

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.11399760 |
| 2 | DNA deamination (GO:0045006) | 4.84548089 |
| 3 | ribosome assembly (GO:0042255) | 4.63584483 |
| 4 | rRNA modification (GO:0000154) | 4.54912765 |
| 5 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.50611942 |
| 6 | regulation of immunoglobulin secretion (GO:0051023) | 4.37097462 |
| 7 | rRNA methylation (GO:0031167) | 4.21757223 |
| 8 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.19615904 |
| 9 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.11175977 |
| 10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.05130779 |
| 11 | pseudouridine synthesis (GO:0001522) | 3.86168994 |
| 12 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.83715133 |
| 13 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.83156602 |
| 14 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.81273558 |
| 15 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.80261839 |
| 16 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.80079729 |
| 17 | isotype switching (GO:0045190) | 3.80079729 |
| 18 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.80079729 |
| 19 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.79068339 |
| 20 | IMP biosynthetic process (GO:0006188) | 3.78676671 |
| 21 | maturation of 5.8S rRNA (GO:0000460) | 3.78456110 |
| 22 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.76880685 |
| 23 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.76880685 |
| 24 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.76880685 |
| 25 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.74055232 |
| 26 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.74055232 |
| 27 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.73660262 |
| 28 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.68662724 |
| 29 | negative regulation of ligase activity (GO:0051352) | 3.68662724 |
| 30 | tRNA aminoacylation (GO:0043039) | 3.67803752 |
| 31 | amino acid activation (GO:0043038) | 3.67803752 |
| 32 | regulation of chronic inflammatory response (GO:0002676) | 3.65779697 |
| 33 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.64502262 |
| 34 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.64502262 |
| 35 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.62818244 |
| 36 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.61859592 |
| 37 | tRNA aminoacylation for protein translation (GO:0006418) | 3.59608608 |
| 38 | ribosome biogenesis (GO:0042254) | 3.59486881 |
| 39 | cullin deneddylation (GO:0010388) | 3.57686859 |
| 40 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.57404933 |
| 41 | rRNA processing (GO:0006364) | 3.57392330 |
| 42 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.56362908 |
| 43 | positive regulation of isotype switching (GO:0045830) | 3.53507129 |
| 44 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.52270699 |
| 45 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.51007967 |
| 46 | termination of RNA polymerase I transcription (GO:0006363) | 3.47926659 |
| 47 | rRNA metabolic process (GO:0016072) | 3.45557141 |
| 48 | protein complex biogenesis (GO:0070271) | 3.44430071 |
| 49 | positive regulation of immune response to tumor cell (GO:0002839) | 3.44254862 |
| 50 | regulation of immune response to tumor cell (GO:0002837) | 3.44254862 |
| 51 | regulation of response to tumor cell (GO:0002834) | 3.44254862 |
| 52 | positive regulation of response to tumor cell (GO:0002836) | 3.44254862 |
| 53 | positive regulation of DNA recombination (GO:0045911) | 3.43822810 |
| 54 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.41859958 |
| 55 | regulation of regulatory T cell differentiation (GO:0045589) | 3.40709070 |
| 56 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.38900061 |
| 57 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.38900061 |
| 58 | NADH dehydrogenase complex assembly (GO:0010257) | 3.38900061 |
| 59 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.37472912 |
| 60 | purine nucleobase biosynthetic process (GO:0009113) | 3.37049941 |
| 61 | mitochondrial RNA metabolic process (GO:0000959) | 3.34042983 |
| 62 | transcription from mitochondrial promoter (GO:0006390) | 3.32115690 |
| 63 | DNA double-strand break processing (GO:0000729) | 3.31902519 |
| 64 | protein deneddylation (GO:0000338) | 3.31527521 |
