

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.77335598 |
| 2 | proteasome assembly (GO:0043248) | 5.52737652 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.52660331 |
| 4 | chaperone-mediated protein transport (GO:0072321) | 4.32439121 |
| 5 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.19873457 |
| 6 | cytidine deamination (GO:0009972) | 4.09544944 |
| 7 | cytidine metabolic process (GO:0046087) | 4.09544944 |
| 8 | cytidine catabolic process (GO:0006216) | 4.09544944 |
| 9 | protein neddylation (GO:0045116) | 4.04906878 |
| 10 | rRNA modification (GO:0000154) | 4.04802847 |
| 11 | protein deneddylation (GO:0000338) | 3.96726140 |
| 12 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.96247722 |
| 13 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.89101885 |
| 14 | cullin deneddylation (GO:0010388) | 3.85405112 |
| 15 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.76727546 |
| 16 | ATP synthesis coupled proton transport (GO:0015986) | 3.76727546 |
| 17 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.74466309 |
| 18 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.69270372 |
| 19 | protein K6-linked ubiquitination (GO:0085020) | 3.65926658 |
| 20 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.61964076 |
| 21 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.61336242 |
| 22 | pseudouridine synthesis (GO:0001522) | 3.59734325 |
| 23 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.58585763 |
| 24 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.58585763 |
| 25 | NADH dehydrogenase complex assembly (GO:0010257) | 3.58585763 |
| 26 | ribosomal small subunit assembly (GO:0000028) | 3.55328140 |
| 27 | protein complex biogenesis (GO:0070271) | 3.55074106 |
| 28 | rRNA methylation (GO:0031167) | 3.54475321 |
| 29 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.54160137 |
| 30 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.53962142 |
| 31 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.53962142 |
| 32 | regulation of regulatory T cell differentiation (GO:0045589) | 3.53188784 |
| 33 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.50166312 |
| 34 | ribosome assembly (GO:0042255) | 3.49995271 |
| 35 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.49393528 |
| 36 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.46496871 |
| 37 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.46496871 |
| 38 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.46496871 |
| 39 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.44726803 |
| 40 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.43388166 |
| 41 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.40290823 |
| 42 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.40290823 |
| 43 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.38252808 |
| 44 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.36254333 |
| 45 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.30503039 |
| 46 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.30503039 |
| 47 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.29438475 |
| 48 | negative regulation of ligase activity (GO:0051352) | 3.29438475 |
| 49 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.27716679 |
| 50 | regulation of skeletal muscle contraction (GO:0014819) | 3.26703176 |
| 51 | termination of RNA polymerase III transcription (GO:0006386) | 3.26297496 |
| 52 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.26297496 |
| 53 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.24459631 |
| 54 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.20720912 |
| 55 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.17521093 |
| 56 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.17521093 |
| 57 | isotype switching (GO:0045190) | 3.17521093 |
| 58 | regulation of immunoglobulin secretion (GO:0051023) | 3.15440642 |
| 59 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.12704508 |
| 60 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.10823414 |
| 61 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.09606481 |
| 62 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.07726413 |
| 63 | GTP biosynthetic process (GO:0006183) | 3.06428861 |
| 64 | rRNA processing (GO:0006364) | 2.97790933 |
| 65 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.95969618 |
