NPM1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.20361602
2DNA deamination (GO:0045006)4.65574962
3ribosome assembly (GO:0042255)4.23588760
4rRNA modification (GO:0000154)4.20393900
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.06771749
6exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.99631395
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.95923914
8chaperone-mediated protein transport (GO:0072321)3.93794204
9nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.89973668
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85730742
11regulation of cellular amino acid metabolic process (GO:0006521)3.85048433
12transcription elongation from RNA polymerase III promoter (GO:0006385)3.82312736
13termination of RNA polymerase III transcription (GO:0006386)3.82312736
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77427555
15ATP synthesis coupled proton transport (GO:0015986)3.77427555
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.65111601
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64463770
18rRNA methylation (GO:0031167)3.64020756
19signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.62694610
20signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.62694610
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.62694610
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.55786732
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.55786732
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53589918
25ribosomal small subunit assembly (GO:0000028)3.50809673
26positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.49274927
27signal transduction involved in DNA integrity checkpoint (GO:0072401)3.44884837
28signal transduction involved in DNA damage checkpoint (GO:0072422)3.44884837
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.44550556
30negative regulation of ligase activity (GO:0051352)3.44550556
31DNA double-strand break processing (GO:0000729)3.41813904
32signal transduction involved in cell cycle checkpoint (GO:0072395)3.40394772
33protein complex biogenesis (GO:0070271)3.35069482
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.33854805
35NADH dehydrogenase complex assembly (GO:0010257)3.33854805
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33854805
37water-soluble vitamin biosynthetic process (GO:0042364)3.33378889
38pseudouridine synthesis (GO:0001522)3.31687216
39mitochondrial respiratory chain complex assembly (GO:0033108)3.26581932
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26111398
41ribosomal large subunit biogenesis (GO:0042273)3.25111889
42protein neddylation (GO:0045116)3.25084788
43somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.24265495
44somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.24265495
45isotype switching (GO:0045190)3.24265495
46positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22919663
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.19658526
48regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.19318078
49cullin deneddylation (GO:0010388)3.18820312
50RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.16584410
51respiratory chain complex IV assembly (GO:0008535)3.15035700
52chromatin remodeling at centromere (GO:0031055)3.12049969
53CENP-A containing nucleosome assembly (GO:0034080)3.07368070
54positive regulation of ligase activity (GO:0051351)3.06997903
55positive regulation of interleukin-17 production (GO:0032740)3.06076948
56protein deneddylation (GO:0000338)3.01307187
57regulation of isotype switching to IgG isotypes (GO:0048302)3.00595493
58DNA catabolic process, exonucleolytic (GO:0000738)2.98403689
59IMP biosynthetic process (GO:0006188)2.97955850
60protein-cofactor linkage (GO:0018065)2.97910168
61regulation of chronic inflammatory response (GO:0002676)2.96486356
62cytidine metabolic process (GO:0046087)2.93916655
63cytidine catabolic process (GO:0006216)2.93916655
64cytidine deamination (GO:0009972)2.93916655
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92200551
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92200551
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88265353
68histone mRNA metabolic process (GO:0008334)2.87929445
