NPRL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The function of the encoded protein is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)6.30402444
2gas transport (GO:0015669)5.30926198
3modulation by virus of host process (GO:0019054)5.06711484
4negative regulation of erythrocyte differentiation (GO:0045647)4.96787826
5protoporphyrinogen IX metabolic process (GO:0046501)4.90334041
6negative regulation of phagocytosis (GO:0050765)4.64857092
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.62394046
8negative regulation of cell killing (GO:0031342)4.62394046
9erythrocyte maturation (GO:0043249)4.46957670
10presynaptic membrane assembly (GO:0097105)4.43376706
11neuron cell-cell adhesion (GO:0007158)4.37776641
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.29525008
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.29525008
14modulation by symbiont of host immune response (GO:0052553)4.29525008
15positive regulation by symbiont of host defense response (GO:0052509)4.29525008
16modulation by symbiont of host defense response (GO:0052031)4.29525008
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.29525008
18protein complex biogenesis (GO:0070271)4.29239336
19modulation by symbiont of host cellular process (GO:0044068)4.26327497
20presynaptic membrane organization (GO:0097090)4.23070333
21neutrophil activation involved in immune response (GO:0002283)4.10601178
22postsynaptic membrane organization (GO:0001941)4.08623054
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.07824629
24hemoglobin metabolic process (GO:0020027)4.05212802
25cellular response to virus (GO:0098586)4.03693375
26megakaryocyte development (GO:0035855)3.93720982
27GDP-mannose metabolic process (GO:0019673)3.88143433
28positive regulation of histone deacetylation (GO:0031065)3.85762758
29antigen processing and presentation of endogenous antigen (GO:0019883)3.79635892
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.77291151
31protoporphyrinogen IX biosynthetic process (GO:0006782)3.74548194
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.71984154
33NADH dehydrogenase complex assembly (GO:0010257)3.71984154
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71984154
35regulation of mast cell degranulation (GO:0043304)3.70537600
36positive regulation of gamma-delta T cell activation (GO:0046645)3.66943348
37response to pheromone (GO:0019236)3.65788978
38mitochondrial respiratory chain complex assembly (GO:0033108)3.59476975
39positive regulation of action potential (GO:0045760)3.58715021
403-UTR-mediated mRNA stabilization (GO:0070935)3.58373945
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55162136
42cAMP catabolic process (GO:0006198)3.54530452
43leukocyte aggregation (GO:0070486)3.54418707
44erythrocyte development (GO:0048821)3.54374793
45nucleotide transmembrane transport (GO:1901679)3.53643559
46heme biosynthetic process (GO:0006783)3.52726275
47regulation of chromatin binding (GO:0035561)3.51502393
48mannose metabolic process (GO:0006013)3.50574665
49cyclic nucleotide catabolic process (GO:0009214)3.47618350
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47508561
51positive regulation of protein homodimerization activity (GO:0090073)3.46905759
52polyol transport (GO:0015791)3.44529016
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43213663
54myeloid cell development (GO:0061515)3.41518276
55regulation of platelet aggregation (GO:0090330)3.40842925
56regulation of B cell receptor signaling pathway (GO:0050855)3.35918297
57tolerance induction (GO:0002507)3.34555295
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33992455
59mesenchymal cell differentiation involved in kidney development (GO:0072161)3.33404407
60mesenchymal cell differentiation involved in renal system development (GO:2001012)3.33404407
61positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32790536
62intracellular estrogen receptor signaling pathway (GO:0030520)3.32424273
63positive thymic T cell selection (GO:0045059)3.31667808
64regulation of somitogenesis (GO:0014807)3.29872668
65positive regulation of uterine smooth muscle contraction (GO:0070474)3.28996097
66regulation of hydrogen peroxide metabolic process (GO:0010310)3.28815734
67negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28788038
68porphyrin-containing compound biosynthetic process (GO:0006779)3.28323795
69regulation of relaxation of muscle (GO:1901077)3.21771402
70regulation of mast cell activation involved in immune response (GO:0033006)3.19216071
71regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19036049
72thymic T cell selection (GO:0045061)3.18916318
73chaperone-mediated protein transport (GO:0072321)3.16477676
74regulation of respiratory system process (GO:0044065)3.11429821
75signal complex assembly (GO:0007172)3.09997748
76response to peptidoglycan (GO:0032494)3.09702036
77axon ensheathment in central nervous system (GO:0032291)3.08568951
78central nervous system myelination (GO:0022010)3.08568951
79detection of bacterium (GO:0016045)3.07697993
80behavioral response to pain (GO:0048266)3.07004994
81acrosome reaction (GO:0007340)3.05859503
82platelet formation (GO:0030220)3.03586837
83positive regulation of fibroblast migration (GO:0010763)3.02183067
84regulation of leukocyte degranulation (GO:0043300)3.01826234
85adenosine receptor signaling pathway (GO:0001973)3.01492320
86tetrapyrrole biosynthetic process (GO:0033014)3.00744409
87regulation of respiratory gaseous exchange (GO:0043576)2.96838622
88cellular response to interleukin-15 (GO:0071350)2.95816825
89modulation by virus of host morphology or physiology (GO:0019048)2.94157587
90positive regulation of synapse assembly (GO:0051965)2.93691150
91regulation of response to osmotic stress (GO:0047484)2.93585512
92negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92206061
93protein localization to synapse (GO:0035418)2.91863143
94leukocyte migration involved in inflammatory response (GO:0002523)2.90449695
95negative regulation of leukocyte mediated immunity (GO:0002704)2.89722085
96detection of other organism (GO:0098543)2.87199780
97positive regulation of protein deacetylation (GO:0090312)2.86141807
98negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.85351587
99cell differentiation involved in metanephros development (GO:0072202)2.85048551
100positive regulation of meiosis (GO:0045836)2.84885346
101granulocyte differentiation (GO:0030851)2.84417141
102regulation of timing of cell differentiation (GO:0048505)2.83491861
103cilium or flagellum-dependent cell motility (GO:0001539)2.83239730
104daunorubicin metabolic process (GO:0044597)2.82831990
105polyketide metabolic process (GO:0030638)2.82831990
106doxorubicin metabolic process (GO:0044598)2.82831990
107regulation of gamma-delta T cell differentiation (GO:0045586)2.82759914
108peripheral nervous system neuron development (GO:0048935)2.81370973
109response to interleukin-15 (GO:0070672)2.80786245
110deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.80580894
