NPM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)8.86273718
2piRNA metabolic process (GO:0034587)8.61287169
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)8.32260072
4synaptic vesicle maturation (GO:0016188)6.63563624
5mitotic metaphase plate congression (GO:0007080)6.49989467
6synaptic vesicle docking involved in exocytosis (GO:0016081)6.46798487
7glutamate secretion (GO:0014047)6.41962989
8female gamete generation (GO:0007292)6.30401457
9regulation of acrosome reaction (GO:0060046)6.26345990
10regulation of short-term neuronal synaptic plasticity (GO:0048172)6.05791876
11mitotic chromosome condensation (GO:0007076)6.01722254
12synaptic vesicle exocytosis (GO:0016079)5.92790489
13histone H2A monoubiquitination (GO:0035518)5.73026319
14DNA methylation involved in gamete generation (GO:0043046)5.48657001
15meiotic cell cycle (GO:0051321)5.40620324
16metaphase plate congression (GO:0051310)5.37557882
17attachment of spindle microtubules to kinetochore (GO:0008608)5.36660569
18negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.31673206
19negative regulation of meiosis (GO:0045835)5.27563403
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.22414581
21protein K6-linked ubiquitination (GO:0085020)5.10202661
22establishment of chromosome localization (GO:0051303)5.09359872
23histone H2A ubiquitination (GO:0033522)5.08679762
24oocyte maturation (GO:0001556)5.07316303
25regulation of meiosis I (GO:0060631)5.03086012
26male meiosis (GO:0007140)5.01095437
27* regulation of meiosis (GO:0040020)4.92259683
28L-amino acid import (GO:0043092)4.89671972
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.84490771
30regulation of synaptic vesicle exocytosis (GO:2000300)4.84254330
31mitotic sister chromatid segregation (GO:0000070)4.83654088
32regulation of calcium ion-dependent exocytosis (GO:0017158)4.81844237
33retinal cone cell development (GO:0046549)4.81191040
34neurotransmitter secretion (GO:0007269)4.80310327
35regulation of sister chromatid cohesion (GO:0007063)4.77709256
36multicellular organism reproduction (GO:0032504)4.72350607
37protein kinase C signaling (GO:0070528)4.66671862
38negative regulation of reproductive process (GO:2000242)4.52643919
39meiotic chromosome segregation (GO:0045132)4.47550708
40regulation of neuronal synaptic plasticity (GO:0048168)4.46320462
41negative regulation of smooth muscle cell differentiation (GO:0051151)4.45615531
42DNA damage induced protein phosphorylation (GO:0006975)4.43319687
43citrulline biosynthetic process (GO:0019240)4.36711412
44base-excision repair, AP site formation (GO:0006285)4.35778682
45regulation of synaptic vesicle transport (GO:1902803)4.30857266
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.30419654
47regulation of histone H3-K27 methylation (GO:0061085)4.19971749
48phosphorelay signal transduction system (GO:0000160)4.16811571
49regulation of spindle organization (GO:0090224)4.16645684
50negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.14740130
51negative regulation of DNA-templated transcription, elongation (GO:0032785)4.14740130
52positive regulation of synapse maturation (GO:0090129)4.14288780
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13156457
54microtubule severing (GO:0051013)4.11798894
55regulation of retinoic acid receptor signaling pathway (GO:0048385)4.10241337
56DNA alkylation (GO:0006305)4.07874165
57DNA methylation (GO:0006306)4.07874165
58maturation of 5.8S rRNA (GO:0000460)4.07359036
59DNA damage response, signal transduction resulting in transcription (GO:0042772)4.07343758
60notochord development (GO:0030903)4.04600632
61positive regulation of dendritic spine morphogenesis (GO:0061003)4.01129572
62regulation of female receptivity (GO:0045924)4.00690952
63gene silencing by RNA (GO:0031047)4.00568431
64histone H3-K9 demethylation (GO:0033169)4.00096413
65DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.99398068
66protein localization to chromosome, centromeric region (GO:0071459)3.98775174
67negative regulation of meiotic cell cycle (GO:0051447)3.96705765
68chromosome segregation (GO:0007059)3.95522760
69neurotransmitter transport (GO:0006836)3.94644023
70amino acid import (GO:0043090)3.94373481
71female gonad development (GO:0008585)3.91729470
72negative regulation of hormone metabolic process (GO:0032351)3.91264117
73negative regulation of hormone biosynthetic process (GO:0032353)3.91264117
74sister chromatid segregation (GO:0000819)3.89215229
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88613605
76monoubiquitinated protein deubiquitination (GO:0035520)3.88420768
77glycine transport (GO:0015816)3.88285301
78protein localization to kinetochore (GO:0034501)3.85744586
79* regulation of meiotic cell cycle (GO:0051445)3.82526718
80protein localization to chromosome (GO:0034502)3.80081079
81calcium ion-dependent exocytosis (GO:0017156)3.79871436
82glycerophospholipid catabolic process (GO:0046475)3.79793805
83cellular potassium ion homeostasis (GO:0030007)3.78169938
84regulation of mitotic spindle organization (GO:0060236)3.76176705
85regulation of long-term neuronal synaptic plasticity (GO:0048169)3.74856545
86mitotic sister chromatid cohesion (GO:0007064)3.74346018
87neurotransmitter-gated ion channel clustering (GO:0072578)3.71840340
88positive regulation of dendritic spine development (GO:0060999)3.71144786
89protein localization to synapse (GO:0035418)3.65385385
90positive regulation of chromosome segregation (GO:0051984)3.64977431
91CENP-A containing nucleosome assembly (GO:0034080)3.64570345
92spindle checkpoint (GO:0031577)3.63475272
93regulation of RIG-I signaling pathway (GO:0039535)3.62219391
94sodium ion export (GO:0071436)3.61238817
95synaptonemal complex assembly (GO:0007130)3.59831415
96positive regulation of membrane potential (GO:0045838)3.59198435
97regulation of DNA methylation (GO:0044030)3.59165738
98regulation of chromosome segregation (GO:0051983)3.59035469
99exploration behavior (GO:0035640)3.56274647
100pyrimidine nucleotide catabolic process (GO:0006244)3.55990489
101chaperone-mediated protein transport (GO:0072321)3.54649694
102ionotropic glutamate receptor signaling pathway (GO:0035235)3.53583246
103locomotory exploration behavior (GO:0035641)3.50414028
104chromatin remodeling at centromere (GO:0031055)3.48545998
105reproduction (GO:0000003)3.48456363
106DNA replication-independent nucleosome organization (GO:0034724)3.47119200
107DNA replication-independent nucleosome assembly (GO:0006336)3.47119200
108positive regulation of exocytosis (GO:0045921)3.45329154
