NPR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)7.61925212
2triglyceride catabolic process (GO:0019433)6.99977546
3gonadal mesoderm development (GO:0007506)6.45497496
4glomerular visceral epithelial cell development (GO:0072015)6.42421707
5neutral lipid catabolic process (GO:0046461)6.39115483
6acylglycerol catabolic process (GO:0046464)6.39115483
7positive regulation of male gonad development (GO:2000020)5.81009420
8glomerular epithelial cell development (GO:0072310)5.72368946
9surfactant homeostasis (GO:0043129)5.62504105
10sex determination (GO:0007530)5.12179109
11regulation of male gonad development (GO:2000018)5.10844002
12NADH metabolic process (GO:0006734)4.88740482
13vascular endothelial growth factor signaling pathway (GO:0038084)4.69794385
14glycerolipid catabolic process (GO:0046503)4.51208303
15low-density lipoprotein particle clearance (GO:0034383)4.50305537
16C21-steroid hormone biosynthetic process (GO:0006700)4.39934971
17negative regulation of granulocyte differentiation (GO:0030853)4.36463374
18fatty acid homeostasis (GO:0055089)4.23722406
19transcytosis (GO:0045056)4.22011451
20chemical homeostasis within a tissue (GO:0048875)4.19015414
21basement membrane organization (GO:0071711)4.13987901
22diacylglycerol metabolic process (GO:0046339)4.11191339
23cellular response to epinephrine stimulus (GO:0071872)4.10039637
24androgen biosynthetic process (GO:0006702)4.01081445
25polyol transport (GO:0015791)4.00248098
26barbed-end actin filament capping (GO:0051016)3.89134988
27apoptotic cell clearance (GO:0043277)3.87848893
28lymphangiogenesis (GO:0001946)3.86670657
29cGMP-mediated signaling (GO:0019934)3.85774193
30glomerulus development (GO:0032835)3.83397594
31lipid storage (GO:0019915)3.79629484
32alpha-linolenic acid metabolic process (GO:0036109)3.78780701
33cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.71019194
34adhesion of symbiont to host (GO:0044406)3.70345284
35renal filtration (GO:0097205)3.66560664
36cellular response to growth hormone stimulus (GO:0071378)3.62436991
37glucocorticoid biosynthetic process (GO:0006704)3.62392184
38regulation of cholesterol storage (GO:0010885)3.60009703
39retina vasculature morphogenesis in camera-type eye (GO:0061299)3.58048090
40positive regulation of glomerulus development (GO:0090193)3.53374437
41cellular response to interferon-alpha (GO:0035457)3.51708334
42positive regulation of cholesterol efflux (GO:0010875)3.49353760
43cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.48474754
44blood vessel endothelial cell migration (GO:0043534)3.47783683
45negative regulation of gluconeogenesis (GO:0045721)3.47304793
46lymph vessel development (GO:0001945)3.43183266
47cell migration involved in sprouting angiogenesis (GO:0002042)3.41820423
48positive regulation of p38MAPK cascade (GO:1900745)3.41700179
49response to epinephrine (GO:0071871)3.41575361
50urea cycle (GO:0000050)3.40323712
51dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.38787579
52fatty acid transmembrane transport (GO:1902001)3.38510883
53tricarboxylic acid metabolic process (GO:0072350)3.37762203
54positive regulation of vasculogenesis (GO:2001214)3.37037987
55white fat cell differentiation (GO:0050872)3.35440804
56endothelial cell chemotaxis (GO:0035767)3.34502219
57regulation of p38MAPK cascade (GO:1900744)3.34073275
58glomerular filtration (GO:0003094)3.33522236
59regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.33218527
60adhesion of symbiont to host cell (GO:0044650)3.32409822
61virion attachment to host cell (GO:0019062)3.32409822
62renal system process involved in regulation of blood volume (GO:0001977)3.30848662
63negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.30651753
64regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28312666
65blood vessel maturation (GO:0001955)3.27071539
66negative regulation of complement activation (GO:0045916)3.23819967
67angiogenesis involved in wound healing (GO:0060055)3.23733225
68endothelial tube morphogenesis (GO:0061154)3.23265228
69morphogenesis of an endothelium (GO:0003159)3.23265228
70negative regulation of metanephros development (GO:0072217)3.21443192
71negative regulation of macrophage differentiation (GO:0045650)3.20879366
72negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.18278144
73anatomical structure regression (GO:0060033)3.17822174
74venous blood vessel morphogenesis (GO:0048845)3.17425736
75oxaloacetate metabolic process (GO:0006107)3.17251501
76positive regulation of protein kinase C signaling (GO:0090037)3.16789883
77cellular response to cadmium ion (GO:0071276)3.16150552
78carnitine shuttle (GO:0006853)3.16109281
79endocrine hormone secretion (GO:0060986)3.15854639
80response to dietary excess (GO:0002021)3.13860510
81regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.13087034
82triglyceride metabolic process (GO:0006641)3.11714570
83plasma lipoprotein particle clearance (GO:0034381)3.11226487
84keratan sulfate catabolic process (GO:0042340)3.11021435
85Leydig cell differentiation (GO:0033327)3.10717691
86positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.09974026
87regulation of gonadotropin secretion (GO:0032276)3.09932444
88macroautophagy (GO:0016236)3.09097691
89regulation of glycogen (starch) synthase activity (GO:2000465)3.08896786
90urea metabolic process (GO:0019627)3.08132190
91peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.08075420
