NPSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.57016088
2axon ensheathment in central nervous system (GO:0032291)9.57016088
3centriole replication (GO:0007099)8.34400694
4positive regulation of histone deacetylation (GO:0031065)6.86141056
5N-acetylneuraminate metabolic process (GO:0006054)6.72658078
6regulation of MHC class II biosynthetic process (GO:0045346)6.26002080
7protoporphyrinogen IX biosynthetic process (GO:0006782)6.20120667
8centriole assembly (GO:0098534)5.76174598
9cellular extravasation (GO:0045123)5.28809443
10regulation of helicase activity (GO:0051095)5.13218681
11protoporphyrinogen IX metabolic process (GO:0046501)4.98991048
12positive regulation of protein deacetylation (GO:0090312)4.73018593
13neuromuscular process controlling posture (GO:0050884)4.69725119
14base-excision repair, AP site formation (GO:0006285)4.58309713
15negative regulation of neurotransmitter transport (GO:0051589)4.57227329
16establishment of mitochondrion localization (GO:0051654)4.56916070
17long-chain fatty acid biosynthetic process (GO:0042759)4.55252298
18cytokinetic process (GO:0032506)4.53901346
19thalamus development (GO:0021794)4.53288018
20insulin-like growth factor receptor signaling pathway (GO:0048009)4.48528566
21ensheathment of neurons (GO:0007272)4.47268364
22axon ensheathment (GO:0008366)4.47268364
23myelination (GO:0042552)4.45031733
24myelin maintenance (GO:0043217)4.38663190
25DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.30939687
26fatty acid elongation (GO:0030497)4.28189701
27positive regulation of chemokine biosynthetic process (GO:0045080)4.20784276
28L-fucose catabolic process (GO:0042355)4.18772646
29fucose catabolic process (GO:0019317)4.18772646
30L-fucose metabolic process (GO:0042354)4.18772646
31amino sugar catabolic process (GO:0046348)4.18490261
32protein neddylation (GO:0045116)4.17538329
33microglial cell activation (GO:0001774)4.14901130
34negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.13966344
35presynaptic membrane organization (GO:0097090)4.11834132
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.11160001
37N-acetylglucosamine metabolic process (GO:0006044)4.03689661
38epithelial cilium movement (GO:0003351)3.98920911
39leukotriene biosynthetic process (GO:0019370)3.88321292
40nonmotile primary cilium assembly (GO:0035058)3.87991583
41detection of temperature stimulus involved in sensory perception (GO:0050961)3.81700674
42detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.81700674
43positive regulation of oligodendrocyte differentiation (GO:0048714)3.81592252
44negative regulation of neurotransmitter secretion (GO:0046929)3.77776163
45regulation of chemokine biosynthetic process (GO:0045073)3.77118907
46negative regulation of acute inflammatory response (GO:0002674)3.76026979
47substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.73976581
48substrate-independent telencephalic tangential migration (GO:0021826)3.73976581
49regulation of histone deacetylation (GO:0031063)3.73123285
50L-amino acid import (GO:0043092)3.71916073
51DNA damage response, signal transduction resulting in transcription (GO:0042772)3.70750179
52cellular response to cadmium ion (GO:0071276)3.64306557
53limb bud formation (GO:0060174)3.63949472
54dopamine biosynthetic process (GO:0042416)3.60011012
55reactive oxygen species biosynthetic process (GO:1903409)3.55754036
56positive regulation of histone H3-K4 methylation (GO:0051571)3.51812624
57chaperone-mediated protein transport (GO:0072321)3.49642367
58creatine metabolic process (GO:0006600)3.47350392
59positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.44432682
60removal of superoxide radicals (GO:0019430)3.39749712
61cellular response to superoxide (GO:0071451)3.39749712
62cellular response to oxygen radical (GO:0071450)3.39749712
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.36232943
64L-phenylalanine catabolic process (GO:0006559)3.36232943
65negative regulation of protein localization to cell surface (GO:2000009)3.33492542
66oligodendrocyte differentiation (GO:0048709)3.32518959
67glomerular visceral epithelial cell development (GO:0072015)3.29784987
68photoreceptor cell differentiation (GO:0046530)3.27656871
69eye photoreceptor cell differentiation (GO:0001754)3.27656871
70somite rostral/caudal axis specification (GO:0032525)3.26622290
71negative regulation of amino acid transport (GO:0051956)3.26315197
72response to methylmercury (GO:0051597)3.25240214
73ventricular system development (GO:0021591)3.24629250
74regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.23252372
75regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.23252372
76early endosome to late endosome transport (GO:0045022)3.19426337
77response to redox state (GO:0051775)3.15746569
78cilium movement (GO:0003341)3.12519130
79negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.11762979
80modulation of growth of symbiont involved in interaction with host (GO:0044144)3.11762979
81regulation of growth of symbiont in host (GO:0044126)3.11762979
82negative regulation of growth of symbiont in host (GO:0044130)3.11762979
83response to misfolded protein (GO:0051788)3.09254393
84ovulation from ovarian follicle (GO:0001542)3.06872135
85imidazole-containing compound metabolic process (GO:0052803)3.06732674
86protein polyglutamylation (GO:0018095)3.06516173
87import into cell (GO:0098657)3.04816373
88response to oxygen radical (GO:0000305)3.03384793
89positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.03317547
90detection of temperature stimulus (GO:0016048)3.03237343
91pyrimidine dimer repair (GO:0006290)3.02109209
92seminiferous tubule development (GO:0072520)3.02076298
93killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.02059835
94disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.02059835
95detection of light stimulus involved in visual perception (GO:0050908)3.01912279
96detection of light stimulus involved in sensory perception (GO:0050962)3.01912279
97enteric nervous system development (GO:0048484)2.98331174
98adult walking behavior (GO:0007628)2.97424590
99protein prenylation (GO:0018342)2.97291494
100prenylation (GO:0097354)2.97291494
101axoneme assembly (GO:0035082)2.96320969
102male meiosis (GO:0007140)2.96243900
103regulation of lipoprotein metabolic process (GO:0050746)2.95021509
104positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.94834176