109histone exchange (GO:0043486)3.42683243
110positive regulation of megakaryocyte differentiation (GO:0045654)3.41949081
111regulation of glutamate receptor signaling pathway (GO:1900449)3.41046367
112regulation of dendritic spine morphogenesis (GO:0061001)3.41043938
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.38340405
114regulation of transforming growth factor beta2 production (GO:0032909)3.38265254
115regulation of exocytosis (GO:0017157)3.37606148
116negative regulation of histone methylation (GO:0031061)3.37148337
117type B pancreatic cell development (GO:0003323)3.37117097
118positive regulation of histone H3-K4 methylation (GO:0051571)3.37085200
119kinetochore assembly (GO:0051382)3.36792305
120neuronal action potential propagation (GO:0019227)3.36265862
121regulation of neurotransmitter levels (GO:0001505)3.36053116
122oogenesis (GO:0048477)3.35384772
123regulation of synaptic plasticity (GO:0048167)3.34240752
124dendritic spine morphogenesis (GO:0060997)3.32674459
125DNA replication checkpoint (GO:0000076)3.31132597
126synaptic transmission, glutamatergic (GO:0035249)3.29651623
127female mating behavior (GO:0060180)3.29541822
128neuron-neuron synaptic transmission (GO:0007270)3.27312938
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.27077054
130mitotic nuclear envelope disassembly (GO:0007077)3.26880803
131sleep (GO:0030431)3.26584907
132cochlea development (GO:0090102)3.26183724
133chemosensory behavior (GO:0007635)3.25959269
134glutamate receptor signaling pathway (GO:0007215)3.25605281
135synaptonemal complex organization (GO:0070193)3.25041223
136negative regulation of cell division (GO:0051782)3.24615557
137cellular sodium ion homeostasis (GO:0006883)3.22578062
138gamma-aminobutyric acid signaling pathway (GO:0007214)3.22228971
139positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.21124690
140positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.21124690
141positive regulation of mitotic sister chromatid separation (GO:1901970)3.21124690
142regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.20756240
143negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19779238
144central nervous system myelination (GO:0022010)3.19605909
145axon ensheathment in central nervous system (GO:0032291)3.19605909
146neuromuscular process controlling posture (GO:0050884)3.19032195
147gamma-aminobutyric acid transport (GO:0015812)3.18379585
148meiotic cell cycle process (GO:1903046)3.17801050
149regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.17591003
150sister chromatid cohesion (GO:0007062)3.16486530
151membrane disassembly (GO:0030397)3.11603090
152nuclear envelope disassembly (GO:0051081)3.11603090
153positive regulation of neurotransmitter secretion (GO:0001956)3.11284175
154meiotic nuclear division (GO:0007126)3.11163428
155layer formation in cerebral cortex (GO:0021819)3.11059153
156mitotic spindle checkpoint (GO:0071174)3.10681261
157microtubule nucleation (GO:0007020)3.10119525
158histone monoubiquitination (GO:0010390)3.09575183
159synaptic vesicle endocytosis (GO:0048488)3.09163866
160regulation of synapse maturation (GO:0090128)3.08934975
161drinking behavior (GO:0042756)3.08463176
162regulation of hypersensitivity (GO:0002883)3.07466372
163regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07227322
164negative regulation of nuclear division (GO:0051784)3.06055991
165positive regulation of neurotransmitter transport (GO:0051590)3.05243504
166kinetochore organization (GO:0051383)3.04830432
167oocyte development (GO:0048599)3.04168964
168snRNA transcription (GO:0009301)3.03753751
169regulation of neurotransmitter secretion (GO:0046928)3.03507737
170positive regulation of humoral immune response (GO:0002922)3.03198239
171regulation of ARF protein signal transduction (GO:0032012)3.01838697
172cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01363169
173primary amino compound metabolic process (GO:1901160)2.99842011
174serotonin metabolic process (GO:0042428)2.99414353
175phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.97472729
176aggressive behavior (GO:0002118)2.96114477
177cerebellar granule cell differentiation (GO:0021707)2.96041200
178vocalization behavior (GO:0071625)2.92549326
179regulation of dendritic spine development (GO:0060998)2.92219725
180potassium ion import (GO:0010107)2.91520106
181dendritic spine organization (GO:0097061)2.90690422
182regulation of steroid hormone biosynthetic process (GO:0090030)2.90152534
183negative regulation of dendrite morphogenesis (GO:0050774)2.89290025
184neuronal ion channel clustering (GO:0045161)2.89278035
185regulation of postsynaptic membrane potential (GO:0060078)2.88492607
186long-term memory (GO:0007616)2.86642019
187proline transport (GO:0015824)2.82337563
188regulation of neurotransmitter transport (GO:0051588)2.81359777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.72432252
2FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.59397036
3E2F7_22180533_ChIP-Seq_HELA_Human3.90443031
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.81126093
5AR_21909140_ChIP-Seq_LNCAP_Human3.68128032
6KAP1_22055183_ChIP-Seq_ESCs_Mouse3.66718225
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.32216057
8REST_21632747_ChIP-Seq_MESCs_Mouse3.08272144
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.99469764
10DROSHA_22980978_ChIP-Seq_HELA_Human2.71803175
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65595083
12GBX2_23144817_ChIP-Seq_PC3_Human2.60656666
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.55469787
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50017520
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.47148619
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.44285615
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40590934
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37093686
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29858835
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28158517
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.26908713
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26258525
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25297404
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.24012921
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22750234
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17973690
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17429865
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.11891217
