NPM1P43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)8.85596149
2regulation of regulatory T cell differentiation (GO:0045589)8.55719544
3tolerance induction (GO:0002507)7.81859934
4phenylpropanoid metabolic process (GO:0009698)6.84641234
5regulation of interleukin-2 biosynthetic process (GO:0045076)6.57966969
6ribosomal small subunit assembly (GO:0000028)6.12207984
7regulation of odontogenesis of dentin-containing tooth (GO:0042487)6.03308890
8negative regulation of calcium ion transport into cytosol (GO:0010523)5.48545741
9negative regulation of interleukin-2 production (GO:0032703)5.31281562
10positive regulation of tolerance induction (GO:0002645)5.22938191
11ribosomal small subunit biogenesis (GO:0042274)5.21589568
12regulation of immunoglobulin secretion (GO:0051023)5.12627439
13flavonoid metabolic process (GO:0009812)4.95375055
14regulation of transforming growth factor beta1 production (GO:0032908)4.95133658
15regulation of chronic inflammatory response (GO:0002676)4.88130086
16regulation of interleukin-5 production (GO:0032674)4.79255588
17regulation of T cell tolerance induction (GO:0002664)4.70625748
18negative regulation of interleukin-10 production (GO:0032693)4.65527846
19viral transcription (GO:0019083)4.61757619
20cullin deneddylation (GO:0010388)4.58290929
21translational termination (GO:0006415)4.54247838
22positive regulation of keratinocyte differentiation (GO:0045618)4.53663789
23pre-miRNA processing (GO:0031054)4.50934001
24negative regulation of keratinocyte proliferation (GO:0010839)4.45948715
25positive regulation of T cell differentiation in thymus (GO:0033089)4.38627959
26positive regulation of defense response to virus by host (GO:0002230)4.35987977
27regulation of isotype switching (GO:0045191)4.34578153
28protein deneddylation (GO:0000338)4.29114526
29positive regulation of interleukin-17 production (GO:0032740)4.28987381
30protein K6-linked ubiquitination (GO:0085020)4.20600562
31negative regulation of B cell mediated immunity (GO:0002713)4.09925710
32negative regulation of immunoglobulin mediated immune response (GO:0002890)4.09925710
33signal peptide processing (GO:0006465)4.08603367
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.08357496
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.00723776
36protein targeting to ER (GO:0045047)4.00077922
37cotranslational protein targeting to membrane (GO:0006613)3.97550309
38protein neddylation (GO:0045116)3.88936285
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.88095894
40intestinal epithelial cell development (GO:0060576)3.85271836
41CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.84862684
42negative regulation of glial cell proliferation (GO:0060253)3.84431368
43positive regulation of DNA recombination (GO:0045911)3.81511685
44negative regulation of T cell mediated immunity (GO:0002710)3.78772379
45positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.77455561
46protein localization to endoplasmic reticulum (GO:0070972)3.76009695
47translational elongation (GO:0006414)3.75799632
48regulation of immunoglobulin production (GO:0002637)3.70795839
49CD4-positive, alpha-beta T cell activation (GO:0035710)3.68923774
50response to interleukin-15 (GO:0070672)3.63301556
51cellular response to interleukin-15 (GO:0071350)3.62363813
52regulation of tolerance induction (GO:0002643)3.60388459
53positive regulation of protein oligomerization (GO:0032461)3.60273937
54translational initiation (GO:0006413)3.59385615
55positive regulation of alpha-beta T cell proliferation (GO:0046641)3.57269606
56negative regulation of fatty acid metabolic process (GO:0045922)3.56034376
57negative regulation of histone acetylation (GO:0035067)3.55206754
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53276618
59alpha-beta T cell differentiation (GO:0046632)3.52143544
60SMAD protein complex assembly (GO:0007183)3.50553352
61myeloid dendritic cell differentiation (GO:0043011)3.48503395
62viral life cycle (GO:0019058)3.42054714
63cellular protein complex disassembly (GO:0043624)3.41354924
64regulation of glial cell proliferation (GO:0060251)3.38675127
65positive regulation of isotype switching (GO:0045830)3.37265772
66regulation of vitamin D biosynthetic process (GO:0060556)3.34232558
