NPM1P49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle adaptation (GO:0043501)8.69466976
2striated muscle atrophy (GO:0014891)8.39921005
3protein K6-linked ubiquitination (GO:0085020)7.77630280
4skeletal muscle tissue regeneration (GO:0043403)7.52820886
5muscle atrophy (GO:0014889)7.29792584
6actin-myosin filament sliding (GO:0033275)7.16586822
7muscle filament sliding (GO:0030049)7.16586822
8response to muscle activity (GO:0014850)6.98869958
9negative regulation of muscle hypertrophy (GO:0014741)6.79314613
10regulation of skeletal muscle contraction (GO:0014819)6.76494945
11positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.95719866
12actin-mediated cell contraction (GO:0070252)5.94793677
13negative regulation of skeletal muscle tissue development (GO:0048642)5.46075821
14regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.09267711
15cellular response to dexamethasone stimulus (GO:0071549)4.95720054
16response to activity (GO:0014823)4.86488510
17response to dexamethasone (GO:0071548)4.57658839
18auditory receptor cell differentiation (GO:0042491)4.50135367
19actin filament-based movement (GO:0030048)4.19685818
20negative regulation of oligodendrocyte differentiation (GO:0048715)4.07212196
21positive regulation of action potential (GO:0045760)3.91595560
22positive regulation of histone H3-K4 methylation (GO:0051571)3.91321383
23cellular ketone body metabolic process (GO:0046950)3.75671788
24protein-cofactor linkage (GO:0018065)3.72739929
25regulation of regulatory T cell differentiation (GO:0045589)3.67385524
26positive regulation of cell cycle G1/S phase transition (GO:1902808)3.65241880
27negative regulation of cAMP-mediated signaling (GO:0043951)3.64515766
28ketone body metabolic process (GO:1902224)3.64288612
29regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.61875074
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.57866258
31negative regulation of translation, ncRNA-mediated (GO:0040033)3.57866258
32regulation of translation, ncRNA-mediated (GO:0045974)3.57866258
33striated muscle adaptation (GO:0014888)3.55836061
34regulation of acyl-CoA biosynthetic process (GO:0050812)3.55416855
35protein polyglutamylation (GO:0018095)3.46911642
36positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)3.46637365
37phosphorylated carbohydrate dephosphorylation (GO:0046838)3.44301578
38inositol phosphate dephosphorylation (GO:0046855)3.44301578
39inositol phosphate catabolic process (GO:0071545)3.41506642
40cullin deneddylation (GO:0010388)3.40538040
41neural tube formation (GO:0001841)3.33505862
42regulation of centriole replication (GO:0046599)3.25998956
43regulation of muscle hypertrophy (GO:0014743)3.20235551
44response to testosterone (GO:0033574)3.19908807
45regulation of relaxation of muscle (GO:1901077)3.18656141
46regulation of cofactor metabolic process (GO:0051193)3.15933285
47regulation of coenzyme metabolic process (GO:0051196)3.15933285
48protein deneddylation (GO:0000338)3.11768708
49myotube cell development (GO:0014904)3.08063137
50negative regulation of histone acetylation (GO:0035067)2.98194986
51muscle organ development (GO:0007517)2.97189559
52dendritic spine morphogenesis (GO:0060997)2.96807470
53muscle structure development (GO:0061061)2.95357109
54regulation of isotype switching to IgG isotypes (GO:0048302)2.92777240
55postsynaptic membrane organization (GO:0001941)2.90016168
56positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.89564436
57platelet dense granule organization (GO:0060155)2.88682406
58cellular response to glucocorticoid stimulus (GO:0071385)2.88204824
59regulation of sulfur metabolic process (GO:0042762)2.84978376
60negative regulation of fatty acid metabolic process (GO:0045922)2.82801614
61positive regulation of interleukin-17 production (GO:0032740)2.81532252
62regulation of glucokinase activity (GO:0033131)2.80533826
63regulation of hexokinase activity (GO:1903299)2.80533826
64tissue regeneration (GO:0042246)2.74110078
65negative regulation of organelle assembly (GO:1902116)2.73914757
66response to electrical stimulus (GO:0051602)2.65760274
67muscle adaptation (GO:0043500)2.63748393
