NPR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)4.66944204
2L-phenylalanine catabolic process (GO:0006559)4.16190100
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.16190100
4collagen fibril organization (GO:0030199)4.06771164
5L-phenylalanine metabolic process (GO:0006558)3.96829926
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.96829926
7alpha-linolenic acid metabolic process (GO:0036109)3.79903902
8bone trabecula formation (GO:0060346)3.70206575
9aromatic amino acid family catabolic process (GO:0009074)3.63369780
10skin morphogenesis (GO:0043589)3.62745355
11extracellular matrix assembly (GO:0085029)3.60587184
12negative regulation of fibrinolysis (GO:0051918)3.57631933
13chondrocyte proliferation (GO:0035988)3.56062172
14lysine catabolic process (GO:0006554)3.50784186
15lysine metabolic process (GO:0006553)3.50784186
16cell migration involved in heart development (GO:0060973)3.49522454
17positive regulation of fatty acid beta-oxidation (GO:0032000)3.46364513
18endodermal cell differentiation (GO:0035987)3.45092807
19kynurenine metabolic process (GO:0070189)3.44363194
20bile acid biosynthetic process (GO:0006699)3.42298954
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.40661541
22kidney mesenchyme development (GO:0072074)3.39046519
23glyoxylate metabolic process (GO:0046487)3.34355641
24metanephric mesenchyme development (GO:0072075)3.33413242
25complement activation, alternative pathway (GO:0006957)3.30324484
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.29721982
27regulation of fibrinolysis (GO:0051917)3.26920211
28regulation of protein activation cascade (GO:2000257)3.26510537
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23938684
30protein carboxylation (GO:0018214)3.22270178
31peptidyl-glutamic acid carboxylation (GO:0017187)3.22270178
32dicarboxylic acid biosynthetic process (GO:0043650)3.21216235
33indole-containing compound catabolic process (GO:0042436)3.18373183
34indolalkylamine catabolic process (GO:0046218)3.18373183
35tryptophan catabolic process (GO:0006569)3.18373183
36regulation of complement activation (GO:0030449)3.15117437
37fatty acid transmembrane transport (GO:1902001)3.13830584
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.10328565
39positive regulation of fatty acid oxidation (GO:0046321)3.09496537
40negative regulation of digestive system process (GO:0060457)3.08450962
412-oxoglutarate metabolic process (GO:0006103)3.06941402
42sulfur amino acid catabolic process (GO:0000098)3.04303487
43synaptic vesicle docking involved in exocytosis (GO:0016081)3.03656954
44extracellular fibril organization (GO:0043206)3.02485897
45cellular ketone body metabolic process (GO:0046950)3.02120786
46trabecula formation (GO:0060343)3.01724236
47type B pancreatic cell proliferation (GO:0044342)2.99858887
48regulation of fatty acid beta-oxidation (GO:0031998)2.99659780
49urea cycle (GO:0000050)2.99293231
50urea metabolic process (GO:0019627)2.99293231
51protein retention in ER lumen (GO:0006621)2.97817528
52carnitine shuttle (GO:0006853)2.96284390
53tryptophan metabolic process (GO:0006568)2.93754019
54high-density lipoprotein particle remodeling (GO:0034375)2.92466653
55peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.92013818
56amino-acid betaine metabolic process (GO:0006577)2.91307857
57epoxygenase P450 pathway (GO:0019373)2.91243069
58regulation of cholesterol homeostasis (GO:2000188)2.89947290
59plasma membrane repair (GO:0001778)2.89395603
60glutamate metabolic process (GO:0006536)2.89316636
61sequestering of extracellular ligand from receptor (GO:0035581)2.88153702
62basement membrane organization (GO:0071711)2.86629681
63heart trabecula formation (GO:0060347)2.85772022
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.84738087
65coenzyme catabolic process (GO:0009109)2.84176807
66cysteine metabolic process (GO:0006534)2.83794438
67homocysteine metabolic process (GO:0050667)2.83194912
68bile acid metabolic process (GO:0008206)2.82382611
69neuron projection extension involved in neuron projection guidance (GO:1902284)2.81024656
70axon extension involved in axon guidance (GO:0048846)2.81024656
71regulation of triglyceride catabolic process (GO:0010896)2.80325082
72triglyceride homeostasis (GO:0070328)2.78803669
73acylglycerol homeostasis (GO:0055090)2.78803669
74positive regulation of lipid catabolic process (GO:0050996)2.77676594
75negative regulation of protein activation cascade (GO:2000258)2.76719772
76regulation of plasminogen activation (GO:0010755)2.75888907
77regulation of fatty acid oxidation (GO:0046320)2.75836646
78endocardial cushion development (GO:0003197)2.75537290
79fatty acid beta-oxidation (GO:0006635)2.75298250
80collagen metabolic process (GO:0032963)2.73641769
81mesenchymal-epithelial cell signaling (GO:0060638)2.73081799
82acetyl-CoA metabolic process (GO:0006084)2.71967408
83nitrogen cycle metabolic process (GO:0071941)2.71577284
84barbed-end actin filament capping (GO:0051016)2.70401120
85paraxial mesoderm development (GO:0048339)2.68997492
86cellular modified amino acid catabolic process (GO:0042219)2.68426203
87aspartate family amino acid catabolic process (GO:0009068)2.68187519
88alpha-amino acid catabolic process (GO:1901606)2.67774318
89short-chain fatty acid metabolic process (GO:0046459)2.66751510
90establishment of apical/basal cell polarity (GO:0035089)2.65659557
91negative regulation of smooth muscle cell migration (GO:0014912)2.65456420
92Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.65151341
93venous blood vessel morphogenesis (GO:0048845)2.64015955
94negative regulation of chondrocyte differentiation (GO:0032331)2.63833970
95fatty acid oxidation (GO:0019395)2.60728700
96axon extension (GO:0048675)2.60455870