105nucleotide transmembrane transport (GO:1901679)2.94641375
106presynaptic membrane assembly (GO:0097105)2.94401783
107aldehyde catabolic process (GO:0046185)2.92875290
108nerve growth factor signaling pathway (GO:0038180)2.91480629
109regulation of protein import into nucleus, translocation (GO:0033158)2.88683520
110photoreceptor cell maintenance (GO:0045494)2.88631594
111glomerular epithelial cell development (GO:0072310)2.85589196
112apical protein localization (GO:0045176)2.85043153
113CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.83210107
114purine deoxyribonucleotide catabolic process (GO:0009155)2.82084877
115mating behavior (GO:0007617)2.80666133
116transcription from mitochondrial promoter (GO:0006390)2.80235933
117reciprocal meiotic recombination (GO:0007131)2.79652963
118reciprocal DNA recombination (GO:0035825)2.79652963
119response to nitrosative stress (GO:0051409)2.79100001
120neuronal action potential propagation (GO:0019227)2.77325031
121glucosamine-containing compound metabolic process (GO:1901071)2.76136099
122establishment of protein localization to Golgi (GO:0072600)2.75030534
123ribosomal small subunit biogenesis (GO:0042274)2.73842070
124prostate gland growth (GO:0060736)2.73756045
125behavioral response to ethanol (GO:0048149)2.73356774
126leukotriene metabolic process (GO:0006691)2.73260533
127glycine transport (GO:0015816)2.69984461
128rRNA methylation (GO:0031167)2.69909199
129regulation of meiosis I (GO:0060631)2.69690432
130peptidyl-glutamic acid modification (GO:0018200)2.68970394
131negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.68174831
132indolalkylamine metabolic process (GO:0006586)2.67516297
133astrocyte development (GO:0014002)2.65803242
134asymmetric protein localization (GO:0008105)2.65790463
135erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.65631534
136L-phenylalanine metabolic process (GO:0006558)2.65631534
137microtubule polymerization or depolymerization (GO:0031109)2.64850185
138male meiosis I (GO:0007141)2.64826165
139negative regulation of androgen receptor signaling pathway (GO:0060766)2.63770643
140defense response to fungus (GO:0050832)2.63689661
141tryptophan metabolic process (GO:0006568)2.62603288
142catecholamine biosynthetic process (GO:0042423)2.62202811
143catechol-containing compound biosynthetic process (GO:0009713)2.62202811
144regulation of dopamine metabolic process (GO:0042053)2.60980008
145regulation of catecholamine metabolic process (GO:0042069)2.60980008
146UDP-N-acetylglucosamine metabolic process (GO:0006047)2.60565803
147cellular ketone body metabolic process (GO:0046950)2.60104681
148cerebral cortex radially oriented cell migration (GO:0021799)2.59875662
149negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.59034449
150glutathione biosynthetic process (GO:0006750)2.58792430
151ionotropic glutamate receptor signaling pathway (GO:0035235)2.57591651
152peripheral nervous system axon ensheathment (GO:0032292)2.57559078
153myelination in peripheral nervous system (GO:0022011)2.57559078
154CD4-positive, alpha-beta T cell activation (GO:0035710)2.57351976
155positive regulation of pseudopodium assembly (GO:0031274)2.57214372
156RNA destabilization (GO:0050779)2.56935895
157nonribosomal peptide biosynthetic process (GO:0019184)2.56498375
158receptor catabolic process (GO:0032801)2.56288881
159neurotransmitter catabolic process (GO:0042135)2.56250363
160regulation of glutamate secretion (GO:0014048)2.56235852
161response to superoxide (GO:0000303)2.55670954
162peptidyl-tyrosine autophosphorylation (GO:0038083)2.55592637
163glutamate receptor signaling pathway (GO:0007215)2.55409706
164single strand break repair (GO:0000012)2.55361372
165cholesterol biosynthetic process (GO:0006695)2.53867469
166sperm motility (GO:0030317)2.53789237
167positive regulation of chemokine secretion (GO:0090197)2.52277758
168negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51388291
169establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51031076
170mitochondrion transport along microtubule (GO:0047497)2.51031076
171cerebellar Purkinje cell layer development (GO:0021680)2.50510213
172regulation of dendritic cell antigen processing and presentation (GO:0002604)2.50038911
173neuron recognition (GO:0008038)2.47852813
174membrane tubulation (GO:0097320)2.47426599
175negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.47232963
176ER overload response (GO:0006983)2.47190245
177neuron cell-cell adhesion (GO:0007158)2.46793578
178regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.46281513
179protein localization to endosome (GO:0036010)2.44442904
180negative regulation of response to reactive oxygen species (GO:1901032)2.43494269
181regulation of heat generation (GO:0031650)2.43096607
182metanephric nephron tubule development (GO:0072234)2.42964759
183metanephric tubule development (GO:0072170)2.42964759
184positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.42089299
185negative regulation of chemokine production (GO:0032682)2.41927980
186sarcoplasmic reticulum calcium ion transport (GO:0070296)2.39994218
187regulation of collateral sprouting (GO:0048670)2.39981280
188glycerophospholipid catabolic process (GO:0046475)2.38822565
189protein K11-linked deubiquitination (GO:0035871)2.38101913
190positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.37609449
191regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.37121514
192axon development (GO:0061564)2.36958505
193amino acid import (GO:0043090)2.35804692
194response to lipoprotein particle (GO:0055094)2.35599837
195neuron remodeling (GO:0016322)2.32543458
196positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.32192112
197primary alcohol catabolic process (GO:0034310)2.31859830
198sterol biosynthetic process (GO:0016126)2.31745770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28931343
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.38764196
3IGF1R_20145208_ChIP-Seq_DFB_Human3.19511524
4* GBX2_23144817_ChIP-Seq_PC3_Human2.85006901
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.66039431
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52336861
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50909775
8ZNF274_21170338_ChIP-Seq_K562_Hela2.34010123
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26574363
