NPM1P52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1outer ear morphogenesis (GO:0042473)8.22579999
2polyamine biosynthetic process (GO:0006596)7.40892465
3artery development (GO:0060840)7.37411662
4regulation of dopamine uptake involved in synaptic transmission (GO:0051584)6.95043697
5regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)6.95043697
6facial nerve structural organization (GO:0021612)6.83645859
7adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.24701640
8arachidonic acid secretion (GO:0050482)5.88095791
9icosanoid secretion (GO:0032309)5.88095791
10multicellular organismal movement (GO:0050879)5.62188401
11musculoskeletal movement (GO:0050881)5.62188401
12negative regulation of sodium ion transport (GO:0010766)5.61725247
13synaptic transmission, dopaminergic (GO:0001963)5.37431290
14regulation of neurotransmitter uptake (GO:0051580)5.34082002
15low-density lipoprotein particle clearance (GO:0034383)5.25551799
16prepulse inhibition (GO:0060134)5.15660384
17cranial nerve structural organization (GO:0021604)5.15600742
18reflex (GO:0060004)5.04165611
19behavioral response to cocaine (GO:0048148)4.98754218
20regulation of proton transport (GO:0010155)4.98047852
21cellular biogenic amine biosynthetic process (GO:0042401)4.97881927
22response to histamine (GO:0034776)4.96442030
23cellular biogenic amine catabolic process (GO:0042402)4.90163853
24amine catabolic process (GO:0009310)4.90163853
25fatty acid derivative transport (GO:1901571)4.70351022
26icosanoid transport (GO:0071715)4.70351022
27amine biosynthetic process (GO:0009309)4.67508990
28mitochondrion morphogenesis (GO:0070584)4.62103474
29G-protein coupled receptor internalization (GO:0002031)4.57345487
30polyamine metabolic process (GO:0006595)4.51073738
31cardiovascular system development (GO:0072358)4.43030969
32heparan sulfate proteoglycan biosynthetic process (GO:0015012)4.34953682
33negative regulation of oligodendrocyte differentiation (GO:0048715)4.34626119
34regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.10500402
35regulation of isotype switching to IgG isotypes (GO:0048302)4.05615125
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.04569411
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.04569411
38striated muscle atrophy (GO:0014891)3.99671286
39cell morphogenesis involved in neuron differentiation (GO:0048667)3.90992842
40positive regulation of renal sodium excretion (GO:0035815)3.77610355
41ubiquinone biosynthetic process (GO:0006744)3.72636004
42fatty acid homeostasis (GO:0055089)3.65900242
43natural killer cell mediated cytotoxicity (GO:0042267)3.57422923
44natural killer cell mediated immunity (GO:0002228)3.57422923
45CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.52352296
46peristalsis (GO:0030432)3.44014010
47cochlea development (GO:0090102)3.43703597
48regulation of mitochondrial fission (GO:0090140)3.43593485
49regulation of synaptic transmission, dopaminergic (GO:0032225)3.40692432
50skeletal muscle adaptation (GO:0043501)3.32708855
51behavioral response to nicotine (GO:0035095)3.28515577
52ubiquinone metabolic process (GO:0006743)3.26521247
53positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.25485742
54glycerol metabolic process (GO:0006071)3.24238827
55positive regulation of interleukin-17 production (GO:0032740)3.23549991
56muscle atrophy (GO:0014889)3.21656066
57positive regulation of cellular amine metabolic process (GO:0033240)3.17711493
58response to amphetamine (GO:0001975)3.17499617
59cytokine production involved in immune response (GO:0002367)3.16291355
60skeletal muscle tissue regeneration (GO:0043403)3.12303457
61regulation of chronic inflammatory response (GO:0002676)3.10454932
62anatomical structure arrangement (GO:0048532)3.09417075
63negative regulation of mast cell activation (GO:0033004)3.08527292
64regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.06061226
65regulation of circadian sleep/wake cycle (GO:0042749)3.06061226
66regulation of cellular senescence (GO:2000772)3.05931541
67positive regulation of protein homooligomerization (GO:0032464)3.05445982
68negative regulation of glial cell differentiation (GO:0045686)3.04195331