111regulation of gamma-delta T cell activation (GO:0046643)2.79872366
112leukocyte degranulation (GO:0043299)2.79270288
113negative regulation of lymphocyte mediated immunity (GO:0002707)2.78688794
114response to methylmercury (GO:0051597)2.78216569
115neutrophil activation (GO:0042119)2.75719120
116startle response (GO:0001964)2.75598661
117protein neddylation (GO:0045116)2.75152055
118sleep (GO:0030431)2.75090685
119macrophage activation involved in immune response (GO:0002281)2.73543887
120deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.72697690
121urinary tract smooth muscle contraction (GO:0014848)2.72611725
122regulation of early endosome to late endosome transport (GO:2000641)2.71645419
123response to host immune response (GO:0052572)2.71113840
124response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.71113840
125ribosomal small subunit biogenesis (GO:0042274)2.70232680
126granulocyte activation (GO:0036230)2.69988786
127positive regulation of granulocyte differentiation (GO:0030854)2.69932934
128mannosylation (GO:0097502)2.69878115
129protein prenylation (GO:0018342)2.69182578
130prenylation (GO:0097354)2.69182578
131regulation of uterine smooth muscle contraction (GO:0070472)2.69017516
132neuronal action potential propagation (GO:0019227)2.68663167
133negative regulation of myoblast differentiation (GO:0045662)2.68267289
134porphyrin-containing compound metabolic process (GO:0006778)2.67998979
135intraciliary transport (GO:0042073)2.67745913
136regulation of synaptic transmission, GABAergic (GO:0032228)2.67282125
137negative regulation of cAMP-mediated signaling (GO:0043951)2.66731076
138negative regulation of heart rate (GO:0010459)2.65776621
139positive regulation of amino acid transport (GO:0051957)2.64747113
140negative regulation of glial cell proliferation (GO:0060253)2.64492288
141antigen processing and presentation via MHC class Ib (GO:0002475)2.64005078
142aggressive behavior (GO:0002118)2.63591895
143regulation of action potential (GO:0098900)2.63051983
144apoptotic process involved in morphogenesis (GO:0060561)2.63008477
145heme metabolic process (GO:0042168)2.62120658
146pentose-phosphate shunt (GO:0006098)2.61981310
147autophagic vacuole fusion (GO:0000046)2.61737940
148activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.61709147
149response to host (GO:0075136)2.61662639
150response to host defenses (GO:0052200)2.61662639
151response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.61662639
152viral protein processing (GO:0019082)2.61483414
153mechanosensory behavior (GO:0007638)2.60340900
154protein targeting to plasma membrane (GO:0072661)2.59479701
155regulation of dopamine metabolic process (GO:0042053)2.58495962
156regulation of catecholamine metabolic process (GO:0042069)2.58495962
157nucleotide transport (GO:0006862)2.58377551
158positive regulation of peptidyl-lysine acetylation (GO:2000758)2.57777703
159positive regulation of protein acetylation (GO:1901985)2.57777703
160protein insertion into membrane (GO:0051205)2.56688006
161purine ribonucleotide transport (GO:0015868)2.56441177
162fatty acid elongation (GO:0030497)2.55409592
163regulation of mitochondrial translation (GO:0070129)2.55224901
164regulation of regulated secretory pathway (GO:1903305)2.53932119
165pentose metabolic process (GO:0019321)2.53807554
166T cell selection (GO:0045058)2.52743435
167myeloid cell activation involved in immune response (GO:0002275)2.51716175
168regulation of defense response to virus by virus (GO:0050690)2.51675005
169regulation of cell communication by electrical coupling (GO:0010649)2.50902997
170neurotransmitter uptake (GO:0001504)2.49684796
171dopaminergic neuron differentiation (GO:0071542)2.48933108
172nonmotile primary cilium assembly (GO:0035058)2.48522304
173positive regulation of meiotic cell cycle (GO:0051446)2.47832747
174one-carbon compound transport (GO:0019755)2.47109880
175adenine nucleotide transport (GO:0051503)2.46961621
176respiratory electron transport chain (GO:0022904)2.46606360
177regulation of synapse assembly (GO:0051963)2.46076565
178regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.45730123
179regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.44600003
180amino acid import (GO:0043090)2.44367268
181GPI anchor metabolic process (GO:0006505)2.43799131
182peroxisome fission (GO:0016559)2.43678157
183retinal ganglion cell axon guidance (GO:0031290)2.43326093
184calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43250087
185transmission of nerve impulse (GO:0019226)2.42069309
186isoprenoid biosynthetic process (GO:0008299)2.40739154
187tRNA methylation (GO:0030488)2.40086857
188electron transport chain (GO:0022900)2.39033989
189regulation of chemokine-mediated signaling pathway (GO:0070099)2.38818400
190metallo-sulfur cluster assembly (GO:0031163)2.37925473
191iron-sulfur cluster assembly (GO:0016226)2.37925473
192L-amino acid import (GO:0043092)2.37861691
193regulation of mitochondrial fission (GO:0090140)2.37855420
194long-chain fatty acid biosynthetic process (GO:0042759)2.37070362
195negative regulation of protein localization to cell surface (GO:2000009)2.34192796
196nucleoside diphosphate catabolic process (GO:0009134)2.33800644
197cornea development in camera-type eye (GO:0061303)2.33388817
198regulation of development, heterochronic (GO:0040034)2.30948027
199glucosamine-containing compound catabolic process (GO:1901072)2.27956961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.74427839
2EZH2_22144423_ChIP-Seq_EOC_Human3.68590489
3VDR_21846776_ChIP-Seq_THP-1_Human3.32382403
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19146288
5TAF15_26573619_Chip-Seq_HEK293_Human3.14947622
6MYC_22102868_ChIP-Seq_BL_Human3.06203577
7LXR_22292898_ChIP-Seq_THP-1_Human2.83833099
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73469561
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.69895108
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.56035294
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54118799
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51084863
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.41567732
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.39527023
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34505362
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33235019
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.31560278
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.30831984
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28101368
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26233501
21KDM2B_26808549_Chip-Seq_DND41_Human2.25190884
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24154675
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18284945
24TCF7_22412390_ChIP-Seq_EML_Mouse2.13766086
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13158068
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12985377
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.10652569
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08868475