67negative regulation of neurotransmitter secretion (GO:0046929)3.32927983
68regulation of memory T cell differentiation (GO:0043380)3.32807149
69negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.30981061
70regulation of interleukin-2 production (GO:0032663)3.26271548
71negative regulation of DNA recombination (GO:0045910)3.23406821
72histone H2B ubiquitination (GO:0033523)3.22602751
73negative regulation of B cell activation (GO:0050869)3.20131067
74regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.19922099
75cell fate commitment involved in formation of primary germ layer (GO:0060795)3.14740259
76positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.14180984
77regulation of alpha-beta T cell proliferation (GO:0046640)3.11586578
78myeloid dendritic cell activation (GO:0001773)3.10976122
79positive regulation of interleukin-4 production (GO:0032753)3.10355125
80regulation of odontogenesis (GO:0042481)3.09398965
81cellular glucuronidation (GO:0052695)3.08407612
82DNA deamination (GO:0045006)3.08209422
83alpha-beta T cell activation (GO:0046631)3.06131202
84cellular response to dsRNA (GO:0071359)3.05774886
85mature B cell differentiation involved in immune response (GO:0002313)3.04446084
86glucuronate metabolic process (GO:0019585)3.03895759
87uronic acid metabolic process (GO:0006063)3.03895759
88regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.00962753
89translation (GO:0006412)2.98652954
90nerve growth factor signaling pathway (GO:0038180)2.98571120
91protein complex disassembly (GO:0043241)2.96037621
92inner ear receptor cell development (GO:0060119)2.95922639
93positive regulation of immunoglobulin production (GO:0002639)2.95783512
94positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.92156226
95regulation of apoptotic process involved in morphogenesis (GO:1902337)2.91704656
96positive regulation of epidermal cell differentiation (GO:0045606)2.89918663
97negative thymic T cell selection (GO:0045060)2.88354740
98positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.87608801
99rRNA methylation (GO:0031167)2.87464894
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.83806516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.61385646
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.89043716
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.63674478
4GATA1_22025678_ChIP-Seq_K562_Human3.43115983
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09379031
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.94871306
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.84443280
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.83725193
9RUNX_20019798_ChIP-Seq_JUKART_Human2.76665890
10VDR_22108803_ChIP-Seq_LS180_Human2.75014224
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69655508
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68397550
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62809208
14MYB_26560356_Chip-Seq_TH2_Human2.54889540
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.49846751
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49232036
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45011251
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.40479003
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33172434
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.20469437
21VDR_23849224_ChIP-Seq_CD4+_Human2.11171203
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09214218
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99185557
24TAF15_26573619_Chip-Seq_HEK293_Human1.97119933
25EWS_26573619_Chip-Seq_HEK293_Human1.93130060
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89599822
27ELK1_19687146_ChIP-ChIP_HELA_Human1.81835558
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.81354522
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76571814
30FOXP3_21729870_ChIP-Seq_TREG_Human1.73909049
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73616571
32MYB_26560356_Chip-Seq_TH1_Human1.72778927
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72706279
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.70964379
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59064565