| 66 | ribosomal large subunit biogenesis (GO:0042273) | 2.93372409 |
| 67 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.89641907 |
| 68 | DNA double-strand break processing (GO:0000729) | 2.89260015 |
| 69 | regulation of DNA endoreduplication (GO:0032875) | 2.89144025 |
| 70 | rRNA metabolic process (GO:0016072) | 2.88477040 |
| 71 | positive regulation of ligase activity (GO:0051351) | 2.83635419 |
| 72 | CENP-A containing nucleosome assembly (GO:0034080) | 2.78572159 |
| 73 | chromatin remodeling at centromere (GO:0031055) | 2.78451108 |
| 74 | intra-S DNA damage checkpoint (GO:0031573) | 2.77858268 |
| 75 | respiratory electron transport chain (GO:0022904) | 2.76711357 |
| 76 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.75466271 |
| 77 | translation (GO:0006412) | 2.74170994 |
| 78 | positive regulation of cell cycle arrest (GO:0071158) | 2.73819364 |
| 79 | electron transport chain (GO:0022900) | 2.73269814 |
| 80 | intracellular protein transmembrane import (GO:0044743) | 2.71441556 |
| 81 | transcription from mitochondrial promoter (GO:0006390) | 2.70865850 |
| 82 | tRNA processing (GO:0008033) | 2.66386412 |
| 83 | protein polyglutamylation (GO:0018095) | 2.65950669 |
| 84 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.65764445 |
| 85 | mitochondrial RNA metabolic process (GO:0000959) | 2.65042197 |
| 86 | termination of RNA polymerase I transcription (GO:0006363) | 2.63955746 |
| 87 | response to pheromone (GO:0019236) | 2.62822668 |
| 88 | maturation of SSU-rRNA (GO:0030490) | 2.62276294 |
| 89 | tRNA metabolic process (GO:0006399) | 2.62218621 |
| 90 | regulation of chronic inflammatory response (GO:0002676) | 2.61781925 |
| 91 | postreplication repair (GO:0006301) | 2.61034822 |
| 92 | formation of translation preinitiation complex (GO:0001731) | 2.60951858 |
| 93 | protein targeting to mitochondrion (GO:0006626) | 2.59908956 |
| 94 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 2.58228568 |
| 95 | UTP biosynthetic process (GO:0006228) | 2.57037114 |
| 96 | protein-cofactor linkage (GO:0018065) | 2.56161894 |
| 97 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.55101418 |
| 98 | organelle disassembly (GO:1903008) | 2.54594407 |
| 99 | cellular component biogenesis (GO:0044085) | 2.54010608 |
| 100 | ncRNA metabolic process (GO:0034660) | 2.53730749 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.90176493 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.42403251 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.89340559 |
| 4 | VDR_22108803_ChIP-Seq_LS180_Human | 3.75147566 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.60755713 |
| 6 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.21888112 |
| 7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.91800381 |
| 8 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.74655601 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.63691540 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.57336592 |
| 11 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.49592848 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.41799887 |
| 13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.40093774 |
| 14 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.39485801 |
| 15 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.35914243 |
| 16 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.34469305 |
| 17 | EWS_26573619_Chip-Seq_HEK293_Human | 2.32480265 |
| 18 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.28306542 |
| 19 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.23572918 |
| 20 | FUS_26573619_Chip-Seq_HEK293_Human | 2.21368338 |
| 21 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.16468976 |
| 22 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.11207240 |
| 23 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.09424117 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.02480906 |
| 25 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.93902708 |
| 26 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.93812494 |
| 27 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.88949497 |
| 28 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.77067984 |
| 29 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.69550027 |
| 30 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.64953501 |
