NPM1P45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)8.48277877
2regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)7.32626201
3regulation of isotype switching to IgG isotypes (GO:0048302)6.45536524
4positive regulation of interleukin-17 production (GO:0032740)6.33670176
5regulation of immunoglobulin secretion (GO:0051023)6.11983952
6DNA deamination (GO:0045006)5.65558282
7regulation of regulatory T cell differentiation (GO:0045589)5.22578145
8positive regulation of isotype switching (GO:0045830)5.16852693
9positive regulation of DNA recombination (GO:0045911)4.66858286
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.66845183
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.54205054
12cellular response to interleukin-15 (GO:0071350)4.38576849
13proteasome assembly (GO:0043248)4.21033719
14positive regulation of immunoglobulin production (GO:0002639)4.03663927
15transcription elongation from RNA polymerase I promoter (GO:0006362)3.97611496
16positive regulation of activated T cell proliferation (GO:0042104)3.97517217
17interferon-gamma production (GO:0032609)3.91761646
18negative regulation of B cell apoptotic process (GO:0002903)3.87043015
19termination of RNA polymerase I transcription (GO:0006363)3.86746767
20positive regulation of T-helper 1 type immune response (GO:0002827)3.81682834
21regulation of podosome assembly (GO:0071801)3.81174133
22cytidine deamination (GO:0009972)3.80713861
23cytidine metabolic process (GO:0046087)3.80713861
24cytidine catabolic process (GO:0006216)3.80713861
25maturation of 5.8S rRNA (GO:0000460)3.80440790
26pseudouridine synthesis (GO:0001522)3.75939827
27regulation of chronic inflammatory response (GO:0002676)3.73573634
28negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.66204888
29positive regulation of immunoglobulin mediated immune response (GO:0002891)3.65895052
30positive regulation of B cell mediated immunity (GO:0002714)3.65895052
31CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.64924862
32T-helper cell differentiation (GO:0042093)3.64924862
33L-fucose catabolic process (GO:0042355)3.54063744
34fucose catabolic process (GO:0019317)3.54063744
35L-fucose metabolic process (GO:0042354)3.54063744
36positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.50889655
37otic vesicle formation (GO:0030916)3.50650387
38positive regulation of defense response to virus by host (GO:0002230)3.46654952
39T cell differentiation involved in immune response (GO:0002292)3.44546540
40alpha-beta T cell differentiation involved in immune response (GO:0002293)3.44546540
41alpha-beta T cell activation involved in immune response (GO:0002287)3.44546540
42response to interleukin-15 (GO:0070672)3.42631545
43rRNA methylation (GO:0031167)3.41939909
44regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.40289714
45regulation of memory T cell differentiation (GO:0043380)3.38656734
46rRNA modification (GO:0000154)3.37390114
47chaperone-mediated protein transport (GO:0072321)3.33568174
48regulation of interleukin-17 production (GO:0032660)3.29465522
49rRNA processing (GO:0006364)3.28393864
50water-soluble vitamin biosynthetic process (GO:0042364)3.27074786
51positive regulation of JAK-STAT cascade (GO:0046427)3.25498654
52positive regulation of cell fate commitment (GO:0010455)3.24449656
53pyrimidine ribonucleoside catabolic process (GO:0046133)3.23494596
54peptidyl-histidine modification (GO:0018202)3.17146013
55rRNA metabolic process (GO:0016072)3.16007705
56transcription initiation from RNA polymerase I promoter (GO:0006361)3.12893231
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12463303
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12463303
59negative regulation of T-helper cell differentiation (GO:0045623)3.10803106
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10803106
61regulation of isotype switching (GO:0045191)3.05062940
62ribosome assembly (GO:0042255)3.04634782
63regulation of cellular amino acid metabolic process (GO:0006521)3.03661908
64negative regulation of telomere maintenance (GO:0032205)3.03044969
65DNA double-strand break processing (GO:0000729)3.01693499
66transcription from RNA polymerase I promoter (GO:0006360)3.00500904
67energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95318409
68ATP synthesis coupled proton transport (GO:0015986)2.95318409
69platelet dense granule organization (GO:0060155)2.94481602
70respiratory chain complex IV assembly (GO:0008535)2.94052857
71pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.93718292
72UMP metabolic process (GO:0046049)2.93718292
73pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.93718292
74UMP biosynthetic process (GO:0006222)2.93718292
75regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.93415846
76regulation of immunoglobulin production (GO:0002637)2.91663887
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91650946
78regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.87597743
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85650343
80transcription from mitochondrial promoter (GO:0006390)2.81609849
81regulation of activated T cell proliferation (GO:0046006)2.81513797
82behavioral response to nicotine (GO:0035095)2.79895534
83regulation of T-helper 1 type immune response (GO:0002825)2.79003563
84regulation of T cell mediated cytotoxicity (GO:0001914)2.78974273
85mitochondrial RNA metabolic process (GO:0000959)2.78572247
86alpha-beta T cell differentiation (GO:0046632)2.75101506
87mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.74207924
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73335580
89pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.73040432
90ribosome biogenesis (GO:0042254)2.72922214
91CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.72277688
92pyrimidine ribonucleoside metabolic process (GO:0046131)2.72040477
93positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.70805348
94signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69622451
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69622451
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69622451
97telomere maintenance via telomerase (GO:0007004)2.66926119
98preassembly of GPI anchor in ER membrane (GO:0016254)2.66209192
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.66181423
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.66181423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.52811440
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98195262
3NOTCH1_21737748_ChIP-Seq_TLL_Human3.64654839
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.17323934
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.14728935
6VDR_22108803_ChIP-Seq_LS180_Human3.07238317
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.81038627
8VDR_23849224_ChIP-Seq_CD4+_Human2.69636988
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57021026
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.53064752
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52382082
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46706952
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46177735
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40802618
15ELK1_19687146_ChIP-ChIP_HELA_Human2.33293942
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28675865
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28501801
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.27270287
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.19463414
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.10808964
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04133998
22ZNF274_21170338_ChIP-Seq_K562_Hela1.97949705
23FOXP3_21729870_ChIP-Seq_TREG_Human1.97866637
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.96637053
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91981305
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90080706
27TAF15_26573619_Chip-Seq_HEK293_Human1.89956912
28EWS_26573619_Chip-Seq_HEK293_Human1.87374174
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83004616
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.77103756
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73109603
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.63921196
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.63357839
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63236040
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61527667
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.59260358