97multicellular organismal macromolecule metabolic process (GO:0044259)2.58775494
98tyrosine metabolic process (GO:0006570)2.58742595
99ketone body metabolic process (GO:1902224)2.58506084
100cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.58276561
101adhesion of symbiont to host cell (GO:0044650)2.58064283
102virion attachment to host cell (GO:0019062)2.58064283
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.57736417
104reverse cholesterol transport (GO:0043691)2.57693217
105monocarboxylic acid catabolic process (GO:0072329)2.56689764
106lipid oxidation (GO:0034440)2.56688468
107dermatan sulfate metabolic process (GO:0030205)2.56659410
108dermatan sulfate biosynthetic process (GO:0030208)2.56636685
109fatty acid catabolic process (GO:0009062)2.56501582
110regulation of establishment of planar polarity (GO:0090175)2.56154072
111collagen catabolic process (GO:0030574)2.55180868
112negative regulation of complement activation (GO:0045916)2.53590683
113cellular amino acid catabolic process (GO:0009063)2.53426456
114positive regulation of smoothened signaling pathway (GO:0045880)2.53150072
115plasma lipoprotein particle clearance (GO:0034381)2.52573250
116cell adhesion mediated by integrin (GO:0033627)2.52299716
117fibril organization (GO:0097435)2.49834416
118phospholipid homeostasis (GO:0055091)2.49013512
119cochlea morphogenesis (GO:0090103)2.48647697
120aromatic amino acid family metabolic process (GO:0009072)2.48352708
121vascular endothelial growth factor signaling pathway (GO:0038084)2.47879651
122endothelial cell morphogenesis (GO:0001886)2.46686878
123negative regulation of osteoblast proliferation (GO:0033689)2.45862259
124serine family amino acid catabolic process (GO:0009071)2.43991704
125plasma lipoprotein particle remodeling (GO:0034369)2.43436580
126protein-lipid complex remodeling (GO:0034368)2.43436580
127macromolecular complex remodeling (GO:0034367)2.43436580
128regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.42610606
129ethanol oxidation (GO:0006069)2.42319635
130adhesion of symbiont to host (GO:0044406)2.42284797
131multicellular organismal metabolic process (GO:0044236)2.42268354
132positive regulation of fatty acid metabolic process (GO:0045923)2.41686644
133negative regulation of lipase activity (GO:0060192)2.41372682
134positive regulation of endothelial cell apoptotic process (GO:2000353)2.41318389
135cardiac myofibril assembly (GO:0055003)2.40955411
136carnitine metabolic process (GO:0009437)2.40948451
137camera-type eye morphogenesis (GO:0048593)2.40743383
138cellular glucuronidation (GO:0052695)2.40202796
139neuron projection extension (GO:1990138)2.39083597
140glomerular basement membrane development (GO:0032836)2.38594656
141drug catabolic process (GO:0042737)2.38495024
142midgut development (GO:0007494)2.37757054
143cell communication by electrical coupling (GO:0010644)2.37353472
144stress fiber assembly (GO:0043149)2.37140887
145regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35783289
146cell migration involved in sprouting angiogenesis (GO:0002042)2.35749570
147pericardium development (GO:0060039)2.35598895
148neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.34859993
149exogenous drug catabolic process (GO:0042738)2.34846437
150cell-substrate junction assembly (GO:0007044)2.34487967
151carboxylic acid catabolic process (GO:0046395)2.34446150
152organic acid catabolic process (GO:0016054)2.34446150
153establishment or maintenance of monopolar cell polarity (GO:0061339)2.32907077
154establishment of monopolar cell polarity (GO:0061162)2.32907077
155blood vessel maturation (GO:0001955)2.32839981
156cell volume homeostasis (GO:0006884)2.31472761
157adherens junction assembly (GO:0034333)2.30822413
158regulation of axon extension involved in axon guidance (GO:0048841)2.30360001
159bile acid and bile salt transport (GO:0015721)2.30146632
160cytoskeletal anchoring at plasma membrane (GO:0007016)2.29613525
161regulation of bile acid biosynthetic process (GO:0070857)2.29269803
162extracellular matrix disassembly (GO:0022617)2.28626884
163oxaloacetate metabolic process (GO:0006107)2.28382850
164positive regulation of glycogen biosynthetic process (GO:0045725)2.28271363
165arginine metabolic process (GO:0006525)2.27925270
166substrate-dependent cell migration (GO:0006929)2.27592538
167valine metabolic process (GO:0006573)2.27573809
168multicellular organismal catabolic process (GO:0044243)2.27279560
169cellular response to vitamin (GO:0071295)2.27146754
170embryonic digestive tract morphogenesis (GO:0048557)2.26932501
171fibrinolysis (GO:0042730)2.26924784
172convergent extension (GO:0060026)2.26635933
173carnitine transmembrane transport (GO:1902603)2.26175137
174developmental cell growth (GO:0048588)2.25827882
175negative regulation of sterol transport (GO:0032372)2.25749637
176negative regulation of cholesterol transport (GO:0032375)2.25749637
177benzene-containing compound metabolic process (GO:0042537)2.24604330
178positive regulation of triglyceride metabolic process (GO:0090208)2.23617355
179extracellular matrix organization (GO:0030198)2.23324359
180extracellular structure organization (GO:0043062)2.23218451
181non-canonical Wnt signaling pathway (GO:0035567)2.22260357
182tooth mineralization (GO:0034505)2.21687462
183positive regulation of fibroblast migration (GO:0010763)2.21615265
184sodium ion export (GO:0071436)2.20473038
185regulation of short-term neuronal synaptic plasticity (GO:0048172)2.19936110
186myelination in peripheral nervous system (GO:0022011)2.19430955
187peripheral nervous system axon ensheathment (GO:0032292)2.19430955
188cell-substrate adherens junction assembly (GO:0007045)2.19344483
189focal adhesion assembly (GO:0048041)2.19344483