| 31 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.64694589 |
| 32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.64160603 |
| 33 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.61992548 |
| 34 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.61275711 |
| 35 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.59678548 |
| 36 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.59414919 |
| 37 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.51293577 |
| 38 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.48965026 |
| 39 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.48957687 |
| 40 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.48037789 |
| 41 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.44792138 |
| 42 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.42071447 |
| 43 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.39164060 |
| 44 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.39050121 |
| 45 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.38340798 |
| 46 | P300_19829295_ChIP-Seq_ESCs_Human | 1.37261767 |
| 47 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.35297939 |
| 48 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.34894061 |
| 49 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.34485876 |
| 50 | GATA1_22025678_ChIP-Seq_K562_Human | 1.32586826 |
| 51 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.31548232 |
| 52 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.31354554 |
| 53 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.28732272 |
| 54 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.28441977 |
| 55 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.28294387 |
| 56 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.28258811 |
| 57 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.24250383 |
| 58 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.23682618 |
| 59 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.23682618 |
| 60 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.19862995 |
| 61 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.17915614 |
| 62 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.14524571 |
| 63 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.13171980 |
| 64 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.12263661 |
| 65 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.11422291 |
| 66 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.10645506 |
| 67 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.10645506 |
| 68 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.10268754 |
| 69 | GATA3_26560356_Chip-Seq_TH2_Human | 1.08047802 |
| 70 | MYB_26560356_Chip-Seq_TH2_Human | 1.06361163 |
| 71 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.05852267 |
| 72 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.05804467 |
| 73 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.05804467 |
| 74 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.05702679 |
| 75 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.04218658 |
| 76 | AR_20517297_ChIP-Seq_VCAP_Human | 1.02271504 |
| 77 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.02201337 |
| 78 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.99917222 |
| 79 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.98456855 |
| 80 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.97665419 |
| 81 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.97497803 |
| 82 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.96044434 |
| 83 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.94022612 |
| 84 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.92945566 |
| 85 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.91946320 |
| 86 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.91940339 |
| 87 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.90800318 |
| 88 | NCOR_22424771_ChIP-Seq_293T_Human | 0.90668757 |
| 89 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.90229916 |
| 90 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.89469887 |
| 91 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.88731386 |
| 92 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.88489460 |
| 93 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.87156651 |
| 94 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.86129850 |