29IGF1R_20145208_ChIP-Seq_DFB_Human2.07761470
30RACK7_27058665_Chip-Seq_MCF-7_Human2.05590040
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05341015
32P68_20966046_ChIP-Seq_HELA_Human2.05196087
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04564242
34CBX2_27304074_Chip-Seq_ESCs_Mouse2.00931961
35VDR_22108803_ChIP-Seq_LS180_Human1.98340640
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97236590
37VDR_24763502_ChIP-Seq_THP-1_Human1.96423779
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96353103
39MAF_26560356_Chip-Seq_TH1_Human1.95879505
40SCL_19346495_ChIP-Seq_HPC-7_Human1.95318606
41MAF_26560356_Chip-Seq_TH2_Human1.89840040
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87006307
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86552952
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85985302
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85985302
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85350469
47GATA1_19941826_ChIP-Seq_K562_Human1.84408152
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.84047813
49UTX_26944678_Chip-Seq_JUKART_Human1.81841718
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80570178
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80142988
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79650899
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78388977
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.78101724
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73721149
56P300_19829295_ChIP-Seq_ESCs_Human1.72991804
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71884153
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71861747
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71573625
60AR_21572438_ChIP-Seq_LNCaP_Human1.70843573
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70138562
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69337740
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.69301846
64BCL6_27268052_Chip-Seq_Bcells_Human1.69067701
65* RUNX1_22412390_ChIP-Seq_EML_Mouse1.68933459
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68923374
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68520939
68* NCOR1_26117541_ChIP-Seq_K562_Human1.68162983
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.67889000
70REST_21632747_ChIP-Seq_MESCs_Mouse1.66816915
71RNF2_27304074_Chip-Seq_NSC_Mouse1.64746089
72BCOR_27268052_Chip-Seq_Bcells_Human1.62825982
73IRF1_19129219_ChIP-ChIP_H3396_Human1.61509023
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61500154
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61489276
76KDM2B_26808549_Chip-Seq_K562_Human1.61407095
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.60775913
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.59976730
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.58849401
80* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.58654225
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54858334
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54503500
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53497106
84* SMC4_20622854_ChIP-Seq_HELA_Human1.52760437
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49508867
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46528688
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.46341666
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45087474
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44717575
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44696364
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.40471013
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.40255822
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39863517
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39605620
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38623861
96DROSHA_22980978_ChIP-Seq_HELA_Human1.37454754
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37289672
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36805752
99SPI1_23127762_ChIP-Seq_K562_Human1.36643679
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35572909
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33722816
102SMAD4_21799915_ChIP-Seq_A2780_Human1.33243770
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33117494
104FUS_26573619_Chip-Seq_HEK293_Human1.32819821
105CREB1_26743006_Chip-Seq_LNCaP_Human1.31870871
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.31383756
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31048295
108HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31031766
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30923671
110POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30587232
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30093935
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29808837
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29198036
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27665023
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27560157
116SRF_21415370_ChIP-Seq_HL-1_Mouse1.26954795
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26781874
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26543602
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26390103
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26210605
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25836132
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25461591
123PHF8_20622854_ChIP-Seq_HELA_Human1.25099568
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24794073
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24761888
126E2F1_20622854_ChIP-Seq_HELA_Human1.24667204
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24600864
128P53_22387025_ChIP-Seq_ESCs_Mouse1.24434501
129CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23437334
130CTCF_21964334_Chip-Seq_Bcells_Human1.23278155
131REST_18959480_ChIP-ChIP_MESCs_Mouse1.22466671
132* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22088072
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20692214
134IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20436323
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20373068
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20172230
137EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19810957
138MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19786971
139STAT3_18555785_Chip-Seq_ESCs_Mouse1.19724746
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19122809
141CTCF_26484167_Chip-Seq_Bcells_Mouse1.19082031
142ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18900283
143SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18867291
144SMAD3_21741376_ChIP-Seq_EPCs_Human1.18271710
145SA1_27219007_Chip-Seq_Bcells_Human1.15402576
146CMYC_18555785_Chip-Seq_ESCs_Mouse1.15277211
147FLI1_27457419_Chip-Seq_LIVER_Mouse1.15097840
148P300_18555785_Chip-Seq_ESCs_Mouse1.14322803
149NMYC_18555785_Chip-Seq_ESCs_Mouse1.13666949
150SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13423685