190apoptotic cell clearance (GO:0043277)2.15870449
191artery development (GO:0060840)2.13859117
192heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.13296021
193myoblast fusion (GO:0007520)2.11410462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.82137571
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.50869560
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.47558019
4* LXR_22158963_ChIP-Seq_LIVER_Mouse2.95743523
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.82627674
6NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.42361328
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.31851664
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09187135
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02268202
10EZH2_22144423_ChIP-Seq_EOC_Human2.01198127
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99252913
12TRIM28_21343339_ChIP-Seq_HEK293_Human1.98377278
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91660455
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91660455
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85091560
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82998589
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.80936795
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80289971
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78022297
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76338984
21CLOCK_20551151_ChIP-Seq_293T_Human1.75893617
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.75820788
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72336309
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71865495
25DROSHA_22980978_ChIP-Seq_HELA_Human1.71371184
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.69578306
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67641728
28* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67202306
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65314930
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65290094
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.63553429
32GBX2_23144817_ChIP-Seq_PC3_Human1.63453001
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61567504
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59301009
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51485975
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51288156
37NFIB_24661679_ChIP-Seq_LUNG_Mouse1.51244201
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.49756514
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.46166028
40* EZH2_27304074_Chip-Seq_ESCs_Mouse1.45970875
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45864112
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44284993
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.40966034
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33154731
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.32762264
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32689604
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31242316
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.28649921
49* RNF2_27304074_Chip-Seq_ESCs_Mouse1.25245207
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25036803
51TET1_21490601_ChIP-Seq_MESCs_Mouse1.22333557
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22132729
53* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21533795
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.20559737
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20243287
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19695997
57* TP53_23651856_ChIP-Seq_MEFs_Mouse1.18809775
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18067723
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18067723
60BRD4_25478319_ChIP-Seq_HGPS_Human1.18048752
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17588421
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.17226417
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14835332
64* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13104705
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.12740184
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.12740184
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11988943
68SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11557841
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10079779
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09875519
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09379620
72* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09167307
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08619886
74* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08340161
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07285568
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07244017
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07129340
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06103199
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06087402
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05753876
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04421350
82KDM2B_26808549_Chip-Seq_K562_Human1.04342986
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.01911200
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00364293
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.99583943
86AR_21572438_ChIP-Seq_LNCaP_Human0.99502806
87TP53_22127205_ChIP-Seq_IMR90_Human0.99251195
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98430739
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98349404
90* SA1_22415368_ChIP-Seq_MEFs_Mouse0.96787847
91DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96779960
92NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96621070