| 95 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.85639530 |
| 96 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.84945062 |
| 97 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.84783139 |
| 98 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.84551292 |
| 99 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.83794414 |
| 100 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.83321345 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002138_abnormal_hepatobiliary_system | 3.13816217 |
| 2 | MP0004145_abnormal_muscle_electrophysio | 2.98506724 |
| 3 | MP0001835_abnormal_antigen_presentation | 2.92408012 |
| 4 | MP0008877_abnormal_DNA_methylation | 2.88460393 |
| 5 | MP0008057_abnormal_DNA_replication | 2.87184134 |
| 6 | MP0006292_abnormal_olfactory_placode | 2.67245513 |
| 7 | MP0003718_maternal_effect | 2.60735021 |
| 8 | MP0003646_muscle_fatigue | 2.43953064 |
| 9 | MP0006072_abnormal_retinal_apoptosis | 2.37385430 |
| 10 | MP0004147_increased_porphyrin_level | 2.36346637 |
| 11 | MP0008058_abnormal_DNA_repair | 2.23968184 |
| 12 | MP0005671_abnormal_response_to | 2.17481242 |
| 13 | MP0010094_abnormal_chromosome_stability | 2.16126257 |
| 14 | MP0002102_abnormal_ear_morphology | 2.15448963 |
| 15 | MP0004957_abnormal_blastocyst_morpholog | 2.09576682 |
| 16 | MP0002837_dystrophic_cardiac_calcinosis | 2.09054994 |
| 17 | MP0003786_premature_aging | 2.06952334 |
| 18 | MP0005084_abnormal_gallbladder_morpholo | 1.93015505 |
| 19 | MP0001188_hyperpigmentation | 1.90702563 |
| 20 | MP0001873_stomach_inflammation | 1.87303483 |
| 21 | MP0000685_abnormal_immune_system | 1.81252193 |
| 22 | MP0004215_abnormal_myocardial_fiber | 1.78347352 |
| 23 | MP0008872_abnormal_physiological_respon | 1.75014824 |
| 24 | MP0000372_irregular_coat_pigmentation | 1.69178899 |
| 25 | MP0005646_abnormal_pituitary_gland | 1.67730411 |
| 26 | MP0004885_abnormal_endolymph | 1.63312660 |
| 27 | MP0006036_abnormal_mitochondrial_physio | 1.58698358 |
| 28 | MP0003693_abnormal_embryo_hatching | 1.51583772 |
| 29 | MP0001529_abnormal_vocalization | 1.41971978 |
| 30 | MP0003806_abnormal_nucleotide_metabolis | 1.39611854 |
| 31 | MP0002876_abnormal_thyroid_physiology | 1.38395158 |
| 32 | MP0009333_abnormal_splenocyte_physiolog | 1.37258291 |
| 33 | MP0001968_abnormal_touch/_nociception | 1.36394743 |
| 34 | MP0004036_abnormal_muscle_relaxation | 1.36173981 |
| 35 | MP0008007_abnormal_cellular_replicative | 1.35945600 |
| 36 | MP0000749_muscle_degeneration | 1.32287018 |
| 37 | MP0003077_abnormal_cell_cycle | 1.31682162 |
| 38 | MP0003567_abnormal_fetal_cardiomyocyte | 1.30983191 |
| 39 | MP0006035_abnormal_mitochondrial_morpho | 1.28880673 |
| 40 | MP0002277_abnormal_respiratory_mucosa | 1.28315644 |
| 41 | MP0004142_abnormal_muscle_tone | 1.25687500 |
| 42 | MP0002006_tumorigenesis | 1.23795241 |
| 43 | MP0002148_abnormal_hypersensitivity_rea | 1.23740537 |
| 44 | MP0005253_abnormal_eye_physiology | 1.23658149 |
| 45 | MP0003950_abnormal_plasma_membrane | 1.22844338 |
| 46 | MP0003195_calcinosis | 1.21436163 |
| 47 | MP0002736_abnormal_nociception_after | 1.19940486 |
| 48 | MP0009379_abnormal_foot_pigmentation | 1.19213620 |
| 49 | MP0005551_abnormal_eye_electrophysiolog | 1.16818879 |
| 50 | MP0001800_abnormal_humoral_immune | 1.16098453 |
| 51 | MP0000631_abnormal_neuroendocrine_gland | 1.15644737 |
| 52 | MP0003011_delayed_dark_adaptation | 1.14804898 |
| 53 | MP0002166_altered_tumor_susceptibility | 1.12913584 |
| 54 | MP0002163_abnormal_gland_morphology | 1.11878991 |
| 55 | MP0005389_reproductive_system_phenotype | 1.11775725 |
| 56 | MP0000465_gastrointestinal_hemorrhage | 1.09035997 |
| 57 | MP0005645_abnormal_hypothalamus_physiol | 1.08359886 |
| 58 | MP0009697_abnormal_copulation | 1.08215590 |
| 59 | MP0010368_abnormal_lymphatic_system | 1.08161590 |
| 60 | MP0004134_abnormal_chest_morphology | 1.05850470 |
| 61 | MP0001661_extended_life_span | 1.01575764 |
| 62 | MP0008875_abnormal_xenobiotic_pharmacok | 0.99113123 |
| 63 | MP0005387_immune_system_phenotype | 0.97157824 |
| 64 | MP0001790_abnormal_immune_system | 0.97157824 |
| 65 | MP0009764_decreased_sensitivity_to | 0.96299087 |
| 66 | MP0003763_abnormal_thymus_physiology | 0.96192993 |
| 67 | MP0002160_abnormal_reproductive_system | 0.95511998 |
| 68 | MP0009250_abnormal_appendicular_skeleto | 0.94634681 |