69maturation of 5.8S rRNA (GO:0000460)2.87787084
70rRNA processing (GO:0006364)2.82007618
71positive regulation of cell cycle arrest (GO:0071158)2.81855571
72spliceosomal snRNP assembly (GO:0000387)2.80585475
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79914674
74respiratory electron transport chain (GO:0022904)2.79419433
75electron transport chain (GO:0022900)2.78983492
76regulation of cellular amine metabolic process (GO:0033238)2.78883340
77DNA damage response, detection of DNA damage (GO:0042769)2.77636048
78regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76752641
79rRNA metabolic process (GO:0016072)2.74483325
80DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.74360585
81purine nucleobase biosynthetic process (GO:0009113)2.71768930
82translation (GO:0006412)2.71495027
83ribosome biogenesis (GO:0042254)2.70232126
84DNA replication-dependent nucleosome organization (GO:0034723)2.69382345
85DNA replication-dependent nucleosome assembly (GO:0006335)2.69382345
86platelet dense granule organization (GO:0060155)2.68870760
87regulation of immunoglobulin secretion (GO:0051023)2.68595957
88tRNA processing (GO:0008033)2.67629054
89nucleobase biosynthetic process (GO:0046112)2.67277143
90GTP biosynthetic process (GO:0006183)2.66972335
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66938186
92cytochrome complex assembly (GO:0017004)2.66820190
93regulation of ubiquitin-protein transferase activity (GO:0051438)2.66763002
94tRNA metabolic process (GO:0006399)2.65160082
95protein targeting to mitochondrion (GO:0006626)2.64173875
96formation of translation preinitiation complex (GO:0001731)2.64147166
97IMP metabolic process (GO:0046040)2.63827640
98organelle disassembly (GO:1903008)2.61565596
99cellular component biogenesis (GO:0044085)2.60082648
100mitochondrial RNA metabolic process (GO:0000959)2.58169207

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.02430776
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.44541552
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.79888241
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.13521428
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07442198
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06991965
7VDR_23849224_ChIP-Seq_CD4+_Human2.95779514
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92756522
9VDR_22108803_ChIP-Seq_LS180_Human2.85763424
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.79790324
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.77990173
12ZNF274_21170338_ChIP-Seq_K562_Hela2.68161605
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62295692
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59203136
15ELK1_19687146_ChIP-ChIP_HELA_Human2.58172415
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58033248
17FOXP3_21729870_ChIP-Seq_TREG_Human2.51907241
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50250947
19E2F7_22180533_ChIP-Seq_HELA_Human2.46673497
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45061777
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26224577
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.13865331
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.96281379
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.94465373
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87240759
26EWS_26573619_Chip-Seq_HEK293_Human1.84892581
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83548897
28MYC_18940864_ChIP-ChIP_HL60_Human1.81238685
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.80500192
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74768453
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74258971
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69613793
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69398027
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68301476
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65245071
36DCP1A_22483619_ChIP-Seq_HELA_Human1.59912322
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59366565
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55694035
39FUS_26573619_Chip-Seq_HEK293_Human1.48858747
40TTF2_22483619_ChIP-Seq_HELA_Human1.48782552