69piRNA metabolic process (GO:0034587)3.01741152
70quinone biosynthetic process (GO:1901663)3.01209508
71auditory receptor cell stereocilium organization (GO:0060088)3.00607289
72phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.99646776
73regulation of interferon-gamma biosynthetic process (GO:0045072)2.99118482
74positive regulation of natural killer cell differentiation (GO:0032825)2.96848506
75snRNA processing (GO:0016180)2.96368088
76production of molecular mediator of immune response (GO:0002440)2.94009710
77negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92924592
78regulation of immunoglobulin secretion (GO:0051023)2.89995134
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88541123
80circadian sleep/wake cycle process (GO:0022410)2.88514568
81spliceosomal complex assembly (GO:0000245)2.84324920
82mitotic cell cycle arrest (GO:0071850)2.82318815
83organic cation transport (GO:0015695)2.81633567
84alditol metabolic process (GO:0019400)2.77752464
85snRNA metabolic process (GO:0016073)2.76529786
86regulation of establishment of cell polarity (GO:2000114)2.74525263
87plasma lipoprotein particle clearance (GO:0034381)2.72793396
88mitochondrial RNA metabolic process (GO:0000959)2.68809990
89DNA deamination (GO:0045006)2.64726425
90regulation of interleukin-8 secretion (GO:2000482)2.62099526
91regulation of cellular respiration (GO:0043457)2.60814333
92proteasome assembly (GO:0043248)2.57431464
93regulation of phospholipase A2 activity (GO:0032429)2.57362059
94nephron tubule morphogenesis (GO:0072078)2.57003676
95nephron epithelium morphogenesis (GO:0072088)2.57003676
96iron ion import (GO:0097286)2.54786027
97grooming behavior (GO:0007625)2.52834460
98rRNA methylation (GO:0031167)2.52424033
99diacylglycerol metabolic process (GO:0046339)2.47343616
100regulation of renal sodium excretion (GO:0035813)2.44112896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse8.27154652
2VDR_22108803_ChIP-Seq_LS180_Human4.67357626
3ZNF274_21170338_ChIP-Seq_K562_Hela4.08860525
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47240366
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.05773642
6GATA1_22025678_ChIP-Seq_K562_Human2.84862945
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.67251048
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66482948
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41266426
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.32505816
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31471957
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.29469630
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23485163
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23485163
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23485163
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.99388546
17IGF1R_20145208_ChIP-Seq_DFB_Human1.94872004
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90217987
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88768636
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87043087
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80737159
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70595289
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.65835732
24GATA3_21878914_ChIP-Seq_MCF-7_Human1.62249452
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60679896
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60232612
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57125634
28BCAT_22108803_ChIP-Seq_LS180_Human1.55281859
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53903251
30VDR_23849224_ChIP-Seq_CD4+_Human1.52144709
31TP53_22573176_ChIP-Seq_HFKS_Human1.47340208
32MYC_18940864_ChIP-ChIP_HL60_Human1.46722192
33AR_21572438_ChIP-Seq_LNCaP_Human1.39050434
34KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35871615
35NANOG_19829295_ChIP-Seq_ESCs_Human1.35033868
36SOX2_19829295_ChIP-Seq_ESCs_Human1.35033868
37ELK1_19687146_ChIP-ChIP_HELA_Human1.34962638
38EWS_26573619_Chip-Seq_HEK293_Human1.33522478
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31928792
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.31928792
