

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.02529598 |
| 2 | DNA deamination (GO:0045006) | 4.73842179 |
| 3 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.68677419 |
| 4 | regulation of chronic inflammatory response (GO:0002676) | 4.59472956 |
| 5 | regulation of immunoglobulin secretion (GO:0051023) | 4.52667558 |
| 6 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.41613971 |
| 7 | protein-cofactor linkage (GO:0018065) | 4.24585509 |
| 8 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.93296215 |
| 9 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.92784088 |
| 10 | positive regulation of prostaglandin secretion (GO:0032308) | 3.87350561 |
| 11 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.86627721 |
| 12 | positive regulation of DNA recombination (GO:0045911) | 3.81759578 |
| 13 | positive regulation of isotype switching (GO:0045830) | 3.81510578 |
| 14 | ribosomal small subunit assembly (GO:0000028) | 3.74475313 |
| 15 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.71584911 |
| 16 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.69098443 |
| 17 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.65429051 |
| 18 | termination of RNA polymerase III transcription (GO:0006386) | 3.65429051 |
| 19 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.62531922 |
| 20 | chaperone-mediated protein transport (GO:0072321) | 3.60583250 |
| 21 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.58382222 |
| 22 | ATP synthesis coupled proton transport (GO:0015986) | 3.58382222 |
| 23 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.58189617 |
| 24 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.54809733 |
| 25 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.53004144 |
| 26 | negative regulation of ligase activity (GO:0051352) | 3.53001752 |
| 27 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.53001752 |
| 28 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.50731483 |
| 29 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.47835462 |
| 30 | DNA double-strand break processing (GO:0000729) | 3.47506050 |
| 31 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.46621928 |
| 32 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.46621928 |
| 33 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.46621928 |
| 34 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.46481231 |
| 35 | regulation of regulatory T cell differentiation (GO:0045589) | 3.41396798 |
| 36 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.40434475 |
| 37 | rRNA modification (GO:0000154) | 3.38788315 |
| 38 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.36316956 |
| 39 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.36316956 |
| 40 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.34087810 |
| 41 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.34087810 |
| 42 | pseudouridine synthesis (GO:0001522) | 3.32841438 |
| 43 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.27662812 |
| 44 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.27662812 |
| 45 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.26278562 |
| 46 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.24893701 |
| 47 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.23419741 |
| 48 | isotype switching (GO:0045190) | 3.23419741 |
| 49 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.23419741 |
| 50 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.21878333 |
| 51 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.21679935 |
| 52 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.21679935 |
| 53 | protein deneddylation (GO:0000338) | 3.20640633 |
| 54 | regulation of prostaglandin secretion (GO:0032306) | 3.18391060 |
| 55 | cullin deneddylation (GO:0010388) | 3.17605816 |
| 56 | ribosome biogenesis (GO:0042254) | 3.16855419 |
| 57 | ribosome assembly (GO:0042255) | 3.15065103 |
| 58 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.10766865 |
| 59 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.10007205 |
| 60 | rRNA processing (GO:0006364) | 3.09932740 |
| 61 | positive regulation of fatty acid transport (GO:2000193) | 3.08843924 |
| 62 | ribosomal large subunit biogenesis (GO:0042273) | 3.08387620 |
| 63 | protein complex biogenesis (GO:0070271) | 3.06747832 |
| 64 | rRNA metabolic process (GO:0016072) | 3.05916646 |
