NPPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.73490000
2cardiac myofibril assembly (GO:0055003)9.42285470
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.33761991
4myofibril assembly (GO:0030239)8.09905591
5negative regulation of potassium ion transmembrane transport (GO:1901380)7.39824743
6cardiac muscle contraction (GO:0060048)7.14978517
7cardiac muscle cell development (GO:0055013)6.84399465
8atrioventricular valve morphogenesis (GO:0003181)6.84286914
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.83180560
10muscle filament sliding (GO:0030049)6.75304405
11actin-myosin filament sliding (GO:0033275)6.75304405
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.47256309
13tricarboxylic acid cycle (GO:0006099)6.46434894
14cardiac muscle hypertrophy (GO:0003300)6.45406192
15cardiac cell development (GO:0055006)6.42471991
16cardiac muscle tissue morphogenesis (GO:0055008)6.41817153
17ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.32621542
18regulation of actin filament-based movement (GO:1903115)6.31575438
19regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.28696009
20striated muscle hypertrophy (GO:0014897)6.09374509
21regulation of relaxation of muscle (GO:1901077)6.07514747
22actomyosin structure organization (GO:0031032)6.07051460
23adult heart development (GO:0007512)6.06945107
24plasma membrane repair (GO:0001778)6.05414338
25regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.01660752
26positive regulation of cardiac muscle cell proliferation (GO:0060045)6.00012131
27bundle of His cell to Purkinje myocyte communication (GO:0086069)5.93022302
28ventricular cardiac muscle cell action potential (GO:0086005)5.80253629
29muscle tissue morphogenesis (GO:0060415)5.68533974
30positive regulation of cardiac muscle tissue growth (GO:0055023)5.65641215
31cardiac chamber formation (GO:0003207)5.63955517
32regulation of sarcomere organization (GO:0060297)5.59714420
33cardiac muscle cell proliferation (GO:0060038)5.58604704
34actin-mediated cell contraction (GO:0070252)5.57944158
35heart trabecula formation (GO:0060347)5.57474914
36atrial septum morphogenesis (GO:0060413)5.54455377
37pathway-restricted SMAD protein phosphorylation (GO:0060389)5.47746371
38heart process (GO:0003015)5.42865793
39heart contraction (GO:0060047)5.42865793
40muscle hypertrophy (GO:0014896)5.40102698
41regulation of skeletal muscle contraction (GO:0014819)5.33945120
42negative regulation of muscle hypertrophy (GO:0014741)5.31330216
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.29516567
44striated muscle contraction (GO:0006941)5.25006274
45cardiac ventricle formation (GO:0003211)5.09469701
46regulation of the force of heart contraction (GO:0002026)5.08798439
47regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.08236133
48regulation of striated muscle contraction (GO:0006942)5.07484682
49positive regulation of heart growth (GO:0060421)4.99349013
50regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.99030505
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.96578329
52positive regulation of cardiac muscle tissue development (GO:0055025)4.95261049
53muscle adaptation (GO:0043500)4.93088630
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.91836934
55carnitine shuttle (GO:0006853)4.86090820
56cell communication involved in cardiac conduction (GO:0086065)4.84109060
57regulation of cardiac muscle cell proliferation (GO:0060043)4.82398426
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.81581396
59striated muscle cell proliferation (GO:0014855)4.75917242
60regulation of cell communication by electrical coupling (GO:0010649)4.74144268
61cardiac muscle hypertrophy in response to stress (GO:0014898)4.68714561
62muscle hypertrophy in response to stress (GO:0003299)4.68714561
63cardiac muscle adaptation (GO:0014887)4.68714561
64regulation of membrane repolarization (GO:0060306)4.64139335
65regulation of acyl-CoA biosynthetic process (GO:0050812)4.62028393
66energy coupled proton transport, down electrochemical gradient (GO:0015985)4.56944826
67ATP synthesis coupled proton transport (GO:0015986)4.56944826
68negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.39084901
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.38614009
70regulation of cardiac muscle contraction (GO:0055117)4.30320560
71endocardial cushion development (GO:0003197)4.28459305
72cell communication by electrical coupling (GO:0010644)4.27256337
73respiratory electron transport chain (GO:0022904)4.25022174
74negative regulation of protein localization to cell surface (GO:2000009)4.24133967
75regulation of coenzyme metabolic process (GO:0051196)4.23631075
76regulation of cofactor metabolic process (GO:0051193)4.23631075
77regulation of cardiac muscle cell contraction (GO:0086004)4.23371794
78fatty acid transmembrane transport (GO:1902001)4.21986426
79regulation of cardiac muscle tissue growth (GO:0055021)4.20595647
80actin filament-based movement (GO:0030048)4.19654336
81regulation of cardiac muscle tissue development (GO:0055024)4.15499910
82positive regulation of cardiac muscle hypertrophy (GO:0010613)4.13969306
83positive regulation of muscle hypertrophy (GO:0014742)4.13969306
84electron transport chain (GO:0022900)4.13098239
85regulation of heart rate (GO:0002027)4.09409930
