NPM1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.64045728
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.83473657
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.82370457
4DNA deamination (GO:0045006)4.72499190
5rRNA modification (GO:0000154)4.70777942
6ATP synthesis coupled proton transport (GO:0015986)4.56911576
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.56911576
8chaperone-mediated protein transport (GO:0072321)4.28262557
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.21840016
10protein neddylation (GO:0045116)4.15102105
11rRNA methylation (GO:0031167)4.13052034
12nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.06100912
13exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.05659700
14regulation of cellular amino acid metabolic process (GO:0006521)3.96276304
15ribosome assembly (GO:0042255)3.86964163
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.83215642
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.83215642
18NADH dehydrogenase complex assembly (GO:0010257)3.83215642
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82599221
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.82157735
21chromatin remodeling at centromere (GO:0031055)3.80423899
22folic acid-containing compound biosynthetic process (GO:0009396)3.79102404
23CENP-A containing nucleosome assembly (GO:0034080)3.75799709
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.75595782
25negative regulation of ligase activity (GO:0051352)3.75595782
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.75438931
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.75438931
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.72719649
29water-soluble vitamin biosynthetic process (GO:0042364)3.71669625
30protein complex biogenesis (GO:0070271)3.69825101
31signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.69034963
32signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.69034963
33signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.69034963
34pseudouridine synthesis (GO:0001522)3.67340030
35mitochondrial respiratory chain complex assembly (GO:0033108)3.66061803
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.65583825
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.65583825
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.58620551
39somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.58308062
40somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.58308062
41isotype switching (GO:0045190)3.58308062
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55053433
43regulation of chronic inflammatory response (GO:0002676)3.53050820
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.51978968
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.51978968
46positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.50124450
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.46757050
48IMP biosynthetic process (GO:0006188)3.46622087
49ribosomal large subunit biogenesis (GO:0042273)3.40569720
50DNA double-strand break processing (GO:0000729)3.35451222
51rRNA processing (GO:0006364)3.33546740
52termination of RNA polymerase III transcription (GO:0006386)3.27608652
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.27608652
54spliceosomal snRNP assembly (GO:0000387)3.26646957
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25978910
56rRNA metabolic process (GO:0016072)3.23587176
57viral mRNA export from host cell nucleus (GO:0046784)3.20123607
58protein-cofactor linkage (GO:0018065)3.19053364
59maturation of 5.8S rRNA (GO:0000460)3.18152756
60respiratory electron transport chain (GO:0022904)3.17982772
61DNA catabolic process, exonucleolytic (GO:0000738)3.17809016
62histone exchange (GO:0043486)3.17052200
63electron transport chain (GO:0022900)3.16219692
64positive regulation of ligase activity (GO:0051351)3.14873789
65regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.14641375
66protein targeting to mitochondrion (GO:0006626)3.13793395
67IMP metabolic process (GO:0046040)3.13643114
68respiratory chain complex IV assembly (GO:0008535)3.12878883
69cullin deneddylation (GO:0010388)3.12332533
70regulation of isotype switching to IgG isotypes (GO:0048302)3.09345782