68cellular response to corticosteroid stimulus (GO:0071384)2.61932388
69regulation of gene expression by genetic imprinting (GO:0006349)2.61699627
70protein trimerization (GO:0070206)2.61079763
71positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.58816724
72glycosphingolipid biosynthetic process (GO:0006688)2.58131040
73negative regulation of DNA-dependent DNA replication (GO:2000104)2.57688864
74forebrain neuron differentiation (GO:0021879)2.56703980
75negative regulation of fatty acid biosynthetic process (GO:0045717)2.56143022
76regulation of action potential (GO:0098900)2.55308934
77neuronal action potential propagation (GO:0019227)2.54753069
78skeletal muscle contraction (GO:0003009)2.53614783
79regulation of DNA methylation (GO:0044030)2.49166879
80Golgi to endosome transport (GO:0006895)2.49125834
81behavioral response to nicotine (GO:0035095)2.47271204
82axoneme assembly (GO:0035082)2.46329686
83heparin biosynthetic process (GO:0030210)2.43997196
84heparin metabolic process (GO:0030202)2.43997196
85genetic imprinting (GO:0071514)2.43373266
86hair cell differentiation (GO:0035315)2.43286865
87negative regulation of DNA recombination (GO:0045910)2.42844354
88negative regulation of peptidyl-lysine acetylation (GO:2000757)2.41937688
89regulation of oligodendrocyte differentiation (GO:0048713)2.41818520
90regulation of meiosis I (GO:0060631)2.41443447
91kynurenine metabolic process (GO:0070189)2.41408589
92regulation of transcription involved in cell fate commitment (GO:0060850)2.40180908
93positive regulation of dendritic spine development (GO:0060999)2.39322350
94nucleobase catabolic process (GO:0046113)2.39194368
95male sex determination (GO:0030238)2.38275764
96DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.36439759
97negative regulation of histone methylation (GO:0031061)2.34485680
98regulation of memory T cell differentiation (GO:0043380)2.33609317
99cAMP catabolic process (GO:0006198)2.32622073
100response to gravity (GO:0009629)12.1474577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human5.06607043
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.04067092
3TAF15_26573619_Chip-Seq_HEK293_Human4.62443884
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.80394789
5FUS_26573619_Chip-Seq_HEK293_Human3.02528483
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.91440305
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.81613310
8GBX2_23144817_ChIP-Seq_PC3_Human2.78239616
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.56813236
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.55950699
11ZNF274_21170338_ChIP-Seq_K562_Hela2.55034330
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54130661
13EZH2_22144423_ChIP-Seq_EOC_Human2.42563304
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.37698786
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33441264
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30384285
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20326426
18AR_21572438_ChIP-Seq_LNCaP_Human2.09560164
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08165260
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87692102
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86412419
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85349398
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82945040
24P300_19829295_ChIP-Seq_ESCs_Human1.77838796
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.74701038
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70232430
27ER_23166858_ChIP-Seq_MCF-7_Human1.70085604
28SMAD4_21799915_ChIP-Seq_A2780_Human1.65436799
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61676377
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57778177
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57469539
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.56647280
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56621457
34EWS_26573619_Chip-Seq_HEK293_Human1.55211500
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54774636
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52728270
37IGF1R_20145208_ChIP-Seq_DFB_Human1.52267501
