NPM1P47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)8.19954820
2positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)7.17579514
3regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.46592544
4positive regulation of vesicle fusion (GO:0031340)5.89855586
5positive regulation of amino acid transport (GO:0051957)5.72676558
6positive regulation of cell fate commitment (GO:0010455)5.59515277
7regulation of isotype switching to IgG isotypes (GO:0048302)5.50986241
8regulation of timing of cell differentiation (GO:0048505)5.37961273
9DNA deamination (GO:0045006)4.90118277
10regulation of development, heterochronic (GO:0040034)4.60149499
11regulation of podosome assembly (GO:0071801)4.31225331
12positive regulation of DNA recombination (GO:0045911)4.10820582
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.04444442
14astrocyte differentiation (GO:0048708)4.04106634
15water-soluble vitamin biosynthetic process (GO:0042364)4.04081042
16positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.96238449
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.93650994
18hindbrain development (GO:0030902)3.87646448
19growth hormone receptor signaling pathway (GO:0060396)3.87422383
20negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.87012942
21rRNA catabolic process (GO:0016075)3.85973859
22regulation of B cell apoptotic process (GO:0002902)3.82874442
23positive regulation of isotype switching (GO:0045830)3.81013228
24rRNA modification (GO:0000154)3.76266261
25regulation of immunoglobulin secretion (GO:0051023)3.73624145
26GTP biosynthetic process (GO:0006183)3.72918316
27cullin deneddylation (GO:0010388)3.68388990
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64422995
29proteasome assembly (GO:0043248)3.54837479
30ribosome assembly (GO:0042255)3.52762726
31positive regulation of defense response to virus by host (GO:0002230)3.51723051
32regulation of chronic inflammatory response (GO:0002676)3.46819848
33cellular response to growth hormone stimulus (GO:0071378)3.46291309
34maturation of 5.8S rRNA (GO:0000460)3.43951999
35positive regulation of organic acid transport (GO:0032892)3.38062438
36dorsal/ventral axis specification (GO:0009950)3.37524880
37synapsis (GO:0007129)3.34435790
38rRNA methylation (GO:0031167)3.31343524
39UTP biosynthetic process (GO:0006228)3.28633277
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.27544069
41NADH dehydrogenase complex assembly (GO:0010257)3.27544069
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27544069
43regulation of gene expression by genetic imprinting (GO:0006349)3.23655254
44CTP metabolic process (GO:0046036)3.22323234
45CTP biosynthetic process (GO:0006241)3.22323234
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.20957167
47negative regulation of B cell apoptotic process (GO:0002903)3.17432483
48protein neddylation (GO:0045116)3.17159542
49DNA catabolic process, exonucleolytic (GO:0000738)3.13122188
50pseudouridine synthesis (GO:0001522)3.09846069
51protein deneddylation (GO:0000338)3.09066765
52protein complex biogenesis (GO:0070271)3.09022760
53regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06230697
54regulation of MHC class II biosynthetic process (GO:0045346)3.02325072
55UTP metabolic process (GO:0046051)3.02098230
56somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.94711574
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.94711574
58isotype switching (GO:0045190)2.94711574
59pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.93150432
60alpha-beta T cell differentiation involved in immune response (GO:0002293)2.91523157
61alpha-beta T cell activation involved in immune response (GO:0002287)2.91523157
62T cell differentiation involved in immune response (GO:0002292)2.91523157
63mitochondrial respiratory chain complex assembly (GO:0033108)2.91252446
64pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.89440502
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88813798
66pituitary gland development (GO:0021983)2.88151145
67CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.87556665
68negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.87447922
69chaperone-mediated protein transport (GO:0072321)2.82098186