41P300_19829295_ChIP-Seq_ESCs_Human1.31006191
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29457625
43ELK4_26923725_Chip-Seq_MESODERM_Mouse1.26557095
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24493180
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.21636801
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21133064
47FLI1_21867929_ChIP-Seq_TH2_Mouse1.20266148
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20236550
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18434628
50LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.16850458
51GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.16505938
52EZH2_22144423_ChIP-Seq_EOC_Human1.16479625
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15192515
54HOXB7_26014856_ChIP-Seq_BT474_Human1.15000310
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13769176
56NCOR_22424771_ChIP-Seq_293T_Human1.13006217
57GATA3_26560356_Chip-Seq_TH2_Human1.12074982
58ER_23166858_ChIP-Seq_MCF-7_Human1.11853002
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.09840691
60GATA3_26560356_Chip-Seq_TH1_Human1.08501425
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04825148
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04426350
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.04023765
64FOXH1_21741376_ChIP-Seq_ESCs_Human1.03919576
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03713293
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03509431
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.03421414
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02821001
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.02698123
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.02300123
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01588738
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.00743397
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99680585
74TAF2_19829295_ChIP-Seq_ESCs_Human0.99547898
75TCF4_23295773_ChIP-Seq_U87_Human0.99470551
76GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.98679494
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95133905
78FOXH1_21741376_ChIP-Seq_EPCs_Human0.95010064
79SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94547097
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94399065
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94354884
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94173207
83TCF4_22108803_ChIP-Seq_LS180_Human0.92395694
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91230569
85FOXP3_21729870_ChIP-Seq_TREG_Human0.90620722
86ERA_21632823_ChIP-Seq_H3396_Human0.90139742
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89853264
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.89735820
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88619969
90RXR_22108803_ChIP-Seq_LS180_Human0.87574437
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86470376
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86311370
93CEBPB_22108803_ChIP-Seq_LS180_Human0.84898413
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.84167579
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83749948
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83480900
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83105896
98CREB1_15753290_ChIP-ChIP_HEK293T_Human0.81985431
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81921775
100GBX2_23144817_ChIP-Seq_PC3_Human0.81027477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008872_abnormal_physiological_respon3.78293610
2MP0000678_abnormal_parathyroid_gland3.60668455
3MP0001873_stomach_inflammation3.31442427
4MP0004145_abnormal_muscle_electrophysio3.19379622
5MP0009046_muscle_twitch3.13263927
6MP0008875_abnormal_xenobiotic_pharmacok2.76864804
7MP0008877_abnormal_DNA_methylation2.42330355
8MP0003646_muscle_fatigue2.35456407
9MP0002735_abnormal_chemical_nociception2.33645468
10MP0004147_increased_porphyrin_level2.29803332
11MP0000569_abnormal_digit_pigmentation2.16707145
12MP0005671_abnormal_response_to2.10902613
13MP0005451_abnormal_body_composition10.6716379
14MP0001905_abnormal_dopamine_level1.98842370
15MP0001348_abnormal_lacrimal_gland1.90378223
