NPPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.83195043
2sarcomere organization (GO:0045214)9.75239964
3myofibril assembly (GO:0030239)8.31444802
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.22403881
5negative regulation of potassium ion transmembrane transport (GO:1901380)7.45283136
6actin-myosin filament sliding (GO:0033275)7.44273074
7muscle filament sliding (GO:0030049)7.44273074
8cardiac muscle contraction (GO:0060048)7.34850892
9cardiac muscle cell development (GO:0055013)7.19390710
10regulation of sarcomere organization (GO:0060297)6.94125057
11cardiac muscle tissue morphogenesis (GO:0055008)6.86297421
12adult heart development (GO:0007512)6.81649186
13ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.80287629
14cardiac cell development (GO:0055006)6.76314176
15tricarboxylic acid cycle (GO:0006099)6.52904663
16cardiac ventricle formation (GO:0003211)6.46190674
17regulation of relaxation of muscle (GO:1901077)6.45858402
18regulation of actin filament-based movement (GO:1903115)6.35381890
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.31455837
20actomyosin structure organization (GO:0031032)6.29320234
21* cardiac muscle hypertrophy (GO:0003300)6.19938418
22actin-mediated cell contraction (GO:0070252)6.16161526
23bundle of His cell to Purkinje myocyte communication (GO:0086069)6.14309458
24heart trabecula formation (GO:0060347)6.11317201
25muscle tissue morphogenesis (GO:0060415)6.09990104
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.86843457
27* striated muscle hypertrophy (GO:0014897)5.83614994
28ventricular cardiac muscle cell action potential (GO:0086005)5.80824636
29heart process (GO:0003015)5.72716256
30heart contraction (GO:0060047)5.72716256
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.66870254
32atrial septum morphogenesis (GO:0060413)5.64505409
33regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.55408771
34plasma membrane repair (GO:0001778)5.49046480
35regulation of the force of heart contraction (GO:0002026)5.41048572
36striated muscle contraction (GO:0006941)5.40155730
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.38342173
38regulation of striated muscle contraction (GO:0006942)5.17367022
39* muscle hypertrophy (GO:0014896)5.15552282
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.14697222
41atrioventricular valve morphogenesis (GO:0003181)5.07774651
42ventricular cardiac muscle cell development (GO:0055015)5.07099005
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.03810131
44regulation of skeletal muscle contraction (GO:0014819)4.92071921
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.90112799
46positive regulation of cardiac muscle cell proliferation (GO:0060045)4.89645312
47regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.86604946
48cell communication involved in cardiac conduction (GO:0086065)4.83013916
49positive regulation of cardiac muscle tissue growth (GO:0055023)4.74934462
50negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.70542559
51carnitine shuttle (GO:0006853)4.69624098
52actin filament-based movement (GO:0030048)4.64628430
53energy coupled proton transport, down electrochemical gradient (GO:0015985)4.64107861
54ATP synthesis coupled proton transport (GO:0015986)4.64107861
55regulation of membrane repolarization (GO:0060306)4.59638847
56cell migration involved in heart development (GO:0060973)4.49241965
57cell communication by electrical coupling (GO:0010644)4.45744527
58regulation of cardioblast proliferation (GO:0003264)4.44073961
59regulation of secondary heart field cardioblast proliferation (GO:0003266)4.44073961
60regulation of acyl-CoA biosynthetic process (GO:0050812)4.42888803
61relaxation of smooth muscle (GO:0044557)4.41749937
62regulation of cardioblast differentiation (GO:0051890)4.39025969
63regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.38181321
64regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.37014042
65regulation of cardiac muscle contraction (GO:0055117)4.28917701
66positive regulation of cardiac muscle tissue development (GO:0055025)4.28312182
67regulation of cell communication by electrical coupling (GO:0010649)4.24895892
68positive regulation of heart growth (GO:0060421)4.23870270
69negative regulation of protein localization to cell surface (GO:2000009)4.23230051
70regulation of ATP catabolic process (GO:1903289)4.20593772
71regulation of ATPase activity (GO:0043462)4.20593772
72sarcoplasmic reticulum calcium ion transport (GO:0070296)4.20224566
73* muscle hypertrophy in response to stress (GO:0003299)4.19901280
74* cardiac muscle adaptation (GO:0014887)4.19901280
75* cardiac muscle hypertrophy in response to stress (GO:0014898)4.19901280
76adrenergic receptor signaling pathway (GO:0071875)4.19784429
77relaxation of muscle (GO:0090075)4.18581786
78negative regulation of striated muscle cell apoptotic process (GO:0010664)4.16626219
79response to inactivity (GO:0014854)4.14437366
80negative regulation of cardiac muscle hypertrophy (GO:0010614)4.13302987