41TAF15_26573619_Chip-Seq_HEK293_Human1.45214846
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42439492
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41373812
44GABP_19822575_ChIP-Seq_HepG2_Human1.39473928
45TP53_22573176_ChIP-Seq_HFKS_Human1.39378494
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38964753
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38017043
48IGF1R_20145208_ChIP-Seq_DFB_Human1.37997543
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34197419
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32499300
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31142800
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29408276
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28514108
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.28514108
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27109805
56P300_19829295_ChIP-Seq_ESCs_Human1.22411612
57NANOG_19829295_ChIP-Seq_ESCs_Human1.20832682
58SOX2_19829295_ChIP-Seq_ESCs_Human1.20832682
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20770801
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17483513
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.17426020
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17102639
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15775627
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.15106064
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.13866259
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13077096
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11883194
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11204529
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08416228
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.07409148
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07035131
72AR_20517297_ChIP-Seq_VCAP_Human1.06114608
73IRF1_19129219_ChIP-ChIP_H3396_Human1.05941137
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05813436
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05757695
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04791517
77XRN2_22483619_ChIP-Seq_HELA_Human1.04260658
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03956331
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03892178
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03476586
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03179076
82GATA3_26560356_Chip-Seq_TH2_Human1.02560579
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01136089
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99071086
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98825973
86ER_23166858_ChIP-Seq_MCF-7_Human0.98668405
87IRF8_21731497_ChIP-ChIP_J774_Mouse0.98378344
88HTT_18923047_ChIP-ChIP_STHdh_Human0.98317253
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97960706
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97623602
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97299310
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.97067961
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94228354
94ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93791341
95NCOR_22424771_ChIP-Seq_293T_Human0.93510401
96CBP_20019798_ChIP-Seq_JUKART_Human0.92445153
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92445153
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91603839
99MYB_26560356_Chip-Seq_TH2_Human0.90130086
100ERG_20517297_ChIP-Seq_VCAP_Human0.88896234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.69861171
2MP0002102_abnormal_ear_morphology2.80489132
3MP0005671_abnormal_response_to2.65857026
4MP0008058_abnormal_DNA_repair2.53368328
5MP0010094_abnormal_chromosome_stability2.42272473
6MP0006292_abnormal_olfactory_placode2.37972145
7MP0003786_premature_aging2.37327398
8MP0006072_abnormal_retinal_apoptosis2.33741384
9MP0000372_irregular_coat_pigmentation2.25521625
10MP0003718_maternal_effect2.20991522
11MP0008877_abnormal_DNA_methylation2.16112725
12MP0001873_stomach_inflammation2.15891205
13MP0003693_abnormal_embryo_hatching2.07791727
14MP0005084_abnormal_gallbladder_morpholo2.03634196
15MP0008872_abnormal_physiological_respon1.98586059
16MP0004957_abnormal_blastocyst_morpholog1.95627598