16MP0003315_abnormal_perineum_morphology1.89154369
17MP0003718_maternal_effect1.72653307
18MP0002877_abnormal_melanocyte_morpholog1.71801982
19MP0002138_abnormal_hepatobiliary_system1.70332863
20MP0001440_abnormal_grooming_behavior1.69958579
21MP0003195_calcinosis1.67710488
22MP0004742_abnormal_vestibular_system1.63718164
23MP0001835_abnormal_antigen_presentation1.57484745
24MP0002638_abnormal_pupillary_reflex1.54058133
25MP0005387_immune_system_phenotype1.51941414
26MP0001790_abnormal_immune_system1.51941414
27MP0003938_abnormal_ear_development1.48184426
28MP0008007_abnormal_cellular_replicative1.46460209
29MP0000685_abnormal_immune_system1.45307885
30MP0002876_abnormal_thyroid_physiology1.42403369
31MP0004142_abnormal_muscle_tone1.40781772
32MP0001486_abnormal_startle_reflex1.39808619
33MP0009333_abnormal_splenocyte_physiolog1.35171131
34MP0001986_abnormal_taste_sensitivity1.33828734
35MP0000049_abnormal_middle_ear1.23631761
36MP0002108_abnormal_muscle_morphology1.23087099
37MP0001502_abnormal_circadian_rhythm1.15342968
38MP0006072_abnormal_retinal_apoptosis1.13912810
39MP0005620_abnormal_muscle_contractility1.06751113
40MP0002277_abnormal_respiratory_mucosa1.06029173
41MP0004885_abnormal_endolymph1.04973737
42MP0005408_hypopigmentation1.03143105
43MP0002067_abnormal_sensory_capabilities1.02793300
44MP0001800_abnormal_humoral_immune1.02196713
45MP0003567_abnormal_fetal_cardiomyocyte1.00685613
46MP0002733_abnormal_thermal_nociception1.00368706
47MP0009745_abnormal_behavioral_response1.00018182
48MP0005083_abnormal_biliary_tract0.98539454
49MP0002177_abnormal_outer_ear0.98045473
50MP0000230_abnormal_systemic_arterial0.97789673
51MP0004215_abnormal_myocardial_fiber0.96423642
52MP0003959_abnormal_lean_body0.94757560
53MP0002693_abnormal_pancreas_physiology0.92283684
54MP0002102_abnormal_ear_morphology0.89650134
55MP0003119_abnormal_digestive_system0.88688548
56MP0002148_abnormal_hypersensitivity_rea0.87231743
57MP0000747_muscle_weakness0.80494363
58MP0005310_abnormal_salivary_gland0.80338264
59MP0005379_endocrine/exocrine_gland_phen0.79729049
60MP0002332_abnormal_exercise_endurance0.79117532
61MP0001968_abnormal_touch/_nociception0.78126486
62MP0001663_abnormal_digestive_system0.77171717
63MP0001970_abnormal_pain_threshold0.76806947
64MP0004036_abnormal_muscle_relaxation0.75397547
65MP0005369_muscle_phenotype0.75190160
66MP0005501_abnormal_skin_physiology0.74335059
67MP0002796_impaired_skin_barrier0.74319692
68MP0003638_abnormal_response/metabolism_0.73269407
69MP0003806_abnormal_nucleotide_metabolis0.72511605
70MP0006036_abnormal_mitochondrial_physio0.70052574
71MP0003011_delayed_dark_adaptation0.68873737
72MP0005000_abnormal_immune_tolerance0.68429024
73MP0005551_abnormal_eye_electrophysiolog0.67722173
74MP0000703_abnormal_thymus_morphology0.67636839
75MP0003763_abnormal_thymus_physiology0.67271801
76MP0006082_CNS_inflammation0.63716569
77MP0003137_abnormal_impulse_conducting0.63507149
78MP0002452_abnormal_antigen_presenting0.63050756
79MP0005645_abnormal_hypothalamus_physiol0.61674404
80MP0002723_abnormal_immune_serum0.60631120
81MP0010155_abnormal_intestine_physiology0.60193706
82MP0005452_abnormal_adipose_tissue0.58864005
83MP0002106_abnormal_muscle_physiology0.57927998
84MP0005395_other_phenotype0.57331362
85MP0005584_abnormal_enzyme/coenzyme_acti0.55600498
86MP0002069_abnormal_eating/drinking_beha0.55095912
87MP0005253_abnormal_eye_physiology0.54176479
88MP0001756_abnormal_urination0.53722354
89MP0000372_irregular_coat_pigmentation0.52802997
90MP0002420_abnormal_adaptive_immunity0.52583906
91MP0005075_abnormal_melanosome_morpholog0.52011778
92MP0002160_abnormal_reproductive_system0.51913299
93MP0000427_abnormal_hair_cycle0.51781455
94MP0002163_abnormal_gland_morphology0.51096617
95MP0010094_abnormal_chromosome_stability0.50904767
96MP0008873_increased_physiological_sensi0.48562682
97MP0005389_reproductive_system_phenotype0.48150559
98MP0005220_abnormal_exocrine_pancreas0.48132062
99MP0001819_abnormal_immune_cell0.46959847
100MP0005167_abnormal_blood-brain_barrier0.46639200

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)8.24145501
2Short nail (HP:0001799)6.88729185