| 65 | nucleobase biosynthetic process (GO:0046112) | 3.31154405 |
| 66 | protein neddylation (GO:0045116) | 3.29526858 |
| 67 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.28011587 |
| 68 | formation of translation preinitiation complex (GO:0001731) | 3.24175332 |
| 69 | ribosomal large subunit biogenesis (GO:0042273) | 3.21605608 |
| 70 | somatic diversification of immunoglobulins (GO:0016445) | 3.20653322 |
| 71 | IMP metabolic process (GO:0046040) | 3.19812153 |
| 72 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.19744872 |
| 73 | termination of RNA polymerase III transcription (GO:0006386) | 3.19744872 |
| 74 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.18945498 |
| 75 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.18945498 |
| 76 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 3.17779140 |
| 77 | positive regulation of ligase activity (GO:0051351) | 3.16493855 |
| 78 | tRNA metabolic process (GO:0006399) | 3.16436606 |
| 79 | respiratory chain complex IV assembly (GO:0008535) | 3.04756346 |
| 80 | ncRNA metabolic process (GO:0034660) | 3.03332124 |
| 81 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.01068066 |
| 82 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.01048903 |
| 83 | positive regulation of cell cycle arrest (GO:0071158) | 2.98939146 |
| 84 | chaperone-mediated protein transport (GO:0072321) | 2.98245534 |
| 85 | tRNA processing (GO:0008033) | 2.97334315 |
| 86 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.95878533 |
| 87 | ATP synthesis coupled proton transport (GO:0015986) | 2.95878533 |
| 88 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.93913482 |
| 89 | spliceosomal snRNP assembly (GO:0000387) | 2.93849063 |
| 90 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.93499663 |
| 91 | cellular component biogenesis (GO:0044085) | 2.93292071 |
| 92 | ncRNA processing (GO:0034470) | 2.91304797 |
| 93 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.90964745 |
| 94 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.86291639 |
| 95 | DNA replication checkpoint (GO:0000076) | 2.85796282 |
| 96 | protein targeting to mitochondrion (GO:0006626) | 2.85393239 |
| 97 | DNA damage response, detection of DNA damage (GO:0042769) | 2.84310053 |
| 98 | GTP biosynthetic process (GO:0006183) | 2.84142554 |
| 99 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.82072170 |
| 100 | transcription from RNA polymerase I promoter (GO:0006360) | 2.81615960 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.46024180 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.80958441 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.40409399 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.38355545 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.17703545 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.52390649 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.41774059 |
| 8 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.27350930 |
| 9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.20721906 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.09208438 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.99024222 |
| 12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.87916115 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.78635611 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.72433665 |
| 15 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.52290691 |
| 16 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.51935858 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.50947274 |
| 18 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.50527028 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.49090781 |
| 20 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.30300540 |
| 21 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.25107476 |
| 22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.24218746 |
| 23 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.07257935 |
| 24 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.03713266 |
| 25 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.99064848 |
| 26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.97957215 |
| 27 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.97293306 |
| 28 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.93441395 |
