NPM1P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.11399760
2DNA deamination (GO:0045006)4.84548089
3ribosome assembly (GO:0042255)4.63584483
4rRNA modification (GO:0000154)4.54912765
5regulation of isotype switching to IgG isotypes (GO:0048302)4.50611942
6regulation of immunoglobulin secretion (GO:0051023)4.37097462
7rRNA methylation (GO:0031167)4.21757223
8positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.19615904
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.11175977
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.05130779
11pseudouridine synthesis (GO:0001522)3.86168994
12regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.83715133
13regulation of cellular amino acid metabolic process (GO:0006521)3.83156602
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.81273558
15water-soluble vitamin biosynthetic process (GO:0042364)3.80261839
16somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.80079729
17isotype switching (GO:0045190)3.80079729
18somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.80079729
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79068339
20IMP biosynthetic process (GO:0006188)3.78676671
21maturation of 5.8S rRNA (GO:0000460)3.78456110
22signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.76880685
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.76880685
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.76880685
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.74055232
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.74055232
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.73660262
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68662724
29negative regulation of ligase activity (GO:0051352)3.68662724
30tRNA aminoacylation (GO:0043039)3.67803752
31amino acid activation (GO:0043038)3.67803752
32regulation of chronic inflammatory response (GO:0002676)3.65779697
33signal transduction involved in DNA integrity checkpoint (GO:0072401)3.64502262
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.64502262
35transcription elongation from RNA polymerase I promoter (GO:0006362)3.62818244
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.61859592
37tRNA aminoacylation for protein translation (GO:0006418)3.59608608
38ribosome biogenesis (GO:0042254)3.59486881
39cullin deneddylation (GO:0010388)3.57686859
40mitochondrial respiratory chain complex assembly (GO:0033108)3.57404933
41rRNA processing (GO:0006364)3.57392330
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.56362908
43positive regulation of isotype switching (GO:0045830)3.53507129
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52270699
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.51007967
46termination of RNA polymerase I transcription (GO:0006363)3.47926659
47rRNA metabolic process (GO:0016072)3.45557141
48protein complex biogenesis (GO:0070271)3.44430071
49positive regulation of immune response to tumor cell (GO:0002839)3.44254862
50regulation of immune response to tumor cell (GO:0002837)3.44254862
51regulation of response to tumor cell (GO:0002834)3.44254862
52positive regulation of response to tumor cell (GO:0002836)3.44254862
53positive regulation of DNA recombination (GO:0045911)3.43822810
54DNA catabolic process, exonucleolytic (GO:0000738)3.41859958
55regulation of regulatory T cell differentiation (GO:0045589)3.40709070
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38900061
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.38900061
58NADH dehydrogenase complex assembly (GO:0010257)3.38900061
59folic acid-containing compound biosynthetic process (GO:0009396)3.37472912
60purine nucleobase biosynthetic process (GO:0009113)3.37049941
61mitochondrial RNA metabolic process (GO:0000959)3.34042983
62transcription from mitochondrial promoter (GO:0006390)3.32115690
63DNA double-strand break processing (GO:0000729)3.31902519
64protein deneddylation (GO:0000338)3.31527521
65nucleobase biosynthetic process (GO:0046112)3.31154405
66protein neddylation (GO:0045116)3.29526858
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28011587
68formation of translation preinitiation complex (GO:0001731)3.24175332
69ribosomal large subunit biogenesis (GO:0042273)3.21605608