3Broad distal phalanx of finger (HP:0009836)6.72332243
4Spinal cord compression (HP:0002176)5.83060225
5Radial bowing (HP:0002986)5.69846793
6Large for gestational age (HP:0001520)5.03662313
7Flared iliac wings (HP:0002869)4.61891684
8Cupped ribs (HP:0000887)4.04642001
9Congenital, generalized hypertrichosis (HP:0004540)3.96629334
10Missing ribs (HP:0000921)3.87796649
11Irregular vertebral endplates (HP:0003301)3.80474962
12Bicuspid aortic valve (HP:0001647)3.77805452
13Stomatitis (HP:0010280)3.75164212
14Ovoid vertebral bodies (HP:0003300)3.56647282
15Bowed forearm bones (HP:0003956)3.45242797
16Bowing of the arm (HP:0006488)3.45242797
17Short femoral neck (HP:0100864)3.36638755
18Molar tooth sign on MRI (HP:0002419)3.36047878
19Abnormality of midbrain morphology (HP:0002418)3.36047878
20Pancreatic cysts (HP:0001737)3.35326373
21Hyperventilation (HP:0002883)3.17074842
22Genetic anticipation (HP:0003743)3.14366664
23Abnormal vertebral ossification (HP:0100569)3.05905312
24Abnormality of carpal bone ossification (HP:0006257)3.04467937
25Abnormality of the vertebral endplates (HP:0005106)2.99710375
26Fragile skin (HP:0001030)2.99189054
27Hypoplastic ischia (HP:0003175)2.94395912
28Fair hair (HP:0002286)2.92697752
29Congenital stationary night blindness (HP:0007642)2.86846445
30Delayed gross motor development (HP:0002194)2.86364744
31Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.85775350
32Sparse scalp hair (HP:0002209)2.82259514
33True hermaphroditism (HP:0010459)2.80967570
34Coxa valga (HP:0002673)2.78831055
35Furrowed tongue (HP:0000221)2.74241250
36Aplasia/hypoplasia of the femur (HP:0005613)2.72223086
37Slender long bone (HP:0003100)2.65462755
38Mesangial abnormality (HP:0001966)2.65189382
39Pendular nystagmus (HP:0012043)2.64503173
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.63304434
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63210413
42Abnormality of alanine metabolism (HP:0010916)2.63210413
43Hyperalaninemia (HP:0003348)2.63210413
44Birth length less than 3rd percentile (HP:0003561)2.61751295
45Dislocated radial head (HP:0003083)2.55925674
46Palpebral edema (HP:0100540)2.53348218
47Exostoses (HP:0100777)2.51139464
48Pancreatic fibrosis (HP:0100732)2.50300263
49Abnormality of the radial head (HP:0003995)2.46899163
50Abnormality of the ischium (HP:0003174)2.44902288
51Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.42307303
52Conical tooth (HP:0000698)2.38195685
53Metatarsus adductus (HP:0001840)2.33705102
54Generalized hypopigmentation of hair (HP:0011358)2.33459651
55Carpal synostosis (HP:0009702)2.33185869
56Severe muscular hypotonia (HP:0006829)2.31401410
57Gingivitis (HP:0000230)2.27830997
58Abnormal hand bone ossification (HP:0010660)2.27531068
59Broad-based gait (HP:0002136)2.22673325
60Soft skin (HP:0000977)2.17599899
61Short hallux (HP:0010109)2.16808398
62Hypoplasia of the uterus (HP:0000013)2.10684397
63Inability to walk (HP:0002540)2.10188056
64Aplasia/Hypoplasia of the hallux (HP:0008362)2.05166207
65Cystic liver disease (HP:0006706)2.04147812
66Abnormal ossification of hand bones (HP:0005921)2.02806677
67Dyskinesia (HP:0100660)2.02284100
68Synostosis involving bones of the hand (HP:0004278)2.01626848
69Type 2 muscle fiber atrophy (HP:0003554)1.98519796
70Areflexia of lower limbs (HP:0002522)1.98425296
71Aplasia/hypoplasia of the uterus (HP:0008684)1.96271328
72Duplicated collecting system (HP:0000081)1.92739649
73Chronic diarrhea (HP:0002028)1.92073236
74IgG deficiency (HP:0004315)1.90719132
75Clumsiness (HP:0002312)1.85155099
76Cleft eyelid (HP:0000625)1.84966451
77Broad metatarsal (HP:0001783)1.84508199
78Aplastic anemia (HP:0001915)1.83456963
79Progressive cerebellar ataxia (HP:0002073)1.82729047
80Severe short stature (HP:0003510)1.80603599
81Ulnar deviation of the wrist (HP:0003049)1.80519924
82Hypoplasia of the ulna (HP:0003022)1.79514025
83Nemaline bodies (HP:0003798)1.79126492
84Abnormality of the renal collecting system (HP:0004742)1.78516012
85Abnormality of the humeroradial joint (HP:0100744)1.76655899
86Patellar aplasia (HP:0006443)1.75704236
87Alveolar cell carcinoma (HP:0006519)1.75619569