151YY1_22570637_ChIP-Seq_MALME-3M_Human1.12934987
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11676671
153XRN2_22483619_ChIP-Seq_HELA_Human1.11586823
154ER_23166858_ChIP-Seq_MCF-7_Human1.11434126
155TAL1_26923725_Chip-Seq_HPCs_Mouse1.10852747
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10719306
157SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10356369
158LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10034689
159CTCF_27219007_Chip-Seq_Bcells_Human1.09931114
160JUN_21703547_ChIP-Seq_K562_Human1.09852124
161ZNF263_19887448_ChIP-Seq_K562_Human1.09741489
162TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09610930
163SPI1_23547873_ChIP-Seq_NB4_Human1.09395942
164SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09058727
165STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07907807
166PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07533287
167UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07218288
168SOX9_26525672_Chip-Seq_HEART_Mouse1.06601245
169FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05385844
170RING1B_27294783_Chip-Seq_ESCs_Mouse1.05172980
171SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05032613
172KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04997266
173* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04891290
174THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04833375
175SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04080425
176* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03911237
177CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03183043
178LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02560187
179SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02432499
180MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02349451
181POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02041168
182TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02041168
183RARB_24833708_ChIP-Seq_LIVER_Mouse1.01699333
184CTCF_20526341_ChIP-Seq_ESCs_Human1.01103425
185MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01044855
186GATA2_19941826_ChIP-Seq_K562_Human1.00467956
187CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00382363
188FOXP1_21924763_ChIP-Seq_HESCs_Human1.00171637
189SOX2_18555785_Chip-Seq_ESCs_Mouse0.99716657
190KDM2B_26808549_Chip-Seq_REH_Human0.99334757
191TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99068328
192E2F1_18555785_Chip-Seq_ESCs_Mouse0.98901219
193IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98600515
194RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98525678
195ZFX_18555785_Chip-Seq_ESCs_Mouse0.96841362
196PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96564899
197PU1_27457419_Chip-Seq_LIVER_Mouse0.95950701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after3.79381065
2MP0005083_abnormal_biliary_tract3.70704005
3MP0003880_abnormal_central_pattern3.59115721
4MP0003136_yellow_coat_color3.55546841
5MP0008260_abnormal_autophagy3.40399079
6MP0001968_abnormal_touch/_nociception3.36700895
7MP0001529_abnormal_vocalization3.31267144
8MP0003436_decreased_susceptibility_to3.24851472
9MP0005464_abnormal_platelet_physiology3.09033351
10MP0003303_peritoneal_inflammation3.07868017
11MP0005646_abnormal_pituitary_gland2.97403607
12MP0009278_abnormal_bone_marrow2.78616943
13MP0002735_abnormal_chemical_nociception2.70243368
14MP0005409_darkened_coat_color2.57554180
15MP0006276_abnormal_autonomic_nervous2.53028155
16MP0001188_hyperpigmentation2.41280510
17MP0003172_abnormal_lysosome_physiology2.39830654
18MP0003705_abnormal_hypodermis_morpholog2.28591775
19MP0005058_abnormal_lysosome_morphology2.25305545
20MP0009333_abnormal_splenocyte_physiolog2.17554474
21MP0000566_synostosis2.11263466
22MP0000685_abnormal_immune_system2.10327633
23MP0002163_abnormal_gland_morphology2.03849739
24MP0001545_abnormal_hematopoietic_system2.00985299
25MP0005397_hematopoietic_system_phenotyp2.00985299
26MP0004858_abnormal_nervous_system1.99086540
27MP0003763_abnormal_thymus_physiology1.97537371
28MP0002398_abnormal_bone_marrow1.96647807
29MP0005451_abnormal_body_composition1.96398238
30MP0005025_abnormal_response_to1.95449333
31MP0003724_increased_susceptibility_to1.94543120
32MP0005379_endocrine/exocrine_gland_phen1.93036971
33MP0002419_abnormal_innate_immunity1.90956491
34MP0001346_abnormal_lacrimal_gland1.90885646
35MP0006292_abnormal_olfactory_placode1.90761178
36MP0000372_irregular_coat_pigmentation1.88646803
37MP0000778_abnormal_nervous_system1.82967707
38MP0001905_abnormal_dopamine_level1.79636433
39MP0004859_abnormal_synaptic_plasticity1.79050570
40MP0004147_increased_porphyrin_level1.79041322
41MP0005645_abnormal_hypothalamus_physiol1.77603649
42MP0001486_abnormal_startle_reflex1.77027405
43MP0002249_abnormal_larynx_morphology1.76367004
44MP0005076_abnormal_cell_differentiation1.75253972
45MP0000703_abnormal_thymus_morphology1.74058986
46MP0003635_abnormal_synaptic_transmissio1.73355924
47MP0005670_abnormal_white_adipose1.71262406
48MP0002067_abnormal_sensory_capabilities1.71210460
49MP0005000_abnormal_immune_tolerance1.70680765
50MP0009379_abnormal_foot_pigmentation1.70171061
51MP0002420_abnormal_adaptive_immunity1.69351322
52MP0002272_abnormal_nervous_system1.68521883
53MP0004270_analgesia1.67248776
54MP0001819_abnormal_immune_cell1.66780615
55MP0002734_abnormal_mechanical_nocicepti1.64573541
56MP0004142_abnormal_muscle_tone1.63848098
57MP0003878_abnormal_ear_physiology1.61384569
58MP0005377_hearing/vestibular/ear_phenot1.61384569
59MP0002723_abnormal_immune_serum1.61028928
60MP0001835_abnormal_antigen_presentation1.59397726
61MP0001873_stomach_inflammation1.59111533
62MP0009745_abnormal_behavioral_response1.58586395
63MP0001800_abnormal_humoral_immune1.58397955
64MP0002722_abnormal_immune_system1.58171783
65MP0003300_gastrointestinal_ulcer1.57077317
66MP0002064_seizures1.55270704
67MP0005387_immune_system_phenotype1.54178600
68MP0001790_abnormal_immune_system1.54178600
69MP0002837_dystrophic_cardiac_calcinosis1.48440462
70MP0001502_abnormal_circadian_rhythm1.48270176
71MP0002572_abnormal_emotion/affect_behav1.47570845
72* MP0002429_abnormal_blood_cell1.47130970
73MP0004947_skin_inflammation1.45770884
74MP0003191_abnormal_cellular_cholesterol1.44997032
75MP0000716_abnormal_immune_system1.44497242
76MP0002396_abnormal_hematopoietic_system1.43988854
77MP0002938_white_spotting1.41858785
78MP0003787_abnormal_imprinting1.40543182
79MP0005174_abnormal_tail_pigmentation1.40525738
80MP0000689_abnormal_spleen_morphology1.39287550
81MP0002452_abnormal_antigen_presenting1.38109294
82MP0003866_abnormal_defecation1.36507751
83MP0001440_abnormal_grooming_behavior1.36034145
84MP0003122_maternal_imprinting1.35975148
85MP0001986_abnormal_taste_sensitivity1.34804029
86MP0003879_abnormal_hair_cell1.34029744
87MP0002277_abnormal_respiratory_mucosa1.33807844
88MP0001501_abnormal_sleep_pattern1.33600825
89MP0008961_abnormal_basal_metabolism1.33093372
90MP0002234_abnormal_pharynx_morphology1.31397076
91MP0002405_respiratory_system_inflammati1.31278724