71maturation of SSU-rRNA (GO:0030490)3.07938438
72pteridine-containing compound biosynthetic process (GO:0042559)3.01693858
73GTP biosynthetic process (GO:0006183)3.01021672
74ribosome biogenesis (GO:0042254)3.00895530
75termination of RNA polymerase I transcription (GO:0006363)3.00519490
76purine nucleobase biosynthetic process (GO:0009113)3.00296150
77inner mitochondrial membrane organization (GO:0007007)2.99852679
78tRNA processing (GO:0008033)2.99564771
79transcription elongation from RNA polymerase I promoter (GO:0006362)2.97905948
80protein localization to mitochondrion (GO:0070585)2.95470305
81translation (GO:0006412)2.94668355
82cellular component biogenesis (GO:0044085)2.90712467
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89959162
84ribosomal small subunit assembly (GO:0000028)2.89770169
85nucleobase biosynthetic process (GO:0046112)2.89492302
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89145325
87regulation of immunoglobulin secretion (GO:0051023)2.88989289
88DNA replication checkpoint (GO:0000076)2.88705744
89establishment of protein localization to mitochondrion (GO:0072655)2.88433036
90tRNA metabolic process (GO:0006399)2.88124846
91purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85193382
92intracellular protein transmembrane import (GO:0044743)2.84856137
93histone mRNA metabolic process (GO:0008334)2.84333785
94regulation of ubiquitin-protein transferase activity (GO:0051438)2.84082387
95DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.84031935
96formation of translation preinitiation complex (GO:0001731)2.83971070
97regulation of cellular amine metabolic process (GO:0033238)2.83938140
98mitochondrial RNA metabolic process (GO:0000959)2.83366093
99ncRNA metabolic process (GO:0034660)2.83242022
100protein deneddylation (GO:0000338)2.80109972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.30915002
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.97869801
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.66714431
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.36719607
5E2F7_22180533_ChIP-Seq_HELA_Human3.33186096
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.26319044
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17803949
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09510117
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.96905693
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95240481
11VDR_23849224_ChIP-Seq_CD4+_Human2.80072408
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67317229
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65237696
14ELK1_19687146_ChIP-ChIP_HELA_Human2.63171094
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62404607
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62124060
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62116315
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53934487
19FOXP3_21729870_ChIP-Seq_TREG_Human2.40585249
20VDR_22108803_ChIP-Seq_LS180_Human2.28099565
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15253870
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05553814
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.02026367
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01050633
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98354853
26EWS_26573619_Chip-Seq_HEK293_Human1.91438623
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89860013
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88808111
29ZNF274_21170338_ChIP-Seq_K562_Hela1.87381638
30DCP1A_22483619_ChIP-Seq_HELA_Human1.80071538
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.79015320
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76898282
33TTF2_22483619_ChIP-Seq_HELA_Human1.74284287
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67502625
35MYC_18940864_ChIP-ChIP_HL60_Human1.64748872
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.63290549
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59097431
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58139710
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56369953
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56181027