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45693965
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.43864654
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43290380
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40169704
42STAT3_23295773_ChIP-Seq_U87_Human1.39724904
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38775257
44ELK1_19687146_ChIP-ChIP_HELA_Human1.36905126
45FLI1_21867929_ChIP-Seq_TH2_Mouse1.32705204
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32311963
47TP53_22573176_ChIP-Seq_HFKS_Human1.29438568
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29073931
49CBP_20019798_ChIP-Seq_JUKART_Human1.29073931
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28885996
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27279416
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24947741
53TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24454822
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.23223576
55P53_22387025_ChIP-Seq_ESCs_Mouse1.23165054
56SOX9_26525672_Chip-Seq_HEART_Mouse1.22766380
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22222736
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19504194
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19278793
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18156992
61IRF1_19129219_ChIP-ChIP_H3396_Human1.17835045
62KDM2B_26808549_Chip-Seq_REH_Human1.17356332
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17249051
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.16154705
65TCF4_23295773_ChIP-Seq_U87_Human1.15918105
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14847013
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14660221
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14523552
69VDR_23849224_ChIP-Seq_CD4+_Human1.13890505
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.13367739
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13064974
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12792586
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.10175784
74BCAT_22108803_ChIP-Seq_LS180_Human1.09740803
75P300_18555785_Chip-Seq_ESCs_Mouse1.09591841
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08278225
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06468297
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03998597
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.02765370
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.02417277
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02290916
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01976196
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01972605
84AR_25329375_ChIP-Seq_VCAP_Human1.01360904
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01292865
86GATA1_22025678_ChIP-Seq_K562_Human1.00222992
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.00220289
88CMYC_18555785_Chip-Seq_ESCs_Mouse0.99854767
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98796353
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97769154
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97445079
92MYC_19829295_ChIP-Seq_ESCs_Human0.96179016
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95824598
94OCT4_18555785_Chip-Seq_ESCs_Mouse0.94733851
95CTCF_18555785_Chip-Seq_ESCs_Mouse0.94609766
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.94016463
97RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93974993
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93872973
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.93803642
100NCOR_22424771_ChIP-Seq_293T_Human0.93291602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.63648231
2MP0004145_abnormal_muscle_electrophysio3.96458650
3MP0002938_white_spotting3.45008354
4MP0000747_muscle_weakness3.31891779
5MP0005083_abnormal_biliary_tract3.28988823
6MP0004270_analgesia3.23661885
7MP0004036_abnormal_muscle_relaxation2.97149040
8MP0000749_muscle_degeneration2.61244479
9MP0008877_abnormal_DNA_methylation2.55348547
10MP0005379_endocrine/exocrine_gland_phen2.37218137
11MP0002163_abnormal_gland_morphology2.35687927