| 65 | DNA replication checkpoint (GO:0000076) | 3.04609020 |
| 66 | maturation of 5.8S rRNA (GO:0000460) | 3.02879319 |
| 67 | GTP biosynthetic process (GO:0006183) | 2.99497344 |
| 68 | protein neddylation (GO:0045116) | 2.98189854 |
| 69 | rRNA methylation (GO:0031167) | 2.96256908 |
| 70 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.95494260 |
| 71 | positive regulation of B cell mediated immunity (GO:0002714) | 2.95494260 |
| 72 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.95032709 |
| 73 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.93661063 |
| 74 | positive regulation of icosanoid secretion (GO:0032305) | 2.93250587 |
| 75 | positive regulation of ligase activity (GO:0051351) | 2.92928216 |
| 76 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.90254344 |
| 77 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.89662419 |
| 78 | tRNA processing (GO:0008033) | 2.88786362 |
| 79 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.85869280 |
| 80 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.84149863 |
| 81 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.84149863 |
| 82 | NADH dehydrogenase complex assembly (GO:0010257) | 2.84149863 |
| 83 | cellular component biogenesis (GO:0044085) | 2.80463556 |
| 84 | positive regulation of immunoglobulin production (GO:0002639) | 2.78528536 |
| 85 | tRNA metabolic process (GO:0006399) | 2.78429279 |
| 86 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.76229225 |
| 87 | positive regulation of cell cycle arrest (GO:0071158) | 2.76199174 |
| 88 | maturation of SSU-rRNA (GO:0030490) | 2.76062331 |
| 89 | spliceosomal snRNP assembly (GO:0000387) | 2.74906672 |
| 90 | respiratory electron transport chain (GO:0022904) | 2.73970089 |
| 91 | electron transport chain (GO:0022900) | 2.73073315 |
| 92 | respiratory chain complex IV assembly (GO:0008535) | 2.71951743 |
| 93 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.69978337 |
| 94 | ncRNA metabolic process (GO:0034660) | 2.68747606 |
| 95 | chromatin remodeling at centromere (GO:0031055) | 2.68055871 |
| 96 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.67477483 |
| 97 | translation (GO:0006412) | 2.65630312 |
| 98 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.65591535 |
| 99 | mannosylation (GO:0097502) | 2.65250446 |
| 100 | protein K6-linked ubiquitination (GO:0085020) | 2.65081104 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.09180106 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.56919804 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.34802558 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.57069772 |
| 5 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.41420285 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.29199950 |
| 7 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.97122788 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.92270425 |
| 9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.91797790 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.87515362 |
| 11 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.83736225 |
| 12 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.73638876 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.67824814 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.62733872 |
| 15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.53195800 |
| 16 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.43523078 |
| 17 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.41560606 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.26568481 |
| 19 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.21717416 |
| 20 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.21639014 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 2.15616286 |
| 22 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.94229854 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.90413541 |
| 24 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.84588511 |
| 25 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.81778205 |
| 26 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.77086467 |
| 27 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.76736728 |
| 28 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.75638906 |
| 29 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.71130535 |