81oxidative phosphorylation (GO:0006119)4.13021814
82cardiac muscle cell action potential involved in contraction (GO:0086002)4.12927667
83regulation of heart rate (GO:0002027)4.12633180
84regulation of cardiac muscle cell contraction (GO:0086004)4.11556692
85regulation of cofactor metabolic process (GO:0051193)4.10538897
86regulation of coenzyme metabolic process (GO:0051196)4.10538897
87fatty acid transmembrane transport (GO:1902001)4.09903379
88respiratory electron transport chain (GO:0022904)4.08511842
89endocardial cushion development (GO:0003197)4.06695991
90cardiac muscle cell action potential (GO:0086001)4.06485534
91negative regulation of potassium ion transport (GO:0043267)4.05620455
92regulation of cardiac muscle cell proliferation (GO:0060043)4.00412609
93electron transport chain (GO:0022900)3.98542588
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.97636113
95trabecula formation (GO:0060343)3.94955613
96regulation of heart contraction (GO:0008016)3.89909087
97striated muscle cell development (GO:0055002)3.83836373
98response to caffeine (GO:0031000)3.82060426
99relaxation of cardiac muscle (GO:0055119)3.81686945
100embryonic heart tube development (GO:0035050)3.79547390
101regulation of heart growth (GO:0060420)3.74772610
102NADH metabolic process (GO:0006734)3.68596729
103response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.68330315
104potassium ion export (GO:0071435)3.68227558
105negative regulation of muscle hypertrophy (GO:0014741)3.68220728
106cardiac conduction (GO:0061337)3.64971967
107regulation of cardiac muscle tissue growth (GO:0055021)3.60697277
108positive regulation of ATPase activity (GO:0032781)3.60652030
109positive regulation of ATP catabolic process (GO:1903291)3.60652030
110striated muscle cell proliferation (GO:0014855)3.58670805
111regulation of heart rate by cardiac conduction (GO:0086091)3.56170278
112negative regulation of myotube differentiation (GO:0010832)3.55176488
113regulation of cardiac muscle cell apoptotic process (GO:0010665)3.52208419
114regulation of cardiac muscle tissue development (GO:0055024)3.52038909
1152-oxoglutarate metabolic process (GO:0006103)3.50297386
116regulation of muscle contraction (GO:0006937)3.45854001
117outflow tract septum morphogenesis (GO:0003148)3.44421391
118carnitine transmembrane transport (GO:1902603)3.42842110
119positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.42231140
120regulation of striated muscle cell apoptotic process (GO:0010662)3.40809573
121cardiac muscle cell proliferation (GO:0060038)3.34364793
122cardiac chamber formation (GO:0003207)3.32377207
123regulation of sulfur metabolic process (GO:0042762)3.31482755
124negative regulation of cytosolic calcium ion concentration (GO:0051481)3.30995260
125muscle cell development (GO:0055001)3.28921362
126oxygen transport (GO:0015671)3.28674426
127muscle contraction (GO:0006936)3.22389259
128cardiac muscle tissue development (GO:0048738)3.20067641
129desmosome organization (GO:0002934)3.17399431
130regulation of muscle system process (GO:0090257)3.12913800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.13971713
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.92248895
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.85562419
4TBX20_22328084_ChIP-Seq_HEART_Mouse4.41165532
5TBX20_22080862_ChIP-Seq_HEART_Mouse4.41165532
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.98301158
7MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.72690281
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.72561382
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.44947995
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.04110206
11ZNF263_19887448_ChIP-Seq_K562_Human2.88001920
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.87747388
13GATA4_21415370_ChIP-Seq_HL-1_Mouse2.79136032
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.65755072
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.62749129
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60692413
17VDR_22108803_ChIP-Seq_LS180_Human2.36180108
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.21550861
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.13317916
20CLOCK_20551151_ChIP-Seq_293T_Human2.08441570
21NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.02529523
22PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.97038428
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.95991604
24EZH2_22144423_ChIP-Seq_EOC_Human1.93657732
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93477031
26GATA1_22025678_ChIP-Seq_K562_Human1.90899844
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.87822554
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.80071743
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78335368
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76535161
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70542922
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69742894