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10674217
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.04075908
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99548982
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99548982
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94633011
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90833667
35LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89325403
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.87272835
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86414813
38IGF1R_20145208_ChIP-Seq_DFB_Human1.80007792
39MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.77993037
40MYC_18940864_ChIP-ChIP_HL60_Human1.75189272
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.74490860
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.73028955
43RUNX1_26923725_Chip-Seq_HPCs_Mouse1.73001406
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.72266015
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63487999
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63449775
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63393565
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60083469
49EZH2_22144423_ChIP-Seq_EOC_Human1.59141759
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.58947003
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58201449
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57818710
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56770439
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.53558490
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53065553
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52198410
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51147003
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50405115
59RNF2_27304074_Chip-Seq_NSC_Mouse1.50320616
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49462868
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47547385
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36581643
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35109197
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33490365
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31978740
66SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30907077
67SMAD4_21799915_ChIP-Seq_A2780_Human1.29831594
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29287570
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27776361
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26817160
71STAT1_17558387_ChIP-Seq_HELA_Human1.25234254
72CDX2_22108803_ChIP-Seq_LS180_Human1.24204478
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23148204
74CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22367358
75NFYA_21822215_ChIP-Seq_K562_Human1.22021064
76TCF4_23295773_ChIP-Seq_U87_Human1.21747755
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20870264
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.20805925
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19657504
80GATA3_21867929_ChIP-Seq_TH1_Mouse1.18561501
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18385661
82ELK4_26923725_Chip-Seq_MESODERM_Mouse1.18239735
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17635526
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16924917
85AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14585191
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14347343
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14271300
88AR_19668381_ChIP-Seq_PC3_Human1.13879108
89OCT4_19829295_ChIP-Seq_ESCs_Human1.13441953
90AR_25329375_ChIP-Seq_VCAP_Human1.13338102
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.12118821
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12023964
93KLF4_19829295_ChIP-Seq_ESCs_Human1.11761447
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10558216
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09518731
96EWS_26573619_Chip-Seq_HEK293_Human1.09186158
97FUS_26573619_Chip-Seq_HEK293_Human1.08966210
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.08129529
99STAT3_23295773_ChIP-Seq_U87_Human1.06583833
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06569227
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06076649
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05926057
103TBL1_22424771_ChIP-Seq_293T_Human1.04415639
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.03384036
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02707868
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.02289021
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.02163945
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.01924957
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00907419
110KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00503205
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99166971
112SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.99049125
113BP1_19119308_ChIP-ChIP_Hs578T_Human0.98850785
114TET1_21490601_ChIP-Seq_MESCs_Mouse0.98181879
115HNFA_21074721_ChIP-Seq_CACO-2_Human0.97833748
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97180682
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96872428
118GF1B_26923725_Chip-Seq_HPCs_Mouse0.96111903
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96065300
120* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96025637
121ETV1_20927104_ChIP-Seq_GIST48_Human0.95918591
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.95910922
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95854893
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95042645
125CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94999798
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.93960589
127ERG_20517297_ChIP-Seq_VCAP_Human0.93739036
128AR_21572438_ChIP-Seq_LNCaP_Human0.93674698
129GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93509788
130GATA3_26560356_Chip-Seq_TH1_Human0.92938645
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92309297
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92309297
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91864295
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90713180
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90514891
136STAT3_18555785_Chip-Seq_ESCs_Mouse0.89663784
137FOXH1_21741376_ChIP-Seq_EPCs_Human0.89652884
138* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89606405
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.88721327
140MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88458707
