NPM1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.77335598
2proteasome assembly (GO:0043248)5.52737652
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.52660331
4chaperone-mediated protein transport (GO:0072321)4.32439121
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.19873457
6cytidine deamination (GO:0009972)4.09544944
7cytidine metabolic process (GO:0046087)4.09544944
8cytidine catabolic process (GO:0006216)4.09544944
9protein neddylation (GO:0045116)4.04906878
10rRNA modification (GO:0000154)4.04802847
11protein deneddylation (GO:0000338)3.96726140
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96247722
13positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.89101885
14cullin deneddylation (GO:0010388)3.85405112
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76727546
16ATP synthesis coupled proton transport (GO:0015986)3.76727546
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74466309
18nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.69270372
19protein K6-linked ubiquitination (GO:0085020)3.65926658
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61964076
21regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.61336242
22pseudouridine synthesis (GO:0001522)3.59734325
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58585763
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.58585763
25NADH dehydrogenase complex assembly (GO:0010257)3.58585763
26ribosomal small subunit assembly (GO:0000028)3.55328140
27protein complex biogenesis (GO:0070271)3.55074106
28rRNA methylation (GO:0031167)3.54475321
29regulation of cellular amino acid metabolic process (GO:0006521)3.54160137
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53962142
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53962142
32regulation of regulatory T cell differentiation (GO:0045589)3.53188784
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.50166312
34ribosome assembly (GO:0042255)3.49995271
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49393528
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.46496871
37signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.46496871
38signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.46496871
39regulation of isotype switching to IgG isotypes (GO:0048302)3.44726803
40mitochondrial respiratory chain complex assembly (GO:0033108)3.43388166
41intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40290823
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40290823
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38252808
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36254333
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.30503039
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.30503039
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29438475
48negative regulation of ligase activity (GO:0051352)3.29438475
49pyrimidine ribonucleoside catabolic process (GO:0046133)3.27716679
50regulation of skeletal muscle contraction (GO:0014819)3.26703176
51termination of RNA polymerase III transcription (GO:0006386)3.26297496
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.26297496
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.24459631
54negative regulation of DNA-dependent DNA replication (GO:2000104)3.20720912
55somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.17521093
56somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.17521093
57isotype switching (GO:0045190)3.17521093
58regulation of immunoglobulin secretion (GO:0051023)3.15440642
59water-soluble vitamin biosynthetic process (GO:0042364)3.12704508
60RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10823414
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09606481
62DNA catabolic process, exonucleolytic (GO:0000738)3.07726413
63GTP biosynthetic process (GO:0006183)3.06428861
64rRNA processing (GO:0006364)2.97790933
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95969618
66ribosomal large subunit biogenesis (GO:0042273)2.93372409
67DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.89641907
68DNA double-strand break processing (GO:0000729)2.89260015
69regulation of DNA endoreduplication (GO:0032875)2.89144025