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.96258335
94YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96127999
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.95559988
96BCAT_22108803_ChIP-Seq_LS180_Human0.95063683
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.94431903
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.94371125
99AHR_22903824_ChIP-Seq_MCF-7_Human0.93927787
100RING1B_27294783_Chip-Seq_ESCs_Mouse0.92960738
101CJUN_26792858_Chip-Seq_BT549_Human0.92805724
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92635160
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92107332
104RARB_27405468_Chip-Seq_BRAIN_Mouse0.91483466
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91377024
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91051608
107EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90626185
108SMAD4_21799915_ChIP-Seq_A2780_Human0.88986507
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.87701762
110IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87068531
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87024453
112SOX2_21211035_ChIP-Seq_LN229_Gbm0.86845471
113LXR_22292898_ChIP-Seq_THP-1_Human0.85212003
114AR_19668381_ChIP-Seq_PC3_Human0.84512586
115ARNT_22903824_ChIP-Seq_MCF-7_Human0.84017223
116RXR_22108803_ChIP-Seq_LS180_Human0.83772246
117TP53_18474530_ChIP-ChIP_U2OS_Human0.83048680
118CTCF_27219007_Chip-Seq_Bcells_Human0.81073830
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80668751
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78898502
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78754112
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77884779
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76628082
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76478258
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.76431349
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76417437
127REST_21632747_ChIP-Seq_MESCs_Mouse0.76113548
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74825684
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74332029
130TP53_16413492_ChIP-PET_HCT116_Human0.73245754
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72988649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.64416887
2MP0005360_urolithiasis4.12167830
3MP0005085_abnormal_gallbladder_physiolo3.57710173
4MP0005365_abnormal_bile_salt3.43640379
5MP0008438_abnormal_cutaneous_collagen3.18756717
6MP0002837_dystrophic_cardiac_calcinosis3.01402147
7MP0008875_abnormal_xenobiotic_pharmacok2.84383131
8MP0000751_myopathy2.78273586
9MP0005257_abnormal_intraocular_pressure2.68178263
10MP0003252_abnormal_bile_duct2.58912635
11MP0010030_abnormal_orbit_morphology2.56584817
12MP0010329_abnormal_lipoprotein_level2.38178668
13MP0005503_abnormal_tendon_morphology2.20514511
14MP0004130_abnormal_muscle_cell2.10552226
15MP0003705_abnormal_hypodermis_morpholog2.05878894
16MP0005275_abnormal_skin_tensile1.99017478
17MP0005083_abnormal_biliary_tract1.96247669
18MP0010368_abnormal_lymphatic_system1.95126757
19MP0003279_aneurysm1.93358448
20MP0005508_abnormal_skeleton_morphology1.84298811
21MP0009780_abnormal_chondrocyte_physiolo1.75563940
22MP0000462_abnormal_digestive_system1.75411806
23MP0003646_muscle_fatigue1.74919784
24MP0005670_abnormal_white_adipose1.73363148
25MP0003195_calcinosis1.67034936
26MP0001958_emphysema1.64968969
27MP0001542_abnormal_bone_strength1.64722604
28MP0005332_abnormal_amino_acid1.62170527
29MP0004859_abnormal_synaptic_plasticity1.61571896
30MP0004084_abnormal_cardiac_muscle1.60306687
31MP0006054_spinal_hemorrhage1.56733277
32MP0003566_abnormal_cell_adhesion1.56445679
33MP0004272_abnormal_basement_membrane1.55489103
34MP0002249_abnormal_larynx_morphology1.55296536
35MP0002060_abnormal_skin_morphology1.53241447
36MP0002118_abnormal_lipid_homeostasis1.52039324
37MP0000749_muscle_degeneration1.45841791
38MP0003806_abnormal_nucleotide_metabolis1.42096987
39* MP0009250_abnormal_appendicular_skeleto1.41982283
40* MP0004036_abnormal_muscle_relaxation1.40043700
41MP0009840_abnormal_foam_cell1.36411027
42MP0009384_cardiac_valve_regurgitation1.34192763
43MP0003941_abnormal_skin_development1.33895685
44MP0003385_abnormal_body_wall1.32762938
45MP0004145_abnormal_muscle_electrophysio1.31917243
46MP0003191_abnormal_cellular_cholesterol1.31665010
47MP0004215_abnormal_myocardial_fiber1.31663572
48MP0002108_abnormal_muscle_morphology1.30896259
49MP0005330_cardiomyopathy1.30503014
50MP0006138_congestive_heart_failure1.25178636
51MP0004087_abnormal_muscle_fiber1.23339660
52MP0005023_abnormal_wound_healing1.18876222
53MP0001666_abnormal_nutrient_absorption1.18065206
54MP0005620_abnormal_muscle_contractility1.15842749
55MP0008775_abnormal_heart_ventricle1.15791113
56MP0001243_abnormal_dermal_layer1.14037290
57MP0009053_abnormal_anal_canal1.13667811
58MP0003868_abnormal_feces_composition1.13103725
59MP0000747_muscle_weakness1.12829210
60MP0003091_abnormal_cell_migration1.11103927
61* MP0000428_abnormal_craniofacial_morphol1.10486187
62MP0000013_abnormal_adipose_tissue1.10448468
63MP0005319_abnormal_enzyme/_coenzyme1.10352728
64MP0004858_abnormal_nervous_system1.08461652
65MP0002909_abnormal_adrenal_gland1.08399100
66MP0003329_amyloid_beta_deposits1.07710732
67MP0005623_abnormal_meninges_morphology1.06515087
68MP0005666_abnormal_adipose_tissue1.06193389
69MP0005409_darkened_coat_color1.04863186
70MP0000762_abnormal_tongue_morphology1.04585831
71MP0000733_abnormal_muscle_development1.03977927
72MP0005584_abnormal_enzyme/coenzyme_acti1.03833419
73MP0000049_abnormal_middle_ear1.03564549
74MP0002295_abnormal_pulmonary_circulatio1.03395925
75MP0003942_abnormal_urinary_system1.03245395