70respiratory chain complex IV assembly (GO:0008535)2.81639392
71pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.81469833
72positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.81077922
73signal transduction involved in regulation of gene expression (GO:0023019)2.80456984
74response to pheromone (GO:0019236)2.80421453
75pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.75465811
76positive regulation of chemokine biosynthetic process (GO:0045080)2.75019477
77keratinocyte development (GO:0003334)2.74367229
78positive regulation of organelle assembly (GO:1902117)2.71600204
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71573778
80regulation of calcium ion-dependent exocytosis (GO:0017158)2.69862367
81tyrosine phosphorylation of STAT protein (GO:0007260)2.69608117
82protein peptidyl-prolyl isomerization (GO:0000413)2.68175902
83regulation of regulatory T cell differentiation (GO:0045589)2.67889616
84positive regulation of amine transport (GO:0051954)2.66421596
85establishment of protein localization to mitochondrial membrane (GO:0090151)2.65081223
86regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.64867457
87somatic hypermutation of immunoglobulin genes (GO:0016446)2.64120440
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64120440
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62591866
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61739650
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61739650
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61739650
93pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.61688204
94regulation of isotype switching (GO:0045191)2.60683686
95gland morphogenesis (GO:0022612)2.60406205
96positive regulation of JAK-STAT cascade (GO:0046427)2.60315900
97regulation of cellular amino acid metabolic process (GO:0006521)2.58959177
98rRNA metabolic process (GO:0016072)2.57163123
99S-adenosylmethionine metabolic process (GO:0046500)2.55790375
100pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.55773373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.79584145
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.32158799
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.10688082
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.03706928
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.75737953
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86552316
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77034443
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69829585
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.50710578
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.47775231
11VDR_23849224_ChIP-Seq_CD4+_Human2.40215878
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.22691584
13MYC_18940864_ChIP-ChIP_HL60_Human2.17792106
14ZNF274_21170338_ChIP-Seq_K562_Hela2.17340430
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17046086
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07934160
17SRF_21415370_ChIP-Seq_HL-1_Mouse1.95394363
18E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91216618
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88862168
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86964879
21ELK1_19687146_ChIP-ChIP_HELA_Human1.85425839
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81430793
23FOXP3_21729870_ChIP-Seq_TREG_Human1.81371256
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78832135
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77482194
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71705404
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71521698
28TAF15_26573619_Chip-Seq_HEK293_Human1.66110645
29EWS_26573619_Chip-Seq_HEK293_Human1.65721697
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64201801
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57509895
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.57379500
33TP53_22573176_ChIP-Seq_HFKS_Human1.56118182
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47996661
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45422272
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45402343
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45255079
