNA methylation (GO:0031167)3.96687361
15protein deneddylation (GO:0000338)3.94380492
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.94190883
17regulation of cellular amino acid metabolic process (GO:0006521)3.91349741
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71459023
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68161745
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.68161745
21NADH dehydrogenase complex assembly (GO:0010257)3.68161745
22negative regulation of ligase activity (GO:0051352)3.62031712
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.62031712
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60967474
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55288685
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.55183530
27signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.51762801
28signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.51762801
29signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.51762801
30maturation of 5.8S rRNA (GO:0000460)3.49342502
31regulation of chronic inflammatory response (GO:0002676)3.46995336
32somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.45709421
33somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.45709421
34isotype switching (GO:0045190)3.45709421
35ribosome assembly (GO:0042255)3.45577172
36regulation of immunoglobulin secretion (GO:0051023)3.44799210
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.44603087
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.44603087
39protein complex biogenesis (GO:0070271)3.44509954
40DNA catabolic process, exonucleolytic (GO:0000738)3.43915276
41DNA double-strand break processing (GO:0000729)3.43355289
42protein neddylation (GO:0045116)3.41810242
43mitochondrial respiratory chain complex assembly (GO:0033108)3.40088177
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.32997349
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.32997349
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32832296
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30370738
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.27359393
49termination of RNA polymerase III transcription (GO:0006386)3.24027669
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.24027669
51water-soluble vitamin biosynthetic process (GO:0042364)3.23588129
52respiratory chain complex IV assembly (GO:0008535)3.20350766
53peptidyl-histidine modification (GO:0018202)3.17473092
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16359907
55regulation of isotype switching to IgG isotypes (GO:0048302)3.16133841
56pseudouridine synthesis (GO:0001522)3.15258507
57RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11841159
58electron transport chain (GO:0022900)3.09071481
59respiratory electron transport chain (GO:0022904)3.07801843
60positive regulation of ligase activity (GO:0051351)3.02850456
61positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.98743700
62synapsis (GO:0007129)2.97559422
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96039391
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96039391
65IMP biosynthetic process (GO:0006188)2.95478443
66ribosomal large subunit biogenesis (GO:0042273)2.89795357
67protein-cofactor linkage (GO:0018065)2.86871692
68intracellular protein transmembrane import (GO:0044743)2.86616461
69rRNA processing (GO:0006364)2.86516683
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.84905862
71mitochondrial RNA metabolic process (GO:0000959)2.83436383
72protein targeting to mitochondrion (GO:0006626)2.81963341
73rRNA metabolic process (GO:0016072)2.81450575
74GTP biosynthetic process (GO:0006183)2.78873302
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76651623
76regulation of mitotic spindle checkpoint (GO:1903504)2.76651623
77preassembly of GPI anchor in ER membrane (GO:0016254)2.75952564
78organelle disassembly (GO:1903008)2.75326064
79regulation of cellular amine metabolic process (GO:0033238)2.75135399
80tRNA processing (GO:0008033)2.72818832
81ribosomal small subunit assembly (GO:0000028)2.72091505