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54726400
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54257564
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.53024953
44GABP_19822575_ChIP-Seq_HepG2_Human1.49869728
45TAF15_26573619_Chip-Seq_HEK293_Human1.47167785
46FUS_26573619_Chip-Seq_HEK293_Human1.46927941
47XRN2_22483619_ChIP-Seq_HELA_Human1.45852641
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43295716
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35607965
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35606269
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34794629
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30800607
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27864347
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25690919
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24117413
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24060862
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24004674
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.21406133
59TP53_22573176_ChIP-Seq_HFKS_Human1.21225671
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20666560
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20383338
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17612560
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16816502
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15694704
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.11353237
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08921557
67P300_19829295_ChIP-Seq_ESCs_Human1.07760434
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05924795
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.03073072
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03073072
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02613127
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00425258
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00343893
74NANOG_19829295_ChIP-Seq_ESCs_Human0.99923792
75SOX2_19829295_ChIP-Seq_ESCs_Human0.99923792
76NFE2_27457419_Chip-Seq_LIVER_Mouse0.99095048
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97715980
78IGF1R_20145208_ChIP-Seq_DFB_Human0.96224753
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95258959
80SALL1_21062744_ChIP-ChIP_HESCs_Human0.95128784
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94574372
82FOXM1_23109430_ChIP-Seq_U2OS_Human0.94158946
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93156571
84NANOG_16153702_ChIP-ChIP_HESCs_Human0.92086242
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91984966
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88530715
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.87360336
88AR_21909140_ChIP-Seq_LNCAP_Human0.87237552
89ERG_20517297_ChIP-Seq_VCAP_Human0.84486603
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82778836
91IRF1_19129219_ChIP-ChIP_H3396_Human0.82455656
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82296619
93AR_20517297_ChIP-Seq_VCAP_Human0.81181165
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80832566
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80643972
96GATA3_26560356_Chip-Seq_TH2_Human0.80566646
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79023341
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76571354
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.76451856
100ER_23166858_ChIP-Seq_MCF-7_Human0.76147991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.12113113
2MP0002102_abnormal_ear_morphology3.07824212
3MP0008058_abnormal_DNA_repair3.03344598
4MP0004957_abnormal_blastocyst_morpholog2.93030835
5MP0003693_abnormal_embryo_hatching2.87208279
6MP0006292_abnormal_olfactory_placode2.63585923
7MP0005084_abnormal_gallbladder_morpholo2.56557852
8MP0001835_abnormal_antigen_presentation2.56153945
9MP0008877_abnormal_DNA_methylation2.53821030
10MP0008057_abnormal_DNA_replication2.51058799
11MP0003718_maternal_effect2.49872655
12MP0008872_abnormal_physiological_respon2.42929905
13MP0003806_abnormal_nucleotide_metabolis2.39582367
14MP0004147_increased_porphyrin_level2.34172898
15MP0008875_abnormal_xenobiotic_pharmacok2.08455206
16MP0003786_premature_aging2.07881295