76MP0002269_muscular_atrophy1.01383303
77MP0000609_abnormal_liver_physiology1.00707064
78MP0002972_abnormal_cardiac_muscle0.98850300
79MP0001849_ear_inflammation0.98429442
80MP0005167_abnormal_blood-brain_barrier0.97484405
81MP0005385_cardiovascular_system_phenoty0.96420711
82MP0001544_abnormal_cardiovascular_syste0.96420711
83MP0004085_abnormal_heartbeat0.94822413
84MP0008961_abnormal_basal_metabolism0.94368449
85MP0003635_abnormal_synaptic_transmissio0.93015538
86MP0000759_abnormal_skeletal_muscle0.92239725
87MP0002896_abnormal_bone_mineralization0.90642204
88MP0003283_abnormal_digestive_organ0.90105693
89MP0005595_abnormal_vascular_smooth0.88516736
90MP0005375_adipose_tissue_phenotype0.88131269
91* MP0000163_abnormal_cartilage_morphology0.87552836
92MP0002822_catalepsy0.87321438
93MP0005535_abnormal_body_temperature0.87035643
94MP0005187_abnormal_penis_morphology0.86700852
95MP0004270_analgesia0.86174991
96MP0003137_abnormal_impulse_conducting0.86091354
97MP0005369_muscle_phenotype0.85971943
98MP0002971_abnormal_brown_adipose0.85114149
99MP0003115_abnormal_respiratory_system0.84754459
100MP0001177_atelectasis0.84046376
101MP0000778_abnormal_nervous_system0.83670268
102MP0005171_absent_coat_pigmentation0.83132706
103MP0004019_abnormal_vitamin_homeostasis0.82383089
104MP0002932_abnormal_joint_morphology0.82005260
105MP0001879_abnormal_lymphatic_vessel0.81512163
106MP0003950_abnormal_plasma_membrane0.81191953
107MP0000003_abnormal_adipose_tissue0.81032351
108MP0010386_abnormal_urinary_bladder0.79716711
109* MP0002116_abnormal_craniofacial_bone0.79625753
110MP0002106_abnormal_muscle_physiology0.78866363
111MP0000230_abnormal_systemic_arterial0.78739212
112* MP0002128_abnormal_blood_circulation0.77762142
113MP0010630_abnormal_cardiac_muscle0.77479697
114MP0003045_fibrosis0.76870752
115MP0002168_other_aberrant_phenotype0.76234296
116MP0001968_abnormal_touch/_nociception0.75929288
117* MP0002114_abnormal_axial_skeleton0.74229443
118MP0002734_abnormal_mechanical_nocicepti0.74057819
119* MP0000432_abnormal_head_morphology0.73943744
120MP0004484_altered_response_of0.73938305
121MP0002078_abnormal_glucose_homeostasis0.73766559
122MP0001501_abnormal_sleep_pattern0.73709373
123MP0005334_abnormal_fat_pad0.73607774
124MP0003880_abnormal_central_pattern0.72556090
125MP0002138_abnormal_hepatobiliary_system0.71715214
126MP0001299_abnormal_eye_distance/0.71491673
127MP0000767_abnormal_smooth_muscle0.71301676
128MP0000604_amyloidosis0.71158082
129MP0002876_abnormal_thyroid_physiology0.71147804
130MP0005165_increased_susceptibility_to0.70702804
131MP0009745_abnormal_behavioral_response0.69013754
132MP0002133_abnormal_respiratory_system0.68481926
133MP0005388_respiratory_system_phenotype0.68481926
134* MP0002115_abnormal_skeleton_extremities0.68205007
135MP0002735_abnormal_chemical_nociception0.67732628
136MP0002282_abnormal_trachea_morphology0.67607037
137MP0004134_abnormal_chest_morphology0.67417573
138MP0003755_abnormal_palate_morphology0.65875576
139MP0002234_abnormal_pharynx_morphology0.65780412
140MP0006276_abnormal_autonomic_nervous0.64873196
141MP0001348_abnormal_lacrimal_gland0.64245712
142MP0003935_abnormal_craniofacial_develop0.64211261
143MP0003690_abnormal_glial_cell0.63957077
144MP0003938_abnormal_ear_development0.63299402
145MP0001614_abnormal_blood_vessel0.63265539
146* MP0002233_abnormal_nose_morphology0.63208151
147MP0001915_intracranial_hemorrhage0.63139128
148MP0000534_abnormal_ureter_morphology0.62991485
149MP0000467_abnormal_esophagus_morphology0.62837186
150MP0000678_abnormal_parathyroid_gland0.62308998
151MP0000750_abnormal_muscle_regeneration0.61708424
152MP0005197_abnormal_uvea_morphology0.61216542
153MP0005390_skeleton_phenotype0.59418853
154MP0008569_lethality_at_weaning0.58765805
155MP0003119_abnormal_digestive_system0.58713832

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.67085553
2Vascular tortuosity (HP:0004948)4.38218422
3Soft skin (HP:0000977)4.03951098
4Abnormality of dentin (HP:0010299)3.92349662
5Arterial tortuosity (HP:0005116)3.92141789
6Protrusio acetabuli (HP:0003179)3.73757898
7Follicular hyperkeratosis (HP:0007502)3.66346218
8Xanthomatosis (HP:0000991)3.63864566
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.58634672
10Intrahepatic cholestasis (HP:0001406)3.58428720
11Neonatal short-limb short stature (HP:0008921)3.53699522
12Atrophic scars (HP:0001075)3.36000852
13Hyperlipoproteinemia (HP:0010980)3.34412207
14* Broad metatarsal (HP:0001783)3.28582277
15Complement deficiency (HP:0004431)3.26221969
16Fragile skin (HP:0001030)3.21156244
17Wormian bones (HP:0002645)3.16729957
18Slender build (HP:0001533)3.16438824
19Premature rupture of membranes (HP:0001788)3.03262881
20Ketosis (HP:0001946)2.98411067
21Hypoalphalipoproteinemia (HP:0003233)2.97080599
22Type 1 muscle fiber predominance (HP:0003803)2.96596679
23Cervical subluxation (HP:0003308)2.95379909
24Exercise-induced myalgia (HP:0003738)2.94756269
25Bowel diverticulosis (HP:0005222)2.92223663
26Prolonged partial thromboplastin time (HP:0003645)2.91359458
27Abnormality of monocarboxylic acid metabolism (HP:0010996)2.90426713
28Genu recurvatum (HP:0002816)2.84779292
29Increased variability in muscle fiber diameter (HP:0003557)2.79735571
30Increased connective tissue (HP:0009025)2.71110778
31Ketoacidosis (HP:0001993)2.70969642
32Dilatation of the ascending aorta (HP:0005111)2.67868528
33Hyperammonemia (HP:0001987)2.67619287
34Skin nodule (HP:0200036)2.66334598
35Hypoventilation (HP:0002791)2.66119243
36Hyperextensible skin (HP:0000974)2.63413530
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.61777109
38Hyporeflexia of lower limbs (HP:0002600)2.59616752
39Blue sclerae (HP:0000592)2.58553348
40Round ear (HP:0100830)2.58382309