70somatic diversification of immunoglobulins (GO:0016445)3.20653322
71IMP metabolic process (GO:0046040)3.19812153
72transcription elongation from RNA polymerase III promoter (GO:0006385)3.19744872
73termination of RNA polymerase III transcription (GO:0006386)3.19744872
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18945498
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18945498
76somatic recombination of immunoglobulin gene segments (GO:0016447)3.17779140
77positive regulation of ligase activity (GO:0051351)3.16493855
78tRNA metabolic process (GO:0006399)3.16436606
79respiratory chain complex IV assembly (GO:0008535)3.04756346
80ncRNA metabolic process (GO:0034660)3.03332124
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.01068066
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.01048903
83positive regulation of cell cycle arrest (GO:0071158)2.98939146
84chaperone-mediated protein transport (GO:0072321)2.98245534
85tRNA processing (GO:0008033)2.97334315
86energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95878533
87ATP synthesis coupled proton transport (GO:0015986)2.95878533
88transcription initiation from RNA polymerase I promoter (GO:0006361)2.93913482
89spliceosomal snRNP assembly (GO:0000387)2.93849063
90ribonucleoprotein complex biogenesis (GO:0022613)2.93499663
91cellular component biogenesis (GO:0044085)2.93292071
92ncRNA processing (GO:0034470)2.91304797
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90964745
94DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.86291639
95DNA replication checkpoint (GO:0000076)2.85796282
96protein targeting to mitochondrion (GO:0006626)2.85393239
97DNA damage response, detection of DNA damage (GO:0042769)2.84310053
98GTP biosynthetic process (GO:0006183)2.84142554
99regulation of ubiquitin-protein transferase activity (GO:0051438)2.82072170
100transcription from RNA polymerase I promoter (GO:0006360)2.81615960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.46024180
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.80958441
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.40409399
4E2F7_22180533_ChIP-Seq_HELA_Human4.38355545
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.17703545
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52390649
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.41774059
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.27350930
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20721906
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.09208438
11VDR_23849224_ChIP-Seq_CD4+_Human2.99024222
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87916115
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78635611
14ELK1_19687146_ChIP-ChIP_HELA_Human2.72433665
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52290691
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.51935858
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50947274
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50527028
19FOXP3_21729870_ChIP-Seq_TREG_Human2.49090781
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30300540
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25107476
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24218746
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.07257935
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03713266
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99064848
26DCP1A_22483619_ChIP-Seq_HELA_Human1.97957215
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97293306
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.93441395
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89630644
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89136030
31TTF2_22483619_ChIP-Seq_HELA_Human1.85547900
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83855024
33VDR_22108803_ChIP-Seq_LS180_Human1.78646682
34GABP_19822575_ChIP-Seq_HepG2_Human1.76848025
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71858029
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.71410532
37EWS_26573619_Chip-Seq_HEK293_Human1.69633885
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66797921
