NPM1P46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.77617542
2cytidine metabolic process (GO:0046087)7.76839688
3cytidine catabolic process (GO:0006216)7.76839688
4cytidine deamination (GO:0009972)7.76839688
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.60065309
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.63574953
7regulation of regulatory T cell differentiation (GO:0045589)5.74291490
8negative regulation by host of viral transcription (GO:0043922)4.70771391
9positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.49719835
10regulation of isotype switching to IgG isotypes (GO:0048302)4.37685816
11regulation of chronic inflammatory response (GO:0002676)4.14529314
12negative regulation of T cell apoptotic process (GO:0070233)4.02460241
13proteasome assembly (GO:0043248)3.97527846
14regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.86992118
15positive regulation of interleukin-8 secretion (GO:2000484)3.78088864
16positive T cell selection (GO:0043368)3.74968488
17positive regulation of defense response to virus by host (GO:0002230)3.67645327
18cellular response to interleukin-15 (GO:0071350)3.67324200
19ribosomal small subunit assembly (GO:0000028)3.63790071
20protein neddylation (GO:0045116)3.58897204
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58501836
22regulation of cellular amino acid metabolic process (GO:0006521)3.55872790
23positive regulation of interleukin-17 production (GO:0032740)3.55321142
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.53273468
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.47852715
26regulation of activation of Janus kinase activity (GO:0010533)3.47235610
27positive thymic T cell selection (GO:0045059)3.46190636
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.39929197
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39880565
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39880565
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39880565
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.36952049
33signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.36952049
34negative regulation of lymphocyte apoptotic process (GO:0070229)3.36349298
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.35369996
36eosinophil chemotaxis (GO:0048245)3.33336189
37regulation of immunoglobulin secretion (GO:0051023)3.32045985
38negative regulation of viral genome replication (GO:0045071)3.28995910
39T cell migration (GO:0072678)3.28215855
40DNA demethylation (GO:0080111)3.27901693
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26265880
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25878668
43negative regulation of ligase activity (GO:0051352)3.25878668
44negative T cell selection (GO:0043383)3.24544985
45ATP synthesis coupled proton transport (GO:0015986)3.22549822
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22549822
47signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21076564
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.21076564
49positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.20635462
50positive regulation of natural killer cell mediated immunity (GO:0002717)3.16109937
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.15986021
52signal transduction involved in cell cycle checkpoint (GO:0072395)3.14882831
53chaperone-mediated protein transport (GO:0072321)3.14753865
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11673028
55positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.09126424
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07864026
57cytolysis (GO:0019835)3.06963201
58regulation of T cell receptor signaling pathway (GO:0050856)3.06721842
59pyrimidine nucleoside catabolic process (GO:0046135)3.05622445
60eosinophil migration (GO:0072677)3.01735209
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00851565
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00640133
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00640133
64positive regulation of DNA recombination (GO:0045911)3.00202753
65positive regulation of calcium-mediated signaling (GO:0050850)2.99474776
66positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98942663