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57500178
38MYC_18940864_ChIP-ChIP_HL60_Human1.52381238
39FUS_26573619_Chip-Seq_HEK293_Human1.50959062
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49540226
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49426804
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49297714
43TP53_22573176_ChIP-Seq_HFKS_Human1.47622919
44NANOG_19829295_ChIP-Seq_ESCs_Human1.46829408
45SOX2_19829295_ChIP-Seq_ESCs_Human1.46829408
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45420171
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43238838
48ER_23166858_ChIP-Seq_MCF-7_Human1.39698051
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39694821
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36569242
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36467191
52DCP1A_22483619_ChIP-Seq_HELA_Human1.33758890
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32802686
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30378289
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.28756707
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26732921
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.25249375
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.24904091
59P300_19829295_ChIP-Seq_ESCs_Human1.23934196
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20945497
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20511810
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19554823
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.18931826
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15258394
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14597928
66GATA3_26560356_Chip-Seq_TH2_Human1.13518173
67TTF2_22483619_ChIP-Seq_HELA_Human1.13281382
68GABP_19822575_ChIP-Seq_HepG2_Human1.11253843
69OCT4_18555785_Chip-Seq_ESCs_Mouse1.10943420
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10249485
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.09579562
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08873335
73P300_18555785_Chip-Seq_ESCs_Mouse1.05527289
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.04619957
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02399374
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02188938
77AR_21572438_ChIP-Seq_LNCaP_Human1.01678682
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01382709
79AR_20517297_ChIP-Seq_VCAP_Human1.01141095
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.00696889
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00696889
82PHF8_20622853_ChIP-Seq_HELA_Human0.98247517
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97935903
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96263856
85STAT3_18555785_Chip-Seq_ESCs_Mouse0.95963283
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95319582
87SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94972970
88SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94118670
89NCOR_22424771_ChIP-Seq_293T_Human0.94034404
90MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93547487
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93276191
92GATA1_22025678_ChIP-Seq_K562_Human0.92651817
93RBPJ_21746931_ChIP-Seq_IB4_Human0.92396835
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92381242
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92295017
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92295017
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92036371
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91756594
99KLF4_18555785_Chip-Seq_ESCs_Mouse0.91527214
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.91525442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.94345640
2MP0000566_synostosis3.65453658
3MP0005084_abnormal_gallbladder_morpholo2.98932282
4MP0005670_abnormal_white_adipose2.90419263
5MP0001853_heart_inflammation2.71227539
6MP0003136_yellow_coat_color2.49199007
7MP0003300_gastrointestinal_ulcer2.43828766
8MP0000465_gastrointestinal_hemorrhage2.38296951
9MP0006292_abnormal_olfactory_placode2.27778301
10MP0008877_abnormal_DNA_methylation2.18417123
11MP0001873_stomach_inflammation2.17325811
12MP0002138_abnormal_hepatobiliary_system2.16276503