17MP0006072_abnormal_retinal_apoptosis2.02570267
18MP0005671_abnormal_response_to1.94823770
19MP0003077_abnormal_cell_cycle1.86375871
20MP0002736_abnormal_nociception_after1.85712130
21MP0003111_abnormal_nucleus_morphology1.74979968
22MP0006036_abnormal_mitochondrial_physio1.74094972
23MP0001873_stomach_inflammation1.73020408
24MP0002938_white_spotting1.72611682
25MP0006035_abnormal_mitochondrial_morpho1.64395414
26MP0001293_anophthalmia1.62986369
27MP0003567_abnormal_fetal_cardiomyocyte1.61545942
28MP0008995_early_reproductive_senescence1.57696387
29MP0003186_abnormal_redox_activity1.57523332
30MP0009333_abnormal_splenocyte_physiolog1.53882930
31MP0002138_abnormal_hepatobiliary_system1.53832398
32MP0000372_irregular_coat_pigmentation1.50269096
33MP0000685_abnormal_immune_system1.49749009
34MP0001968_abnormal_touch/_nociception1.45931835
35MP0009697_abnormal_copulation1.45667978
36MP0002006_tumorigenesis1.45610039
37MP0009379_abnormal_foot_pigmentation1.41422144
38MP0003195_calcinosis1.38127648
39MP0002277_abnormal_respiratory_mucosa1.37509631
40MP0005646_abnormal_pituitary_gland1.35930073
41MP0005551_abnormal_eye_electrophysiolog1.32471354
42MP0001764_abnormal_homeostasis1.28327779
43MP0003890_abnormal_embryonic-extraembry1.27469045
44MP0002160_abnormal_reproductive_system1.19016529
45MP0004145_abnormal_muscle_electrophysio1.16930791
46MP0003787_abnormal_imprinting1.14613098
47MP0002148_abnormal_hypersensitivity_rea1.13779814
48MP0008932_abnormal_embryonic_tissue1.11243696
49MP0008007_abnormal_cellular_replicative1.10546536
50MP0001501_abnormal_sleep_pattern1.09680584
51MP0000647_abnormal_sebaceous_gland1.07852199
52MP0001790_abnormal_immune_system1.07523037
53MP0005387_immune_system_phenotype1.07523037
54MP0002234_abnormal_pharynx_morphology1.07448647
55MP0005253_abnormal_eye_physiology1.07403210
56MP0001529_abnormal_vocalization1.03652423
57MP0004782_abnormal_surfactant_physiolog1.03620850
58MP0004885_abnormal_endolymph1.01997462
59MP0010386_abnormal_urinary_bladder1.01683399
60MP0002166_altered_tumor_susceptibility1.01516723
61MP0003646_muscle_fatigue1.01369331
62MP0002837_dystrophic_cardiac_calcinosis0.99748412
63MP0005389_reproductive_system_phenotype0.99674349
64MP0009785_altered_susceptibility_to0.99108341
65MP0004133_heterotaxia0.98957084
66MP0005636_abnormal_mineral_homeostasis0.98789049
67MP0001485_abnormal_pinna_reflex0.97547472
68MP0005075_abnormal_melanosome_morpholog0.95327830
69MP0001984_abnormal_olfaction0.95123652
70MP0002210_abnormal_sex_determination0.95098277
71MP0001800_abnormal_humoral_immune0.94062701
72MP0005085_abnormal_gallbladder_physiolo0.93682532
73MP0005645_abnormal_hypothalamus_physiol0.93309812
74MP0002163_abnormal_gland_morphology0.92457729
75MP0008789_abnormal_olfactory_epithelium0.86543262
76MP0009764_decreased_sensitivity_to0.85475062
77MP0001929_abnormal_gametogenesis0.85000008
78MP0001119_abnormal_female_reproductive0.82748417
79MP0001853_heart_inflammation0.81584252
80MP0001881_abnormal_mammary_gland0.80458360
81MP0005395_other_phenotype0.80241334
82MP0001919_abnormal_reproductive_system0.79784252
83MP0000653_abnormal_sex_gland0.78157863
84MP0005332_abnormal_amino_acid0.74386107
85MP0000689_abnormal_spleen_morphology0.74031270
86MP0003011_delayed_dark_adaptation0.73783639
87MP0003119_abnormal_digestive_system0.73388515
88MP0001986_abnormal_taste_sensitivity0.73221996
89MP0006276_abnormal_autonomic_nervous0.72315526
90MP0005408_hypopigmentation0.71262955
91MP0005379_endocrine/exocrine_gland_phen0.70851642
92MP0005377_hearing/vestibular/ear_phenot0.70379773
93MP0003878_abnormal_ear_physiology0.70379773
94MP0001145_abnormal_male_reproductive0.69861861
95MP0001188_hyperpigmentation0.69490133
96MP0002019_abnormal_tumor_incidence0.69453979
97MP0005410_abnormal_fertilization0.69361733
98MP0008873_increased_physiological_sensi0.69161564
99MP0004142_abnormal_muscle_tone0.68584052
100MP0003936_abnormal_reproductive_system0.68529490

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.72408024
2Acute encephalopathy (HP:0006846)4.25263726
3Increased CSF lactate (HP:0002490)4.16418344
4Mitochondrial inheritance (HP:0001427)4.11674710
5Increased hepatocellular lipid droplets (HP:0006565)4.11619035