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21589071
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17330368
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14399973
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14208191
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13672018
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13672018
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05796559
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02560837
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00825954
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00581715
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.99138561
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96051557
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.95001379
23BCAT_22108803_ChIP-Seq_LS180_Human1.91357371
24TAF15_26573619_Chip-Seq_HEK293_Human1.88036293
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87645276
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.87549796
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87334513
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.87001866
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81083150
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80993839
31AR_21572438_ChIP-Seq_LNCaP_Human1.70344579
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.69070628
33* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66723500
34FUS_26573619_Chip-Seq_HEK293_Human1.62133344
35SOX2_19829295_ChIP-Seq_ESCs_Human1.61251520
36NANOG_19829295_ChIP-Seq_ESCs_Human1.61251520
37REST_21632747_ChIP-Seq_MESCs_Mouse1.60800212
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59697788
39CBP_20019798_ChIP-Seq_JUKART_Human1.59697788
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56230454
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56230454
42STAT3_23295773_ChIP-Seq_U87_Human1.56204943
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55397589
44DROSHA_22980978_ChIP-Seq_HELA_Human1.54774031
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54658356
46* TCF4_23295773_ChIP-Seq_U87_Human1.51990495
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48062602
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46421774
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44286773
50P53_22127205_ChIP-Seq_FIBROBLAST_Human1.44211619
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43379197
52CJUN_26792858_Chip-Seq_BT549_Human1.40554931
53* CDX2_22108803_ChIP-Seq_LS180_Human1.39799538
54TCF4_22108803_ChIP-Seq_LS180_Human1.38196912
55TP53_18474530_ChIP-ChIP_U2OS_Human1.36536177
56TP53_16413492_ChIP-PET_HCT116_Human1.36129542
57* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35703969
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35211260
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34717751
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32186697
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31695442
62P300_19829295_ChIP-Seq_ESCs_Human1.31291153
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30845247
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.29138801
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29119519
66VDR_22108803_ChIP-Seq_LS180_Human1.28850267
67HOXB7_26014856_ChIP-Seq_BT474_Human1.28575047
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27300751
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27163202
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27097961
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27097961
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.26319347
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.26095217
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25982813
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25933296
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25177109
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.25034180
78TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24328153
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.24156626
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.24116043
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23251266
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.23116658
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22375341
84RUNX2_22187159_ChIP-Seq_PCA_Human1.22141860
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.21291048
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.21281181
87* SMAD4_21799915_ChIP-Seq_A2780_Human1.19976233
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19910988
89* TP53_22573176_ChIP-Seq_HFKS_Human1.19298230
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18298008
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16893599
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.16893599
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16019663
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15697536
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15209718
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.14922488
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.14468359
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13547860
99GATA4_25053715_ChIP-Seq_YYC3_Human1.13364280
100AR_20517297_ChIP-Seq_VCAP_Human1.13159623
101NCOR_22424771_ChIP-Seq_293T_Human1.12903497
102* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12795052
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12736180
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12075471
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11904007
106ER_23166858_ChIP-Seq_MCF-7_Human1.10885223
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10830405
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10258930
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10017042
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09164894
111* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08526208
112IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08232218
113IRF1_19129219_ChIP-ChIP_H3396_Human1.07971985
114NANOG_20526341_ChIP-Seq_ESCs_Human1.07909698
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07109208
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06975407
117SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06828624
118* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06271553
