NPR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)8.79521912
2endothelium development (GO:0003158)8.40015415
3definitive hemopoiesis (GO:0060216)8.02268904
4positive regulation of vasculogenesis (GO:2001214)7.08543636
5regulation of sequestering of triglyceride (GO:0010889)6.98332936
6triglyceride catabolic process (GO:0019433)6.67006505
7white fat cell differentiation (GO:0050872)6.42916196
8positive regulation of fatty acid beta-oxidation (GO:0032000)6.11815118
9brown fat cell differentiation (GO:0050873)5.99574217
10neutral lipid catabolic process (GO:0046461)5.98396444
11acylglycerol catabolic process (GO:0046464)5.98396444
12response to dietary excess (GO:0002021)5.75837098
13positive regulation of fatty acid oxidation (GO:0046321)5.65655336
14blood vessel maturation (GO:0001955)5.31303154
15valine metabolic process (GO:0006573)5.29334005
16lipid particle organization (GO:0034389)5.28720302
17ovulation from ovarian follicle (GO:0001542)5.26491536
18negative regulation of erythrocyte differentiation (GO:0045647)5.18994626
19aggressive behavior (GO:0002118)5.18955891
20fatty acid transmembrane transport (GO:1902001)5.16941484
21positive regulation of vascular permeability (GO:0043117)5.09255267
22biotin metabolic process (GO:0006768)5.02946042
23regulation of vasculogenesis (GO:2001212)5.02689688
24positive regulation of cellular response to insulin stimulus (GO:1900078)4.95852782
25protein heterotrimerization (GO:0070208)4.87062963
26positive regulation of insulin receptor signaling pathway (GO:0046628)4.83735588
27regulation of cholesterol storage (GO:0010885)4.77666136
28negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.71467125
29retina vasculature morphogenesis in camera-type eye (GO:0061299)4.67226792
30triglyceride biosynthetic process (GO:0019432)4.57542969
31cell differentiation involved in metanephros development (GO:0072202)4.56430111
32regulation of fatty acid beta-oxidation (GO:0031998)4.50827072
33fatty acid beta-oxidation (GO:0006635)4.46928422
34neutral lipid biosynthetic process (GO:0046460)4.46644032
35acylglycerol biosynthetic process (GO:0046463)4.46644032
36lipid storage (GO:0019915)4.41927075
37carnitine shuttle (GO:0006853)4.40995681
38glomerular basement membrane development (GO:0032836)4.40423331
39glycerolipid catabolic process (GO:0046503)4.34358414
40epithelial cell differentiation involved in kidney development (GO:0035850)4.32817598
41positive regulation of odontogenesis (GO:0042482)4.29149505
42regulation of fatty acid oxidation (GO:0046320)4.15717169
43regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.15140562
44cellular response to antibiotic (GO:0071236)4.07323304
45angiogenesis involved in wound healing (GO:0060055)3.98066455
46fatty acid homeostasis (GO:0055089)3.87632736
47extracellular fibril organization (GO:0043206)3.87083164
48response to vitamin E (GO:0033197)3.86836580
49positive regulation of glucose import (GO:0046326)3.85150548
50fatty acid oxidation (GO:0019395)3.84069504
51growth hormone receptor signaling pathway (GO:0060396)3.82932910
52negative regulation of vascular permeability (GO:0043116)3.81818533
53negative regulation of nitric oxide biosynthetic process (GO:0045019)3.79855328
54lipid oxidation (GO:0034440)3.76318813
55glomerular visceral epithelial cell development (GO:0072015)3.76241789
56positive regulation of B cell differentiation (GO:0045579)3.75733678
57sequestering of extracellular ligand from receptor (GO:0035581)3.75005067
58tyrosine phosphorylation of STAT protein (GO:0007260)3.74764441
59cellular response to vitamin (GO:0071295)3.72796077
60negative regulation of protein autophosphorylation (GO:0031953)3.71881431
61progesterone metabolic process (GO:0042448)3.69583697
62fatty acid catabolic process (GO:0009062)3.69478249
63positive regulation of fatty acid metabolic process (GO:0045923)3.66242311
64cellular response to exogenous dsRNA (GO:0071360)3.64176470
65megakaryocyte development (GO:0035855)3.63379888
66triglyceride metabolic process (GO:0006641)3.60169518
67glomerular filtration (GO:0003094)3.56124425
68interkinetic nuclear migration (GO:0022027)3.55204577
69renal filtration (GO:0097205)3.54732730
70positive regulation of lipid catabolic process (GO:0050996)3.54117616
71coenzyme A biosynthetic process (GO:0015937)3.53618173
72hematopoietic stem cell proliferation (GO:0071425)3.53581093
73glycerol metabolic process (GO:0006071)3.53280511
74insulin-like growth factor receptor signaling pathway (GO:0048009)3.53201497
75regulation of cAMP-dependent protein kinase activity (GO:2000479)3.52787516
76thrombin receptor signaling pathway (GO:0070493)3.50969339
77carnitine transmembrane transport (GO:1902603)3.46000545
78regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.45577977
79acylglycerol metabolic process (GO:0006639)3.44725626
80regulation of macrophage derived foam cell differentiation (GO:0010743)3.44385401
81branched-chain amino acid metabolic process (GO:0009081)3.42582367
82lymph vessel development (GO:0001945)3.42361522
83sprouting angiogenesis (GO:0002040)3.41060142
84neutral lipid metabolic process (GO:0006638)3.40029343
85plasma lipoprotein particle clearance (GO:0034381)3.39180084
86negative regulation of phagocytosis (GO:0050765)3.35333808
87fatty-acyl-CoA metabolic process (GO:0035337)3.35050714
88apoptotic cell clearance (GO:0043277)3.32681787
89positive regulation of glomerulus development (GO:0090193)3.31958334
90long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.30273101
91negative regulation of granulocyte differentiation (GO:0030853)3.30149889
92diacylglycerol metabolic process (GO:0046339)3.29907536
93cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.29846539
94glomerular epithelial cell development (GO:0072310)3.28065749