141* SMAD4_21741376_ChIP-Seq_EPCs_Human0.88081519
142CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87141183
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86970981
144RBPJ_21746931_ChIP-Seq_IB4_Human0.86141993
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.85684516
146CTCF_18555785_Chip-Seq_ESCs_Mouse0.85602589
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85153234
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84605279
149CBX2_22325352_ChIP-Seq_293T-Rex_Human0.84570147
150* KAP1_27257070_Chip-Seq_ESCs_Mouse0.84459889
151CTCF_27219007_Chip-Seq_Bcells_Human0.84309957
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84309478
153CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84280127
154TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84068225
155RUNX2_22187159_ChIP-Seq_PCA_Human0.83831130
156TAF15_26573619_Chip-Seq_HEK293_Human0.83419451
157KLF4_18555785_Chip-Seq_ESCs_Mouse0.83169957
158FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82935194
159PHF8_20622853_ChIP-Seq_HELA_Human0.82345396
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81728881
161SMAD3_21741376_ChIP-Seq_ESCs_Human0.81703523
162EP300_21415370_ChIP-Seq_HL-1_Mouse0.81407462
163* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81295524
164ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81201517
165GATA6_21074721_ChIP-Seq_CACO-2_Human0.80890867
166CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80651225
167NMYC_18555785_Chip-Seq_ESCs_Mouse0.80611595
168SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79990313
169RING1B_27294783_Chip-Seq_NPCs_Mouse0.79554243
170EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78617493
171KDM2B_26808549_Chip-Seq_K562_Human0.77843286
172PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.77828507
173RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77050474
174CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76566603
175CBP_21632823_ChIP-Seq_H3396_Human0.75922366
176SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74679662
177UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.74012761
178THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73850514
179TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.72611852
180SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72534040
181CBX2_27304074_Chip-Seq_ESCs_Mouse0.72363518
182CBP_20019798_ChIP-Seq_JUKART_Human0.71333461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.17302066
2MP0003646_muscle_fatigue5.61657790
3MP0004859_abnormal_synaptic_plasticity5.34050292
4MP0005451_abnormal_body_composition4.75421833
5MP0003693_abnormal_embryo_hatching4.35094349
6MP0003880_abnormal_central_pattern4.13939841
7MP0002102_abnormal_ear_morphology3.87415600
8MP0004270_analgesia3.83942160
9MP0008877_abnormal_DNA_methylation3.81733079
10MP0003635_abnormal_synaptic_transmissio3.29574842
11MP0005395_other_phenotype3.14169811
12MP0010094_abnormal_chromosome_stability3.07280615
13MP0003111_abnormal_nucleus_morphology2.98807499
14MP0002064_seizures2.98620942
15MP0002653_abnormal_ependyma_morphology2.98058204
16MP0002272_abnormal_nervous_system2.97323271
17MP0003879_abnormal_hair_cell2.96105064
18MP0009745_abnormal_behavioral_response2.87962807
19MP0003077_abnormal_cell_cycle2.85441572
20MP0001119_abnormal_female_reproductive2.85280995
21* MP0003699_abnormal_female_reproductive2.82161388
22MP0004957_abnormal_blastocyst_morpholog2.72034998
23MP0005423_abnormal_somatic_nervous2.71848160
24MP0002063_abnormal_learning/memory/cond2.57467673
25MP0003787_abnormal_imprinting2.55746567
26MP0009046_muscle_twitch2.47768260
27MP0003121_genomic_imprinting2.44899960
28MP0006292_abnormal_olfactory_placode2.41406142
29MP0002734_abnormal_mechanical_nocicepti2.36642172
30* MP0001929_abnormal_gametogenesis2.33125470
31MP0002572_abnormal_emotion/affect_behav2.32609370
32MP0001486_abnormal_startle_reflex2.31835161
33MP0003123_paternal_imprinting2.30587292
34MP0000653_abnormal_sex_gland2.27871586
35MP0002210_abnormal_sex_determination2.18735795
36MP0002139_abnormal_hepatobiliary_system2.16265504
37MP0009780_abnormal_chondrocyte_physiolo2.08293060
38MP0001501_abnormal_sleep_pattern2.00105009
39MP0003122_maternal_imprinting1.99541819
40MP0001968_abnormal_touch/_nociception1.98496533
41MP0000579_abnormal_nail_morphology1.93743183
42MP0005646_abnormal_pituitary_gland1.88359326
43MP0005408_hypopigmentation1.87883666
44MP0002249_abnormal_larynx_morphology1.84653746
45MP0003315_abnormal_perineum_morphology1.79143516
46MP0003937_abnormal_limbs/digits/tail_de1.76257543
47MP0008932_abnormal_embryonic_tissue1.68508852
48MP0006276_abnormal_autonomic_nervous1.64711410
49MP0002735_abnormal_chemical_nociception1.61259074
50MP0001984_abnormal_olfaction1.59670387
51MP0002557_abnormal_social/conspecific_i1.57918709
52MP0005410_abnormal_fertilization1.53549030
53MP0001145_abnormal_male_reproductive1.53236451
54* MP0002161_abnormal_fertility/fecundity1.52524068
55MP0008569_lethality_at_weaning1.51053774
56MP0001502_abnormal_circadian_rhythm1.42864851
57MP0005499_abnormal_olfactory_system1.42766756
58MP0005394_taste/olfaction_phenotype1.42766756
59MP0001730_embryonic_growth_arrest1.41273618
60MP0001970_abnormal_pain_threshold1.40333690
61MP0001529_abnormal_vocalization1.38903578
62MP0004185_abnormal_adipocyte_glucose1.38482171
63MP0003633_abnormal_nervous_system1.37883393
64MP0002067_abnormal_sensory_capabilities1.37713746
65MP0005360_urolithiasis1.37520866
66MP0005257_abnormal_intraocular_pressure1.35571511
67MP0003183_abnormal_peptide_metabolism1.33385087
68MP0009379_abnormal_foot_pigmentation1.32995978
69MP0005551_abnormal_eye_electrophysiolog1.30527837
70MP0004811_abnormal_neuron_physiology1.29625838
71MP0001346_abnormal_lacrimal_gland1.29549516
72MP0001440_abnormal_grooming_behavior1.28141543
73MP0001905_abnormal_dopamine_level1.27600061
74MP0004885_abnormal_endolymph1.27154139
75MP0002733_abnormal_thermal_nociception1.25964790
76MP0000350_abnormal_cell_proliferation1.25963417
77MP0005310_abnormal_salivary_gland1.25118342
78MP0005645_abnormal_hypothalamus_physiol1.24186676
79* MP0002085_abnormal_embryonic_tissue1.22849473
80MP0002229_neurodegeneration1.22617473
81MP0002066_abnormal_motor_capabilities/c1.22582556
82MP0000462_abnormal_digestive_system1.16833676
83MP0008260_abnormal_autophagy1.16695506
84MP0001666_abnormal_nutrient_absorption1.15196786
85MP0002909_abnormal_adrenal_gland1.14756816
86MP0004264_abnormal_extraembryonic_tissu1.14554463