92MP0004185_abnormal_adipocyte_glucose1.31238425
93MP0002132_abnormal_respiratory_system1.30927692
94MP0002557_abnormal_social/conspecific_i1.28973646
95MP0000015_abnormal_ear_pigmentation1.28206784
96MP0002063_abnormal_learning/memory/cond1.26906942
97MP0000858_altered_metastatic_potential1.23182188
98MP0002638_abnormal_pupillary_reflex1.21746233
99MP0004381_abnormal_hair_follicle1.20691845
100MP0001533_abnormal_skeleton_physiology1.20141160
101MP0005551_abnormal_eye_electrophysiolog1.19236868
102MP0004130_abnormal_muscle_cell1.16909197
103MP0005171_absent_coat_pigmentation1.16501165
104MP0000631_abnormal_neuroendocrine_gland1.16326791
105MP0002733_abnormal_thermal_nociception1.13139917
106MP0000490_abnormal_crypts_of1.12188808
107MP0004510_myositis1.11994804
108MP0008569_lethality_at_weaning1.11759996
109MP0001970_abnormal_pain_threshold1.11652116
110MP0002876_abnormal_thyroid_physiology1.11444896
111MP0003183_abnormal_peptide_metabolism1.10412480
112MP0003453_abnormal_keratinocyte_physiol1.10239559
113MP0002653_abnormal_ependyma_morphology1.09635676
114MP0005410_abnormal_fertilization1.08789025
115MP0000003_abnormal_adipose_tissue1.07236970
116MP0000955_abnormal_spinal_cord1.06025302
117MP0000920_abnormal_myelination1.05556873
118MP0004233_abnormal_muscle_weight1.05323854
119MP0005084_abnormal_gallbladder_morpholo1.03378123
120MP0001849_ear_inflammation1.01899003
121MP0001663_abnormal_digestive_system0.99527461
122MP0004808_abnormal_hematopoietic_stem0.98927316
123MP0009785_altered_susceptibility_to0.95706591
124MP0002882_abnormal_neuron_morphology0.93162495
125MP0002148_abnormal_hypersensitivity_rea0.92722239
126MP0010155_abnormal_intestine_physiology0.92242293
127MP0005375_adipose_tissue_phenotype0.92203208
128MP0001984_abnormal_olfaction0.91387645
129MP0008995_early_reproductive_senescence0.90744753
130MP0002184_abnormal_innervation0.90229861
131* MP0009931_abnormal_skin_appearance0.90175088
132MP0002933_joint_inflammation0.90094323
133MP0003959_abnormal_lean_body0.89895804
134MP0000678_abnormal_parathyroid_gland0.89704261
135MP0002177_abnormal_outer_ear0.89608823
136MP0001845_abnormal_inflammatory_respons0.88768953
137MP0000049_abnormal_middle_ear0.88562135
138MP0003566_abnormal_cell_adhesion0.86895722
139MP0003690_abnormal_glial_cell0.86082668
140MP0005423_abnormal_somatic_nervous0.84278724
141MP0002877_abnormal_melanocyte_morpholog0.84276453
142MP0002066_abnormal_motor_capabilities/c0.82763567
143MP0003137_abnormal_impulse_conducting0.82206915
144MP0008874_decreased_physiological_sensi0.81727354
145MP0004036_abnormal_muscle_relaxation0.81452639
146MP0004742_abnormal_vestibular_system0.81307426
147MP0005075_abnormal_melanosome_morpholog0.80245322
148MP0000313_abnormal_cell_death0.78509678
149MP0002019_abnormal_tumor_incidence0.78306190
150MP0004782_abnormal_surfactant_physiolog0.78032509
151MP0000751_myopathy0.77046002
152MP0005386_behavior/neurological_phenoty0.76711659
153MP0004924_abnormal_behavior0.76711659
154MP0005501_abnormal_skin_physiology0.76071530
155MP0005535_abnormal_body_temperature0.75199881
156MP0005253_abnormal_eye_physiology0.74764041
157MP0003111_abnormal_nucleus_morphology0.74136236
158MP0002752_abnormal_somatic_nervous0.73580948
159MP0004811_abnormal_neuron_physiology0.73426044
160MP0008469_abnormal_protein_level0.73343436
161MP0002928_abnormal_bile_duct0.73292600
162MP0006036_abnormal_mitochondrial_physio0.73105766
163MP0008872_abnormal_physiological_respon0.72912449
164MP0003632_abnormal_nervous_system0.71911243
165MP0008877_abnormal_DNA_methylation0.71153137
166MP0001963_abnormal_hearing_physiology0.70948093
167MP0005666_abnormal_adipose_tissue0.70821122
168MP0003121_genomic_imprinting0.69606320
169MP0005381_digestive/alimentary_phenotyp0.69557062
170MP0000613_abnormal_salivary_gland0.69376906
171MP0002095_abnormal_skin_pigmentation0.69227040
172MP0000465_gastrointestinal_hemorrhage0.69177155
173MP0001851_eye_inflammation0.68660358
174MP0005671_abnormal_response_to0.68343180
175MP0006072_abnormal_retinal_apoptosis0.67495980
176MP0002069_abnormal_eating/drinking_beha0.66352853
177MP0000026_abnormal_inner_ear0.65964505
178MP0001270_distended_abdomen0.65629743
179MP0002751_abnormal_autonomic_nervous0.65114927
180MP0006082_CNS_inflammation0.64956131
181MP0002089_abnormal_postnatal_growth/wei0.64480409
182MP0003656_abnormal_erythrocyte_physiolo0.64037949
183MP0005390_skeleton_phenotype0.63969312
184MP0003806_abnormal_nucleotide_metabolis0.63029907
185MP0006035_abnormal_mitochondrial_morpho0.62038488
186MP0005621_abnormal_cell_physiology0.57922744

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.48412922
2Hypochromic anemia (HP:0001931)5.32820306
3Prolonged bleeding time (HP:0003010)4.61838646
4Hypothermia (HP:0002045)4.39149937
5Petechiae (HP:0000967)4.07970338
6Microcytic anemia (HP:0001935)3.99818430
7Reticulocytosis (HP:0001923)3.99573335
8Abnormal hair whorl (HP:0010721)3.91717293
9Acute necrotizing encephalopathy (HP:0006965)3.88897394
10Eczematoid dermatitis (HP:0000976)3.74476559
11Recurrent abscess formation (HP:0002722)3.71398504
12Chronic obstructive pulmonary disease (HP:0006510)3.63044983
13Obstructive lung disease (HP:0006536)3.63044983
14Cholecystitis (HP:0001082)3.46606930
15Abnormal gallbladder physiology (HP:0012438)3.46606930
16Abnormal mitochondria in muscle tissue (HP:0008316)3.44343352
17Abnormal hemoglobin (HP:0011902)3.44308439
18Cholelithiasis (HP:0001081)3.41534273
19Polycythemia (HP:0001901)3.40701853
20Mitochondrial inheritance (HP:0001427)3.34435499
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.33850923
22Hepatocellular necrosis (HP:0001404)3.28659133
23Poikilocytosis (HP:0004447)3.27803216
24Microvesicular hepatic steatosis (HP:0001414)3.21219662
25Epileptic encephalopathy (HP:0200134)3.15014379
26Aplasia/Hypoplasia of the fovea (HP:0008060)3.14664209
27Hypoplasia of the fovea (HP:0007750)3.14664209
28Myopathic facies (HP:0002058)3.13088271
29Purpura (HP:0000979)3.12042314
30Recurrent bacterial skin infections (HP:0005406)3.11748667
31Epistaxis (HP:0000421)3.11338218
32Abnormality of macrophages (HP:0004311)3.03116165
33Hypertensive crisis (HP:0100735)3.02769960
34Protruding tongue (HP:0010808)3.00959770
35Hyperthyroidism (HP:0000836)2.98151400
36Type II lissencephaly (HP:0007260)2.97815971
37Progressive macrocephaly (HP:0004481)2.97118839
38Hyperventilation (HP:0002883)2.97023210
39Acute encephalopathy (HP:0006846)2.93787212
40Gastrointestinal infarctions (HP:0005244)2.92627070
41Abnormality of the fovea (HP:0000493)2.91906337
42Severe visual impairment (HP:0001141)2.89648192
43Abnormal gallbladder morphology (HP:0012437)2.87719757
44Myositis (HP:0100614)2.80478409
45Anomalous pulmonary venous return (HP:0010772)2.80227865
46Easy fatigability (HP:0003388)2.79568824
47Cellulitis (HP:0100658)2.78978124
48Conical tooth (HP:0000698)2.74640895
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73628047
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73628047
51Tubulointerstitial nephritis (HP:0001970)2.72782940