6Abnormal mitochondria in muscle tissue (HP:0008316)4.06661884
7Progressive macrocephaly (HP:0004481)3.91052505
8Lipid accumulation in hepatocytes (HP:0006561)3.83233408
9Colon cancer (HP:0003003)3.34269502
10Stomatitis (HP:0010280)3.25824897
11Hepatocellular necrosis (HP:0001404)3.17050705
12Cerebral edema (HP:0002181)3.10974932
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.08117175
14Increased serum lactate (HP:0002151)3.06941263
15Abnormality of the labia minora (HP:0012880)2.98812249
16Methylmalonic acidemia (HP:0002912)2.94337555
17Abnormality of aspartate family amino acid metabolism (HP:0010899)2.89508083
18Renal Fanconi syndrome (HP:0001994)2.89422641
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88926307
20Abnormality of alanine metabolism (HP:0010916)2.88926307
21Hyperalaninemia (HP:0003348)2.88926307
22Hepatic necrosis (HP:0002605)2.83734867
23Exertional dyspnea (HP:0002875)2.79885708
24Increased serum pyruvate (HP:0003542)2.79100843
25Abnormality of methionine metabolism (HP:0010901)2.74569516
26Abnormality of the pons (HP:0007361)2.70992429
27Abnormality of serum amino acid levels (HP:0003112)2.70351749
28Pancreatic cysts (HP:0001737)2.62360272
29Optic disc pallor (HP:0000543)2.60746181
30Aplastic anemia (HP:0001915)2.60662214
31Congenital, generalized hypertrichosis (HP:0004540)2.58119068
32IgG deficiency (HP:0004315)2.56106303
33Supernumerary spleens (HP:0009799)2.52055780
34Lactic acidosis (HP:0003128)2.50649678
35Constricted visual fields (HP:0001133)2.50499135
36Hyperglycinemia (HP:0002154)2.50194078
37Abnormal number of erythroid precursors (HP:0012131)2.43633374
38Multiple enchondromatosis (HP:0005701)2.41191473
39Increased intramyocellular lipid droplets (HP:0012240)2.40464975
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38581022
41Exercise intolerance (HP:0003546)2.38288569
42Abnormality of glycolysis (HP:0004366)2.36821923
43Lethargy (HP:0001254)2.36299603
44Volvulus (HP:0002580)2.34567316
45Methylmalonic aciduria (HP:0012120)2.33357557
46Leukodystrophy (HP:0002415)2.32842172
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32752873
48Pendular nystagmus (HP:0012043)2.32619549
49Abnormality of the ileum (HP:0001549)2.30127555
503-Methylglutaconic aciduria (HP:0003535)2.27098688
51Meckel diverticulum (HP:0002245)2.23562320
52Hypoplasia of the pons (HP:0012110)2.22834089
53Respiratory failure (HP:0002878)2.21640121
54Respiratory difficulties (HP:0002880)2.16446093
55Cerebral hypomyelination (HP:0006808)2.16239366
56Abnormality of cells of the erythroid lineage (HP:0012130)2.15472809
57True hermaphroditism (HP:0010459)2.15277655
58Duplicated collecting system (HP:0000081)2.14807868
59Pancreatic fibrosis (HP:0100732)2.13898611
60Macrocytic anemia (HP:0001972)2.08653204
61Pancytopenia (HP:0001876)2.07174840
62Premature ovarian failure (HP:0008209)2.04751228
63Abnormality of midbrain morphology (HP:0002418)2.02083053
64Molar tooth sign on MRI (HP:0002419)2.02083053
65Large for gestational age (HP:0001520)2.01725808
66Abolished electroretinogram (ERG) (HP:0000550)2.01591651
67Carpal bone hypoplasia (HP:0001498)1.99103872
68Reticulocytopenia (HP:0001896)1.98886772
69Oral leukoplakia (HP:0002745)1.98306363
70Glycosuria (HP:0003076)1.98040788
71Abnormality of urine glucose concentration (HP:0011016)1.98040788
72Attenuation of retinal blood vessels (HP:0007843)1.97341983
73Abnormality of serine family amino acid metabolism (HP:0010894)1.96853063
74Abnormality of glycine metabolism (HP:0010895)1.96853063
75Type 2 muscle fiber atrophy (HP:0003554)1.96788330
76Abnormality of the renal collecting system (HP:0004742)1.96729047
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96160647
78Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96160647
79Increased muscle lipid content (HP:0009058)1.94319374
80Nephronophthisis (HP:0000090)1.94229676
81Sensory axonal neuropathy (HP:0003390)1.89514851
82CNS demyelination (HP:0007305)1.89076792
83Abnormality of the vitamin B12 metabolism (HP:0004341)1.89070002
84Abnormal lung lobation (HP:0002101)1.88620256
85Abnormality of sulfur amino acid metabolism (HP:0004339)1.87315180
86Megaloblastic anemia (HP:0001889)1.84809781
87Hyperglycinuria (HP:0003108)1.84431739