88Cerebellar dysplasia (HP:0007033)1.74942983
89Adactyly (HP:0009776)1.72141439
90Abolished electroretinogram (ERG) (HP:0000550)1.71940290
91Progressive microcephaly (HP:0000253)1.71868745
92Aplasia/Hypoplasia of the patella (HP:0006498)1.71817517
93Congenital primary aphakia (HP:0007707)1.71020114
94Gait imbalance (HP:0002141)1.70789217
95Male pseudohermaphroditism (HP:0000037)1.70466041
96Neoplasm of the tracheobronchial system (HP:0100552)1.70401841
97Abnormal delayed hypersensitivity skin test (HP:0002963)1.69796209
98Supernumerary bones of the axial skeleton (HP:0009144)1.69348942
99Diplopia (HP:0000651)1.68573220
100Abnormality of binocular vision (HP:0011514)1.68573220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK24.39418928
2KSR24.13181775
3TLK13.74790214
4NEK13.42018919
5NTRK33.27153998
6ACVR1B3.20052840
7GRK12.99511490
8RAF12.94428322
9KSR12.83144979
10MAP3K22.80635122
11WNK12.71823855
12BMPR1B2.67781358
13MAP3K122.50935465
14TSSK62.34809162
15PAK62.21480832
16TGFBR12.14150145
17TIE11.95889469
18WNK41.87328087
19PBK1.82416234
20PLK41.72662974
21EIF2AK31.71168653
22ZAK1.70304954
23FRK1.69820899
24MKNK21.56802675
25TXK1.52651590
26CLK11.44737087
27NUAK11.35095800
28MKNK11.30912144
29EIF2AK11.25848966
30PDK21.20899457
31MST41.20674651
32DAPK21.16796775
33PAK30.97254780
34CDK80.97165881
35NEK20.95293270
36CDK40.95072078
37VRK20.94466356
38NEK90.94234834
39ITK0.92283174
40NME20.91389482
41VRK10.89079699
42MAP2K10.86080465
43OBSCN0.85255013
44STK390.84774804
45BUB10.82144818
46MAP2K60.78568167
47CSNK1G10.78463779
48CSNK1G30.75220580
49CSNK1A1L0.75116008
50TEC0.71867931
51PIK3CA0.71369593
52MAP3K10.68460175
53PIK3CG0.65371422
54CCNB10.64951018
55BCKDK0.64916920
56MAP4K20.63362125
57CSNK1G20.62368244
58PLK30.61790638
59IKBKB0.61478367
60BMPR20.61028254
61PTK2B0.59469223
62LIMK10.57431661
63EIF2AK20.56117654
64EPHB20.53196543
65SRPK10.51790947
66STK160.50845630
67WNK30.49802825
68PHKG20.48671772
69PHKG10.48671772
70CAMK2D0.47854503
71IRAK10.47554456
72MET0.46725502
73ADRBK10.45704713
74MAP3K90.40934332
75OXSR10.40929812
76LCK0.39707103
77RET0.39502896
78FLT30.35149333
79TRPM70.35121493
80STK240.33550747
81CAMK2G0.32465287
82CAMK2A0.32216952
83RPS6KA50.31301544
84FGFR10.30457175
85PRKCQ0.29746795
86CSNK1D0.29504527
87STK30.26666101
88KIT0.25984501
89MAPKAPK50.25907080
90TNK20.24504300
91SGK10.22758549
92PRKAA20.22495014
93PRKCE0.21534107
94JAK30.18467892
95PRKAA10.17731500
96SYK0.17292308
97FGR0.16970817
98TRIM280.15818368
99DAPK10.15761856
100INSRR0.15516805

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004505.68226448
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.71487864
3Asthma_Homo sapiens_hsa053103.62408486
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.44333686
5Allograft rejection_Homo sapiens_hsa053303.13192088
6Autoimmune thyroid disease_Homo sapiens_hsa053203.03814751
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.01575765
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.98738118
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.88237065
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35755531
11Phototransduction_Homo sapiens_hsa047442.21468906
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.19524034
13Regulation of autophagy_Homo sapiens_hsa041402.12865962
14Proteasome_Homo sapiens_hsa030502.12073951
15Nitrogen metabolism_Homo sapiens_hsa009102.04735403
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01497609
17Ether lipid metabolism_Homo sapiens_hsa005651.71910977
18RNA degradation_Homo sapiens_hsa030181.51558801
19Linoleic acid metabolism_Homo sapiens_hsa005911.51058958
20Protein export_Homo sapiens_hsa030601.50231925
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33072607
22Graft-versus-host disease_Homo sapiens_hsa053321.32506529
23Peroxisome_Homo sapiens_hsa041461.31780963
24Fat digestion and absorption_Homo sapiens_hsa049751.30448621
25Mineral absorption_Homo sapiens_hsa049781.27127449
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26606602
27Primary immunodeficiency_Homo sapiens_hsa053401.21602959
28Type I diabetes mellitus_Homo sapiens_hsa049401.19477499
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12518147