70rRNA metabolic process (GO:0016072)2.88477040
71positive regulation of ligase activity (GO:0051351)2.83635419
72CENP-A containing nucleosome assembly (GO:0034080)2.78572159
73chromatin remodeling at centromere (GO:0031055)2.78451108
74intra-S DNA damage checkpoint (GO:0031573)2.77858268
75respiratory electron transport chain (GO:0022904)2.76711357
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75466271
77translation (GO:0006412)2.74170994
78positive regulation of cell cycle arrest (GO:0071158)2.73819364
79electron transport chain (GO:0022900)2.73269814
80intracellular protein transmembrane import (GO:0044743)2.71441556
81transcription from mitochondrial promoter (GO:0006390)2.70865850
82tRNA processing (GO:0008033)2.66386412
83protein polyglutamylation (GO:0018095)2.65950669
84preassembly of GPI anchor in ER membrane (GO:0016254)2.65764445
85mitochondrial RNA metabolic process (GO:0000959)2.65042197
86termination of RNA polymerase I transcription (GO:0006363)2.63955746
87response to pheromone (GO:0019236)2.62822668
88maturation of SSU-rRNA (GO:0030490)2.62276294
89tRNA metabolic process (GO:0006399)2.62218621
90regulation of chronic inflammatory response (GO:0002676)2.61781925
91postreplication repair (GO:0006301)2.61034822
92formation of translation preinitiation complex (GO:0001731)2.60951858
93protein targeting to mitochondrion (GO:0006626)2.59908956
94pyrimidine ribonucleoside metabolic process (GO:0046131)2.58228568
95UTP biosynthetic process (GO:0006228)2.57037114
96protein-cofactor linkage (GO:0018065)2.56161894
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.55101418
98organelle disassembly (GO:1903008)2.54594407
99cellular component biogenesis (GO:0044085)2.54010608
100ncRNA metabolic process (GO:0034660)2.53730749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.90176493
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42403251
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.89340559
4VDR_22108803_ChIP-Seq_LS180_Human3.75147566
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.60755713
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.21888112
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91800381
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.74655601
9VDR_23849224_ChIP-Seq_CD4+_Human2.63691540
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57336592
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49592848
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41799887
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.40093774
14TAF15_26573619_Chip-Seq_HEK293_Human2.39485801
15ELK1_19687146_ChIP-ChIP_HELA_Human2.35914243
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34469305
17EWS_26573619_Chip-Seq_HEK293_Human2.32480265
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.28306542
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23572918
20FUS_26573619_Chip-Seq_HEK293_Human2.21368338
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16468976
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11207240
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09424117
24FOXP3_21729870_ChIP-Seq_TREG_Human2.02480906
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93902708
26E2F7_22180533_ChIP-Seq_HELA_Human1.93812494
27ZNF274_21170338_ChIP-Seq_K562_Hela1.88949497
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77067984
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.69550027
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64953501
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64694589
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.64160603
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61992548
34MYC_18940864_ChIP-ChIP_HL60_Human1.61275711
35IGF1R_20145208_ChIP-Seq_DFB_Human1.59678548
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59414919
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51293577
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48965026
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48957687
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48037789
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44792138