| 30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.69327916 |
| 31 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.64641462 |
| 32 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.63924755 |
| 33 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.63350113 |
| 34 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.59838560 |
| 35 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.55767033 |
| 36 | EWS_26573619_Chip-Seq_HEK293_Human | 1.54869523 |
| 37 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.53007473 |
| 38 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.52003409 |
| 39 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.50709580 |
| 40 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.45542949 |
| 41 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.45342889 |
| 42 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.44834641 |
| 43 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.44263332 |
| 44 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.43788790 |
| 45 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.43762192 |
| 46 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.42520641 |
| 47 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.40201936 |
| 48 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.36931139 |
| 49 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.36216211 |
| 50 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.32705633 |
| 51 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.32705633 |
| 52 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.30086652 |
| 53 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.29467821 |
| 54 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.28745139 |
| 55 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.27003636 |
| 56 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.26033645 |
| 57 | GATA3_26560356_Chip-Seq_TH2_Human | 1.25778495 |
| 58 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.25337457 |
| 59 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.24007274 |
| 60 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.22966611 |
| 61 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.20177716 |
| 62 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.19128014 |
| 63 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.19117501 |
| 64 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16717150 |
| 65 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.16234102 |
| 66 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.13556273 |
| 67 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.12594800 |
| 68 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.11266345 |
| 69 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.09215670 |
| 70 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.08339972 |
| 71 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.05867712 |
| 72 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.04646330 |
| 73 | AR_20517297_ChIP-Seq_VCAP_Human | 1.04145809 |
| 74 | FUS_26573619_Chip-Seq_HEK293_Human | 1.03842222 |
| 75 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.03407775 |
| 76 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.03103703 |
| 77 | MYB_26560356_Chip-Seq_TH2_Human | 1.01886304 |
| 78 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.01585394 |
| 79 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.00040828 |
| 80 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.99531397 |
| 81 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.99440049 |
| 82 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.97367344 |
| 83 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.96584206 |
| 84 | NCOR_22424771_ChIP-Seq_293T_Human | 0.95861432 |
| 85 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.95427380 |
| 86 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.95097667 |
| 87 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.95097667 |
| 88 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.94428676 |
| 89 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.93068786 |
| 90 | P300_19829295_ChIP-Seq_ESCs_Human | 0.92471322 |
| 91 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.88572347 |
| 92 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.88504364 |
| 93 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.88321863 |