119EGR1_19032775_ChIP-ChIP_M12_Human1.05347645
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.05195571
121WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04715189
122BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04562464
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.04433463
124SALL1_21062744_ChIP-ChIP_HESCs_Human1.04264438
125RING1B_27294783_Chip-Seq_ESCs_Mouse1.03888049
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03595862
127FOXO3_23340844_ChIP-Seq_DLD1_Human1.03479486
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03362874
129CMYC_18555785_Chip-Seq_ESCs_Mouse1.03309325
130CBX2_27304074_Chip-Seq_ESCs_Mouse1.03190306
131EWS_26573619_Chip-Seq_HEK293_Human1.02505885
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02224877
133RARB_27405468_Chip-Seq_BRAIN_Mouse1.01977802
134ERG_20517297_ChIP-Seq_VCAP_Human1.01614925
135NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01215693
136PRDM14_20953172_ChIP-Seq_ESCs_Human1.00851951
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99875760
138ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99415402
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.98577794
140POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98229679
141* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97843688
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97771572
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.96200624
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95834390
145ESR2_21235772_ChIP-Seq_MCF-7_Human0.94681271
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94072805
147AHR_22903824_ChIP-Seq_MCF-7_Human0.92314296
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91235770
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90768834
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.90724086
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90091822
152VDR_24787735_ChIP-Seq_THP-1_Human0.87574031
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85542976
154P300_18555785_Chip-Seq_ESCs_Mouse0.84934690
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83702050
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83625909
157E2F1_18555785_Chip-Seq_ESCs_Mouse0.83181775
158RXR_22108803_ChIP-Seq_LS180_Human0.82313258
159AR_25329375_ChIP-Seq_VCAP_Human0.81513543
160TAL1_26923725_Chip-Seq_HPCs_Mouse0.81487047
161* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81439335
162EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81419847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism4.31927090
2MP0000920_abnormal_myelination4.10816150
3MP0003950_abnormal_plasma_membrane4.00091765
4MP0005670_abnormal_white_adipose3.82320109
5MP0004043_abnormal_pH_regulation3.66674025
6MP0005085_abnormal_gallbladder_physiolo3.51364552
7MP0005365_abnormal_bile_salt3.33566228
8MP0003195_calcinosis3.24998783
9MP0003252_abnormal_bile_duct3.14517920
10MP0008057_abnormal_DNA_replication3.10644147
11MP0003880_abnormal_central_pattern2.85411365
12MP0005645_abnormal_hypothalamus_physiol2.84443722
13MP0004859_abnormal_synaptic_plasticity2.77780735
14MP0005171_absent_coat_pigmentation2.74360894
15MP0003183_abnormal_peptide_metabolism2.68159864
16MP0003690_abnormal_glial_cell2.64302515
17MP0001984_abnormal_olfaction2.59394508
18MP0002064_seizures2.50850805
19MP0008058_abnormal_DNA_repair2.49209963
20MP0008877_abnormal_DNA_methylation2.47219347
21MP0002909_abnormal_adrenal_gland2.47034767
22MP0004270_analgesia2.40632860
23MP0002254_reproductive_system_inflammat2.39559447
24MP0002272_abnormal_nervous_system2.36817741
25MP0005379_endocrine/exocrine_gland_phen2.28897797
26MP0001529_abnormal_vocalization2.26535742
27MP0004019_abnormal_vitamin_homeostasis2.24806739
28MP0002735_abnormal_chemical_nociception2.19581269
29MP0010329_abnormal_lipoprotein_level2.05471937
30MP0003635_abnormal_synaptic_transmissio2.04423754
31MP0008260_abnormal_autophagy2.04365821
32MP0005377_hearing/vestibular/ear_phenot2.03691951
33MP0003878_abnormal_ear_physiology2.03691951
34MP0009745_abnormal_behavioral_response2.01473582
35MP0010234_abnormal_vibrissa_follicle2.00447610
36MP0009046_muscle_twitch2.00415489
37MP0005423_abnormal_somatic_nervous2.00254467
38MP0001486_abnormal_startle_reflex1.98060262
39MP0005451_abnormal_body_composition1.91524720
40MP0001501_abnormal_sleep_pattern1.91427492
41MP0002734_abnormal_mechanical_nocicepti1.90126008
42MP0003329_amyloid_beta_deposits1.86190185
43MP0001346_abnormal_lacrimal_gland1.81341059
44MP0005083_abnormal_biliary_tract1.80428990
45MP0004742_abnormal_vestibular_system1.74091422
46MP0001905_abnormal_dopamine_level1.72850168
47MP0003806_abnormal_nucleotide_metabolis1.72580175
48MP0001970_abnormal_pain_threshold1.72098614
49MP0006082_CNS_inflammation1.70112646
50MP0004142_abnormal_muscle_tone1.65501094
51MP0003634_abnormal_glial_cell1.65433621
52MP0003718_maternal_effect1.65073053
53MP0009115_abnormal_fat_cell1.59406420
54MP0002876_abnormal_thyroid_physiology1.58067190
55MP0002733_abnormal_thermal_nociception1.57782838
56MP0001968_abnormal_touch/_nociception1.54724710
57MP0005409_darkened_coat_color1.54172352
58MP0010386_abnormal_urinary_bladder1.53068481
59MP0000778_abnormal_nervous_system1.50705659
60MP0002063_abnormal_learning/memory/cond1.49932012
61MP0005367_renal/urinary_system_phenotyp1.47672810
62MP0000516_abnormal_urinary_system1.47672810
63MP0001765_abnormal_ion_homeostasis1.47173598
64MP0003136_yellow_coat_color1.46647162
65MP0004885_abnormal_endolymph1.46561941
66MP0009840_abnormal_foam_cell1.40704156
67MP0003123_paternal_imprinting1.40208414
68MP0003633_abnormal_nervous_system1.36938060
69MP0001348_abnormal_lacrimal_gland1.34266251
70MP0009697_abnormal_copulation1.33473860
71MP0003631_nervous_system_phenotype1.32919162
72MP0002638_abnormal_pupillary_reflex1.31952405
73MP0001440_abnormal_grooming_behavior1.28983548
74MP0002572_abnormal_emotion/affect_behav1.27980639
75MP0003698_abnormal_male_reproductive1.23649072
76MP0001756_abnormal_urination1.22210545
77MP0008569_lethality_at_weaning1.21979095
78MP0001502_abnormal_circadian_rhythm1.16052894
79MP0003075_altered_response_to1.15921741
80MP0005386_behavior/neurological_phenoty1.14065434
81MP0004924_abnormal_behavior1.14065434
82MP0010678_abnormal_skin_adnexa1.13694024
83MP0009643_abnormal_urine_homeostasis1.13283912
84MP0001986_abnormal_taste_sensitivity1.11024576