13MP0003878_abnormal_ear_physiology2.15576225
14MP0005377_hearing/vestibular/ear_phenot2.15576225
15MP0005387_immune_system_phenotype2.03267678
16MP0001790_abnormal_immune_system2.03267678
17MP0008872_abnormal_physiological_respon1.91022659
18MP0003786_premature_aging1.88712899
19MP0005645_abnormal_hypothalamus_physiol1.87326751
20MP0004381_abnormal_hair_follicle1.82823396
21MP0005671_abnormal_response_to1.79746690
22MP0003567_abnormal_fetal_cardiomyocyte1.79292539
23MP0009785_altered_susceptibility_to1.78780444
24MP0002166_altered_tumor_susceptibility1.77197773
25MP0000685_abnormal_immune_system1.75320661
26MP0002148_abnormal_hypersensitivity_rea1.68093352
27MP0000604_amyloidosis1.65153670
28MP0001502_abnormal_circadian_rhythm1.64342922
29MP0001800_abnormal_humoral_immune1.63801224
30MP0001661_extended_life_span1.63327225
31MP0006072_abnormal_retinal_apoptosis1.60112998
32MP0002102_abnormal_ear_morphology1.58606760
33MP0002006_tumorigenesis1.56059827
34MP0009333_abnormal_splenocyte_physiolog1.53422357
35MP0003718_maternal_effect1.46088809
36MP0000372_irregular_coat_pigmentation1.46084584
37MP0008058_abnormal_DNA_repair1.45455764
38MP0001986_abnormal_taste_sensitivity1.42909674
39MP0005085_abnormal_gallbladder_physiolo1.40034225
40MP0000427_abnormal_hair_cycle1.40024082
41MP0003646_muscle_fatigue1.37296494
42MP0005310_abnormal_salivary_gland1.36580863
43MP0004957_abnormal_blastocyst_morpholog1.33058235
44MP0003950_abnormal_plasma_membrane1.30525884
45MP0003195_calcinosis1.29291658
46MP0004142_abnormal_muscle_tone1.28876432
47MP0000569_abnormal_digit_pigmentation1.28666836
48MP0008875_abnormal_xenobiotic_pharmacok1.23937933
49MP0001501_abnormal_sleep_pattern1.22272565
50MP0002938_white_spotting1.21662610
51MP0005551_abnormal_eye_electrophysiolog1.20969591
52MP0005000_abnormal_immune_tolerance1.20476899
53MP0002277_abnormal_respiratory_mucosa1.18519853
54MP0001958_emphysema1.16937000
55MP0001529_abnormal_vocalization1.15160889
56MP0003763_abnormal_thymus_physiology1.14592687
57MP0001188_hyperpigmentation1.11979124
58MP0001485_abnormal_pinna_reflex1.10435623
59MP0002282_abnormal_trachea_morphology1.05960569
60MP0001984_abnormal_olfaction1.03446262
61MP0005379_endocrine/exocrine_gland_phen1.02730860
62MP0002723_abnormal_immune_serum1.01954908
63MP0006082_CNS_inflammation1.01714811
64MP0003186_abnormal_redox_activity0.93694985
65MP0003866_abnormal_defecation0.93342605
66MP0005025_abnormal_response_to0.93334549
67MP0010329_abnormal_lipoprotein_level0.92885642
68MP0001968_abnormal_touch/_nociception0.92815364
69MP0002736_abnormal_nociception_after0.92058616
70MP0004742_abnormal_vestibular_system0.89205265
71MP0003936_abnormal_reproductive_system0.89180767
72MP0002272_abnormal_nervous_system0.89027137
73MP0002420_abnormal_adaptive_immunity0.88771088
74MP0000537_abnormal_urethra_morphology0.88747627
75MP0002693_abnormal_pancreas_physiology0.88581912
76MP0004885_abnormal_endolymph0.88001757
77MP0006035_abnormal_mitochondrial_morpho0.87376781
78MP0002405_respiratory_system_inflammati0.86891616
79MP0001819_abnormal_immune_cell0.84866864
80MP0000371_diluted_coat_color0.84056320
81MP0004145_abnormal_muscle_electrophysio0.83730028
82MP0005389_reproductive_system_phenotype0.83557233
83MP0004134_abnormal_chest_morphology0.79665996
84MP0005083_abnormal_biliary_tract0.79552746
85MP0000631_abnormal_neuroendocrine_gland0.78849829
86MP0003787_abnormal_imprinting0.78800438
87MP0001845_abnormal_inflammatory_respons0.78171468
88MP0010155_abnormal_intestine_physiology0.77617968
89MP0001919_abnormal_reproductive_system0.77381854
90MP0005636_abnormal_mineral_homeostasis0.76631856
91MP0005332_abnormal_amino_acid0.74766778
92MP0000689_abnormal_spleen_morphology0.74282207
93MP0002452_abnormal_antigen_presenting0.73951281
94MP0005386_behavior/neurological_phenoty0.71685156
95MP0004924_abnormal_behavior0.71685156
96MP0002398_abnormal_bone_marrow0.71477338
97MP0003252_abnormal_bile_duct0.70428638
98MP0005075_abnormal_melanosome_morpholog0.68300075
99MP0006036_abnormal_mitochondrial_physio0.65947957
100MP0001881_abnormal_mammary_gland0.65291917

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the pons (HP:0007361)4.62612035
2Stomatitis (HP:0010280)4.12115028