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.52680099
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51575741
38MYC_18940864_ChIP-ChIP_HL60_Human1.45314636
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43723292
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43251094
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38753555
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.36963284
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35582808
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35242972
45FUS_26573619_Chip-Seq_HEK293_Human1.32994348
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.32166480
47GATA3_26560356_Chip-Seq_TH2_Human1.29508469
48MAF_26560356_Chip-Seq_TH2_Human1.28952276
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.28229912
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25564917
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25564917
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25564917
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.24166142
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22972536
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22414199
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.21790037
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21739318
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20136446
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17458915
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16342624
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13103673
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12852632
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12615736
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10451718
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07904074
66DCP1A_22483619_ChIP-Seq_HELA_Human1.07712639
67MAF_26560356_Chip-Seq_TH1_Human1.04073656
68TTF2_22483619_ChIP-Seq_HELA_Human1.03624674
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02292321
70HTT_18923047_ChIP-ChIP_STHdh_Human1.01522721
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01476271
72P300_18555785_Chip-Seq_ESCs_Mouse0.99773314
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99495579
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97124056
75E2F1_18555785_Chip-Seq_ESCs_Mouse0.96735103
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96591340
77OCT4_18555785_Chip-Seq_ESCs_Mouse0.96528761
78HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96425858
79THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94431928
80P53_22387025_ChIP-Seq_ESCs_Mouse0.92887537
81SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90162937
82WT1_19549856_ChIP-ChIP_CCG9911_Human0.89085524
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88159159
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87489453
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87360341
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87189644
87CMYC_18555785_Chip-Seq_ESCs_Mouse0.86672260
88NMYC_18555785_Chip-Seq_ESCs_Mouse0.85941930
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85630328
90ELF5_23300383_ChIP-Seq_T47D_Human0.85498926
91SOX2_18555785_Chip-Seq_ESCs_Mouse0.84534251
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83687169
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82407504
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81371602
95SOX9_26525672_Chip-Seq_HEART_Mouse0.80031057
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79635388
97MYC_18358816_ChIP-ChIP_MESCs_Mouse0.78600391
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.78151260
99SMAD1_18555785_Chip-Seq_ESCs_Mouse0.77794708
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.77770124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer7.58186934
2MP0002138_abnormal_hepatobiliary_system7.10416864
3MP0008057_abnormal_DNA_replication5.00728536
4MP0001873_stomach_inflammation4.85726205
5MP0003315_abnormal_perineum_morphology3.78949912
6MP0002277_abnormal_respiratory_mucosa2.65215082
7MP0002876_abnormal_thyroid_physiology2.55735065
8MP0002877_abnormal_melanocyte_morpholog2.33010780
9MP0003878_abnormal_ear_physiology1.98600338
10MP0005377_hearing/vestibular/ear_phenot1.98600338