85MP0005310_abnormal_salivary_gland1.10265092
86MP0004510_myositis1.10094411
87MP0008874_decreased_physiological_sensi1.08082299
88MP0002067_abnormal_sensory_capabilities1.07962766
89MP0005220_abnormal_exocrine_pancreas1.07215542
90MP0005266_abnormal_metabolism1.06913257
91MP0005448_abnormal_energy_balance1.06699520
92MP0005410_abnormal_fertilization1.06345798
93MP0003121_genomic_imprinting1.05730209
94MP0006276_abnormal_autonomic_nervous1.04870104
95MP0000647_abnormal_sebaceous_gland1.04748050
96MP0000604_amyloidosis1.04488325
97MP0004381_abnormal_hair_follicle1.04125830
98MP0002066_abnormal_motor_capabilities/c1.03252703
99MP0005167_abnormal_blood-brain_barrier1.02222607
100MP0001929_abnormal_gametogenesis1.02002584
101MP0008789_abnormal_olfactory_epithelium1.01679058
102MP0005332_abnormal_amino_acid1.01451333
103MP0002229_neurodegeneration1.01372059
104MP0002295_abnormal_pulmonary_circulatio1.00419663
105MP0005395_other_phenotype1.00380296
106MP0001177_atelectasis0.99942164
107MP0005636_abnormal_mineral_homeostasis0.99809086
108MP0001944_abnormal_pancreas_morphology0.98829945
109MP0005058_abnormal_lysosome_morphology0.98687219
110MP0003632_abnormal_nervous_system0.98490252
111MP0000003_abnormal_adipose_tissue0.98423028
112MP0005408_hypopigmentation0.96376928
113MP0003959_abnormal_lean_body0.95685649
114MP0002822_catalepsy0.94995696
115MP0002693_abnormal_pancreas_physiology0.94764640
116MP0000955_abnormal_spinal_cord0.94611597
117MP0000538_abnormal_urinary_bladder0.91087606
118MP0003453_abnormal_keratinocyte_physiol0.91075798
119MP0002882_abnormal_neuron_morphology0.90347882
120* MP0008872_abnormal_physiological_respon0.89318363
121MP0002184_abnormal_innervation0.88249641
122MP0002118_abnormal_lipid_homeostasis0.87031105
123MP0003011_delayed_dark_adaptation0.86379839
124MP0002090_abnormal_vision0.86118204
125MP0001485_abnormal_pinna_reflex0.85803045
126MP0002332_abnormal_exercise_endurance0.85776269
127MP0000569_abnormal_digit_pigmentation0.84835555
128MP0000230_abnormal_systemic_arterial0.84728653
129MP0005535_abnormal_body_temperature0.84114900
130MP0000383_abnormal_hair_follicle0.83371701
131MP0000639_abnormal_adrenal_gland0.82600818
132MP0005499_abnormal_olfactory_system0.82173219
133MP0005394_taste/olfaction_phenotype0.82173219
134MP0009780_abnormal_chondrocyte_physiolo0.81284433
135MP0003724_increased_susceptibility_to0.80666509
136MP0002078_abnormal_glucose_homeostasis0.79706927
137MP0003828_pulmonary_edema0.78138865
138MP0002160_abnormal_reproductive_system0.78138118
139MP0004134_abnormal_chest_morphology0.76602723
140MP0003879_abnormal_hair_cell0.76384044
141MP0000026_abnormal_inner_ear0.74789626
142MP0002210_abnormal_sex_determination0.74064552
143MP0002136_abnormal_kidney_physiology0.73503665
144MP0005551_abnormal_eye_electrophysiolog0.72317522
145MP0005164_abnormal_response_to0.71745215
146MP0001963_abnormal_hearing_physiology0.71368588
147MP0005195_abnormal_posterior_eye0.71146519
148MP0003122_maternal_imprinting0.70782668
149MP0002970_abnormal_white_adipose0.70404257
150MP0002736_abnormal_nociception_after0.70168794
151MP0004811_abnormal_neuron_physiology0.70111887
152MP0002163_abnormal_gland_morphology0.69289632
153MP0008875_abnormal_xenobiotic_pharmacok0.68787192
154MP0003787_abnormal_imprinting0.68369602
155MP0000579_abnormal_nail_morphology0.68239603
156MP0005623_abnormal_meninges_morphology0.67004906
157MP0000537_abnormal_urethra_morphology0.66238882
158MP0002098_abnormal_vibrissa_morphology0.66057295
159MP0000613_abnormal_salivary_gland0.65686230
160MP0009765_abnormal_xenobiotic_induced0.65445705
161MP0002168_other_aberrant_phenotype0.63742553

Predicted human phenotypes

RankGene SetZ-score
1Peripheral hypomyelination (HP:0007182)6.64934964
2Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)5.33519163
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.10755455
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.10755455
5Axonal loss (HP:0003447)4.94426327
6Onion bulb formation (HP:0003383)4.59020837
7Neurofibrillary tangles (HP:0002185)4.49370838
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.36200181
9Peripheral demyelination (HP:0011096)4.23562953
10Myokymia (HP:0002411)4.11706626
11Progressive cerebellar ataxia (HP:0002073)4.06287472
12Segmental peripheral demyelination/remyelination (HP:0003481)3.90730994
13Abnormality of the corticospinal tract (HP:0002492)3.86807330
14Hyperaldosteronism (HP:0000859)3.83878435
15Focal motor seizures (HP:0011153)3.76761564
16Alacrima (HP:0000522)3.76133761
17Medial flaring of the eyebrow (HP:0010747)3.75261090
18Clumsiness (HP:0002312)3.73704817
19Abnormality of chloride homeostasis (HP:0011422)3.60999261
20Neoplasm of the adrenal cortex (HP:0100641)3.57716112
21Bilateral microphthalmos (HP:0007633)3.49345511
22Prostate neoplasm (HP:0100787)3.39931621
23Cerebral inclusion bodies (HP:0100314)3.37484372
24Bony spicule pigmentary retinopathy (HP:0007737)3.37061066
25Aplasia/Hypoplasia of the fovea (HP:0008060)3.34237561
26Hypoplasia of the fovea (HP:0007750)3.34237561
27Congenital sensorineural hearing impairment (HP:0008527)3.30244338
28Parakeratosis (HP:0001036)3.30227036
29Abnormal auditory evoked potentials (HP:0006958)3.29191373
30Genital tract atresia (HP:0001827)3.22287473
31Vaginal atresia (HP:0000148)3.21140334
32Spastic gait (HP:0002064)3.15184042
33Abnormal rod and cone electroretinograms (HP:0008323)3.10527694
34Hyperkalemia (HP:0002153)3.09404714
35Gait imbalance (HP:0002141)3.08823878
36Attenuation of retinal blood vessels (HP:0007843)3.07330235
37Aplasia involving bones of the upper limbs (HP:0009823)3.05638203
38Aplasia of the phalanges of the hand (HP:0009802)3.05638203
39Aplasia involving bones of the extremities (HP:0009825)3.05638203
40Congenital primary aphakia (HP:0007707)3.03013384
41Abnormality of the prostate (HP:0008775)3.01509655
42Renal Fanconi syndrome (HP:0001994)3.00882402
43Prolonged partial thromboplastin time (HP:0003645)2.99359668
44Focal seizures (HP:0007359)2.98203613
45Neuroendocrine neoplasm (HP:0100634)2.91665207
46Confusion (HP:0001289)2.91535661
47Cerebral hypomyelination (HP:0006808)2.90879899
48Decreased motor nerve conduction velocity (HP:0003431)2.83214869
49Genetic anticipation (HP:0003743)2.81861147
50Abnormality of the intrinsic pathway (HP:0010989)2.80300202
51Diaphragmatic weakness (HP:0009113)2.78968974