52Abnormal platelet volume (HP:0011876)2.71491067
53Increased CSF lactate (HP:0002490)2.70580016
54Increased serum ferritin (HP:0003281)2.70273123
55Recurrent gram-negative bacterial infections (HP:0005420)2.69429315
56Febrile seizures (HP:0002373)2.68978741
57Progressive external ophthalmoplegia (HP:0000590)2.67060026
58Truncus arteriosus (HP:0001660)2.65774201
59Fair hair (HP:0002286)2.64399115
60Gastrointestinal dysmotility (HP:0002579)2.59494159
61Medial flaring of the eyebrow (HP:0010747)2.58929394
62Abnormality of reticulocytes (HP:0004312)2.58894691
633-Methylglutaconic aciduria (HP:0003535)2.58282618
64Central scotoma (HP:0000603)2.54578154
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.53254694
66Absent/shortened dynein arms (HP:0200106)2.53254694
67Ileus (HP:0002595)2.52524189
68Hepatic necrosis (HP:0002605)2.50428581
69Abnormality of the gallbladder (HP:0005264)2.48310761
70Gingivitis (HP:0000230)2.46449749
71Urticaria (HP:0001025)2.43145066
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42087561
73Abnormality of the pulmonary veins (HP:0011718)2.41881454
74Obstructive sleep apnea (HP:0002870)2.41727982
75Increased IgE level (HP:0003212)2.40731945
76Lissencephaly (HP:0001339)2.40394584
77Optic disc pallor (HP:0000543)2.39555948
78Gastrointestinal inflammation (HP:0004386)2.34572265
79Metaphyseal cupping (HP:0003021)2.33546925
80Impaired platelet aggregation (HP:0003540)2.33038009
81Abnormal platelet function (HP:0011869)2.33038009
82Gingival bleeding (HP:0000225)2.32544080
83Polyphagia (HP:0002591)2.32396713
84Abnormality of iron homeostasis (HP:0011031)2.32236907
85Cerebellar dysplasia (HP:0007033)2.31257043
86Meningitis (HP:0001287)2.30774681
87Hypertriglyceridemia (HP:0002155)2.30678818
88Slow saccadic eye movements (HP:0000514)2.30396890
89Orchitis (HP:0100796)2.29670762
90Increased serum lactate (HP:0002151)2.28040241
91Recurrent fungal infections (HP:0002841)2.24759788
92Atonic seizures (HP:0010819)2.24507910
93Menorrhagia (HP:0000132)2.22878781
94Poor suck (HP:0002033)2.22851317
95Hypoglycemic seizures (HP:0002173)2.21248441
96Blue irides (HP:0000635)2.20897603
97Abnormal pupillary function (HP:0007686)2.19740273
98Gait imbalance (HP:0002141)2.19052792
99Nephrogenic diabetes insipidus (HP:0009806)2.18694601
100Seborrheic dermatitis (HP:0001051)2.17847574
101Congenital primary aphakia (HP:0007707)2.17762981
102Abnormal ciliary motility (HP:0012262)2.17090311
103Atelectasis (HP:0100750)2.16950853
104Abnormality of the heme biosynthetic pathway (HP:0010472)2.16301425
105Abnormal respiratory motile cilium morphology (HP:0005938)2.14593272
106Abnormal respiratory epithelium morphology (HP:0012253)2.14593272
107Lactic acidosis (HP:0003128)2.13846159
108Spontaneous hematomas (HP:0007420)2.13364221
109Pallor (HP:0000980)2.12564480
110Increased connective tissue (HP:0009025)2.11316308
111Distal lower limb muscle weakness (HP:0009053)2.10005902
112Hyperacusis (HP:0010780)2.09768410
113Abnormal delayed hypersensitivity skin test (HP:0002963)2.09466979
114Inflammation of the large intestine (HP:0002037)2.09293858
115Generalized hypopigmentation of hair (HP:0011358)2.08732446
116Paralysis (HP:0003470)2.05984931
117Episodic fever (HP:0001954)2.04704807
118Pustule (HP:0200039)2.04251756
119Exercise intolerance (HP:0003546)2.03507296
120Respiratory failure (HP:0002878)2.03459942
121Annular pancreas (HP:0001734)2.03314751
122Stomatitis (HP:0010280)2.01714898
123Optic nerve hypoplasia (HP:0000609)2.01508537
124Visual hallucinations (HP:0002367)2.01335759
125Retinal dysplasia (HP:0007973)2.01219467
126Dysautonomia (HP:0002459)2.00478150
127Increased mean platelet volume (HP:0011877)2.00131108
128Elevated erythrocyte sedimentation rate (HP:0003565)1.99261561
129Aplasia/Hypoplasia affecting the retina (HP:0008061)1.98246160
130Nephronophthisis (HP:0000090)1.97168351
131Recurrent skin infections (HP:0001581)1.96607323
132Scanning speech (HP:0002168)1.96304753
133Increased variability in muscle fiber diameter (HP:0003557)1.96301260
134Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96249080
135Bowel incontinence (HP:0002607)1.96178543
136Acanthocytosis (HP:0001927)1.95975963
137Bruising susceptibility (HP:0000978)1.95437497
138Hypoplasia of the brainstem (HP:0002365)1.95204675
139Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95204675
140Aplasia cutis congenita (HP:0001057)1.95191999
141Anterior segment dysgenesis (HP:0007700)1.94955263
142Cerebral edema (HP:0002181)1.94633118
143Abnormality of the fingertips (HP:0001211)1.93974750
144Toxemia of pregnancy (HP:0100603)1.93928214
145Meningocele (HP:0002435)1.93260494
146Encephalitis (HP:0002383)1.93081731
147Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91768283
148Degeneration of the lateral corticospinal tracts (HP:0002314)1.91768283
149Symptomatic seizures (HP:0011145)1.91009512
150Abnormal large intestine physiology (HP:0012700)1.89979464
151Anorexia (HP:0002039)1.89585530
152Leukodystrophy (HP:0002415)1.89064605
153Abnormality of the renal collecting system (HP:0004742)1.88317407
154Aplasia/Hypoplasia of the lens (HP:0008063)1.88267515
155Decreased central vision (HP:0007663)1.87311315
156Mediastinal lymphadenopathy (HP:0100721)1.86703085
157Increased IgM level (HP:0003496)1.86580431
158Progressive muscle weakness (HP:0003323)1.86081696
159Aplasia/Hypoplasia of the macula (HP:0008059)1.85291541
160Emphysema (HP:0002097)1.84261123
161Esotropia (HP:0000565)1.83958208
162Nasal polyposis (HP:0100582)1.83248023
163Acne (HP:0001061)1.82525532
164Abnormal respiratory motile cilium physiology (HP:0012261)1.82439531
165Focal motor seizures (HP:0011153)1.82071157
166Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81398130
167Genital tract atresia (HP:0001827)1.81065162
168Hemorrhage of the eye (HP:0011885)1.81063498
169Chest pain (HP:0100749)1.81009820
170Bulbar palsy (HP:0001283)1.80925170
171Xerostomia (HP:0000217)1.79537654
172Hypoparathyroidism (HP:0000829)1.79160500
173Retrobulbar optic neuritis (HP:0100654)1.78541274
174Optic neuritis (HP:0100653)1.78541274
175Asplenia (HP:0001746)1.78439687
176Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78276596
177Neurofibrillary tangles (HP:0002185)1.77318030
178Centrally nucleated skeletal muscle fibers (HP:0003687)1.76612308
179Muscle hypertrophy of the lower extremities (HP:0008968)1.76550598
180Ocular albinism (HP:0001107)1.76500628
181Abnormality of skeletal muscle fiber size (HP:0012084)1.76295162
182Abnormality of transition element cation homeostasis (HP:0011030)1.76052302
183Dyschromatopsia (HP:0007641)1.75280483
184Broad distal phalanx of finger (HP:0009836)1.75133593
185White forelock (HP:0002211)1.74866322
186Limb dystonia (HP:0002451)1.74642256
187Neonatal respiratory distress (HP:0002643)1.74359419
188Myelomeningocele (HP:0002475)1.74117439
189Sensory axonal neuropathy (HP:0003390)1.73296750
190Broad-based gait (HP:0002136)1.73219466
191Vaginal atresia (HP:0000148)1.73196639
192Renal Fanconi syndrome (HP:0001994)1.72116321