39XRN2_22483619_ChIP-Seq_HELA_Human1.65335679
40ZNF274_21170338_ChIP-Seq_K562_Hela1.64402544
41MYC_18940864_ChIP-ChIP_HL60_Human1.63893925
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62126541
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61466277
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60976799
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57369565
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.53898737
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50043187
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45213750
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45010911
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42129083
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40911296
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34594979
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31737779
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.26949289
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26181014
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22570790
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.18787677
58KDM5A_27292631_Chip-Seq_BREAST_Human1.17297690
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.17026598
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16406173
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13736107
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12787939
63TP53_22573176_ChIP-Seq_HFKS_Human1.12693656
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12156556
65FUS_26573619_Chip-Seq_HEK293_Human1.08441180
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06824108
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03801563
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98894046
69AR_21909140_ChIP-Seq_LNCAP_Human0.97736415
70FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97050720
71FOXA1_25329375_ChIP-Seq_VCAP_Human0.97050720
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95977781
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94475845
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93735255
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92623887
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91435559
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88763222
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88268782
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86817497
80NFE2_27457419_Chip-Seq_LIVER_Mouse0.86414123
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86033915
82GATA3_26560356_Chip-Seq_TH2_Human0.85929880
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85554309
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84286948
85LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83923226
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83678726
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83186179
88IRF1_19129219_ChIP-ChIP_H3396_Human0.81107854
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80624168
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80537103
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79529319
92NANOG_19829295_ChIP-Seq_ESCs_Human0.78732826
93SOX2_19829295_ChIP-Seq_ESCs_Human0.78732826
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78227653
95P300_19829295_ChIP-Seq_ESCs_Human0.77654540
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77235217
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75888702
98ER_23166858_ChIP-Seq_MCF-7_Human0.72980840
99ELF5_23300383_ChIP-Seq_T47D_Human0.72539019
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72316484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.62293870
2MP0008057_abnormal_DNA_replication3.40429584
3MP0001835_abnormal_antigen_presentation3.37482419
4MP0003693_abnormal_embryo_hatching3.31717884
5MP0010094_abnormal_chromosome_stability3.20609939
6MP0001348_abnormal_lacrimal_gland3.07378605
7MP0002102_abnormal_ear_morphology2.95981215
8MP0000685_abnormal_immune_system2.82630460
9MP0004957_abnormal_blastocyst_morpholog2.78924767
10MP0003786_premature_aging2.67917468
11MP0003718_maternal_effect2.60988346
12MP0001873_stomach_inflammation2.32299388
13MP0003806_abnormal_nucleotide_metabolis2.31323225