82regulation of ubiquitin-protein transferase activity (GO:0051438)2.71253095
83positive regulation of DNA recombination (GO:0045911)2.70201942
84chromatin remodeling at centromere (GO:0031055)2.69383992
85positive regulation of immunoglobulin mediated immune response (GO:0002891)2.69314612
86positive regulation of B cell mediated immunity (GO:0002714)2.69314612
87positive regulation of cell cycle arrest (GO:0071158)2.69272576
88antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.68912819
89DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.67813797
90positive regulation of interleukin-17 production (GO:0032740)2.67211733
91CENP-A containing nucleosome assembly (GO:0034080)2.66799642
92positive regulation of isotype switching (GO:0045830)2.65790183
93mannosylation (GO:0097502)2.64165212
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62947282
95establishment of protein localization to mitochondrion (GO:0072655)2.62515213
96negative regulation of DNA-dependent DNA replication (GO:2000104)2.62424554
97cytochrome complex assembly (GO:0017004)2.62004245
98regulation of ligase activity (GO:0051340)2.61871544
99aldehyde catabolic process (GO:0046185)2.61392879
100nucleobase biosynthetic process (GO:0046112)2.59766362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.91082673
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.36864841
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.97222150
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.86637932
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05500538
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00175523
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88053217
8VDR_23849224_ChIP-Seq_CD4+_Human2.82366975
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.66907873
10ELK1_19687146_ChIP-ChIP_HELA_Human2.62030305
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.57094126
12VDR_22108803_ChIP-Seq_LS180_Human2.55947207
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48850643
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42857577
15ZNF274_21170338_ChIP-Seq_K562_Hela2.39155343
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37304303
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.32211444
18FOXP3_21729870_ChIP-Seq_TREG_Human2.31346121
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18955424
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16226819
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.08339061
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00431592
23EWS_26573619_Chip-Seq_HEK293_Human1.98421544
24IGF1R_20145208_ChIP-Seq_DFB_Human1.95442463
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86340004
26MYC_18940864_ChIP-ChIP_HL60_Human1.76939322
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76178373
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69230075
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62707373
30FUS_26573619_Chip-Seq_HEK293_Human1.62542662
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.60497888
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55254163
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55226844
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53580034
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52464150
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51765640
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51623337
38DCP1A_22483619_ChIP-Seq_HELA_Human1.45741424
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45490812
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44885784
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43693794
42E2F7_22180533_ChIP-Seq_HELA_Human1.42996847
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39963261
44TTF2_22483619_ChIP-Seq_HELA_Human1.38726818
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38265183
46TAF15_26573619_Chip-Seq_HEK293_Human1.37898170
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37600174
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.37600174
49GABP_19822575_ChIP-Seq_HepG2_Human1.34606250
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29764729