41Overgrowth (HP:0001548)2.58102718
42* Joint laxity (HP:0001388)2.57176050
43Sudden death (HP:0001699)2.55940805
44Hypolipoproteinemia (HP:0010981)2.55878119
45Wrist flexion contracture (HP:0001239)2.53748948
46Muscle fiber splitting (HP:0003555)2.52332620
47Epidermoid cyst (HP:0200040)2.51663686
48Hypobetalipoproteinemia (HP:0003563)2.51156504
49Vertebral compression fractures (HP:0002953)2.47422568
50Myoglobinuria (HP:0002913)2.46585713
51Turricephaly (HP:0000262)2.45571673
52Biconcave vertebral bodies (HP:0004586)2.45369814
53Wide anterior fontanel (HP:0000260)2.44649255
54Upper limb amyotrophy (HP:0009129)2.44136844
55Distal upper limb amyotrophy (HP:0007149)2.44136844
56Hyperglycinuria (HP:0003108)2.42708161
57Shallow orbits (HP:0000586)2.42368312
58Hypoglycemic coma (HP:0001325)2.41514127
59Coronal craniosynostosis (HP:0004440)2.37371242
60Mitral regurgitation (HP:0001653)2.36680511
61Ulnar bowing (HP:0003031)2.36500812
62Abnormality of skeletal muscle fiber size (HP:0012084)2.36022040
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33599719
64Obstructive sleep apnea (HP:0002870)2.32171324
65Abnormality of the common coagulation pathway (HP:0010990)2.30542371
66Abnormality of glycine metabolism (HP:0010895)2.29672944
67Abnormality of serine family amino acid metabolism (HP:0010894)2.29672944
68Ankle contracture (HP:0006466)2.28716399
69Hyperglycinemia (HP:0002154)2.26519836
70Cerebral aneurysm (HP:0004944)2.24058608
71Lymphangioma (HP:0100764)2.23962823
72Spondylolisthesis (HP:0003302)2.21828880
73Aortic regurgitation (HP:0001659)2.21462972
74Calf muscle hypertrophy (HP:0008981)2.19407974
75Abnormal delivery (HP:0001787)2.18379315
76Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.18350042
77Abnormality of the calf musculature (HP:0001430)2.17471853
78Nemaline bodies (HP:0003798)2.15587120
79Mitral stenosis (HP:0001718)2.15422423
80Limb-girdle muscle weakness (HP:0003325)2.15149900
81Difficulty running (HP:0009046)2.15075469
82Hand muscle atrophy (HP:0009130)2.13133178
83Abnormality of complement system (HP:0005339)2.11333923
84Myotonia (HP:0002486)2.11208039
85Abnormality of the intrinsic pathway (HP:0010989)2.10539024
86Abnormality of fatty-acid metabolism (HP:0004359)2.10145522
87Aortic dissection (HP:0002647)2.10083255
88Joint hemorrhage (HP:0005261)2.09687930
89Mild short stature (HP:0003502)2.08862183
90Exercise-induced muscle cramps (HP:0003710)2.07958176
91Muscle fiber inclusion bodies (HP:0100299)2.07016802
92Right ventricular cardiomyopathy (HP:0011663)2.06779943
93Spinal rigidity (HP:0003306)2.06221087
94Ectopia lentis (HP:0001083)2.04410802
95Cholelithiasis (HP:0001081)2.03496042
96Hip contracture (HP:0003273)2.02816299
97Atrioventricular block (HP:0001678)2.02664198
98Peritonitis (HP:0002586)2.02552882
99Camptodactyly of toe (HP:0001836)2.01037271
100Atelectasis (HP:0100750)2.00755126
101Atrial fibrillation (HP:0005110)1.99526288
102Mitral valve prolapse (HP:0001634)1.98919441
103Limited hip movement (HP:0008800)1.98380526
104Abnormality of the Achilles tendon (HP:0005109)1.98130671
105Bladder diverticulum (HP:0000015)1.97999370
106Muscle hypertrophy of the lower extremities (HP:0008968)1.97528250
107Delayed CNS myelination (HP:0002188)1.97338753
108Gout (HP:0001997)1.97319706
109Neonatal onset (HP:0003623)1.95726988
110Abnormal gallbladder morphology (HP:0012437)1.95566048
111Hydroxyprolinuria (HP:0003080)1.93484902
112Abnormality of proline metabolism (HP:0010907)1.93484902
113Bell-shaped thorax (HP:0001591)1.92572633
114Elbow flexion contracture (HP:0002987)1.91966096
115Mildly elevated creatine phosphokinase (HP:0008180)1.91895559
116Aneurysm (HP:0002617)1.91444311
117Aortic valve stenosis (HP:0001650)1.90319359
118Joint stiffness (HP:0001387)1.87724906
119Torticollis (HP:0000473)1.86813024
120Primary atrial arrhythmia (HP:0001692)1.85854346
121Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85371837
122Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85148477
123Hypercholesterolemia (HP:0003124)1.84246431
124Asymmetric septal hypertrophy (HP:0001670)1.83661665
125Ulnar deviation of the wrist (HP:0003049)1.83482600
126Abnormality of sulfur amino acid metabolism (HP:0004339)1.83021833
127Abnormality of the acetabulum (HP:0003170)1.82671435
128Natal tooth (HP:0000695)1.82147361
129Aortic aneurysm (HP:0004942)1.82076809
130Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82065098
131Disproportionate tall stature (HP:0001519)1.81189275
132Cardiovascular calcification (HP:0011915)1.80802544
133Distal arthrogryposis (HP:0005684)1.80663387
134Heart block (HP:0012722)1.78896151
135Enlarged penis (HP:0000040)1.77612182
136Bundle branch block (HP:0011710)1.77537008
137EMG: myopathic abnormalities (HP:0003458)1.76756722
138Abnormality of the ischium (HP:0003174)1.74661819
139Abnormal atrioventricular conduction (HP:0005150)1.74365189
140Infantile muscular hypotonia (HP:0008947)1.74099698
141Breech presentation (HP:0001623)1.73487796
142Supraventricular arrhythmia (HP:0005115)1.73469464
143Lipoatrophy (HP:0100578)1.71747360
144Hypoplastic ischia (HP:0003175)1.71201408
145Supraventricular tachycardia (HP:0004755)1.70445329
146Action tremor (HP:0002345)1.69245957
147Abnormal gallbladder physiology (HP:0012438)1.68825175
148Cholecystitis (HP:0001082)1.68825175
149Spontaneous abortion (HP:0005268)1.68766977
150Inguinal hernia (HP:0000023)1.68552708
151Narrow nasal bridge (HP:0000446)1.68204709
152Abnormality of purine metabolism (HP:0004352)1.67133187
153Generalized amyotrophy (HP:0003700)1.67015252
154Craniofacial dystonia (HP:0012179)1.66340801
155Abnormality of methionine metabolism (HP:0010901)1.66147429
156Muscle stiffness (HP:0003552)1.65908897
157Calcaneovalgus deformity (HP:0001848)1.65626790