95cellular response to growth hormone stimulus (GO:0071378)3.27519551
96cellular response to lithium ion (GO:0071285)3.25707570
97vascular endothelial growth factor signaling pathway (GO:0038084)3.25501841
98thyroid gland development (GO:0030878)3.23018620
99fibril organization (GO:0097435)3.22457738
100positive regulation of glycogen biosynthetic process (GO:0045725)3.21811665
101keratan sulfate catabolic process (GO:0042340)3.21536212
102phagocytosis, recognition (GO:0006910)3.21243444
103alpha-linolenic acid metabolic process (GO:0036109)3.20277162
104regulation of glycogen (starch) synthase activity (GO:2000465)3.19599775
105UV protection (GO:0009650)3.19558304
106regulation of female gonad development (GO:2000194)3.18592721
107positive regulation of lipid storage (GO:0010884)3.18202204
108positive regulation of glucose transport (GO:0010828)3.17377018
109androgen biosynthetic process (GO:0006702)3.17259776
110fatty-acyl-CoA biosynthetic process (GO:0046949)3.17025469
111collagen fibril organization (GO:0030199)3.16883859
112branched-chain amino acid catabolic process (GO:0009083)3.16282037
113carnitine transport (GO:0015879)3.14338968
114amino-acid betaine transport (GO:0015838)3.14338968
115drinking behavior (GO:0042756)3.13441375
116negative regulation of metanephros development (GO:0072217)3.13421343
117thioester biosynthetic process (GO:0035384)3.13344631
118acyl-CoA biosynthetic process (GO:0071616)3.13344631
119heparin metabolic process (GO:0030202)3.11369899
120heparin biosynthetic process (GO:0030210)3.11369899
121positive regulation of transforming growth factor beta production (GO:0071636)3.08699363
122nephron epithelium development (GO:0072009)3.07875309
123alditol metabolic process (GO:0019400)3.06151921
124mature B cell differentiation involved in immune response (GO:0002313)3.05024311
125regulation of gonadotropin secretion (GO:0032276)3.04686399
126long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.04568454
127regulation of glucose import in response to insulin stimulus (GO:2001273)3.03770924
128axon extension involved in axon guidance (GO:0048846)3.02874200
129neuron projection extension involved in neuron projection guidance (GO:1902284)3.02874200
130quaternary ammonium group transport (GO:0015697)3.02571928
131endothelial cell proliferation (GO:0001935)3.00745604
132negative regulation of lipid storage (GO:0010888)3.00256450
133ovulation (GO:0030728)2.99571945
134oxaloacetate metabolic process (GO:0006107)2.99418193
135positive regulation of macrophage cytokine production (GO:0060907)2.98361368
136mesenchymal-epithelial cell signaling (GO:0060638)2.98083616
137regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.97305238
138intracellular lipid transport (GO:0032365)2.95422597
139negative regulation of amino acid transport (GO:0051956)2.93003028
140regulation of vascular permeability (GO:0043114)2.92935858
141pinocytosis (GO:0006907)2.92238334
142cellular response to epinephrine stimulus (GO:0071872)2.92120470
143bundle of His cell to Purkinje myocyte communication (GO:0086069)2.91924369
144positive regulation of histone deacetylation (GO:0031065)2.91835827
145tricarboxylic acid metabolic process (GO:0072350)2.91186037
146endodermal cell differentiation (GO:0035987)2.91001927
147CDP-diacylglycerol biosynthetic process (GO:0016024)2.90705545
148negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.89733228
149negative regulation of digestive system process (GO:0060457)2.85626869
150negative regulation of macrophage differentiation (GO:0045650)2.80495982
151positive regulation of blood vessel endothelial cell migration (GO:0043536)2.74619351
152activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.73040555
153response to growth hormone (GO:0060416)2.67014672
154histamine secretion (GO:0001821)2.65090789
155hemoglobin metabolic process (GO:0020027)2.65078388
156regulation of female receptivity (GO:0045924)2.64854718
157dermatan sulfate metabolic process (GO:0030205)2.62210622
158hemopoiesis (GO:0030097)2.61368147
159metanephric mesenchyme development (GO:0072075)2.60532637
160regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.60330750
161negative regulation of smooth muscle cell migration (GO:0014912)2.59583598
162cyclooxygenase pathway (GO:0019371)2.57971290
163response to epinephrine (GO:0071871)2.57516147
164mannose metabolic process (GO:0006013)2.57496356
165estrogen biosynthetic process (GO:0006703)2.56515222
166protein localization to cell surface (GO:0034394)2.53935628
167histamine transport (GO:0051608)2.53888893
168cellular response to toxic substance (GO:0097237)2.53293528
169peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.52684942
170negative regulation of cell size (GO:0045792)2.52518300
171regulation of erythrocyte differentiation (GO:0045646)2.51425208
172regulation of integrin activation (GO:0033623)2.51227137
173cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.51180277
174embryonic viscerocranium morphogenesis (GO:0048703)2.50910367
175aminoglycoside antibiotic metabolic process (GO:0030647)2.49313823
176regulation of granulocyte differentiation (GO:0030852)2.48285244
177positive regulation of granulocyte differentiation (GO:0030854)2.47309146
178cell migration involved in heart development (GO:0060973)2.45072238
179gap junction assembly (GO:0016264)2.44843996
180hepatocyte differentiation (GO:0070365)2.44523096
181endothelial cell morphogenesis (GO:0001886)2.43966195
182regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.42851249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.40797028
2SCL_19346495_ChIP-Seq_HPC-7_Human4.36110431
3* CLOCK_20551151_ChIP-Seq_293T_Human4.27938605
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.88590423
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.82148138