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42071447
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39164060
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39050121
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38340798
46P300_19829295_ChIP-Seq_ESCs_Human1.37261767
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35297939
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34894061
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34485876
50GATA1_22025678_ChIP-Seq_K562_Human1.32586826
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31548232
52ER_23166858_ChIP-Seq_MCF-7_Human1.31354554
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.28732272
54TTF2_22483619_ChIP-Seq_HELA_Human1.28441977
55DCP1A_22483619_ChIP-Seq_HELA_Human1.28294387
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28258811
57TP53_22573176_ChIP-Seq_HFKS_Human1.24250383
58NANOG_19829295_ChIP-Seq_ESCs_Human1.23682618
59SOX2_19829295_ChIP-Seq_ESCs_Human1.23682618
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19862995
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.17915614
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14524571
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13171980
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12263661
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11422291
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10645506
67CBP_20019798_ChIP-Seq_JUKART_Human1.10645506
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10268754
69GATA3_26560356_Chip-Seq_TH2_Human1.08047802
70MYB_26560356_Chip-Seq_TH2_Human1.06361163
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05852267
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.05804467
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05804467
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05702679
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04218658
76AR_20517297_ChIP-Seq_VCAP_Human1.02271504
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02201337
78POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99917222
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98456855
80BP1_19119308_ChIP-ChIP_Hs578T_Human0.97665419
81E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97497803
82YY1_21170310_ChIP-Seq_MESCs_Mouse0.96044434
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94022612
84CRX_20693478_ChIP-Seq_RETINA_Mouse0.92945566
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91946320
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91940339
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90800318
88NCOR_22424771_ChIP-Seq_293T_Human0.90668757
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90229916
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89469887
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88731386
92GABP_19822575_ChIP-Seq_HepG2_Human0.88489460
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87156651
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86129850
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85639530
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84945062
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84783139
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84551292
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83794414
100P53_22387025_ChIP-Seq_ESCs_Mouse0.83321345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.13816217
2MP0004145_abnormal_muscle_electrophysio2.98506724
3MP0001835_abnormal_antigen_presentation2.92408012
4MP0008877_abnormal_DNA_methylation2.88460393
5MP0008057_abnormal_DNA_replication2.87184134
6MP0006292_abnormal_olfactory_placode2.67245513
7MP0003718_maternal_effect2.60735021
8MP0003646_muscle_fatigue2.43953064
9MP0006072_abnormal_retinal_apoptosis2.37385430
10MP0004147_increased_porphyrin_level2.36346637
11MP0008058_abnormal_DNA_repair2.23968184
12MP0005671_abnormal_response_to2.17481242
13MP0010094_abnormal_chromosome_stability2.16126257
14MP0002102_abnormal_ear_morphology2.15448963
15MP0004957_abnormal_blastocyst_morpholog2.09576682
16MP0002837_dystrophic_cardiac_calcinosis2.09054994
17MP0003786_premature_aging2.06952334