12MP0002108_abnormal_muscle_morphology2.35632260
13MP0002269_muscular_atrophy2.26473335
14MP0000759_abnormal_skeletal_muscle2.18261165
15MP0002106_abnormal_muscle_physiology2.07483476
16MP0000566_synostosis2.05131161
17MP0005620_abnormal_muscle_contractility2.01298919
18MP0003787_abnormal_imprinting1.96889052
19MP0000049_abnormal_middle_ear1.96376184
20MP0002095_abnormal_skin_pigmentation1.92973730
21MP0003121_genomic_imprinting1.84179164
22MP0005174_abnormal_tail_pigmentation1.77702729
23MP0005369_muscle_phenotype1.73757731
24MP0009780_abnormal_chondrocyte_physiolo1.69321024
25MP0008789_abnormal_olfactory_epithelium1.67911108
26MP0006072_abnormal_retinal_apoptosis1.66098430
27MP0004885_abnormal_endolymph1.65169240
28MP0000750_abnormal_muscle_regeneration1.61948145
29MP0003786_premature_aging1.60922133
30MP0001984_abnormal_olfaction1.59018168
31MP0002089_abnormal_postnatal_growth/wei1.58308230
32MP0002837_dystrophic_cardiac_calcinosis1.56449986
33MP0003122_maternal_imprinting1.55792293
34MP0002102_abnormal_ear_morphology1.55219429
35MP0005646_abnormal_pituitary_gland1.54298616
36MP0006292_abnormal_olfactory_placode1.53979618
37MP0004087_abnormal_muscle_fiber1.52352872
38MP0003123_paternal_imprinting1.52224292
39MP0002638_abnormal_pupillary_reflex1.44376813
40MP0005248_abnormal_Harderian_gland1.37748437
41MP0000516_abnormal_urinary_system1.34248573
42MP0005367_renal/urinary_system_phenotyp1.34248573
43MP0002736_abnormal_nociception_after1.33314968
44MP0003755_abnormal_palate_morphology1.24582359
45MP0001270_distended_abdomen1.24472890
46MP0003938_abnormal_ear_development1.22536466
47MP0003937_abnormal_limbs/digits/tail_de1.22151915
48MP0004484_altered_response_of1.16878260
49MP0005645_abnormal_hypothalamus_physiol1.15650991
50MP0010307_abnormal_tumor_latency1.13438645
51MP0002254_reproductive_system_inflammat1.13353966
52MP0001968_abnormal_touch/_nociception1.13305256
53MP0008995_early_reproductive_senescence1.10903938
54MP0000427_abnormal_hair_cycle1.08553972
55MP0005253_abnormal_eye_physiology1.08447750
56MP0001963_abnormal_hearing_physiology1.07890573
57MP0000751_myopathy1.06567415
58MP0002896_abnormal_bone_mineralization1.05623130
59MP0005551_abnormal_eye_electrophysiolog1.02536092
60MP0002277_abnormal_respiratory_mucosa1.00409040
61MP0001346_abnormal_lacrimal_gland0.99382797
62MP0000733_abnormal_muscle_development0.98015239
63MP0000013_abnormal_adipose_tissue0.96902283
64MP0003959_abnormal_lean_body0.96628533
65MP0004215_abnormal_myocardial_fiber0.96124433
66MP0004142_abnormal_muscle_tone0.90618158
67MP0003646_muscle_fatigue0.87182336
68MP0001502_abnormal_circadian_rhythm0.85461739
69MP0003195_calcinosis0.85318308
70MP0004084_abnormal_cardiac_muscle0.84453818
71MP0002751_abnormal_autonomic_nervous0.83942138
72MP0004043_abnormal_pH_regulation0.82949245
73MP0000465_gastrointestinal_hemorrhage0.82078897
74MP0005499_abnormal_olfactory_system0.81556866
75MP0005394_taste/olfaction_phenotype0.81556866
76MP0000631_abnormal_neuroendocrine_gland0.80847407
77MP0009745_abnormal_behavioral_response0.79632201
78MP0003950_abnormal_plasma_membrane0.78956527
79MP0002734_abnormal_mechanical_nocicepti0.78133257
80MP0003880_abnormal_central_pattern0.77386504
81MP0002282_abnormal_trachea_morphology0.72553808
82MP0001486_abnormal_startle_reflex0.71218249
83MP0003045_fibrosis0.71131409
84MP0005171_absent_coat_pigmentation0.71042105
85MP0002557_abnormal_social/conspecific_i0.70813687
86MP0006276_abnormal_autonomic_nervous0.69973464
87MP0002928_abnormal_bile_duct0.69906225
88MP0005647_abnormal_sex_gland0.69352066
89MP0009046_muscle_twitch0.68692294
90MP0000639_abnormal_adrenal_gland0.68127913
91MP0002075_abnormal_coat/hair_pigmentati0.64646593
92MP0002233_abnormal_nose_morphology0.64645634
93MP0001501_abnormal_sleep_pattern0.63837369
94MP0000604_amyloidosis0.63669245
95MP0001661_extended_life_span0.63594147
96MP0004197_abnormal_fetal_growth/weight/0.62227649
97MP0002115_abnormal_skeleton_extremities0.60745430
98MP0000026_abnormal_inner_ear0.60224240
99MP0002184_abnormal_innervation0.59542552
100MP0002876_abnormal_thyroid_physiology0.58531143

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)7.53441846