92lipid particle organization (GO:0034389)3.06387864
93regulation of endothelial cell differentiation (GO:0045601)3.05751936
94endothelial cell morphogenesis (GO:0001886)3.05384684
95C21-steroid hormone metabolic process (GO:0008207)3.05070947
96negative regulation of protein activation cascade (GO:2000258)3.03752488
97intracellular lipid transport (GO:0032365)3.01673890
98positive regulation of metanephros development (GO:0072216)3.00759665
99embryonic foregut morphogenesis (GO:0048617)3.00162025
100regulation of female gonad development (GO:2000194)2.98723425
101regulation of cAMP-dependent protein kinase activity (GO:2000479)2.97968551
102positive regulation of vascular permeability (GO:0043117)2.97521396
103cAMP biosynthetic process (GO:0006171)2.97102740
104protein localization to cell surface (GO:0034394)2.97073506
105oocyte development (GO:0048599)2.97018867
106regulation of meiosis I (GO:0060631)2.96947171
107coronary vasculature morphogenesis (GO:0060977)2.96858134
108acylglycerol metabolic process (GO:0006639)2.96690650
109extracellular fibril organization (GO:0043206)2.95843286
110sex differentiation (GO:0007548)2.94516610
111glucocorticoid metabolic process (GO:0008211)2.94036485
112response to follicle-stimulating hormone (GO:0032354)2.91957420
113regulation of receptor binding (GO:1900120)2.91613914
114positive regulation of glucose import (GO:0046326)2.91484924
115nitrogen cycle metabolic process (GO:0071941)2.90805638
116neutral lipid metabolic process (GO:0006638)2.90564242
117positive regulation of cholesterol transport (GO:0032376)2.90301790
118positive regulation of sterol transport (GO:0032373)2.90301790
119brown fat cell differentiation (GO:0050873)2.88776021
120triglyceride biosynthetic process (GO:0019432)2.88391359
121negative regulation of vascular permeability (GO:0043116)2.87802559
122lung vasculature development (GO:0060426)2.87614031
123vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.87457747
124valine metabolic process (GO:0006573)2.87381974
125protein heterotrimerization (GO:0070208)2.86905106
126renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.85930258
127positive regulation of endothelial cell apoptotic process (GO:2000353)2.85818392
128patterning of blood vessels (GO:0001569)2.84595458
129endothelium development (GO:0003158)2.82133061
130male sex determination (GO:0030238)2.81324205
131ethanol oxidation (GO:0006069)2.81065332
132negative regulation of DNA biosynthetic process (GO:2000279)2.80115099
133regulation of macrophage derived foam cell differentiation (GO:0010743)2.78653263
134negative regulation of smooth muscle cell migration (GO:0014912)2.78098819
135positive regulation of lipoprotein lipase activity (GO:0051006)2.77951823
136positive regulation of triglyceride lipase activity (GO:0061365)2.77951823
137positive regulation of fatty acid beta-oxidation (GO:0032000)2.77509349
138neutral lipid biosynthetic process (GO:0046460)2.75909233
139acylglycerol biosynthetic process (GO:0046463)2.75909233
140negative regulation of blood vessel endothelial cell migration (GO:0043537)2.75833584
141ovulation from ovarian follicle (GO:0001542)2.73552947
142positive regulation of triglyceride biosynthetic process (GO:0010867)2.72510013
143establishment of endothelial barrier (GO:0061028)2.72221360
144estrogen biosynthetic process (GO:0006703)2.70913729
145regulation of glomerular filtration (GO:0003093)2.70820766
146regulation of vasculogenesis (GO:2001212)2.70722994
147ethanol metabolic process (GO:0006067)2.68368838
148progesterone metabolic process (GO:0042448)2.68006540
149regulation of fatty acid beta-oxidation (GO:0031998)2.67819816
150epithelial cell-cell adhesion (GO:0090136)2.67642266
151stress fiber assembly (GO:0043149)2.66993068
152regulation of sequestering of triglyceride (GO:0010889)2.66788472
153fibroblast migration (GO:0010761)2.66019342
154synaptonemal complex assembly (GO:0007130)2.65897013
155regulation of cardioblast differentiation (GO:0051890)2.65074552
156reverse cholesterol transport (GO:0043691)2.62893886
157fibril organization (GO:0097435)2.62673605
158phagocytosis, recognition (GO:0006910)2.60856893
159lysine metabolic process (GO:0006553)2.59866996
160lysine catabolic process (GO:0006554)2.59866996
161biotin metabolic process (GO:0006768)2.58497132
162carnitine transmembrane transport (GO:1902603)2.56417012
163fatty acid beta-oxidation (GO:0006635)2.54272853
164regulation of endothelial cell chemotaxis (GO:2001026)2.54212439
165establishment of apical/basal cell polarity (GO:0035089)2.52116022
166positive regulation of lipid storage (GO:0010884)2.52082812
167plasma membrane fusion (GO:0045026)2.51450950
168branching involved in salivary gland morphogenesis (GO:0060445)2.51434153
169protein localization to endosome (GO:0036010)2.50673072
170endothelial cell migration (GO:0043542)2.50159194
171positive regulation of triglyceride metabolic process (GO:0090208)2.49084996
172carnitine transport (GO:0015879)2.47458063
173amino-acid betaine transport (GO:0015838)2.47458063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.82172197
2CLOCK_20551151_ChIP-Seq_293T_Human4.20095991
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.06523903
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.33929998
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.11489406
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.07078377
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.96258830