11MP0005671_abnormal_response_to1.98374782
12MP0009333_abnormal_splenocyte_physiolog1.94558201
13MP0004957_abnormal_blastocyst_morpholog1.86119698
14MP0003763_abnormal_thymus_physiology1.85096948
15MP0003045_fibrosis1.80690686
16MP0000490_abnormal_crypts_of1.79619760
17MP0000703_abnormal_thymus_morphology1.77202122
18MP0010368_abnormal_lymphatic_system1.74566623
19MP0005387_immune_system_phenotype1.73142710
20MP0001790_abnormal_immune_system1.73142710
21MP0001835_abnormal_antigen_presentation1.59233149
22MP0004885_abnormal_endolymph1.56759056
23MP0001853_heart_inflammation1.55362443
24MP0002933_joint_inflammation1.53884162
25MP0001879_abnormal_lymphatic_vessel1.50058676
26MP0000383_abnormal_hair_follicle1.47678442
27MP0008007_abnormal_cellular_replicative1.47259811
28MP0000465_gastrointestinal_hemorrhage1.45430203
29MP0004134_abnormal_chest_morphology1.33281582
30MP0002751_abnormal_autonomic_nervous1.32456783
31MP0003866_abnormal_defecation1.30467745
32MP0001348_abnormal_lacrimal_gland1.27756736
33MP0003868_abnormal_feces_composition1.26818804
34MP0002009_preneoplasia1.23772145
35MP0005408_hypopigmentation1.19854544
36MP0002722_abnormal_immune_system1.18801511
37MP0003693_abnormal_embryo_hatching1.17948751
38MP0001800_abnormal_humoral_immune1.16629652
39MP0003705_abnormal_hypodermis_morpholog1.16121314
40MP0002405_respiratory_system_inflammati1.14937666
41MP0002398_abnormal_bone_marrow1.14118211
42MP0000689_abnormal_spleen_morphology1.13602305
43MP0003567_abnormal_fetal_cardiomyocyte1.13445041
44MP0002166_altered_tumor_susceptibility1.12782509
45MP0002928_abnormal_bile_duct1.12717520
46MP0008058_abnormal_DNA_repair1.11755017
47MP0000678_abnormal_parathyroid_gland1.10071108
48MP0005379_endocrine/exocrine_gland_phen1.10005108
49MP0000537_abnormal_urethra_morphology1.06992189
50MP0003937_abnormal_limbs/digits/tail_de1.06635480
51MP0004947_skin_inflammation1.04071336
52MP0000377_abnormal_hair_follicle1.04056883
53MP0008932_abnormal_embryonic_tissue1.02381580
54MP0000685_abnormal_immune_system1.01828932
55MP0000716_abnormal_immune_system1.00746760
56MP0002420_abnormal_adaptive_immunity1.00372844
57MP0002006_tumorigenesis0.99469245
58MP0005451_abnormal_body_composition0.98087919
59MP0001529_abnormal_vocalization0.97240800
60MP0001727_abnormal_embryo_implantation0.96519487
61MP0001666_abnormal_nutrient_absorption0.95621207
62MP0003077_abnormal_cell_cycle0.93506679
63MP0002723_abnormal_immune_serum0.92501359
64MP0005000_abnormal_immune_tolerance0.92311402
65MP0001819_abnormal_immune_cell0.91411064
66MP0010678_abnormal_skin_adnexa0.89823619
67MP0010155_abnormal_intestine_physiology0.88866849
68MP0002098_abnormal_vibrissa_morphology0.88731243
69MP0002638_abnormal_pupillary_reflex0.83832467
70MP0003252_abnormal_bile_duct0.83377868
71MP0005386_behavior/neurological_phenoty0.81308290
72MP0004924_abnormal_behavior0.81308290
73MP0005367_renal/urinary_system_phenotyp0.81186448
74MP0000516_abnormal_urinary_system0.81186448
75MP0006072_abnormal_retinal_apoptosis0.80920780
76MP0003943_abnormal_hepatobiliary_system0.80002036
77MP0009053_abnormal_anal_canal0.79212818
78MP0009250_abnormal_appendicular_skeleto0.78301865
79MP0003936_abnormal_reproductive_system0.76959147
80MP0002148_abnormal_hypersensitivity_rea0.75897911
81MP0001216_abnormal_epidermal_layer0.75434746
82MP0002429_abnormal_blood_cell0.74917232
83MP0003718_maternal_effect0.74519730
84MP0001243_abnormal_dermal_layer0.72206835
85MP0002452_abnormal_antigen_presenting0.68544090
86MP0001663_abnormal_digestive_system0.67032621
87MP0001340_abnormal_eyelid_morphology0.66298109
88MP0008877_abnormal_DNA_methylation0.66024898
89MP0005310_abnormal_salivary_gland0.65392427
90MP0000372_irregular_coat_pigmentation0.64626153
91MP0001851_eye_inflammation0.64492193
92MP0002095_abnormal_skin_pigmentation0.63814117
93MP0008569_lethality_at_weaning0.62911456
94MP0010094_abnormal_chromosome_stability0.62088709
95MP0001845_abnormal_inflammatory_respons0.61609640
96MP0002177_abnormal_outer_ear0.59471314
97MP0005623_abnormal_meninges_morphology0.58329228
98MP0001697_abnormal_embryo_size0.57568762
99MP0004142_abnormal_muscle_tone0.56708211
100MP0000747_muscle_weakness0.56568576

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal dysplasia (HP:0100255)5.44416604