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67517565
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62992435
35SMAD4_21799915_ChIP-Seq_A2780_Human1.62983212
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62555677
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59476990
38GBX2_23144817_ChIP-Seq_PC3_Human1.57670705
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.52756235
40TAF15_26573619_Chip-Seq_HEK293_Human1.51258364
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41569934
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.41226226
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.39050774
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37432456
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37166085
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33961986
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32076590
48CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31851516
49TP53_16413492_ChIP-PET_HCT116_Human1.31669947
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30524524
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28054259
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27519566
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26687015
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26468477
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23091540
56HTT_18923047_ChIP-ChIP_STHdh_Human1.22484778
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.21129034
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20687799
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19301589
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19172579
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18520345
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.17459583
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.17251398
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.17106488
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.16957407
66CTCF_27219007_Chip-Seq_Bcells_Human1.16769352
67* GATA1_19941826_ChIP-Seq_K562_Human1.16575352
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.15932140
69* TBL1_22424771_ChIP-Seq_293T_Human1.14779447
70* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14236935
71SPI1_20517297_ChIP-Seq_HL60_Human1.13620955
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12812902
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12812902
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10975977
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09519535
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08605073
77TP63_22573176_ChIP-Seq_HFKS_Human1.07786782
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07674436
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06278029
80BCAT_22108803_ChIP-Seq_LS180_Human1.06102461
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06013827
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04339566
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04072203
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.03193670
85TCF4_23295773_ChIP-Seq_U87_Human1.02913784
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.02902158
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02703443
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02420339
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.02271053
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.02127861
91LXR_22292898_ChIP-Seq_THP-1_Human1.01469239
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01385400
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.00029359
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99845723
95* KDM2B_26808549_Chip-Seq_DND41_Human0.99579287
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98411770
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97871313
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97786727
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.97717337
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97131596
101ATF3_27146783_Chip-Seq_COLON_Human0.96636845
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96195419
103DROSHA_22980978_ChIP-Seq_HELA_Human0.96172085
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96138341
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96099150
106TCF4_18268006_ChIP-ChIP_LS174T_Human0.96067103
107RACK7_27058665_Chip-Seq_MCF-7_Human0.95992955
108MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95728734
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95290630
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95035305
111SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94981310
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93077944
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93077944
114SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92400006
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90632569
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90401477
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.90199468