| 29 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.89630644 |
| 30 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.89136030 |
| 31 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.85547900 |
| 32 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.83855024 |
| 33 | VDR_22108803_ChIP-Seq_LS180_Human | 1.78646682 |
| 34 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.76848025 |
| 35 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.71858029 |
| 36 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.71410532 |
| 37 | EWS_26573619_Chip-Seq_HEK293_Human | 1.69633885 |
| 38 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.66797921 |
| 39 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.65335679 |
| 40 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.64402544 |
| 41 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.63893925 |
| 42 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.62126541 |
| 43 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.61466277 |
| 44 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.60976799 |
| 45 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.57369565 |
| 46 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.53898737 |
| 47 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.50043187 |
| 48 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.45213750 |
| 49 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.45010911 |
| 50 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.42129083 |
| 51 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.40911296 |
| 52 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.34594979 |
| 53 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.31737779 |
| 54 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.26949289 |
| 55 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.26181014 |
| 56 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.22570790 |
| 57 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.18787677 |
| 58 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.17297690 |
| 59 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.17026598 |
| 60 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.16406173 |
| 61 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.13736107 |
| 62 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.12787939 |
| 63 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.12693656 |
| 64 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.12156556 |
| 65 | FUS_26573619_Chip-Seq_HEK293_Human | 1.08441180 |
| 66 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06824108 |
| 67 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.03801563 |
| 68 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.98894046 |
| 69 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.97736415 |
| 70 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.97050720 |
| 71 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.97050720 |
| 72 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95977781 |
| 73 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94475845 |
| 74 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.93735255 |
| 75 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 0.92623887 |
| 76 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.91435559 |
| 77 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.88763222 |
| 78 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.88268782 |
| 79 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.86817497 |
| 80 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.86414123 |
| 81 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.86033915 |
| 82 | GATA3_26560356_Chip-Seq_TH2_Human | 0.85929880 |
| 83 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.85554309 |
| 84 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.84286948 |
| 85 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.83923226 |
| 86 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.83678726 |
| 87 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83186179 |
| 88 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.81107854 |
| 89 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.80624168 |
| 90 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.80537103 |
| 91 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.79529319 |
| 92 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.78732826 |