2Abnormality of the phalanges of the 2nd finger (HP:0009541)5.08370320
3Short middle phalanx of the 5th finger (HP:0004220)5.06732601
4Spondylolisthesis (HP:0003302)4.53346581
5Absent frontal sinuses (HP:0002688)4.38046406
6Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.28238012
7Abnormality of the parietal bone (HP:0002696)4.13568588
8Abnormality of cells of the erythroid lineage (HP:0012130)4.06291038
9Spinal cord lesions (HP:0100561)4.05730904
10Syringomyelia (HP:0003396)4.05730904
11Potter facies (HP:0002009)3.98369845
12Facial shape deformation (HP:0011334)3.98369845
13Reticulocytopenia (HP:0001896)3.97031765
14Abnormality of the frontal sinuses (HP:0002687)3.89461952
15Neonatal respiratory distress (HP:0002643)3.87208038
16Autoimmune hemolytic anemia (HP:0001890)3.86572185
17Hypochromic microcytic anemia (HP:0004840)3.73589819
18Abnormal number of erythroid precursors (HP:0012131)3.67238142
19IgM deficiency (HP:0002850)3.66845102
20IgA deficiency (HP:0002720)3.55536730
21Stomatitis (HP:0010280)3.54842373
22Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.40841192
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.38685911
24Abnormality of macular pigmentation (HP:0008002)3.38559783
25Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.34734734
26Abnormality of the 2nd finger (HP:0004100)3.32131552
27Ileus (HP:0002595)3.31562014
28Supernumerary ribs (HP:0005815)3.31303165
29Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.27938574
30Supernumerary bones of the axial skeleton (HP:0009144)3.25291733
31Medulloblastoma (HP:0002885)3.20271461
32Thyroiditis (HP:0100646)3.16689240
33Enlarged epiphyses (HP:0010580)3.06397656
34Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.04135227
35Abnormality of the phalanges of the 5th finger (HP:0004213)3.02195865
36Thickened calvaria (HP:0002684)3.01343875
37Abnormality of the costochondral junction (HP:0000919)2.99013471
38Neoplasm of the tracheobronchial system (HP:0100552)2.90905223
39Pancreatic cysts (HP:0001737)2.89402543
40Abnormality of the pubic bones (HP:0003172)2.87832053
41Hypoplastic iliac wings (HP:0002866)2.85571533
42Abnormality of the prostate (HP:0008775)2.81813555
43Rhabdomyosarcoma (HP:0002859)2.74638037
44Tubulointerstitial fibrosis (HP:0005576)2.68884021
45Thin bony cortex (HP:0002753)2.66636437
46Papillary thyroid carcinoma (HP:0002895)2.64204850
47Symptomatic seizures (HP:0011145)2.62439394
48Colon cancer (HP:0003003)2.60108488
49Enlarged kidneys (HP:0000105)2.57433114
50Nephroblastoma (Wilms tumor) (HP:0002667)2.54363081
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.48471656
52Embryonal renal neoplasm (HP:0011794)2.43064177
53Increased number of teeth (HP:0011069)2.38389848
54Short 5th finger (HP:0009237)2.37527834
55Abnormality of the renal cortex (HP:0011035)2.37111181
56Esophageal varix (HP:0002040)2.36547129
57Generalized hypopigmentation of hair (HP:0011358)2.33180190
58Abnormality of dental color (HP:0011073)2.30887867
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29253829
60Abnormality of alanine metabolism (HP:0010916)2.29253829
61Hyperalaninemia (HP:0003348)2.29253829
62Hyperparathyroidism (HP:0000843)2.24032086
63Neonatal death (HP:0003811)2.23735091
64Macroorchidism (HP:0000053)2.20649221
65Flat occiput (HP:0005469)2.20063972
66Abnormality of T cell physiology (HP:0011840)2.19929415
67Delayed epiphyseal ossification (HP:0002663)2.18013658
68Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.17727102
69Abnormality of primary teeth (HP:0006481)2.15425823
70Abnormality of T cells (HP:0002843)2.11603265
71Submucous cleft hard palate (HP:0000176)2.06894941
72Portal hypertension (HP:0001409)2.06032215
73Joint swelling (HP:0001386)2.05942192
74Deep palmar crease (HP:0006191)2.02237188
75Abnormality of small intestinal villus morphology (HP:0011472)1.99689418
76Villous atrophy (HP:0011473)1.99689418
77Abnormality of male internal genitalia (HP:0000022)1.96754973
78Multiple enchondromatosis (HP:0005701)1.95240192
79Palpebral edema (HP:0100540)1.94838536
80Pulmonary infiltrates (HP:0002113)1.92594781
81Abnormality of the humerus (HP:0003063)1.92493482
82Thyroid carcinoma (HP:0002890)1.91980232