86negative regulation of potassium ion transport (GO:0043267)4.09037990
87ventricular cardiac muscle cell development (GO:0055015)4.08413341
88negative regulation of striated muscle cell apoptotic process (GO:0010664)4.07940885
89muscle cell proliferation (GO:0033002)4.07784204
90cardiac muscle cell action potential involved in contraction (GO:0086002)4.06134373
91regulation of heart growth (GO:0060420)4.04573099
92oxidative phosphorylation (GO:0006119)4.03945575
93regulation of cardioblast differentiation (GO:0051890)4.03510140
94cardiac muscle cell action potential (GO:0086001)4.03428162
95cell migration involved in heart development (GO:0060973)4.02287462
96pericardium development (GO:0060039)4.02206695
97regulation of ATPase activity (GO:0043462)4.00890948
98regulation of ATP catabolic process (GO:1903289)4.00890948
99oxygen transport (GO:0015671)3.99903412
100sarcoplasmic reticulum calcium ion transport (GO:0070296)3.98171099
101fat-soluble vitamin catabolic process (GO:0042363)3.95646549
102vitamin catabolic process (GO:0009111)3.95646549
103positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.94900282
104outflow tract septum morphogenesis (GO:0003148)3.89563421
105regulation of heart contraction (GO:0008016)3.85309993
106NADH metabolic process (GO:0006734)3.83134778
107response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.82611687
108regulation of heart morphogenesis (GO:2000826)3.80594645
109relaxation of cardiac muscle (GO:0055119)3.77862357
110striated muscle cell development (GO:0055002)3.76445091
1112-oxoglutarate metabolic process (GO:0006103)3.67039398
112cardiac muscle tissue development (GO:0048738)3.66001544
113creatine metabolic process (GO:0006600)3.61301663
114embryonic heart tube development (GO:0035050)3.60829318
115carnitine transmembrane transport (GO:1902603)3.57084756
116trabecula formation (GO:0060343)3.55976155
117positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.55923228
118epithelial cell-cell adhesion (GO:0090136)3.51672053
119cardiac conduction (GO:0061337)3.48532897
120positive regulation of organ growth (GO:0046622)3.48472164
121positive regulation of muscle tissue development (GO:1901863)3.47064235
122positive regulation of striated muscle tissue development (GO:0045844)3.46842694
123positive regulation of muscle organ development (GO:0048636)3.46842694
124regulation of sulfur metabolic process (GO:0042762)3.43541256
125negative regulation of myotube differentiation (GO:0010832)3.41653860
126positive regulation of cation channel activity (GO:2001259)3.41393857
127regulation of heart rate by cardiac conduction (GO:0086091)3.41039727
128striated muscle adaptation (GO:0014888)3.37366040
129regulation of muscle contraction (GO:0006937)3.36120439
130negative regulation of cardiac muscle hypertrophy (GO:0010614)3.36092131
131activin receptor signaling pathway (GO:0032924)3.34789046
132positive regulation of heart contraction (GO:0045823)3.32515011
133regulation of calcium ion transmembrane transporter activity (GO:1901019)3.30955106
134regulation of calcium ion transmembrane transport (GO:1903169)3.30955106
135negative regulation of cytosolic calcium ion concentration (GO:0051481)3.29775068
136muscle contraction (GO:0006936)3.29284462
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.28974405
138cardiac septum development (GO:0003279)3.28872720
139regulation of striated muscle cell apoptotic process (GO:0010662)3.28526110
140regulation of secondary heart field cardioblast proliferation (GO:0003266)3.28144557
141regulation of cardioblast proliferation (GO:0003264)3.28144557
142desmosome organization (GO:0002934)3.24680468
143gap junction assembly (GO:0016264)3.20862115
144regulation of glucocorticoid metabolic process (GO:0031943)3.19660768
145endoderm formation (GO:0001706)3.16785270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.97012508
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.53940157
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.91166610
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.91166610
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.91166610
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.80967452
7* TBX20_22328084_ChIP-Seq_HEART_Mouse4.22795386
8* TBX20_22080862_ChIP-Seq_HEART_Mouse4.22795386
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.05978567
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.88589745
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.47244273
12ZNF263_19887448_ChIP-Seq_K562_Human3.32389565
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.20856753
14RARG_19884340_ChIP-ChIP_MEFs_Mouse3.06706518
15ESR1_20079471_ChIP-ChIP_T-47D_Human3.00351297
16* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.60494883
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.28802304
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12936735
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.08956633
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.04891574
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04674177
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.99721866
23EZH2_22144423_ChIP-Seq_EOC_Human1.98242511
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93082752
25NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.92126707
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.92078567
27PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.89108998
28CLOCK_20551151_ChIP-Seq_293T_Human1.85693832
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83651546
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82707230
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78539334
32* EOMES_21245162_ChIP-Seq_HESCs_Human1.76602785
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75298515
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75298515
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.70338305
36SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.69484129
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67036561
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66543106
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64144667
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60110326
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60100505
42TCF3_18692474_ChIP-Seq_MESCs_Mouse1.58313479
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56596670
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54516835
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45132635
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44865033
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.44232628
48GATA1_22025678_ChIP-Seq_K562_Human1.38016382
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37998600
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35396452
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35311098
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.35255205
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33800119
54* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32615906
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29954673
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.28480569
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.28014687
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26849071
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24896103
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24555490
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24076120
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23342918
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.23262097
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22870514
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21337746
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20989654
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20806578
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.19917493
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19759947
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18860980
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17633748
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.17618413
73ATF3_27146783_Chip-Seq_COLON_Human1.17607084
74* CTCF_27219007_Chip-Seq_Bcells_Human1.17238127
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17119033
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16373885
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16039952
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16033822
79LXR_22158963_ChIP-Seq_LIVER_Mouse1.14572216
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13575915
81TP63_22573176_ChIP-Seq_HFKS_Human1.12777978
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.11820624
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11586483
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10126275
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09637429
86KDM2B_26808549_Chip-Seq_DND41_Human1.09555899
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08141478
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.07877427
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06570982
90* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06122753
91RACK7_27058665_Chip-Seq_MCF-7_Human1.04400622
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.02408232
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01928604
94LXR_22292898_ChIP-Seq_THP-1_Human1.01492759
95* SPI1_20517297_ChIP-Seq_HL60_Human1.01012559
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00515381
97ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00463491
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00091664
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99456478
100RUNX1_27514584_Chip-Seq_MCF-7_Human0.99281684
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99103779
102TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98223982
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98211913
104* GATA1_19941826_ChIP-Seq_K562_Human0.97048490
105RING1B_27294783_Chip-Seq_NPCs_Mouse0.96407229
106SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96275756
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96162308
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95664576
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94854917
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94183870
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.93784018
112ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92548352