| 93 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.78732826 |
| 94 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.78227653 |
| 95 | P300_19829295_ChIP-Seq_ESCs_Human | 0.77654540 |
| 96 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.77235217 |
| 97 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.75888702 |
| 98 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.72980840 |
| 99 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.72539019 |
| 100 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.72316484 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.62293870 |
| 2 | MP0008057_abnormal_DNA_replication | 3.40429584 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.37482419 |
| 4 | MP0003693_abnormal_embryo_hatching | 3.31717884 |
| 5 | MP0010094_abnormal_chromosome_stability | 3.20609939 |
| 6 | MP0001348_abnormal_lacrimal_gland | 3.07378605 |
| 7 | MP0002102_abnormal_ear_morphology | 2.95981215 |
| 8 | MP0000685_abnormal_immune_system | 2.82630460 |
| 9 | MP0004957_abnormal_blastocyst_morpholog | 2.78924767 |
| 10 | MP0003786_premature_aging | 2.67917468 |
| 11 | MP0003718_maternal_effect | 2.60988346 |
| 12 | MP0001873_stomach_inflammation | 2.32299388 |
| 13 | MP0003806_abnormal_nucleotide_metabolis | 2.31323225 |
| 14 | MP0008872_abnormal_physiological_respon | 2.29257180 |
| 15 | MP0008007_abnormal_cellular_replicative | 2.26167463 |
| 16 | MP0004147_increased_porphyrin_level | 2.20582236 |
| 17 | MP0003077_abnormal_cell_cycle | 2.09024504 |
| 18 | MP0006036_abnormal_mitochondrial_physio | 2.03064407 |
| 19 | MP0006035_abnormal_mitochondrial_morpho | 1.95970935 |
| 20 | MP0005671_abnormal_response_to | 1.93172568 |
| 21 | MP0003111_abnormal_nucleus_morphology | 1.90630329 |
| 22 | MP0009333_abnormal_splenocyte_physiolog | 1.82266155 |
| 23 | MP0002138_abnormal_hepatobiliary_system | 1.79295703 |
| 24 | MP0001790_abnormal_immune_system | 1.76315789 |
| 25 | MP0005387_immune_system_phenotype | 1.76315789 |
| 26 | MP0008875_abnormal_xenobiotic_pharmacok | 1.75877300 |
| 27 | MP0002163_abnormal_gland_morphology | 1.69649621 |
| 28 | MP0002006_tumorigenesis | 1.64269886 |
| 29 | MP0003567_abnormal_fetal_cardiomyocyte | 1.61125726 |
| 30 | MP0003646_muscle_fatigue | 1.60005489 |
| 31 | MP0008877_abnormal_DNA_methylation | 1.51278358 |
| 32 | MP0005084_abnormal_gallbladder_morpholo | 1.50362902 |
| 33 | MP0005379_endocrine/exocrine_gland_phen | 1.49126757 |
| 34 | MP0004782_abnormal_surfactant_physiolog | 1.48305398 |
| 35 | MP0000372_irregular_coat_pigmentation | 1.47845290 |
| 36 | MP0001529_abnormal_vocalization | 1.43631023 |
| 37 | MP0003763_abnormal_thymus_physiology | 1.43193661 |
| 38 | MP0005075_abnormal_melanosome_morpholog | 1.42893349 |
| 39 | MP0002166_altered_tumor_susceptibility | 1.41785521 |
| 40 | MP0002837_dystrophic_cardiac_calcinosis | 1.38065301 |
| 41 | MP0009785_altered_susceptibility_to | 1.36799588 |
| 42 | MP0006072_abnormal_retinal_apoptosis | 1.35182442 |
| 43 | MP0006292_abnormal_olfactory_placode | 1.33320349 |
| 44 | MP0005310_abnormal_salivary_gland | 1.29561778 |
| 45 | MP0001800_abnormal_humoral_immune | 1.26084635 |
| 46 | MP0001293_anophthalmia | 1.25484336 |
| 47 | MP0002148_abnormal_hypersensitivity_rea | 1.25161775 |
| 48 | MP0003186_abnormal_redox_activity | 1.24972726 |
| 49 | MP0000569_abnormal_digit_pigmentation | 1.22058440 |
| 50 | MP0008932_abnormal_embryonic_tissue | 1.21092459 |
| 51 | MP0004145_abnormal_muscle_electrophysio | 1.18956029 |
| 52 | MP0005645_abnormal_hypothalamus_physiol | 1.18731392 |
| 53 | MP0005408_hypopigmentation | 1.17701351 |
| 54 | MP0001853_heart_inflammation | 1.17580672 |
| 55 | MP0002277_abnormal_respiratory_mucosa | 1.13452641 |
| 56 | MP0004142_abnormal_muscle_tone | 1.13146459 |
| 57 | MP0001188_hyperpigmentation | 1.01085550 |
| 58 | MP0005174_abnormal_tail_pigmentation | 1.00976927 |
| 59 | MP0009697_abnormal_copulation | 1.00966820 |
| 60 | MP0000689_abnormal_spleen_morphology | 0.99938181 |
| 61 | MP0005389_reproductive_system_phenotype | 0.98440070 |
| 62 | MP0005000_abnormal_immune_tolerance | 0.97262579 |
| 63 | MP0002160_abnormal_reproductive_system | 0.97033323 |
| 64 | MP0002736_abnormal_nociception_after | 0.96482882 |
| 65 | MP0002398_abnormal_bone_marrow | 0.94322656 |
| 66 | MP0000703_abnormal_thymus_morphology | 0.93989052 |