3Abnormality of the labia minora (HP:0012880)3.79594483
4Oral leukoplakia (HP:0002745)3.63961035
5Hypoplasia of the pons (HP:0012110)3.51326715
6Increased hepatocellular lipid droplets (HP:0006565)3.36572534
7Large for gestational age (HP:0001520)3.23394579
8Conical tooth (HP:0000698)3.14548668
9IgG deficiency (HP:0004315)3.14481726
10Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.05435092
11Lipid accumulation in hepatocytes (HP:0006561)3.01692827
12Megalencephaly (HP:0001355)2.94982765
133-Methylglutaconic aciduria (HP:0003535)2.93424679
14Pancreatic cysts (HP:0001737)2.90881463
15Severe combined immunodeficiency (HP:0004430)2.87894482
16Aplastic anemia (HP:0001915)2.81738501
17Renal Fanconi syndrome (HP:0001994)2.76122930
18Supernumerary bones of the axial skeleton (HP:0009144)2.75196222
19Acute necrotizing encephalopathy (HP:0006965)2.72169146
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71424866
21Congenital, generalized hypertrichosis (HP:0004540)2.70131650
22Lip pit (HP:0100267)2.70082276
23Abnormality of midbrain morphology (HP:0002418)2.66797533
24Molar tooth sign on MRI (HP:0002419)2.66797533
25Thyroiditis (HP:0100646)2.61312354
26Increased CSF lactate (HP:0002490)2.60813225
27Abnormality of the middle phalanges of the toes (HP:0010183)2.59896613
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59745830
29Short tibia (HP:0005736)2.46233680
30Optic neuritis (HP:0100653)2.45368786
31Retrobulbar optic neuritis (HP:0100654)2.45368786
32Type II lissencephaly (HP:0007260)2.44733879
33Mitochondrial inheritance (HP:0001427)2.38378976
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.38282741
35Aplasia/Hypoplasia of the ulna (HP:0006495)2.37742509
36Hypoplasia of the ulna (HP:0003022)2.33786736
37Abnormality of the phalanges of the 2nd finger (HP:0009541)2.33572840
38Increased serum lactate (HP:0002151)2.32035219
39Abnormal pupillary function (HP:0007686)2.30834695
40Acute encephalopathy (HP:0006846)2.30583899
41Progressive macrocephaly (HP:0004481)2.30149838
42Abnormality of the parietal bone (HP:0002696)2.29181334
43Abnormality of methionine metabolism (HP:0010901)2.27027772
44Duplicated collecting system (HP:0000081)2.25517377
45Cupped ear (HP:0000378)2.25209179
46Aplasia/hypoplasia of the uterus (HP:0008684)2.22788174
472-3 toe syndactyly (HP:0004691)2.21969375
48Elevated erythrocyte sedimentation rate (HP:0003565)2.20829838
49Supernumerary ribs (HP:0005815)2.19377116
50Recurrent cutaneous fungal infections (HP:0011370)2.18433586
51Chronic mucocutaneous candidiasis (HP:0002728)2.18433586
52Abnormality of the diencephalon (HP:0010662)2.18405468
53Esophageal atresia (HP:0002032)2.17228355
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16142526
55T lymphocytopenia (HP:0005403)2.15986834
56Combined immunodeficiency (HP:0005387)2.14658578
57Abnormal mitochondria in muscle tissue (HP:0008316)2.14293531
58Hypoplasia of the radius (HP:0002984)2.11999400
59Facial cleft (HP:0002006)2.11774781
60Renal cortical cysts (HP:0000803)2.10422501
61True hermaphroditism (HP:0010459)2.09865654
62Milia (HP:0001056)2.08382744
63Nasolacrimal duct obstruction (HP:0000579)2.07456470
64Abnormality of the renal collecting system (HP:0004742)2.07411371
65Vertebral fusion (HP:0002948)2.05852638
66Gastrointestinal atresia (HP:0002589)2.05696842
67Pancreatic fibrosis (HP:0100732)2.05244261
68Aplasia involving bones of the upper limbs (HP:0009823)2.03932281
69Aplasia of the phalanges of the hand (HP:0009802)2.03932281
70Aplasia involving bones of the extremities (HP:0009825)2.03932281
71Intestinal atresia (HP:0011100)2.02535128
72Orchitis (HP:0100796)2.02105200
73Short phalanx of the thumb (HP:0009660)2.02083348
74Bilateral microphthalmos (HP:0007633)2.01200967
75Sparse lateral eyebrow (HP:0005338)2.00517693
76Fused cervical vertebrae (HP:0002949)1.98277544
77Posterior subcapsular cataract (HP:0007787)1.97527914
78Fibular hypoplasia (HP:0003038)1.96633453
79Forearm undergrowth (HP:0009821)1.96099925
80Aplasia/Hypoplasia of the fibula (HP:0006492)1.95622572
81Pendular nystagmus (HP:0012043)1.95441862
82Exertional dyspnea (HP:0002875)1.94684677
83Partial duplication of thumb phalanx (HP:0009944)1.94269515
84Absent radius (HP:0003974)1.94070223