18MP0005084_abnormal_gallbladder_morpholo1.93015505
19MP0001188_hyperpigmentation1.90702563
20MP0001873_stomach_inflammation1.87303483
21MP0000685_abnormal_immune_system1.81252193
22MP0004215_abnormal_myocardial_fiber1.78347352
23MP0008872_abnormal_physiological_respon1.75014824
24MP0000372_irregular_coat_pigmentation1.69178899
25MP0005646_abnormal_pituitary_gland1.67730411
26MP0004885_abnormal_endolymph1.63312660
27MP0006036_abnormal_mitochondrial_physio1.58698358
28MP0003693_abnormal_embryo_hatching1.51583772
29MP0001529_abnormal_vocalization1.41971978
30MP0003806_abnormal_nucleotide_metabolis1.39611854
31MP0002876_abnormal_thyroid_physiology1.38395158
32MP0009333_abnormal_splenocyte_physiolog1.37258291
33MP0001968_abnormal_touch/_nociception1.36394743
34MP0004036_abnormal_muscle_relaxation1.36173981
35MP0008007_abnormal_cellular_replicative1.35945600
36MP0000749_muscle_degeneration1.32287018
37MP0003077_abnormal_cell_cycle1.31682162
38MP0003567_abnormal_fetal_cardiomyocyte1.30983191
39MP0006035_abnormal_mitochondrial_morpho1.28880673
40MP0002277_abnormal_respiratory_mucosa1.28315644
41MP0004142_abnormal_muscle_tone1.25687500
42MP0002006_tumorigenesis1.23795241
43MP0002148_abnormal_hypersensitivity_rea1.23740537
44MP0005253_abnormal_eye_physiology1.23658149
45MP0003950_abnormal_plasma_membrane1.22844338
46MP0003195_calcinosis1.21436163
47MP0002736_abnormal_nociception_after1.19940486
48MP0009379_abnormal_foot_pigmentation1.19213620
49MP0005551_abnormal_eye_electrophysiolog1.16818879
50MP0001800_abnormal_humoral_immune1.16098453
51MP0000631_abnormal_neuroendocrine_gland1.15644737
52MP0003011_delayed_dark_adaptation1.14804898
53MP0002166_altered_tumor_susceptibility1.12913584
54MP0002163_abnormal_gland_morphology1.11878991
55MP0005389_reproductive_system_phenotype1.11775725
56MP0000465_gastrointestinal_hemorrhage1.09035997
57MP0005645_abnormal_hypothalamus_physiol1.08359886
58MP0009697_abnormal_copulation1.08215590
59MP0010368_abnormal_lymphatic_system1.08161590
60MP0004134_abnormal_chest_morphology1.05850470
61MP0001661_extended_life_span1.01575764
62MP0008875_abnormal_xenobiotic_pharmacok0.99113123
63MP0005387_immune_system_phenotype0.97157824
64MP0001790_abnormal_immune_system0.97157824
65MP0009764_decreased_sensitivity_to0.96299087
66MP0003763_abnormal_thymus_physiology0.96192993
67MP0002160_abnormal_reproductive_system0.95511998
68MP0009250_abnormal_appendicular_skeleto0.94634681
69MP0001485_abnormal_pinna_reflex0.94490810
70MP0005360_urolithiasis0.93354139
71MP0002269_muscular_atrophy0.93135150
72MP0001293_anophthalmia0.92795494
73MP0003111_abnormal_nucleus_morphology0.92447596
74MP0000689_abnormal_spleen_morphology0.92318232
75MP0009785_altered_susceptibility_to0.91836631
76MP0002398_abnormal_bone_marrow0.91099435
77MP0005379_endocrine/exocrine_gland_phen0.90778129
78MP0005636_abnormal_mineral_homeostasis0.89651954
79MP0000703_abnormal_thymus_morphology0.88476783
80MP0002396_abnormal_hematopoietic_system0.87461396
81MP0000747_muscle_weakness0.86513270
82MP0008995_early_reproductive_senescence0.85949732
83MP0003186_abnormal_redox_activity0.84818551
84MP0003866_abnormal_defecation0.83957887
85MP0005000_abnormal_immune_tolerance0.82499176
86MP0002106_abnormal_muscle_physiology0.81248425
87MP0001986_abnormal_taste_sensitivity0.80923435
88MP0002723_abnormal_immune_serum0.80138530
89MP0001919_abnormal_reproductive_system0.78476523
90MP0002019_abnormal_tumor_incidence0.77960236
91MP0001119_abnormal_female_reproductive0.77055184
92MP0002722_abnormal_immune_system0.76574388
93MP0002095_abnormal_skin_pigmentation0.75745365
94MP0004084_abnormal_cardiac_muscle0.75564073
95MP0002420_abnormal_adaptive_immunity0.74973093
96MP0003252_abnormal_bile_duct0.74521507
97MP0002210_abnormal_sex_determination0.74031126
98MP0001853_heart_inflammation0.74014840
99MP0000716_abnormal_immune_system0.73852039
100MP0002127_abnormal_cardiovascular_syste0.73310632

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.00557014
2Increased CSF lactate (HP:0002490)3.85410616
3Mitochondrial inheritance (HP:0001427)3.81653171
4Hepatocellular necrosis (HP:0001404)3.65781064
5Acute encephalopathy (HP:0006846)3.43574145
6Abnormal mitochondria in muscle tissue (HP:0008316)3.41864429