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28511110
52GATA3_26560356_Chip-Seq_TH2_Human1.27817157
53TP53_22573176_ChIP-Seq_HFKS_Human1.27810873
54ER_23166858_ChIP-Seq_MCF-7_Human1.27286763
55P300_19829295_ChIP-Seq_ESCs_Human1.26248986
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26107318
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23731453
58SOX2_19829295_ChIP-Seq_ESCs_Human1.23115986
59NANOG_19829295_ChIP-Seq_ESCs_Human1.23115986
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22135732
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21869805
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.21395509
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.20530667
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17509818
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.17472372
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16716216
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12845538
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12796129
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11706812
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09243658
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08454719
72AR_20517297_ChIP-Seq_VCAP_Human1.07481505
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05748849
74IRF1_19129219_ChIP-ChIP_H3396_Human1.05196252
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03610833
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.00200380
77ERG_20517297_ChIP-Seq_VCAP_Human0.98833670
78FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98555331
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97176874
80CRX_20693478_ChIP-Seq_RETINA_Mouse0.97004306
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96381972
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96355796
83BP1_19119308_ChIP-ChIP_Hs578T_Human0.95315880
84GATA3_21878914_ChIP-Seq_MCF-7_Human0.94526764
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93593989
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93092815
87GATA1_22025678_ChIP-Seq_K562_Human0.92907113
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92125892
89CBP_20019798_ChIP-Seq_JUKART_Human0.91653670
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91653670
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91204958
92IRF8_22096565_ChIP-ChIP_GC-B_Human0.90786682
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90345337
94HOXB7_26014856_ChIP-Seq_BT474_Human0.89608274
95THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88043875
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87969427
97MYB_26560356_Chip-Seq_TH2_Human0.87954830
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87822416
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87210937
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86748528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.55203665
2MP0008877_abnormal_DNA_methylation3.30786209
3MP0002102_abnormal_ear_morphology2.93354356
4MP0005671_abnormal_response_to2.91374566
5MP0008058_abnormal_DNA_repair2.59697291
6MP0003786_premature_aging2.45356749
7MP0005075_abnormal_melanosome_morpholog2.40536842
8MP0003718_maternal_effect2.40439425
9MP0008875_abnormal_xenobiotic_pharmacok2.39035547
10MP0006072_abnormal_retinal_apoptosis2.38449531
11MP0008872_abnormal_physiological_respon2.24999592
12MP0010094_abnormal_chromosome_stability2.21188631
13MP0004147_increased_porphyrin_level2.13148553
14MP0003195_calcinosis2.04530846
15MP0003806_abnormal_nucleotide_metabolis2.04187496
16MP0002148_abnormal_hypersensitivity_rea2.00726442
17MP0000685_abnormal_immune_system1.98007433
18MP0006292_abnormal_olfactory_placode1.89476132
19MP0006036_abnormal_mitochondrial_physio1.83420327
20MP0005084_abnormal_gallbladder_morpholo1.76167432
21MP0001873_stomach_inflammation1.75810155
22MP0003646_muscle_fatigue1.74249963
23MP0003693_abnormal_embryo_hatching1.72737129
24MP0006035_abnormal_mitochondrial_morpho1.68231654
25MP0002736_abnormal_nociception_after1.66586088
26MP0004957_abnormal_blastocyst_morpholog1.64641836