| 67 | MP0002405_respiratory_system_inflammati | 0.92266685 |
| 68 | MP0002396_abnormal_hematopoietic_system | 0.90605417 |
| 69 | MP0001968_abnormal_touch/_nociception | 0.88652248 |
| 70 | MP0001919_abnormal_reproductive_system | 0.88091880 |
| 71 | MP0002019_abnormal_tumor_incidence | 0.87667397 |
| 72 | MP0005410_abnormal_fertilization | 0.87149501 |
| 73 | MP0002210_abnormal_sex_determination | 0.87061679 |
| 74 | MP0001881_abnormal_mammary_gland | 0.84600524 |
| 75 | MP0001929_abnormal_gametogenesis | 0.83268941 |
| 76 | MP0000490_abnormal_crypts_of | 0.81608997 |
| 77 | MP0001986_abnormal_taste_sensitivity | 0.79939189 |
| 78 | MP0002722_abnormal_immune_system | 0.77739261 |
| 79 | MP0001661_extended_life_span | 0.77105558 |
| 80 | MP0001501_abnormal_sleep_pattern | 0.76870187 |
| 81 | MP0002938_white_spotting | 0.76026379 |
| 82 | MP0003936_abnormal_reproductive_system | 0.75202978 |
| 83 | MP0002751_abnormal_autonomic_nervous | 0.74197030 |
| 84 | MP0000313_abnormal_cell_death | 0.73814766 |
| 85 | MP0002723_abnormal_immune_serum | 0.73504570 |
| 86 | MP0002429_abnormal_blood_cell | 0.71616738 |
| 87 | MP0000358_abnormal_cell_content/ | 0.71397363 |
| 88 | MP0001764_abnormal_homeostasis | 0.70863231 |
| 89 | MP0001119_abnormal_female_reproductive | 0.70863120 |
| 90 | MP0002452_abnormal_antigen_presenting | 0.69961945 |
| 91 | MP0002420_abnormal_adaptive_immunity | 0.69765764 |
| 92 | MP0004215_abnormal_myocardial_fiber | 0.68690309 |
| 93 | MP0001697_abnormal_embryo_size | 0.67446181 |
| 94 | MP0003195_calcinosis | 0.67276388 |
| 95 | MP0008995_early_reproductive_senescence | 0.67054131 |
| 96 | MP0005646_abnormal_pituitary_gland | 0.66780240 |
| 97 | MP0000653_abnormal_sex_gland | 0.66139337 |
| 98 | MP0001819_abnormal_immune_cell | 0.66123122 |
| 99 | MP0002693_abnormal_pancreas_physiology | 0.66046826 |
| 100 | MP0000627_abnormal_mammary_gland | 0.65475410 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.43688721 |
| 2 | Stomatitis (HP:0010280) | 4.29579533 |
| 3 | Increased CSF lactate (HP:0002490) | 4.06085835 |
| 4 | Increased hepatocellular lipid droplets (HP:0006565) | 3.92856987 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.88211898 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.84947352 |
| 7 | Acute encephalopathy (HP:0006846) | 3.82676309 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.63898313 |
| 9 | IgG deficiency (HP:0004315) | 3.61275363 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 3.56278238 |
| 11 | Increased serum lactate (HP:0002151) | 3.29262176 |
| 12 | Abnormality of the pons (HP:0007361) | 3.28576914 |
| 13 | Methylmalonic acidemia (HP:0002912) | 3.05136809 |
| 14 | Cerebral edema (HP:0002181) | 3.01861375 |
| 15 | Hepatocellular necrosis (HP:0001404) | 2.95212654 |
| 16 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.86138284 |
| 17 | Hepatic necrosis (HP:0002605) | 2.80667672 |
| 18 | Methylmalonic aciduria (HP:0012120) | 2.76194720 |
| 19 | Abnormality of T cell physiology (HP:0011840) | 2.72991661 |
| 20 | Abnormality of the ileum (HP:0001549) | 2.72136901 |
| 21 | Meckel diverticulum (HP:0002245) | 2.70702214 |
| 22 | Hypoplasia of the pons (HP:0012110) | 2.67721064 |
| 23 | Renal Fanconi syndrome (HP:0001994) | 2.66738556 |
| 24 | 3-Methylglutaconic aciduria (HP:0003535) | 2.65543213 |
| 25 | Increased IgM level (HP:0003496) | 2.65257311 |
| 26 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.58015007 |
| 27 | Oral leukoplakia (HP:0002745) | 2.55664153 |
| 28 | Exertional dyspnea (HP:0002875) | 2.47781742 |
| 29 | Leukodystrophy (HP:0002415) | 2.47345658 |
| 30 | Lactic acidosis (HP:0003128) | 2.47259427 |
| 31 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.46611897 |
| 32 | IgA deficiency (HP:0002720) | 2.46151292 |
| 33 | Abnormality of alanine metabolism (HP:0010916) | 2.45682319 |
| 34 | Hyperalaninemia (HP:0003348) | 2.45682319 |
| 35 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.45682319 |
| 36 | Duplicated collecting system (HP:0000081) | 2.44900448 |
| 37 | Congenital, generalized hypertrichosis (HP:0004540) | 2.38673942 |
| 38 | Optic disc pallor (HP:0000543) | 2.36201385 |
| 39 | Exercise intolerance (HP:0003546) | 2.35651804 |
| 40 | Aplastic anemia (HP:0001915) | 2.32865582 |
| 41 | Increased intramyocellular lipid droplets (HP:0012240) | 2.32727650 |