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.83794392
9ZNF263_19887448_ChIP-Seq_K562_Human2.82674692
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.52841342
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50024880
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.49796899
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43080502
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.41349680
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.41349680
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.41349680
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.35664276
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35590375
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.32296148
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28551363
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.97894784
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97265953
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.93807636
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.88748203
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.82338978
26GATA1_22025678_ChIP-Seq_K562_Human1.80049075
27TBX20_22080862_ChIP-Seq_HEART_Mouse1.77949113
28TBX20_22328084_ChIP-Seq_HEART_Mouse1.77949113
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74392089
30RACK7_27058665_Chip-Seq_MCF-7_Human1.69428589
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68489719
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.63053649
33* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60946248
34PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.57144142
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55427786
36* LXR_22292898_ChIP-Seq_THP-1_Human1.55399496
37* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51708929
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50926039
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49710961
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.48708961
41KDM2B_26808549_Chip-Seq_DND41_Human1.46473840
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44800747
43* KDM2B_26808549_Chip-Seq_K562_Human1.44512776
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41351613
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40065520
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39011107
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37302344
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34473725
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33950576
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.33368113
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.32863793
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32450477
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30660916
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.30278520
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30241825
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.27620905
57* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25895148
58FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.24412771
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23779460
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23212441
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22399468
62NCOR1_26117541_ChIP-Seq_K562_Human1.21942089
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21455586
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20338976
65GATA1_19941826_ChIP-Seq_K562_Human1.19233123
66ATF3_27146783_Chip-Seq_COLON_Human1.17481382
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16646171
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15885604
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15258068
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15209512
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14935174
72PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.14744769
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14354648
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12998916
75TCF7_22412390_ChIP-Seq_EML_Mouse1.12909887
76SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12677479
77* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12329708
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10905534
79* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10308016
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09913280
81* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09286718
82* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09286718
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08067422
84* CREB1_26743006_Chip-Seq_LNCaP_Human1.06497882
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05634220
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05288927
87CTCF_27219007_Chip-Seq_Bcells_Human1.04910180
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04547987
89* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03878106
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03540080
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00707007
92RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00560825
93UBF1/2_26484160_Chip-Seq_HMECs_Human0.98358831
94SA1_22415368_ChIP-Seq_MEFs_Mouse0.97563930
95GATA4_25053715_ChIP-Seq_YYC3_Human0.97467025
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97310313
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95170371
98ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94604647
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93541391
100TP53_22127205_ChIP-Seq_IMR90_Human0.92435036
101ISL1_27105846_Chip-Seq_CPCs_Mouse0.91559983
102TET1_21490601_ChIP-Seq_MESCs_Mouse0.91379830
103CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91214390
104* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90786357
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90738667
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89974264
107SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89517961
108* ERG_21242973_ChIP-ChIP_JURKAT_Human0.89483962
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88377595
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86642024
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.86587918
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86548590
113VDR_21846776_ChIP-Seq_THP-1_Human0.86281462
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86038208
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86033453
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85487193
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.84720538
118* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84247141
119P68_20966046_ChIP-Seq_HELA_Human0.83907430
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82914463
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82481106
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.82429008
123GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82128726
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.81737913
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81489148
126P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81084936
127* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81076230
128SMC4_20622854_ChIP-Seq_HELA_Human0.80729208
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80331898
130TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80223187
131* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80104924
132TP53_20018659_ChIP-ChIP_R1E_Mouse0.78934643
133AHR_22903824_ChIP-Seq_MCF-7_Human0.78663164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.11493276
2MP0004272_abnormal_basement_membrane4.16702802
3MP0008995_early_reproductive_senescence4.05051348
4MP0001879_abnormal_lymphatic_vessel3.34718873
5MP0005167_abnormal_blood-brain_barrier3.02198017
6MP0003705_abnormal_hypodermis_morpholog2.47449347
7MP0005670_abnormal_white_adipose2.40970140
8MP0001958_emphysema2.35402996
9MP0009115_abnormal_fat_cell2.35071865
10MP0001661_extended_life_span2.27013898
11MP0005377_hearing/vestibular/ear_phenot2.11318498
12MP0003878_abnormal_ear_physiology2.11318498
13MP0008438_abnormal_cutaneous_collagen2.06310983
14MP0003191_abnormal_cellular_cholesterol2.03276600
15MP0002139_abnormal_hepatobiliary_system1.97380104
16MP0005623_abnormal_meninges_morphology1.88352637
17MP0000751_myopathy1.84689446
18MP0003195_calcinosis1.84272843
19MP0003959_abnormal_lean_body1.83113276
20MP0002970_abnormal_white_adipose1.82859071
21* MP0004084_abnormal_cardiac_muscle1.80734367
22MP0005334_abnormal_fat_pad1.80494110
23MP0004185_abnormal_adipocyte_glucose1.77586810
24MP0005666_abnormal_adipose_tissue1.74539663
25MP0004130_abnormal_muscle_cell1.72194397
26MP0003566_abnormal_cell_adhesion1.69615021
27MP0004782_abnormal_surfactant_physiolog1.67477454
28MP0005360_urolithiasis1.61887688
29MP0000639_abnormal_adrenal_gland1.60690231
30MP0010329_abnormal_lipoprotein_level1.54431906
31MP0000537_abnormal_urethra_morphology1.50210551
32MP0003828_pulmonary_edema1.49927652
33MP0003045_fibrosis1.47143215
34MP0009278_abnormal_bone_marrow1.43190860
35MP0002138_abnormal_hepatobiliary_system1.43175861
36MP0001756_abnormal_urination1.37602532
37MP0005375_adipose_tissue_phenotype1.36320034
38MP0000749_muscle_degeneration1.36064904
39MP0002108_abnormal_muscle_morphology1.35391770
40* MP0006138_congestive_heart_failure1.32569194
41MP0009643_abnormal_urine_homeostasis1.30231268
42MP0000759_abnormal_skeletal_muscle1.29063860
43MP0003300_gastrointestinal_ulcer1.29041791
44* MP0004036_abnormal_muscle_relaxation1.28690590
45MP0000013_abnormal_adipose_tissue1.28606772
46MP0005365_abnormal_bile_salt1.27933550
47MP0005058_abnormal_lysosome_morphology1.27801182
48MP0005535_abnormal_body_temperature1.21900625
49MP0000767_abnormal_smooth_muscle1.21078709
50MP0005275_abnormal_skin_tensile1.21039409
51MP0002168_other_aberrant_phenotype1.20971366
52MP0005332_abnormal_amino_acid1.20712227
53* MP0005595_abnormal_vascular_smooth1.20567806
54MP0002877_abnormal_melanocyte_morpholog1.18349977
55MP0002128_abnormal_blood_circulation1.18175803
56MP0008875_abnormal_xenobiotic_pharmacok1.17624694
57MP0008004_abnormal_stomach_pH1.15714196
58MP0005409_darkened_coat_color1.15585066
59MP0003115_abnormal_respiratory_system1.14941359
60MP0005330_cardiomyopathy1.13256698
61MP0001727_abnormal_embryo_implantation1.12798798
62MP0002876_abnormal_thyroid_physiology1.12400426
63MP0005165_increased_susceptibility_to1.11673127
64* MP0010630_abnormal_cardiac_muscle1.11550584
65MP0000003_abnormal_adipose_tissue1.11099388
66MP0008961_abnormal_basal_metabolism1.11007797
67MP0003724_increased_susceptibility_to1.10677374
68MP0003868_abnormal_feces_composition1.10080476
69MP0003186_abnormal_redox_activity1.09892737
70* MP0001544_abnormal_cardiovascular_syste1.09550000
71* MP0005385_cardiovascular_system_phenoty1.09550000