2Nemaline bodies (HP:0003798)5.65452725
3Distal arthrogryposis (HP:0005684)5.30358648
4Mask-like facies (HP:0000298)4.67972991
5Round ear (HP:0100830)4.61624224
6Muscle fiber inclusion bodies (HP:0100299)4.45703026
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.42594863
8Exercise-induced myalgia (HP:0003738)4.37757741
9Absent phalangeal crease (HP:0006109)4.26649022
10Calcaneovalgus deformity (HP:0001848)3.77047325
11Ulnar deviation of the wrist (HP:0003049)3.71798361
12Facial edema (HP:0000282)3.70767461
13Abnormal finger flexion creases (HP:0006143)3.69397264
14Periorbital edema (HP:0100539)3.69180694
153-Methylglutaconic aciduria (HP:0003535)3.46564461
16Hyperkalemia (HP:0002153)3.32318910
17Deformed tarsal bones (HP:0008119)3.27674485
18Neoplasm of the heart (HP:0100544)3.07437347
19Fibular aplasia (HP:0002990)2.98993810
20Difficulty running (HP:0009046)2.85373875
21Neoplasm of the adrenal cortex (HP:0100641)2.77589681
22Exercise-induced muscle cramps (HP:0003710)2.76230540
23Type 1 muscle fiber predominance (HP:0003803)2.64352669
24Renal dysplasia (HP:0000110)2.61429025
25Hepatoblastoma (HP:0002884)2.49566307
26Nephronophthisis (HP:0000090)2.48743613
27Oligodactyly (hands) (HP:0001180)2.47456061
28Pancreatic fibrosis (HP:0100732)2.45703912
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40749494
30Congenital stationary night blindness (HP:0007642)2.38519316
31Metaphyseal dysplasia (HP:0100255)2.38363603
32Muscle hypertrophy of the lower extremities (HP:0008968)2.37817741
33Decreased circulating renin level (HP:0003351)2.37750276
34Volvulus (HP:0002580)2.37415570
35Delayed CNS myelination (HP:0002188)2.33489305
36Pancreatic cysts (HP:0001737)2.31190551
37True hermaphroditism (HP:0010459)2.28169102
38Adrenal hypoplasia (HP:0000835)2.27891409
39Nonprogressive disorder (HP:0003680)2.24809570
40Menstrual irregularities (HP:0000858)2.22993674
41Pendular nystagmus (HP:0012043)2.22572147
42Abnormal rod and cone electroretinograms (HP:0008323)2.17494967
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15884457
44Intestinal atresia (HP:0011100)2.13946284
45Absent speech (HP:0001344)2.08268690
46Type II lissencephaly (HP:0007260)2.07662284
47Poor speech (HP:0002465)2.06743563
48Keratoconus (HP:0000563)2.05774898
49Increased corneal curvature (HP:0100692)2.05774898
50Myotonia (HP:0002486)2.04097812
51Recurrent corneal erosions (HP:0000495)2.01749804
52Chronic hepatic failure (HP:0100626)2.00738041
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00093210
54Metatarsus adductus (HP:0001840)1.99374163
55Aqueductal stenosis (HP:0002410)1.98129309
562-3 toe syndactyly (HP:0004691)1.97813251
57Attenuation of retinal blood vessels (HP:0007843)1.97636916
58Oligodactyly (HP:0012165)1.96812309
59Parakeratosis (HP:0001036)1.90807925
60Abnormality of potassium homeostasis (HP:0011042)1.89698910
61Abnormality of the renal medulla (HP:0100957)1.89495569
62Aplasia/Hypoplasia of the fovea (HP:0008060)1.89249569
63Hypoplasia of the fovea (HP:0007750)1.89249569
64Hypoplastic ischia (HP:0003175)1.88447140
65Abolished electroretinogram (ERG) (HP:0000550)1.88439735
66Diastasis recti (HP:0001540)1.87871247
67Cerebellar dysplasia (HP:0007033)1.86860572
68Breast carcinoma (HP:0003002)1.85500695
69Action tremor (HP:0002345)1.85448552
70Gonadotropin excess (HP:0000837)1.82604028
71Cortical dysplasia (HP:0002539)1.82458513
72Alopecia of scalp (HP:0002293)1.81830221
73Myopathic facies (HP:0002058)1.80906383
74Gout (HP:0001997)1.80068745
75Drooling (HP:0002307)1.79607674
76Polydipsia (HP:0001959)1.79054380
77Abnormal drinking behavior (HP:0030082)1.79054380
78Chorioretinal atrophy (HP:0000533)1.78759808
79Hypoplastic iliac wings (HP:0002866)1.75398352
80Abnormality of the renal cortex (HP:0011035)1.74487499
81Depressed nasal tip (HP:0000437)1.73986935
82Pachygyria (HP:0001302)1.73854602
83Abnormality of the labia minora (HP:0012880)1.72530594
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72193867
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.69505166
86Increased purine levels (HP:0004368)1.69318572
87Hyperuricemia (HP:0002149)1.69318572