87MP0003631_nervous_system_phenotype1.14327926
88MP0001672_abnormal_embryogenesis/_devel1.14139290
89MP0005380_embryogenesis_phenotype1.14139290
90MP0002876_abnormal_thyroid_physiology1.14058302
91MP0003868_abnormal_feces_composition1.12997848
92MP0009840_abnormal_foam_cell1.11003422
93MP0002882_abnormal_neuron_morphology1.09507040
94MP0001697_abnormal_embryo_size1.09281025
95MP0004924_abnormal_behavior1.09278742
96MP0005386_behavior/neurological_phenoty1.09278742
97MP0002084_abnormal_developmental_patter1.05407908
98MP0008789_abnormal_olfactory_epithelium1.04589647
99MP0005187_abnormal_penis_morphology1.03962712
100MP0002736_abnormal_nociception_after1.03855072
101MP0010368_abnormal_lymphatic_system1.02927521
102MP0003283_abnormal_digestive_organ1.02675269
103MP0008007_abnormal_cellular_replicative1.02473398
104MP0001963_abnormal_hearing_physiology1.02219631
105MP0004742_abnormal_vestibular_system1.01783775
106MP0002160_abnormal_reproductive_system0.99820845
107MP0000639_abnormal_adrenal_gland0.99391815
108MP0003690_abnormal_glial_cell0.97763697
109MP0005409_darkened_coat_color0.97524265
110MP0000778_abnormal_nervous_system0.97049422
111MP0003195_calcinosis0.96716420
112MP0001986_abnormal_taste_sensitivity0.92495992
113MP0000955_abnormal_spinal_cord0.92134196
114MP0003890_abnormal_embryonic-extraembry0.91996343
115MP0008058_abnormal_DNA_repair0.90313678
116MP0001915_intracranial_hemorrhage0.90075935
117MP0005379_endocrine/exocrine_gland_phen0.88862218
118MP0001664_abnormal_digestion0.87960000
119MP0003698_abnormal_male_reproductive0.87639810
120MP0000920_abnormal_myelination0.87117544
121MP0010329_abnormal_lipoprotein_level0.86982000
122MP0002822_catalepsy0.86643157
123MP0002019_abnormal_tumor_incidence0.85702082
124MP0003950_abnormal_plasma_membrane0.85263137
125MP0002877_abnormal_melanocyte_morpholog0.84320272
126MP0002184_abnormal_innervation0.82707272
127MP0002089_abnormal_postnatal_growth/wei0.82325840
128MP0008057_abnormal_DNA_replication0.81860599
129MP0001919_abnormal_reproductive_system0.81771436
130MP0001849_ear_inflammation0.81730273
131MP0002234_abnormal_pharynx_morphology0.80994646
132MP0004142_abnormal_muscle_tone0.80992984
133MP0003755_abnormal_palate_morphology0.80831913
134MP0010386_abnormal_urinary_bladder0.79847822
135MP0001944_abnormal_pancreas_morphology0.78891709
136MP0002152_abnormal_brain_morphology0.78872705
137MP0000604_amyloidosis0.78551636
138MP0000613_abnormal_salivary_gland0.77411016
139MP0002069_abnormal_eating/drinking_beha0.77182689
140MP0005389_reproductive_system_phenotype0.76283340
141MP0002163_abnormal_gland_morphology0.74446229
142MP0000490_abnormal_crypts_of0.73036611
143MP0001765_abnormal_ion_homeostasis0.72740275
144MP0003632_abnormal_nervous_system0.72096578
145MP0003656_abnormal_erythrocyte_physiolo0.70680049
146MP0000566_synostosis0.70524811
147MP0001188_hyperpigmentation0.70484697
148MP0003984_embryonic_growth_retardation0.69507293
149MP0002932_abnormal_joint_morphology0.66948875
150MP0009250_abnormal_appendicular_skeleto0.66183031
151MP0002088_abnormal_embryonic_growth/wei0.65898530
152MP0004145_abnormal_muscle_electrophysio0.65699778
153MP0005621_abnormal_cell_physiology0.65552276
154MP0001851_eye_inflammation0.62819795
155MP0002080_prenatal_lethality0.61807240
156MP0002295_abnormal_pulmonary_circulatio0.61753175
157MP0010234_abnormal_vibrissa_follicle0.59934129
158MP0003453_abnormal_keratinocyte_physiol0.59346959
159MP0003861_abnormal_nervous_system0.57986343
160MP0002116_abnormal_craniofacial_bone0.57674930
161MP0000427_abnormal_hair_cycle0.56480120
162MP0009697_abnormal_copulation0.56142839
163MP0002282_abnormal_trachea_morphology0.54948650
164MP0002177_abnormal_outer_ear0.54783529
165MP0006072_abnormal_retinal_apoptosis0.54529926
166MP0003329_amyloid_beta_deposits0.52899400
167MP0005647_abnormal_sex_gland0.50992948
168MP0002086_abnormal_extraembryonic_tissu0.50987167
169MP0005384_cellular_phenotype0.50966127
170MP0000678_abnormal_parathyroid_gland0.50295923
171MP0000432_abnormal_head_morphology0.50201060
172MP0009384_cardiac_valve_regurgitation0.49366231
173MP0002109_abnormal_limb_morphology0.47633508
174MP0005197_abnormal_uvea_morphology0.47595046
175MP0000631_abnormal_neuroendocrine_gland0.47270392
176MP0008875_abnormal_xenobiotic_pharmacok0.46563287
177MP0003935_abnormal_craniofacial_develop0.45757178
178MP0000313_abnormal_cell_death0.45006989
179MP0004782_abnormal_surfactant_physiolog0.44270936
180MP0003938_abnormal_ear_development0.43445272

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.84803865
2Myokymia (HP:0002411)7.44492786
3Focal motor seizures (HP:0011153)5.44500297
4Febrile seizures (HP:0002373)5.18907511
5Atonic seizures (HP:0010819)5.10176769
6Birth length less than 3rd percentile (HP:0003561)5.09852487
7Cortical dysplasia (HP:0002539)4.88071303
8Premature ovarian failure (HP:0008209)4.87229355
9Breast hypoplasia (HP:0003187)4.85328061
10Papillary thyroid carcinoma (HP:0002895)4.75783362
11Focal seizures (HP:0007359)4.73703079
12Chromsome breakage (HP:0040012)4.56206744
13Supranuclear gaze palsy (HP:0000605)4.55039011
14Epileptic encephalopathy (HP:0200134)4.42947833
15Patellar aplasia (HP:0006443)4.35442219
16Flat capital femoral epiphysis (HP:0003370)4.19973366
17Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12628874
18Infertility (HP:0000789)4.10538620
19Facial hemangioma (HP:0000329)4.09994263
20Shawl scrotum (HP:0000049)4.03710511
21Aplasia/Hypoplasia of the patella (HP:0006498)4.01297182
22Adrenal hypoplasia (HP:0000835)3.93745156
23Action tremor (HP:0002345)3.93096017
24Abnormality of the labia minora (HP:0012880)3.84272938
25Secondary amenorrhea (HP:0000869)3.83056632
26Neurofibrillary tangles (HP:0002185)3.62724840
27Progressive cerebellar ataxia (HP:0002073)3.50298835
28Abnormality of aromatic amino acid family metabolism (HP:0004338)3.48722704
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.48612757
30Impulsivity (HP:0100710)3.40885609
31Apathy (HP:0000741)3.37927261
32Absence seizures (HP:0002121)3.34542737
33Torticollis (HP:0000473)3.34131137
34Aplasia/Hypoplasia of the breasts (HP:0010311)3.29670909
35Insulin-resistant diabetes mellitus (HP:0000831)3.29485377
36Breast aplasia (HP:0100783)3.25572076
37Generalized tonic-clonic seizures (HP:0002069)3.22829536
38Abnormal eating behavior (HP:0100738)3.21323159
39Capillary hemangiomas (HP:0005306)3.18760666
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.18140513
41Dialeptic seizures (HP:0011146)3.06821984
42Diminished motivation (HP:0000745)3.06537386