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44750097
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42973136
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.38379633
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.38319989
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35955108
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.35955108
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.33423982
45VDR_22108803_ChIP-Seq_LS180_Human1.32371525
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27241927
47HTT_18923047_ChIP-ChIP_STHdh_Human1.24495796
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23654168
49NANOG_19829295_ChIP-Seq_ESCs_Human1.22422908
50SOX2_19829295_ChIP-Seq_ESCs_Human1.22422908
51AR_20517297_ChIP-Seq_VCAP_Human1.21501928
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19450947
53P300_19829295_ChIP-Seq_ESCs_Human1.19321810
54TTF2_22483619_ChIP-Seq_HELA_Human1.18070629
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16639516
56DCP1A_22483619_ChIP-Seq_HELA_Human1.14975378
57ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14736357
58GATA3_26560356_Chip-Seq_TH2_Human1.14339417
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.14293019
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13520656
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12489685
62CBP_20019798_ChIP-Seq_JUKART_Human1.12489685
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12132791
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11554558
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11129287
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10236160
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06929758
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06517660
69NCOR_22424771_ChIP-Seq_293T_Human1.05418588
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04623271
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.04346450
72FUS_26573619_Chip-Seq_HEK293_Human1.02751960
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01379660
74PHF8_20622853_ChIP-Seq_HELA_Human0.98464795
75ERA_21632823_ChIP-Seq_H3396_Human0.98158173
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95885533
77PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95511618
78YY1_21170310_ChIP-Seq_MESCs_Mouse0.95335755
79BCAT_22108803_ChIP-Seq_LS180_Human0.94308415
80CRX_20693478_ChIP-Seq_RETINA_Mouse0.93594268
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93340446
82GATA3_21878914_ChIP-Seq_MCF-7_Human0.92707642
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92669384
84NANOG_20526341_ChIP-Seq_ESCs_Human0.92182699
85GABP_19822575_ChIP-Seq_HepG2_Human0.91209631
86GATA6_21074721_ChIP-Seq_CACO-2_Human0.89482160
87TAF2_19829295_ChIP-Seq_ESCs_Human0.88469961
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88171860
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.87719362
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87420814
91HOXB7_26014856_ChIP-Seq_BT474_Human0.87253993
92SMAD4_21741376_ChIP-Seq_EPCs_Human0.86536630
93ER_23166858_ChIP-Seq_MCF-7_Human0.86462402
94CDX2_22108803_ChIP-Seq_LS180_Human0.85672640
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83965954
96LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83635989
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82977015
98IRF1_19129219_ChIP-ChIP_H3396_Human0.81684795
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81518977
100ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80920276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode7.67508707
2MP0005257_abnormal_intraocular_pressure4.50625290
3MP0002102_abnormal_ear_morphology4.16464886
4MP0002638_abnormal_pupillary_reflex4.01504606
5MP0002938_white_spotting3.52623894
6MP0002837_dystrophic_cardiac_calcinosis3.38484579
7MP0008877_abnormal_DNA_methylation3.35823494
8MP0001873_stomach_inflammation3.30428299
9MP0008789_abnormal_olfactory_epithelium3.21571310
10MP0001835_abnormal_antigen_presentation3.04731066
11MP0006036_abnormal_mitochondrial_physio2.46026908
12MP0000613_abnormal_salivary_gland2.42744303
13MP0005394_taste/olfaction_phenotype2.37039972
14MP0005499_abnormal_olfactory_system2.37039972