118EOMES_21245162_ChIP-Seq_HESCs_Human0.90117944
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89848756
120SOX2_18555785_Chip-Seq_ESCs_Mouse0.88730321
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88666362
122* NFYA_21822215_ChIP-Seq_K562_Human0.88244817
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87855388
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87482026
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.87217226
126CRX_20693478_ChIP-Seq_RETINA_Mouse0.86853273
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86767864
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86328003
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86132491
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85922381
131RXR_22158963_ChIP-Seq_LIVER_Mouse0.85738109
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85501875
133SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84293169
134* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.83600243
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83575673
136ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82998169
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.82382880
138* GATA2_19941826_ChIP-Seq_K562_Human0.80203629
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79624742
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.79366750
141CJUN_26792858_Chip-Seq_BT549_Human0.79332276
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78612688
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.77652208
144ZNF274_21170338_ChIP-Seq_K562_Hela0.77483506
145P68_20966046_ChIP-Seq_HELA_Human0.76233190
146GATA1_19941827_ChIP-Seq_MEL_Mouse0.76020995
147EGR1_19032775_ChIP-ChIP_M12_Human0.75911486
148SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.75725545
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75054654
150GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75034762
151TP53_23651856_ChIP-Seq_MEFs_Mouse0.74595354
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.74529336
153OCT4_20526341_ChIP-Seq_ESCs_Human0.73673331
154FOXH1_21741376_ChIP-Seq_ESCs_Human0.72782620
155LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.71098704
156SMAD4_21741376_ChIP-Seq_HESCs_Human0.71040687
157SPI1_23127762_ChIP-Seq_K562_Human0.70346155
158BCOR_27268052_Chip-Seq_Bcells_Human0.69958931
159BCL6_27268052_Chip-Seq_Bcells_Human0.69955555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.15288425
2MP0004084_abnormal_cardiac_muscle6.74130559
3MP0004215_abnormal_myocardial_fiber4.96634221
4MP0000751_myopathy4.79111993
5MP0004036_abnormal_muscle_relaxation4.59253667
6MP0003646_muscle_fatigue4.55906763
7MP0005330_cardiomyopathy4.33982874
8MP0000749_muscle_degeneration3.88218333
9MP0002972_abnormal_cardiac_muscle3.49320725
10MP0004087_abnormal_muscle_fiber3.09482287
11MP0003137_abnormal_impulse_conducting3.01775181
12* MP0008775_abnormal_heart_ventricle3.00446041
13MP0010630_abnormal_cardiac_muscle2.91478463
14* MP0005385_cardiovascular_system_phenoty2.78637211
15* MP0001544_abnormal_cardiovascular_syste2.78637211
16MP0006138_congestive_heart_failure2.70274647
17MP0005620_abnormal_muscle_contractility2.69787515
18MP0003828_pulmonary_edema2.52921055
19MP0000750_abnormal_muscle_regeneration2.50282175
20* MP0004085_abnormal_heartbeat2.30221702
21MP0002106_abnormal_muscle_physiology2.25844274
22MP0004484_altered_response_of2.23413883
23MP0003221_abnormal_cardiomyocyte_apopto2.21517949
24MP0002269_muscular_atrophy2.16758847
25MP0004510_myositis2.14994826
26MP0004130_abnormal_muscle_cell2.08572138
27MP0002127_abnormal_cardiovascular_syste1.99324052
28MP0003950_abnormal_plasma_membrane1.87133343
29MP0005369_muscle_phenotype1.80293039
30MP0000759_abnormal_skeletal_muscle1.66479639
31MP0004145_abnormal_muscle_electrophysio1.64661521
32MP0000747_muscle_weakness1.64030752
33MP0006036_abnormal_mitochondrial_physio1.62098955
34MP0004233_abnormal_muscle_weight1.51191308
35MP0003567_abnormal_fetal_cardiomyocyte1.45185026
36MP0003279_aneurysm1.32655816
37MP0008004_abnormal_stomach_pH1.32069123
38MP0010368_abnormal_lymphatic_system1.25583074
39* MP0000266_abnormal_heart_morphology1.24517258
40MP0000343_altered_response_to1.15778908
41MP0002332_abnormal_exercise_endurance1.14213334
42MP0002102_abnormal_ear_morphology1.06918524
43MP0005666_abnormal_adipose_tissue1.06516431
44MP0003566_abnormal_cell_adhesion1.00577488
45MP0005165_increased_susceptibility_to1.00031566
46MP0002234_abnormal_pharynx_morphology0.97047750
47MP0006035_abnormal_mitochondrial_morpho0.94697059
48MP0004272_abnormal_basement_membrane0.94372902
49MP0005451_abnormal_body_composition0.91869414
50MP0005623_abnormal_meninges_morphology0.89779609
51* MP0002128_abnormal_blood_circulation0.86973372
52MP0005670_abnormal_white_adipose0.85518654
53MP0008438_abnormal_cutaneous_collagen0.80913356
54MP0003806_abnormal_nucleotide_metabolis0.80213519
55MP0001661_extended_life_span0.78699362
56MP0003705_abnormal_hypodermis_morpholog0.75233630