85Congenital stationary night blindness (HP:0007642)1.93488138
86Brittle hair (HP:0002299)1.89322088
87Glossoptosis (HP:0000162)1.88271398
88Poor head control (HP:0002421)1.85694087
89Abnormality of the lacrimal duct (HP:0011481)1.85476936
90Abnormality of T cells (HP:0002843)1.84829567
91Short hallux (HP:0010109)1.84401603
92Absent forearm bone (HP:0003953)1.83904851
93Aplasia involving forearm bones (HP:0009822)1.83904851
94Multiple enchondromatosis (HP:0005701)1.83806217
95Median cleft lip (HP:0000161)1.82195851
96Short thumb (HP:0009778)1.80871739
97Abnormality of homocysteine metabolism (HP:0010919)1.78450317
98Homocystinuria (HP:0002156)1.78450317
99Abnormality of T cell number (HP:0011839)1.78426613
100Azoospermia (HP:0000027)1.77873657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.93975161
2MST44.12684063
3NUAK13.51925163
4EIF2AK13.28408813
5TXK2.99994258
6SRPK12.68519212
7NME12.58390785
8EIF2AK32.45384800
9PINK12.19817841
10FGFR22.18991938
11TLK12.17477479
12MKNK22.13712525
13VRK22.04522587
14TESK11.96385017
15ADRBK21.86800398
16FRK1.82109929
17ZAK1.77888884
18ALK1.76477431
19FES1.72956788
20PBK1.66658549
21EIF2AK21.60088950
22BUB11.54882902
23GRK11.49135623
24INSRR1.48203110
25PLK31.44824147
26MAP2K61.42993951
27TRIM281.38065388
28IKBKE1.34142566
29SIK31.30314470
30MAP3K141.29869576
31WNK41.29716465
32FGFR31.26643615
33MKNK11.20826876
34FGFR11.19409552
35VRK11.11842536
36CASK1.07502080
37TEC1.06951138
38AKT30.98638412
39TAOK30.97996717
40NLK0.97218096
41NEK10.96249821
42PASK0.90603331
43PIK3CG0.88175395
44JAK30.87843848
45PDK20.86853331
46IKBKB0.78912338
47TAF10.73636265
48OXSR10.72586443
49DAPK20.72174214
50DAPK10.72136109
51MAPKAPK30.69541322
52KIT0.68226321
53KDR0.64428024
54CSK0.64411082
55TIE10.64335132
56STK40.64025546
57BMPR1B0.63856310
58PAK30.63588059
59ITK0.62734332
60TNIK0.60478720
61STK390.58193832
62TAOK10.55266253
63WNK30.55119100
64CSNK1G10.54567891
65PAK40.52827159
66LATS10.52223258
67PHKG20.52172402
68PHKG10.52172402
69STK30.51593691
70DYRK20.50451631
71TGFBR10.48749118
72MAP4K20.48663668
73CSNK1A1L0.47909625
74JAK10.46930936
75PRKCQ0.45672344
76STK380.45622562
77MARK30.43911046
78CSNK1G30.43908293
79CSNK1E0.42248607
80STK38L0.39092794
81LCK0.38631250
82ACVR1B0.37641243
83MAPKAPK20.36885180
84TNK20.36443445
85PRKCE0.35196835
86ADRBK10.34958578
87ATR0.34528164
88IGF1R0.33623116
89CCNB10.33422813
90WEE10.33168562
91PLK10.32943430
92DYRK30.32811096
93PRKCG0.31589505
94TYK20.30138605
95PLK20.27333532
96PNCK0.27092143
97SGK20.26663255
98RPS6KA50.24469150
99CSNK2A10.23333440
100CSNK2A20.20194179

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.39827366
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.06708075
3Allograft rejection_Homo sapiens_hsa053303.13084182
4Autoimmune thyroid disease_Homo sapiens_hsa053202.96037127
5Asthma_Homo sapiens_hsa053102.75118813
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.68900605
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.43811412
8Basal transcription factors_Homo sapiens_hsa030222.22994535
9Primary immunodeficiency_Homo sapiens_hsa053402.03378290
10Oxidative phosphorylation_Homo sapiens_hsa001902.01121248
11RNA polymerase_Homo sapiens_hsa030202.00362085
12Protein export_Homo sapiens_hsa030601.99563986
13Type I diabetes mellitus_Homo sapiens_hsa049401.98698900
14Sulfur metabolism_Homo sapiens_hsa009201.97919458
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97706526
16One carbon pool by folate_Homo sapiens_hsa006701.97315151
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87220127
18Homologous recombination_Homo sapiens_hsa034401.79567446
19Graft-versus-host disease_Homo sapiens_hsa053321.76752436
20RNA transport_Homo sapiens_hsa030131.75499351
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.71220475
22Vitamin B6 metabolism_Homo sapiens_hsa007501.68193787
23RNA degradation_Homo sapiens_hsa030181.65375411
24Spliceosome_Homo sapiens_hsa030401.53169076
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50706640
26Propanoate metabolism_Homo sapiens_hsa006401.50169366
27Parkinsons disease_Homo sapiens_hsa050121.42539610
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.36180102
29Steroid biosynthesis_Homo sapiens_hsa001001.36016650
30Peroxisome_Homo sapiens_hsa041461.34215781