| 94 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88014528 |
| 95 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.87779193 |
| 96 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.86229508 |
| 97 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.85656439 |
| 98 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.85067171 |
| 99 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84925087 |
| 100 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.84437954 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004147_increased_porphyrin_level | 3.95634170 |
| 2 | MP0000685_abnormal_immune_system | 3.55389033 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.53063937 |
| 4 | MP0005671_abnormal_response_to | 3.17076123 |
| 5 | MP0002138_abnormal_hepatobiliary_system | 3.13590354 |
| 6 | MP0005360_urolithiasis | 2.84283517 |
| 7 | MP0003693_abnormal_embryo_hatching | 2.78918795 |
| 8 | MP0001873_stomach_inflammation | 2.35700134 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.26917242 |
| 10 | MP0002102_abnormal_ear_morphology | 2.24711188 |
| 11 | MP0004957_abnormal_blastocyst_morpholog | 2.19291620 |
| 12 | MP0008875_abnormal_xenobiotic_pharmacok | 2.15258277 |
| 13 | MP0001790_abnormal_immune_system | 2.14083452 |
| 14 | MP0005387_immune_system_phenotype | 2.14083452 |
| 15 | MP0008058_abnormal_DNA_repair | 2.10657071 |
| 16 | MP0010094_abnormal_chromosome_stability | 2.09743830 |
| 17 | MP0002148_abnormal_hypersensitivity_rea | 2.08877884 |
| 18 | MP0003806_abnormal_nucleotide_metabolis | 2.08187197 |
| 19 | MP0008872_abnormal_physiological_respon | 2.02413785 |
| 20 | MP0003646_muscle_fatigue | 2.01468718 |
| 21 | MP0003786_premature_aging | 1.97401665 |
| 22 | MP0003718_maternal_effect | 1.89012182 |
| 23 | MP0004145_abnormal_muscle_electrophysio | 1.86271625 |
| 24 | MP0009333_abnormal_splenocyte_physiolog | 1.82278284 |
| 25 | MP0001853_heart_inflammation | 1.72658160 |
| 26 | MP0003195_calcinosis | 1.71807601 |
| 27 | MP0001348_abnormal_lacrimal_gland | 1.71795489 |
| 28 | MP0004782_abnormal_surfactant_physiolog | 1.59418053 |
| 29 | MP0001800_abnormal_humoral_immune | 1.57924546 |
| 30 | MP0008057_abnormal_DNA_replication | 1.54718889 |
| 31 | MP0002006_tumorigenesis | 1.51868181 |
| 32 | MP0004885_abnormal_endolymph | 1.47251744 |
| 33 | MP0003763_abnormal_thymus_physiology | 1.45601315 |
| 34 | MP0002166_altered_tumor_susceptibility | 1.41532511 |
| 35 | MP0006292_abnormal_olfactory_placode | 1.41243938 |
| 36 | MP0005000_abnormal_immune_tolerance | 1.38811994 |
| 37 | MP0009785_altered_susceptibility_to | 1.38668051 |
| 38 | MP0005646_abnormal_pituitary_gland | 1.36422383 |
| 39 | MP0006072_abnormal_retinal_apoptosis | 1.25114122 |
| 40 | MP0002277_abnormal_respiratory_mucosa | 1.24279059 |
| 41 | MP0001501_abnormal_sleep_pattern | 1.23117459 |
| 42 | MP0006036_abnormal_mitochondrial_physio | 1.20435265 |
| 43 | MP0005084_abnormal_gallbladder_morpholo | 1.20083210 |
| 44 | MP0003111_abnormal_nucleus_morphology | 1.19831116 |
| 45 | MP0003077_abnormal_cell_cycle | 1.19395337 |
| 46 | MP0003880_abnormal_central_pattern | 1.18896461 |
| 47 | MP0002736_abnormal_nociception_after | 1.18341581 |
| 48 | MP0001968_abnormal_touch/_nociception | 1.18236289 |
| 49 | MP0002723_abnormal_immune_serum | 1.16034763 |
| 50 | MP0003436_decreased_susceptibility_to | 1.14433112 |
| 51 | MP0002405_respiratory_system_inflammati | 1.14304503 |
| 52 | MP0005645_abnormal_hypothalamus_physiol | 1.11717692 |
| 53 | MP0002420_abnormal_adaptive_immunity | 1.10642642 |
| 54 | MP0002398_abnormal_bone_marrow | 1.10235312 |
| 55 | MP0000689_abnormal_spleen_morphology | 1.09791255 |
| 56 | MP0001819_abnormal_immune_cell | 1.08490627 |
| 57 | MP0005083_abnormal_biliary_tract | 1.08168344 |
| 58 | MP0003567_abnormal_fetal_cardiomyocyte | 1.05747958 |
| 59 | MP0005389_reproductive_system_phenotype | 1.05379866 |
| 60 | MP0003186_abnormal_redox_activity | 1.05040907 |
| 61 | MP0003878_abnormal_ear_physiology | 1.04509955 |
| 62 | MP0005377_hearing/vestibular/ear_phenot | 1.04509955 |
| 63 | MP0002160_abnormal_reproductive_system | 1.04223285 |
| 64 | MP0008007_abnormal_cellular_replicative | 1.01141987 |
| 65 | MP0004142_abnormal_muscle_tone | 1.00742076 |
| 66 | MP0006035_abnormal_mitochondrial_morpho | 1.00079125 |
| 67 | MP0002876_abnormal_thyroid_physiology | 0.99971550 |
| 68 | MP0003936_abnormal_reproductive_system | 0.98685804 |