88Abnormality of vitamin B metabolism (HP:0004340)1.83944876
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.82913797
90Increased IgM level (HP:0003496)1.82399178
91Hyperphosphaturia (HP:0003109)1.80434420
92Bile duct proliferation (HP:0001408)1.78533781
93Abnormal biliary tract physiology (HP:0012439)1.78533781
94Abnormality of renal resorption (HP:0011038)1.77180074
95Abnormality of the preputium (HP:0100587)1.76521347
96Homocystinuria (HP:0002156)1.76200825
97Abnormality of homocysteine metabolism (HP:0010919)1.76200825
98Type I transferrin isoform profile (HP:0003642)1.73540445
99Amniotic constriction ring (HP:0009775)1.73276727
100Abnormality of placental membranes (HP:0011409)1.73276727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.10496966
2VRK23.87898881
3EIF2AK33.78974748
4BUB13.51929156
5MST43.25031399
6NEK12.89210689
7EIF2AK12.71747416
8NUAK12.71027672
9ZAK2.55557558
10PLK32.41671101
11SRPK12.33873905
12PBK2.28471257
13VRK12.13455233
14MKNK12.02268251
15NME11.98841745
16MKNK21.87068687
17ADRBK21.85825319
18TRIM281.80709093
19STK161.80187745
20TLK11.79300725
21TAF11.72891253
22CDC71.71403413
23TXK1.54503349
24EIF2AK21.49194238
25GRK11.43921306
26MAP3K121.41086516
27WNK31.37563296
28PLK41.36997520
29TTK1.36196532
30MAP4K21.32718559
31TNIK1.32119364
32PASK1.31368930
33WNK41.30792093
34OXSR11.25590833
35ALK1.16250813
36STK391.11763263
37FRK1.07204011
38TAOK31.05722713
39CDK191.02418041
40PLK11.02353817
41BMPR1B0.99772551
42DAPK10.99692423
43ERBB30.96653840
44DYRK20.93935451
45TIE10.83989242
46PLK20.82664466
47ATR0.76311414
48AURKB0.75056611
49TEC0.73222448
50PDK20.69714175
51ACVR1B0.69347068
52BRSK20.64455724
53CSNK1G10.63525263
54PAK40.61979472
55BCR0.61898567
56MYLK0.60704283
57SCYL20.59976129
58STK38L0.59704997
59CSNK1G30.59080834
60FGFR10.57858838
61INSRR0.55219231
62CSNK2A20.54829952
63IKBKB0.53316064
64NME20.52055774
65CSNK2A10.50639361
66BCKDK0.49933420
67TGFBR10.49772945
68CSNK1G20.48081917
69BMPR20.46722393
70WEE10.46614937
71FLT30.45270870
72ADRBK10.43852447
73CHEK20.43804224
74PRKCE0.43520223
75STK30.43371168
76RPS6KA50.42182041
77CSNK1A1L0.41154569
78CSNK1E0.40259231
79RPS6KA40.39080982
80STK40.38139956
81KDR0.37753587
82NEK20.37703398
83DAPK30.36405510
84ILK0.35013970
85ATM0.34193363
86PRKCG0.32190387
87BRSK10.32114236
88DAPK20.30942796
89CLK10.30860181
90CSNK1A10.30652586
91JAK30.30361232
92MAPKAPK50.29098375
93MAP3K40.28163627
94PHKG10.27702721
95PHKG20.27702721
96CDK70.27630595
97PIK3CG0.27094698
98CHEK10.27024751
99PRKCQ0.25904901
100BRD40.25238971

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.09667713
2Protein export_Homo sapiens_hsa030603.26646165
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04512684
4Oxidative phosphorylation_Homo sapiens_hsa001903.02096549
5One carbon pool by folate_Homo sapiens_hsa006702.84473454
6Ribosome_Homo sapiens_hsa030102.74709492
7Parkinsons disease_Homo sapiens_hsa050122.55897565
8RNA polymerase_Homo sapiens_hsa030202.51291591
9Mismatch repair_Homo sapiens_hsa034302.47999681
10Asthma_Homo sapiens_hsa053102.44028781
11DNA replication_Homo sapiens_hsa030302.26178959
12Homologous recombination_Homo sapiens_hsa034402.20778732
13RNA transport_Homo sapiens_hsa030132.04330053
14Basal transcription factors_Homo sapiens_hsa030221.93527109
15RNA degradation_Homo sapiens_hsa030181.90206710
16Spliceosome_Homo sapiens_hsa030401.88288337
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81622034
18Allograft rejection_Homo sapiens_hsa053301.78150890
19Non-homologous end-joining_Homo sapiens_hsa034501.74187852
20Base excision repair_Homo sapiens_hsa034101.72262189
21Huntingtons disease_Homo sapiens_hsa050161.71298322
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70255902
23Nucleotide excision repair_Homo sapiens_hsa034201.59324066
24Autoimmune thyroid disease_Homo sapiens_hsa053201.58722986
25Propanoate metabolism_Homo sapiens_hsa006401.54469550
26Alzheimers disease_Homo sapiens_hsa050101.52126587
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.51483409
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.49114711
29Type I diabetes mellitus_Homo sapiens_hsa049401.37043938
30Vitamin B6 metabolism_Homo sapiens_hsa007501.31796468