43Dysdiadochokinesis (HP:0002075)3.03118875
44Abnormality of binocular vision (HP:0011514)2.98542655
45Diplopia (HP:0000651)2.98542655
46Increased circulating renin level (HP:0000848)2.98066713
47Focal dystonia (HP:0004373)2.92383292
48Acute myeloid leukemia (HP:0004808)2.90627606
49Pulmonary fibrosis (HP:0002206)2.89375070
50Oligodactyly (hands) (HP:0001180)2.89113777
51Epileptiform EEG discharges (HP:0011182)2.85510107
52Abnormality of the fingertips (HP:0001211)2.85509895
53Atelectasis (HP:0100750)2.85096696
54Cholecystitis (HP:0001082)2.84112361
55Abnormal gallbladder physiology (HP:0012438)2.84112361
56Abnormality of the fovea (HP:0000493)2.83921775
57Hypergonadotropic hypogonadism (HP:0000815)2.82660313
58Status epilepticus (HP:0002133)2.81498737
59Limb dystonia (HP:0002451)2.77803043
60Arterial tortuosity (HP:0005116)2.76589538
61Abnormality of chromosome segregation (HP:0002916)2.72106579
62Abnormality of lateral ventricle (HP:0030047)2.71999195
63Bradykinesia (HP:0002067)2.71894015
64Malnutrition (HP:0004395)2.71238576
65Postural instability (HP:0002172)2.70608954
66Mutism (HP:0002300)2.68524078
67Hypokinesia (HP:0002375)2.64385309
68Gaze-evoked nystagmus (HP:0000640)2.61852540
69Hypoplasia of the fovea (HP:0007750)2.59519405
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.59519405
71Spastic gait (HP:0002064)2.58654321
72Visual hallucinations (HP:0002367)2.58576337
73Hyperglycemia (HP:0003074)2.57715612
74EEG with generalized epileptiform discharges (HP:0011198)2.55247744
75Osteomalacia (HP:0002749)2.54975631
76Amblyopia (HP:0000646)2.54503396
77Sandal gap (HP:0001852)2.54152373
78Craniofacial dystonia (HP:0012179)2.53769765
79Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.53015084
80Hypophosphatemic rickets (HP:0004912)2.52797834
81Chronic bronchitis (HP:0004469)2.52341385
82Ankle clonus (HP:0011448)2.50777484
83Oligodactyly (HP:0012165)2.50322698
84Anterior segment dysgenesis (HP:0007700)2.50222508
85Dysmetria (HP:0001310)2.50043301
86Impaired vibration sensation in the lower limbs (HP:0002166)2.49625686
87Hypoglycemic coma (HP:0001325)2.49516331
88Cerebral inclusion bodies (HP:0100314)2.47380760
89Deep venous thrombosis (HP:0002625)2.46883631
90Primary amenorrhea (HP:0000786)2.46691247
91Hypsarrhythmia (HP:0002521)2.43671659
92Cerebral hypomyelination (HP:0006808)2.42117321
93Abnormality of chromosome stability (HP:0003220)2.41889518
94Intention tremor (HP:0002080)2.39285278
95Carpal bone hypoplasia (HP:0001498)2.38476060
96Abnormality of the epiphysis of the femoral head (HP:0010574)2.36948814
97Depression (HP:0000716)2.36536008
98Thyroid carcinoma (HP:0002890)2.36455974
99Lip pit (HP:0100267)2.36350128
100Vascular tortuosity (HP:0004948)2.35492362
101Delusions (HP:0000746)2.34678364
102Urinary bladder sphincter dysfunction (HP:0002839)2.34318270
103Truncal ataxia (HP:0002078)2.31917919
104Supernumerary spleens (HP:0009799)2.31657995
105Abdominal situs inversus (HP:0003363)2.31370390
106Abnormality of abdominal situs (HP:0011620)2.31370390
107Spondylolisthesis (HP:0003302)2.31160250
108Anxiety (HP:0000739)2.30437718
109Obstructive sleep apnea (HP:0002870)2.29867045
110Overlapping toe (HP:0001845)2.27315110
111Abnormality of calcium-phosphate metabolism (HP:0100530)2.26707978
112Diminished movement (HP:0002374)2.26700088
113Aplasia/Hypoplasia of the uvula (HP:0010293)2.22965256
114Hyperphosphatemia (HP:0002905)2.22564255
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18274457
116Rigidity (HP:0002063)2.18100994
117Neuronal loss in central nervous system (HP:0002529)2.17976289
118Abnormality of the femoral head (HP:0003368)2.17791098
119Hypoplastic iliac wings (HP:0002866)2.17163197
120Tetraplegia (HP:0002445)2.17080776
121Abnormality of the preputium (HP:0100587)2.15615214
122Abnormality of small intestinal villus morphology (HP:0011472)2.14820214
123Villous atrophy (HP:0011473)2.14820214
124Rhabdomyosarcoma (HP:0002859)2.14540387
125Ventricular fibrillation (HP:0001663)2.13651574
126Wrist flexion contracture (HP:0001239)2.13585454
127Annular pancreas (HP:0001734)2.13340038
128Abnormality of the proximal phalanges of the hand (HP:0009834)2.13149379
129Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.13007355
130Abnormality of femoral epiphyses (HP:0006499)2.13007355
131Aplasia/Hypoplasia of the sternum (HP:0006714)2.11625940
132Nonprogressive disorder (HP:0003680)2.10313220
133Sloping forehead (HP:0000340)2.08507653
134Absent radius (HP:0003974)2.07519948
135Prostate neoplasm (HP:0100787)2.06103079
136Papilledema (HP:0001085)2.05851836
137Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05104003
138Meckel diverticulum (HP:0002245)2.02727732
139Bundle branch block (HP:0011710)2.02683518
140Hypoglycemic seizures (HP:0002173)2.02243720
141Impaired smooth pursuit (HP:0007772)2.02122088
142Absent forearm bone (HP:0003953)2.01260258
143Aplasia involving forearm bones (HP:0009822)2.01260258
144Abnormality of the corticospinal tract (HP:0002492)1.98188437
145Sparse lateral eyebrow (HP:0005338)1.96792088
146Abnormality of the phalanges of the hallux (HP:0010057)1.96751580
147Peripheral hypomyelination (HP:0007182)1.96191205
148Hemiparesis (HP:0001269)1.95968318
149Small intestinal stenosis (HP:0012848)1.95543427
150Duodenal stenosis (HP:0100867)1.95543427
151Fibular aplasia (HP:0002990)1.95102236
152Psychosis (HP:0000709)1.94311035
153Poor eye contact (HP:0000817)1.93566149
154Ectopic kidney (HP:0000086)1.93505889
155Akinesia (HP:0002304)1.92382577
156Spontaneous abortion (HP:0005268)1.90525710
157Hypercortisolism (HP:0001578)1.89610956
158Cystic hygroma (HP:0000476)1.89546803
159Abnormality of placental membranes (HP:0011409)1.86632900
160Amniotic constriction ring (HP:0009775)1.86632900
161Type 2 muscle fiber atrophy (HP:0003554)1.86318138
162Pancreatic fibrosis (HP:0100732)1.85896704
163Molar tooth sign on MRI (HP:0002419)1.85860072
164Abnormality of midbrain morphology (HP:0002418)1.85860072
165Choreoathetosis (HP:0001266)1.85739705
166Spinal canal stenosis (HP:0003416)1.85527756
167Urinary urgency (HP:0000012)1.85021530
168Fetal akinesia sequence (HP:0001989)1.84959317
169Hyperinsulinemic hypoglycemia (HP:0000825)1.84053422
170Abnormality of the ileum (HP:0001549)1.83790373
171Midline defect of the nose (HP:0004122)1.83005818
172Muscle fiber atrophy (HP:0100295)1.81201186
173Oral leukoplakia (HP:0002745)1.79867028
174Abnormality of the intervertebral disk (HP:0005108)1.79467435
175Abnormality of ocular smooth pursuit (HP:0000617)1.78447912
176Short thumb (HP:0009778)1.77798226