158Protruding ear (HP:0000411)1.65586306
159* Broad long bones (HP:0005622)1.61793361
160Venous insufficiency (HP:0005293)1.61640814
161Achilles tendon contracture (HP:0001771)1.61511527
162Deviation of the hallux (HP:0010051)1.61317741
163Deformed tarsal bones (HP:0008119)1.59866461
164Venous abnormality (HP:0002624)1.59107836
165Coxa vara (HP:0002812)1.58613670
166Absent frontal sinuses (HP:0002688)1.56447638
167Osteoarthritis (HP:0002758)1.55994673
168Spinal cord lesions (HP:0100561)1.55698614
169Syringomyelia (HP:0003396)1.55698614
170Hallux valgus (HP:0001822)1.53570090
171Stridor (HP:0010307)1.53365144
172Insomnia (HP:0100785)1.50946500
173Bradycardia (HP:0001662)1.49776005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB32.97395552
2SIK12.90273948
3TTN2.68237073
4MARK12.40980350
5PKN22.30190266
6RIPK12.27075833
7BCKDK2.25904354
8NTRK32.20654123
9NEK12.16083695
10DDR22.07358734
11TIE12.00757244
12PNCK1.94810347
13INSRR1.93900590
14PHKG11.93309319
15PHKG21.93309319
16LMTK21.82539608
17MET1.79068069
18PDGFRA1.72542242
19MAP2K41.71872085
20MAPK151.64255193
21CAMKK11.60297771
22MYLK1.59715178
23LATS11.56883767
24ERN11.55695956
25FGFR41.52721233
26LIMK11.50030386
27PINK11.49108744
28LATS21.45410464
29DAPK21.42901866
30OBSCN1.42341059
31FER1.42207914
32TESK11.35539307
33PAK31.34162230
34PDGFRB1.28907314
35MAP3K71.27045945
36EPHB21.26430023
37FGFR21.24032966
38STK381.22894288
39PRKD31.21853020
40TAOK21.20642337
41PAK61.18610767
42NTRK11.18294999
43CAMK1D1.18085630
44MAP3K41.17246656
45CAMK1G1.17001991
46PTK2B1.14552061
47KSR21.14248438
48PRKCH1.13203628
49DMPK1.13065375
50PTK61.08845686
51EPHA41.08369343
52RET1.06021574
53ROCK21.05549333
54TGFBR21.02362783
55PIK3CA0.98501891
56MINK10.97907486
57MAP3K60.97778402
58SGK30.96265519
59MARK20.93389322
60PTK20.90066188
61PDK30.89614438
62PDK40.89614438
63MAP3K90.89543789
64MAPK120.86966140
65MAP2K10.86401329
66EEF2K0.85676530
67ROCK10.84471118
68PRPF4B0.83891094
69PIK3CG0.83643456
70EPHB10.80592313
71SGK20.79123554
72SGK4940.79004870
73SGK2230.79004870
74MTOR0.78255213
75MOS0.78126557
76GRK50.77977573
77PRKD10.77284370
78ICK0.75532562
79UHMK10.74607486
80EPHA30.72697165
81CDC42BPA0.71738786
82TAOK10.69226252
83NME10.68506521
84SIK20.68292704
85PRKAA20.67809188
86MAP2K30.67583669
87MAP3K10.67386496
88BMX0.65377524
89CAMK2G0.65162008
90MST1R0.62697805
91PBK0.62692040
92FGFR10.62654210
93TNIK0.62451428
94CAMK10.62356226
95PAK40.62331884
96DAPK30.62237227
97TRPM70.61896044
98MUSK0.61301911
99PRKCG0.60254122
100PRKAA10.59884242
101NTRK20.59594470
102JAK10.59078013
103CAMK40.58630164
104MAPK70.57912270
105AKT30.57843338
106WNK10.57053606
107PRKCZ0.56519555
108STK38L0.55739676
109KSR10.53813681
110FLT30.52957637
111CDK11A0.51409522
112CAMK2A0.51113383
113ERBB40.50934205
114CAMK2B0.50871304
115ARAF0.50741994
116PDK20.50656374
117PAK20.50207143
118ERBB20.50120812
119MAP3K20.49814196
120FGFR30.49707208
121DYRK1B0.49355053
122CDK150.49197741
123STK110.49135931
124PDPK10.49042915
125PRKACG0.48146300
126TYRO30.47893080
127PRKD20.47771047
128PRKCE0.47681343
129CDK50.46880706
130MAP2K70.46057846
131RPS6KA20.45492234
132CAMK2D0.45345890
133CASK0.44385170
134NEK90.44246221
135PRKG20.42212914
136CDK180.40554005
137SMG10.38536996
138ADRBK10.37321385
139MAPK40.37035786

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.23625166
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16792200
3Nitrogen metabolism_Homo sapiens_hsa009103.13042049
4Arginine biosynthesis_Homo sapiens_hsa002202.51844918
5Fatty acid degradation_Homo sapiens_hsa000712.38817448
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12025918
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10691421
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10494319
9Tryptophan metabolism_Homo sapiens_hsa003802.07394021
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96045760
11Propanoate metabolism_Homo sapiens_hsa006401.95832567
12Fatty acid metabolism_Homo sapiens_hsa012121.92006665
13Complement and coagulation cascades_Homo sapiens_hsa046101.90516248
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90097036
15PPAR signaling pathway_Homo sapiens_hsa033201.89296142
16Butanoate metabolism_Homo sapiens_hsa006501.86146217
17Bile secretion_Homo sapiens_hsa049761.75208924
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67479025
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50807226
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47980752
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39171733
22Peroxisome_Homo sapiens_hsa041461.38357187
23Caffeine metabolism_Homo sapiens_hsa002321.37617837
24Pyruvate metabolism_Homo sapiens_hsa006201.31381539
25Cocaine addiction_Homo sapiens_hsa050301.27114335
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24300510
27beta-Alanine metabolism_Homo sapiens_hsa004101.22985019
28Proteoglycans in cancer_Homo sapiens_hsa052051.22679344
29Starch and sucrose metabolism_Homo sapiens_hsa005001.19934214
30Hedgehog signaling pathway_Homo sapiens_hsa043401.19284725
31Basal cell carcinoma_Homo sapiens_hsa052171.17595666
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15193825
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14991590
34Melanogenesis_Homo sapiens_hsa049161.13844312
35Axon guidance_Homo sapiens_hsa043601.13778967
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.13673210
37Phenylalanine metabolism_Homo sapiens_hsa003601.11903901
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.11025324
39Adherens junction_Homo sapiens_hsa045201.10438000
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08799626
41Tight junction_Homo sapiens_hsa045301.08431378
42Dilated cardiomyopathy_Homo sapiens_hsa054141.07347713