52Poor coordination (HP:0002370)2.78576592
53Pheochromocytoma (HP:0002666)2.77851376
54Protruding tongue (HP:0010808)2.77087177
55Hyperventilation (HP:0002883)2.72549526
56Metabolic alkalosis (HP:0200114)2.71770183
57Exotropia (HP:0000577)2.71277666
58Short tibia (HP:0005736)2.69627977
59Blue irides (HP:0000635)2.68127608
60Nephrogenic diabetes insipidus (HP:0009806)2.67210304
61Mutism (HP:0002300)2.61491585
62Abnormality of the renal cortex (HP:0011035)2.61323294
63Generalized tonic-clonic seizures (HP:0002069)2.60498412
64Scanning speech (HP:0002168)2.60318164
65Osteomalacia (HP:0002749)2.59243826
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.57781956
67White forelock (HP:0002211)2.57518248
68Decreased lacrimation (HP:0000633)2.52899131
69Abnormality of vitamin metabolism (HP:0100508)2.52406844
70Supranuclear gaze palsy (HP:0000605)2.52359370
71Muscle fiber splitting (HP:0003555)2.51097945
72Hypothermia (HP:0002045)2.49503562
73Megalencephaly (HP:0001355)2.48247841
74Abnormality of potassium homeostasis (HP:0011042)2.47753652
75Stridor (HP:0010307)2.45567340
76Absent speech (HP:0001344)2.45416687
77Tubulointerstitial fibrosis (HP:0005576)2.45222793
78Pendular nystagmus (HP:0012043)2.42513390
79Dialeptic seizures (HP:0011146)2.42372316
80Prolonged neonatal jaundice (HP:0006579)2.41601281
81Opisthotonus (HP:0002179)2.41570967
82Foot dorsiflexor weakness (HP:0009027)2.41475789
83Renal salt wasting (HP:0000127)2.41168190
84Patchy hypopigmentation of hair (HP:0011365)2.41003125
85Broad alveolar ridges (HP:0000187)2.38286586
86Obstructive sleep apnea (HP:0002870)2.38190499
87Dysmetria (HP:0001310)2.38056902
88Hypoproteinemia (HP:0003075)2.34586008
89Cerebral hemorrhage (HP:0001342)2.32264352
90Abnormal albumin level (HP:0012116)2.31689735
91Hypoalbuminemia (HP:0003073)2.31689735
92Tubulointerstitial abnormality (HP:0001969)2.31336427
93Torticollis (HP:0000473)2.30415370
94Abnormality of the fovea (HP:0000493)2.30317789
95Increased cerebral lipofuscin (HP:0011813)2.28145554
96Abnormality of the nasal septum (HP:0000419)2.27650160
97Ureteral obstruction (HP:0006000)2.26681250
98Hepatosplenomegaly (HP:0001433)2.26675575
99Reduced antithrombin III activity (HP:0001976)2.25873328
100Ankle clonus (HP:0011448)2.25116032
101Episodic fever (HP:0001954)2.23758435
102Colon cancer (HP:0003003)2.22836245
103Leukodystrophy (HP:0002415)2.21688818
104Tubulointerstitial nephritis (HP:0001970)2.19990033
105Aplasia/Hypoplasia of the tibia (HP:0005772)2.18896128
106Termporal pattern (HP:0011008)2.18843414
107Insidious onset (HP:0003587)2.18843414
108Pancreatic cysts (HP:0001737)2.18609282
109Hyponatremia (HP:0002902)2.16288972
110Abnormality of renal resorption (HP:0011038)2.16068142
111Hyperactive renin-angiotensin system (HP:0000841)2.15887695
112Abnormality of the foot musculature (HP:0001436)2.15173877
113Broad-based gait (HP:0002136)2.14852638
114Truncal ataxia (HP:0002078)2.13376255
115Abnormality of vitamin B metabolism (HP:0004340)2.13350194
116Small hand (HP:0200055)2.12811012
117Abnormality of the renal medulla (HP:0100957)2.11853825
118Choreoathetosis (HP:0001266)2.11797964
119Abnormality of midbrain morphology (HP:0002418)2.11383803
120Molar tooth sign on MRI (HP:0002419)2.11383803
121Limb dystonia (HP:0002451)2.11037968
122Increased hepatocellular lipid droplets (HP:0006565)2.09834225
123Thoracolumbar scoliosis (HP:0002944)2.08491680
124Conical tooth (HP:0000698)2.08236368
125Decreased circulating renin level (HP:0003351)2.07841499
126Birth length less than 3rd percentile (HP:0003561)2.05451137
127Congenital, generalized hypertrichosis (HP:0004540)2.01980622
1283-Methylglutaconic aciduria (HP:0003535)2.00781250
129Sleep apnea (HP:0010535)2.00432267
130Lower limb muscle weakness (HP:0007340)1.99613265
131Generalized hypopigmentation of hair (HP:0011358)1.99316522
132Cutaneous photosensitivity (HP:0000992)1.98533426
133Hypophosphatemic rickets (HP:0004912)1.98437043
134Split foot (HP:0001839)1.98125507
135Cystic liver disease (HP:0006706)1.97940585
136Large for gestational age (HP:0001520)1.97372248
137Lipid accumulation in hepatocytes (HP:0006561)1.97018063
138Hyporeflexia of lower limbs (HP:0002600)1.96993340
139Aplasia/Hypoplasia of the macula (HP:0008059)1.96190722
140Hyperphosphaturia (HP:0003109)1.95580953
141Thickened helices (HP:0000391)1.95194162
142Abnormality of macrophages (HP:0004311)1.94924862
143Hypokalemic alkalosis (HP:0001949)1.93058670
144CNS hypomyelination (HP:0003429)1.93019959
145Hypokalemia (HP:0002900)1.92811571
146Polyuria (HP:0000103)1.92181395
147Anxiety (HP:0000739)1.91965715
148Conjugated hyperbilirubinemia (HP:0002908)1.90687043
149Infantile muscular hypotonia (HP:0008947)1.90512028
150Neoplasm of the peripheral nervous system (HP:0100007)1.90207139
151Ureteral stenosis (HP:0000071)1.89954215
152Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89193928
153Intellectual disability, progressive (HP:0006887)1.88912869
154Oligodontia (HP:0000677)1.88728557
155Gaze-evoked nystagmus (HP:0000640)1.87882354
156Hammertoe (HP:0001765)1.87064772
157Aplasia/Hypoplasia of the lens (HP:0008063)1.86859949
158Abnormality of male internal genitalia (HP:0000022)1.85021705
159Intellectual disability, moderate (HP:0002342)1.84488907
160Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83823570
161Abnormal protein N-linked glycosylation (HP:0012347)1.83823570
162Abnormal protein glycosylation (HP:0012346)1.83823570
163Abnormal glycosylation (HP:0012345)1.83823570
164Xerostomia (HP:0000217)1.82773672
165Type II lissencephaly (HP:0007260)1.82300394
166Proximal tubulopathy (HP:0000114)1.82298573
167Tubular atrophy (HP:0000092)1.82150978
168Joint hemorrhage (HP:0005261)1.81872972
169Progressive neurologic deterioration (HP:0002344)1.81627335
170Generalized myoclonic seizures (HP:0002123)1.81625095
171Aplasia/Hypoplasia affecting the retina (HP:0008061)1.81440018
172Dynein arm defect of respiratory motile cilia (HP:0012255)1.81379385
173Absent/shortened dynein arms (HP:0200106)1.81379385
174Stomach cancer (HP:0012126)1.81264394
175Fair hair (HP:0002286)1.80969098
176Retinitis pigmentosa (HP:0000510)1.80469953
177Distal sensory impairment (HP:0002936)1.80293186
178Abnormality of salivation (HP:0100755)1.79817402
179Intention tremor (HP:0002080)1.79272115
180Abnormal ciliary motility (HP:0012262)1.78907284
181Drooling (HP:0002307)1.78339268