17MP0006036_abnormal_mitochondrial_physio1.94837445
18MP0003806_abnormal_nucleotide_metabolis1.91256681
19MP0008875_abnormal_xenobiotic_pharmacok1.90220260
20MP0008007_abnormal_cellular_replicative1.85172394
21MP0002837_dystrophic_cardiac_calcinosis1.77529590
22MP0003567_abnormal_fetal_cardiomyocyte1.72766591
23MP0009333_abnormal_splenocyte_physiolog1.69632098
24MP0004147_increased_porphyrin_level1.69552713
25MP0002148_abnormal_hypersensitivity_rea1.66080928
26MP0005075_abnormal_melanosome_morpholog1.64499381
27MP0003195_calcinosis1.60365321
28MP0002736_abnormal_nociception_after1.54594255
29MP0001764_abnormal_homeostasis1.51286281
30MP0009785_altered_susceptibility_to1.50171670
31MP0009697_abnormal_copulation1.49226141
32MP0003186_abnormal_redox_activity1.46348589
33MP0008057_abnormal_DNA_replication1.45743927
34MP0001529_abnormal_vocalization1.45448389
35MP0002006_tumorigenesis1.45151722
36MP0002163_abnormal_gland_morphology1.42774960
37MP0001968_abnormal_touch/_nociception1.42114812
38MP0005551_abnormal_eye_electrophysiolog1.40081073
39MP0008995_early_reproductive_senescence1.38184391
40MP0001293_anophthalmia1.37946074
41MP0004145_abnormal_muscle_electrophysio1.35653125
42MP0003077_abnormal_cell_cycle1.35123116
43MP0002166_altered_tumor_susceptibility1.34934838
44MP0000685_abnormal_immune_system1.34428007
45MP0003763_abnormal_thymus_physiology1.31393373
46MP0001800_abnormal_humoral_immune1.31158393
47MP0005645_abnormal_hypothalamus_physiol1.29682713
48MP0005389_reproductive_system_phenotype1.29404691
49MP0003646_muscle_fatigue1.27244197
50MP0005253_abnormal_eye_physiology1.26628412
51MP0001188_hyperpigmentation1.25623786
52MP0006035_abnormal_mitochondrial_morpho1.24407475
53MP0005387_immune_system_phenotype1.18172171
54MP0001790_abnormal_immune_system1.18172171
55MP0005000_abnormal_immune_tolerance1.16130112
56MP0004142_abnormal_muscle_tone1.15628873
57MP0005379_endocrine/exocrine_gland_phen1.15372084
58MP0002160_abnormal_reproductive_system1.14800456
59MP0003111_abnormal_nucleus_morphology1.13122453
60MP0003011_delayed_dark_adaptation1.09939831
61MP0000465_gastrointestinal_hemorrhage1.08876556
62MP0009379_abnormal_foot_pigmentation1.08620462
63MP0005408_hypopigmentation1.04748153
64MP0002876_abnormal_thyroid_physiology1.02580259
65MP0002723_abnormal_immune_serum0.94660533
66MP0001986_abnormal_taste_sensitivity0.93656078
67MP0001905_abnormal_dopamine_level0.91420921
68MP0001929_abnormal_gametogenesis0.89441455
69MP0001919_abnormal_reproductive_system0.89199308
70MP0002210_abnormal_sex_determination0.89131046
71MP0008789_abnormal_olfactory_epithelium0.88814616
72MP0000383_abnormal_hair_follicle0.88688180
73MP0006082_CNS_inflammation0.88068841
74MP0002398_abnormal_bone_marrow0.87110768
75MP0000689_abnormal_spleen_morphology0.86539848
76MP0002452_abnormal_antigen_presenting0.86423342
77MP0001819_abnormal_immune_cell0.86277190
78MP0006276_abnormal_autonomic_nervous0.85864394
79MP0001119_abnormal_female_reproductive0.85456022
80MP0002277_abnormal_respiratory_mucosa0.85371211
81MP0005646_abnormal_pituitary_gland0.85249833
82MP0002420_abnormal_adaptive_immunity0.85088366
83MP0000427_abnormal_hair_cycle0.83216966
84MP0005085_abnormal_gallbladder_physiolo0.82875117
85MP0004215_abnormal_myocardial_fiber0.82223719
86MP0009764_decreased_sensitivity_to0.81851720
87MP0001501_abnormal_sleep_pattern0.81661544
88MP0005410_abnormal_fertilization0.81140082
89MP0001853_heart_inflammation0.80840073
90MP0002019_abnormal_tumor_incidence0.80811552
91MP0002938_white_spotting0.80276662
92MP0004782_abnormal_surfactant_physiolog0.79802376
93MP0002095_abnormal_skin_pigmentation0.79717233
94MP0008932_abnormal_embryonic_tissue0.79664378
95MP0000653_abnormal_sex_gland0.79583003
96MP0001145_abnormal_male_reproductive0.76389768
97MP0002693_abnormal_pancreas_physiology0.73600176
98MP0005636_abnormal_mineral_homeostasis0.71655388
99MP0000716_abnormal_immune_system0.71482694
100MP0002405_respiratory_system_inflammati0.71230107

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.21142697
2Mitochondrial inheritance (HP:0001427)3.94085131
3Increased CSF lactate (HP:0002490)3.91005285
4Increased hepatocellular lipid droplets (HP:0006565)3.75188379