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97790779
68positive regulation of lymphocyte migration (GO:2000403)2.94444752
69macrophage chemotaxis (GO:0048246)2.93088469
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.92117903
71transcription elongation from RNA polymerase III promoter (GO:0006385)2.89630789
72termination of RNA polymerase III transcription (GO:0006386)2.89630789
73Arp2/3 complex-mediated actin nucleation (GO:0034314)2.88005330
74positive regulation of isotype switching (GO:0045830)2.86052217
75response to interleukin-15 (GO:0070672)2.85203991
76positive regulation of tolerance induction (GO:0002645)2.84421885
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83337040
78maturation of SSU-rRNA (GO:0030490)2.81294167
79positive regulation of cell cycle arrest (GO:0071158)2.79065160
80respiratory electron transport chain (GO:0022904)2.79028970
81regulation of interleukin-8 secretion (GO:2000482)2.78657741
82positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78041669
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.77672513
84regulation of lymphocyte chemotaxis (GO:1901623)2.77584574
85electron transport chain (GO:0022900)2.77003495
86positive regulation of cell killing (GO:0031343)2.74324301
87regulation of leukocyte mediated cytotoxicity (GO:0001910)2.72891434
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71719251
89positive regulation of T cell chemotaxis (GO:0010820)2.71635675
90regulation of T cell chemotaxis (GO:0010819)2.71635675
91actin nucleation (GO:0045010)2.70571735
92regulation of natural killer cell mediated immunity (GO:0002715)2.69131560
93regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.69131560
94natural killer cell activation (GO:0030101)2.69128112
95platelet dense granule organization (GO:0060155)2.69032806
96regulation of alpha-beta T cell proliferation (GO:0046640)2.68720999
97protein complex biogenesis (GO:0070271)2.65346597
98regulation of B cell differentiation (GO:0045577)2.64874264
99positive regulation of gamma-delta T cell activation (GO:0046645)2.64493790
100signal peptide processing (GO:0006465)2.64326867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.60066076
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.06078556
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.03981919
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.83651749
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.66256850
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.45256534
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.43226182
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.11630987
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96839485
10VDR_23849224_ChIP-Seq_CD4+_Human2.68742913
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.66016321
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62540437
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.61430369
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56944228
15VDR_22108803_ChIP-Seq_LS180_Human2.53798677
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.44797074
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41541967
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.28421631
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.15694714
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.14748641
21ELK1_19687146_ChIP-ChIP_HELA_Human2.14624508
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10758830
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05677440
24FOXP3_21729870_ChIP-Seq_TREG_Human1.93305651
25ZNF274_21170338_ChIP-Seq_K562_Hela1.89125126
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87777231
27MYB_26560356_Chip-Seq_TH2_Human1.85739792
28MYC_18940864_ChIP-ChIP_HL60_Human1.85323974
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82009158
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80501006
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61629533
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.60799605
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.59553387
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.58509824
35EWS_26573619_Chip-Seq_HEK293_Human1.52625489
36GATA3_26560356_Chip-Seq_TH2_Human1.51333242