15MP0003787_abnormal_imprinting2.35935869
16MP0002138_abnormal_hepatobiliary_system2.32094626
17MP0002160_abnormal_reproductive_system1.93715616
18MP0005379_endocrine/exocrine_gland_phen1.87744053
19MP0003646_muscle_fatigue1.82402159
20MP0005084_abnormal_gallbladder_morpholo1.72299211
21MP0001968_abnormal_touch/_nociception1.70268113
22MP0008875_abnormal_xenobiotic_pharmacok1.67063894
23MP0005646_abnormal_pituitary_gland1.55959100
24MP0002693_abnormal_pancreas_physiology1.52437160
25MP0003011_delayed_dark_adaptation1.43735407
26MP0000372_irregular_coat_pigmentation1.43204581
27MP0005671_abnormal_response_to1.37991957
28MP0001919_abnormal_reproductive_system1.36725966
29MP0000685_abnormal_immune_system1.34363542
30MP0005389_reproductive_system_phenotype1.29459917
31MP0004782_abnormal_surfactant_physiolog1.29096348
32MP0002148_abnormal_hypersensitivity_rea1.27115207
33MP0001764_abnormal_homeostasis1.24067198
34MP0008872_abnormal_physiological_respon1.23448400
35MP0005645_abnormal_hypothalamus_physiol1.23153660
36MP0004145_abnormal_muscle_electrophysio1.18792164
37MP0001944_abnormal_pancreas_morphology1.17820811
38MP0005636_abnormal_mineral_homeostasis1.17398108
39MP0001501_abnormal_sleep_pattern1.17316799
40MP0003186_abnormal_redox_activity1.11844634
41MP0006072_abnormal_retinal_apoptosis1.10981968
42MP0003786_premature_aging1.10253420
43MP0005410_abnormal_fertilization1.08588555
44MP0005332_abnormal_amino_acid1.08324973
45MP0009046_muscle_twitch1.08303443
46MP0001881_abnormal_mammary_gland1.08299958
47MP0008058_abnormal_DNA_repair1.06853862
48MP0001756_abnormal_urination1.06409851
49MP0005075_abnormal_melanosome_morpholog1.01464935
50MP0010094_abnormal_chromosome_stability1.01220863
51MP0002736_abnormal_nociception_after1.00595660
52MP0004043_abnormal_pH_regulation0.99438398
53MP0004885_abnormal_endolymph0.98848459
54MP0002876_abnormal_thyroid_physiology0.97499915
55MP0002163_abnormal_gland_morphology0.97138097
56MP0000383_abnormal_hair_follicle0.95155687
57MP0008057_abnormal_DNA_replication0.94799562
58MP0008007_abnormal_cellular_replicative0.94640107
59MP0009333_abnormal_splenocyte_physiolog0.92919436
60MP0001348_abnormal_lacrimal_gland0.92332204
61MP0005387_immune_system_phenotype0.91273963
62MP0001790_abnormal_immune_system0.91273963
63MP0009785_altered_susceptibility_to0.88964080
64MP0004147_increased_porphyrin_level0.88778854
65MP0005408_hypopigmentation0.86856181
66MP0003195_calcinosis0.86445845
67MP0005551_abnormal_eye_electrophysiolog0.80966351
68MP0004142_abnormal_muscle_tone0.80876235
69MP0010678_abnormal_skin_adnexa0.78335270
70MP0004957_abnormal_blastocyst_morpholog0.77958944
71MP0003718_maternal_effect0.76918555
72MP0005448_abnormal_energy_balance0.74918758
73MP0001800_abnormal_humoral_immune0.73838280
74MP0001765_abnormal_ion_homeostasis0.73317368
75MP0005253_abnormal_eye_physiology0.71808676
76MP0005220_abnormal_exocrine_pancreas0.71208482
77MP0002177_abnormal_outer_ear0.68703214
78MP0003878_abnormal_ear_physiology0.68042645
79MP0005377_hearing/vestibular/ear_phenot0.68042645
80MP0000631_abnormal_neuroendocrine_gland0.67199153
81MP0001186_pigmentation_phenotype0.65491798
82MP0006035_abnormal_mitochondrial_morpho0.65415653
83MP0003567_abnormal_fetal_cardiomyocyte0.63814597
84MP0000371_diluted_coat_color0.63436610
85MP0003137_abnormal_impulse_conducting0.63207932
86MP0009643_abnormal_urine_homeostasis0.60870209
87MP0010155_abnormal_intestine_physiology0.60635818
88MP0003950_abnormal_plasma_membrane0.57915793
89MP0002405_respiratory_system_inflammati0.57522076
90MP0001663_abnormal_digestive_system0.55984788
91MP0002277_abnormal_respiratory_mucosa0.55718732
92MP0002272_abnormal_nervous_system0.54878534
93MP0001929_abnormal_gametogenesis0.54841595
94MP0002234_abnormal_pharynx_morphology0.54734647
95MP0002735_abnormal_chemical_nociception0.54674084
96MP0010386_abnormal_urinary_bladder0.54432033
97MP0003866_abnormal_defecation0.53228078
98MP0005000_abnormal_immune_tolerance0.53055894
99MP0001324_abnormal_eye_pigmentation0.52351270
100MP0002282_abnormal_trachea_morphology0.52106937

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)7.26574868
2Hypoplasia of the fovea (HP:0007750)7.26574868