30Parkinsons disease_Homo sapiens_hsa050121.06974856
31Vitamin B6 metabolism_Homo sapiens_hsa007501.06229572
32Cardiac muscle contraction_Homo sapiens_hsa042600.99673154
33Ribosome_Homo sapiens_hsa030100.99377113
34Oxidative phosphorylation_Homo sapiens_hsa001900.98913202
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97917120
36T cell receptor signaling pathway_Homo sapiens_hsa046600.96296919
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95270984
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91322651
39One carbon pool by folate_Homo sapiens_hsa006700.87807880
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86327141
41RNA transport_Homo sapiens_hsa030130.84169764
42Sulfur relay system_Homo sapiens_hsa041220.81266442
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80956871
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80036757
45RNA polymerase_Homo sapiens_hsa030200.77815831
46ABC transporters_Homo sapiens_hsa020100.77749617
47Homologous recombination_Homo sapiens_hsa034400.77455053
48Glycerolipid metabolism_Homo sapiens_hsa005610.76084996
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74963426
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74166822
51Pyrimidine metabolism_Homo sapiens_hsa002400.71089863
52Circadian rhythm_Homo sapiens_hsa047100.68966385
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.66655283
54Viral myocarditis_Homo sapiens_hsa054160.64498962
55Dorso-ventral axis formation_Homo sapiens_hsa043200.62675947
56Caffeine metabolism_Homo sapiens_hsa002320.58482722
57Sulfur metabolism_Homo sapiens_hsa009200.58224897
58Hematopoietic cell lineage_Homo sapiens_hsa046400.57952940
59Rheumatoid arthritis_Homo sapiens_hsa053230.57166716
60Butanoate metabolism_Homo sapiens_hsa006500.56377790
61Legionellosis_Homo sapiens_hsa051340.54335042
62Basal transcription factors_Homo sapiens_hsa030220.50841169
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.49983015
64Insulin secretion_Homo sapiens_hsa049110.49946556
65Serotonergic synapse_Homo sapiens_hsa047260.47607822
66Histidine metabolism_Homo sapiens_hsa003400.46476472
67TNF signaling pathway_Homo sapiens_hsa046680.46255532
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46020101
69Leishmaniasis_Homo sapiens_hsa051400.42852449
70Antigen processing and presentation_Homo sapiens_hsa046120.42092339
71Spliceosome_Homo sapiens_hsa030400.41807535
72Morphine addiction_Homo sapiens_hsa050320.41018512
73Alzheimers disease_Homo sapiens_hsa050100.38915321
74Fanconi anemia pathway_Homo sapiens_hsa034600.37044542
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36267371
76Measles_Homo sapiens_hsa051620.34551022
77Mismatch repair_Homo sapiens_hsa034300.34535929
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33826898
79Staphylococcus aureus infection_Homo sapiens_hsa051500.28661385
80Olfactory transduction_Homo sapiens_hsa047400.28273971
81Huntingtons disease_Homo sapiens_hsa050160.28149759
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27383950
83Dopaminergic synapse_Homo sapiens_hsa047280.26088950
84Arachidonic acid metabolism_Homo sapiens_hsa005900.25647433
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25415166
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24597683
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23979961
88Gastric acid secretion_Homo sapiens_hsa049710.21885042
89Taste transduction_Homo sapiens_hsa047420.20839945
90Purine metabolism_Homo sapiens_hsa002300.20830537
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.20610795
92TGF-beta signaling pathway_Homo sapiens_hsa043500.20516364
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20227613
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19536689
95Cholinergic synapse_Homo sapiens_hsa047250.19340570
96Ovarian steroidogenesis_Homo sapiens_hsa049130.18692875
97VEGF signaling pathway_Homo sapiens_hsa043700.18409404
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17670843
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.17174518
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17036590

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