37TP53_22573176_ChIP-Seq_HFKS_Human1.50867380
38GATA3_27048872_Chip-Seq_THYMUS_Human1.48457426
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46916472
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37895057
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37777235
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36311061
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36302392
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34470970
45PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.33482710
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32759725
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32105902
48RUNX_20019798_ChIP-Seq_JUKART_Human1.30030531
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.26811403
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26811403
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.26414868
52IGF1R_20145208_ChIP-Seq_DFB_Human1.25721613
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25647360
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24172574
55ER_23166858_ChIP-Seq_MCF-7_Human1.20954797
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19881460
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19269645
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18164449
59FUS_26573619_Chip-Seq_HEK293_Human1.17203390
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17123840
61AR_20517297_ChIP-Seq_VCAP_Human1.14726337
62HTT_18923047_ChIP-ChIP_STHdh_Human1.12734975
63TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12721204
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12029579
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10468456
66NCOR_22424771_ChIP-Seq_293T_Human1.09843560
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08731908
68TTF2_22483619_ChIP-Seq_HELA_Human1.08630068
69TAF15_26573619_Chip-Seq_HEK293_Human1.08309558
70SOX2_19829295_ChIP-Seq_ESCs_Human1.07180968
71NANOG_19829295_ChIP-Seq_ESCs_Human1.07180968
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.06582906
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.05143075
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04541207
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04409219
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02890929
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01813325
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00510439
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97410833
80MYB_26560356_Chip-Seq_TH1_Human0.96160205
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96132830
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96005653
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95081698
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95077691
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94484594
86P300_19829295_ChIP-Seq_ESCs_Human0.94045935
87GATA3_26560356_Chip-Seq_TH1_Human0.93541208
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93210717
89DCP1A_22483619_ChIP-Seq_HELA_Human0.93183193
90CBP_20019798_ChIP-Seq_JUKART_Human0.92240959
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92240959
92TAF2_19829295_ChIP-Seq_ESCs_Human0.91753620
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91154207
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.90455762
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.90455304
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90160687
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.88989376
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88816909
99IRF1_19129219_ChIP-ChIP_H3396_Human0.88600192
100NANOG_20526341_ChIP-Seq_ESCs_Human0.88209314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.62889651
2MP0001835_abnormal_antigen_presentation3.95321843
3MP0003763_abnormal_thymus_physiology2.92997336
4MP0009785_altered_susceptibility_to2.81566151
5MP0009333_abnormal_splenocyte_physiolog2.78166082
6MP0003786_premature_aging2.72798388
7MP0001873_stomach_inflammation2.61989640
8MP0002148_abnormal_hypersensitivity_rea2.29336924
9MP0001790_abnormal_immune_system2.11876869
10MP0005387_immune_system_phenotype2.11876869
11MP0002138_abnormal_hepatobiliary_system2.10903692