| 69 | MP0005551_abnormal_eye_electrophysiolog | 0.98047391 |
| 70 | MP0001881_abnormal_mammary_gland | 0.97634321 |
| 71 | MP0002722_abnormal_immune_system | 0.97494608 |
| 72 | MP0000716_abnormal_immune_system | 0.97084563 |
| 73 | MP0003866_abnormal_defecation | 0.96975148 |
| 74 | MP0000703_abnormal_thymus_morphology | 0.96396745 |
| 75 | MP0005636_abnormal_mineral_homeostasis | 0.94660863 |
| 76 | MP0000383_abnormal_hair_follicle | 0.94283487 |
| 77 | MP0001919_abnormal_reproductive_system | 0.94162584 |
| 78 | MP0002452_abnormal_antigen_presenting | 0.92804267 |
| 79 | MP0008932_abnormal_embryonic_tissue | 0.92305051 |
| 80 | MP0001293_anophthalmia | 0.92087584 |
| 81 | MP0002653_abnormal_ependyma_morphology | 0.89616453 |
| 82 | MP0002210_abnormal_sex_determination | 0.89269869 |
| 83 | MP0002429_abnormal_blood_cell | 0.88444715 |
| 84 | MP0005410_abnormal_fertilization | 0.88319475 |
| 85 | MP0001661_extended_life_span | 0.86932751 |
| 86 | MP0005085_abnormal_gallbladder_physiolo | 0.83156005 |
| 87 | MP0005025_abnormal_response_to | 0.81898430 |
| 88 | MP0009764_decreased_sensitivity_to | 0.78020931 |
| 89 | MP0005379_endocrine/exocrine_gland_phen | 0.76860609 |
| 90 | MP0001929_abnormal_gametogenesis | 0.76735911 |
| 91 | MP0002163_abnormal_gland_morphology | 0.75326176 |
| 92 | MP0001119_abnormal_female_reproductive | 0.73321828 |
| 93 | MP0001845_abnormal_inflammatory_respons | 0.73254698 |
| 94 | MP0001984_abnormal_olfaction | 0.73097388 |
| 95 | MP0002938_white_spotting | 0.72638539 |
| 96 | MP0005075_abnormal_melanosome_morpholog | 0.71920394 |
| 97 | MP0009840_abnormal_foam_cell | 0.71499901 |
| 98 | MP0003011_delayed_dark_adaptation | 0.70136698 |
| 99 | MP0003724_increased_susceptibility_to | 0.68855004 |
| 100 | MP0004215_abnormal_myocardial_fiber | 0.67989704 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased hepatocellular lipid droplets (HP:0006565) | 4.60514836 |
| 2 | Stomatitis (HP:0010280) | 4.38243290 |
| 3 | Lipid accumulation in hepatocytes (HP:0006561) | 4.31266304 |
| 4 | Increased CSF lactate (HP:0002490) | 3.96372916 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 3.81072637 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.77223747 |
| 7 | IgG deficiency (HP:0004315) | 3.45462366 |
| 8 | Acute encephalopathy (HP:0006846) | 3.31569428 |
| 9 | Cerebellar dysplasia (HP:0007033) | 3.25630489 |
| 10 | Hepatic necrosis (HP:0002605) | 3.24875461 |
| 11 | Increased serum lactate (HP:0002151) | 3.22527087 |
| 12 | Renal Fanconi syndrome (HP:0001994) | 3.20246204 |
| 13 | Hepatocellular necrosis (HP:0001404) | 3.19532512 |
| 14 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.18653213 |
| 15 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.15451974 |
| 16 | Exertional dyspnea (HP:0002875) | 3.12489979 |
| 17 | Progressive macrocephaly (HP:0004481) | 3.06382175 |
| 18 | Type II lissencephaly (HP:0007260) | 3.03064247 |
| 19 | Increased intramyocellular lipid droplets (HP:0012240) | 2.93109810 |
| 20 | Cerebral edema (HP:0002181) | 2.79044546 |
| 21 | Nephronophthisis (HP:0000090) | 2.74646066 |
| 22 | Pancreatic cysts (HP:0001737) | 2.74419769 |
| 23 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.65093695 |
| 24 | Methylmalonic acidemia (HP:0002912) | 2.58812927 |
| 25 | Renal cortical cysts (HP:0000803) | 2.57247537 |
| 26 | Abnormality of the renal cortex (HP:0011035) | 2.54955668 |
| 27 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.51745897 |
| 28 | Optic disc pallor (HP:0000543) | 2.51374326 |
| 29 | Congenital, generalized hypertrichosis (HP:0004540) | 2.50909966 |
| 30 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.50334442 |
| 31 | Increased muscle lipid content (HP:0009058) | 2.46030620 |
| 32 | 3-Methylglutaconic aciduria (HP:0003535) | 2.44091700 |
| 33 | Lactic acidosis (HP:0003128) | 2.42919010 |
| 34 | Methylmalonic aciduria (HP:0012120) | 2.41496550 |
| 35 | Lethargy (HP:0001254) | 2.39958513 |
| 36 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.39861147 |
| 37 | Aplastic anemia (HP:0001915) | 2.39575983 |
| 38 | Abnormality of the labia minora (HP:0012880) | 2.38865153 |
| 39 | Abnormality of the pons (HP:0007361) | 2.38288029 |
| 40 | Abnormality of urine glucose concentration (HP:0011016) | 2.36467683 |
| 41 | Glycosuria (HP:0003076) | 2.36467683 |