72MP0008877_abnormal_DNA_methylation1.05609983
73* MP0000343_altered_response_to1.04156153
74MP0008775_abnormal_heart_ventricle1.03884740
75MP0001849_ear_inflammation1.03269162
76MP0003091_abnormal_cell_migration1.02129726
77MP0002933_joint_inflammation1.01725153
78MP0003786_premature_aging1.01360246
79MP0009384_cardiac_valve_regurgitation1.01153330
80MP0005085_abnormal_gallbladder_physiolo1.00712573
81* MP0004087_abnormal_muscle_fiber1.00601430
82MP0003279_aneurysm1.00074504
83MP0003252_abnormal_bile_duct0.98360621
84MP0000609_abnormal_liver_physiology0.98186046
85MP0002118_abnormal_lipid_homeostasis0.97675431
86* MP0005319_abnormal_enzyme/_coenzyme0.96754149
87MP0000747_muscle_weakness0.95941071
88MP0005448_abnormal_energy_balance0.95841304
89* MP0000230_abnormal_systemic_arterial0.94511175
90MP0002837_dystrophic_cardiac_calcinosis0.94414384
91MP0002925_abnormal_cardiovascular_devel0.93726565
92MP0005076_abnormal_cell_differentiation0.93650164
93MP0003950_abnormal_plasma_membrane0.93374027
94* MP0001614_abnormal_blood_vessel0.91486829
95MP0000750_abnormal_muscle_regeneration0.90699283
96* MP0005647_abnormal_sex_gland0.90571100
97MP0002136_abnormal_kidney_physiology0.89699187
98MP0004215_abnormal_myocardial_fiber0.89132789
99MP0003948_abnormal_gas_homeostasis0.87461046
100MP0005452_abnormal_adipose_tissue0.87323960
101MP0003690_abnormal_glial_cell0.86615062
102MP0010030_abnormal_orbit_morphology0.85222478
103MP0000249_abnormal_blood_vessel0.84142681
104MP0003119_abnormal_digestive_system0.84116585
105MP0003011_delayed_dark_adaptation0.83415618
106MP0001915_intracranial_hemorrhage0.83033874
107* MP0000266_abnormal_heart_morphology0.81745013
108MP0003075_altered_response_to0.80829329
109MP0009780_abnormal_chondrocyte_physiolo0.80647528
110MP0003567_abnormal_fetal_cardiomyocyte0.80483198
111MP0002135_abnormal_kidney_morphology0.80130929
112MP0003942_abnormal_urinary_system0.79556264
113MP0002127_abnormal_cardiovascular_syste0.79503637
114MP0003283_abnormal_digestive_organ0.78033101
115MP0002971_abnormal_brown_adipose0.78017581
116MP0002909_abnormal_adrenal_gland0.77312469
117* MP0002295_abnormal_pulmonary_circulatio0.77283481
118MP0000534_abnormal_ureter_morphology0.76485301
119MP0005369_muscle_phenotype0.76022650
120MP0009840_abnormal_foam_cell0.75355182
121MP0005584_abnormal_enzyme/coenzyme_acti0.75318694
122MP0004233_abnormal_muscle_weight0.75280152
123MP0002060_abnormal_skin_morphology0.74474832
124MP0002254_reproductive_system_inflammat0.74235075
125MP0006054_spinal_hemorrhage0.73871571
126MP0000733_abnormal_muscle_development0.73461265
127MP0005620_abnormal_muscle_contractility0.73116810
128MP0002269_muscular_atrophy0.72921934
129MP0004484_altered_response_of0.72445923
130MP0002972_abnormal_cardiac_muscle0.72365118
131MP0002133_abnormal_respiratory_system0.71394394
132MP0005388_respiratory_system_phenotype0.71394394
133MP0002078_abnormal_glucose_homeostasis0.71318501
134MP0005503_abnormal_tendon_morphology0.71164217
135MP0004883_abnormal_blood_vessel0.70901599
136MP0002332_abnormal_exercise_endurance0.69491053
137MP0002086_abnormal_extraembryonic_tissu0.69468846
138MP0002106_abnormal_muscle_physiology0.69392160
139MP0002796_impaired_skin_barrier0.67871389
140MP0005164_abnormal_response_to0.65914233
141MP0005023_abnormal_wound_healing0.64405772
142MP0003303_peritoneal_inflammation0.63705163
143MP0006036_abnormal_mitochondrial_physio0.63204086
144MP0005451_abnormal_body_composition0.63069310
145MP0002998_abnormal_bone_remodeling0.61575388
146MP0005508_abnormal_skeleton_morphology0.60890301

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)5.69184770
2Gonadal dysgenesis (HP:0000133)5.24143698
3Oligomenorrhea (HP:0000876)4.75043658
4Male infertility (HP:0003251)4.47178957
5Polycythemia (HP:0001901)4.39520455
6Lymphangioma (HP:0100764)4.10022268
7Hypertriglyceridemia (HP:0002155)4.03128512
8Systemic lupus erythematosus (HP:0002725)4.02961933
9Renal salt wasting (HP:0000127)4.01493474
10Cerebral aneurysm (HP:0004944)3.84412898
11Focal segmental glomerulosclerosis (HP:0000097)3.84241740
12Testicular neoplasm (HP:0010788)3.81861881
13Deep venous thrombosis (HP:0002625)3.53653630
14Hematochezia (HP:0002573)3.49855685
15Rectal prolapse (HP:0002035)3.44996721
16Ankle contracture (HP:0006466)3.39482365
17Hypercholesterolemia (HP:0003124)3.36892305
18Myocardial infarction (HP:0001658)3.33245681
19Abnormality of complement system (HP:0005339)3.33079485
20Gonadotropin excess (HP:0000837)3.31227938
21Glomerulosclerosis (HP:0000096)3.27392903
22Metaphyseal cupping (HP:0003021)3.27145878
23Sex reversal (HP:0012245)3.20368163
24Abnormal sex determination (HP:0012244)3.20368163
25Nephritis (HP:0000123)3.17856554
26Facial diplegia (HP:0001349)3.14785004
27Increased connective tissue (HP:0009025)3.09167599
28Premature rupture of membranes (HP:0001788)2.97145061
29Vertebral compression fractures (HP:0002953)2.94017291
30Broad metatarsal (HP:0001783)2.92613221
31Hyporeflexia of lower limbs (HP:0002600)2.92455455
32Hand muscle atrophy (HP:0009130)2.90645289
33Esophageal varix (HP:0002040)2.89483860
34Visceral angiomatosis (HP:0100761)2.84699694
35Azoospermia (HP:0000027)2.84048845
36Abnormality of the nasal mucosa (HP:0000433)2.78724949
37Insulin resistance (HP:0000855)2.77606712
38Asymmetric septal hypertrophy (HP:0001670)2.77257859
39Distal lower limb muscle weakness (HP:0009053)2.73097363
40Axonal loss (HP:0003447)2.71760377