12MP0001800_abnormal_humoral_immune2.07014482
13MP0005000_abnormal_immune_tolerance2.00624224
14MP0001853_heart_inflammation1.98554880
15MP0006082_CNS_inflammation1.95536415
16MP0002166_altered_tumor_susceptibility1.95091182
17MP0009379_abnormal_foot_pigmentation1.91011147
18MP0003806_abnormal_nucleotide_metabolis1.90500689
19MP0002006_tumorigenesis1.85706604
20MP0000685_abnormal_immune_system1.82426801
21MP0004145_abnormal_muscle_electrophysio1.78037884
22MP0002102_abnormal_ear_morphology1.76864302
23MP0002420_abnormal_adaptive_immunity1.76172661
24MP0002723_abnormal_immune_serum1.74647543
25MP0003195_calcinosis1.74139492
26MP0004147_increased_porphyrin_level1.73737482
27MP0001819_abnormal_immune_cell1.70867202
28MP0005025_abnormal_response_to1.67369422
29MP0003866_abnormal_defecation1.66873078
30MP0002405_respiratory_system_inflammati1.58716854
31MP0001188_hyperpigmentation1.55358772
32MP0005084_abnormal_gallbladder_morpholo1.54252942
33MP0008058_abnormal_DNA_repair1.53926631
34MP0008877_abnormal_DNA_methylation1.52478801
35MP0006072_abnormal_retinal_apoptosis1.50660417
36MP0002398_abnormal_bone_marrow1.46855696
37MP0008995_early_reproductive_senescence1.46130871
38MP0002452_abnormal_antigen_presenting1.42154450
39MP0002277_abnormal_respiratory_mucosa1.42053966
40MP0008875_abnormal_xenobiotic_pharmacok1.40111470
41MP0000716_abnormal_immune_system1.38203781
42MP0000703_abnormal_thymus_morphology1.35349029
43MP0008872_abnormal_physiological_respon1.33698426
44MP0010155_abnormal_intestine_physiology1.29876451
45MP0000689_abnormal_spleen_morphology1.29657447
46MP0005075_abnormal_melanosome_morpholog1.28287061
47MP0000372_irregular_coat_pigmentation1.27709599
48MP0001661_extended_life_span1.27535297
49MP0000465_gastrointestinal_hemorrhage1.27001644
50MP0002234_abnormal_pharynx_morphology1.26039518
51MP0002722_abnormal_immune_system1.25910957
52MP0003045_fibrosis1.19072466
53MP0005389_reproductive_system_phenotype1.18709056
54MP0003448_altered_tumor_morphology1.17444415
55MP0001845_abnormal_inflammatory_respons1.13680880
56MP0004957_abnormal_blastocyst_morpholog1.12938326
57MP0003878_abnormal_ear_physiology1.12834962
58MP0005377_hearing/vestibular/ear_phenot1.12834962
59MP0009697_abnormal_copulation1.12279789
60MP0002429_abnormal_blood_cell1.12267142
61MP0002876_abnormal_thyroid_physiology1.11393137
62MP0001919_abnormal_reproductive_system1.11250880
63MP0005360_urolithiasis1.10867021
64MP0003646_muscle_fatigue1.06155054
65MP0002693_abnormal_pancreas_physiology1.05595309
66MP0003880_abnormal_central_pattern1.03258493
67MP0003567_abnormal_fetal_cardiomyocyte1.02741715
68MP0003011_delayed_dark_adaptation1.01353523
69MP0006292_abnormal_olfactory_placode1.00851704
70MP0002163_abnormal_gland_morphology1.00688927
71MP0010094_abnormal_chromosome_stability1.00681037
72MP0003693_abnormal_embryo_hatching0.99138122
73MP0002933_joint_inflammation0.98629602
74MP0005551_abnormal_eye_electrophysiolog0.98306886
75MP0002160_abnormal_reproductive_system0.98082817
76MP0001501_abnormal_sleep_pattern0.97597930
77MP0005253_abnormal_eye_physiology0.96888644
78MP0005645_abnormal_hypothalamus_physiol0.96232705
79MP0001905_abnormal_dopamine_level0.94637943
80MP0006036_abnormal_mitochondrial_physio0.94228625
81MP0001968_abnormal_touch/_nociception0.92342257
82MP0002837_dystrophic_cardiac_calcinosis0.92117836
83MP0002736_abnormal_nociception_after0.91407008
84MP0001984_abnormal_olfaction0.90889167
85MP0005379_endocrine/exocrine_gland_phen0.88750331
86MP0001119_abnormal_female_reproductive0.87198631
87MP0003718_maternal_effect0.86972544
88MP0008469_abnormal_protein_level0.84776097
89MP0002095_abnormal_skin_pigmentation0.83485053
90MP0002019_abnormal_tumor_incidence0.78758129
91MP0002210_abnormal_sex_determination0.77562572
92MP0005410_abnormal_fertilization0.72501470
93MP0005083_abnormal_biliary_tract0.71698293
94MP0005310_abnormal_salivary_gland0.71537158
95MP0004043_abnormal_pH_regulation0.69902491
96MP0004381_abnormal_hair_follicle0.69244255
97MP0003724_increased_susceptibility_to0.67425309
98MP0002419_abnormal_innate_immunity0.66928490
99MP0001929_abnormal_gametogenesis0.66741812
100MP0009763_increased_sensitivity_to0.65404106

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.82941203