27MP0000372_irregular_coat_pigmentation1.59490684
28MP0008007_abnormal_cellular_replicative1.56994087
29MP0001968_abnormal_touch/_nociception1.51028751
30MP0001501_abnormal_sleep_pattern1.48388482
31MP0001293_anophthalmia1.46149665
32MP0001800_abnormal_humoral_immune1.46083198
33MP0002876_abnormal_thyroid_physiology1.44000785
34MP0002006_tumorigenesis1.43904522
35MP0008057_abnormal_DNA_replication1.43829094
36MP0009785_altered_susceptibility_to1.43440191
37MP0005646_abnormal_pituitary_gland1.42886657
38MP0009333_abnormal_splenocyte_physiolog1.42414724
39MP0009697_abnormal_copulation1.40553397
40MP0005389_reproductive_system_phenotype1.40213876
41MP0005551_abnormal_eye_electrophysiolog1.36589393
42MP0002163_abnormal_gland_morphology1.34353558
43MP0002160_abnormal_reproductive_system1.34239773
44MP0002837_dystrophic_cardiac_calcinosis1.31939820
45MP0002938_white_spotting1.26245430
46MP0002138_abnormal_hepatobiliary_system1.26037414
47MP0001790_abnormal_immune_system1.24683619
48MP0005387_immune_system_phenotype1.24683619
49MP0001986_abnormal_taste_sensitivity1.24256773
50MP0008995_early_reproductive_senescence1.21709076
51MP0003186_abnormal_redox_activity1.21548291
52MP0005253_abnormal_eye_physiology1.21309277
53MP0003136_yellow_coat_color1.19595360
54MP0004145_abnormal_muscle_electrophysio1.15833533
55MP0005000_abnormal_immune_tolerance1.14676407
56MP0005408_hypopigmentation1.09186719
57MP0001919_abnormal_reproductive_system1.08626571
58MP0002166_altered_tumor_susceptibility1.06862940
59MP0005645_abnormal_hypothalamus_physiol1.06502534
60MP0003763_abnormal_thymus_physiology1.04692481
61MP0001853_heart_inflammation1.04391042
62MP0009764_decreased_sensitivity_to1.03959659
63MP0001984_abnormal_olfaction1.02718776
64MP0002723_abnormal_immune_serum1.02352884
65MP0000465_gastrointestinal_hemorrhage1.02164578
66MP0003011_delayed_dark_adaptation1.01234855
67MP0004885_abnormal_endolymph0.99166982
68MP0005377_hearing/vestibular/ear_phenot0.98216247
69MP0003878_abnormal_ear_physiology0.98216247
70MP0001119_abnormal_female_reproductive0.96161767
71MP0002452_abnormal_antigen_presenting0.95544758
72MP0003567_abnormal_fetal_cardiomyocyte0.95033847
73MP0000689_abnormal_spleen_morphology0.93655685
74MP0003787_abnormal_imprinting0.93622015
75MP0002420_abnormal_adaptive_immunity0.93502094
76MP0001529_abnormal_vocalization0.93379011
77MP0001819_abnormal_immune_cell0.92600368
78MP0005379_endocrine/exocrine_gland_phen0.91678121
79MP0004142_abnormal_muscle_tone0.91570412
80MP0003077_abnormal_cell_cycle0.90997390
81MP0001188_hyperpigmentation0.90372768
82MP0003866_abnormal_defecation0.88199883
83MP0000383_abnormal_hair_follicle0.86569546
84MP0005310_abnormal_salivary_gland0.86030612
85MP0004782_abnormal_surfactant_physiolog0.84985478
86MP0002398_abnormal_bone_marrow0.82699690
87MP0000427_abnormal_hair_cycle0.81069135
88MP0002210_abnormal_sex_determination0.80611056
89MP0001905_abnormal_dopamine_level0.80073001
90MP0004215_abnormal_myocardial_fiber0.79661274
91MP0000703_abnormal_thymus_morphology0.78841754
92MP0010307_abnormal_tumor_latency0.78630922
93MP0001929_abnormal_gametogenesis0.77198286
94MP0003724_increased_susceptibility_to0.77008112
95MP0005636_abnormal_mineral_homeostasis0.76500787
96MP0005085_abnormal_gallbladder_physiolo0.75979481
97MP0005332_abnormal_amino_acid0.75057077
98MP0001485_abnormal_pinna_reflex0.74604188
99MP0003111_abnormal_nucleus_morphology0.74556720
100MP0000716_abnormal_immune_system0.74203011

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.57645176
2Increased CSF lactate (HP:0002490)4.07074277
3Mitochondrial inheritance (HP:0001427)4.03364341
4Acute necrotizing encephalopathy (HP:0006965)4.01205162
5Lipid accumulation in hepatocytes (HP:0006561)3.82264813
6Increased hepatocellular lipid droplets (HP:0006565)3.70249575
7IgG deficiency (HP:0004315)3.64672653
8Acute encephalopathy (HP:0006846)3.64637749
9Hepatocellular necrosis (HP:0001404)3.64585990
10Abnormal mitochondria in muscle tissue (HP:0008316)3.42881328
11Progressive macrocephaly (HP:0004481)3.42495921
12Hepatic necrosis (HP:0002605)3.36914075