83Narrow palate (HP:0000189)1.91917862
84Abnormality of the upper arm (HP:0001454)1.91084536
85Craniofacial hyperostosis (HP:0004493)1.87175365
86T lymphocytopenia (HP:0005403)1.87004345
87Short femoral neck (HP:0100864)1.86036146
88Rhinitis (HP:0012384)1.85202365
89Macrocytic anemia (HP:0001972)1.85184947
90Hypochromic anemia (HP:0001931)1.84902467
91Abnormality of the hepatic vasculature (HP:0006707)1.84753325
92Interstitial pulmonary disease (HP:0006530)1.84537927
93Abnormality of T cell number (HP:0011839)1.81926260
94Ulnar deviation of the wrist (HP:0003049)1.79229356
95Ureteral stenosis (HP:0000071)1.77963653
96Premature loss of primary teeth (HP:0006323)1.77420600
97Abnormality of hair growth rate (HP:0011363)1.71441496
98Slow-growing hair (HP:0002217)1.71441496
99Chronic diarrhea (HP:0002028)1.70974908
100Upper limb muscle weakness (HP:0003484)1.69467006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.83173158
2NME23.63314355
3TLK13.31040444
4IRAK12.91326218
5STK162.79901571
6IRAK22.66572113
7MST42.65103884
8EPHB22.26287208
9STK242.22140890
10RPS6KA42.21683936
11CAMKK22.15640875
12IRAK41.91766694
13MAP3K91.89614454
14BMPR1B1.85750238
15TAF11.74722928
16ARAF1.73379157
17TYRO31.71320488
18SCYL21.67355078
19MAP3K131.67054973
20ITK1.64710043
21NEK11.61816122
22VRK21.59233933
23MKNK21.57855884
24TGFBR11.54369521
25IKBKE1.54060824
26SRPK11.43382746
27PASK1.28626178
28DYRK31.27601735
29CAMK1D1.22823438
30HIPK21.22213356
31TEC1.21421827
32BTK1.21151809
33MKNK11.20188744
34BRD41.11070512
35CAMKK11.09611984
36AKT31.08997278
37TNIK1.07455234
38BRAF1.01155151
39NUAK10.99623331
40RPS6KA50.99463186
41VRK10.97224306
42PHKG20.96069920
43PHKG10.96069920
44WNK10.95058162
45MAP4K10.90953349
46PRKCE0.89019339
47BRSK20.88253713
48NLK0.88200273
49BCR0.87233878
50LCK0.80990668
51EIF2AK30.80234166
52CDK90.79759768
53DYRK20.74106370
54CSNK1A1L0.72413913
55MOS0.67969107
56CDK80.67209250
57CAMK1G0.64451193
58SGK20.63948074
59PLK30.63767287
60CAMK40.59539192
61STK30.55410456
62ACVR1B0.49589900
63TRIM280.48985693
64TBK10.48292146
65TSSK60.48247111
66PRKCQ0.47299787
67CCNB10.47065750
68BUB10.46392155
69MAPK70.45757323
70WNK30.45749140
71IKBKB0.45106223
72BCKDK0.44447764
73CSNK1G20.43606693
74NEK20.43187126
75OBSCN0.43155034
76CHUK0.42156957
77MARK30.40970852
78CDK70.40954928
79SGK4940.40085884
80SGK2230.40085884
81JAK30.39884477
82MAP3K100.38650201
83CASK0.38333834
84HCK0.37585793
85TAOK30.36168949
86SYK0.33626361
87SGK30.29692741
88CAMK2G0.29632779
89CSNK1G30.29305335
90TAOK20.29013108
91CDK30.25585823
92FGFR10.24649294
93CSNK2A10.23494145
94CAMK10.23429908
95SIK30.22588441
96CHEK20.22161724
97TYK20.22068288
98JAK20.21256867
99PBK0.20658261
100MAP3K120.20183510

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.06959683
2Protein export_Homo sapiens_hsa030603.33307866
3T cell receptor signaling pathway_Homo sapiens_hsa046603.12488416
4Autoimmune thyroid disease_Homo sapiens_hsa053203.00119949
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.57498941
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.55218031
7Proteasome_Homo sapiens_hsa030502.34633941
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33311489
9RNA polymerase_Homo sapiens_hsa030202.28431005
10Asthma_Homo sapiens_hsa053102.26405034
11Spliceosome_Homo sapiens_hsa030402.23401380
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15847443
13Primary immunodeficiency_Homo sapiens_hsa053402.13260356
14Allograft rejection_Homo sapiens_hsa053301.93901898
15Mismatch repair_Homo sapiens_hsa034301.90087094
16Measles_Homo sapiens_hsa051621.84340280
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.66485956
18RNA degradation_Homo sapiens_hsa030181.56433808
19Basal transcription factors_Homo sapiens_hsa030221.55878214
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.50518114
21Circadian rhythm_Homo sapiens_hsa047101.47564062
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39310308
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37947159
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31496848
25RNA transport_Homo sapiens_hsa030131.28592712
26Hematopoietic cell lineage_Homo sapiens_hsa046401.27066008
27Sulfur metabolism_Homo sapiens_hsa009201.25191389