2Aplastic anemia (HP:0001915)4.64719091
3Abnormality of T cell number (HP:0011839)4.62344586
4IgG deficiency (HP:0004315)4.40368256
5Elevated erythrocyte sedimentation rate (HP:0003565)4.36713599
6Severe combined immunodeficiency (HP:0004430)3.92125608
73-Methylglutaconic aciduria (HP:0003535)3.88210871
8Stomatitis (HP:0010280)3.78559451
9Hypoproteinemia (HP:0003075)3.74641713
10Mitochondrial inheritance (HP:0001427)3.64376621
11Congenital, generalized hypertrichosis (HP:0004540)3.58948900
12Acute necrotizing encephalopathy (HP:0006965)3.42633371
13Increased hepatocellular lipid droplets (HP:0006565)3.41955061
14Abnormality of T cells (HP:0002843)3.38998663
15Increased CSF lactate (HP:0002490)3.38868652
16Thyroiditis (HP:0100646)3.15299467
17Lipid accumulation in hepatocytes (HP:0006561)3.09939246
18Hepatocellular necrosis (HP:0001404)3.06798499
19Increased IgM level (HP:0003496)3.05905217
20Combined immunodeficiency (HP:0005387)3.05077835
21Abnormal mitochondria in muscle tissue (HP:0008316)2.98508591
22Increased intramyocellular lipid droplets (HP:0012240)2.94671587
23Hepatic necrosis (HP:0002605)2.91260302
24Renal Fanconi syndrome (HP:0001994)2.89671257
25Congenital stationary night blindness (HP:0007642)2.82790017
26Autoimmune hemolytic anemia (HP:0001890)2.81851803
27Pancreatic cysts (HP:0001737)2.81544034
28Acute encephalopathy (HP:0006846)2.80286195
29Progressive macrocephaly (HP:0004481)2.80274046
30Abnormality of eosinophils (HP:0001879)2.79770317
31Abnormality of the prostate (HP:0008775)2.70826102
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67021260
33Increased serum lactate (HP:0002151)2.57280523
34Methylmalonic acidemia (HP:0002912)2.53652440
35Generalized aminoaciduria (HP:0002909)2.53252447
36Abnormality of midbrain morphology (HP:0002418)2.49356865
37Molar tooth sign on MRI (HP:0002419)2.49356865
38Abolished electroretinogram (ERG) (HP:0000550)2.43091336
39Hypoalbuminemia (HP:0003073)2.41848471
40Abnormal albumin level (HP:0012116)2.41848471
41Renal cortical cysts (HP:0000803)2.40514278
42Increased muscle lipid content (HP:0009058)2.38628229
43Cerebral edema (HP:0002181)2.38509960
44Exertional dyspnea (HP:0002875)2.37251862
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34970250
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34970250
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34890402
48Abnormality of B cell number (HP:0010975)2.29671338
49Pancytopenia (HP:0001876)2.28349434
50Recurrent bronchitis (HP:0002837)2.28091844
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.27463612
52Abnormality of alanine metabolism (HP:0010916)2.26399682
53Hyperalaninemia (HP:0003348)2.26399682
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26399682
55Eosinophilia (HP:0001880)2.24837727
56Methylmalonic aciduria (HP:0012120)2.24613748
57Type II lissencephaly (HP:0007260)2.24153935
58Abnormal rod and cone electroretinograms (HP:0008323)2.23952796
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23398673
60B lymphocytopenia (HP:0010976)2.20639695
61Optic disc pallor (HP:0000543)2.19659561
62True hermaphroditism (HP:0010459)2.19015668
63Encephalitis (HP:0002383)2.17259207
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16222847
65Panhypogammaglobulinemia (HP:0003139)2.15056721
66Lactic acidosis (HP:0003128)2.13299613
67Constricted visual fields (HP:0001133)2.12833323
68Abnormality of T cell physiology (HP:0011840)2.10170712
69IgM deficiency (HP:0002850)2.10140483
70Chronic mucocutaneous candidiasis (HP:0002728)2.09191135
71Recurrent cutaneous fungal infections (HP:0011370)2.09191135
72Abnormality of urine glucose concentration (HP:0011016)2.07649197
73Glycosuria (HP:0003076)2.07649197
74Colon cancer (HP:0003003)2.07473452
75Chronic diarrhea (HP:0002028)2.06935006
76Abnormality of the pons (HP:0007361)2.06917338
77Lethargy (HP:0001254)1.94903433
78Lymphopenia (HP:0001888)1.94844538
79Type I transferrin isoform profile (HP:0003642)1.93697086
80Cerebellar dysplasia (HP:0007033)1.88648846
81Hypoplasia of the pons (HP:0012110)1.85529666
82Lymphoma (HP:0002665)1.84821554
83Abnormality of the renal cortex (HP:0011035)1.82776042
84Pancreatic fibrosis (HP:0100732)1.82401193