| 69 | MP0001485_abnormal_pinna_reflex | 0.94490810 |
| 70 | MP0005360_urolithiasis | 0.93354139 |
| 71 | MP0002269_muscular_atrophy | 0.93135150 |
| 72 | MP0001293_anophthalmia | 0.92795494 |
| 73 | MP0003111_abnormal_nucleus_morphology | 0.92447596 |
| 74 | MP0000689_abnormal_spleen_morphology | 0.92318232 |
| 75 | MP0009785_altered_susceptibility_to | 0.91836631 |
| 76 | MP0002398_abnormal_bone_marrow | 0.91099435 |
| 77 | MP0005379_endocrine/exocrine_gland_phen | 0.90778129 |
| 78 | MP0005636_abnormal_mineral_homeostasis | 0.89651954 |
| 79 | MP0000703_abnormal_thymus_morphology | 0.88476783 |
| 80 | MP0002396_abnormal_hematopoietic_system | 0.87461396 |
| 81 | MP0000747_muscle_weakness | 0.86513270 |
| 82 | MP0008995_early_reproductive_senescence | 0.85949732 |
| 83 | MP0003186_abnormal_redox_activity | 0.84818551 |
| 84 | MP0003866_abnormal_defecation | 0.83957887 |
| 85 | MP0005000_abnormal_immune_tolerance | 0.82499176 |
| 86 | MP0002106_abnormal_muscle_physiology | 0.81248425 |
| 87 | MP0001986_abnormal_taste_sensitivity | 0.80923435 |
| 88 | MP0002723_abnormal_immune_serum | 0.80138530 |
| 89 | MP0001919_abnormal_reproductive_system | 0.78476523 |
| 90 | MP0002019_abnormal_tumor_incidence | 0.77960236 |
| 91 | MP0001119_abnormal_female_reproductive | 0.77055184 |
| 92 | MP0002722_abnormal_immune_system | 0.76574388 |
| 93 | MP0002095_abnormal_skin_pigmentation | 0.75745365 |
| 94 | MP0004084_abnormal_cardiac_muscle | 0.75564073 |
| 95 | MP0002420_abnormal_adaptive_immunity | 0.74973093 |
| 96 | MP0003252_abnormal_bile_duct | 0.74521507 |
| 97 | MP0002210_abnormal_sex_determination | 0.74031126 |
| 98 | MP0001853_heart_inflammation | 0.74014840 |
| 99 | MP0000716_abnormal_immune_system | 0.73852039 |
| 100 | MP0002127_abnormal_cardiovascular_syste | 0.73310632 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.00557014 |
| 2 | Increased CSF lactate (HP:0002490) | 3.85410616 |
| 3 | Mitochondrial inheritance (HP:0001427) | 3.81653171 |
| 4 | Hepatocellular necrosis (HP:0001404) | 3.65781064 |
| 5 | Acute encephalopathy (HP:0006846) | 3.43574145 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.41864429 |
| 7 | Hepatic necrosis (HP:0002605) | 3.35048285 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.31062108 |
| 9 | 3-Methylglutaconic aciduria (HP:0003535) | 3.26347095 |
| 10 | Reduced antithrombin III activity (HP:0001976) | 3.24811458 |
| 11 | IgG deficiency (HP:0004315) | 3.07059232 |
| 12 | Congenital stationary night blindness (HP:0007642) | 3.03430686 |
| 13 | Increased hepatocellular lipid droplets (HP:0006565) | 3.02734656 |
| 14 | Nemaline bodies (HP:0003798) | 2.91589141 |
| 15 | Pancreatic cysts (HP:0001737) | 2.84870406 |
| 16 | Increased serum lactate (HP:0002151) | 2.83469366 |
| 17 | Lipid accumulation in hepatocytes (HP:0006561) | 2.79878358 |
| 18 | Cerebral edema (HP:0002181) | 2.69410544 |
| 19 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 2.65896842 |
| 20 | B lymphocytopenia (HP:0010976) | 2.65667723 |
| 21 | Stomatitis (HP:0010280) | 2.61149773 |
| 22 | Decreased central vision (HP:0007663) | 2.60819360 |
| 23 | Abnormality of the pons (HP:0007361) | 2.57050697 |
| 24 | Abnormality of B cell number (HP:0010975) | 2.56923221 |
| 25 | Colon cancer (HP:0003003) | 2.54111375 |
| 26 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.43211194 |
| 27 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.41827767 |
| 28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.40824293 |
| 29 | Muscle fiber inclusion bodies (HP:0100299) | 2.39191955 |
| 30 | Abnormality of the ileum (HP:0001549) | 2.36227750 |
| 31 | Exertional dyspnea (HP:0002875) | 2.34926877 |
| 32 | Abolished electroretinogram (ERG) (HP:0000550) | 2.34255595 |
| 33 | Aplastic anemia (HP:0001915) | 2.32624816 |
| 34 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.31907820 |
| 35 | Methylmalonic acidemia (HP:0002912) | 2.31255154 |
| 36 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.29568366 |
| 37 | Lactic acidosis (HP:0003128) | 2.28410321 |
| 38 | Type I transferrin isoform profile (HP:0003642) | 2.28244357 |
| 39 | Congenital, generalized hypertrichosis (HP:0004540) | 2.28079729 |
| 40 | Meckel diverticulum (HP:0002245) | 2.26001591 |
| 41 | Hypoplasia of the pons (HP:0012110) | 2.25187705 |
| 42 | Optic disc pallor (HP:0000543) | 2.23035313 |