13Abnormality of alanine metabolism (HP:0010916)3.21750710
14Hyperalaninemia (HP:0003348)3.21750710
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.21750710
16Increased serum lactate (HP:0002151)3.05213170
173-Methylglutaconic aciduria (HP:0003535)2.98778999
18Elevated erythrocyte sedimentation rate (HP:0003565)2.84420260
19Methylmalonic acidemia (HP:0002912)2.74782564
20Pancreatic cysts (HP:0001737)2.74455050
21Cerebral edema (HP:0002181)2.69216242
22Lactic acidosis (HP:0003128)2.68672664
23Congenital stationary night blindness (HP:0007642)2.64922541
24Renal Fanconi syndrome (HP:0001994)2.52210606
25Optic disc pallor (HP:0000543)2.51965812
26Nephronophthisis (HP:0000090)2.50660049
27Congenital, generalized hypertrichosis (HP:0004540)2.48465584
28Methylmalonic aciduria (HP:0012120)2.45745381
29Supernumerary spleens (HP:0009799)2.44443401
30Exertional dyspnea (HP:0002875)2.43352721
31Increased intramyocellular lipid droplets (HP:0012240)2.39489375
32Abolished electroretinogram (ERG) (HP:0000550)2.33533514
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32583674
34Abnormality of B cell number (HP:0010975)2.31164041
35Respiratory failure (HP:0002878)2.31115459
36Type I transferrin isoform profile (HP:0003642)2.28941727
37Lethargy (HP:0001254)2.25381756
38Molar tooth sign on MRI (HP:0002419)2.24065631
39Abnormality of midbrain morphology (HP:0002418)2.24065631
40CNS demyelination (HP:0007305)2.22595056
41Abnormality of the pons (HP:0007361)2.21763502
42B lymphocytopenia (HP:0010976)2.19982632
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19103147
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19103147
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16741194
46Increased muscle lipid content (HP:0009058)2.16524243
47Abnormality of T cells (HP:0002843)2.15626681
48Abnormality of the labia minora (HP:0012880)2.14264425
49Duplicated collecting system (HP:0000081)2.14215766
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14081826
51True hermaphroditism (HP:0010459)2.13699498
52Colon cancer (HP:0003003)2.13433507
53Abnormal rod and cone electroretinograms (HP:0008323)2.12653060
54Hyperglycinuria (HP:0003108)2.12515403
55Abnormality of T cell physiology (HP:0011840)2.12106515
56Pancreatic fibrosis (HP:0100732)2.12015011
57Abnormality of urine glucose concentration (HP:0011016)2.09719675
58Glycosuria (HP:0003076)2.09719675
59Hypoproteinemia (HP:0003075)2.09142522
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.06265408
61Hypoplasia of the fovea (HP:0007750)2.06265408
62Constricted visual fields (HP:0001133)2.06102862
63Severe combined immunodeficiency (HP:0004430)2.03087730
64Abnormality of the renal collecting system (HP:0004742)2.03066471
65Abnormality of the ileum (HP:0001549)2.02774318
66Respiratory difficulties (HP:0002880)2.02713372
67Type 2 muscle fiber atrophy (HP:0003554)2.02571293
68Pancytopenia (HP:0001876)1.99555727
69Leukodystrophy (HP:0002415)1.98414515
70Abnormality of serum amino acid levels (HP:0003112)1.97333040
71Meckel diverticulum (HP:0002245)1.96540546
72Increased IgM level (HP:0003496)1.94903779
73Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94531162
74Exercise intolerance (HP:0003546)1.93959016
75Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93311620
76Hypoplasia of the pons (HP:0012110)1.93311435
77Aplasia/hypoplasia of the uterus (HP:0008684)1.90845983
78Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88528413
79Testicular atrophy (HP:0000029)1.88433202
80Reduced antithrombin III activity (HP:0001976)1.88305094
81Thyroiditis (HP:0100646)1.87668095
82Abnormality of the renal medulla (HP:0100957)1.87503298
83Abnormality of the prostate (HP:0008775)1.86722687
84Abnormal biliary tract physiology (HP:0012439)1.84419142
85Bile duct proliferation (HP:0001408)1.84419142
86Large for gestational age (HP:0001520)1.84239994
87Increased serum pyruvate (HP:0003542)1.83441594
88Attenuation of retinal blood vessels (HP:0007843)1.81986606
89Abnormality of T cell number (HP:0011839)1.81589107
90Abnormal spermatogenesis (HP:0008669)1.81514119
91T lymphocytopenia (HP:0005403)1.81455066