3Abnormality of the fovea (HP:0000493)5.89131967
4Aplasia/Hypoplasia of the macula (HP:0008059)4.88307633
5Aplasia/Hypoplasia affecting the retina (HP:0008061)4.54813214
6Stomatitis (HP:0010280)4.53996847
7Acute necrotizing encephalopathy (HP:0006965)3.40698026
8Increased CSF lactate (HP:0002490)3.34223889
9Exertional dyspnea (HP:0002875)3.24979340
10Hepatic necrosis (HP:0002605)3.23000383
11Optic nerve coloboma (HP:0000588)3.22202151
12Cerebral hemorrhage (HP:0001342)3.20984940
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17190714
14Abnormality of alanine metabolism (HP:0010916)3.17190714
15Hyperalaninemia (HP:0003348)3.17190714
16Methylmalonic acidemia (HP:0002912)3.16668311
17Mitochondrial inheritance (HP:0001427)3.13615771
18Optic nerve hypoplasia (HP:0000609)3.03386877
19Spontaneous abortion (HP:0005268)2.99452368
20Hepatocellular necrosis (HP:0001404)2.93478932
21Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.91636275
22Acute encephalopathy (HP:0006846)2.86057254
23Abnormal mitochondria in muscle tissue (HP:0008316)2.85996222
24Gastrointestinal infarctions (HP:0005244)2.85545031
25Renal cortical cysts (HP:0000803)2.82486314
26Methylmalonic aciduria (HP:0012120)2.79739082
27Cerebral edema (HP:0002181)2.76927319
28Progressive macrocephaly (HP:0004481)2.73630150
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67416181
30Abnormality of T cell physiology (HP:0011840)2.65652850
31Abnormality of the renal cortex (HP:0011035)2.65184901
32IgG deficiency (HP:0004315)2.55151853
33Pendular nystagmus (HP:0012043)2.55021909
34Increased serum lactate (HP:0002151)2.50018059
35Fatigue (HP:0012378)2.43541765
36Decreased central vision (HP:0007663)2.42211608
37Decreased circulating renin level (HP:0003351)2.37181042
38Generalized aminoaciduria (HP:0002909)2.33163343
39Adactyly (HP:0009776)2.32476486
40Keratitis (HP:0000491)2.31651744
41Congenital stationary night blindness (HP:0007642)2.26232404
42Abnormal rod and cone electroretinograms (HP:0008323)2.25861632
43IgA deficiency (HP:0002720)2.25681767
44Biliary tract neoplasm (HP:0100574)2.22480875
45Abnormality of the pons (HP:0007361)2.21092472
46Difficulty running (HP:0009046)2.20221494
47Hypoplasia of the pons (HP:0012110)2.19012146
48Abnormality of the anterior horn cell (HP:0006802)2.18986464
49Degeneration of anterior horn cells (HP:0002398)2.18986464
50Hypomagnesemia (HP:0002917)2.16459470
51Abnormality of vitamin B metabolism (HP:0004340)2.13216083
52Progressive inability to walk (HP:0002505)2.11147343
53Panhypogammaglobulinemia (HP:0003139)2.11049500
54Respiratory failure (HP:0002878)2.07919920
55Lipid accumulation in hepatocytes (HP:0006561)2.06544835
56Optic disc pallor (HP:0000543)2.04945270
57Neutropenia (HP:0001875)2.00488457
58Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.99174006
59Inability to walk (HP:0002540)1.97677495
60Pancreatic cysts (HP:0001737)1.97176533
61Intellectual disability, profound (HP:0002187)1.96917416
62Oligodactyly (hands) (HP:0001180)1.95858124
63Lactic acidosis (HP:0003128)1.92217916
64Increased hepatocellular lipid droplets (HP:0006565)1.91347993
65Arterial thrombosis (HP:0004420)1.87876637
66Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87353100
67Dicarboxylic aciduria (HP:0003215)1.87353100
683-Methylglutaconic aciduria (HP:0003535)1.85353074
69Gliosis (HP:0002171)1.85001714
70Retrobulbar optic neuritis (HP:0100654)1.83870079
71Optic neuritis (HP:0100653)1.83870079
72Hypoglycemic coma (HP:0001325)1.83808966
73Spinal muscular atrophy (HP:0007269)1.83384292
74Constricted visual fields (HP:0001133)1.83089776
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82904407
76Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82904407
77Abnormal delayed hypersensitivity skin test (HP:0002963)1.82281481
78Glycosuria (HP:0003076)1.79637854
79Abnormality of urine glucose concentration (HP:0011016)1.79637854
80Abnormality of T cells (HP:0002843)1.78224182
81Amaurosis fugax (HP:0100576)1.76893895
82Thrombocytosis (HP:0001894)1.75977968
83Dry hair (HP:0011359)1.75736366
84Abnormality of serum amino acid levels (HP:0003112)1.74858673
85Mask-like facies (HP:0000298)1.74801358
86Peritonitis (HP:0002586)1.74219396