| 42 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.35856983 |
| 43 | Abnormality of alanine metabolism (HP:0010916) | 2.35856983 |
| 44 | Hyperalaninemia (HP:0003348) | 2.35856983 |
| 45 | Abnormality of the renal medulla (HP:0100957) | 2.33747422 |
| 46 | Constricted visual fields (HP:0001133) | 2.31378005 |
| 47 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.30284440 |
| 48 | Respiratory difficulties (HP:0002880) | 2.28923255 |
| 49 | Abolished electroretinogram (ERG) (HP:0000550) | 2.27265450 |
| 50 | Abnormality of T cells (HP:0002843) | 2.24277220 |
| 51 | T lymphocytopenia (HP:0005403) | 2.23728667 |
| 52 | Severe combined immunodeficiency (HP:0004430) | 2.21582553 |
| 53 | Hypoproteinemia (HP:0003075) | 2.21379980 |
| 54 | Pancreatic fibrosis (HP:0100732) | 2.20558936 |
| 55 | Abnormal number of erythroid precursors (HP:0012131) | 2.19581356 |
| 56 | Abnormality of T cell number (HP:0011839) | 2.19201049 |
| 57 | Abnormality of the vocal cords (HP:0008777) | 2.17355917 |
| 58 | Hypoplasia of the pons (HP:0012110) | 2.16925358 |
| 59 | Colon cancer (HP:0003003) | 2.16856670 |
| 60 | Abnormality of midbrain morphology (HP:0002418) | 2.15975909 |
| 61 | Molar tooth sign on MRI (HP:0002419) | 2.15975909 |
| 62 | Respiratory failure (HP:0002878) | 2.15892969 |
| 63 | Increased IgM level (HP:0003496) | 2.13338727 |
| 64 | Congenital stationary night blindness (HP:0007642) | 2.12206437 |
| 65 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.11558710 |
| 66 | Pancytopenia (HP:0001876) | 2.09826597 |
| 67 | Asplenia (HP:0001746) | 2.07152357 |
| 68 | True hermaphroditism (HP:0010459) | 2.05763315 |
| 69 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.04669140 |
| 70 | Meckel diverticulum (HP:0002245) | 2.03618426 |
| 71 | Generalized aminoaciduria (HP:0002909) | 2.02859977 |
| 72 | Leukodystrophy (HP:0002415) | 2.02179276 |
| 73 | Pendular nystagmus (HP:0012043) | 2.01855973 |
| 74 | Tongue fasciculations (HP:0001308) | 2.01812362 |
| 75 | Progressive inability to walk (HP:0002505) | 2.01196699 |
| 76 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.98710932 |
| 77 | Reticulocytopenia (HP:0001896) | 1.98498049 |
| 78 | Abnormality of T cell physiology (HP:0011840) | 1.98233720 |
| 79 | Decreased circulating renin level (HP:0003351) | 1.97481951 |
| 80 | Abnormality of the ileum (HP:0001549) | 1.96169625 |
| 81 | Exercise intolerance (HP:0003546) | 1.88297405 |
| 82 | Severe muscular hypotonia (HP:0006829) | 1.88215363 |
| 83 | Abnormality of serum amino acid levels (HP:0003112) | 1.87645474 |
| 84 | Abnormality of the renal collecting system (HP:0004742) | 1.87497344 |
| 85 | Absent thumb (HP:0009777) | 1.86041360 |
| 86 | Horseshoe kidney (HP:0000085) | 1.83593979 |
| 87 | Type I transferrin isoform profile (HP:0003642) | 1.81797874 |
| 88 | Clubbing of toes (HP:0100760) | 1.78608169 |
| 89 | Cerebral hypomyelination (HP:0006808) | 1.78234799 |
| 90 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.78074275 |
| 91 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.77974783 |
| 92 | Abnormality of renal resorption (HP:0011038) | 1.76582035 |
| 93 | Duplicated collecting system (HP:0000081) | 1.75814109 |
| 94 | Neutropenia (HP:0001875) | 1.75529624 |
| 95 | Palpitations (HP:0001962) | 1.74497849 |
| 96 | Thyroiditis (HP:0100646) | 1.73296801 |
| 97 | Attenuation of retinal blood vessels (HP:0007843) | 1.72872369 |
| 98 | Combined immunodeficiency (HP:0005387) | 1.72773952 |
| 99 | Decreased central vision (HP:0007663) | 1.72484459 |
| 100 | Macrocytic anemia (HP:0001972) | 1.71802313 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ZAK | 3.70111382 |
| 2 | PBK | 3.65145484 |
| 3 | VRK2 | 3.63433926 |
| 4 | TSSK6 | 3.57825490 |
| 5 | TXK | 3.16968972 |
| 6 | BMPR1B | 3.14177442 |
| 7 | MST4 | 2.81675751 |
| 8 | BUB1 | 2.70278665 |
| 9 | TLK1 | 2.70207321 |
| 10 | BCKDK | 2.64364192 |
| 11 | TAOK3 | 2.50009159 |
| 12 | CDK8 | 2.49431486 |
| 13 | EIF2AK3 | 2.34338364 |
| 14 | NUAK1 | 2.28895640 |
| 15 | WNK4 | 2.05151630 |
| 16 | VRK1 | 1.99419989 |
| 17 | EIF2AK1 | 1.94699010 |
| 18 | TGFBR1 | 1.92083378 |
| 19 | SRPK1 | 1.91078220 |
| 20 | NME1 | 1.90170131 |
| 21 | PLK3 | 1.82538383 |
| 22 | MKNK2 | 1.78082515 |
| 23 | GRK1 | 1.68185979 |
| 24 | MAP2K6 | 1.63872094 |
| 25 | TAF1 | 1.48877331 |
| 26 | ADRBK2 | 1.41250267 |
| 27 | MKNK1 | 1.38270995 |
| 28 | MAPKAPK3 | 1.37394731 |