182Excessive salivation (HP:0003781)1.78339268
183Insulin-resistant diabetes mellitus (HP:0000831)1.77288063
184Abnormal gallbladder physiology (HP:0012438)1.76741950
185Cholecystitis (HP:0001082)1.76741950
186Hemiparesis (HP:0001269)1.75596285
187Morphological abnormality of the inner ear (HP:0011390)1.74968598
188Sensory axonal neuropathy (HP:0003390)1.74733762
189Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74543260
190Neoplasm of the adrenal gland (HP:0100631)1.74460141
191Intrahepatic cholestasis (HP:0001406)1.74244827
192Abnormal hair whorl (HP:0010721)1.74081422
193Visual hallucinations (HP:0002367)1.71428934
194Morphological abnormality of the pyramidal tract (HP:0002062)1.71057920
195Focal dystonia (HP:0004373)1.70622953
196Spastic paraparesis (HP:0002313)1.70597798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB15.50179742
2TAF15.08920830
3VRK24.63328165
4STK394.59752275
5NEK24.49476317
6SMG14.29732005
7MET3.62764171
8FGR3.54074041
9CAMKK23.44460281
10EPHB13.40201283
11INSRR3.22777182
12NUAK13.17995944
13OXSR13.17203281
14CASK3.00074281
15PKN12.99789352
16CAMK1D2.65609695
17DMPK2.42196957
18GRK72.32189792
19CAMK1G2.08398374
20NEK61.97583443
21UHMK11.89351889
22CSF1R1.87567571
23ADRBK21.80262649
24WNK31.80115032
25EPHA21.77474016
26FGFR21.75245594
27CAMK2B1.74283979
28MAPKAPK51.71138637
29MAP3K41.67114610
30MARK11.66105994
31PAK61.65454523
32PTK2B1.65130989
33WNK41.59635646
34NTRK11.57215433
35MAP3K61.55997222
36MAP3K131.55266562
37LMTK21.51836102
38BMX1.49131530
39PHKG11.48475733
40PHKG21.48475733
41WNK11.41785715
42MST1R1.37380064
43ROCK21.37097387
44MAP3K141.33589658
45PINK11.33359149
46BCR1.32256595
47CHUK1.28847259
48VRK11.25753010
49CDK51.24547462
50CDK191.20995014
51CAMK2A1.20680827
52RPS6KB21.19305250
53CAMK2D1.18449328
54DYRK31.16435342
55PAK31.11599908
56RIPK41.08919850
57CAMK2G1.08569049
58NTRK21.08029790
59LATS11.05845033
60BMPR20.99024366
61EPHA40.98828292
62NTRK30.97413335
63PIK3CG0.97321797
64CAMK10.97239947
65DAPK30.95847455
66MAP2K70.95465894
67MAP3K90.92572665
68PLK40.92325886
69PRKCH0.90762266
70MAP3K70.89739200
71GRK10.88744633
72PRKAA20.86982661
73DYRK20.83778571
74KSR20.83769925
75PTK20.83401423
76RPS6KA50.79621257
77ACVR1B0.78920990
78CAMKK10.78539403
79SGK2230.78201511
80SGK4940.78201511
81MAP3K20.76321198
82GRK50.75962469
83EIF2AK30.75156168
84HIPK20.74236246
85LIMK10.73411476
86ADRBK10.71555533
87ARAF0.71115536
88TGFBR20.70741878
89PRKCE0.68088514
90CDK90.68053377
91TESK20.67314207
92PDGFRB0.67028840
93CDK150.64562575
94CAMK40.64277746
95PDPK10.64257147
96PRKCQ0.63266135
97DYRK1A0.62835891
98TRPM70.62233286
99MINK10.62146409
100CDK180.61597659
101MELK0.61300697
102CSNK1G30.60972274
103FES0.60961870
104CDK11A0.60536551
105PRKD10.58477697
106MARK20.58407727
107YES10.58066472
108MAP2K20.57942863
109PBK0.57570873
110RAF10.55662390
111FRK0.55157451
112GSK3A0.54141495
113PRKCG0.53861117
114CDK140.53558364
115STK38L0.51947487
116EPHB20.49928214
117PRKG10.49724491
118SGK20.49707386
119MAPK130.49182814
120CSNK1A1L0.49010231
121MST40.47803472
122MKNK10.46632998
123CSNK1G10.46422069
124FER0.46305524
125FYN0.44137676
126PRKACB0.43729177
127PLK20.43706050
128EGFR0.43026361
129SRC0.41465577
130PAK10.41294418
131PNCK0.40629612
132EIF2AK20.40525974
133PDK10.40267028
134NME10.39816933
135BMPR1B0.39700102
136CSNK1A10.39333948
137IRAK30.38405215
138ROCK10.38334592
139BRD40.38282953
140INSR0.36676048
141ERBB40.36544934
142CSNK1G20.36278303
143LRRK20.34768538
144TNIK0.34741145
145PIK3CA0.34697962
146PRKG20.33755991
147MKNK20.33313567
148CSNK1E0.33087408
149RET0.32862173
150ILK0.32714010
151ALK0.32382792
152ICK0.31341436
153MAP4K20.29911760
154PRKCI0.29195959
155DAPK10.28001588
156SGK10.26899069
157MAPK40.25777253
158PLK30.22396796
159PAK20.22105447
160TIE10.20695334
161PRKAA10.19549117
162ERN10.18048329
163CHEK20.17451742
164MAP2K40.15503448
165STK240.14192149
166PRKCA0.13533314
167MAP2K60.12536029

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.90303416
2Fatty acid elongation_Homo sapiens_hsa000623.43073486
3Steroid biosynthesis_Homo sapiens_hsa001003.12754293
4Histidine metabolism_Homo sapiens_hsa003402.82648631
5Folate biosynthesis_Homo sapiens_hsa007902.74401482
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.64410554
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.63182207
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61489340
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.59691772
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.53909179
11Ether lipid metabolism_Homo sapiens_hsa005652.19517473
12Vitamin B6 metabolism_Homo sapiens_hsa007502.02952322
13GABAergic synapse_Homo sapiens_hsa047271.97456370
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94818955
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.89620502
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84695697
17Caffeine metabolism_Homo sapiens_hsa002321.83678078
18Tryptophan metabolism_Homo sapiens_hsa003801.82014510
19Taste transduction_Homo sapiens_hsa047421.78327666
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.72628903
21Renin-angiotensin system_Homo sapiens_hsa046141.71825275
22Glutamatergic synapse_Homo sapiens_hsa047241.70931488
23Asthma_Homo sapiens_hsa053101.66604705
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64483465
25Retinol metabolism_Homo sapiens_hsa008301.63707821
26Circadian entrainment_Homo sapiens_hsa047131.58641932
27Morphine addiction_Homo sapiens_hsa050321.56154903
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47925604
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47774590
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.47105215
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46876111
32Phenylalanine metabolism_Homo sapiens_hsa003601.44826697
33Basal transcription factors_Homo sapiens_hsa030221.42657030
34Collecting duct acid secretion_Homo sapiens_hsa049661.40178231
35Fatty acid degradation_Homo sapiens_hsa000711.38167973
36Tyrosine metabolism_Homo sapiens_hsa003501.37685084
37Protein export_Homo sapiens_hsa030601.37473698
38Nicotine addiction_Homo sapiens_hsa050331.37106180
39Vibrio cholerae infection_Homo sapiens_hsa051101.32872158
40Mineral absorption_Homo sapiens_hsa049781.32193003
41Nitrogen metabolism_Homo sapiens_hsa009101.31734579
42Ribosome_Homo sapiens_hsa030101.29984076
43Salivary secretion_Homo sapiens_hsa049701.27649424