193J-shaped sella turcica (HP:0002680)1.71549972
194Sleep apnea (HP:0010535)1.71297038
195Distal lower limb amyotrophy (HP:0008944)1.71041890
196Congenital sensorineural hearing impairment (HP:0008527)1.71016871
197Chronic hepatic failure (HP:0100626)1.67770329
198Abnormality of the renal medulla (HP:0100957)1.67306871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.62219253
2TRIB34.14407717
3CDK193.92851096
4SIK33.80783463
5ERN13.37491324
6TNIK3.31137407
7RIPK43.23645810
8MAP4K13.03670824
9MAP3K122.99239870
10MAP2K32.94152467
11BCR2.60972780
12SIK12.59999426
13MAPK132.57738022
14TLK12.57251162
15SMG12.51616282
16GRK62.46222470
17IRAK42.39046502
18ICK2.24908332
19MAP3K112.21937999
20TAOK12.20376592
21TAOK22.04649888
22STK162.03666813
23MAP3K141.81427817
24IRAK31.76089239
25SIK21.66948699
26EPHB11.57717110
27TXK1.57057731
28MARK31.54458200
29IRAK21.52590967
30NTRK31.49585019
31MAP3K31.49313952
32MAP2K71.47865326
33NEK61.46785222
34BMX1.46512780
35UHMK11.45871776
36NTRK21.45578461
37MARK21.44173749
38INSRR1.43663227
39PKN21.39344777
40BMPR21.38837831
41KSR21.35830276
42FGFR41.31284480
43PNCK1.23005572
44MAP3K11.21729168
45GRK71.21516577
46CDK121.19956209
47YES11.18488401
48HIPK21.17838364
49PTK61.17405798
50VRK11.17345641
51PRPF4B1.17191635
52BMPR1B1.16919727
53GRK51.12781632
54TESK21.12653117
55ZAP701.11034984
56CSK1.10681182
57FES1.09982353
58BTK1.09522187
59CDK81.07918158
60PDPK11.07209391
61MUSK1.05999587
62TYK21.05350154
63IKBKE1.04173746
64EIF2AK11.03341596
65FGR1.02785733
66PKN11.02609301
67BRD41.00744380
68KIT1.00580427
69ZAK1.00140293
70IRAK10.99881555
71BLK0.97418675
72MAPK120.95798177
73STK390.94558276
74HCK0.92999288
75MYLK0.92384890
76FGFR20.92324865
77EEF2K0.92017151
78CLK10.91809940
79MAP3K100.90444453
80TSSK60.88722539
81CDC42BPA0.87393912
82DYRK1A0.83354932
83MINK10.83251455
84PASK0.80223476
85NME20.79700193
86TIE10.79439836
87MAPKAPK50.77309748
88OXSR10.76865894
89CAMKK10.76277415
90LRRK20.75878180
91PDK10.73594132
92CCNB10.72700666
93RPS6KL10.71352238
94RPS6KC10.71352238
95WNK40.70315626
96MAP2K20.66935992
97MAP3K70.66788558
98STK380.66659552
99ERBB30.65299452
100PRKCH0.65250161
101MAPK110.65142106
102RPS6KA20.65051380
103KSR10.63133073
104PIK3CG0.62012138
105MTOR0.60867978
106MAP3K130.60234991
107PRKD30.60115085
108SYK0.59864990
109MAP3K40.58528992
110MAP3K80.58353092
111RPS6KA60.56771274
112TESK10.56581102
113MAPK70.56099640
114BRAF0.56075787
115MAPKAPK20.54621304
116MAPK150.54339805
117IKBKB0.53396834
118MATK0.52921246
119STK110.52838298
120PAK30.51835338
121CDK40.51661744
122AKT30.51174632
123TNK20.50620466
124TTN0.50534575
125EIF2AK20.50332650
126PRKCQ0.50142486
127PTK2B0.49630573
128OBSCN0.49054228
129CDK11A0.48611140
130JAK30.48179015
131GRK10.47335129
132SGK4940.47108905
133SGK2230.47108905
134PRKCE0.46623580
135CDK180.46522512
136ADRBK20.45799207
137ADRBK10.44879203
138ARAF0.44628258
139PRKD10.44608003
140RAF10.43838339
141DYRK1B0.43538688
142PAK40.43120063
143RET0.42816635
144BRSK10.42762699
145MST40.42634786
146CDK50.42595192
147MAP2K40.42067415
148PRKACA0.41072536
149MAP2K60.40883336
150CAMK2G0.40766271
151ILK0.40327943
152NTRK10.39680075
153KDR0.39261161
154CAMK2A0.39226665
155ROCK20.39218420
156NME10.38842573
157CAMK2D0.38696800
158PAK10.38381819
159CDK70.38268283
160PRKD20.38222353
161LCK0.37948583
162VRK20.37695224
163CAMK2B0.37678543
164TYRO30.37084361
165TBK10.35901904
166JAK20.35260927
167LYN0.34849755
168STK100.34221558
169WNK10.34075471
170SRPK10.33556774
171MAPKAPK30.33469923
172PRKCI0.32897287
173PRKG10.31952269
174CDK30.27743510
175PRKCD0.27629966

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.27018594
2Parkinsons disease_Homo sapiens_hsa050123.25451831
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.95020593
4Protein export_Homo sapiens_hsa030602.82723908
5Acute myeloid leukemia_Homo sapiens_hsa052212.78490058
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60385795
7Collecting duct acid secretion_Homo sapiens_hsa049662.53914203
8Alzheimers disease_Homo sapiens_hsa050102.51084639
9Non-small cell lung cancer_Homo sapiens_hsa052232.35616661
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28676067
11Huntingtons disease_Homo sapiens_hsa050162.22755988
12B cell receptor signaling pathway_Homo sapiens_hsa046622.22081897
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.20319426
14Nicotine addiction_Homo sapiens_hsa050332.20299944
15SNARE interactions in vesicular transport_Homo sapiens_hsa041302.16159509
16Malaria_Homo sapiens_hsa051442.13057823
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.12889570
18Chronic myeloid leukemia_Homo sapiens_hsa052202.05393180
19Vibrio cholerae infection_Homo sapiens_hsa051102.00023170
20Synaptic vesicle cycle_Homo sapiens_hsa047211.99795121
21Cardiac muscle contraction_Homo sapiens_hsa042601.99433150
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96746948
23Sulfur relay system_Homo sapiens_hsa041221.96240902
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92421464
25Osteoclast differentiation_Homo sapiens_hsa043801.91687503
26VEGF signaling pathway_Homo sapiens_hsa043701.89701698
27Notch signaling pathway_Homo sapiens_hsa043301.86656784
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78570316
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.77889885
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76618066
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74156615
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.73083578
33Other glycan degradation_Homo sapiens_hsa005111.72834662
34Morphine addiction_Homo sapiens_hsa050321.70226042
35Pancreatic cancer_Homo sapiens_hsa052121.69841550
36Insulin secretion_Homo sapiens_hsa049111.67650717
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66266108
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62875667
39Leishmaniasis_Homo sapiens_hsa051401.62728966
40Serotonergic synapse_Homo sapiens_hsa047261.62226656
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56932575
42mTOR signaling pathway_Homo sapiens_hsa041501.43817344
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43026516
44Circadian entrainment_Homo sapiens_hsa047131.40072479
45Rheumatoid arthritis_Homo sapiens_hsa053231.39883023
46Ribosome_Homo sapiens_hsa030101.38824016
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36014991
48Glutamatergic synapse_Homo sapiens_hsa047241.31753934
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31387332
50Fructose and mannose metabolism_Homo sapiens_hsa000511.30437834
51Bladder cancer_Homo sapiens_hsa052191.28644810
52Endometrial cancer_Homo sapiens_hsa052131.27977884
53GABAergic synapse_Homo sapiens_hsa047271.25724009
54RNA polymerase_Homo sapiens_hsa030201.25623357
55Amphetamine addiction_Homo sapiens_hsa050311.25273755
56Renal cell carcinoma_Homo sapiens_hsa052111.22950962
57Platelet activation_Homo sapiens_hsa046111.21744524
58Chemokine signaling pathway_Homo sapiens_hsa040621.21584988
59Fatty acid elongation_Homo sapiens_hsa000621.19291994
60Phototransduction_Homo sapiens_hsa047441.19132643