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29904293
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28422224
33Pyrimidine metabolism_Homo sapiens_hsa002401.25608362
34Fanconi anemia pathway_Homo sapiens_hsa034601.23626016
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22926277
36Purine metabolism_Homo sapiens_hsa002301.13369379
37Primary immunodeficiency_Homo sapiens_hsa053401.10415582
38Phototransduction_Homo sapiens_hsa047441.04472617
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03950352
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03474666
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01548292
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00693449
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99928070
44Graft-versus-host disease_Homo sapiens_hsa053320.97128402
45Caffeine metabolism_Homo sapiens_hsa002320.94138646
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93970790
47Glutathione metabolism_Homo sapiens_hsa004800.91013103
48Selenocompound metabolism_Homo sapiens_hsa004500.88509486
49Pyruvate metabolism_Homo sapiens_hsa006200.82546994
50Cardiac muscle contraction_Homo sapiens_hsa042600.77862894
51Cell cycle_Homo sapiens_hsa041100.74767389
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73664421
53Sulfur metabolism_Homo sapiens_hsa009200.73615376
54Rheumatoid arthritis_Homo sapiens_hsa053230.73109595
55Peroxisome_Homo sapiens_hsa041460.72925611
56Butanoate metabolism_Homo sapiens_hsa006500.67411983
57Folate biosynthesis_Homo sapiens_hsa007900.66790616
58Collecting duct acid secretion_Homo sapiens_hsa049660.66390057
59Steroid biosynthesis_Homo sapiens_hsa001000.66030930
60Tryptophan metabolism_Homo sapiens_hsa003800.65366771
61Nitrogen metabolism_Homo sapiens_hsa009100.64756437
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64702890
63Antigen processing and presentation_Homo sapiens_hsa046120.63769104
64Metabolic pathways_Homo sapiens_hsa011000.61756206
65mRNA surveillance pathway_Homo sapiens_hsa030150.61042222
66Linoleic acid metabolism_Homo sapiens_hsa005910.59615526
67Retinol metabolism_Homo sapiens_hsa008300.55260751
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54327852
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53338821
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52983373
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.50982400
72Sulfur relay system_Homo sapiens_hsa041220.48790598
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48388915
74Hematopoietic cell lineage_Homo sapiens_hsa046400.48105720
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47426312
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46467442
77p53 signaling pathway_Homo sapiens_hsa041150.46365702
78Epstein-Barr virus infection_Homo sapiens_hsa051690.46122021
79Biosynthesis of amino acids_Homo sapiens_hsa012300.45662545
80Regulation of autophagy_Homo sapiens_hsa041400.45575910
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45397002
82beta-Alanine metabolism_Homo sapiens_hsa004100.44953633
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43286009
84Carbon metabolism_Homo sapiens_hsa012000.42308974
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41792267
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41375075
87Fatty acid elongation_Homo sapiens_hsa000620.40974876
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39974691
89Systemic lupus erythematosus_Homo sapiens_hsa053220.36156590
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.35886536
91Chemical carcinogenesis_Homo sapiens_hsa052040.34195268
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33864333
93Vitamin digestion and absorption_Homo sapiens_hsa049770.33799972
94Arginine biosynthesis_Homo sapiens_hsa002200.31638852
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29389804
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29054253
97Fatty acid degradation_Homo sapiens_hsa000710.28751349
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27300186
99Legionellosis_Homo sapiens_hsa051340.26583332
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.26074922

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