113* KDM2B_26808549_Chip-Seq_K562_Human0.92254746
114CJUN_26792858_Chip-Seq_BT549_Human0.91098167
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90582194
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90386360
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90240672
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.90123079
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89726185
120SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89069890
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88013022
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87635334
123PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86656330
124DROSHA_22980978_ChIP-Seq_HELA_Human0.86281449
125ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85993671
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.85062524
127P68_20966046_ChIP-Seq_HELA_Human0.85043318
128RXR_22158963_ChIP-Seq_LIVER_Mouse0.84510439
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.84495301
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84025342
131EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83472510
132ZNF274_21170338_ChIP-Seq_K562_Hela0.81819177
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.81707251
134TP53_23651856_ChIP-Seq_MEFs_Mouse0.81284286
135TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80995709
136OCT4_20526341_ChIP-Seq_ESCs_Human0.80833203
137FOXH1_21741376_ChIP-Seq_ESCs_Human0.80642889
138* GATA2_19941826_ChIP-Seq_K562_Human0.80484503
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77860039
140BCOR_27268052_Chip-Seq_Bcells_Human0.75393198
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.74473640
142EGR1_19032775_ChIP-ChIP_M12_Human0.74020901
143LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73967783
144GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73957413
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.73850886
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.73083713
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.73043043
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72113798
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.72055241
150BCL6_27268052_Chip-Seq_Bcells_Human0.71805249
151SPI1_23127762_ChIP-Seq_K562_Human0.71653154
152SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70584659
153BCAT_22108803_ChIP-Seq_LS180_Human0.70395394
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.69906415
155* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.69227398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ8.94548129
2MP0002837_dystrophic_cardiac_calcinosis7.45377272
3MP0004084_abnormal_cardiac_muscle6.25850861
4MP0003646_muscle_fatigue5.35187430
5MP0000751_myopathy5.00320881
6MP0004215_abnormal_myocardial_fiber4.88663158
7MP0004036_abnormal_muscle_relaxation4.31050971
8MP0005330_cardiomyopathy4.17026994
9MP0000749_muscle_degeneration3.74419836
10MP0008775_abnormal_heart_ventricle3.40538673
11MP0002972_abnormal_cardiac_muscle3.30312934
12MP0004133_heterotaxia3.20434640
13* MP0004087_abnormal_muscle_fiber2.97265705
14MP0003137_abnormal_impulse_conducting2.93178779
15MP0005385_cardiovascular_system_phenoty2.80078224
16MP0001544_abnormal_cardiovascular_syste2.80078224
17MP0008004_abnormal_stomach_pH2.64883839
18* MP0010630_abnormal_cardiac_muscle2.63502287
19MP0005620_abnormal_muscle_contractility2.60211483
20MP0006138_congestive_heart_failure2.58851818
21MP0000750_abnormal_muscle_regeneration2.54763935
22MP0004484_altered_response_of2.42961645
23MP0003828_pulmonary_edema2.37547965
24MP0004130_abnormal_muscle_cell2.32194583
25MP0004085_abnormal_heartbeat2.27548429
26MP0002106_abnormal_muscle_physiology2.26817109
27MP0002269_muscular_atrophy2.19786430
28MP0003221_abnormal_cardiomyocyte_apopto2.17754752
29MP0004510_myositis2.01928883
30MP0003950_abnormal_plasma_membrane1.88987841
31MP0003136_yellow_coat_color1.88939284
32MP0000462_abnormal_digestive_system1.87485562
33MP0002127_abnormal_cardiovascular_syste1.84272045
34MP0005369_muscle_phenotype1.82017325
35MP0010030_abnormal_orbit_morphology1.81708150
36MP0000747_muscle_weakness1.74625612
37MP0003119_abnormal_digestive_system1.73975046
38MP0000759_abnormal_skeletal_muscle1.73023970
39MP0006036_abnormal_mitochondrial_physio1.59267131
40MP0004233_abnormal_muscle_weight1.50916251
41MP0004145_abnormal_muscle_electrophysio1.48918105
42MP0001348_abnormal_lacrimal_gland1.32004167
43MP0000343_altered_response_to1.31179812
44MP0003279_aneurysm1.29017949
45MP0003385_abnormal_body_wall1.27895849
46MP0005666_abnormal_adipose_tissue1.21044243
47MP0003567_abnormal_fetal_cardiomyocyte1.21013551
48MP0005394_taste/olfaction_phenotype1.20965644
49MP0005499_abnormal_olfactory_system1.20965644
50MP0002332_abnormal_exercise_endurance1.19526302
51MP0010368_abnormal_lymphatic_system1.19157980
52MP0005165_increased_susceptibility_to1.15799758
53MP0002163_abnormal_gland_morphology1.15387485
54* MP0000266_abnormal_heart_morphology1.14748727
55MP0005670_abnormal_white_adipose1.11905314
56MP0005503_abnormal_tendon_morphology1.08946925
57MP0003806_abnormal_nucleotide_metabolis1.06506709
58MP0006035_abnormal_mitochondrial_morpho0.99018685
59MP0002234_abnormal_pharynx_morphology0.98764613
60MP0003937_abnormal_limbs/digits/tail_de0.93068619