61Pentose phosphate pathway_Homo sapiens_hsa000301.18718307
62Neurotrophin signaling pathway_Homo sapiens_hsa047221.16667499
63Steroid biosynthesis_Homo sapiens_hsa001001.15161426
64Cocaine addiction_Homo sapiens_hsa050301.14787993
65Hepatitis C_Homo sapiens_hsa051601.12858906
66Endocytosis_Homo sapiens_hsa041441.10179651
67Central carbon metabolism in cancer_Homo sapiens_hsa052301.08818380
68Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08365451
69Tuberculosis_Homo sapiens_hsa051521.07691406
70Adipocytokine signaling pathway_Homo sapiens_hsa049201.05940354
71Apoptosis_Homo sapiens_hsa042101.05628503
72Choline metabolism in cancer_Homo sapiens_hsa052311.03665858
73Autoimmune thyroid disease_Homo sapiens_hsa053201.03178555
74Taste transduction_Homo sapiens_hsa047421.02528583
75Glioma_Homo sapiens_hsa052141.02105985
76Hepatitis B_Homo sapiens_hsa051611.01795193
77Phospholipase D signaling pathway_Homo sapiens_hsa040721.01407865
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00478699
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.99042739
80Calcium signaling pathway_Homo sapiens_hsa040200.98905422
81Insulin signaling pathway_Homo sapiens_hsa049100.95274279
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95249243
83Axon guidance_Homo sapiens_hsa043600.94840847
84Dopaminergic synapse_Homo sapiens_hsa047280.93798312
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.93347211
86Thyroid cancer_Homo sapiens_hsa052160.93179779
87Shigellosis_Homo sapiens_hsa051310.93044003
88HTLV-I infection_Homo sapiens_hsa051660.91415621
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91218221
90African trypanosomiasis_Homo sapiens_hsa051430.90796049
91AMPK signaling pathway_Homo sapiens_hsa041520.90737459
92Toxoplasmosis_Homo sapiens_hsa051450.89696478
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88236869
94Herpes simplex infection_Homo sapiens_hsa051680.88126250
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86580969
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.86141121
97Influenza A_Homo sapiens_hsa051640.85119599
98Base excision repair_Homo sapiens_hsa034100.84442751
99Olfactory transduction_Homo sapiens_hsa047400.83294974
100Proteasome_Homo sapiens_hsa030500.80280297
101Inositol phosphate metabolism_Homo sapiens_hsa005620.78212517
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78077164
103Colorectal cancer_Homo sapiens_hsa052100.78040608
104Viral carcinogenesis_Homo sapiens_hsa052030.77297562
105Pyrimidine metabolism_Homo sapiens_hsa002400.77150855
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76819183
107Prolactin signaling pathway_Homo sapiens_hsa049170.75803379
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74052100
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.73880102
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72797236
111Cholinergic synapse_Homo sapiens_hsa047250.72659719
112Alcoholism_Homo sapiens_hsa050340.71833809
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70546737
114MAPK signaling pathway_Homo sapiens_hsa040100.70313421
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.70032910
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69922417
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69719276
118Purine metabolism_Homo sapiens_hsa002300.67417634
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66465068
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65981706
121Measles_Homo sapiens_hsa051620.65953288
122Arachidonic acid metabolism_Homo sapiens_hsa005900.65222763
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64691729
124Insulin resistance_Homo sapiens_hsa049310.64600909
125Peroxisome_Homo sapiens_hsa041460.64401521
126Prostate cancer_Homo sapiens_hsa052150.62110947
127TNF signaling pathway_Homo sapiens_hsa046680.61659122
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61494833
129Fanconi anemia pathway_Homo sapiens_hsa034600.60905229
130GnRH signaling pathway_Homo sapiens_hsa049120.60645793
131Regulation of autophagy_Homo sapiens_hsa041400.59657602
132Sphingolipid metabolism_Homo sapiens_hsa006000.59091155
133Ether lipid metabolism_Homo sapiens_hsa005650.59075157
134Hematopoietic cell lineage_Homo sapiens_hsa046400.58999969
135Long-term depression_Homo sapiens_hsa047300.57905919
136HIF-1 signaling pathway_Homo sapiens_hsa040660.57848753
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57555660
138Small cell lung cancer_Homo sapiens_hsa052220.57153702
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56974215
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56425398
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55831541
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55732726
143Cyanoamino acid metabolism_Homo sapiens_hsa004600.55344680
144FoxO signaling pathway_Homo sapiens_hsa040680.55129877
145Metabolic pathways_Homo sapiens_hsa011000.54731818
146Vitamin B6 metabolism_Homo sapiens_hsa007500.54083887
147Rap1 signaling pathway_Homo sapiens_hsa040150.53857167
148Non-homologous end-joining_Homo sapiens_hsa034500.53022179
149Melanogenesis_Homo sapiens_hsa049160.52973064
150Viral myocarditis_Homo sapiens_hsa054160.52943004
151Long-term potentiation_Homo sapiens_hsa047200.52585730
152Staphylococcus aureus infection_Homo sapiens_hsa051500.51339309
153Allograft rejection_Homo sapiens_hsa053300.48958805
154Graft-versus-host disease_Homo sapiens_hsa053320.48761271
155Estrogen signaling pathway_Homo sapiens_hsa049150.48634338
156Tyrosine metabolism_Homo sapiens_hsa003500.46883063
157Phagosome_Homo sapiens_hsa041450.45856551
158NF-kappa B signaling pathway_Homo sapiens_hsa040640.45577373
159Primary immunodeficiency_Homo sapiens_hsa053400.44958872
160Pancreatic secretion_Homo sapiens_hsa049720.43094214
161Type I diabetes mellitus_Homo sapiens_hsa049400.42311398
162ErbB signaling pathway_Homo sapiens_hsa040120.39625615
163Tryptophan metabolism_Homo sapiens_hsa003800.39614386
164Intestinal immune network for IgA production_Homo sapiens_hsa046720.37718850
165Basal transcription factors_Homo sapiens_hsa030220.34596381
166RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32172782
167Phenylalanine metabolism_Homo sapiens_hsa003600.31526894
168Systemic lupus erythematosus_Homo sapiens_hsa053220.31478064
169Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29822327
170ABC transporters_Homo sapiens_hsa020100.29063754
171Homologous recombination_Homo sapiens_hsa034400.27708995
172Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27180355
173Salivary secretion_Homo sapiens_hsa049700.26487605
174T cell receptor signaling pathway_Homo sapiens_hsa046600.24480283
175Oxytocin signaling pathway_Homo sapiens_hsa049210.24013129
176Renin secretion_Homo sapiens_hsa049240.23820187
177Epstein-Barr virus infection_Homo sapiens_hsa051690.23282834
178Dilated cardiomyopathy_Homo sapiens_hsa054140.22722535
179Histidine metabolism_Homo sapiens_hsa003400.22323440
180Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21789310

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