14MP0008872_abnormal_physiological_respon2.29257180
15MP0008007_abnormal_cellular_replicative2.26167463
16MP0004147_increased_porphyrin_level2.20582236
17MP0003077_abnormal_cell_cycle2.09024504
18MP0006036_abnormal_mitochondrial_physio2.03064407
19MP0006035_abnormal_mitochondrial_morpho1.95970935
20MP0005671_abnormal_response_to1.93172568
21MP0003111_abnormal_nucleus_morphology1.90630329
22MP0009333_abnormal_splenocyte_physiolog1.82266155
23MP0002138_abnormal_hepatobiliary_system1.79295703
24MP0001790_abnormal_immune_system1.76315789
25MP0005387_immune_system_phenotype1.76315789
26MP0008875_abnormal_xenobiotic_pharmacok1.75877300
27MP0002163_abnormal_gland_morphology1.69649621
28MP0002006_tumorigenesis1.64269886
29MP0003567_abnormal_fetal_cardiomyocyte1.61125726
30MP0003646_muscle_fatigue1.60005489
31MP0008877_abnormal_DNA_methylation1.51278358
32MP0005084_abnormal_gallbladder_morpholo1.50362902
33MP0005379_endocrine/exocrine_gland_phen1.49126757
34MP0004782_abnormal_surfactant_physiolog1.48305398
35MP0000372_irregular_coat_pigmentation1.47845290
36MP0001529_abnormal_vocalization1.43631023
37MP0003763_abnormal_thymus_physiology1.43193661
38MP0005075_abnormal_melanosome_morpholog1.42893349
39MP0002166_altered_tumor_susceptibility1.41785521
40MP0002837_dystrophic_cardiac_calcinosis1.38065301
41MP0009785_altered_susceptibility_to1.36799588
42MP0006072_abnormal_retinal_apoptosis1.35182442
43MP0006292_abnormal_olfactory_placode1.33320349
44MP0005310_abnormal_salivary_gland1.29561778
45MP0001800_abnormal_humoral_immune1.26084635
46MP0001293_anophthalmia1.25484336
47MP0002148_abnormal_hypersensitivity_rea1.25161775
48MP0003186_abnormal_redox_activity1.24972726
49MP0000569_abnormal_digit_pigmentation1.22058440
50MP0008932_abnormal_embryonic_tissue1.21092459
51MP0004145_abnormal_muscle_electrophysio1.18956029
52MP0005645_abnormal_hypothalamus_physiol1.18731392
53MP0005408_hypopigmentation1.17701351
54MP0001853_heart_inflammation1.17580672
55MP0002277_abnormal_respiratory_mucosa1.13452641
56MP0004142_abnormal_muscle_tone1.13146459
57MP0001188_hyperpigmentation1.01085550
58MP0005174_abnormal_tail_pigmentation1.00976927
59MP0009697_abnormal_copulation1.00966820
60MP0000689_abnormal_spleen_morphology0.99938181
61MP0005389_reproductive_system_phenotype0.98440070
62MP0005000_abnormal_immune_tolerance0.97262579
63MP0002160_abnormal_reproductive_system0.97033323
64MP0002736_abnormal_nociception_after0.96482882
65MP0002398_abnormal_bone_marrow0.94322656
66MP0000703_abnormal_thymus_morphology0.93989052
67MP0002405_respiratory_system_inflammati0.92266685
68MP0002396_abnormal_hematopoietic_system0.90605417
69MP0001968_abnormal_touch/_nociception0.88652248
70MP0001919_abnormal_reproductive_system0.88091880
71MP0002019_abnormal_tumor_incidence0.87667397
72MP0005410_abnormal_fertilization0.87149501
73MP0002210_abnormal_sex_determination0.87061679
74MP0001881_abnormal_mammary_gland0.84600524
75MP0001929_abnormal_gametogenesis0.83268941
76MP0000490_abnormal_crypts_of0.81608997
77MP0001986_abnormal_taste_sensitivity0.79939189
78MP0002722_abnormal_immune_system0.77739261
79MP0001661_extended_life_span0.77105558
80MP0001501_abnormal_sleep_pattern0.76870187
81MP0002938_white_spotting0.76026379
82MP0003936_abnormal_reproductive_system0.75202978
83MP0002751_abnormal_autonomic_nervous0.74197030
84MP0000313_abnormal_cell_death0.73814766
85MP0002723_abnormal_immune_serum0.73504570
86MP0002429_abnormal_blood_cell0.71616738
87MP0000358_abnormal_cell_content/0.71397363
88MP0001764_abnormal_homeostasis0.70863231
89MP0001119_abnormal_female_reproductive0.70863120
90MP0002452_abnormal_antigen_presenting0.69961945
91MP0002420_abnormal_adaptive_immunity0.69765764
92MP0004215_abnormal_myocardial_fiber0.68690309
93MP0001697_abnormal_embryo_size0.67446181
94MP0003195_calcinosis0.67276388
95MP0008995_early_reproductive_senescence0.67054131
96MP0005646_abnormal_pituitary_gland0.66780240
97MP0000653_abnormal_sex_gland0.66139337
98MP0001819_abnormal_immune_cell0.66123122
99MP0002693_abnormal_pancreas_physiology0.66046826
100MP0000627_abnormal_mammary_gland0.65475410

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.43688721
2Stomatitis (HP:0010280)4.29579533