41Aneurysm (HP:0002617)2.70659893
42Protrusio acetabuli (HP:0003179)2.66291306
43Abnormality of the periventricular white matter (HP:0002518)2.64810986
44Hemangiomatosis (HP:0007461)2.63959615
45Distal lower limb amyotrophy (HP:0008944)2.63704839
46Spontaneous hematomas (HP:0007420)2.62377177
47Male pseudohermaphroditism (HP:0000037)2.61799890
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.59767709
49Osteolytic defects of the hand bones (HP:0009699)2.59767709
50Difficulty running (HP:0009046)2.59111145
51Hyperkalemia (HP:0002153)2.55935185
52Muscle fiber splitting (HP:0003555)2.55620007
53Bulbar palsy (HP:0001283)2.54004107
54Aortic aneurysm (HP:0004942)2.49286825
55Upper limb amyotrophy (HP:0009129)2.49236365
56Distal upper limb amyotrophy (HP:0007149)2.49236365
57Neck muscle weakness (HP:0000467)2.48968935
58Stage 5 chronic kidney disease (HP:0003774)2.47666563
59Ectopia lentis (HP:0001083)2.46131212
60Muscle fibrillation (HP:0010546)2.46105664
61Colitis (HP:0002583)2.42828737
62Vacuolated lymphocytes (HP:0001922)2.41997698
63Germ cell neoplasia (HP:0100728)2.41558746
64Lipoatrophy (HP:0100578)2.40842775
65Interstitial pulmonary disease (HP:0006530)2.40353592
66Enlarged penis (HP:0000040)2.39990345
67Hyperglycinuria (HP:0003108)2.39955398
68Myotonia (HP:0002486)2.31317054
69Wormian bones (HP:0002645)2.30368882
70Increased variability in muscle fiber diameter (HP:0003557)2.30135073
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.26890548
72Hemorrhage of the eye (HP:0011885)2.26584410
73Hypercortisolism (HP:0001578)2.26098167
74Type 1 muscle fiber predominance (HP:0003803)2.24097540
75Stridor (HP:0010307)2.23303398
76Rhabdomyolysis (HP:0003201)2.22280230
77Centrally nucleated skeletal muscle fibers (HP:0003687)2.21512809
78Skin nodule (HP:0200036)2.21266706
79Abnormality of renin-angiotensin system (HP:0000847)2.19203032
80Mitral valve prolapse (HP:0001634)2.18956125
81Reduced subcutaneous adipose tissue (HP:0003758)2.18555466
82Nausea (HP:0002018)2.17498742
83Wrist flexion contracture (HP:0001239)2.14865425
84Growth hormone excess (HP:0000845)2.13777853
85Dilatation of the ascending aorta (HP:0005111)2.13079623
86Polygenic inheritance (HP:0010982)2.12680826
87Abnormal albumin level (HP:0012116)2.09707269
88Hypoalbuminemia (HP:0003073)2.09707269
89Conjunctival telangiectasia (HP:0000524)2.09037260
90Complement deficiency (HP:0004431)2.08725107
91Increased circulating renin level (HP:0000848)2.08153355
92Hyperaldosteronism (HP:0000859)2.07466662
93Cerebral hemorrhage (HP:0001342)2.07171678
94Hyperlipoproteinemia (HP:0010980)2.04386498
95Striae distensae (HP:0001065)2.03853707
96Abnormality of the lower motor neuron (HP:0002366)2.03584658
97Foot dorsiflexor weakness (HP:0009027)2.01020643
98Exercise-induced myalgia (HP:0003738)2.00709927
99Amyloidosis (HP:0011034)2.00613435
100Bladder diverticulum (HP:0000015)2.00386218
101Atrioventricular block (HP:0001678)2.00187940
102Pulmonary hypertension (HP:0002092)1.99403328
103Nuclear cataract (HP:0100018)1.98980717
104Hypoplasia of the uterus (HP:0000013)1.97730157
105Difficulty climbing stairs (HP:0003551)1.96755784
106Abnormality of skeletal muscle fiber size (HP:0012084)1.96439144
107Joint hemorrhage (HP:0005261)1.96126313
108Hypoglycemic coma (HP:0001325)1.95684827
109Shawl scrotum (HP:0000049)1.95540090
110Round ear (HP:0100830)1.95352567
111Diaphragmatic weakness (HP:0009113)1.93605139
112Insulin-resistant diabetes mellitus (HP:0000831)1.93549826
113Cervical subluxation (HP:0003308)1.93171183
114Bone cyst (HP:0012062)1.93014187
115Skull defect (HP:0001362)1.92815886
116Vascular tortuosity (HP:0004948)1.92257590
117Persistence of primary teeth (HP:0006335)1.91745283
118Sudden death (HP:0001699)1.91528285
119Tubulointerstitial fibrosis (HP:0005576)1.91020910
120Pulmonary artery stenosis (HP:0004415)1.90068933
121Scapular winging (HP:0003691)1.90057987
122Myoglobinuria (HP:0002913)1.90043142
123EMG: myopathic abnormalities (HP:0003458)1.89541172
124Segmental peripheral demyelination/remyelination (HP:0003481)1.88996938
125Acanthosis nigricans (HP:0000956)1.88951552
126Steatorrhea (HP:0002570)1.88056815
127Aortic dissection (HP:0002647)1.87664699
128Hyperpituitarism (HP:0010514)1.87551142
129Abnormality of the vasculature of the conjunctiva (HP:0008054)1.86774191
130Abnormal spermatogenesis (HP:0008669)1.86259352
131Hypoplastic left heart (HP:0004383)1.85572362
132Joint stiffness (HP:0001387)1.85380565
133Stroke (HP:0001297)1.85316075
134Abnormality of serine family amino acid metabolism (HP:0010894)1.85302583
135Abnormality of glycine metabolism (HP:0010895)1.85302583
136Hypoplasia of the iris (HP:0007676)1.85229815
137Right ventricular cardiomyopathy (HP:0011663)1.85080237
138Impaired pain sensation (HP:0007328)1.84366397
139Abnormality of pain sensation (HP:0010832)1.84366397
140Back pain (HP:0003418)1.84302456
141Hydroxyprolinuria (HP:0003080)1.84112532
142Abnormality of proline metabolism (HP:0010907)1.84112532
143Spinal rigidity (HP:0003306)1.83696058
144Glomerulonephritis (HP:0000099)1.83271382
145Abnormality of the foot musculature (HP:0001436)1.82282011
146Pigmentary retinal degeneration (HP:0001146)1.82009188
147Gout (HP:0001997)1.80376171
148Hyperactive renin-angiotensin system (HP:0000841)1.78167784
149Hyperammonemia (HP:0001987)1.78020378
150Lower limb amyotrophy (HP:0007210)1.77722707
151Venous abnormality (HP:0002624)1.77421326