61MP0000428_abnormal_craniofacial_morphol0.92711160
62MP0003566_abnormal_cell_adhesion0.90343144
63MP0005623_abnormal_meninges_morphology0.89555856
64MP0002128_abnormal_blood_circulation0.87794207
65MP0000230_abnormal_systemic_arterial0.83862227
66MP0001661_extended_life_span0.81916787
67MP0003890_abnormal_embryonic-extraembry0.81454185
68MP0005266_abnormal_metabolism0.79798126
69MP0003705_abnormal_hypodermis_morpholog0.78256791
70MP0005375_adipose_tissue_phenotype0.78126233
71MP0000767_abnormal_smooth_muscle0.77944935
72MP0004185_abnormal_adipocyte_glucose0.77915402
73MP0002233_abnormal_nose_morphology0.71019888
74MP0008438_abnormal_cutaneous_collagen0.70574164
75MP0004272_abnormal_basement_membrane0.70221532
76MP0005451_abnormal_body_composition0.69030690
77MP0002108_abnormal_muscle_morphology0.67012484
78MP0003935_abnormal_craniofacial_develop0.66338743
79MP0000762_abnormal_tongue_morphology0.65096082
80MP0001879_abnormal_lymphatic_vessel0.63292713
81MP0002909_abnormal_adrenal_gland0.62969803
82MP0002254_reproductive_system_inflammat0.61603011
83MP0003941_abnormal_skin_development0.59931211
84MP0002084_abnormal_developmental_patter0.55692093
85MP0005379_endocrine/exocrine_gland_phen0.53468993
86MP0001299_abnormal_eye_distance/0.52432712
87MP0002090_abnormal_vision0.51289079
88MP0003122_maternal_imprinting0.50208731
89MP0002925_abnormal_cardiovascular_devel0.47440799
90MP0003984_embryonic_growth_retardation0.47349291
91MP0005275_abnormal_skin_tensile0.47344076
92MP0002088_abnormal_embryonic_growth/wei0.46041677
93MP0005508_abnormal_skeleton_morphology0.45481374
94MP0005319_abnormal_enzyme/_coenzyme0.43898420
95MP0003091_abnormal_cell_migration0.43885394
96MP0000003_abnormal_adipose_tissue0.43395125
97MP0001730_embryonic_growth_arrest0.43348242
98MP0000733_abnormal_muscle_development0.43185831
99MP0002086_abnormal_extraembryonic_tissu0.42681478
100MP0002132_abnormal_respiratory_system0.42421183
101MP0005187_abnormal_penis_morphology0.42147593
102MP0000013_abnormal_adipose_tissue0.41861043
103MP0002277_abnormal_respiratory_mucosa0.41422874
104MP0004147_increased_porphyrin_level0.41167804
105MP0001614_abnormal_blood_vessel0.39848508
106MP0004043_abnormal_pH_regulation0.37987685
107MP0002078_abnormal_glucose_homeostasis0.36785349
108MP0002085_abnormal_embryonic_tissue0.36013409
109MP0001784_abnormal_fluid_regulation0.35275459
110MP0009384_cardiac_valve_regurgitation0.34748133
111MP0002971_abnormal_brown_adipose0.34467445
112MP0001958_emphysema0.33757421
113MP0001727_abnormal_embryo_implantation0.28956118
114MP0009840_abnormal_foam_cell0.28721419
115MP0005595_abnormal_vascular_smooth0.28076288
116MP0002295_abnormal_pulmonary_circulatio0.27104816
117MP0005380_embryogenesis_phenotype0.25963076
118MP0001672_abnormal_embryogenesis/_devel0.25963076
119MP0004924_abnormal_behavior0.25705193
120MP0005386_behavior/neurological_phenoty0.25705193
121MP0005167_abnormal_blood-brain_barrier0.25526384
122MP0005535_abnormal_body_temperature0.25493987
123MP0003948_abnormal_gas_homeostasis0.25395157
124MP0000249_abnormal_blood_vessel0.24612954
125MP0002133_abnormal_respiratory_system0.23282032
126MP0005388_respiratory_system_phenotype0.23282032
127MP0005584_abnormal_enzyme/coenzyme_acti0.22063171
128MP0003045_fibrosis0.21160620
129MP0005083_abnormal_biliary_tract0.19188398
130MP0008961_abnormal_basal_metabolism0.18310037
131MP0002877_abnormal_melanocyte_morpholog0.18213748
132MP0005376_homeostasis/metabolism_phenot0.18021248
133MP0005334_abnormal_fat_pad0.17711339
134MP0005332_abnormal_amino_acid0.17407709

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.55382029
2Ventricular tachycardia (HP:0004756)7.47519026
3Atrial fibrillation (HP:0005110)6.61428556
4Calf muscle hypertrophy (HP:0008981)6.41142944
5Primary atrial arrhythmia (HP:0001692)6.19154868
6Supraventricular tachycardia (HP:0004755)5.99777486
7Supraventricular arrhythmia (HP:0005115)5.88589170
8Lipoatrophy (HP:0100578)5.77186638
9Muscle fiber splitting (HP:0003555)5.73283870
10Muscle hypertrophy of the lower extremities (HP:0008968)5.67823064
11Exercise-induced muscle cramps (HP:0003710)5.49661638
12Abnormality of the calf musculature (HP:0001430)5.45742057
13Right ventricular cardiomyopathy (HP:0011663)5.39511041
14Abnormality of the left ventricular outflow tract (HP:0011103)5.27319663
15Subaortic stenosis (HP:0001682)5.27319663
16Hyporeflexia of lower limbs (HP:0002600)5.26313620
17Exercise-induced myalgia (HP:0003738)5.15338392
18Syncope (HP:0001279)4.82322074
19Dilated cardiomyopathy (HP:0001644)4.71404270
20Hypoplastic left heart (HP:0004383)4.64983392
21Palpitations (HP:0001962)4.64688479
22Bundle branch block (HP:0011710)4.61679613
23Periauricular skin pits (HP:0100277)4.45386186
24Preauricular pit (HP:0004467)4.45386186
25Myoglobinuria (HP:0002913)4.32504210
26Prolonged QT interval (HP:0001657)4.27214415
27Asymmetric septal hypertrophy (HP:0001670)4.24519241
28Ventricular arrhythmia (HP:0004308)4.17907146
29EMG: myopathic abnormalities (HP:0003458)4.15142600
30Abnormal ventriculo-arterial connection (HP:0011563)3.91954325
31Transposition of the great arteries (HP:0001669)3.91954325
32Abnormal connection of the cardiac segments (HP:0011545)3.91954325
33Heart block (HP:0012722)3.78810150