| 43 | Type II lissencephaly (HP:0007260) | 2.20457076 |
| 44 | Fibular aplasia (HP:0002990) | 2.19992238 |
| 45 | Exercise intolerance (HP:0003546) | 2.18193215 |
| 46 | Autoimmune hemolytic anemia (HP:0001890) | 2.17727066 |
| 47 | Type 2 muscle fiber atrophy (HP:0003554) | 2.15741446 |
| 48 | Absent phalangeal crease (HP:0006109) | 2.14975719 |
| 49 | Abnormality of macular pigmentation (HP:0008002) | 2.13836168 |
| 50 | Short tibia (HP:0005736) | 2.13475553 |
| 51 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.11235261 |
| 52 | Hypoproteinemia (HP:0003075) | 2.11056224 |
| 53 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 2.07612332 |
| 54 | Supernumerary spleens (HP:0009799) | 2.06797340 |
| 55 | Abnormality of midbrain morphology (HP:0002418) | 2.06616533 |
| 56 | Molar tooth sign on MRI (HP:0002419) | 2.06616533 |
| 57 | Abnormality of alanine metabolism (HP:0010916) | 2.05369352 |
| 58 | Hyperalaninemia (HP:0003348) | 2.05369352 |
| 59 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.05369352 |
| 60 | Respiratory failure (HP:0002878) | 2.05118925 |
| 61 | Abnormal finger flexion creases (HP:0006143) | 2.03433579 |
| 62 | Renal Fanconi syndrome (HP:0001994) | 2.02149097 |
| 63 | Hyperglycinemia (HP:0002154) | 2.01006049 |
| 64 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.00050394 |
| 65 | Microvesicular hepatic steatosis (HP:0001414) | 1.98262549 |
| 66 | Methylmalonic aciduria (HP:0012120) | 1.98124543 |
| 67 | Abnormal glycosylation (HP:0012345) | 1.97097610 |
| 68 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.97097610 |
| 69 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.97097610 |
| 70 | Abnormal protein glycosylation (HP:0012346) | 1.97097610 |
| 71 | Conjunctival hamartoma (HP:0100780) | 1.95818465 |
| 72 | Palpebral edema (HP:0100540) | 1.93590898 |
| 73 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.92323098 |
| 74 | Clubbing of toes (HP:0100760) | 1.88582896 |
| 75 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.88405780 |
| 76 | Oral leukoplakia (HP:0002745) | 1.88124884 |
| 77 | Increased IgM level (HP:0003496) | 1.87636709 |
| 78 | Abnormality of serum amino acid levels (HP:0003112) | 1.86325709 |
| 79 | Chronic sinusitis (HP:0011109) | 1.85101108 |
| 80 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.84344005 |
| 81 | Leukodystrophy (HP:0002415) | 1.82598789 |
| 82 | Abnormality of T cell physiology (HP:0011840) | 1.82461913 |
| 83 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.81742805 |
| 84 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.81635172 |
| 85 | Abnormality of the renal cortex (HP:0011035) | 1.80722680 |
| 86 | CNS demyelination (HP:0007305) | 1.80010026 |
| 87 | Abnormality of the prostate (HP:0008775) | 1.78672222 |
| 88 | Abnormality of chromosome stability (HP:0003220) | 1.78134250 |
| 89 | Nephronophthisis (HP:0000090) | 1.77690873 |
| 90 | Pendular nystagmus (HP:0012043) | 1.74647252 |
| 91 | Abnormality of the renal collecting system (HP:0004742) | 1.74378700 |
| 92 | Lethargy (HP:0001254) | 1.74186606 |
| 93 | Pancreatic fibrosis (HP:0100732) | 1.73767858 |
| 94 | Distal arthrogryposis (HP:0005684) | 1.73115212 |
| 95 | IgM deficiency (HP:0002850) | 1.72287762 |
| 96 | Muscle hypertrophy of the lower extremities (HP:0008968) | 1.71936799 |
| 97 | Thyroiditis (HP:0100646) | 1.70771149 |
| 98 | Delayed CNS myelination (HP:0002188) | 1.69842310 |
| 99 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.69603129 |
| 100 | Increased corneal curvature (HP:0100692) | 1.68292620 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EIF2AK3 | 3.24946342 |
| 2 | MST4 | 3.03619322 |
| 3 | NUAK1 | 2.86844114 |
| 4 | ZAK | 2.84519820 |
| 5 | TIE1 | 2.82321084 |
| 6 | TAOK3 | 2.76368208 |
| 7 | TXK | 2.75661831 |
| 8 | VRK2 | 2.74624571 |
| 9 | BUB1 | 2.27771714 |
| 10 | STK16 | 2.21135812 |
| 11 | EIF2AK1 | 2.18004717 |
| 12 | TLK1 | 2.15068410 |
| 13 | OBSCN | 2.13909988 |
| 14 | BCKDK | 2.06570780 |
| 15 | TNIK | 2.01593803 |
| 16 | TSSK6 | 2.01365991 |
| 17 | MKNK2 | 1.95103693 |
| 18 | GRK1 | 1.94665322 |
| 19 | NME2 | 1.87040593 |
| 20 | PBK | 1.82343972 |
| 21 | SRPK1 | 1.77136018 |
| 22 | MKNK1 | 1.74197986 |
| 23 | PHKG2 | 1.73527786 |
| 24 | PHKG1 | 1.73527786 |
| 25 | BMPR1B | 1.72958124 |
| 26 | TEC | 1.68437631 |
| 27 | VRK1 | 1.66602244 |
| 28 | TAF1 | 1.60706595 |