3Increased CSF lactate (HP:0002490)4.06085835
4Increased hepatocellular lipid droplets (HP:0006565)3.92856987
5Abnormal mitochondria in muscle tissue (HP:0008316)3.88211898
6Mitochondrial inheritance (HP:0001427)3.84947352
7Acute encephalopathy (HP:0006846)3.82676309
8Progressive macrocephaly (HP:0004481)3.63898313
9IgG deficiency (HP:0004315)3.61275363
10Lipid accumulation in hepatocytes (HP:0006561)3.56278238
11Increased serum lactate (HP:0002151)3.29262176
12Abnormality of the pons (HP:0007361)3.28576914
13Methylmalonic acidemia (HP:0002912)3.05136809
14Cerebral edema (HP:0002181)3.01861375
15Hepatocellular necrosis (HP:0001404)2.95212654
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86138284
17Hepatic necrosis (HP:0002605)2.80667672
18Methylmalonic aciduria (HP:0012120)2.76194720
19Abnormality of T cell physiology (HP:0011840)2.72991661
20Abnormality of the ileum (HP:0001549)2.72136901
21Meckel diverticulum (HP:0002245)2.70702214
22Hypoplasia of the pons (HP:0012110)2.67721064
23Renal Fanconi syndrome (HP:0001994)2.66738556
243-Methylglutaconic aciduria (HP:0003535)2.65543213
25Increased IgM level (HP:0003496)2.65257311
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.58015007
27Oral leukoplakia (HP:0002745)2.55664153
28Exertional dyspnea (HP:0002875)2.47781742
29Leukodystrophy (HP:0002415)2.47345658
30Lactic acidosis (HP:0003128)2.47259427
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46611897
32IgA deficiency (HP:0002720)2.46151292
33Abnormality of alanine metabolism (HP:0010916)2.45682319
34Hyperalaninemia (HP:0003348)2.45682319
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45682319
36Duplicated collecting system (HP:0000081)2.44900448
37Congenital, generalized hypertrichosis (HP:0004540)2.38673942
38Optic disc pallor (HP:0000543)2.36201385
39Exercise intolerance (HP:0003546)2.35651804
40Aplastic anemia (HP:0001915)2.32865582
41Increased intramyocellular lipid droplets (HP:0012240)2.32727650
42Pendular nystagmus (HP:0012043)2.31888318
43Microvesicular hepatic steatosis (HP:0001414)2.30635141
44Chromsome breakage (HP:0040012)2.29953520
45Abnormality of the renal collecting system (HP:0004742)2.26744382
46Pancytopenia (HP:0001876)2.26019588
47Respiratory difficulties (HP:0002880)2.25820685
48Testicular atrophy (HP:0000029)2.25100896
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.20996358
50Abnormality of T cells (HP:0002843)2.19590640
51Abnormality of the preputium (HP:0100587)2.19401021
52Colon cancer (HP:0003003)2.19138940
53Multiple enchondromatosis (HP:0005701)2.18218995
54Lethargy (HP:0001254)2.16704573
55Large for gestational age (HP:0001520)2.16593973
56Abnormality of DNA repair (HP:0003254)2.15132944
57Abnormality of the labia minora (HP:0012880)2.14979386
58Increased serum pyruvate (HP:0003542)2.13087241
59Abnormality of the anterior horn cell (HP:0006802)2.12965353
60Degeneration of anterior horn cells (HP:0002398)2.12965353
61Congenital stationary night blindness (HP:0007642)2.12233244
62Respiratory failure (HP:0002878)2.11663400
63Aplasia/hypoplasia of the uterus (HP:0008684)2.07989904
64Abnormality of methionine metabolism (HP:0010901)2.03209783
65Cerebral hypomyelination (HP:0006808)1.99514083
66Duodenal stenosis (HP:0100867)1.98090953
67Small intestinal stenosis (HP:0012848)1.98090953
68Pancreatic cysts (HP:0001737)1.96586263
69Horseshoe kidney (HP:0000085)1.96488851
70B lymphocytopenia (HP:0010976)1.96092874
71Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95905704
72Hypoproteinemia (HP:0003075)1.95765106
73Abnormality of B cell number (HP:0010975)1.94986988
74Abnormality of the vitamin B12 metabolism (HP:0004341)1.91075494
75Severe combined immunodeficiency (HP:0004430)1.90110601
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90097541
77Entropion (HP:0000621)1.88388739
78Abnormality of midbrain morphology (HP:0002418)1.88376789
79Molar tooth sign on MRI (HP:0002419)1.88376789
80Dyschromatopsia (HP:0007641)1.88117973
81Abnormality of chromosome stability (HP:0003220)1.87122580
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86203095
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86203095
84Ketoacidosis (HP:0001993)1.84743833