85Agammaglobulinemia (HP:0004432)1.82238342
86Abnormality of cells of the lymphoid lineage (HP:0012140)1.82206624
87Respiratory failure (HP:0002878)1.80822532
88Nephronophthisis (HP:0000090)1.80148367
89Hypoplasia of the thymus (HP:0000778)1.78740585
90Dicarboxylic aciduria (HP:0003215)1.78553619
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78553619
92Leukocytosis (HP:0001974)1.77666211
93Autoimmune thrombocytopenia (HP:0001973)1.77538904
94Attenuation of retinal blood vessels (HP:0007843)1.74572367
95Decreased central vision (HP:0007663)1.74132346
96Recurrent viral infections (HP:0004429)1.71288705
97Palpitations (HP:0001962)1.70604983
98Aplasia/hypoplasia of the uterus (HP:0008684)1.69565020
99Exercise intolerance (HP:0003546)1.68997180
100Absent thumb (HP:0009777)1.68961106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.38002190
2KDR3.54432983
3VRK23.30776956
4ZAK2.80424220
5TESK22.70725674
6EIF2AK32.68707080
7TAOK32.60991137
8BUB12.59582006
9NUAK12.29196901
10ADRBK22.29189288
11ITK2.25112324
12BCKDK2.10465551
13MST42.03908357
14MAP4K11.96996678
15TLK11.91112957
16VRK11.90543941
17BMPR1B1.88500080
18TEC1.82851598
19GRK11.71497661
20TSSK61.57077601
21NME11.53520837
22PASK1.53309821
23EIF2AK11.36243399
24WNK41.29415284
25FRK1.22416214
26NEK11.18122104
27STK161.16282126
28MAPKAPK31.14337988
29MAP4K21.12526374
30PBK1.09419202
31PRKCQ1.09016371
32CSK1.07772561
33SYK1.07631464
34FES1.07177961
35TAF11.05507919
36PLK31.04896092
37NLK1.04833386
38LCK1.01851320
39BTK0.99036641
40SRPK10.97584392
41LIMK10.94627223
42MAP2K60.93132270
43TGFBR10.89539055
44WNK30.87851967
45IKBKE0.87554756
46IKBKB0.85271985
47TRIM280.81942237
48MUSK0.81532318
49GRK70.78010147
50EIF2AK20.76960221
51INSRR0.76195068
52MAPKAPK50.69042382
53PLK40.67334975
54TIE10.65197051
55TNK20.62311024
56CDK190.62310804
57TESK10.61559529
58MKNK10.61100395
59KIT0.61029743
60SCYL20.59448801
61DAPK10.59093174
62RPS6KA50.58215470
63LYN0.57575248
64CDC70.56843835
65CDK80.55551522
66OXSR10.54616562
67ZAP700.53808453
68WEE10.52712917
69ATR0.50553684
70STK390.50050034
71MYLK0.49575759
72PLK20.48300440
73CAMKK20.46729917
74PIK3CA0.46214936
75MAP3K120.45010550
76ADRBK10.43916377
77JAK30.42863049
78PINK10.42814228
79IGF1R0.42793084
80RPS6KA40.41659092
81PIK3CG0.40086904
82CSNK2A10.39046946
83CSNK1G10.38721520
84GRK60.38434517
85OBSCN0.38261020
86PLK10.37408679
87CSNK2A20.36024625
88PHKG20.34320276
89PHKG10.34320276
90FGFR10.34042337
91CDK30.33687844
92ALK0.33515427
93PDK20.32593092
94PRKCA0.32381700
95AURKB0.30895845
96BCR0.30416004
97PIM10.29333861
98CSF1R0.28000100
99AURKA0.27713026
100DAPK20.26901999

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.94592881
2Primary immunodeficiency_Homo sapiens_hsa053404.42885118
3Autoimmune thyroid disease_Homo sapiens_hsa053203.04451199
4Allograft rejection_Homo sapiens_hsa053302.95217507
5Oxidative phosphorylation_Homo sapiens_hsa001902.86612098
6Graft-versus-host disease_Homo sapiens_hsa053322.74802766
7Protein export_Homo sapiens_hsa030602.71333558
8Ribosome_Homo sapiens_hsa030102.69128534
9RNA polymerase_Homo sapiens_hsa030202.48198146
10Parkinsons disease_Homo sapiens_hsa050122.41478517
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37429774
12Antigen processing and presentation_Homo sapiens_hsa046122.33297139
13Type I diabetes mellitus_Homo sapiens_hsa049402.32178705
14Hematopoietic cell lineage_Homo sapiens_hsa046402.05543005
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.97772223
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84140874
17Asthma_Homo sapiens_hsa053101.83855128
18T cell receptor signaling pathway_Homo sapiens_hsa046601.82917643
19Rheumatoid arthritis_Homo sapiens_hsa053231.63139490
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56953888
21Homologous recombination_Homo sapiens_hsa034401.52313618
22Huntingtons disease_Homo sapiens_hsa050161.47967889
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47656646
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44875329
25Alzheimers disease_Homo sapiens_hsa050101.44110653
26DNA replication_Homo sapiens_hsa030301.43668475
27RNA degradation_Homo sapiens_hsa030181.39249062
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37281755