88Myoglobinuria (HP:0002913)1.69226787
89Abnormality of the calf musculature (HP:0001430)1.69045280
90Macroorchidism (HP:0000053)1.67667367
91Abnormality of the ischium (HP:0003174)1.66793312
92Short phalanx of the thumb (HP:0009660)1.66763620
93Down-sloping shoulders (HP:0200021)1.66394219
94Steppage gait (HP:0003376)1.66073395
95Abnormality of the proximal phalanges of the hand (HP:0009834)1.63257480
96Growth hormone deficiency (HP:0000824)1.63224447
97Widely spaced teeth (HP:0000687)1.63090440
98Blue irides (HP:0000635)1.61517354
99Neoplasm of the adrenal gland (HP:0100631)1.60831069
100Excessive salivation (HP:0003781)1.60465516

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.43389899
2BRD43.94966616
3PHKG23.59379585
4PHKG13.59379585
5NEK13.57981536
6TIE12.90487122
7OBSCN2.83541652
8WNK42.64403944
9MAP3K42.58969222
10MAPK132.55181091
11NUAK12.32132026
12WNK32.18788268
13FGFR22.08999335
14PRKD31.97745675
15EIF2AK31.97465047
16CDK191.97213918
17MST41.83227003
18CCNB11.78287708
19CASK1.64413834
20DAPK21.63424602
21PLK21.62129943
22IRAK11.53358891
23CDC71.47560850
24MAP4K21.42596168
25IRAK41.36763736
26LIMK11.28745247
27ADRBK21.28322468
28PINK11.28090866
29WNK11.27776316
30PLK31.24082305
31RPS6KA41.13991867
32GRK51.12288164
33SRPK11.11641707
34GRK11.10728358
35SCYL21.10703951
36CAMKK21.08825017
37VRK21.07667649
38MAP2K71.05377330
39ZAK1.00436761
40TAF11.00412462
41ERBB30.95765398
42EIF2AK10.95589902
43EIF2AK20.92357590
44PRKCE0.92299259
45CHEK20.85152762
46TEC0.84417105
47CAMK2G0.83432099
48CSNK1A1L0.77266505
49DYRK20.71093127
50TYRO30.69616155
51BUB10.68775671
52DAPK10.64301558
53PIK3CA0.64126564
54CSNK1G10.63934393
55PLK10.63788054
56MARK10.63039965
57BCKDK0.59985288
58PLK40.59834391
59CSNK1G30.58336558
60TXK0.57906843
61CSNK1G20.57244583
62ATR0.57066381
63PRKD20.56696721
64VRK10.55858685
65RPS6KA50.53517503
66ATM0.51751681
67STK390.50824409
68TRPM70.50739669
69PKN10.50433548
70TAOK10.49741810
71MINK10.48319591
72MARK30.47580587
73PIK3CG0.47365219
74MAPK70.46545606
75CAMK1D0.45672750
76PRKG10.44162955
77DYRK1B0.43687341
78PRKACA0.43047307
79FGFR30.41728599
80CAMK40.40751692
81AURKA0.36175942
82DYRK1A0.35551195
83BCR0.34644743
84PRKACB0.32189216
85DMPK0.31592202
86CAMK2D0.31502967
87NTRK20.31399658
88CAMK2A0.29979326
89SGK10.29006892
90AURKB0.28086960
91BMPR1B0.27268185
92CAMK10.26569959
93ICK0.25799264
94EGFR0.25135572
95ROCK10.24268121
96CDK40.23565136
97INSRR0.22309854
98PTK2B0.21933317
99PRKCG0.21379260
100TRIM280.20810969

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.02046414
2Tight junction_Homo sapiens_hsa045303.16143323
3Butanoate metabolism_Homo sapiens_hsa006502.84406423
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.54531209
5Phototransduction_Homo sapiens_hsa047442.31871447
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.23862453
7Circadian rhythm_Homo sapiens_hsa047102.16618960
8Regulation of autophagy_Homo sapiens_hsa041402.02519858
9Peroxisome_Homo sapiens_hsa041461.92025534
10Ether lipid metabolism_Homo sapiens_hsa005651.90748253
11Circadian entrainment_Homo sapiens_hsa047131.86870690
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78230753
13Insulin secretion_Homo sapiens_hsa049111.77800712
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.77703888
15Linoleic acid metabolism_Homo sapiens_hsa005911.76520619
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72416332
17Calcium signaling pathway_Homo sapiens_hsa040201.67475637
18Morphine addiction_Homo sapiens_hsa050321.66347158
19Protein export_Homo sapiens_hsa030601.61327713
20Hedgehog signaling pathway_Homo sapiens_hsa043401.61263441
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56331497
22Nitrogen metabolism_Homo sapiens_hsa009101.56194578
23Cardiac muscle contraction_Homo sapiens_hsa042601.53230620
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.42830004
25Homologous recombination_Homo sapiens_hsa034401.42759119
26Basal transcription factors_Homo sapiens_hsa030221.41680763
27GABAergic synapse_Homo sapiens_hsa047271.41409702
28Renin secretion_Homo sapiens_hsa049241.37063968
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32537586