5Hepatocellular necrosis (HP:0001404)3.71530079
6Abnormal mitochondria in muscle tissue (HP:0008316)3.66022107
7Acute encephalopathy (HP:0006846)3.61569222
8Progressive macrocephaly (HP:0004481)3.54459597
9Lipid accumulation in hepatocytes (HP:0006561)3.33522878
10Hepatic necrosis (HP:0002605)3.33454137
11Aplastic anemia (HP:0001915)3.22149242
12Abolished electroretinogram (ERG) (HP:0000550)3.18599211
13Cerebral edema (HP:0002181)2.97911547
14Methylmalonic acidemia (HP:0002912)2.96697239
15Degeneration of anterior horn cells (HP:0002398)2.95901817
16Abnormality of the anterior horn cell (HP:0006802)2.95901817
17Increased serum lactate (HP:0002151)2.93198321
18Stomatitis (HP:0010280)2.87874328
19IgG deficiency (HP:0004315)2.78639561
203-Methylglutaconic aciduria (HP:0003535)2.78338676
21Pancreatic cysts (HP:0001737)2.77395058
22Reduced antithrombin III activity (HP:0001976)2.67190049
23Renal Fanconi syndrome (HP:0001994)2.64839885
24Congenital stationary night blindness (HP:0007642)2.60435366
25Increased intramyocellular lipid droplets (HP:0012240)2.57419636
26Decreased electroretinogram (ERG) amplitude (HP:0000654)2.54271988
27Exertional dyspnea (HP:0002875)2.48674320
28Abnormality of the prostate (HP:0008775)2.48133333
29Lactic acidosis (HP:0003128)2.47927661
30Optic disc pallor (HP:0000543)2.46467876
31Methylmalonic aciduria (HP:0012120)2.44806984
32Type I transferrin isoform profile (HP:0003642)2.44597196
33Colon cancer (HP:0003003)2.41067535
34Hypoproteinemia (HP:0003075)2.38966602
35True hermaphroditism (HP:0010459)2.37868745
36Abnormality of midbrain morphology (HP:0002418)2.37258462
37Molar tooth sign on MRI (HP:0002419)2.37258462
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36635375
39Abnormality of B cell number (HP:0010975)2.34367588
40B lymphocytopenia (HP:0010976)2.30072303
41Congenital, generalized hypertrichosis (HP:0004540)2.27744180
42Abnormality of the labia minora (HP:0012880)2.22979452
43Lethargy (HP:0001254)2.22977066
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22591201
45Hyperglycinemia (HP:0002154)2.22228095
46Severe combined immunodeficiency (HP:0004430)2.20830664
47Type 2 muscle fiber atrophy (HP:0003554)2.19812227
48Leukodystrophy (HP:0002415)2.17485811
49Decreased central vision (HP:0007663)2.17075301
50Abnormal protein glycosylation (HP:0012346)2.16182602
51Abnormal glycosylation (HP:0012345)2.16182602
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16182602
53Abnormal protein N-linked glycosylation (HP:0012347)2.16182602
54Nephronophthisis (HP:0000090)2.15644506
55Respiratory failure (HP:0002878)2.12753414
56Cerebellar dysplasia (HP:0007033)2.12257053
57Abnormality of macular pigmentation (HP:0008002)2.12025784
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11488293
59Abnormality of serum amino acid levels (HP:0003112)2.08192438
60Elevated erythrocyte sedimentation rate (HP:0003565)2.06365193
61Pancreatic fibrosis (HP:0100732)2.06255344
62Pancytopenia (HP:0001876)2.04239719
63Abnormal rod and cone electroretinograms (HP:0008323)2.03285818
64Abnormality of serine family amino acid metabolism (HP:0010894)2.02960147
65Abnormality of glycine metabolism (HP:0010895)2.02960147
66Type II lissencephaly (HP:0007260)2.01856302
67Multiple enchondromatosis (HP:0005701)2.01699952
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00344146
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99856985
70Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99856985
71Increased muscle lipid content (HP:0009058)1.98162658
72Central scotoma (HP:0000603)1.98068055
73Exercise intolerance (HP:0003546)1.95043816
74Glycosuria (HP:0003076)1.93999102
75Abnormality of urine glucose concentration (HP:0011016)1.93999102
76Constricted visual fields (HP:0001133)1.93297065
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93270027
78Abnormality of alanine metabolism (HP:0010916)1.93270027
79Hyperalaninemia (HP:0003348)1.93270027
80Panhypogammaglobulinemia (HP:0003139)1.93053183
81Dyschromatopsia (HP:0007641)1.91407539
82Thyroiditis (HP:0100646)1.90539812
83CNS demyelination (HP:0007305)1.89277463
84Abnormality of the pons (HP:0007361)1.89084542
85Respiratory difficulties (HP:0002880)1.88739261