| 29 | WNK3 | 1.22617656 |
| 30 | EIF2AK2 | 1.20161623 |
| 31 | FRK | 1.17247652 |
| 32 | STK39 | 1.13810089 |
| 33 | TRIM28 | 1.13576482 |
| 34 | PLK4 | 1.11850222 |
| 35 | CDC7 | 1.07945846 |
| 36 | ALK | 0.99963578 |
| 37 | OXSR1 | 0.99490179 |
| 38 | TNK2 | 0.98819521 |
| 39 | PDK2 | 0.98815988 |
| 40 | TEC | 0.96159403 |
| 41 | MUSK | 0.95465835 |
| 42 | PLK2 | 0.93340514 |
| 43 | MAP4K2 | 0.91714334 |
| 44 | ITK | 0.91486803 |
| 45 | IKBKB | 0.86872522 |
| 46 | STK16 | 0.86208578 |
| 47 | TESK2 | 0.84802855 |
| 48 | TTK | 0.82215679 |
| 49 | MAP2K2 | 0.81715266 |
| 50 | IKBKE | 0.79106610 |
| 51 | DAPK1 | 0.78864015 |
| 52 | KDR | 0.78779914 |
| 53 | MAP4K1 | 0.77116006 |
| 54 | TIE1 | 0.69446619 |
| 55 | PLK1 | 0.69088276 |
| 56 | MAP3K14 | 0.66240269 |
| 57 | PASK | 0.65868449 |
| 58 | NEK1 | 0.65815327 |
| 59 | KIT | 0.63214497 |
| 60 | RPS6KA4 | 0.62155884 |
| 61 | ACVR1B | 0.61435296 |
| 62 | MAP3K12 | 0.54694809 |
| 63 | TNIK | 0.54505243 |
| 64 | GRK5 | 0.53361955 |
| 65 | ATR | 0.53064835 |
| 66 | CDK9 | 0.51725248 |
| 67 | PIK3CG | 0.49621826 |
| 68 | WEE1 | 0.49278310 |
| 69 | RPS6KA5 | 0.48953318 |
| 70 | LCK | 0.44533072 |
| 71 | STK38L | 0.44505201 |
| 72 | INSRR | 0.44390208 |
| 73 | PRKCQ | 0.42909767 |
| 74 | BMPR2 | 0.42143655 |
| 75 | MAPKAPK5 | 0.39130801 |
| 76 | CSNK2A2 | 0.37942358 |
| 77 | CSNK1G3 | 0.37487277 |
| 78 | MAP2K7 | 0.37280048 |
| 79 | MAP3K13 | 0.37271833 |
| 80 | SYK | 0.35546305 |
| 81 | FLT3 | 0.35308318 |
| 82 | BTK | 0.34762262 |
| 83 | TESK1 | 0.34571254 |
| 84 | CSNK2A1 | 0.31431019 |
| 85 | JAK3 | 0.31383533 |
| 86 | ADRBK1 | 0.28736080 |
| 87 | CSNK1G1 | 0.28070738 |
| 88 | GRK7 | 0.27711403 |
| 89 | AURKB | 0.26997385 |
| 90 | PRKCG | 0.25236272 |
| 91 | IGF1R | 0.24570077 |
| 92 | STK4 | 0.23507759 |
| 93 | CSNK1E | 0.21965817 |
| 94 | PHKG2 | 0.21117294 |
| 95 | PHKG1 | 0.21117294 |
| 96 | FGFR1 | 0.20467604 |
| 97 | ATM | 0.20301594 |
| 98 | PAK3 | 0.19375869 |
| 99 | PRKCI | 0.18901173 |
| 100 | CSNK1A1 | 0.18258969 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.92849508 |
| 2 | RNA polymerase_Homo sapiens_hsa03020 | 3.05226743 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.93258282 |
| 4 | Protein export_Homo sapiens_hsa03060 | 2.91943609 |
| 5 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.79214318 |
| 6 | Ribosome_Homo sapiens_hsa03010 | 2.70957816 |
| 7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.63342022 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.27452814 |
| 9 | Allograft rejection_Homo sapiens_hsa05330 | 2.25969374 |
| 10 | RNA degradation_Homo sapiens_hsa03018 | 2.19694429 |
| 11 | Asthma_Homo sapiens_hsa05310 | 2.18983024 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.11937031 |
| 13 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.09180029 |
| 14 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.05468645 |
| 15 | Mismatch repair_Homo sapiens_hsa03430 | 1.98442881 |
| 16 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.97344669 |
| 17 | Homologous recombination_Homo sapiens_hsa03440 | 1.91438818 |
| 18 | DNA replication_Homo sapiens_hsa03030 | 1.81162605 |
| 19 | RNA transport_Homo sapiens_hsa03013 | 1.78628828 |
| 20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.75687099 |
| 21 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.71020257 |
| 22 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.59550585 |
| 23 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.57166737 |
| 24 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.53290791 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.48384396 |
| 26 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.48214019 |
| 27 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.46567053 |
| 28 | Huntingtons disease_Homo sapiens_hsa05016 | 1.45367799 |
| 29 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.44795525 |
| 30 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.36559834 |
| 31 | Phototransduction_Homo sapiens_hsa04744 | 1.36099054 |
| 32 | Spliceosome_Homo sapiens_hsa03040 | 1.33231700 |
| 33 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.30193689 |
| 34 | Purine metabolism_Homo sapiens_hsa00230 | 1.25364770 |
| 35 | Alzheimers disease_Homo sapiens_hsa05010 | 1.23951070 |
| 36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.23136072 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.21918870 |