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28316406
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26778525
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25912477
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23962011
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22144016
35Nicotine addiction_Homo sapiens_hsa050331.21396172
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20575770
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20377895
38Oxytocin signaling pathway_Homo sapiens_hsa049211.18773200
39Dilated cardiomyopathy_Homo sapiens_hsa054141.13363568
40Type I diabetes mellitus_Homo sapiens_hsa049401.12310730
41Fanconi anemia pathway_Homo sapiens_hsa034601.12069423
42Oocyte meiosis_Homo sapiens_hsa041141.10636043
43Olfactory transduction_Homo sapiens_hsa047401.09150313
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08294951
45Arginine biosynthesis_Homo sapiens_hsa002201.06011839
46RNA degradation_Homo sapiens_hsa030180.99818120
47RNA polymerase_Homo sapiens_hsa030200.98915136
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98591289
49Proteasome_Homo sapiens_hsa030500.98283468
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95932631
51Oxidative phosphorylation_Homo sapiens_hsa001900.95203876
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.93873641
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90048505
54Gastric acid secretion_Homo sapiens_hsa049710.89769598
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89288737
56Dopaminergic synapse_Homo sapiens_hsa047280.89147907
57Spliceosome_Homo sapiens_hsa030400.88269989
58Parkinsons disease_Homo sapiens_hsa050120.87642873
59Salivary secretion_Homo sapiens_hsa049700.86666278
60Purine metabolism_Homo sapiens_hsa002300.85516440
61Taste transduction_Homo sapiens_hsa047420.84911975
62Glucagon signaling pathway_Homo sapiens_hsa049220.81985535
63Alzheimers disease_Homo sapiens_hsa050100.79633908
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77129016
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74717574
66Amphetamine addiction_Homo sapiens_hsa050310.71730167
67Fatty acid biosynthesis_Homo sapiens_hsa000610.70883411
68Long-term depression_Homo sapiens_hsa047300.69854723
69Serotonergic synapse_Homo sapiens_hsa047260.65790832
70cAMP signaling pathway_Homo sapiens_hsa040240.65627403
71Glutamatergic synapse_Homo sapiens_hsa047240.62455478
72Propanoate metabolism_Homo sapiens_hsa006400.59081508
73Tryptophan metabolism_Homo sapiens_hsa003800.58798987
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54833708
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51302306
76Ovarian steroidogenesis_Homo sapiens_hsa049130.50312774
77RNA transport_Homo sapiens_hsa030130.47874435
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47782953
79Pyruvate metabolism_Homo sapiens_hsa006200.46999515
80Fatty acid metabolism_Homo sapiens_hsa012120.46926334
81AMPK signaling pathway_Homo sapiens_hsa041520.46536733
82Alcoholism_Homo sapiens_hsa050340.43738877
83Caffeine metabolism_Homo sapiens_hsa002320.42365336
84TGF-beta signaling pathway_Homo sapiens_hsa043500.42136476
85Pancreatic secretion_Homo sapiens_hsa049720.41465698
86Wnt signaling pathway_Homo sapiens_hsa043100.41086817
87mRNA surveillance pathway_Homo sapiens_hsa030150.39028538
88Asthma_Homo sapiens_hsa053100.38496126
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37685268
90Chemical carcinogenesis_Homo sapiens_hsa052040.37502827
91Huntingtons disease_Homo sapiens_hsa050160.37329048
92Cholinergic synapse_Homo sapiens_hsa047250.33694819
93Collecting duct acid secretion_Homo sapiens_hsa049660.33399255
94Arachidonic acid metabolism_Homo sapiens_hsa005900.33140608
95Basal cell carcinoma_Homo sapiens_hsa052170.32115846
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30097316
97Fat digestion and absorption_Homo sapiens_hsa049750.28776474
98Systemic lupus erythematosus_Homo sapiens_hsa053220.27775455
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27556260
100Retinol metabolism_Homo sapiens_hsa008300.27396576

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