177Memory impairment (HP:0002354)1.77658265
178Clubbing of toes (HP:0100760)1.77197244
179Anosmia (HP:0000458)1.76726332
180Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76438876
181Hand muscle atrophy (HP:0009130)1.76119575
182Impaired vibratory sensation (HP:0002495)1.75960869
183Aplastic anemia (HP:0001915)1.75494655
184Prolonged partial thromboplastin time (HP:0003645)1.75386528
185Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74462720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.22064660
2MAP3K64.68800690
3NTRK34.22408389
4LATS13.69573920
5TAOK33.61058698
6LATS23.57580411
7ERBB43.40451983
8DAPK23.35910816
9PLK43.31981052
10KSR23.18468506
11MUSK3.07306268
12MAP3K93.01381671
13TTK2.87538859
14EEF2K2.80340065
15BRAF2.77197425
16MOS2.68909386
17STK38L2.59991216
18MAP3K132.41770984
19CDK82.32337187
20TAOK12.32280171
21CDC72.26819009
22MARK12.17928825
23ARAF2.17408545
24RAF12.08784892
25UHMK11.93806153
26PRKD31.86333958
27CHEK21.80601054
28BMPR21.78801887
29NEK61.72229149
30CAMKK11.66991015
31MELK1.65185038
32MAPKAPK31.62475077
33NEK21.60740577
34STK31.57360138
35CDK51.50272234
36GRK51.47367116
37PLK21.42800251
38MINK11.42780872
39DAPK11.39048851
40STK101.32224131
41CDK91.31510049
42PLK11.30461367
43CDK191.30180262
44PAK61.28133001
45MAPK131.24307890
46KSR11.23874752
47DYRK21.23417696
48CAMK11.22999406
49RIPK41.22681096
50BUB11.19080308
51PRKCG1.18906091
52MAPKAPK51.17685469
53DMPK1.09751914
54CASK1.06292275
55PRKD21.04505362
56MAP3K41.04285269
57TRIM281.00831570
58PHKG10.99203419
59PHKG20.99203419
60MAP3K80.95971031
61SIK20.94904995
62TNK20.92766542
63WNK10.92334897
64AURKB0.89296042
65TIE10.89195278
66PDK10.87317675
67NTRK10.87168862
68PAK30.85435445
69TYRO30.85123506
70AURKA0.84660025
71ACVR1B0.78481706
72ICK0.77888057
73PDPK10.77627372
74MAP2K70.77172796
75CSNK1G10.76880516
76ABL20.76522027
77WNK40.75037524
78PINK10.74603793
79PKN10.74367925
80TNIK0.74174211
81PRKCH0.74079148
82CDK11A0.73970960
83SGK10.72638143
84STK380.69511318
85PRKCZ0.68968302
86CDK180.67804010
87PRKCI0.66378896
88DYRK1A0.65662637
89CAMK40.64661477
90CAMK2B0.62792434
91RET0.61205930
92PRKAA20.60947982
93PRKAA10.60714972
94CDK70.60197650
95STK110.59792527
96MAP2K40.59334241
97NUAK10.59142350
98CDK140.58893274
99CDK120.58888704
100PLK30.58823987
101CAMK1G0.58267980
102NTRK20.56671650
103OXSR10.55967221
104PRKG10.55777174
105CHEK10.55607845
106CAMK1D0.55448907
107STK390.54999758
108TRPM70.54952699
109MARK20.54883093
110RPS6KA30.54745495
111NLK0.54601932
112FGFR20.53850391
113CDK30.53699672
114SGK30.53134356
115BRSK10.53015719
116CSNK1G20.52015457
117CSNK1G30.49928662
118CAMK2G0.49796383
119STK240.48957072
120MAP3K50.48557114
121RIPK10.47943266
122ATM0.46867157
123RPS6KB20.46749170
124MAPK110.46488145
125FGFR30.45236078
126MAP3K110.44983961
127MAP2K60.44106856
128PRKACA0.43205184
129BRSK20.39472048
130CAMK2D0.39259168
131GSK3B0.38452125
132PRPF4B0.38307877
133CDK40.38225935
134PRKCA0.36381138
135MAPK120.35759411
136DAPK30.35270272
137ALK0.34459243
138CDK10.34447931
139NEK10.32963009
140EIF2AK10.32928731
141MAP3K10.32826588
142CSNK1A1L0.32035042
143CDK20.30816900
144ABL10.28070521
145RPS6KA40.25116485
146SGK20.24577912
147VRK10.21814018
148MAP2K10.20561730
149CSNK1D0.20492800
150CAMK2A0.20292322
151PAK10.17464181
152CSNK1E0.16664783
153ATR0.16518335
154BMPR1B0.16332872
155SGK4940.14014722
156SGK2230.14014722
157WEE10.13894288
158SRPK10.13640764
159AKT10.13089127
160NEK90.12987612
161CDK150.12505934
162MAPK100.12220774
163MAPK140.10194713
164RPS6KA10.09946391

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.22738791
2Basal transcription factors_Homo sapiens_hsa030223.97423140
3Synaptic vesicle cycle_Homo sapiens_hsa047213.91153841
4Vitamin B6 metabolism_Homo sapiens_hsa007503.86846086
5Nicotine addiction_Homo sapiens_hsa050333.86352516
6Ovarian steroidogenesis_Homo sapiens_hsa049133.71256963
7RNA degradation_Homo sapiens_hsa030183.48212220
8Insulin secretion_Homo sapiens_hsa049112.92051045
9GABAergic synapse_Homo sapiens_hsa047272.67743193
10Circadian rhythm_Homo sapiens_hsa047102.66377153
11Long-term potentiation_Homo sapiens_hsa047202.56544081
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.47441064
13Morphine addiction_Homo sapiens_hsa050322.45033339
14Oocyte meiosis_Homo sapiens_hsa041142.44897590
15Amphetamine addiction_Homo sapiens_hsa050312.43721615
16Circadian entrainment_Homo sapiens_hsa047132.39417188
17RNA polymerase_Homo sapiens_hsa030202.35197725
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.30549546
19Homologous recombination_Homo sapiens_hsa034402.23835650
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23135591
21RNA transport_Homo sapiens_hsa030132.22593823
22Pancreatic cancer_Homo sapiens_hsa052122.22332353
23Fanconi anemia pathway_Homo sapiens_hsa034602.19848409
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16855207
25Linoleic acid metabolism_Homo sapiens_hsa005912.15818540
26Aldosterone synthesis and secretion_Homo sapiens_hsa049252.07160546
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.96429513
28Ether lipid metabolism_Homo sapiens_hsa005651.90896787
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90836852
30Dopaminergic synapse_Homo sapiens_hsa047281.90615784
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87809111
32p53 signaling pathway_Homo sapiens_hsa041151.79860213
33Dorso-ventral axis formation_Homo sapiens_hsa043201.78761201
34Gastric acid secretion_Homo sapiens_hsa049711.77884098
35Cocaine addiction_Homo sapiens_hsa050301.75963356
36TGF-beta signaling pathway_Homo sapiens_hsa043501.73489320
37Base excision repair_Homo sapiens_hsa034101.67737504
38GnRH signaling pathway_Homo sapiens_hsa049121.62100997
39Bile secretion_Homo sapiens_hsa049761.61876773
40Olfactory transduction_Homo sapiens_hsa047401.58584116
41Cholinergic synapse_Homo sapiens_hsa047251.56800699
42Non-homologous end-joining_Homo sapiens_hsa034501.52960075
43Salivary secretion_Homo sapiens_hsa049701.50132358
44Colorectal cancer_Homo sapiens_hsa052101.48080001
45Taste transduction_Homo sapiens_hsa047421.47185090
46MicroRNAs in cancer_Homo sapiens_hsa052061.43097671
47Calcium signaling pathway_Homo sapiens_hsa040201.40077863
48Prolactin signaling pathway_Homo sapiens_hsa049171.39356748
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38917745
50Mismatch repair_Homo sapiens_hsa034301.38426443
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37394443
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.35047406