7Hepatic necrosis (HP:0002605)3.35048285
8Progressive macrocephaly (HP:0004481)3.31062108
93-Methylglutaconic aciduria (HP:0003535)3.26347095
10Reduced antithrombin III activity (HP:0001976)3.24811458
11IgG deficiency (HP:0004315)3.07059232
12Congenital stationary night blindness (HP:0007642)3.03430686
13Increased hepatocellular lipid droplets (HP:0006565)3.02734656
14Nemaline bodies (HP:0003798)2.91589141
15Pancreatic cysts (HP:0001737)2.84870406
16Increased serum lactate (HP:0002151)2.83469366
17Lipid accumulation in hepatocytes (HP:0006561)2.79878358
18Cerebral edema (HP:0002181)2.69410544
19Abnormality of the phalanges of the 2nd finger (HP:0009541)2.65896842
20B lymphocytopenia (HP:0010976)2.65667723
21Stomatitis (HP:0010280)2.61149773
22Decreased central vision (HP:0007663)2.60819360
23Abnormality of the pons (HP:0007361)2.57050697
24Abnormality of B cell number (HP:0010975)2.56923221
25Colon cancer (HP:0003003)2.54111375
26Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43211194
27Decreased electroretinogram (ERG) amplitude (HP:0000654)2.41827767
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.40824293
29Muscle fiber inclusion bodies (HP:0100299)2.39191955
30Abnormality of the ileum (HP:0001549)2.36227750
31Exertional dyspnea (HP:0002875)2.34926877
32Abolished electroretinogram (ERG) (HP:0000550)2.34255595
33Aplastic anemia (HP:0001915)2.32624816
34Aplasia/hypoplasia of the uterus (HP:0008684)2.31907820
35Methylmalonic acidemia (HP:0002912)2.31255154
36Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.29568366
37Lactic acidosis (HP:0003128)2.28410321
38Type I transferrin isoform profile (HP:0003642)2.28244357
39Congenital, generalized hypertrichosis (HP:0004540)2.28079729
40Meckel diverticulum (HP:0002245)2.26001591
41Hypoplasia of the pons (HP:0012110)2.25187705
42Optic disc pallor (HP:0000543)2.23035313
43Type II lissencephaly (HP:0007260)2.20457076
44Fibular aplasia (HP:0002990)2.19992238
45Exercise intolerance (HP:0003546)2.18193215
46Autoimmune hemolytic anemia (HP:0001890)2.17727066
47Type 2 muscle fiber atrophy (HP:0003554)2.15741446
48Absent phalangeal crease (HP:0006109)2.14975719
49Abnormality of macular pigmentation (HP:0008002)2.13836168
50Short tibia (HP:0005736)2.13475553
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11235261
52Hypoproteinemia (HP:0003075)2.11056224
53Abnormality of the phalanges of the 5th finger (HP:0004213)2.07612332
54Supernumerary spleens (HP:0009799)2.06797340
55Abnormality of midbrain morphology (HP:0002418)2.06616533
56Molar tooth sign on MRI (HP:0002419)2.06616533
57Abnormality of alanine metabolism (HP:0010916)2.05369352
58Hyperalaninemia (HP:0003348)2.05369352
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05369352
60Respiratory failure (HP:0002878)2.05118925
61Abnormal finger flexion creases (HP:0006143)2.03433579
62Renal Fanconi syndrome (HP:0001994)2.02149097
63Hyperglycinemia (HP:0002154)2.01006049
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00050394
65Microvesicular hepatic steatosis (HP:0001414)1.98262549
66Methylmalonic aciduria (HP:0012120)1.98124543
67Abnormal glycosylation (HP:0012345)1.97097610
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97097610
69Abnormal protein N-linked glycosylation (HP:0012347)1.97097610
70Abnormal protein glycosylation (HP:0012346)1.97097610
71Conjunctival hamartoma (HP:0100780)1.95818465
72Palpebral edema (HP:0100540)1.93590898
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.92323098
74Clubbing of toes (HP:0100760)1.88582896
75Abnormal rod and cone electroretinograms (HP:0008323)1.88405780
76Oral leukoplakia (HP:0002745)1.88124884
77Increased IgM level (HP:0003496)1.87636709
78Abnormality of serum amino acid levels (HP:0003112)1.86325709
79Chronic sinusitis (HP:0011109)1.85101108
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.84344005
81Leukodystrophy (HP:0002415)1.82598789
82Abnormality of T cell physiology (HP:0011840)1.82461913
83Elevated erythrocyte sedimentation rate (HP:0003565)1.81742805
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81635172
85Abnormality of the renal cortex (HP:0011035)1.80722680
86CNS demyelination (HP:0007305)1.80010026