85Abnormality of serum amino acid levels (HP:0003112)1.83365527
86CNS hypomyelination (HP:0003429)1.83286437
87Increased muscle lipid content (HP:0009058)1.82135856
88Opisthotonus (HP:0002179)1.80589093
89Abnormality of glycolysis (HP:0004366)1.78929529
90CNS demyelination (HP:0007305)1.78498333
91Hyperglycinemia (HP:0002154)1.77941589
92Nephronophthisis (HP:0000090)1.76888307
93Glycosuria (HP:0003076)1.75625379
94Abnormality of urine glucose concentration (HP:0011016)1.75625379
95Autoimmune hemolytic anemia (HP:0001890)1.74538660
96Abnormality of vitamin B metabolism (HP:0004340)1.74300604
97Central scotoma (HP:0000603)1.72932713
98Neutropenia (HP:0001875)1.71305811
99Abnormality of the renal cortex (HP:0011035)1.70727957
100Clubbing of toes (HP:0100760)1.69817191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.98495820
2EIF2AK34.23172584
3EIF2AK13.92669110
4MST43.59090963
5VRK23.23278779
6BUB13.01080493
7PBK2.91500912
8NEK12.57682645
9SRPK12.48241123
10NUAK12.38284137
11PLK32.35971809
12ZAK2.34764307
13VRK11.98430808
14NME11.98211576
15TAF11.91625700
16STK161.89398578
17MKNK21.81355570
18TLK11.74529876
19WNK41.69969324
20ADRBK21.60804845
21TAOK31.57337663
22EIF2AK21.49215680
23STK391.48495201
24TRIM281.46463376
25MKNK11.41985154
26TXK1.41603788
27ALK1.33993387
28CDC71.32912747
29GRK11.32603129
30PASK1.32229371
31MAP2K61.23691357
32OXSR11.22111515
33PLK41.19547882
34TTK1.15609504
35MAPKAPK31.13358455
36MAPKAPK51.06801048
37FRK1.06005414
38PDK21.04067890
39TEC0.99152065
40PLK20.95291098
41WEE10.93490692
42PLK10.92695934
43BMPR1B0.91828347
44NME20.88590446
45ATR0.84646132
46BCR0.84568353
47CSNK1G10.78668788
48DAPK10.76868605
49WNK30.75257218
50TNIK0.73431392
51ITK0.73096558
52CSNK1G30.72030640
53CSNK1A1L0.69700972
54AURKB0.66189811
55IKBKB0.63762158
56STK40.59659325
57DYRK20.59292724
58CSNK1G20.57936899
59NLK0.57121681
60INSRR0.53731247
61BCKDK0.51844728
62RPS6KB20.50535505
63MAP3K140.49178545
64TGFBR10.48181648
65PINK10.47216305
66CSNK2A20.46860149
67CHEK10.46859551
68RPS6KA50.46015934
69CSNK1E0.45861202
70ACVR1B0.44582835
71MAP3K120.42881420
72ATM0.42793501
73PAK40.42526043
74CHEK20.42386887
75KIT0.40768250
76CSNK2A10.40701194
77PRKCI0.39661724
78CLK10.39291267
79NEK20.38331908
80FLT30.35601420
81BRSK20.35403143
82CDK70.34899466
83PNCK0.33588388
84GRK50.30434248
85STK30.27426767
86FGFR10.27270965
87STK38L0.26286651
88CSNK1A10.25229015
89SMG10.22916450
90PAK30.21161320
91TIE10.20560394
92PIK3CG0.20318296
93PRKCG0.20138960
94AKT30.20117993
95AURKA0.19623363
96RPS6KA40.19105004
97CDK10.18127144
98PRKCE0.17952603
99CAMKK20.17685615
100MAP4K20.17673539

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.16542304
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.06256653
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.85812066
4Protein export_Homo sapiens_hsa030602.74143618
5RNA polymerase_Homo sapiens_hsa030202.73186636
6One carbon pool by folate_Homo sapiens_hsa006702.48790568
7DNA replication_Homo sapiens_hsa030302.42132481
8Asthma_Homo sapiens_hsa053102.36563724
9RNA transport_Homo sapiens_hsa030132.28037871
10Allograft rejection_Homo sapiens_hsa053302.20566119
11Mismatch repair_Homo sapiens_hsa034302.20204557
12Basal transcription factors_Homo sapiens_hsa030222.17351776
13Non-homologous end-joining_Homo sapiens_hsa034502.11962620
14Nucleotide excision repair_Homo sapiens_hsa034202.08708206
15RNA degradation_Homo sapiens_hsa030182.08583976
16Autoimmune thyroid disease_Homo sapiens_hsa053202.01664850
17Oxidative phosphorylation_Homo sapiens_hsa001901.97414093
18Homologous recombination_Homo sapiens_hsa034401.94967619
19Vitamin B6 metabolism_Homo sapiens_hsa007501.92858353
20Spliceosome_Homo sapiens_hsa030401.89607992
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.83334325
22Ribosome_Homo sapiens_hsa030101.81319047
23Parkinsons disease_Homo sapiens_hsa050121.77247643
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71627764
25Primary immunodeficiency_Homo sapiens_hsa053401.67492477
26Propanoate metabolism_Homo sapiens_hsa006401.56954313
27Pyrimidine metabolism_Homo sapiens_hsa002401.54372139
28Fanconi anemia pathway_Homo sapiens_hsa034601.53966093
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53202799