92Abnormal protein glycosylation (HP:0012346)1.80192062
93Abnormal glycosylation (HP:0012345)1.80192062
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80192062
95Abnormal protein N-linked glycosylation (HP:0012347)1.80192062
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.79925395
97Chromsome breakage (HP:0040012)1.79449226
98Hyperglycinemia (HP:0002154)1.73296192
99Abnormality of macular pigmentation (HP:0008002)1.72589209
100IgM deficiency (HP:0002850)1.72539221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.51930344
2VRK23.06409103
3NUAK13.00352230
4ZAK2.96668653
5EIF2AK32.96616458
6MST42.87859742
7TSSK62.75686862
8TRIM282.61361491
9BUB12.40422592
10PBK2.34564924
11EIF2AK12.32193649
12TLK12.29675575
13NME12.25088621
14ADRBK22.22774289
15MKNK22.11428703
16GRK12.07466210
17PLK31.95504273
18FRK1.85002981
19STK391.83403032
20MKNK11.81694072
21SRPK11.73088282
22STK161.69221014
23VRK11.63787822
24EIF2AK21.61193134
25OXSR11.60679551
26PLK41.45223115
27WNK41.35332435
28TAOK31.33985980
29BCKDK1.32178522
30MAP4K21.29087228
31TAF11.26244833
32NEK11.24752576
33SCYL21.24435795
34ACVR1B1.20538285
35MAP3K121.16044049
36TEC1.12979569
37WNK31.08765450
38BMPR1B1.04507856
39PLK21.03967670
40BMPR21.03305394
41ERBB31.01153961
42PASK0.96677527
43KIT0.93403787
44IKBKB0.92756708
45PDK20.91430982
46TNIK0.90842992
47CSNK1G30.88378284
48ALK0.88208000
49CSNK1G10.86315399
50DAPK10.86173390
51CSNK1A1L0.83521072
52BRSK20.81149523
53DAPK20.76686384
54PLK10.71875943
55ITK0.71840379
56PINK10.71499795
57WEE10.68339491
58BCR0.67845130
59PHKG10.66279426
60PHKG20.66279426
61ATR0.65394261
62TTK0.64001720
63MAP2K60.63268286
64INSRR0.61128404
65TIE10.56712235
66CDC70.56377428
67CSNK1G20.55068792
68RPS6KA50.51644124
69CAMKK20.51124982
70STK38L0.49060740
71PRKCG0.48406553
72MYLK0.47401404
73MAP4K10.47027844
74FES0.46151809
75MAP3K140.45664931
76NLK0.45505807
77PRKCE0.45239689
78CCNB10.44801346
79AURKB0.44701588
80PRKCI0.43706228
81CSNK2A10.43153085
82MAP3K40.42346199
83PRKCQ0.42241088
84MAPKAPK30.41258373
85LCK0.41164584
86IKBKE0.39878393
87CSNK2A20.39108067
88DYRK20.38677394
89GRK50.38562295
90FLT30.36549761
91GRK60.36466043
92SYK0.36243570
93ADRBK10.35879553
94CDK30.34999941
95IGF1R0.34892449
96TGFBR10.32088366
97NME20.30238449
98STK30.28053136
99ATM0.27470524
100LYN0.25452813

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.92933696
2Asthma_Homo sapiens_hsa053102.96450741
3Oxidative phosphorylation_Homo sapiens_hsa001902.94406298
4Protein export_Homo sapiens_hsa030602.90737404
5RNA polymerase_Homo sapiens_hsa030202.63033065
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56517455
7Parkinsons disease_Homo sapiens_hsa050122.40527321
8Allograft rejection_Homo sapiens_hsa053302.31807163
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.24508870
10Ribosome_Homo sapiens_hsa030102.16587760
11Homologous recombination_Homo sapiens_hsa034402.10151516
12Autoimmune thyroid disease_Homo sapiens_hsa053202.08630859
13Mismatch repair_Homo sapiens_hsa034301.99978537
14DNA replication_Homo sapiens_hsa030301.91792218
15One carbon pool by folate_Homo sapiens_hsa006701.87634439
16RNA degradation_Homo sapiens_hsa030181.86504194
17Basal transcription factors_Homo sapiens_hsa030221.85953847
18Type I diabetes mellitus_Homo sapiens_hsa049401.85587424
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77321289
20Propanoate metabolism_Homo sapiens_hsa006401.75374858
21RNA transport_Homo sapiens_hsa030131.63366886
22Graft-versus-host disease_Homo sapiens_hsa053321.62991686
23Primary immunodeficiency_Homo sapiens_hsa053401.60822634
24Huntingtons disease_Homo sapiens_hsa050161.55486595
25Non-homologous end-joining_Homo sapiens_hsa034501.52544945
26Fanconi anemia pathway_Homo sapiens_hsa034601.46659909
27Alzheimers disease_Homo sapiens_hsa050101.43044210
28Pyrimidine metabolism_Homo sapiens_hsa002401.39436609
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37286663
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36798222
31Nucleotide excision repair_Homo sapiens_hsa034201.36387950
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30537964