| 38 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.21209997 |
| 39 | Base excision repair_Homo sapiens_hsa03410 | 1.19228147 |
| 40 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.18856295 |
| 41 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.17724829 |
| 42 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.15598399 |
| 43 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.13895640 |
| 44 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.09830612 |
| 45 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.08820471 |
| 46 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.04771615 |
| 47 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.04627544 |
| 48 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.03450605 |
| 49 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.98719432 |
| 50 | Peroxisome_Homo sapiens_hsa04146 | 0.96085674 |
| 51 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.94524832 |
| 52 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.94014267 |
| 53 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.93250150 |
| 54 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.87489580 |
| 55 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.87160803 |
| 56 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.84409363 |
| 57 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.82011953 |
| 58 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.80237315 |
| 59 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.76680751 |
| 60 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.72285711 |
| 61 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.71513322 |
| 62 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.69341593 |
| 63 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.68174645 |
| 64 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.66849945 |
| 65 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.65237978 |
| 66 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.56873390 |
| 67 | Retinol metabolism_Homo sapiens_hsa00830 | 0.54700624 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.54255965 |
| 69 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.53293373 |
| 70 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.52414851 |
| 71 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.50587053 |
| 72 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.50288553 |
| 73 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.45296871 |
| 74 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.44925045 |
| 75 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.43441451 |
| 76 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.41793322 |
| 77 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.38702751 |
| 78 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.37735591 |
| 79 | Measles_Homo sapiens_hsa05162 | 0.37500776 |
| 80 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.36009233 |
| 81 | ABC transporters_Homo sapiens_hsa02010 | 0.35294810 |
| 82 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.34782457 |
| 83 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.33284078 |
| 84 | Olfactory transduction_Homo sapiens_hsa04740 | 0.32969182 |
| 85 | Mineral absorption_Homo sapiens_hsa04978 | 0.32230645 |
| 86 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.30464919 |
| 87 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.27735817 |
| 88 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.27652985 |
| 89 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.27289755 |
| 90 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.26866323 |
| 91 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.24705617 |
| 92 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.24337271 |
| 93 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.24308321 |
| 94 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.22885750 |
| 95 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.22357327 |
| 96 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.20856208 |
| 97 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.20565642 |
| 98 | Taste transduction_Homo sapiens_hsa04742 | 0.18985671 |
| 99 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.18453828 |
| 100 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.17804846 |