28DNA replication_Homo sapiens_hsa030301.24644754
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24429721
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22747944
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.18854287
32mRNA surveillance pathway_Homo sapiens_hsa030151.12176080
33Oxidative phosphorylation_Homo sapiens_hsa001901.11866592
34Rheumatoid arthritis_Homo sapiens_hsa053231.11317018
35Nucleotide excision repair_Homo sapiens_hsa034201.09212592
36Viral carcinogenesis_Homo sapiens_hsa052031.08037346
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.08019945
38Homologous recombination_Homo sapiens_hsa034401.06070382
39Systemic lupus erythematosus_Homo sapiens_hsa053221.04730898
40Dorso-ventral axis formation_Homo sapiens_hsa043201.02778269
41Epstein-Barr virus infection_Homo sapiens_hsa051691.01612627
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01522316
43TGF-beta signaling pathway_Homo sapiens_hsa043501.00384733
44Starch and sucrose metabolism_Homo sapiens_hsa005000.98693850
45Alcoholism_Homo sapiens_hsa050340.95584063
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.95053505
47Fanconi anemia pathway_Homo sapiens_hsa034600.94800745
48Long-term potentiation_Homo sapiens_hsa047200.82048213
49Pyrimidine metabolism_Homo sapiens_hsa002400.81563996
50Retinol metabolism_Homo sapiens_hsa008300.80886727
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76003190
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.74527603
53Huntingtons disease_Homo sapiens_hsa050160.73722361
54MicroRNAs in cancer_Homo sapiens_hsa052060.72132593
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69700207
56Amphetamine addiction_Homo sapiens_hsa050310.68076203
57Graft-versus-host disease_Homo sapiens_hsa053320.66211951
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63979467
59Wnt signaling pathway_Homo sapiens_hsa043100.62979929
60Parkinsons disease_Homo sapiens_hsa050120.62095005
61MAPK signaling pathway_Homo sapiens_hsa040100.58995798
62Colorectal cancer_Homo sapiens_hsa052100.58701691
63HTLV-I infection_Homo sapiens_hsa051660.56621899
64Purine metabolism_Homo sapiens_hsa002300.56156990
65One carbon pool by folate_Homo sapiens_hsa006700.55453228
66Cocaine addiction_Homo sapiens_hsa050300.54794947
67Renal cell carcinoma_Homo sapiens_hsa052110.54561220
68Tight junction_Homo sapiens_hsa045300.53040356
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50448879
70Hepatitis B_Homo sapiens_hsa051610.49621468
71Pancreatic cancer_Homo sapiens_hsa052120.47858960
72Vitamin B6 metabolism_Homo sapiens_hsa007500.46070019
73Cell cycle_Homo sapiens_hsa041100.45950911
74Type I diabetes mellitus_Homo sapiens_hsa049400.45014125
75VEGF signaling pathway_Homo sapiens_hsa043700.43576757
76Base excision repair_Homo sapiens_hsa034100.42223314
77Thyroid cancer_Homo sapiens_hsa052160.41391630
78Non-small cell lung cancer_Homo sapiens_hsa052230.39962605
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.36399912
80Adherens junction_Homo sapiens_hsa045200.35929723
81Dopaminergic synapse_Homo sapiens_hsa047280.33378060
82TNF signaling pathway_Homo sapiens_hsa046680.33367537
83Chemical carcinogenesis_Homo sapiens_hsa052040.32012744
84Viral myocarditis_Homo sapiens_hsa054160.31972582
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31674609
86Morphine addiction_Homo sapiens_hsa050320.31357019
87Regulation of autophagy_Homo sapiens_hsa041400.29934089
88Ras signaling pathway_Homo sapiens_hsa040140.29859127
89Nicotine addiction_Homo sapiens_hsa050330.29846866
90p53 signaling pathway_Homo sapiens_hsa041150.29326734
91ErbB signaling pathway_Homo sapiens_hsa040120.28350781
92Cardiac muscle contraction_Homo sapiens_hsa042600.27523995
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27386633
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.27027687
95Herpes simplex infection_Homo sapiens_hsa051680.23673719
96B cell receptor signaling pathway_Homo sapiens_hsa046620.21970850
97Phototransduction_Homo sapiens_hsa047440.21877474
98Oocyte meiosis_Homo sapiens_hsa041140.21189281
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20953126
100Vibrio cholerae infection_Homo sapiens_hsa051100.20562351

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