57* MP0000230_abnormal_systemic_arterial0.73460124
58MP0005266_abnormal_metabolism0.71768549
59MP0001879_abnormal_lymphatic_vessel0.70299191
60MP0005375_adipose_tissue_phenotype0.69038745
61MP0004185_abnormal_adipocyte_glucose0.68829827
62MP0002108_abnormal_muscle_morphology0.64507687
63* MP0000767_abnormal_smooth_muscle0.60698562
64MP0002925_abnormal_cardiovascular_devel0.58996603
65MP0002909_abnormal_adrenal_gland0.58849409
66MP0003984_embryonic_growth_retardation0.54439991
67MP0002088_abnormal_embryonic_growth/wei0.53689229
68MP0005275_abnormal_skin_tensile0.53466984
69MP0001958_emphysema0.46750498
70MP0000462_abnormal_digestive_system0.45682080
71MP0000013_abnormal_adipose_tissue0.45552725
72MP0001784_abnormal_fluid_regulation0.43874127
73* MP0001614_abnormal_blood_vessel0.43454561
74MP0001299_abnormal_eye_distance/0.43042953
75MP0005187_abnormal_penis_morphology0.42491215
76MP0008874_decreased_physiological_sensi0.42332419
77MP0003136_yellow_coat_color0.41949867
78MP0005319_abnormal_enzyme/_coenzyme0.41732165
79MP0009384_cardiac_valve_regurgitation0.41640808
80MP0000003_abnormal_adipose_tissue0.41516930
81MP0000733_abnormal_muscle_development0.40459506
82MP0000516_abnormal_urinary_system0.35360905
83MP0005367_renal/urinary_system_phenotyp0.35360905
84MP0005248_abnormal_Harderian_gland0.35051394
85MP0005595_abnormal_vascular_smooth0.34733124
86MP0001730_embryonic_growth_arrest0.34393837
87MP0003941_abnormal_skin_development0.33851914
88MP0004043_abnormal_pH_regulation0.33648935
89MP0003122_maternal_imprinting0.33448957
90MP0000427_abnormal_hair_cycle0.32912804
91MP0005503_abnormal_tendon_morphology0.32900400
92MP0002078_abnormal_glucose_homeostasis0.32603467
93MP0005380_embryogenesis_phenotype0.31134610
94MP0001672_abnormal_embryogenesis/_devel0.31134610
95MP0005508_abnormal_skeleton_morphology0.30879940
96MP0005388_respiratory_system_phenotype0.30481929
97MP0002133_abnormal_respiratory_system0.30481929
98MP0003935_abnormal_craniofacial_develop0.29765976
99MP0001727_abnormal_embryo_implantation0.29206037
100MP0003948_abnormal_gas_homeostasis0.28704288
101MP0004147_increased_porphyrin_level0.28166413
102MP0002971_abnormal_brown_adipose0.26500392
103MP0008961_abnormal_basal_metabolism0.26166050
104MP0005167_abnormal_blood-brain_barrier0.26061167
105MP0000249_abnormal_blood_vessel0.25668182
106MP0002295_abnormal_pulmonary_circulatio0.24968672
107MP0006054_spinal_hemorrhage0.23703711
108MP0003045_fibrosis0.23452518
109MP0001529_abnormal_vocalization0.21269051
110MP0003091_abnormal_cell_migration0.20777725
111MP0005535_abnormal_body_temperature0.20344198
112MP0005332_abnormal_amino_acid0.20165698
113MP0003878_abnormal_ear_physiology0.20112650
114MP0005377_hearing/vestibular/ear_phenot0.20112650
115MP0001984_abnormal_olfaction0.19784638
116MP0005253_abnormal_eye_physiology0.18085801
117MP0003937_abnormal_limbs/digits/tail_de0.18045954
118MP0002249_abnormal_larynx_morphology0.17637489
119* MP0005584_abnormal_enzyme/coenzyme_acti0.17460217
120MP0005386_behavior/neurological_phenoty0.17238728
121MP0004924_abnormal_behavior0.17238728
122MP0002090_abnormal_vision0.16833949
123MP0001175_abnormal_lung_morphology0.16350413
124MP0003123_paternal_imprinting0.16200853
125MP0009250_abnormal_appendicular_skeleto0.15112930
126MP0009780_abnormal_chondrocyte_physiolo0.14272725
127MP0000371_diluted_coat_color0.13524100

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.88578326
2Ventricular tachycardia (HP:0004756)7.24232858
3Calf muscle hypertrophy (HP:0008981)6.32167033
4* Atrial fibrillation (HP:0005110)6.31813592
5Lipoatrophy (HP:0100578)5.96855352
6* Primary atrial arrhythmia (HP:0001692)5.89049847
7Subaortic stenosis (HP:0001682)5.80511960
8Abnormality of the left ventricular outflow tract (HP:0011103)5.80511960
9* Supraventricular tachycardia (HP:0004755)5.69759704
10Abnormality of the calf musculature (HP:0001430)5.61427591
11Muscle hypertrophy of the lower extremities (HP:0008968)5.61065674
12* Supraventricular arrhythmia (HP:0005115)5.60086034
13Right ventricular cardiomyopathy (HP:0011663)5.55720067
14Exercise-induced muscle cramps (HP:0003710)5.52010196
15Exercise-induced myalgia (HP:0003738)5.09253497
16Muscle fiber splitting (HP:0003555)5.07060392
17Syncope (HP:0001279)5.04093727
18Hyporeflexia of lower limbs (HP:0002600)4.88684764
19Dilated cardiomyopathy (HP:0001644)4.85720057
20Palpitations (HP:0001962)4.85576682
21Ventricular arrhythmia (HP:0004308)4.55165926
22Asymmetric septal hypertrophy (HP:0001670)4.49894862
23Prolonged QT interval (HP:0001657)4.48539336
24Bundle branch block (HP:0011710)4.44889366
25Myoglobinuria (HP:0002913)4.32709357
26EMG: myopathic abnormalities (HP:0003458)4.13381447
27Ventricular fibrillation (HP:0001663)3.87591278
28Heart block (HP:0012722)3.79782120
29Atrioventricular block (HP:0001678)3.76769089
30Hypoplastic heart (HP:0001961)3.72023158
31Increased connective tissue (HP:0009025)3.59640470
32Abnormal atrioventricular conduction (HP:0005150)3.58359012
33Rhabdomyolysis (HP:0003201)3.30887908