31Non-homologous end-joining_Homo sapiens_hsa034501.33740228
32Ribosome_Homo sapiens_hsa030101.30632211
33Pyrimidine metabolism_Homo sapiens_hsa002401.29877321
34Nitrogen metabolism_Homo sapiens_hsa009101.27913086
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27854896
36Hematopoietic cell lineage_Homo sapiens_hsa046401.21737577
37Butanoate metabolism_Homo sapiens_hsa006501.20710619
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17637073
39Linoleic acid metabolism_Homo sapiens_hsa005911.14538944
40Measles_Homo sapiens_hsa051621.13401542
41T cell receptor signaling pathway_Homo sapiens_hsa046601.07901346
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.02568508
43Purine metabolism_Homo sapiens_hsa002301.02311233
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.02009583
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97347630
46Circadian rhythm_Homo sapiens_hsa047100.93405528
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91192098
48Nucleotide excision repair_Homo sapiens_hsa034200.90757850
49Fat digestion and absorption_Homo sapiens_hsa049750.88344393
50Caffeine metabolism_Homo sapiens_hsa002320.88336655
51Tryptophan metabolism_Homo sapiens_hsa003800.85641055
52Huntingtons disease_Homo sapiens_hsa050160.84030049
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82770565
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81186690
55Mismatch repair_Homo sapiens_hsa034300.79402218
56Collecting duct acid secretion_Homo sapiens_hsa049660.78874087
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78200299
58Fatty acid metabolism_Homo sapiens_hsa012120.76720968
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76122088
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.74461339
61Alzheimers disease_Homo sapiens_hsa050100.73874569
62Antigen processing and presentation_Homo sapiens_hsa046120.73080731
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66892186
64Selenocompound metabolism_Homo sapiens_hsa004500.65529528
65Phototransduction_Homo sapiens_hsa047440.65398047
66Rheumatoid arthritis_Homo sapiens_hsa053230.60211106
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60021531
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.57535847
69Fatty acid degradation_Homo sapiens_hsa000710.56163367
70Glycerolipid metabolism_Homo sapiens_hsa005610.51560430
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51235744
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.48237502
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47099181
74Epstein-Barr virus infection_Homo sapiens_hsa051690.46953027
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45911610
76Arginine and proline metabolism_Homo sapiens_hsa003300.45732755
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45631203
78Metabolic pathways_Homo sapiens_hsa011000.44969701
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.44945504
80Cardiac muscle contraction_Homo sapiens_hsa042600.44938663
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43854399
82Retinol metabolism_Homo sapiens_hsa008300.43650640
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42483600
84Pyruvate metabolism_Homo sapiens_hsa006200.42458060
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.42137762
86Fanconi anemia pathway_Homo sapiens_hsa034600.41809170
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39752439
88Chemical carcinogenesis_Homo sapiens_hsa052040.35372640
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35146856
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34662868
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34617753
92Vitamin digestion and absorption_Homo sapiens_hsa049770.34453111
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31626024
94mRNA surveillance pathway_Homo sapiens_hsa030150.30615382
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30210545
96Folate biosynthesis_Homo sapiens_hsa007900.29957984
97Carbon metabolism_Homo sapiens_hsa012000.29882358
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28326733
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27261091
100Arachidonic acid metabolism_Homo sapiens_hsa005900.25982720

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