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05207236
44Chemical carcinogenesis_Homo sapiens_hsa052041.04789211
45Gap junction_Homo sapiens_hsa045401.02104804
46Long-term potentiation_Homo sapiens_hsa047200.99792238
47Tyrosine metabolism_Homo sapiens_hsa003500.99355980
48Carbon metabolism_Homo sapiens_hsa012000.98436840
49* Vascular smooth muscle contraction_Homo sapiens_hsa042700.97891262
50Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96995340
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.96191948
52Hippo signaling pathway_Homo sapiens_hsa043900.94720503
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91438327
54Estrogen signaling pathway_Homo sapiens_hsa049150.87971181
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87690360
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87019711
57Glioma_Homo sapiens_hsa052140.86664081
58Fatty acid biosynthesis_Homo sapiens_hsa000610.85957489
59Lysine degradation_Homo sapiens_hsa003100.85812415
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85331883
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85027512
62PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84954238
63Histidine metabolism_Homo sapiens_hsa003400.84006037
64ECM-receptor interaction_Homo sapiens_hsa045120.83566069
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83009401
66ABC transporters_Homo sapiens_hsa020100.82783951
67Fatty acid elongation_Homo sapiens_hsa000620.81509879
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81269920
69Circadian entrainment_Homo sapiens_hsa047130.80673903
70Retinol metabolism_Homo sapiens_hsa008300.80133763
71GABAergic synapse_Homo sapiens_hsa047270.78376639
72Vitamin B6 metabolism_Homo sapiens_hsa007500.77199537
73Wnt signaling pathway_Homo sapiens_hsa043100.76175201
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75862532
75Staphylococcus aureus infection_Homo sapiens_hsa051500.74826935
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74489110
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.73486252
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72825982
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72113262
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.71494280
81Rap1 signaling pathway_Homo sapiens_hsa040150.71395783
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71091684
83TGF-beta signaling pathway_Homo sapiens_hsa043500.70487547
84Melanoma_Homo sapiens_hsa052180.70227679
85Biosynthesis of amino acids_Homo sapiens_hsa012300.69843641
86Insulin resistance_Homo sapiens_hsa049310.69585500
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69261679
88Arginine and proline metabolism_Homo sapiens_hsa003300.68574176
89Dopaminergic synapse_Homo sapiens_hsa047280.68428278
90Glucagon signaling pathway_Homo sapiens_hsa049220.68350553
91Circadian rhythm_Homo sapiens_hsa047100.67570500
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66754199
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65410193
94Insulin secretion_Homo sapiens_hsa049110.65183745
95Notch signaling pathway_Homo sapiens_hsa043300.63042542
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62009340
97Glycerolipid metabolism_Homo sapiens_hsa005610.61723937
98Ovarian steroidogenesis_Homo sapiens_hsa049130.61374053
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61332237
100Fat digestion and absorption_Homo sapiens_hsa049750.61309383
101Salivary secretion_Homo sapiens_hsa049700.61222674
102Cardiac muscle contraction_Homo sapiens_hsa042600.59767628
103Choline metabolism in cancer_Homo sapiens_hsa052310.58893122
104Renin secretion_Homo sapiens_hsa049240.58828958
105Nicotine addiction_Homo sapiens_hsa050330.58091111
106Glutamatergic synapse_Homo sapiens_hsa047240.57865815
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.57851787
108Prion diseases_Homo sapiens_hsa050200.57726570
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57670342
110Small cell lung cancer_Homo sapiens_hsa052220.57546582
111Focal adhesion_Homo sapiens_hsa045100.57139727
112Ras signaling pathway_Homo sapiens_hsa040140.56816250
113Insulin signaling pathway_Homo sapiens_hsa049100.56736330
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56500761
115Pathways in cancer_Homo sapiens_hsa052000.55557258
116Endometrial cancer_Homo sapiens_hsa052130.54791856
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54723293
118Gastric acid secretion_Homo sapiens_hsa049710.54690736
119Type II diabetes mellitus_Homo sapiens_hsa049300.54421223
120Protein digestion and absorption_Homo sapiens_hsa049740.54181975
121Sulfur metabolism_Homo sapiens_hsa009200.53092580
122AMPK signaling pathway_Homo sapiens_hsa041520.49667281
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.48208491
124Thyroid hormone synthesis_Homo sapiens_hsa049180.47787934
125Olfactory transduction_Homo sapiens_hsa047400.47483709
126Synaptic vesicle cycle_Homo sapiens_hsa047210.45266198
127Calcium signaling pathway_Homo sapiens_hsa040200.44763064
128Morphine addiction_Homo sapiens_hsa050320.44667897
129* Oxytocin signaling pathway_Homo sapiens_hsa049210.44642714
130cAMP signaling pathway_Homo sapiens_hsa040240.42505238
131Amoebiasis_Homo sapiens_hsa051460.41323139
132GnRH signaling pathway_Homo sapiens_hsa049120.41290053
133Cholinergic synapse_Homo sapiens_hsa047250.41039629
134* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40463011
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39130321
136Taste transduction_Homo sapiens_hsa047420.39107149
137Amphetamine addiction_Homo sapiens_hsa050310.38528048
138Selenocompound metabolism_Homo sapiens_hsa004500.38189675
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38000104

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