| 29 | PLK3 | 1.57248970 |
| 30 | MAP3K12 | 1.53271912 |
| 31 | NME1 | 1.41579158 |
| 32 | MAP4K2 | 1.34622043 |
| 33 | EIF2AK2 | 1.34282038 |
| 34 | PLK4 | 1.31934836 |
| 35 | PINK1 | 1.30581856 |
| 36 | ADRBK2 | 1.30188806 |
| 37 | FRK | 1.19990382 |
| 38 | OXSR1 | 1.17338238 |
| 39 | TRIM28 | 1.13821218 |
| 40 | WNK4 | 1.13006037 |
| 41 | WNK3 | 1.12848699 |
| 42 | ITK | 1.10450934 |
| 43 | NEK1 | 1.04464514 |
| 44 | CSNK1A1L | 1.00004808 |
| 45 | ACVR1B | 0.92965588 |
| 46 | CSNK1G3 | 0.90049327 |
| 47 | TESK2 | 0.88796565 |
| 48 | DAPK1 | 0.88024203 |
| 49 | CSNK1G1 | 0.83643926 |
| 50 | MAP2K6 | 0.83233125 |
| 51 | STK39 | 0.78907511 |
| 52 | CDK19 | 0.75223702 |
| 53 | ATR | 0.74719302 |
| 54 | PLK1 | 0.73148276 |
| 55 | NLK | 0.71942816 |
| 56 | MYLK | 0.71541421 |
| 57 | JAK3 | 0.70382769 |
| 58 | KDR | 0.69205066 |
| 59 | TGFBR1 | 0.66305446 |
| 60 | TTK | 0.64522539 |
| 61 | CDC7 | 0.62708651 |
| 62 | KIT | 0.62350191 |
| 63 | PASK | 0.62334219 |
| 64 | FLT3 | 0.61926708 |
| 65 | STK3 | 0.57890864 |
| 66 | CSNK1G2 | 0.56907038 |
| 67 | ERBB3 | 0.56332620 |
| 68 | DYRK2 | 0.55988528 |
| 69 | ALK | 0.55965643 |
| 70 | CHEK2 | 0.55315802 |
| 71 | MAP3K13 | 0.52641808 |
| 72 | IKBKB | 0.52588080 |
| 73 | PRKCQ | 0.52100551 |
| 74 | STK38L | 0.50932171 |
| 75 | INSRR | 0.46032559 |
| 76 | BTK | 0.45752910 |
| 77 | CSNK2A1 | 0.45327445 |
| 78 | BCR | 0.45256179 |
| 79 | AURKB | 0.45137098 |
| 80 | PLK2 | 0.44711940 |
| 81 | CCNB1 | 0.44318799 |
| 82 | RPS6KA5 | 0.42827208 |
| 83 | DAPK2 | 0.42682251 |
| 84 | SCYL2 | 0.40684068 |
| 85 | ATM | 0.39344245 |
| 86 | AKT3 | 0.38887619 |
| 87 | WNK1 | 0.38563083 |
| 88 | CSNK2A2 | 0.38321071 |
| 89 | NEK2 | 0.37142675 |
| 90 | PRKCE | 0.36196677 |
| 91 | GRK6 | 0.35611159 |
| 92 | SYK | 0.35089367 |
| 93 | RPS6KA4 | 0.34687965 |
| 94 | IGF1R | 0.32812062 |
| 95 | LCK | 0.32505676 |
| 96 | PRKG1 | 0.28445813 |
| 97 | MAP4K1 | 0.27614516 |
| 98 | MAP3K14 | 0.26076443 |
| 99 | FGFR1 | 0.25598590 |
| 100 | PRKACA | 0.24405583 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.01849846 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.98298584 |
| 3 | Asthma_Homo sapiens_hsa05310 | 2.97678081 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 2.96442183 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.96104663 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.88275504 |
| 7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.73841308 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.32238839 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.30384561 |
| 10 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.21459065 |
| 11 | Allograft rejection_Homo sapiens_hsa05330 | 2.20859541 |
| 12 | Mismatch repair_Homo sapiens_hsa03430 | 2.20143190 |
| 13 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.15227706 |
| 14 | RNA degradation_Homo sapiens_hsa03018 | 1.97731572 |
| 15 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.94798763 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 1.90087595 |
| 17 | DNA replication_Homo sapiens_hsa03030 | 1.85650933 |
| 18 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.82562897 |
| 19 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.78619136 |
| 20 | RNA transport_Homo sapiens_hsa03013 | 1.73921816 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.72091190 |
| 22 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.71219584 |
| 23 | Spliceosome_Homo sapiens_hsa03040 | 1.66984415 |
| 24 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.62020127 |
| 25 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.61839781 |
| 26 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.59927636 |
| 27 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.56090513 |
| 28 | Huntingtons disease_Homo sapiens_hsa05016 | 1.54781033 |
| 29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.48423889 |
| 30 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.42758251 |
| 31 | Alzheimers disease_Homo sapiens_hsa05010 | 1.42683620 |
| 32 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.42542463 |
| 33 | Base excision repair_Homo sapiens_hsa03410 | 1.34096692 |
| 34 | Purine metabolism_Homo sapiens_hsa00230 | 1.29534269 |
| 35 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.23935842 |
| 36 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.15967525 |