86Abnormality of methionine metabolism (HP:0010901)1.88366247
87Abnormality of the vitamin B12 metabolism (HP:0004341)1.86890889
88Renal cortical cysts (HP:0000803)1.86528841
89Hyperglycinuria (HP:0003108)1.85975387
90Cerebral palsy (HP:0100021)1.85774271
91Hypothermia (HP:0002045)1.85739146
92Abnormality of T cells (HP:0002843)1.81736492
93Attenuation of retinal blood vessels (HP:0007843)1.81068683
94IgM deficiency (HP:0002850)1.79958060
95Abnormality of vitamin B metabolism (HP:0004340)1.78658964
96Medial flaring of the eyebrow (HP:0010747)1.78466724
97Aplasia/hypoplasia of the uterus (HP:0008684)1.78425070
98Meckel diverticulum (HP:0002245)1.77769336
99Muscle fiber atrophy (HP:0100295)1.76860948
100Oral leukoplakia (HP:0002745)1.74835510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.82360109
2ZAK3.55835928
3MST43.47155617
4VRK23.22681356
5NUAK13.01048502
6TSSK62.66788285
7PBK2.50898152
8TXK2.40102244
9VRK12.30444073
10EIF2AK12.29772789
11BUB12.23411673
12TAOK31.93849278
13ADRBK21.91658219
14CDK191.88211667
15PLK31.85362443
16BCKDK1.81910103
17GRK11.81100925
18STK161.79856872
19MAP4K21.64580467
20MKNK11.55598228
21TLK11.53780178
22WNK31.49536838
23MAP3K121.44019257
24NME11.43167657
25TRIM281.41915339
26SRPK11.40832859
27NEK11.39153033
28OXSR11.30504981
29MKNK21.30402850
30PLK41.28484701
31KDR1.25787674
32BRSK21.24187095
33CSNK1G11.20202872
34TAF11.20121514
35EIF2AK21.16511175
36CDC71.15662771
37FRK1.12786361
38ITK1.10352450
39WNK41.08037838
40DAPK11.03056038
41BMPR1B1.00330215
42PASK0.98151685
43TEC0.97744722
44BMPR20.97357063
45CSNK1G30.92193295
46WEE10.91824388
47NLK0.90404660
48TNIK0.88074745
49INSRR0.86426431
50PLK10.83146235
51TESK20.81841404
52ATR0.78061567
53SCYL20.77326771
54IKBKB0.77066371
55BCR0.76685354
56CSNK1A1L0.74730946
57PLK20.74288979
58STK390.74261997
59RPS6KA50.71686891
60CSNK1G20.71244874
61TIE10.70102912
62PINK10.69924066
63CDK30.69835855
64TTK0.69620040
65PIK3CG0.66938966
66MAP2K60.65976655
67ALK0.62519962
68PRKCQ0.57379950
69RPS6KA40.57288190
70DYRK20.56024404
71AURKB0.55164530
72KIT0.53038940
73MAP4K10.51569780
74CSNK2A10.49586102
75PRKCE0.47962869
76ERBB30.46832928
77ACVR1B0.46705014
78CSNK2A20.46192533
79MYLK0.45934624
80IKBKE0.45234098
81SYK0.44947589
82NME20.41856573
83CDK60.40161518
84CAMKK20.38016673
85LCK0.37606057
86ATM0.37074416
87MAP3K50.34630115
88GRK50.34363536
89ADRBK10.33926327
90DAPK30.32751839
91MAP3K40.32237464
92DAPK20.30892651
93LYN0.30875650
94JAK30.30851147
95CDK40.30590953
96CSNK1A10.30235979
97AURKA0.29874178
98MAPKAPK30.29809015
99FES0.28629183
100CSF1R0.27081633

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.57781747
2Protein export_Homo sapiens_hsa030603.06890095
3Asthma_Homo sapiens_hsa053103.03845820
4Allograft rejection_Homo sapiens_hsa053302.80933235
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66108071
6RNA polymerase_Homo sapiens_hsa030202.61833561
7Autoimmune thyroid disease_Homo sapiens_hsa053202.61339439
8Oxidative phosphorylation_Homo sapiens_hsa001902.54984925
9Type I diabetes mellitus_Homo sapiens_hsa049402.32848032
10Ribosome_Homo sapiens_hsa030102.28322201
11Graft-versus-host disease_Homo sapiens_hsa053322.26107402
12Mismatch repair_Homo sapiens_hsa034302.20910151
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.18742511
14Parkinsons disease_Homo sapiens_hsa050122.16428768
15RNA degradation_Homo sapiens_hsa030181.96886687
16Homologous recombination_Homo sapiens_hsa034401.92646815
17DNA replication_Homo sapiens_hsa030301.89403396
18One carbon pool by folate_Homo sapiens_hsa006701.85231731
19Primary immunodeficiency_Homo sapiens_hsa053401.82877762
20RNA transport_Homo sapiens_hsa030131.70612582
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65856277
22Propanoate metabolism_Homo sapiens_hsa006401.62915653
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61259449
24Basal transcription factors_Homo sapiens_hsa030221.59545130
25Non-homologous end-joining_Homo sapiens_hsa034501.56060064
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53125395
27Nucleotide excision repair_Homo sapiens_hsa034201.51583164
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51442764
29Antigen processing and presentation_Homo sapiens_hsa046121.48955731