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.62207088
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.52692914
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.33819365
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.21629902
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.13496943
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.73250023
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56533213
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.47050431
14PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.45243802
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34717184
16PPAR_26484153_Chip-Seq_NCI-H1993_Human2.03591208
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.00013826
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse11.9368484
19* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.96821333
20LXR_22158963_ChIP-Seq_LIVER_Mouse1.95310796
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.92401304
22* EP300_21415370_ChIP-Seq_HL-1_Mouse1.88655073
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83802333
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82667850
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79546736
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79344900
27GATA1_22025678_ChIP-Seq_K562_Human1.76632816
28CJUN_26792858_Chip-Seq_BT549_Human1.74949713
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.73413599
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72794274
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71481374
32FUS_26573619_Chip-Seq_HEK293_Human1.71080656
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68839829
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.65032814
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63210066
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63113835
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59999550
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.59532257
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.57966964
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56700890
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54518011
42* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53762388
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.51170217
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.47925567
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.47925567
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.46595605
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46203195
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41651095
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39941753
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39240757
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37816132
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37816132
53* SA1_22415368_ChIP-Seq_MEFs_Mouse1.35922953
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35804484
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35039140
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34223507
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.33539019
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.33135027
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.32158284
60VDR_24763502_ChIP-Seq_THP-1_Human1.30349775
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29526684
62IGF1R_20145208_ChIP-Seq_DFB_Human1.29128183
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28708380
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27969951
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26274575
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25396555
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.25335968
68GATA2_19941826_ChIP-Seq_K562_Human1.23805177
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23205417
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22806995
71* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22685891
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.22611840
73RXR_22108803_ChIP-Seq_LS180_Human1.21056640
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20362886
75* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20268068
76* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20268068
77BRD4_25478319_ChIP-Seq_HGPS_Human1.19864270
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19602120
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19004868
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15810101
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.15463965
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14781531
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13545284
84RUNX_20019798_ChIP-Seq_JUKART_Human1.13542392
85ZNF263_19887448_ChIP-Seq_K562_Human1.11977060
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09753358
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09147891
88VDR_24787735_ChIP-Seq_THP-1_Human1.08485303
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07992357
90SOX2_20726797_ChIP-Seq_SW620_Human1.05717329
91BCAT_22108803_ChIP-Seq_LS180_Human1.03496144
92AHR_22903824_ChIP-Seq_MCF-7_Human1.02960721
93* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99286904
94TP53_16413492_ChIP-PET_HCT116_Human0.96442650
95* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96342270
96* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95942575
97NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95052861
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94259821
99TP53_18474530_ChIP-ChIP_U2OS_Human0.93987913
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93047908
101UBF1/2_26484160_Chip-Seq_HMECs_Human0.92320751
102VDR_21846776_ChIP-Seq_THP-1_Human0.91409977
103* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90502516
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90032326
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89340951
106ISL1_27105846_Chip-Seq_CPCs_Mouse0.88400082
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87768365
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87365888
109MYB_26560356_Chip-Seq_TH2_Human0.85551063
110ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85341138
111* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84654792
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84489277
113GATA1_19941826_ChIP-Seq_K562_Human0.84246324
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83818968
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83818968
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.83672053
117EED_16625203_ChIP-ChIP_MESCs_Mouse0.83137667
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82480177
119* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82178675
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82147489
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81799756
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81454606
123* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81352322
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81140490
125* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80981584
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80596449
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80593302
128GBX2_23144817_ChIP-Seq_PC3_Human0.80270398
129* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.80221849
130FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79870435
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79312142
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.79179489
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78431955
134RUNX1_22412390_ChIP-Seq_EML_Mouse0.77996374
135* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77556333
136* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77233181
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76315346
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.75393705
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74920851
140* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.74894254
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74844232
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73829644
143IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72064494
144NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.71706218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose7.36293900
2MP0008438_abnormal_cutaneous_collagen6.02450255
3MP0005666_abnormal_adipose_tissue4.98104764
4MP0004130_abnormal_muscle_cell4.47427730
5MP0004185_abnormal_adipocyte_glucose4.16026967
6MP0005275_abnormal_skin_tensile3.79966448
7* MP0005375_adipose_tissue_phenotype3.51490263
8MP0002837_dystrophic_cardiac_calcinosis3.27808561
9MP0004272_abnormal_basement_membrane3.18937020
10MP0006054_spinal_hemorrhage3.14946974
11MP0002876_abnormal_thyroid_physiology3.03769731
12MP0002396_abnormal_hematopoietic_system2.88779344
13MP0003705_abnormal_hypodermis_morpholog2.81309361
14MP0002971_abnormal_brown_adipose2.60264544
15MP0009115_abnormal_fat_cell2.54238498
16MP0004808_abnormal_hematopoietic_stem2.45404929
17MP0010329_abnormal_lipoprotein_level2.21546111
18* MP0000003_abnormal_adipose_tissue2.14575026
19MP0001661_extended_life_span2.09262521
20MP0003191_abnormal_cellular_cholesterol2.07914090
21* MP0005334_abnormal_fat_pad1.81876271
22MP0002970_abnormal_white_adipose1.78541344
23MP0000465_gastrointestinal_hemorrhage1.75352429
24MP0003959_abnormal_lean_body1.74689966
25MP0000767_abnormal_smooth_muscle1.71585499
26MP0003828_pulmonary_edema1.59650339
27MP0003690_abnormal_glial_cell1.56145687
28MP0005397_hematopoietic_system_phenotyp1.54936839
29MP0001545_abnormal_hematopoietic_system1.54936839
30MP0009780_abnormal_chondrocyte_physiolo1.54092683
31MP0005165_increased_susceptibility_to1.52358517
32* MP0000013_abnormal_adipose_tissue1.52217445
33MP0001879_abnormal_lymphatic_vessel1.50789237
34MP0006138_congestive_heart_failure1.49765860
35MP0002118_abnormal_lipid_homeostasis1.49759951
36MP0003566_abnormal_cell_adhesion1.46591447
37MP0005623_abnormal_meninges_morphology1.45727075
38MP0003045_fibrosis1.40396817
39MP0005535_abnormal_body_temperature1.37208975
40MP0003279_aneurysm1.36023963
41MP0001958_emphysema1.34803488
42MP0008004_abnormal_stomach_pH1.32208390
43MP0005503_abnormal_tendon_morphology1.30942902
44MP0009250_abnormal_appendicular_skeleto1.30307028
45MP0009278_abnormal_bone_marrow1.29068319
46MP0005464_abnormal_platelet_physiology1.28744377
47MP0009697_abnormal_copulation1.27731709
48MP0008775_abnormal_heart_ventricle1.25575848
49MP0002166_altered_tumor_susceptibility1.22939636
50MP0000751_myopathy1.22768946
51MP0002060_abnormal_skin_morphology1.20826770
52MP0003724_increased_susceptibility_to1.19284453
53MP0002295_abnormal_pulmonary_circulatio1.16626884
54MP0004215_abnormal_myocardial_fiber1.14738374
55MP0001544_abnormal_cardiovascular_syste1.13007063
56MP0005385_cardiovascular_system_phenoty1.13007063
57MP0004084_abnormal_cardiac_muscle1.11248745
58MP0005448_abnormal_energy_balance1.10654551
59MP0003186_abnormal_redox_activity1.09908816
60MP0005620_abnormal_muscle_contractility1.09548964
61MP0009384_cardiac_valve_regurgitation1.06845315
62MP0004087_abnormal_muscle_fiber1.06485332
63MP0002108_abnormal_muscle_morphology1.05398696
64MP0005452_abnormal_adipose_tissue1.04688681
65MP0000681_abnormal_thyroid_gland1.02490425
66MP0005023_abnormal_wound_healing1.01206018
67MP0002933_joint_inflammation1.01033666
68MP0000750_abnormal_muscle_regeneration1.00908341
69MP0003950_abnormal_plasma_membrane1.00843059