34Increased connective tissue (HP:0009025)3.74543746
35Atrioventricular block (HP:0001678)3.66631049
36Hypoplastic heart (HP:0001961)3.62103272
37Abnormal atrioventricular conduction (HP:0005150)3.59882655
38Ventricular fibrillation (HP:0001663)3.57789842
39Skin pits (HP:0100276)3.38761416
40Rhabdomyolysis (HP:0003201)3.31034678
41Myotonia (HP:0002486)3.25370242
42Patent foramen ovale (HP:0001655)3.19825280
43Acute necrotizing encephalopathy (HP:0006965)3.13603978
44Abnormal mitochondria in muscle tissue (HP:0008316)3.13565644
45Hepatic necrosis (HP:0002605)3.09660711
46Abnormal EKG (HP:0003115)3.08128216
47Left ventricular hypertrophy (HP:0001712)2.97436610
48Distal lower limb muscle weakness (HP:0009053)2.95308176
49Difficulty running (HP:0009046)2.90973894
50Partial duplication of thumb phalanx (HP:0009944)2.90028376
51Palmoplantar keratoderma (HP:0000982)2.87904432
52Difficulty climbing stairs (HP:0003551)2.77849384
53Hepatocellular necrosis (HP:0001404)2.73265107
54Ketoacidosis (HP:0001993)2.71685117
55Hypoglycemic coma (HP:0001325)2.69627214
56Acute encephalopathy (HP:0006846)2.67924099
57Abnormality of the tricuspid valve (HP:0001702)2.61079499
58Progressive macrocephaly (HP:0004481)2.59108030
59Mitochondrial inheritance (HP:0001427)2.57387789
60Ragged-red muscle fibers (HP:0003200)2.55203791
61Conjunctival hamartoma (HP:0100780)2.54902242
62Partial duplication of the phalanx of hand (HP:0009999)2.49537963
63Cerebral edema (HP:0002181)2.48825745
64Areflexia of lower limbs (HP:0002522)2.46885281
65Testicular atrophy (HP:0000029)2.44271491
66Increased CSF lactate (HP:0002490)2.43938139
67Limb-girdle muscle atrophy (HP:0003797)2.41591677
68Abnormality of the foot musculature (HP:0001436)2.39022542
69Neck muscle weakness (HP:0000467)2.38279011
70Pheochromocytoma (HP:0002666)2.35491896
71Increased muscle lipid content (HP:0009058)2.34075829
72Abnormality of fatty-acid metabolism (HP:0004359)2.33329459
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32150302
74Dicarboxylic aciduria (HP:0003215)2.32150302
75Anomalous pulmonary venous return (HP:0010772)2.30403104
76Aplasia of the musculature (HP:0100854)2.29312592
77Truncus arteriosus (HP:0001660)2.26703579
78Abnormality of the pubic bones (HP:0003172)2.24509735
79Sudden cardiac death (HP:0001645)2.23013381
80Foot dorsiflexor weakness (HP:0009027)2.22641177
81Respiratory failure (HP:0002878)2.20348277
82Increased variability in muscle fiber diameter (HP:0003557)2.19929023
83Neoplasm of the adrenal gland (HP:0100631)2.16606620
84Lactic acidosis (HP:0003128)2.14360027
85Exercise intolerance (HP:0003546)2.12855253
86Congestive heart failure (HP:0001635)2.12545918
87Abnormality of the fetal cardiovascular system (HP:0010948)2.11923666
88Abnormal umbilical cord blood vessels (HP:0011403)2.11923666
89Single umbilical artery (HP:0001195)2.11923666
90Neuroendocrine neoplasm (HP:0100634)2.11167453
91Increased intramyocellular lipid droplets (HP:0012240)2.09230580
92Lower limb amyotrophy (HP:0007210)2.08379552
93Wrist flexion contracture (HP:0001239)2.07378299
94Muscle stiffness (HP:0003552)2.06642256
95Distal lower limb amyotrophy (HP:0008944)2.05400749
96Abnormal pancreas size (HP:0012094)2.05065494
97Short humerus (HP:0005792)2.03190001
98EMG: neuropathic changes (HP:0003445)2.02991166
99Hamartoma of the eye (HP:0010568)2.01570831
100Complete atrioventricular canal defect (HP:0001674)1.99886289
101Ureteral duplication (HP:0000073)1.99601470
102Ketosis (HP:0001946)1.97841646
103Mildly elevated creatine phosphokinase (HP:0008180)1.96939430
104Abnormality of the pulmonary veins (HP:0011718)1.96284688
105Abnormality of skeletal muscle fiber size (HP:0012084)1.94379249
106Bradycardia (HP:0001662)1.94096613
107Maternal diabetes (HP:0009800)1.93364860
108Rimmed vacuoles (HP:0003805)1.92854533
109Muscular dystrophy (HP:0003560)1.90249626
110Aplasia/hypoplasia of the humerus (HP:0006507)1.89459844
111Hyperalaninemia (HP:0003348)1.88674312
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88674312
113Abnormality of alanine metabolism (HP:0010916)1.88674312
114Neoplasm of head and neck (HP:0012288)1.87554419
115Esophageal neoplasm (HP:0100751)1.87554419
116Dysmetric saccades (HP:0000641)1.87264236
117Abnormality of the umbilical cord (HP:0010881)1.86014168
118Increased serum pyruvate (HP:0003542)1.83186875
119Abnormality of glycolysis (HP:0004366)1.83186875
120Pulmonary artery stenosis (HP:0004415)1.83132032
121Hyperinsulinemic hypoglycemia (HP:0000825)1.83057989
122Double outlet right ventricle (HP:0001719)1.82993770
123Congenital malformation of the right heart (HP:0011723)1.82993770
124Preaxial foot polydactyly (HP:0001841)1.82727923
125Premature rupture of membranes (HP:0001788)1.81172660
126Diaphragmatic weakness (HP:0009113)1.81030689
127Lymphangioma (HP:0100764)1.80715991
128Abnormality of the aortic arch (HP:0012303)1.78801922
129Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75558359
130Centrally nucleated skeletal muscle fibers (HP:0003687)1.74943512
131Scapular winging (HP:0003691)1.74392884
132Tinnitus (HP:0000360)1.74373154
133Gowers sign (HP:0003391)1.74110370
134Dislocated radial head (HP:0003083)1.72855962
135Abnormality of the right ventricle (HP:0001707)1.72301418
136Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.70051720