33Base excision repair_Homo sapiens_hsa034101.29619855
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28350888
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27631409
36Spliceosome_Homo sapiens_hsa030401.27032791
37Sulfur metabolism_Homo sapiens_hsa009201.23654845
38Purine metabolism_Homo sapiens_hsa002301.23417822
39Linoleic acid metabolism_Homo sapiens_hsa005911.17790631
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17328104
41Antigen processing and presentation_Homo sapiens_hsa046121.13004950
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.12109700
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12089280
44Rheumatoid arthritis_Homo sapiens_hsa053231.09354274
45Fatty acid elongation_Homo sapiens_hsa000621.04272280
46Vitamin B6 metabolism_Homo sapiens_hsa007501.02981484
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01482119
48Phototransduction_Homo sapiens_hsa047440.98988293
49Caffeine metabolism_Homo sapiens_hsa002320.95778665
50Peroxisome_Homo sapiens_hsa041460.94014600
51Tryptophan metabolism_Homo sapiens_hsa003800.92278125
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87435375
53Hematopoietic cell lineage_Homo sapiens_hsa046400.81287005
54Butanoate metabolism_Homo sapiens_hsa006500.80775364
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74718032
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71403519
57Pyruvate metabolism_Homo sapiens_hsa006200.70316318
58Nitrogen metabolism_Homo sapiens_hsa009100.69021207
59Collecting duct acid secretion_Homo sapiens_hsa049660.68355314
60Cardiac muscle contraction_Homo sapiens_hsa042600.68121373
61Metabolic pathways_Homo sapiens_hsa011000.62600570
62Selenocompound metabolism_Homo sapiens_hsa004500.62480050
63Regulation of autophagy_Homo sapiens_hsa041400.61654049
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61205980
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.61076383
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60103372
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57567289
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56849284
69Ether lipid metabolism_Homo sapiens_hsa005650.56718989
70Folate biosynthesis_Homo sapiens_hsa007900.55295871
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54890715
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54643096
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53973824
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53032667
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52950013
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52441550
77p53 signaling pathway_Homo sapiens_hsa041150.52256234
78Retinol metabolism_Homo sapiens_hsa008300.50079242
79Chemical carcinogenesis_Homo sapiens_hsa052040.49792194
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.49093221
81Epstein-Barr virus infection_Homo sapiens_hsa051690.48024708
82Arachidonic acid metabolism_Homo sapiens_hsa005900.45987996
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44841328
84Glutathione metabolism_Homo sapiens_hsa004800.44340007
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42968770
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42936836
87beta-Alanine metabolism_Homo sapiens_hsa004100.41803110
88T cell receptor signaling pathway_Homo sapiens_hsa046600.41670056
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.38540157
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.38108738
91Fat digestion and absorption_Homo sapiens_hsa049750.37924421
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.37381667
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35721347
94Vitamin digestion and absorption_Homo sapiens_hsa049770.34265932
95Herpes simplex infection_Homo sapiens_hsa051680.31994246
96Systemic lupus erythematosus_Homo sapiens_hsa053220.31945921
97Fatty acid degradation_Homo sapiens_hsa000710.30720336
98Measles_Homo sapiens_hsa051620.30549643
99Olfactory transduction_Homo sapiens_hsa047400.28230397
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.25532121

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