70MP0002909_abnormal_adrenal_gland1.00636010
71MP0010368_abnormal_lymphatic_system1.00376389
72MP0002168_other_aberrant_phenotype0.97350026
73MP0000343_altered_response_to0.96757302
74MP0001727_abnormal_embryo_implantation0.96186453
75MP0000759_abnormal_skeletal_muscle0.95110069
76* MP0000230_abnormal_systemic_arterial0.94419337
77MP0004134_abnormal_chest_morphology0.93485997
78MP0001501_abnormal_sleep_pattern0.90390743
79MP0004782_abnormal_surfactant_physiolog0.89999986
80MP0002972_abnormal_cardiac_muscle0.89508049
81MP0002006_tumorigenesis0.87966504
82MP0005390_skeleton_phenotype0.87265198
83MP0002127_abnormal_cardiovascular_syste0.87172644
84MP0002160_abnormal_reproductive_system0.86287330
85MP0005330_cardiomyopathy0.85574248
86MP0002925_abnormal_cardiovascular_devel0.84924234
87MP0002078_abnormal_glucose_homeostasis0.84461866
88MP0000609_abnormal_liver_physiology0.81700454
89MP0003091_abnormal_cell_migration0.79951462
90MP0005379_endocrine/exocrine_gland_phen0.79611670
91MP0004036_abnormal_muscle_relaxation0.79327369
92MP0003656_abnormal_erythrocyte_physiolo0.78449721
93MP0003385_abnormal_body_wall0.77262100
94MP0005164_abnormal_response_to0.74908149
95MP0001542_abnormal_bone_strength0.74545206
96MP0001177_atelectasis0.74433430
97MP0001881_abnormal_mammary_gland0.73959640
98MP0002133_abnormal_respiratory_system0.73713042
99MP0005388_respiratory_system_phenotype0.73713042
100MP0010630_abnormal_cardiac_muscle0.73632930
101MP0005167_abnormal_blood-brain_barrier0.73632445
102MP0003948_abnormal_gas_homeostasis0.73368738
103MP0000266_abnormal_heart_morphology0.73045812
104MP0003300_gastrointestinal_ulcer0.72614423
105MP0005595_abnormal_vascular_smooth0.71037323
106MP0003943_abnormal_hepatobiliary_system0.70823292
107* MP0002115_abnormal_skeleton_extremities0.70626919
108MP0001175_abnormal_lung_morphology0.70123008
109MP0004147_increased_porphyrin_level0.68163420
110* MP0001784_abnormal_fluid_regulation0.67743229
111MP0005171_absent_coat_pigmentation0.67484357
112MP0002932_abnormal_joint_morphology0.67257993
113MP0001243_abnormal_dermal_layer0.67111381
114MP0002332_abnormal_exercise_endurance0.66089659
115MP0004085_abnormal_heartbeat0.66061493
116MP0002009_preneoplasia0.65011778
117MP0010352_gastrointestinal_tract_polyps0.63030376
118MP0008007_abnormal_cellular_replicative0.60808340
119MP0002254_reproductive_system_inflammat0.60770013
120MP0002796_impaired_skin_barrier0.60381838
121* MP0000163_abnormal_cartilage_morphology0.60094709
122MP0001915_intracranial_hemorrhage0.58325971
123MP0005084_abnormal_gallbladder_morpholo0.56563548
124MP0001849_ear_inflammation0.55985379
125MP0001614_abnormal_blood_vessel0.55968456
126MP0005409_darkened_coat_color0.55876303
127MP0000749_muscle_degeneration0.55311789
128MP0005365_abnormal_bile_salt0.54934097
129* MP0002113_abnormal_skeleton_development0.54897416
130MP0000733_abnormal_muscle_development0.54760636
131MP0002877_abnormal_melanocyte_morpholog0.54350699
132MP0008961_abnormal_basal_metabolism0.53683977
133MP0001299_abnormal_eye_distance/0.53376357
134MP0004484_altered_response_of0.53266498
135MP0000858_altered_metastatic_potential0.52398936
136MP0000249_abnormal_blood_vessel0.52354996
137MP0002896_abnormal_bone_mineralization0.50415389
138* MP0002128_abnormal_blood_circulation0.50023844
139MP0002638_abnormal_pupillary_reflex0.49930339
140MP0005076_abnormal_cell_differentiation0.48690870
141MP0003646_muscle_fatigue0.47368468
142MP0005369_muscle_phenotype0.46740388
143MP0005508_abnormal_skeleton_morphology0.46135868
144MP0009672_abnormal_birth_weight0.45712038

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)7.05844760
2Acanthosis nigricans (HP:0000956)6.40063166
3Hypertriglyceridemia (HP:0002155)5.06300603
4Premature rupture of membranes (HP:0001788)4.40369089
5Increased connective tissue (HP:0009025)3.94439554
6Cerebral aneurysm (HP:0004944)3.81896574
7Hyperglycinuria (HP:0003108)3.80683905
8Protrusio acetabuli (HP:0003179)3.78122993
9Insulin-resistant diabetes mellitus (HP:0000831)3.70001370
10Broad metatarsal (HP:0001783)3.63878367
11Ankle contracture (HP:0006466)3.59337957
12Difficulty running (HP:0009046)3.54589329
13Atrioventricular block (HP:0001678)3.50640986
14Broad ribs (HP:0000885)3.34290296
15Spondylolisthesis (HP:0003302)3.28589043
16Long foot (HP:0001833)3.28217815
17Aortic dissection (HP:0002647)3.27067590
18Pigmentary retinal degeneration (HP:0001146)3.25748256
19Shallow orbits (HP:0000586)3.20071423
20Aortic aneurysm (HP:0004942)3.17459770
21Acute lymphatic leukemia (HP:0006721)3.13396614
22Myoglobinuria (HP:0002913)3.08751772
23Abnormality of glycine metabolism (HP:0010895)3.07771520
24Abnormality of serine family amino acid metabolism (HP:0010894)3.07771520
25Mesangial abnormality (HP:0001966)3.05549878
26Muscle fiber splitting (HP:0003555)3.00888020
27Reduced subcutaneous adipose tissue (HP:0003758)3.00430235
28Wormian bones (HP:0002645)3.00141937
29Bone cyst (HP:0012062)2.97813178
30Hemorrhage of the eye (HP:0011885)2.96708269
31Aortic regurgitation (HP:0001659)2.95951844
32Hyperthyroidism (HP:0000836)2.95803838
33Increased variability in muscle fiber diameter (HP:0003557)2.94202827
34Abnormality of proline metabolism (HP:0010907)2.93995640
35Hydroxyprolinuria (HP:0003080)2.93995640
36Vascular tortuosity (HP:0004948)2.92720749
37Subcapsular cataract (HP:0000523)2.92408079
38Growth hormone excess (HP:0000845)2.90661394
39Joint stiffness (HP:0001387)2.89200831
40Spinal rigidity (HP:0003306)2.86976177
41Type 1 muscle fiber predominance (HP:0003803)2.85587818
42Insulin resistance (HP:0000855)2.81133966
43Lipoatrophy (HP:0100578)2.81004731
44Mitral valve prolapse (HP:0001634)2.71271031
45Soft skin (HP:0000977)2.69978003
46Dilatation of the ascending aorta (HP:0005111)2.66743238
47Arterial tortuosity (HP:0005116)2.63089798