137Atrioventricular canal defect (HP:0006695)1.66754205
138Soft skin (HP:0000977)1.62254057
139Vitreoretinal degeneration (HP:0000655)1.61887324
140Abnormality of the radial head (HP:0003995)1.59583123
141Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.58982080
142Coarctation of aorta (HP:0001680)1.55062919
143Testicular neoplasm (HP:0010788)1.53295008
144Bulbar palsy (HP:0001283)1.51724015
145Aplasia/Hypoplasia of the sacrum (HP:0008517)1.50603015
146Muscle fiber inclusion bodies (HP:0100299)1.50397108
147Absent eyebrow (HP:0002223)1.45661500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.93642389
2LMTK24.49998888
3MYLK4.33513540
4OBSCN4.19588062
5PHKG23.68875825
6PHKG13.68875825
7PDK33.35753103
8PDK43.35753103
9PKN23.34797674
10DMPK2.97232608
11TRIB32.53401239
12BCKDK2.47316991
13NEK12.40607403
14MUSK2.40414425
15PIK3CA2.35529529
16TIE12.34224809
17PDK21.99646476
18MAP3K101.89017730
19STK241.87766684
20PINK11.67007412
21PAK31.60700828
22CDC42BPA1.49890542
23MAP3K91.46275144
24PRKD11.45133316
25ARAF1.40659587
26GRK71.36353595
27CAMK2D1.31532977
28MAPKAPK31.27536008
29EPHA21.26204127
30DAPK31.23353260
31ILK1.21382429
32ROCK11.19655543
33STK38L1.19432743
34ZAK1.17106781
35EPHA41.10710803
36STK41.09757527
37PAK40.94332211
38MARK10.92809065
39FLT30.90667232
40TRPM70.90288325
41WNK40.89872994
42MAP3K50.89358884
43PKN10.88687979
44RIPK10.82453160
45MAPK120.82330039
46MAP3K30.80797404
47DDR20.80251973
48PRKAA10.78706736
49KDR0.77976269
50PDGFRA0.77958957
51KSR20.77235600
52PTK20.77016460
53ROCK20.75447851
54INSRR0.73304300
55CAMK40.72785740
56PAK20.70782579
57MAP3K60.69644205
58PRKAA20.68665657
59RPS6KL10.67481802
60RPS6KC10.67481802
61STK380.67315276
62MAP3K70.64865925
63CAMK2A0.63729356
64MAPK40.63582804
65TYRO30.60112038
66MOS0.59795522
67PRKCE0.59567148
68RPS6KA60.56484482
69STK110.54732152
70ERBB40.53784314
71PTK2B0.53753081
72TGFBR20.52522829
73PRKACB0.51843504
74WNK10.51330747
75PRKD30.51044124
76MAP2K30.50140654
77NME20.49691497
78MAPK70.49367145
79EPHB10.49060375
80CAMK10.48283359
81MAP3K130.47701993
82CDK40.46564250
83MARK20.45939947
84RPS6KB20.44230212
85RAF10.43394711
86PRKACG0.41876610
87PRKACA0.40798551
88CAMK2B0.39534486
89PRKCH0.39095178
90MET0.38146078
91NTRK30.37957396
92TESK10.37473296
93NEK90.37392128
94NTRK10.37122036
95STK390.35415709
96EPHB20.34965349
97FER0.34501014
98KSR10.33517657
99BRAF0.32493701
100PRKG20.32361165
101ICK0.31086322
102LATS20.30795551
103PDPK10.30484874
104PTK60.29658122
105RPS6KA10.28608406
106CAMK2G0.28211956
107LRRK20.26527048
108PDK10.26095135
109AKT20.25492302
110SRC0.24702001
111NME10.24363273
112RET0.22473586
113LIMK10.20392778
114MTOR0.19936209
115SGK30.19640154
116PRKG10.19429741
117RPS6KA20.18117159
118MAPKAPK20.17985857
119MARK30.15143327
120EPHA30.14918462
121JAK10.13183479
122TGFBR10.12709473
123PDGFRB0.11672759
124UHMK10.10317312
125MAP2K10.10056396
126FGFR40.09978589
127RPS6KA30.09621028
128LATS10.08247050
129SGK10.07677021
130ADRBK10.05805380
131PRKCD0.05706354

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.93960118
2Cardiac muscle contraction_Homo sapiens_hsa042604.57131790
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.29102478
4Dilated cardiomyopathy_Homo sapiens_hsa054143.88576920
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.79753627
6Parkinsons disease_Homo sapiens_hsa050123.49545540
7Oxidative phosphorylation_Homo sapiens_hsa001903.46375198
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38898829
9Propanoate metabolism_Homo sapiens_hsa006403.07190293
10TGF-beta signaling pathway_Homo sapiens_hsa043502.94036762
11Fatty acid degradation_Homo sapiens_hsa000712.76183722
12Alzheimers disease_Homo sapiens_hsa050102.54348116
13Carbon metabolism_Homo sapiens_hsa012002.47655167
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.36554582
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.32304560
16Huntingtons disease_Homo sapiens_hsa050162.23898202
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21932010
18Fatty acid metabolism_Homo sapiens_hsa012122.09218125
19Pyruvate metabolism_Homo sapiens_hsa006201.80561741
20Viral myocarditis_Homo sapiens_hsa054161.77572434
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72233187
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47352684
23Butanoate metabolism_Homo sapiens_hsa006501.41277719
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36664331
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35276614
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29419176
27Fatty acid elongation_Homo sapiens_hsa000621.29176565
28Melanoma_Homo sapiens_hsa052181.29138659
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26973034
30Basal cell carcinoma_Homo sapiens_hsa052171.19409047
31Biosynthesis of amino acids_Homo sapiens_hsa012301.16619882
32Hippo signaling pathway_Homo sapiens_hsa043901.15527926
33Protein digestion and absorption_Homo sapiens_hsa049741.09695574
34PPAR signaling pathway_Homo sapiens_hsa033201.04560902
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94903865
36Insulin resistance_Homo sapiens_hsa049310.92349627
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90321457
38Glucagon signaling pathway_Homo sapiens_hsa049220.89748831
39Wnt signaling pathway_Homo sapiens_hsa043100.88295044