| 42 | Pendular nystagmus (HP:0012043) | 2.31888318 |
| 43 | Microvesicular hepatic steatosis (HP:0001414) | 2.30635141 |
| 44 | Chromsome breakage (HP:0040012) | 2.29953520 |
| 45 | Abnormality of the renal collecting system (HP:0004742) | 2.26744382 |
| 46 | Pancytopenia (HP:0001876) | 2.26019588 |
| 47 | Respiratory difficulties (HP:0002880) | 2.25820685 |
| 48 | Testicular atrophy (HP:0000029) | 2.25100896 |
| 49 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.20996358 |
| 50 | Abnormality of T cells (HP:0002843) | 2.19590640 |
| 51 | Abnormality of the preputium (HP:0100587) | 2.19401021 |
| 52 | Colon cancer (HP:0003003) | 2.19138940 |
| 53 | Multiple enchondromatosis (HP:0005701) | 2.18218995 |
| 54 | Lethargy (HP:0001254) | 2.16704573 |
| 55 | Large for gestational age (HP:0001520) | 2.16593973 |
| 56 | Abnormality of DNA repair (HP:0003254) | 2.15132944 |
| 57 | Abnormality of the labia minora (HP:0012880) | 2.14979386 |
| 58 | Increased serum pyruvate (HP:0003542) | 2.13087241 |
| 59 | Abnormality of the anterior horn cell (HP:0006802) | 2.12965353 |
| 60 | Degeneration of anterior horn cells (HP:0002398) | 2.12965353 |
| 61 | Congenital stationary night blindness (HP:0007642) | 2.12233244 |
| 62 | Respiratory failure (HP:0002878) | 2.11663400 |
| 63 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.07989904 |
| 64 | Abnormality of methionine metabolism (HP:0010901) | 2.03209783 |
| 65 | Cerebral hypomyelination (HP:0006808) | 1.99514083 |
| 66 | Duodenal stenosis (HP:0100867) | 1.98090953 |
| 67 | Small intestinal stenosis (HP:0012848) | 1.98090953 |
| 68 | Pancreatic cysts (HP:0001737) | 1.96586263 |
| 69 | Horseshoe kidney (HP:0000085) | 1.96488851 |
| 70 | B lymphocytopenia (HP:0010976) | 1.96092874 |
| 71 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.95905704 |
| 72 | Hypoproteinemia (HP:0003075) | 1.95765106 |
| 73 | Abnormality of B cell number (HP:0010975) | 1.94986988 |
| 74 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.91075494 |
| 75 | Severe combined immunodeficiency (HP:0004430) | 1.90110601 |
| 76 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.90097541 |
| 77 | Entropion (HP:0000621) | 1.88388739 |
| 78 | Abnormality of midbrain morphology (HP:0002418) | 1.88376789 |
| 79 | Molar tooth sign on MRI (HP:0002419) | 1.88376789 |
| 80 | Dyschromatopsia (HP:0007641) | 1.88117973 |
| 81 | Abnormality of chromosome stability (HP:0003220) | 1.87122580 |
| 82 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.86203095 |
| 83 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.86203095 |
| 84 | Ketoacidosis (HP:0001993) | 1.84743833 |
| 85 | Abnormality of serum amino acid levels (HP:0003112) | 1.83365527 |
| 86 | CNS hypomyelination (HP:0003429) | 1.83286437 |
| 87 | Increased muscle lipid content (HP:0009058) | 1.82135856 |
| 88 | Opisthotonus (HP:0002179) | 1.80589093 |
| 89 | Abnormality of glycolysis (HP:0004366) | 1.78929529 |
| 90 | CNS demyelination (HP:0007305) | 1.78498333 |
| 91 | Hyperglycinemia (HP:0002154) | 1.77941589 |
| 92 | Nephronophthisis (HP:0000090) | 1.76888307 |
| 93 | Glycosuria (HP:0003076) | 1.75625379 |
| 94 | Abnormality of urine glucose concentration (HP:0011016) | 1.75625379 |
| 95 | Autoimmune hemolytic anemia (HP:0001890) | 1.74538660 |
| 96 | Abnormality of vitamin B metabolism (HP:0004340) | 1.74300604 |
| 97 | Central scotoma (HP:0000603) | 1.72932713 |
| 98 | Neutropenia (HP:0001875) | 1.71305811 |
| 99 | Abnormality of the renal cortex (HP:0011035) | 1.70727957 |
| 100 | Clubbing of toes (HP:0100760) | 1.69817191 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 5.98495820 |
| 2 | EIF2AK3 | 4.23172584 |
| 3 | EIF2AK1 | 3.92669110 |
| 4 | MST4 | 3.59090963 |
| 5 | VRK2 | 3.23278779 |
| 6 | BUB1 | 3.01080493 |
| 7 | PBK | 2.91500912 |
| 8 | NEK1 | 2.57682645 |
| 9 | SRPK1 | 2.48241123 |
| 10 | NUAK1 | 2.38284137 |
| 11 | PLK3 | 2.35971809 |
| 12 | ZAK | 2.34764307 |
| 13 | VRK1 | 1.98430808 |
| 14 | NME1 | 1.98211576 |
| 15 | TAF1 | 1.91625700 |
| 16 | STK16 | 1.89398578 |
| 17 | MKNK2 | 1.81355570 |
| 18 | TLK1 | 1.74529876 |
| 19 | WNK4 | 1.69969324 |
| 20 | ADRBK2 | 1.60804845 |
| 21 | TAOK3 | 1.57337663 |
| 22 | EIF2AK2 | 1.49215680 |
| 23 | STK39 | 1.48495201 |
| 24 | TRIM28 | 1.46463376 |
| 25 | MKNK1 | 1.41985154 |
| 26 | TXK | 1.41603788 |
| 27 | ALK | 1.33993387 |
| 28 | CDC7 | 1.32912747 |