| 37 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.11234515 |
| 38 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.09271071 |
| 39 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.08531410 |
| 40 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.03773565 |
| 41 | Phototransduction_Homo sapiens_hsa04744 | 1.03050338 |
| 42 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.98677478 |
| 43 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.97733214 |
| 44 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.93317364 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.88215214 |
| 46 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.81332396 |
| 47 | Peroxisome_Homo sapiens_hsa04146 | 0.79669774 |
| 48 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.78629433 |
| 49 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.77836430 |
| 50 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.77535523 |
| 51 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.77524036 |
| 52 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.74585786 |
| 53 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.68930380 |
| 54 | Olfactory transduction_Homo sapiens_hsa04740 | 0.67872978 |
| 55 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.66204328 |
| 56 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.65796571 |
| 57 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.63320700 |
| 58 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.62361014 |
| 59 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.61210143 |
| 60 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.58169209 |
| 61 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.57842130 |
| 62 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.57048324 |
| 63 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.56588515 |
| 64 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.55704528 |
| 65 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.54677359 |
| 66 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.53865858 |
| 67 | Retinol metabolism_Homo sapiens_hsa00830 | 0.51728223 |
| 68 | Viral myocarditis_Homo sapiens_hsa05416 | 0.50843397 |
| 69 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.50596356 |
| 70 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.49581469 |
| 71 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.49318612 |
| 72 | Metabolic pathways_Homo sapiens_hsa01100 | 0.49275180 |
| 73 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.48877265 |
| 74 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.48391173 |
| 75 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.47920422 |
| 76 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.47807485 |
| 77 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.47551038 |
| 78 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.47271444 |
| 79 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.44843108 |
| 80 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.44205148 |
| 81 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.44168968 |
| 82 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.42448984 |
| 83 | Measles_Homo sapiens_hsa05162 | 0.42321158 |
| 84 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.41992760 |
| 85 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.40882723 |
| 86 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.40702347 |
| 87 | Cell cycle_Homo sapiens_hsa04110 | 0.38802523 |
| 88 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.34658988 |
| 89 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.32737444 |
| 90 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.32473684 |
| 91 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.32142164 |
| 92 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.32039793 |
| 93 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.30986191 |
| 94 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.28662355 |
| 95 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.27052778 |
| 96 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.23523733 |
| 97 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.22601505 |
| 98 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.21693676 |
| 99 | Carbon metabolism_Homo sapiens_hsa01200 | 0.20611619 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.20102296 |