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47898351
31Huntingtons disease_Homo sapiens_hsa050161.38305523
32Spliceosome_Homo sapiens_hsa030401.37853962
33Fanconi anemia pathway_Homo sapiens_hsa034601.37361485
34Pyrimidine metabolism_Homo sapiens_hsa002401.33662190
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25056894
36Alzheimers disease_Homo sapiens_hsa050101.24894518
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18999105
38Rheumatoid arthritis_Homo sapiens_hsa053231.18938916
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.16555051
40Phototransduction_Homo sapiens_hsa047441.13723280
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13483102
42Purine metabolism_Homo sapiens_hsa002301.11499857
43Base excision repair_Homo sapiens_hsa034101.11227728
44Selenocompound metabolism_Homo sapiens_hsa004501.03715330
45Linoleic acid metabolism_Homo sapiens_hsa005911.02132714
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97162637
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92439421
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90500392
49Systemic lupus erythematosus_Homo sapiens_hsa053220.85301128
50Peroxisome_Homo sapiens_hsa041460.82217971
51Regulation of autophagy_Homo sapiens_hsa041400.81589220
52Butanoate metabolism_Homo sapiens_hsa006500.79485957
53Tryptophan metabolism_Homo sapiens_hsa003800.79077632
54Viral myocarditis_Homo sapiens_hsa054160.73823886
55Fatty acid elongation_Homo sapiens_hsa000620.72868954
56Hematopoietic cell lineage_Homo sapiens_hsa046400.72080946
57Glutathione metabolism_Homo sapiens_hsa004800.71707251
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70588159
59Caffeine metabolism_Homo sapiens_hsa002320.69916740
60Nitrogen metabolism_Homo sapiens_hsa009100.66116118
61Vitamin B6 metabolism_Homo sapiens_hsa007500.64662568
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64510357
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62266341
64Sulfur metabolism_Homo sapiens_hsa009200.60907371
65Arachidonic acid metabolism_Homo sapiens_hsa005900.59861982
66Cardiac muscle contraction_Homo sapiens_hsa042600.58751720
67Ether lipid metabolism_Homo sapiens_hsa005650.58157404
68Pyruvate metabolism_Homo sapiens_hsa006200.54076090
69Metabolic pathways_Homo sapiens_hsa011000.53181023
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52429354
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51916073
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51170242
73Steroid biosynthesis_Homo sapiens_hsa001000.50665156
74Retinol metabolism_Homo sapiens_hsa008300.50110746
75Epstein-Barr virus infection_Homo sapiens_hsa051690.48243746
76Olfactory transduction_Homo sapiens_hsa047400.46911800
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45939537
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42926965
79Cell cycle_Homo sapiens_hsa041100.41991769
80mRNA surveillance pathway_Homo sapiens_hsa030150.41808329
81Chemical carcinogenesis_Homo sapiens_hsa052040.41661827
82p53 signaling pathway_Homo sapiens_hsa041150.41245280
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40070934
84Collecting duct acid secretion_Homo sapiens_hsa049660.38614787
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.36925204
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35482927
87Herpes simplex infection_Homo sapiens_hsa051680.34897506
88beta-Alanine metabolism_Homo sapiens_hsa004100.34655678
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.34353874
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33069659
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.30432880
92Measles_Homo sapiens_hsa051620.30124138
93Carbon metabolism_Homo sapiens_hsa012000.29825662
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28351747
95T cell receptor signaling pathway_Homo sapiens_hsa046600.27897016
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26687774
97Staphylococcus aureus infection_Homo sapiens_hsa051500.23272150
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22937247
99Fatty acid degradation_Homo sapiens_hsa000710.21484946
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21314402

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