48Lymphangioma (HP:0100764)2.61998276
49Myocardial infarction (HP:0001658)2.59419359
50Relative macrocephaly (HP:0004482)2.57393157
51Hypoalphalipoproteinemia (HP:0003233)2.56956691
52Venous abnormality (HP:0002624)2.56524364
53Genu recurvatum (HP:0002816)2.55292651
54Large hands (HP:0001176)2.54015164
55Hyporeflexia of lower limbs (HP:0002600)2.52489810
56Hematochezia (HP:0002573)2.51350022
57Distal arthrogryposis (HP:0005684)2.50799478
58Abnormality of skeletal muscle fiber size (HP:0012084)2.49845778
59Acute myeloid leukemia (HP:0004808)2.49094863
60Biconcave vertebral bodies (HP:0004586)2.45168937
61Infantile muscular hypotonia (HP:0008947)2.42832120
62Joint laxity (HP:0001388)2.41625419
63Atrophic scars (HP:0001075)2.41075142
64Abnormality of fatty-acid metabolism (HP:0004359)2.37680655
65Facial diplegia (HP:0001349)2.37674629
66Rectal prolapse (HP:0002035)2.36431877
67Complement deficiency (HP:0004431)2.35873668
68Venous insufficiency (HP:0005293)2.35382999
69Abnormality of dentin (HP:0010299)2.35224130
70Multiple enchondromatosis (HP:0005701)2.35177192
71Aneurysm (HP:0002617)2.34916761
72Round ear (HP:0100830)2.34686595
73Hypokalemic alkalosis (HP:0001949)2.34461307
74Right ventricular cardiomyopathy (HP:0011663)2.33565240
75Hypoplasia of the iris (HP:0007676)2.31966890
76Hypoglycemic coma (HP:0001325)2.30534724
77Follicular hyperkeratosis (HP:0007502)2.30298162
78Rhabdomyolysis (HP:0003201)2.30144577
79Ketoacidosis (HP:0001993)2.29243630
80Buphthalmos (HP:0000557)2.27297105
81Scapular winging (HP:0003691)2.27090201
82Metaphyseal dysplasia (HP:0100255)2.26499939
83Spinal cord lesions (HP:0100561)2.26106443
84Syringomyelia (HP:0003396)2.26106443
85Heart block (HP:0012722)2.24421769
86Abnormal atrioventricular conduction (HP:0005150)2.22934946
87Abnormality of the acetabulum (HP:0003170)2.22167426
88Abnormal cartilage morphology (HP:0002763)2.22161107
89Thoracolumbar scoliosis (HP:0002944)2.21686524
90Redundant skin (HP:0001582)2.18951206
91Fragile skin (HP:0001030)2.18587011
92Type 2 muscle fiber atrophy (HP:0003554)2.18383913
93Polar cataract (HP:0010696)2.17990913
94Hyperpituitarism (HP:0010514)2.15376926
95Abnormality of skull ossification (HP:0002703)2.15340845
96Accelerated skeletal maturation (HP:0005616)2.14809535
97Panhypogammaglobulinemia (HP:0003139)2.14752946
98Prominent supraorbital ridges (HP:0000336)2.13549290
99Skin nodule (HP:0200036)2.12001621
100Abnormal delivery (HP:0001787)2.11789531
101Epidermoid cyst (HP:0200040)2.11644706
102Ectopia lentis (HP:0001083)2.11616155
103Wide anterior fontanel (HP:0000260)2.11287539
104Decreased skull ossification (HP:0004331)2.10868169
105Thyroid-stimulating hormone excess (HP:0002925)2.10528516
106Focal segmental glomerulosclerosis (HP:0000097)2.10476486
107Abnormality of the right ventricle (HP:0001707)2.09508340
108Elbow flexion contracture (HP:0002987)2.09135985
109Striae distensae (HP:0001065)2.07155548
110Proximal amyotrophy (HP:0007126)2.06446256
111Ovoid vertebral bodies (HP:0003300)2.04999406
112Peritonitis (HP:0002586)2.04980108
113Spinal canal stenosis (HP:0003416)2.04752291
114Osteolytic defects of the phalanges of the hand (HP:0009771)2.04663225
115Osteolytic defects of the hand bones (HP:0009699)2.04663225
116Mucopolysacchariduria (HP:0008155)2.03597889
117Urinary glycosaminoglycan excretion (HP:0003541)2.03597889
118Increased corneal curvature (HP:0100692)2.02879433
119Keratoconus (HP:0000563)2.02879433
120Bladder diverticulum (HP:0000015)2.02467732
121Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01032702
122Breech presentation (HP:0001623)2.00802599
123Blue sclerae (HP:0000592)2.00741663
124Nephritis (HP:0000123)2.00138248
125Vertebral compression fractures (HP:0002953)1.99975753
126Ketosis (HP:0001946)1.99536200
127Aortic valve stenosis (HP:0001650)1.98759583
128Enlarged penis (HP:0000040)1.98429443
129Congenital hip dislocation (HP:0001374)1.97900576
130Delayed closure of the anterior fontanelle (HP:0001476)1.97140687
131Tetraparesis (HP:0002273)1.97023212
132Flared iliac wings (HP:0002869)1.95056495
133Cupped ribs (HP:0000887)1.94604215
134Neonatal short-limb short stature (HP:0008921)1.94386198
135Prolonged bleeding time (HP:0003010)1.93841176
136Testicular atrophy (HP:0000029)1.91847372
137Decreased subcutaneous fat (HP:0001002)1.91752753
138Abnormal eating behavior (HP:0100738)1.91606738
139Muscle fiber atrophy (HP:0100295)1.91538817
140Morphological abnormality of the middle ear (HP:0008609)1.89984875
141Glucose intolerance (HP:0000833)1.89861726
142Overgrowth (HP:0001548)1.89024525
143Absent frontal sinuses (HP:0002688)1.87145222
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86149509
145Abnormality of polysaccharide metabolism (HP:0011012)1.86149509
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86149509
147Turricephaly (HP:0000262)1.86145565
148Mitral regurgitation (HP:0001653)1.85863303
149Hyperextensible skin (HP:0000974)1.85483547
150Mesomelia (HP:0003027)1.85275941
151Abnormality of the 4th metacarpal (HP:0010012)1.84077950
152Abnormality of the intrinsic pathway (HP:0010989)1.84039569
153Bowel diverticulosis (HP:0005222)1.83889596
154Knee flexion contracture (HP:0006380)1.83468926
155Abnormal albumin level (HP:0012116)1.81623818
156Hypoalbuminemia (HP:0003073)1.81623818
157Renal salt wasting (HP:0000127)1.80844124
158Cervical subluxation (HP:0003308)1.80677674
159Premature skin wrinkling (HP:0100678)1.80417607
160Abnormality of the costochondral junction (HP:0000919)1.80092143
161Bulbous nose (HP:0000414)1.79833715
162Resting tremor (HP:0002322)1.78597762
163Calcaneovalgus deformity (HP:0001848)1.76870992
164Abnormal hemoglobin (HP:0011902)1.76296350
165Hyperglycemia (HP:0003074)1.75731085
166Deformed tarsal bones (HP:0008119)1.75456816