34Abnormal EKG (HP:0003115)3.24600464
35Ragged-red muscle fibers (HP:0003200)3.21082299
36Aplasia of the musculature (HP:0100854)3.13260583
37Anomalous pulmonary venous return (HP:0010772)3.11129370
38Left ventricular hypertrophy (HP:0001712)3.07241975
39Abnormal mitochondria in muscle tissue (HP:0008316)3.06165639
40Acute necrotizing encephalopathy (HP:0006965)3.03872542
41Toxemia of pregnancy (HP:0100603)3.03139784
42Myotonia (HP:0002486)2.98585574
43Hepatic necrosis (HP:0002605)2.98423455
44Partial duplication of thumb phalanx (HP:0009944)2.97854139
45Palmoplantar keratoderma (HP:0000982)2.97525660
46Hypoglycemic coma (HP:0001325)2.76122661
47Conjunctival hamartoma (HP:0100780)2.73645162
48Distal lower limb muscle weakness (HP:0009053)2.73565748
49Abnormality of the pulmonary veins (HP:0011718)2.69016817
50Difficulty running (HP:0009046)2.67595939
51* Bradycardia (HP:0001662)2.66054725
52Ketoacidosis (HP:0001993)2.62144477
53Acute encephalopathy (HP:0006846)2.58560438
54Partial duplication of the phalanx of hand (HP:0009999)2.56953101
55Pheochromocytoma (HP:0002666)2.56709128
56Neck muscle weakness (HP:0000467)2.53527658
57Hepatocellular necrosis (HP:0001404)2.50862097
58Abnormality of the foot musculature (HP:0001436)2.50708723
59Neoplasm of the adrenal gland (HP:0100631)2.50045176
60Progressive macrocephaly (HP:0004481)2.48956083
61Difficulty climbing stairs (HP:0003551)2.45933020
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.45314308
63Steppage gait (HP:0003376)2.43274260
64Mitochondrial inheritance (HP:0001427)2.42881721
65Cerebral edema (HP:0002181)2.36763586
66Sudden cardiac death (HP:0001645)2.35776519
67Type 1 muscle fiber predominance (HP:0003803)2.35208013
68Increased CSF lactate (HP:0002490)2.34533124
69Abnormality of fatty-acid metabolism (HP:0004359)2.32190951
70Limb-girdle muscle atrophy (HP:0003797)2.29472473
71Neuroendocrine neoplasm (HP:0100634)2.28263931
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27740488
73Dicarboxylic aciduria (HP:0003215)2.27740488
74Congestive heart failure (HP:0001635)2.25488282
75Mildly elevated creatine phosphokinase (HP:0008180)2.21080755
76Areflexia of lower limbs (HP:0002522)2.19536975
77Increased muscle lipid content (HP:0009058)2.17290382
78Foot dorsiflexor weakness (HP:0009027)2.15843450
79Exercise intolerance (HP:0003546)2.12345684
80Increased variability in muscle fiber diameter (HP:0003557)2.12040760
81EMG: neuropathic changes (HP:0003445)2.11338189
82Hamartoma of the eye (HP:0010568)2.08809668
83Complete atrioventricular canal defect (HP:0001674)2.07410078
84Increased serum pyruvate (HP:0003542)2.05660104
85Abnormality of glycolysis (HP:0004366)2.05660104
86Pulmonary artery stenosis (HP:0004415)2.05266595
87Transposition of the great arteries (HP:0001669)2.02618829
88Abnormal connection of the cardiac segments (HP:0011545)2.02618829
89Abnormal ventriculo-arterial connection (HP:0011563)2.02618829
90Muscle stiffness (HP:0003552)2.02396276
91Lactic acidosis (HP:0003128)2.02174470
92Testicular atrophy (HP:0000029)2.01852432
93Respiratory failure (HP:0002878)2.01643260
94Abnormality of the tricuspid valve (HP:0001702)1.98677689
95Rimmed vacuoles (HP:0003805)1.98163120
96Periauricular skin pits (HP:0100277)1.97869114
97Preauricular pit (HP:0004467)1.97869114
98Neoplasm of head and neck (HP:0012288)1.96779399
99Esophageal neoplasm (HP:0100751)1.96779399
100Generalized muscle weakness (HP:0003324)1.96534102
101Congenital malformation of the right heart (HP:0011723)1.92831980
102Double outlet right ventricle (HP:0001719)1.92831980
103Increased intramyocellular lipid droplets (HP:0012240)1.92127165
104Hypoplastic left heart (HP:0004383)1.91222648
105Lymphangioma (HP:0100764)1.88720119
106Diaphragmatic weakness (HP:0009113)1.88425412
107Abnormality of skeletal muscle fiber size (HP:0012084)1.87607251
108Muscular dystrophy (HP:0003560)1.86824535
109Scapular winging (HP:0003691)1.85818239
110Resting tremor (HP:0002322)1.85585173
111Prenatal maternal abnormality (HP:0002686)1.85052416
112Ketosis (HP:0001946)1.83675533
113Multiple enchondromatosis (HP:0005701)1.82073946
114Patent foramen ovale (HP:0001655)1.81036275
115Generalized aminoaciduria (HP:0002909)1.80209552
116Broad metatarsal (HP:0001783)1.79363145
117Skin pits (HP:0100276)1.78440486
118Distal lower limb amyotrophy (HP:0008944)1.77705594
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76408327
120Hyperalaninemia (HP:0003348)1.76408327
121Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76244981
122Truncus arteriosus (HP:0001660)1.70961575
123Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69252254
124Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65006579
125Atrioventricular canal defect (HP:0006695)1.63438297
126Limb hypertonia (HP:0002509)1.62812558
127Muscle fiber inclusion bodies (HP:0100299)1.53858376
128Abnormality of the shoulder girdle musculature (HP:0001435)1.50623223
129Abnormality of the endocardium (HP:0004306)1.46913740