87Abnormality of the vitamin B12 metabolism (HP:0004341)1.73902184
88Breast carcinoma (HP:0003002)1.72865496
89Exercise intolerance (HP:0003546)1.72170921
90Hip contracture (HP:0003273)1.71691561
91Tubulointerstitial nephritis (HP:0001970)1.70724299
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70504077
93Prostate neoplasm (HP:0100787)1.70296669
94Tinnitus (HP:0000360)1.66501425
95Leukodystrophy (HP:0002415)1.65424596
96Lethargy (HP:0001254)1.64814197
97Abnormality of magnesium homeostasis (HP:0004921)1.63189520
98Increased serum pyruvate (HP:0003542)1.62586307
99Nephronophthisis (HP:0000090)1.62457562
100Abnormality of glycolysis (HP:0004366)1.61691244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK35.31741525
2VRK24.24727884
3BRSK23.06729483
4CAMKK22.95808399
5GRK12.70236964
6MAPK132.51700785
7MST42.46236551
8PDK22.39823783
9PTK2B2.37953981
10BMPR1B2.30654830
11ZAK2.28803433
12TSSK62.24717797
13EIF2AK12.20234276
14VRK12.05880125
15EIF2AK21.83934743
16JAK31.77949484
17TAOK31.76312771
18NUAK11.74565373
19PBK1.74153806
20TRIM281.72142459
21NME11.69169658
22HIPK21.67236007
23TAF11.66266115
24ADRBK21.65284303
25TLK11.64839864
26OXSR11.63153096
27MKNK21.57023536
28CDK81.52209322
29PLK31.45979593
30MAP2K61.45401813
31STK391.40558500
32FRK1.39598464
33BUB11.35121531
34TXK1.34545237
35SRPK11.29900202
36STK38L1.29459990
37CAMKK11.23471890
38TEC1.20119098
39CSNK1G31.12727196
40WEE11.08919849
41NEK11.05999830
42BRSK11.05863510
43PKN21.01907646
44PLK21.00429510
45CSNK1G11.00196506
46PHKG20.99943299
47PHKG10.99943299
48TGFBR10.99765643
49CSNK1A1L0.97466325
50DAPK10.95352899
51WNK40.92467424
52MKNK10.92426538
53PAK30.92229154
54ITK0.91928184
55TNK20.86531592
56STK30.83337384
57PRKCI0.80003421
58MAPKAPK50.79553061
59BCKDK0.73086006
60DAPK20.72829942
61INSRR0.69909650
62TTK0.67947427
63ILK0.67860085
64CSNK1G20.66360683
65PRKCG0.62691827
66STK110.61406508
67WNK30.61204616
68TRPM70.60170725
69PAK40.59880176
70DYRK20.55140690
71STK240.53789384
72MAP3K90.53016034
73MAPKAPK30.52954809
74PLK10.52891506
75ALK0.52047383
76TNIK0.51331416
77MAP4K10.48946713
78WNK10.46936288
79CDC70.46321105
80RPS6KB10.45572901
81RPS6KB20.42704776
82ACVR1B0.36729556
83PRKCE0.36015338
84CSNK1A10.34770993
85CDK190.32190480
86PLK40.31623482
87STK160.30084278
88GRK50.29174145
89ATR0.28378372
90PINK10.27165618
91CSNK2A10.27107521
92SMG10.25517943
93CDK90.24119345
94NEK90.24073366
95IKBKB0.23861806
96TAOK10.22668252
97CSNK1E0.22386633
98FGFR10.22231780
99CSNK2A20.20914959
100MAP3K120.20825370

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.54613940
2Proteasome_Homo sapiens_hsa030504.38037790
3Asthma_Homo sapiens_hsa053103.36303646
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.94062044
5Allograft rejection_Homo sapiens_hsa053302.93812141
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81507319
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.71764706
8Autoimmune thyroid disease_Homo sapiens_hsa053202.52816522
9Protein export_Homo sapiens_hsa030602.37499312
10RNA degradation_Homo sapiens_hsa030182.20287404
11Basal transcription factors_Homo sapiens_hsa030222.10061272
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98460072
13Oxidative phosphorylation_Homo sapiens_hsa001901.89193613
14One carbon pool by folate_Homo sapiens_hsa006701.87811718
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85078310
16Primary immunodeficiency_Homo sapiens_hsa053401.76373244
17RNA polymerase_Homo sapiens_hsa030201.75975205
18Type I diabetes mellitus_Homo sapiens_hsa049401.71432811
19RNA transport_Homo sapiens_hsa030131.66290740
20Nitrogen metabolism_Homo sapiens_hsa009101.56639529
21Homologous recombination_Homo sapiens_hsa034401.53361141
22Parkinsons disease_Homo sapiens_hsa050121.52604175
23Propanoate metabolism_Homo sapiens_hsa006401.46672812
24Graft-versus-host disease_Homo sapiens_hsa053321.43342487
25Linoleic acid metabolism_Homo sapiens_hsa005911.42641046
26Mismatch repair_Homo sapiens_hsa034301.38624441
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35559691
28Ribosome_Homo sapiens_hsa030101.21375809
29Pentose phosphate pathway_Homo sapiens_hsa000301.18969150
30Selenocompound metabolism_Homo sapiens_hsa004501.18789740