30Type I diabetes mellitus_Homo sapiens_hsa049401.43833684
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36783519
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.35919675
33Base excision repair_Homo sapiens_hsa034101.32429315
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31389612
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27467838
36Purine metabolism_Homo sapiens_hsa002301.25446183
37Graft-versus-host disease_Homo sapiens_hsa053321.22946856
38Huntingtons disease_Homo sapiens_hsa050161.20752379
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11919443
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09051495
41Antigen processing and presentation_Homo sapiens_hsa046121.05666094
42Alzheimers disease_Homo sapiens_hsa050100.97505302
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97306996
44Nitrogen metabolism_Homo sapiens_hsa009100.88526545
45Pyruvate metabolism_Homo sapiens_hsa006200.87812316
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83456486
47Sulfur metabolism_Homo sapiens_hsa009200.81159963
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78816820
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78347565
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77764491
51Phototransduction_Homo sapiens_hsa047440.73726147
52Linoleic acid metabolism_Homo sapiens_hsa005910.72406996
53Cell cycle_Homo sapiens_hsa041100.72376294
54Butanoate metabolism_Homo sapiens_hsa006500.71829753
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.71453036
56mRNA surveillance pathway_Homo sapiens_hsa030150.68965842
57Caffeine metabolism_Homo sapiens_hsa002320.66551287
58Epstein-Barr virus infection_Homo sapiens_hsa051690.65290689
59Hematopoietic cell lineage_Homo sapiens_hsa046400.60386911
60Selenocompound metabolism_Homo sapiens_hsa004500.60059783
61Peroxisome_Homo sapiens_hsa041460.58121099
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56474468
63p53 signaling pathway_Homo sapiens_hsa041150.55938947
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55834591
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54326255
66T cell receptor signaling pathway_Homo sapiens_hsa046600.53683998
67Measles_Homo sapiens_hsa051620.52559883
68Metabolic pathways_Homo sapiens_hsa011000.51225835
69Rheumatoid arthritis_Homo sapiens_hsa053230.49640306
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49308542
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48300585
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.47495443
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47475922
74Regulation of autophagy_Homo sapiens_hsa041400.43966174
75Systemic lupus erythematosus_Homo sapiens_hsa053220.43828833
76Tryptophan metabolism_Homo sapiens_hsa003800.43522042
77Glutathione metabolism_Homo sapiens_hsa004800.42428402
78Carbon metabolism_Homo sapiens_hsa012000.42370201
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40262587
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39317941
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.39098486
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36646333
83Legionellosis_Homo sapiens_hsa051340.36285170
84Folate biosynthesis_Homo sapiens_hsa007900.34250574
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32586422
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32088824
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.31595522
88Fat digestion and absorption_Homo sapiens_hsa049750.30449922
89Cardiac muscle contraction_Homo sapiens_hsa042600.29806716
90Retinol metabolism_Homo sapiens_hsa008300.29053128
91Biosynthesis of amino acids_Homo sapiens_hsa012300.28934582
92Steroid biosynthesis_Homo sapiens_hsa001000.28858880
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.27985837
94beta-Alanine metabolism_Homo sapiens_hsa004100.27738014
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27152369
96Fatty acid elongation_Homo sapiens_hsa000620.24437430
97Herpes simplex infection_Homo sapiens_hsa051680.23183975
98Ether lipid metabolism_Homo sapiens_hsa005650.22435402
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20622390
100N-Glycan biosynthesis_Homo sapiens_hsa005100.20326521

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