130Maternal diabetes (HP:0009800)1.46047309
131Aneurysm (HP:0002617)1.43771751
132Gowers sign (HP:0003391)1.36819864
133Dysmetric saccades (HP:0000641)1.35153984
134Lower limb amyotrophy (HP:0007210)1.34963235
135Duplication of thumb phalanx (HP:0009942)1.34353559
136Nemaline bodies (HP:0003798)1.31583790
137Childhood onset (HP:0011463)1.27708670
138Proximal amyotrophy (HP:0007126)1.23590118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.59482509
2OBSCN5.03669651
3MYLK4.65234843
4LMTK24.13909735
5PKN23.67474213
6PHKG23.38311165
7PHKG13.38311165
8PDK33.28848481
9PDK43.28848481
10DMPK3.01157029
11STK242.68306099
12TRIB32.56346648
13PIK3CA2.48512711
14TIE12.44729453
15NEK12.31644142
16BCKDK2.20995741
17MUSK1.93987106
18PDK21.90887949
19CDC42BPA1.62155925
20PAK31.52550517
21ILK1.47208043
22ZAK1.41298509
23PINK11.37066250
24PRKD11.37001424
25EPHA41.35114195
26STK38L1.32280989
27GRK71.27234868
28ROCK11.20961317
29DAPK31.20509334
30CAMK2D1.19032759
31STK41.09225291
32TRPM71.08511898
33WNK41.06337053
34FLT31.05026986
35MARK11.03987586
36MAP3K50.92808472
37DDR20.85943868
38MAPK120.85680717
39MAPKAPK30.83863316
40KDR0.80046151
41STK100.79437907
42RIPK10.78150782
43MAP2K30.76903226
44MAP3K70.76389641
45TGFBR20.74574807
46PRKAA10.74518563
47PTK2B0.74308563
48ROCK20.73852391
49MAP3K30.73235037
50CAMK40.71315045
51INSRR0.69017288
52CAMK2A0.67528283
53PDGFRA0.67464927
54PKN10.67208176
55CAMK10.63879337
56EPHA30.63811214
57PRKAA20.62922907
58STK380.60836325
59RPS6KL10.56527776
60RPS6KC10.56527776
61STK390.54424220
62WNK10.54060922
63RAF10.53270718
64PRKACB0.53071993
65PRKCE0.48256573
66ADRBK10.48103606
67RPS6KA60.46385511
68PLK20.45534062
69ITK0.43579964
70LIMK10.43217813
71UHMK10.42675507
72MAPK40.42252630
73CAMK2B0.41216623
74PRKACG0.39136325
75PRKACA0.38958915
76EPHB10.36867304
77EPHB20.35955779
78PRKG20.35527805
79LRRK20.35489509
80PTK60.34496274
81MAP3K100.32683666
82BRSK20.32380830
83PRKD30.30306825
84AKT30.29855522
85PRKCH0.29019945
86FER0.27518289
87PDK10.25041119
88NEK90.24971261
89ICK0.24649903
90PDPK10.24598977
91AKT20.23879493
92NUAK10.23777293
93MAP2K10.22860686
94CAMK2G0.22538993
95LATS10.20985480
96TGFBR10.20818282
97PRKG10.19709281
98STK30.19579128
99RPS6KA10.19293928
100NME20.18799755
101MET0.18507518
102MST40.18123512
103RET0.17703012
104LATS20.17228260
105MAPK70.16702524
106PRKCA0.15031395
107PRKDC0.14943858
108MAP3K60.14079795
109CDK50.13888649
110PAK20.13194235
111PTK20.12934453
112MAP3K110.12738389
113STK110.11739491
114MTOR0.11670757
115TESK10.11306561
116MAPKAPK20.11256011
117SGK20.11010965
118WNK30.09368478
119RPS6KA20.09084671
120RPS6KA30.08625476
121JAK10.08242666
122SGK30.07326559
123FGFR10.06716093
124PRKCQ0.06378813
125NME10.05145320
126PAK60.04574958
127MARK30.04002092
128SGK10.03718127
129FGFR40.02783984

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.14410119
2Cardiac muscle contraction_Homo sapiens_hsa042604.75281092
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.38842482
4Dilated cardiomyopathy_Homo sapiens_hsa054144.02366802
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.94552815
6Parkinsons disease_Homo sapiens_hsa050123.41828348
7Oxidative phosphorylation_Homo sapiens_hsa001903.30277127
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18383756
9Propanoate metabolism_Homo sapiens_hsa006402.96284512
10Fatty acid degradation_Homo sapiens_hsa000712.77544641
11Carbon metabolism_Homo sapiens_hsa012002.53371767
12Alzheimers disease_Homo sapiens_hsa050102.43991625
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.36059987
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.19704121
15Huntingtons disease_Homo sapiens_hsa050162.15598140
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14295555
17Fatty acid metabolism_Homo sapiens_hsa012122.11397999
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91047571
19Pyruvate metabolism_Homo sapiens_hsa006201.82989018
20Viral myocarditis_Homo sapiens_hsa054161.71500020
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55002366
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38694937
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38642552
24Fatty acid elongation_Homo sapiens_hsa000621.35271713
25Butanoate metabolism_Homo sapiens_hsa006501.29459445
26Biosynthesis of amino acids_Homo sapiens_hsa012301.28768226
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09378080
28Mineral absorption_Homo sapiens_hsa049781.09328050
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08080301
30PPAR signaling pathway_Homo sapiens_hsa033200.95289280
31Glucagon signaling pathway_Homo sapiens_hsa049220.93375748
32Insulin resistance_Homo sapiens_hsa049310.89830641
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88627729
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84685469
35Starch and sucrose metabolism_Homo sapiens_hsa005000.83060823
36Focal adhesion_Homo sapiens_hsa045100.79376178
37Adipocytokine signaling pathway_Homo sapiens_hsa049200.77216155
38Tryptophan metabolism_Homo sapiens_hsa003800.72193732