40Starch and sucrose metabolism_Homo sapiens_hsa005000.86880284
41Melanogenesis_Homo sapiens_hsa049160.86005624
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85413687
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.84840098
44* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82222067
45HIF-1 signaling pathway_Homo sapiens_hsa040660.80888787
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79221679
47Insulin signaling pathway_Homo sapiens_hsa049100.77313603
48Focal adhesion_Homo sapiens_hsa045100.75326054
49Tryptophan metabolism_Homo sapiens_hsa003800.74596893
50Arginine biosynthesis_Homo sapiens_hsa002200.73707993
51Axon guidance_Homo sapiens_hsa043600.73177391
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72073101
53Pathways in cancer_Homo sapiens_hsa052000.67668743
54Lysine degradation_Homo sapiens_hsa003100.64390589
55beta-Alanine metabolism_Homo sapiens_hsa004100.64122450
56Calcium signaling pathway_Homo sapiens_hsa040200.62940760
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62624052
58Arginine and proline metabolism_Homo sapiens_hsa003300.61522857
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.60751198
60Prion diseases_Homo sapiens_hsa050200.59661734
61Galactose metabolism_Homo sapiens_hsa000520.56755544
62Type II diabetes mellitus_Homo sapiens_hsa049300.56650016
63Endometrial cancer_Homo sapiens_hsa052130.55672910
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55205278
65ECM-receptor interaction_Homo sapiens_hsa045120.54778016
66Tight junction_Homo sapiens_hsa045300.54738759
67AMPK signaling pathway_Homo sapiens_hsa041520.54442651
68Phenylalanine metabolism_Homo sapiens_hsa003600.54320147
69MAPK signaling pathway_Homo sapiens_hsa040100.53938232
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.52514760
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51238951
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.47365383
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46191495
74Peroxisome_Homo sapiens_hsa041460.43693093
75Hedgehog signaling pathway_Homo sapiens_hsa043400.42492315
76Thyroid hormone synthesis_Homo sapiens_hsa049180.41892342
77Oxytocin signaling pathway_Homo sapiens_hsa049210.41464419
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41360948
79Bladder cancer_Homo sapiens_hsa052190.41266582
80Fructose and mannose metabolism_Homo sapiens_hsa000510.40037073
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37920162
82Amoebiasis_Homo sapiens_hsa051460.36541546
83cAMP signaling pathway_Homo sapiens_hsa040240.35875694
84GABAergic synapse_Homo sapiens_hsa047270.35854740
85Ras signaling pathway_Homo sapiens_hsa040140.33807610
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33422215
87Adherens junction_Homo sapiens_hsa045200.32094950
88Retinol metabolism_Homo sapiens_hsa008300.31487183
89Insulin secretion_Homo sapiens_hsa049110.30826200
90Fatty acid biosynthesis_Homo sapiens_hsa000610.30760235
91Renin secretion_Homo sapiens_hsa049240.30075376
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29138352
93Linoleic acid metabolism_Homo sapiens_hsa005910.28653205
94Mineral absorption_Homo sapiens_hsa049780.27800060
95Metabolic pathways_Homo sapiens_hsa011000.27647800
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25803681
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.24781606
98FoxO signaling pathway_Homo sapiens_hsa040680.24383536
99Gastric acid secretion_Homo sapiens_hsa049710.22844162
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22578786
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.19357509
102Tyrosine metabolism_Homo sapiens_hsa003500.17747869
103Proteoglycans in cancer_Homo sapiens_hsa052050.17549619
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17390284
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15948492
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14831252
107Renal cell carcinoma_Homo sapiens_hsa052110.14549010
108Circadian entrainment_Homo sapiens_hsa047130.14340209
109Gap junction_Homo sapiens_hsa045400.12322512
110Taste transduction_Homo sapiens_hsa047420.11719305
111Platelet activation_Homo sapiens_hsa046110.08010330
112Fat digestion and absorption_Homo sapiens_hsa049750.06800353
113Small cell lung cancer_Homo sapiens_hsa052220.06698469
114VEGF signaling pathway_Homo sapiens_hsa043700.06056048
115Bile secretion_Homo sapiens_hsa049760.05509574
116mTOR signaling pathway_Homo sapiens_hsa041500.05168931
117Ovarian steroidogenesis_Homo sapiens_hsa049130.04658494
118Toxoplasmosis_Homo sapiens_hsa051450.04086307
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03617195
120Circadian rhythm_Homo sapiens_hsa047100.02294263
121Dorso-ventral axis formation_Homo sapiens_hsa043200.02043374
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.01354467
123Cholinergic synapse_Homo sapiens_hsa047250.01286923
124GnRH signaling pathway_Homo sapiens_hsa049120.01235290
125Rap1 signaling pathway_Homo sapiens_hsa04015-0.0365692
126Estrogen signaling pathway_Homo sapiens_hsa04915-0.0305152
127Pentose phosphate pathway_Homo sapiens_hsa00030-0.0238151
128Glycerolipid metabolism_Homo sapiens_hsa00561-0.0123121
129Pancreatic secretion_Homo sapiens_hsa04972-0.0024630

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