87Abnormality of the prostate (HP:0008775)1.78672222
88Abnormality of chromosome stability (HP:0003220)1.78134250
89Nephronophthisis (HP:0000090)1.77690873
90Pendular nystagmus (HP:0012043)1.74647252
91Abnormality of the renal collecting system (HP:0004742)1.74378700
92Lethargy (HP:0001254)1.74186606
93Pancreatic fibrosis (HP:0100732)1.73767858
94Distal arthrogryposis (HP:0005684)1.73115212
95IgM deficiency (HP:0002850)1.72287762
96Muscle hypertrophy of the lower extremities (HP:0008968)1.71936799
97Thyroiditis (HP:0100646)1.70771149
98Delayed CNS myelination (HP:0002188)1.69842310
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.69603129
100Increased corneal curvature (HP:0100692)1.68292620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.24946342
2MST43.03619322
3NUAK12.86844114
4ZAK2.84519820
5TIE12.82321084
6TAOK32.76368208
7TXK2.75661831
8VRK22.74624571
9BUB12.27771714
10STK162.21135812
11EIF2AK12.18004717
12TLK12.15068410
13OBSCN2.13909988
14BCKDK2.06570780
15TNIK2.01593803
16TSSK62.01365991
17MKNK21.95103693
18GRK11.94665322
19NME21.87040593
20PBK1.82343972
21SRPK11.77136018
22MKNK11.74197986
23PHKG21.73527786
24PHKG11.73527786
25BMPR1B1.72958124
26TEC1.68437631
27VRK11.66602244
28TAF11.60706595
29PLK31.57248970
30MAP3K121.53271912
31NME11.41579158
32MAP4K21.34622043
33EIF2AK21.34282038
34PLK41.31934836
35PINK11.30581856
36ADRBK21.30188806
37FRK1.19990382
38OXSR11.17338238
39TRIM281.13821218
40WNK41.13006037
41WNK31.12848699
42ITK1.10450934
43NEK11.04464514
44CSNK1A1L1.00004808
45ACVR1B0.92965588
46CSNK1G30.90049327
47TESK20.88796565
48DAPK10.88024203
49CSNK1G10.83643926
50MAP2K60.83233125
51STK390.78907511
52CDK190.75223702
53ATR0.74719302
54PLK10.73148276
55NLK0.71942816
56MYLK0.71541421
57JAK30.70382769
58KDR0.69205066
59TGFBR10.66305446
60TTK0.64522539
61CDC70.62708651
62KIT0.62350191
63PASK0.62334219
64FLT30.61926708
65STK30.57890864
66CSNK1G20.56907038
67ERBB30.56332620
68DYRK20.55988528
69ALK0.55965643
70CHEK20.55315802
71MAP3K130.52641808
72IKBKB0.52588080
73PRKCQ0.52100551
74STK38L0.50932171
75INSRR0.46032559
76BTK0.45752910
77CSNK2A10.45327445
78BCR0.45256179
79AURKB0.45137098
80PLK20.44711940
81CCNB10.44318799
82RPS6KA50.42827208
83DAPK20.42682251
84SCYL20.40684068
85ATM0.39344245
86AKT30.38887619
87WNK10.38563083
88CSNK2A20.38321071
89NEK20.37142675
90PRKCE0.36196677
91GRK60.35611159
92SYK0.35089367
93RPS6KA40.34687965
94IGF1R0.32812062
95LCK0.32505676
96PRKG10.28445813
97MAP4K10.27614516
98MAP3K140.26076443
99FGFR10.25598590
100PRKACA0.24405583

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.01849846
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98298584
3Asthma_Homo sapiens_hsa053102.97678081
4Ribosome_Homo sapiens_hsa030102.96442183
5Protein export_Homo sapiens_hsa030602.96104663
6RNA polymerase_Homo sapiens_hsa030202.88275504
7Oxidative phosphorylation_Homo sapiens_hsa001902.73841308
8Homologous recombination_Homo sapiens_hsa034402.32238839
9Parkinsons disease_Homo sapiens_hsa050122.30384561
10Autoimmune thyroid disease_Homo sapiens_hsa053202.21459065
11Allograft rejection_Homo sapiens_hsa053302.20859541
12Mismatch repair_Homo sapiens_hsa034302.20143190
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.15227706
14RNA degradation_Homo sapiens_hsa030181.97731572
15Primary immunodeficiency_Homo sapiens_hsa053401.94798763
16Basal transcription factors_Homo sapiens_hsa030221.90087595
17DNA replication_Homo sapiens_hsa030301.85650933
18One carbon pool by folate_Homo sapiens_hsa006701.82562897
19Nucleotide excision repair_Homo sapiens_hsa034201.78619136
20RNA transport_Homo sapiens_hsa030131.73921816
21Propanoate metabolism_Homo sapiens_hsa006401.72091190
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71219584
23Spliceosome_Homo sapiens_hsa030401.66984415
24Type I diabetes mellitus_Homo sapiens_hsa049401.62020127
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61839781
26Graft-versus-host disease_Homo sapiens_hsa053321.59927636
27Pyrimidine metabolism_Homo sapiens_hsa002401.56090513
28Huntingtons disease_Homo sapiens_hsa050161.54781033
29Fanconi anemia pathway_Homo sapiens_hsa034601.48423889
30Non-homologous end-joining_Homo sapiens_hsa034501.42758251