31Sulfur metabolism_Homo sapiens_hsa009201.18260587
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18204691
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.17571292
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15206518
35Pyrimidine metabolism_Homo sapiens_hsa002401.14485181
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13149744
37Hematopoietic cell lineage_Homo sapiens_hsa046401.10854952
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08153188
39Steroid biosynthesis_Homo sapiens_hsa001001.05983065
40Huntingtons disease_Homo sapiens_hsa050161.04747031
41T cell receptor signaling pathway_Homo sapiens_hsa046601.03850978
42Nucleotide excision repair_Homo sapiens_hsa034201.00762731
43Regulation of autophagy_Homo sapiens_hsa041400.97532901
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95812111
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95778019
46Fanconi anemia pathway_Homo sapiens_hsa034600.93960297
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91007469
48Tryptophan metabolism_Homo sapiens_hsa003800.90239209
49DNA replication_Homo sapiens_hsa030300.87761299
50Caffeine metabolism_Homo sapiens_hsa002320.85072676
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84073226
52Alzheimers disease_Homo sapiens_hsa050100.82486271
53Rheumatoid arthritis_Homo sapiens_hsa053230.81522224
54Measles_Homo sapiens_hsa051620.76998827
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76403135
56Purine metabolism_Homo sapiens_hsa002300.74724471
57Base excision repair_Homo sapiens_hsa034100.74347221
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74237631
59Ether lipid metabolism_Homo sapiens_hsa005650.71156112
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71021616
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.68863694
62Mineral absorption_Homo sapiens_hsa049780.67857669
63Pyruvate metabolism_Homo sapiens_hsa006200.65057128
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64424585
65Arachidonic acid metabolism_Homo sapiens_hsa005900.59721568
66Antigen processing and presentation_Homo sapiens_hsa046120.58937170
67Peroxisome_Homo sapiens_hsa041460.56600703
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.55478526
69Non-homologous end-joining_Homo sapiens_hsa034500.55265726
70Butanoate metabolism_Homo sapiens_hsa006500.54470817
71Vitamin digestion and absorption_Homo sapiens_hsa049770.52692717
72Spliceosome_Homo sapiens_hsa030400.52692645
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52593344
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51106328
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50492393
76Carbon metabolism_Homo sapiens_hsa012000.50402030
77Metabolic pathways_Homo sapiens_hsa011000.49228829
78Phototransduction_Homo sapiens_hsa047440.44285260
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.43957116
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43615192
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42031634
82Ovarian steroidogenesis_Homo sapiens_hsa049130.39233557
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39088721
84Cardiac muscle contraction_Homo sapiens_hsa042600.36768364
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35189394
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34802485
87Herpes simplex infection_Homo sapiens_hsa051680.33992701
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33770877
89Biosynthesis of amino acids_Homo sapiens_hsa012300.33305108
90Retinol metabolism_Homo sapiens_hsa008300.31658547
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31446991
92Dorso-ventral axis formation_Homo sapiens_hsa043200.31053071
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30555914
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29183829
95Folate biosynthesis_Homo sapiens_hsa007900.27326870
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.26088243
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23180415
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23008950
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22234138
100Systemic lupus erythematosus_Homo sapiens_hsa053220.21339859

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