29Mismatch repair_Homo sapiens_hsa034301.32384497
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31990550
31One carbon pool by folate_Homo sapiens_hsa006701.29108096
32Linoleic acid metabolism_Homo sapiens_hsa005911.20612049
33Propanoate metabolism_Homo sapiens_hsa006401.19582728
34Nucleotide excision repair_Homo sapiens_hsa034201.16057399
35Basal transcription factors_Homo sapiens_hsa030221.11960702
36Phototransduction_Homo sapiens_hsa047441.09714997
37Caffeine metabolism_Homo sapiens_hsa002321.08453727
38RNA transport_Homo sapiens_hsa030131.06975424
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06606325
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.05456696
41Pyrimidine metabolism_Homo sapiens_hsa002401.04674306
42Fanconi anemia pathway_Homo sapiens_hsa034601.02083761
43Measles_Homo sapiens_hsa051621.01471639
44Spliceosome_Homo sapiens_hsa030400.99985520
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96656157
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93183100
47Purine metabolism_Homo sapiens_hsa002300.92319180
48Nitrogen metabolism_Homo sapiens_hsa009100.88858386
49Cardiac muscle contraction_Homo sapiens_hsa042600.88767469
50Butanoate metabolism_Homo sapiens_hsa006500.85278993
51Peroxisome_Homo sapiens_hsa041460.82430757
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81272724
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79638440
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76112412
55Regulation of autophagy_Homo sapiens_hsa041400.74318997
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73214361
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70665671
58Tryptophan metabolism_Homo sapiens_hsa003800.64037648
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.60518310
60Ether lipid metabolism_Homo sapiens_hsa005650.59437600
61Viral myocarditis_Homo sapiens_hsa054160.58093251
62Systemic lupus erythematosus_Homo sapiens_hsa053220.55384335
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52912673
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.52387957
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51347442
66Sulfur metabolism_Homo sapiens_hsa009200.50250522
67Non-homologous end-joining_Homo sapiens_hsa034500.49024702
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46968238
69Base excision repair_Homo sapiens_hsa034100.45697840
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45034878
71Retinol metabolism_Homo sapiens_hsa008300.43949474
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42140907
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41369498
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41036325
75Salmonella infection_Homo sapiens_hsa051320.40760484
76Chemical carcinogenesis_Homo sapiens_hsa052040.39130921
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38466257
78Metabolic pathways_Homo sapiens_hsa011000.38156557
79Epstein-Barr virus infection_Homo sapiens_hsa051690.38087454
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37343812
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.37113989
82Herpes simplex infection_Homo sapiens_hsa051680.36638421
83Olfactory transduction_Homo sapiens_hsa047400.36009401
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.35382240
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.33800690
86Malaria_Homo sapiens_hsa051440.32846113
87African trypanosomiasis_Homo sapiens_hsa051430.32092866
88Fatty acid elongation_Homo sapiens_hsa000620.30384162
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29344011
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25634881
91Folate biosynthesis_Homo sapiens_hsa007900.25437779
92HTLV-I infection_Homo sapiens_hsa051660.25309879
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24792899
94mRNA surveillance pathway_Homo sapiens_hsa030150.24276816
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22829967
96Arachidonic acid metabolism_Homo sapiens_hsa005900.22700626
97Shigellosis_Homo sapiens_hsa051310.22378021
98Mineral absorption_Homo sapiens_hsa049780.20545224
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19608556
100Taste transduction_Homo sapiens_hsa047420.19255437

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