31Alzheimers disease_Homo sapiens_hsa050101.42683620
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42542463
33Base excision repair_Homo sapiens_hsa034101.34096692
34Purine metabolism_Homo sapiens_hsa002301.29534269
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.23935842
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15967525
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11234515
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09271071
39Cardiac muscle contraction_Homo sapiens_hsa042601.08531410
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03773565
41Phototransduction_Homo sapiens_hsa047441.03050338
42Antigen processing and presentation_Homo sapiens_hsa046120.98677478
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97733214
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93317364
45Selenocompound metabolism_Homo sapiens_hsa004500.88215214
46Nitrogen metabolism_Homo sapiens_hsa009100.81332396
47Peroxisome_Homo sapiens_hsa041460.79669774
48Hematopoietic cell lineage_Homo sapiens_hsa046400.78629433
49Rheumatoid arthritis_Homo sapiens_hsa053230.77836430
50Sulfur metabolism_Homo sapiens_hsa009200.77535523
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77524036
52Linoleic acid metabolism_Homo sapiens_hsa005910.74585786
53mRNA surveillance pathway_Homo sapiens_hsa030150.68930380
54Olfactory transduction_Homo sapiens_hsa047400.67872978
55Tryptophan metabolism_Homo sapiens_hsa003800.66204328
56Regulation of autophagy_Homo sapiens_hsa041400.65796571
57Caffeine metabolism_Homo sapiens_hsa002320.63320700
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62361014
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61210143
60T cell receptor signaling pathway_Homo sapiens_hsa046600.58169209
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57842130
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.57048324
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56588515
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55704528
65Glutathione metabolism_Homo sapiens_hsa004800.54677359
66Epstein-Barr virus infection_Homo sapiens_hsa051690.53865858
67Retinol metabolism_Homo sapiens_hsa008300.51728223
68Viral myocarditis_Homo sapiens_hsa054160.50843397
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50596356
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49581469
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.49318612
72Metabolic pathways_Homo sapiens_hsa011000.49275180
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.48877265
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.48391173
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47920422
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47807485
77Systemic lupus erythematosus_Homo sapiens_hsa053220.47551038
78Pyruvate metabolism_Homo sapiens_hsa006200.47271444
79Butanoate metabolism_Homo sapiens_hsa006500.44843108
80Chemical carcinogenesis_Homo sapiens_hsa052040.44205148
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44168968
82Arachidonic acid metabolism_Homo sapiens_hsa005900.42448984
83Measles_Homo sapiens_hsa051620.42321158
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41992760
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40882723
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40702347
87Cell cycle_Homo sapiens_hsa041100.38802523
88Herpes simplex infection_Homo sapiens_hsa051680.34658988
89Fatty acid elongation_Homo sapiens_hsa000620.32737444
90Oocyte meiosis_Homo sapiens_hsa041140.32473684
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32142164
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32039793
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30986191
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28662355
95Folate biosynthesis_Homo sapiens_hsa007900.27052778
96beta-Alanine metabolism_Homo sapiens_hsa004100.23523733
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.22601505
98p53 signaling pathway_Homo sapiens_hsa041150.21693676
99Carbon metabolism_Homo sapiens_hsa012000.20611619
100Fatty acid degradation_Homo sapiens_hsa000710.20102296

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