167Myotonia (HP:0002486)1.75035067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D5.38094695
2TRIB35.09979519
3SIK14.05984270
4KIT3.92800377
5CAMK1G3.89866176
6RIPK12.79551218
7BCKDK2.70894726
8TAOK32.64605431
9LMTK22.61181450
10TIE12.40694977
11TEC2.36866197
12PDK42.35733789
13PDK32.35733789
14PDGFRA2.27103222
15FRK2.21780303
16PIK3CG2.19397229
17DDR22.14940662
18FGFR22.14323615
19EPHB22.13872566
20TTN2.11605258
21FES2.04136125
22LATS12.01625033
23FGFR31.86261920
24MST1R1.85663739
25MAP2K31.83982922
26PIK3CA1.78931053
27TGFBR21.68814399
28RPS6KB21.66145490
29PDK21.63638279
30PRKAA21.55109350
31INSRR1.53622989
32MKNK11.44991099
33FER1.39262962
34EEF2K1.36502649
35MAP4K21.34911516
36PRKD31.33254081
37MYLK1.28819338
38SYK1.28699866
39NEK91.28022674
40MAPK71.26976186
41PBK1.25913627
42CDK61.22238691
43MET1.19468106
44JAK11.18798752
45BRSK21.10121442
46MAPKAPK51.08486351
47PTK2B1.07827814
48TBK11.07097537
49LATS21.06590571
50CDK91.04486965
51ERN11.04022345
52PHKG21.01602177
53PHKG11.01602177
54PDGFRB1.01447819
55CCNB11.01356480
56MAP2K10.99368014
57PRKCH0.99180654
58BLK0.96791512
59BMPR20.96477791
60BTK0.86555636
61MTOR0.85557835
62PAK20.84360697
63PKN20.82297679
64RPS6KC10.82185757
65RPS6KL10.82185757
66MAPK40.81617226
67PDPK10.81272806
68AKT30.81219682
69ZAP700.80515616
70FGFR10.80427750
71RET0.79421208
72CAMKK20.78190339
73CDK80.76506924
74PRKAA10.76050324
75TRPM70.75562965
76PRPF4B0.75045996
77WNK10.73353255
78PRKD10.72295806
79RPS6KA60.72163512
80NUAK10.71566362
81FGFR40.71147038
82EIF2AK30.70874653
83IGF1R0.70592267
84NME20.69453771
85ITK0.69209221
86ILK0.68634909
87RPS6KA20.68606493
88HIPK20.68464592
89MAPK30.68404217
90EIF2AK20.67277319
91STK30.66968304
92PAK40.64751741
93MAP3K60.63359811
94KDR0.63345384
95MAP2K20.62509887
96INSR0.62001897
97GSK3A0.60222548
98ROCK10.59843758
99MAPKAPK30.59215667
100DMPK0.58176783
101BMPR1B0.57603559
102PAK30.56178617
103PDK10.55341852
104BMX0.54531798
105ADRBK10.54485926
106JAK20.53458552
107HCK0.52453147
108DAPK30.52061860
109DAPK20.51176464
110PTK60.50695888
111MAP3K140.50628559
112MARK20.49345259
113PRKACG0.48711497
114CDK30.47465607
115PRKD20.46999678
116RPS6KA50.46998513
117SRC0.44997870
118OBSCN0.44488053
119LCK0.43499802
120LRRK20.42636477
121MAPK10.41981874
122STK380.41226157
123CSF1R0.41140151
124CDK70.40678187
125EPHA30.39542880
126ADRBK20.37685530
127ABL20.36885664
128PRKG20.35931852
129MAPK120.35866963
130PTK20.35327292
131IKBKB0.34182808
132PINK10.34160839
133NTRK10.34131409
134RPS6KB10.33738661
135MAPK110.33718810
136CAMK10.32369367
137STK110.30039496
138TGFBR10.29299364
139CSK0.28745750
140CDK40.27145635
141PRKCE0.26911467
142MAP3K70.24871175
143ABL10.23991647
144SCYL20.23886574
145JAK30.21589196
146GRK50.21357532
147AKT10.20831958
148AKT20.20607421
149TYRO30.20523845
150STK38L0.20255938
151SGK30.19270860
152FLT30.18114005
153MAP3K20.15883552

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.88857739
2PPAR signaling pathway_Homo sapiens_hsa033204.27259198
3Fatty acid biosynthesis_Homo sapiens_hsa000614.21519973
4Propanoate metabolism_Homo sapiens_hsa006403.99358236
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.34755044
6Fatty acid metabolism_Homo sapiens_hsa012123.10017713
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.02545026
8Ovarian steroidogenesis_Homo sapiens_hsa049132.68514131
9Glycerolipid metabolism_Homo sapiens_hsa005612.68188980
10Fatty acid degradation_Homo sapiens_hsa000712.59780432
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.56254978
12Adipocytokine signaling pathway_Homo sapiens_hsa049202.33565820
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24323018
14AMPK signaling pathway_Homo sapiens_hsa041522.16632426
15ECM-receptor interaction_Homo sapiens_hsa045122.15646174
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.97047745
17Other glycan degradation_Homo sapiens_hsa005111.90846847
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.82707297
19Pyruvate metabolism_Homo sapiens_hsa006201.70264046
20Dorso-ventral axis formation_Homo sapiens_hsa043201.66287193
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61833206
22beta-Alanine metabolism_Homo sapiens_hsa004101.52427980
23Focal adhesion_Homo sapiens_hsa045101.51422912
24Asthma_Homo sapiens_hsa053101.51228525
25Fat digestion and absorption_Homo sapiens_hsa049751.47683808
26Caffeine metabolism_Homo sapiens_hsa002321.42352014
27Insulin resistance_Homo sapiens_hsa049311.40085936
28Carbon metabolism_Homo sapiens_hsa012001.36272669
29Insulin signaling pathway_Homo sapiens_hsa049101.34202996
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.31866507
31Protein digestion and absorption_Homo sapiens_hsa049741.25319352
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22968435
33Chronic myeloid leukemia_Homo sapiens_hsa052201.22012311
34Peroxisome_Homo sapiens_hsa041461.19163314
35Renin secretion_Homo sapiens_hsa049241.14721589
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13002025
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11895275
38Arachidonic acid metabolism_Homo sapiens_hsa005901.09141018
39Vitamin B6 metabolism_Homo sapiens_hsa007501.05697339
40Systemic lupus erythematosus_Homo sapiens_hsa053221.03813248
41Glucagon signaling pathway_Homo sapiens_hsa049221.02430271
42Nitrogen metabolism_Homo sapiens_hsa009101.01995638
43Small cell lung cancer_Homo sapiens_hsa052221.01677868
44Dilated cardiomyopathy_Homo sapiens_hsa054140.97527035
45N-Glycan biosynthesis_Homo sapiens_hsa005100.94888236
46Leishmaniasis_Homo sapiens_hsa051400.94773050
47Butanoate metabolism_Homo sapiens_hsa006500.92485808
48Amoebiasis_Homo sapiens_hsa051460.89728511
49Proteoglycans in cancer_Homo sapiens_hsa052050.86748188
50Phenylalanine metabolism_Homo sapiens_hsa003600.85846829
51Olfactory transduction_Homo sapiens_hsa047400.84397337