| 29 | GRK1 | 1.32603129 |
| 30 | PASK | 1.32229371 |
| 31 | MAP2K6 | 1.23691357 |
| 32 | OXSR1 | 1.22111515 |
| 33 | PLK4 | 1.19547882 |
| 34 | TTK | 1.15609504 |
| 35 | MAPKAPK3 | 1.13358455 |
| 36 | MAPKAPK5 | 1.06801048 |
| 37 | FRK | 1.06005414 |
| 38 | PDK2 | 1.04067890 |
| 39 | TEC | 0.99152065 |
| 40 | PLK2 | 0.95291098 |
| 41 | WEE1 | 0.93490692 |
| 42 | PLK1 | 0.92695934 |
| 43 | BMPR1B | 0.91828347 |
| 44 | NME2 | 0.88590446 |
| 45 | ATR | 0.84646132 |
| 46 | BCR | 0.84568353 |
| 47 | CSNK1G1 | 0.78668788 |
| 48 | DAPK1 | 0.76868605 |
| 49 | WNK3 | 0.75257218 |
| 50 | TNIK | 0.73431392 |
| 51 | ITK | 0.73096558 |
| 52 | CSNK1G3 | 0.72030640 |
| 53 | CSNK1A1L | 0.69700972 |
| 54 | AURKB | 0.66189811 |
| 55 | IKBKB | 0.63762158 |
| 56 | STK4 | 0.59659325 |
| 57 | DYRK2 | 0.59292724 |
| 58 | CSNK1G2 | 0.57936899 |
| 59 | NLK | 0.57121681 |
| 60 | INSRR | 0.53731247 |
| 61 | BCKDK | 0.51844728 |
| 62 | RPS6KB2 | 0.50535505 |
| 63 | MAP3K14 | 0.49178545 |
| 64 | TGFBR1 | 0.48181648 |
| 65 | PINK1 | 0.47216305 |
| 66 | CSNK2A2 | 0.46860149 |
| 67 | CHEK1 | 0.46859551 |
| 68 | RPS6KA5 | 0.46015934 |
| 69 | CSNK1E | 0.45861202 |
| 70 | ACVR1B | 0.44582835 |
| 71 | MAP3K12 | 0.42881420 |
| 72 | ATM | 0.42793501 |
| 73 | PAK4 | 0.42526043 |
| 74 | CHEK2 | 0.42386887 |
| 75 | KIT | 0.40768250 |
| 76 | CSNK2A1 | 0.40701194 |
| 77 | PRKCI | 0.39661724 |
| 78 | CLK1 | 0.39291267 |
| 79 | NEK2 | 0.38331908 |
| 80 | FLT3 | 0.35601420 |
| 81 | BRSK2 | 0.35403143 |
| 82 | CDK7 | 0.34899466 |
| 83 | PNCK | 0.33588388 |
| 84 | GRK5 | 0.30434248 |
| 85 | STK3 | 0.27426767 |
| 86 | FGFR1 | 0.27270965 |
| 87 | STK38L | 0.26286651 |
| 88 | CSNK1A1 | 0.25229015 |
| 89 | SMG1 | 0.22916450 |
| 90 | PAK3 | 0.21161320 |
| 91 | TIE1 | 0.20560394 |
| 92 | PIK3CG | 0.20318296 |
| 93 | PRKCG | 0.20138960 |
| 94 | AKT3 | 0.20117993 |
| 95 | AURKA | 0.19623363 |
| 96 | RPS6KA4 | 0.19105004 |
| 97 | CDK1 | 0.18127144 |
| 98 | PRKCE | 0.17952603 |
| 99 | CAMKK2 | 0.17685615 |
| 100 | MAP4K2 | 0.17673539 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.16542304 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.06256653 |
| 3 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.85812066 |
| 4 | Protein export_Homo sapiens_hsa03060 | 2.74143618 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.73186636 |
| 6 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.48790568 |
| 7 | DNA replication_Homo sapiens_hsa03030 | 2.42132481 |
| 8 | Asthma_Homo sapiens_hsa05310 | 2.36563724 |
| 9 | RNA transport_Homo sapiens_hsa03013 | 2.28037871 |
| 10 | Allograft rejection_Homo sapiens_hsa05330 | 2.20566119 |
| 11 | Mismatch repair_Homo sapiens_hsa03430 | 2.20204557 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.17351776 |
| 13 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.11962620 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.08708206 |
| 15 | RNA degradation_Homo sapiens_hsa03018 | 2.08583976 |
| 16 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.01664850 |
| 17 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.97414093 |
| 18 | Homologous recombination_Homo sapiens_hsa03440 | 1.94967619 |
| 19 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.92858353 |
| 20 | Spliceosome_Homo sapiens_hsa03040 | 1.89607992 |
| 21 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.83334325 |
| 22 | Ribosome_Homo sapiens_hsa03010 | 1.81319047 |
| 23 | Parkinsons disease_Homo sapiens_hsa05012 | 1.77247643 |
| 24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.71627764 |
| 25 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.67492477 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.56954313 |
| 27 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.54372139 |
| 28 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.53966093 |
| 29 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.53202799 |
| 30 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.43833684 |
| 31 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.36783519 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.35919675 |
| 33 | Base excision repair_Homo sapiens_hsa03410 | 1.32429315 |
| 34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.31389612 |
| 35 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.27467838 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.25446183 |