39Arginine biosynthesis_Homo sapiens_hsa002200.69959185
40Insulin signaling pathway_Homo sapiens_hsa049100.68801218
41* HIF-1 signaling pathway_Homo sapiens_hsa040660.64326679
42Lysine degradation_Homo sapiens_hsa003100.63827582
43beta-Alanine metabolism_Homo sapiens_hsa004100.63722556
44Tight junction_Homo sapiens_hsa045300.62167652
45ECM-receptor interaction_Homo sapiens_hsa045120.60592694
46Calcium signaling pathway_Homo sapiens_hsa040200.59945072
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.58152770
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57598718
49Galactose metabolism_Homo sapiens_hsa000520.57551250
50Linoleic acid metabolism_Homo sapiens_hsa005910.57529498
51Phenylalanine metabolism_Homo sapiens_hsa003600.55327133
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.55157502
53Arginine and proline metabolism_Homo sapiens_hsa003300.53448379
54AMPK signaling pathway_Homo sapiens_hsa041520.49628254
55Fructose and mannose metabolism_Homo sapiens_hsa000510.49309403
56Oxytocin signaling pathway_Homo sapiens_hsa049210.48667639
57Regulation of autophagy_Homo sapiens_hsa041400.48232905
58Type II diabetes mellitus_Homo sapiens_hsa049300.45737868
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42133244
60GABAergic synapse_Homo sapiens_hsa047270.41005460
61Peroxisome_Homo sapiens_hsa041460.40759721
62Amphetamine addiction_Homo sapiens_hsa050310.40402440
63Salivary secretion_Homo sapiens_hsa049700.39660582
64Amoebiasis_Homo sapiens_hsa051460.37037300
65Morphine addiction_Homo sapiens_hsa050320.36261892
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35570306
67cAMP signaling pathway_Homo sapiens_hsa040240.35164890
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34911798
69TGF-beta signaling pathway_Homo sapiens_hsa043500.34634807
70Adherens junction_Homo sapiens_hsa045200.33843837
71Renin secretion_Homo sapiens_hsa049240.32749045
72Serotonergic synapse_Homo sapiens_hsa047260.31796616
73Cocaine addiction_Homo sapiens_hsa050300.31142383
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30527595
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.29153656
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.27875757
77Fatty acid biosynthesis_Homo sapiens_hsa000610.27100272
78Gastric acid secretion_Homo sapiens_hsa049710.26596352
79Melanogenesis_Homo sapiens_hsa049160.25684812
80Insulin secretion_Homo sapiens_hsa049110.25665238
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.25223991
82Metabolic pathways_Homo sapiens_hsa011000.25149345
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25143130
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22709485
85Circadian entrainment_Homo sapiens_hsa047130.22150961
86Axon guidance_Homo sapiens_hsa043600.22142787
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21382584
88FoxO signaling pathway_Homo sapiens_hsa040680.19961877
89Hippo signaling pathway_Homo sapiens_hsa043900.19840473
90Melanoma_Homo sapiens_hsa052180.19834315
91Proteoglycans in cancer_Homo sapiens_hsa052050.19318780
92Endometrial cancer_Homo sapiens_hsa052130.18880356
93Thyroid hormone synthesis_Homo sapiens_hsa049180.18667808
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17413836
95Tyrosine metabolism_Homo sapiens_hsa003500.15631779
96Glutamatergic synapse_Homo sapiens_hsa047240.15470618
97Platelet activation_Homo sapiens_hsa046110.14793041
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14650318
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14598613
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14434921
101Arachidonic acid metabolism_Homo sapiens_hsa005900.13499038
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.13489677
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.11189161
104Small cell lung cancer_Homo sapiens_hsa052220.10949476
105Gap junction_Homo sapiens_hsa045400.10722718
106Ovarian steroidogenesis_Homo sapiens_hsa049130.09157820
107Bile secretion_Homo sapiens_hsa049760.08014228
108Renal cell carcinoma_Homo sapiens_hsa052110.07821125
109Circadian rhythm_Homo sapiens_hsa047100.04443050
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.04113730
111Protein digestion and absorption_Homo sapiens_hsa049740.03874751
112Cholinergic synapse_Homo sapiens_hsa047250.01942662
113Pentose phosphate pathway_Homo sapiens_hsa000300.01278999
114Toxoplasmosis_Homo sapiens_hsa051450.01155478
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.01151190
116Rap1 signaling pathway_Homo sapiens_hsa04015-0.0604153
117Estrogen signaling pathway_Homo sapiens_hsa04915-0.0421016
118Pancreatic secretion_Homo sapiens_hsa04972-0.0409943
119mTOR signaling pathway_Homo sapiens_hsa04150-0.0250043
120Fat digestion and absorption_Homo sapiens_hsa04975-0.0109561
121Taste transduction_Homo sapiens_hsa04742-0.0097711
122VEGF signaling pathway_Homo sapiens_hsa04370-0.0022035
123Olfactory transduction_Homo sapiens_hsa04740-0.0022002
124GnRH signaling pathway_Homo sapiens_hsa04912-0.0019133

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