152Nonimmune hydrops fetalis (HP:0001790)1.77375384
153Cavernous hemangioma (HP:0001048)1.77003984
154Hematuria (HP:0000790)1.76571269
155Bronchomalacia (HP:0002780)1.76519286
156Mildly elevated creatine phosphokinase (HP:0008180)1.73618896
157Neonatal onset (HP:0003623)1.73410160
158Increased muscle lipid content (HP:0009058)1.73180789
159Adactyly (HP:0009776)1.72845364
160Tongue fasciculations (HP:0001308)1.72650996
161Shallow orbits (HP:0000586)1.71428302
162Secondary amenorrhea (HP:0000869)1.71145035
163Ventricular tachycardia (HP:0004756)1.71116725
164Abnormality of fatty-acid metabolism (HP:0004359)1.71061422
165Hypoalphalipoproteinemia (HP:0003233)1.70850588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.50358101
2TRIB34.24004506
3KDR3.45517603
4RIPK13.04808816
5ERN12.76598075
6TGFBR22.73827262
7CDK122.39098178
8TYRO32.24724403
9MYLK2.16933467
10EPHB22.15590107
11PTK62.07752502
12PAK42.02892129
13WNK41.96025861
14PKN21.95902718
15PDGFRA1.91554814
16LATS11.91304580
17EPHB11.89613848
18ICK1.86026507
19BCKDK1.80880438
20MAP3K61.72284259
21TTN1.67872653
22FGFR41.66233311
23SIK11.60945371
24PDK31.55762990
25PDK41.55762990
26TGFBR11.54959101
27CAMK1D1.52124859
28PRKD31.51312145
29PTK2B1.44237068
30PRPF4B1.33950502
31MAP3K131.32976709
32TRPM71.32513170
33FER1.32312088
34TESK11.28607645
35PDK21.25737180
36AKT31.22567679
37MAPK41.17370958
38CAMK1G1.14452828
39EPHA31.12518961
40LMTK21.11875934
41WNK31.10846531
42FES1.10604742
43FGFR21.06049960
44CAMK11.04670028
45RPS6KA21.03860258
46MTOR1.03606119
47PTK21.00609618
48MST1R1.00136890
49OBSCN0.96439786
50ABL20.95922644
51ARAF0.95626417
52LRRK20.93521188
53MAP2K30.92810683
54MET0.92185884
55DMPK0.91661623
56CDK70.90632112
57LATS20.88671799
58MAPK70.84828415
59MOS0.81937296
60GSK3A0.78273307
61MAP3K30.77321341
62STK30.76335932
63STK38L0.75056909
64BMX0.73711836
65SMG10.73553159
66PAK20.72755564
67MAP3K100.72234710
68NLK0.71639054
69PDGFRB0.70659360
70DAPK20.69759412
71PRKD10.67489357
72MAPKAPK50.67104997
73MARK20.65888299
74WNK10.65768557
75CDK90.64720152
76EPHA20.62926360
77CSK0.62455191
78MAP2K20.62453840
79PRKAA20.60873429
80MAPK150.59787375
81FGFR10.58416643
82FGFR30.58290786
83GRK10.57276260
84CDK40.57070703
85JAK30.56963244
86AKT20.56795198
87STK390.56245250
88DAPK30.55791271
89BRD40.54767555
90STK240.51970911
91PHKG20.51653858
92PHKG10.51653858
93RPS6KC10.51326907
94RPS6KL10.51326907
95MAP3K70.51066754
96ILK0.51024522
97CDK60.49773852
98RET0.49078560
99MAPKAPK30.46463281
100GRK50.44393025
101BLK0.43948905
102DDR20.43866226
103PRKD20.43497026
104ROCK10.43137642
105EGFR0.42320567
106PRKCH0.40211119
107PDPK10.40117679
108RPS6KB20.40076177
109CDC42BPA0.39583369
110NEK10.39041295
111TYK20.37782874
112SGK4940.37145300
113SGK2230.37145300
114FLT30.36828360
115MAP2K10.36404472
116PRKAA10.35759684
117MAPK30.35652146
118PDK10.35604784
119* PRKACG0.35502511
120NME20.35382399
121NEK90.33411830
122MAPK120.33348131
123MAP3K110.32750525
124JAK20.32391245
125RPS6KA60.32179638
126PRKG20.32098568
127EEF2K0.31771275
128CHUK0.31430164
129YES10.31022253
130SGK20.30248063
131PAK10.29984941
132PRKG10.29056611
133NEK20.28964468
134IGF1R0.28565340
135PAK30.27942705
136STK100.27600487
137JAK10.27438326
138SGK30.27359564
139ZAP700.26568378
140MAP3K10.26555145

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid metabolism_Homo sapiens_hsa012123.17911447
2Fatty acid degradation_Homo sapiens_hsa000713.11382270
3Fatty acid biosynthesis_Homo sapiens_hsa000612.85748381
4PPAR signaling pathway_Homo sapiens_hsa033202.69306894
5Propanoate metabolism_Homo sapiens_hsa006402.65180955
6ECM-receptor interaction_Homo sapiens_hsa045122.59879681
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53467560
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.39253063
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.36323978
10Complement and coagulation cascades_Homo sapiens_hsa046102.01677141
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96660943
12Nitrogen metabolism_Homo sapiens_hsa009101.87638674
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.86344125
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82093696
15Pyruvate metabolism_Homo sapiens_hsa006201.76356022
16Tryptophan metabolism_Homo sapiens_hsa003801.75748697
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.75243868
18Focal adhesion_Homo sapiens_hsa045101.73460846
19Lysine degradation_Homo sapiens_hsa003101.69149988
20Ovarian steroidogenesis_Homo sapiens_hsa049131.64919428
21Small cell lung cancer_Homo sapiens_hsa052221.64067333
22Arginine biosynthesis_Homo sapiens_hsa002201.56522214
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55349924
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52270148
25Amoebiasis_Homo sapiens_hsa051461.52115591
26Bile secretion_Homo sapiens_hsa049761.49290200
27Protein digestion and absorption_Homo sapiens_hsa049741.47749014
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.47407085
29Vitamin digestion and absorption_Homo sapiens_hsa049771.45992951
30Other glycan degradation_Homo sapiens_hsa005111.38841103
31Carbon metabolism_Homo sapiens_hsa012001.35535546
32Fatty acid elongation_Homo sapiens_hsa000621.32894000
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.30816722
34Insulin resistance_Homo sapiens_hsa049311.30646836
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27848851
36Fat digestion and absorption_Homo sapiens_hsa049751.26195003
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21088236