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33149538
54Collecting duct acid secretion_Homo sapiens_hsa049661.31591625
55Choline metabolism in cancer_Homo sapiens_hsa052311.29617906
56DNA replication_Homo sapiens_hsa030301.28947503
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27916616
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27208213
59Renin secretion_Homo sapiens_hsa049241.25375317
60Nucleotide excision repair_Homo sapiens_hsa034201.22384833
61SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21548061
62Fatty acid biosynthesis_Homo sapiens_hsa000611.20806784
63Renal cell carcinoma_Homo sapiens_hsa052111.19369158
64mTOR signaling pathway_Homo sapiens_hsa041501.14423712
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13935232
66Phototransduction_Homo sapiens_hsa047441.09767121
67Glycerophospholipid metabolism_Homo sapiens_hsa005641.08845293
68Thyroid hormone synthesis_Homo sapiens_hsa049181.07692646
69mRNA surveillance pathway_Homo sapiens_hsa030151.05769429
70VEGF signaling pathway_Homo sapiens_hsa043701.04698765
71Butanoate metabolism_Homo sapiens_hsa006501.04119927
72Arginine biosynthesis_Homo sapiens_hsa002200.99399832
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95852717
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95094773
75Pancreatic secretion_Homo sapiens_hsa049720.91736379
76Hippo signaling pathway_Homo sapiens_hsa043900.89383125
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89116625
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86603524
79FoxO signaling pathway_Homo sapiens_hsa040680.85112198
80Other glycan degradation_Homo sapiens_hsa005110.83315914
81Pyrimidine metabolism_Homo sapiens_hsa002400.82618631
82ABC transporters_Homo sapiens_hsa020100.80789157
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80079163
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79353693
85Non-small cell lung cancer_Homo sapiens_hsa052230.79057822
86Long-term depression_Homo sapiens_hsa047300.78790844
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78202236
88Purine metabolism_Homo sapiens_hsa002300.77799430
89Endometrial cancer_Homo sapiens_hsa052130.76540832
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75791114
91Type II diabetes mellitus_Homo sapiens_hsa049300.74184887
92Bladder cancer_Homo sapiens_hsa052190.72346984
93Thyroid cancer_Homo sapiens_hsa052160.72283069
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72175627
95Melanogenesis_Homo sapiens_hsa049160.69558693
96Adherens junction_Homo sapiens_hsa045200.68431046
97Ras signaling pathway_Homo sapiens_hsa040140.68177355
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68171931
99Cardiac muscle contraction_Homo sapiens_hsa042600.68015550
100Chronic myeloid leukemia_Homo sapiens_hsa052200.67028183
101Small cell lung cancer_Homo sapiens_hsa052220.66939756
102Inositol phosphate metabolism_Homo sapiens_hsa005620.66163694
103Vibrio cholerae infection_Homo sapiens_hsa051100.65391833
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.64082062
105Glucagon signaling pathway_Homo sapiens_hsa049220.63198524
106Notch signaling pathway_Homo sapiens_hsa043300.59151989
107Histidine metabolism_Homo sapiens_hsa003400.58042789
108Hepatitis B_Homo sapiens_hsa051610.57940663
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57162205
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56806640
111HTLV-I infection_Homo sapiens_hsa051660.54754718
112Estrogen signaling pathway_Homo sapiens_hsa049150.52218530
113Prostate cancer_Homo sapiens_hsa052150.52077046
114Arachidonic acid metabolism_Homo sapiens_hsa005900.50494323
115Folate biosynthesis_Homo sapiens_hsa007900.49358473
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47483628
117Glioma_Homo sapiens_hsa052140.46378286
118Regulation of autophagy_Homo sapiens_hsa041400.44876885
119Complement and coagulation cascades_Homo sapiens_hsa046100.44737219
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44047795
121Melanoma_Homo sapiens_hsa052180.43486457
122ErbB signaling pathway_Homo sapiens_hsa040120.42505117
123MAPK signaling pathway_Homo sapiens_hsa040100.40345717
124Mineral absorption_Homo sapiens_hsa049780.39906372
125Fatty acid metabolism_Homo sapiens_hsa012120.38846069
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37460820
127Herpes simplex infection_Homo sapiens_hsa051680.35927191
128Sphingolipid metabolism_Homo sapiens_hsa006000.35173965
129Shigellosis_Homo sapiens_hsa051310.34225642
130Epstein-Barr virus infection_Homo sapiens_hsa051690.33744187
131Rap1 signaling pathway_Homo sapiens_hsa040150.33416073
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33399990
133Phenylalanine metabolism_Homo sapiens_hsa003600.32862346
134Serotonergic synapse_Homo sapiens_hsa047260.32742733
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.29805138
136Wnt signaling pathway_Homo sapiens_hsa043100.28722211
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28377595
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.28310971
139Insulin signaling pathway_Homo sapiens_hsa049100.28080336
140Fat digestion and absorption_Homo sapiens_hsa049750.27559052
141PPAR signaling pathway_Homo sapiens_hsa033200.26837874
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26296396
143Axon guidance_Homo sapiens_hsa043600.26152785
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25204506
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24199704
146Alcoholism_Homo sapiens_hsa050340.23998465
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.22941001
148Gap junction_Homo sapiens_hsa045400.22824591
149Sulfur metabolism_Homo sapiens_hsa009200.22205287
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.22158115
151Pathways in cancer_Homo sapiens_hsa052000.22073457
152Glutamatergic synapse_Homo sapiens_hsa047240.21068440
153cAMP signaling pathway_Homo sapiens_hsa040240.20040870
154Viral carcinogenesis_Homo sapiens_hsa052030.19652289
155Arginine and proline metabolism_Homo sapiens_hsa003300.18179285
156Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17166089
157Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16527403
158Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16480609
159Oxytocin signaling pathway_Homo sapiens_hsa049210.16354363
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16234181
161Steroid biosynthesis_Homo sapiens_hsa001000.15986752
162Hedgehog signaling pathway_Homo sapiens_hsa043400.15440955
163TNF signaling pathway_Homo sapiens_hsa046680.14209520

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