52Chemical carcinogenesis_Homo sapiens_hsa052040.84147272
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83845396
54Long-term depression_Homo sapiens_hsa047300.82416668
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81776465
56Selenocompound metabolism_Homo sapiens_hsa004500.81473123
57Hematopoietic cell lineage_Homo sapiens_hsa046400.81234125
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.80872643
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80767525
60One carbon pool by folate_Homo sapiens_hsa006700.80145886
61Type II diabetes mellitus_Homo sapiens_hsa049300.79761182
62Adherens junction_Homo sapiens_hsa045200.79513342
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77098074
64Tyrosine metabolism_Homo sapiens_hsa003500.76706597
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76324174
66Renin-angiotensin system_Homo sapiens_hsa046140.75463217
67Viral myocarditis_Homo sapiens_hsa054160.73968653
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71346061
69mTOR signaling pathway_Homo sapiens_hsa041500.70731496
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68423934
71African trypanosomiasis_Homo sapiens_hsa051430.68212060
72Fatty acid elongation_Homo sapiens_hsa000620.67838160
73Oxytocin signaling pathway_Homo sapiens_hsa049210.67712768
74Gap junction_Homo sapiens_hsa045400.67664288
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.66902873
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.66506065
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66174378
78Ribosome_Homo sapiens_hsa030100.65068988
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64116207
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63460773
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62023061
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59504696
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59051409
84Calcium signaling pathway_Homo sapiens_hsa040200.58644256
85Tryptophan metabolism_Homo sapiens_hsa003800.57608002
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.57388340
87Purine metabolism_Homo sapiens_hsa002300.56583257
88Allograft rejection_Homo sapiens_hsa053300.54998707
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53731327
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53688825
91Platelet activation_Homo sapiens_hsa046110.51855680
92HIF-1 signaling pathway_Homo sapiens_hsa040660.51807272
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51718724
94Staphylococcus aureus infection_Homo sapiens_hsa051500.50649411
95TGF-beta signaling pathway_Homo sapiens_hsa043500.50550433
96Pancreatic secretion_Homo sapiens_hsa049720.49289478
97cAMP signaling pathway_Homo sapiens_hsa040240.48563250
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48199289
99Tight junction_Homo sapiens_hsa045300.47613385
100Ras signaling pathway_Homo sapiens_hsa040140.46682430
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43815035
102Lysine degradation_Homo sapiens_hsa003100.43807155
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.43515869
104Melanoma_Homo sapiens_hsa052180.42616311
105MAPK signaling pathway_Homo sapiens_hsa040100.42430737
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41999064
107ABC transporters_Homo sapiens_hsa020100.41667967
108Rap1 signaling pathway_Homo sapiens_hsa040150.40750106
109Prolactin signaling pathway_Homo sapiens_hsa049170.40300184
110Pentose phosphate pathway_Homo sapiens_hsa000300.38201633
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37999620
112Sulfur metabolism_Homo sapiens_hsa009200.37617154
113Malaria_Homo sapiens_hsa051440.37444041
114Complement and coagulation cascades_Homo sapiens_hsa046100.36252603
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36103509
116HTLV-I infection_Homo sapiens_hsa051660.36001658
117Toxoplasmosis_Homo sapiens_hsa051450.35347259
118Glutathione metabolism_Homo sapiens_hsa004800.35127499
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35064454
120Pathways in cancer_Homo sapiens_hsa052000.34779507
121Starch and sucrose metabolism_Homo sapiens_hsa005000.33857227
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.33753284
123Influenza A_Homo sapiens_hsa051640.33188417
124Autoimmune thyroid disease_Homo sapiens_hsa053200.32552304
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32057773
126Thyroid hormone synthesis_Homo sapiens_hsa049180.31928199
127Hippo signaling pathway_Homo sapiens_hsa043900.31432840
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31134918
129Basal cell carcinoma_Homo sapiens_hsa052170.30956810
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.29936778
131Glioma_Homo sapiens_hsa052140.29002795
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28561104
133Salivary secretion_Homo sapiens_hsa049700.27826792
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26738512
135Acute myeloid leukemia_Homo sapiens_hsa052210.26222282
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26082368
137Axon guidance_Homo sapiens_hsa043600.25988771
138FoxO signaling pathway_Homo sapiens_hsa040680.25631929
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25609288
140Renal cell carcinoma_Homo sapiens_hsa052110.24477650
141Melanogenesis_Homo sapiens_hsa049160.23474720
142Pancreatic cancer_Homo sapiens_hsa052120.23061818
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22921182
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.22441635
145Estrogen signaling pathway_Homo sapiens_hsa049150.21928270
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21701013
147Arginine biosynthesis_Homo sapiens_hsa002200.19589169
148Endometrial cancer_Homo sapiens_hsa052130.19435515
149VEGF signaling pathway_Homo sapiens_hsa043700.19150852

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