38Dorso-ventral axis formation_Homo sapiens_hsa043201.15965175
39beta-Alanine metabolism_Homo sapiens_hsa004101.15157870
40Adherens junction_Homo sapiens_hsa045201.13503615
41Glycerolipid metabolism_Homo sapiens_hsa005611.10814709
42* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09142687
43Butanoate metabolism_Homo sapiens_hsa006501.05529436
44Caffeine metabolism_Homo sapiens_hsa002321.05410562
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98394274
46Sulfur relay system_Homo sapiens_hsa041220.96777149
47Notch signaling pathway_Homo sapiens_hsa043300.96239522
48Pentose phosphate pathway_Homo sapiens_hsa000300.95236108
49Tight junction_Homo sapiens_hsa045300.92560809
50Selenocompound metabolism_Homo sapiens_hsa004500.92504288
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92079459
52Dilated cardiomyopathy_Homo sapiens_hsa054140.91702882
53* Vascular smooth muscle contraction_Homo sapiens_hsa042700.88733864
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87837877
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86869196
56AMPK signaling pathway_Homo sapiens_hsa041520.84652978
57TGF-beta signaling pathway_Homo sapiens_hsa043500.84005705
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82745556
59Malaria_Homo sapiens_hsa051440.81833419
60Peroxisome_Homo sapiens_hsa041460.80951411
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79362064
62* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77404720
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.77035055
64Proteoglycans in cancer_Homo sapiens_hsa052050.76636104
65Tyrosine metabolism_Homo sapiens_hsa003500.76622943
66Renin-angiotensin system_Homo sapiens_hsa046140.75095697
67Lysosome_Homo sapiens_hsa041420.74557487
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.72055482
69Viral myocarditis_Homo sapiens_hsa054160.71637407
70Biosynthesis of amino acids_Homo sapiens_hsa012300.71140774
71Chemical carcinogenesis_Homo sapiens_hsa052040.71075832
72Hippo signaling pathway_Homo sapiens_hsa043900.68727991
73Hematopoietic cell lineage_Homo sapiens_hsa046400.68093431
74ABC transporters_Homo sapiens_hsa020100.67021691
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66355664
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64679941
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63367350
78Galactose metabolism_Homo sapiens_hsa000520.60853906
79Toxoplasmosis_Homo sapiens_hsa051450.60762607
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.60383709
81Pertussis_Homo sapiens_hsa051330.60127698
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60110411
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59456783
84Staphylococcus aureus infection_Homo sapiens_hsa051500.58862008
85* Renin secretion_Homo sapiens_hsa049240.58484904
86Retinol metabolism_Homo sapiens_hsa008300.58085441
87Insulin signaling pathway_Homo sapiens_hsa049100.57389894
88VEGF signaling pathway_Homo sapiens_hsa043700.57355556
89Vitamin B6 metabolism_Homo sapiens_hsa007500.56536760
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56038235
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55680674
92Prion diseases_Homo sapiens_hsa050200.55596986
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52987922
94Hedgehog signaling pathway_Homo sapiens_hsa043400.52276652
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.51453224
96Glucagon signaling pathway_Homo sapiens_hsa049220.50432596
97Fructose and mannose metabolism_Homo sapiens_hsa000510.49908894
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49593301
99Axon guidance_Homo sapiens_hsa043600.49275480
100Mineral absorption_Homo sapiens_hsa049780.49211672
101mTOR signaling pathway_Homo sapiens_hsa041500.48313522
102Starch and sucrose metabolism_Homo sapiens_hsa005000.47889399
103Histidine metabolism_Homo sapiens_hsa003400.47707385
104Pathways in cancer_Homo sapiens_hsa052000.47411468
105Steroid biosynthesis_Homo sapiens_hsa001000.46197816
106Phenylalanine metabolism_Homo sapiens_hsa003600.45803935
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44820185
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.44265221
109Arginine and proline metabolism_Homo sapiens_hsa003300.44263454
110Thyroid cancer_Homo sapiens_hsa052160.43574741
111Acute myeloid leukemia_Homo sapiens_hsa052210.43504731
112Rap1 signaling pathway_Homo sapiens_hsa040150.43406470
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.43241798
114Basal cell carcinoma_Homo sapiens_hsa052170.42367581
115Thyroid hormone synthesis_Homo sapiens_hsa049180.41953799
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38501321
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36518596
118Phagosome_Homo sapiens_hsa041450.35404648
119Renal cell carcinoma_Homo sapiens_hsa052110.33447515
120Glutathione metabolism_Homo sapiens_hsa004800.31236423
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30616880
122Platelet activation_Homo sapiens_hsa046110.30277547
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30163008
124* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29756906
125HIF-1 signaling pathway_Homo sapiens_hsa040660.29578856
126Gap junction_Homo sapiens_hsa045400.26985084
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26078421
128Circadian rhythm_Homo sapiens_hsa047100.25750687
129GnRH signaling pathway_Homo sapiens_hsa049120.25629433

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