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27358830
45Propanoate metabolism_Homo sapiens_hsa006401.25725336
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22124292
47Serotonergic synapse_Homo sapiens_hsa047261.19561115
48ABC transporters_Homo sapiens_hsa020101.19360198
49Synaptic vesicle cycle_Homo sapiens_hsa047211.18130795
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18062860
51Long-term depression_Homo sapiens_hsa047301.17857844
52Amphetamine addiction_Homo sapiens_hsa050311.15866807
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14933930
54Renal cell carcinoma_Homo sapiens_hsa052111.14469625
55Axon guidance_Homo sapiens_hsa043601.13580173
56Gastric acid secretion_Homo sapiens_hsa049711.12572503
57Selenocompound metabolism_Homo sapiens_hsa004501.10887520
58Cocaine addiction_Homo sapiens_hsa050301.10512108
59Oxidative phosphorylation_Homo sapiens_hsa001901.09290817
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06850981
61Arginine and proline metabolism_Homo sapiens_hsa003301.04664366
62Starch and sucrose metabolism_Homo sapiens_hsa005001.03063532
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02956576
64Sulfur relay system_Homo sapiens_hsa041221.02275475
65Glycerolipid metabolism_Homo sapiens_hsa005611.01793248
66Arachidonic acid metabolism_Homo sapiens_hsa005901.01486799
67Homologous recombination_Homo sapiens_hsa034401.00965856
68Arginine biosynthesis_Homo sapiens_hsa002201.00141205
69Sulfur metabolism_Homo sapiens_hsa009200.99627833
70Phagosome_Homo sapiens_hsa041450.99575581
71Renin secretion_Homo sapiens_hsa049240.97983038
72Cardiac muscle contraction_Homo sapiens_hsa042600.96170593
73Lysine degradation_Homo sapiens_hsa003100.92514478
74Butanoate metabolism_Homo sapiens_hsa006500.90759851
75Rheumatoid arthritis_Homo sapiens_hsa053230.90419214
76Cholinergic synapse_Homo sapiens_hsa047250.88040906
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86445801
78Dopaminergic synapse_Homo sapiens_hsa047280.86126933
79Olfactory transduction_Homo sapiens_hsa047400.85817532
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85268259
81Pyruvate metabolism_Homo sapiens_hsa006200.84671782
82Long-term potentiation_Homo sapiens_hsa047200.83911254
83African trypanosomiasis_Homo sapiens_hsa051430.82053998
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.80778975
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80613172
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79972790
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.79402300
88Alzheimers disease_Homo sapiens_hsa050100.78942915
89Glucagon signaling pathway_Homo sapiens_hsa049220.78619304
90Fat digestion and absorption_Homo sapiens_hsa049750.77223655
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76930565
92beta-Alanine metabolism_Homo sapiens_hsa004100.76177739
93Huntingtons disease_Homo sapiens_hsa050160.75204937
94Complement and coagulation cascades_Homo sapiens_hsa046100.74933994
95Fatty acid metabolism_Homo sapiens_hsa012120.74403373
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74007159
97cAMP signaling pathway_Homo sapiens_hsa040240.73310298
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.70621435
99Parkinsons disease_Homo sapiens_hsa050120.69355039
100Ras signaling pathway_Homo sapiens_hsa040140.68552178
101Staphylococcus aureus infection_Homo sapiens_hsa051500.68375824
102Chemokine signaling pathway_Homo sapiens_hsa040620.67725706
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67705667
104Dorso-ventral axis formation_Homo sapiens_hsa043200.67069218
105Glutathione metabolism_Homo sapiens_hsa004800.64603411
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64494726
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62814343
108Gap junction_Homo sapiens_hsa045400.61769737
109Linoleic acid metabolism_Homo sapiens_hsa005910.61758599
110Insulin secretion_Homo sapiens_hsa049110.61051737
111Salmonella infection_Homo sapiens_hsa051320.60564377
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.60072394
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60004967
114Autoimmune thyroid disease_Homo sapiens_hsa053200.58033964
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57521761
116Graft-versus-host disease_Homo sapiens_hsa053320.57505178
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57270541
118Pancreatic secretion_Homo sapiens_hsa049720.57002091
119Oxytocin signaling pathway_Homo sapiens_hsa049210.56474920
120Ovarian steroidogenesis_Homo sapiens_hsa049130.56404921
121Chemical carcinogenesis_Homo sapiens_hsa052040.56379934
122Allograft rejection_Homo sapiens_hsa053300.55801473
123Metabolic pathways_Homo sapiens_hsa011000.54813872
124Sphingolipid metabolism_Homo sapiens_hsa006000.54518067
125Lysosome_Homo sapiens_hsa041420.54019129
126Regulation of autophagy_Homo sapiens_hsa041400.53661607
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53270667
128Thyroid hormone synthesis_Homo sapiens_hsa049180.51564375
129Calcium signaling pathway_Homo sapiens_hsa040200.50871078
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.50672028
131Phototransduction_Homo sapiens_hsa047440.50174278
132VEGF signaling pathway_Homo sapiens_hsa043700.49721046
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47810725
134Prion diseases_Homo sapiens_hsa050200.46957705
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46937976
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46633573
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45327511
138Tight junction_Homo sapiens_hsa045300.44928897
139Amoebiasis_Homo sapiens_hsa051460.43942031
140MAPK signaling pathway_Homo sapiens_hsa040100.43770398
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.41390861
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40563665
143Circadian rhythm_Homo sapiens_hsa047100.40093339
144Protein digestion and absorption_Homo sapiens_hsa049740.39475502
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39204233
146Peroxisome_Homo sapiens_hsa041460.38373005
147Melanoma_Homo sapiens_hsa052180.37213437
148PPAR signaling pathway_Homo sapiens_hsa033200.36718469
149N-Glycan biosynthesis_Homo sapiens_hsa005100.36073213
150Fatty acid biosynthesis_Homo sapiens_hsa000610.35453200
151Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33583706

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