| 37 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.22946856 |
| 38 | Huntingtons disease_Homo sapiens_hsa05016 | 1.20752379 |
| 39 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.11919443 |
| 40 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.09051495 |
| 41 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.05666094 |
| 42 | Alzheimers disease_Homo sapiens_hsa05010 | 0.97505302 |
| 43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.97306996 |
| 44 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.88526545 |
| 45 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.87812316 |
| 46 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.83456486 |
| 47 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.81159963 |
| 48 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.78816820 |
| 49 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.78347565 |
| 50 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.77764491 |
| 51 | Phototransduction_Homo sapiens_hsa04744 | 0.73726147 |
| 52 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.72406996 |
| 53 | Cell cycle_Homo sapiens_hsa04110 | 0.72376294 |
| 54 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.71829753 |
| 55 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.71453036 |
| 56 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.68965842 |
| 57 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.66551287 |
| 58 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.65290689 |
| 59 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.60386911 |
| 60 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.60059783 |
| 61 | Peroxisome_Homo sapiens_hsa04146 | 0.58121099 |
| 62 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.56474468 |
| 63 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.55938947 |
| 64 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.55834591 |
| 65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.54326255 |
| 66 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.53683998 |
| 67 | Measles_Homo sapiens_hsa05162 | 0.52559883 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.51225835 |
| 69 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.49640306 |
| 70 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.49308542 |
| 71 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.48300585 |
| 72 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.47495443 |
| 73 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.47475922 |
| 74 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.43966174 |
| 75 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.43828833 |
| 76 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.43522042 |
| 77 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.42428402 |
| 78 | Carbon metabolism_Homo sapiens_hsa01200 | 0.42370201 |
| 79 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.40262587 |
| 80 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.39317941 |
| 81 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.39098486 |
| 82 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.36646333 |
| 83 | Legionellosis_Homo sapiens_hsa05134 | 0.36285170 |
| 84 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.34250574 |
| 85 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.32586422 |
| 86 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.32088824 |
| 87 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.31595522 |
| 88 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.30449922 |
| 89 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.29806716 |
| 90 | Retinol metabolism_Homo sapiens_hsa00830 | 0.29053128 |
| 91 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.28934582 |
| 92 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.28858880 |
| 93 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.27985837 |
| 94 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.27738014 |
| 95 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.27152369 |
| 96 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.24437430 |
| 97 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.23183975 |
| 98 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.22435402 |
| 99 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.20622390 |
| 100 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.20326521 |

