NPTX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84487901
2synaptic vesicle maturation (GO:0016188)5.63642327
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.26042082
4glutamate secretion (GO:0014047)5.14376000
5synaptic vesicle exocytosis (GO:0016079)4.94902673
6locomotory exploration behavior (GO:0035641)4.57383914
7protein localization to synapse (GO:0035418)4.57198009
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.56807892
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.56553183
10vocalization behavior (GO:0071625)4.47065215
11proline transport (GO:0015824)4.43151081
12regulation of synaptic vesicle exocytosis (GO:2000300)4.40881884
13response to gravity (GO:0009629)4.39430795
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.22068856
15cell migration in hindbrain (GO:0021535)4.09793725
16pyrimidine nucleobase catabolic process (GO:0006208)4.04934704
17layer formation in cerebral cortex (GO:0021819)4.04154286
18glucocorticoid biosynthetic process (GO:0006704)3.98589682
19regulation of neuronal synaptic plasticity (GO:0048168)3.98075461
20regulation of synaptic vesicle transport (GO:1902803)3.94566481
21neuronal action potential propagation (GO:0019227)3.91086197
22synaptic vesicle endocytosis (GO:0048488)3.89188488
23regulation of glutamate receptor signaling pathway (GO:1900449)3.87941211
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.82546766
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.74240377
26negative regulation of cytosolic calcium ion concentration (GO:0051481)3.71530996
27synaptic transmission, glutamatergic (GO:0035249)3.67969557
28dendritic spine morphogenesis (GO:0060997)3.66737462
29nucleobase catabolic process (GO:0046113)3.63968615
30negative regulation of hormone biosynthetic process (GO:0032353)3.62688442
31positive regulation of synapse maturation (GO:0090129)3.61881471
32neuromuscular process controlling balance (GO:0050885)3.61868667
33endocrine pancreas development (GO:0031018)3.60403046
34glutamate receptor signaling pathway (GO:0007215)3.57781819
35positive regulation of nitric-oxide synthase activity (GO:0051000)3.56299284
36neuron cell-cell adhesion (GO:0007158)3.54076592
37presynaptic membrane organization (GO:0097090)3.52260519
38exploration behavior (GO:0035640)3.50583869
39negative regulation of gluconeogenesis (GO:0045721)3.48370178
40glucocorticoid metabolic process (GO:0008211)3.46752313
41embryonic retina morphogenesis in camera-type eye (GO:0060059)3.41600722
42positive regulation of glycolytic process (GO:0045821)3.39982449
43postsynaptic membrane organization (GO:0001941)3.39160980
44neurotransmitter secretion (GO:0007269)3.37285781
45neuron recognition (GO:0008038)3.36848373
46type B pancreatic cell development (GO:0003323)3.36466115
47innervation (GO:0060384)3.36440396
48neuromuscular process controlling posture (GO:0050884)3.35310752
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35017445
50axonal fasciculation (GO:0007413)3.32329718
51presynaptic membrane assembly (GO:0097105)3.30710959
52regulation of synaptic plasticity (GO:0048167)3.28762220
53regulation of cAMP-dependent protein kinase activity (GO:2000479)3.27874654
54positive regulation of dendritic spine morphogenesis (GO:0061003)3.27019898
55cellular potassium ion homeostasis (GO:0030007)3.26903655
56neuron-neuron synaptic transmission (GO:0007270)3.26739271
57regulation of synapse structural plasticity (GO:0051823)3.24388487
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22436098
59dendritic spine organization (GO:0097061)3.20969228
60regulation of dendritic spine morphogenesis (GO:0061001)3.19738442
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.15344255
62chemosensory behavior (GO:0007635)3.14562759
63regulation of postsynaptic membrane potential (GO:0060078)3.14299040
64androgen biosynthetic process (GO:0006702)3.13179626
65cerebellar granule cell differentiation (GO:0021707)3.12768088
66sodium ion export (GO:0071436)3.12742516
67neuromuscular process (GO:0050905)3.08994145
68behavioral fear response (GO:0001662)3.06925063
69behavioral defense response (GO:0002209)3.06925063
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04688601
71negative regulation of hormone metabolic process (GO:0032351)3.01996990
72long-term memory (GO:0007616)3.01524322
73positive regulation of neurotransmitter transport (GO:0051590)3.00314378
74paraxial mesoderm development (GO:0048339)2.98701991
75insulin secretion (GO:0030073)2.94173873
76transmission of nerve impulse (GO:0019226)2.93827565
77cellular response to vitamin D (GO:0071305)2.93450690
78regulation of neurotransmitter secretion (GO:0046928)2.93335412
79regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.92195860
80activation of protein kinase A activity (GO:0034199)2.91358053
81membrane depolarization during action potential (GO:0086010)2.90834821
82vesicle transport along microtubule (GO:0047496)2.90816493
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88227888
84lactate metabolic process (GO:0006089)2.87607033
85negative regulation of dendrite development (GO:2000171)2.85933091
86nitric oxide mediated signal transduction (GO:0007263)2.84448762
87positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82066450
88cerebellar Purkinje cell differentiation (GO:0021702)2.81641699
89regulation of clathrin-mediated endocytosis (GO:2000369)2.81191688
90regulation of glucokinase activity (GO:0033131)2.81096339
91regulation of hexokinase activity (GO:1903299)2.81096339
92positive regulation of membrane potential (GO:0045838)2.80788772
93regulation of vesicle fusion (GO:0031338)2.79398385
94negative regulation of glycogen metabolic process (GO:0070874)2.78193104
95fear response (GO:0042596)2.77205890
96neurotransmitter transport (GO:0006836)2.77195521
97cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.76569367
98gamma-aminobutyric acid transport (GO:0015812)2.75912711
99cell communication by electrical coupling (GO:0010644)2.75141134
100glandular epithelial cell differentiation (GO:0002067)2.75102325
101detection of calcium ion (GO:0005513)2.74652835
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.74398353
103regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.74173599
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.73287679
105cerebellar Purkinje cell layer development (GO:0021680)2.72863782
106central nervous system projection neuron axonogenesis (GO:0021952)2.72296678
107establishment of monopolar cell polarity (GO:0061162)2.71732779
108establishment or maintenance of monopolar cell polarity (GO:0061339)2.71732779
109membrane depolarization (GO:0051899)2.71258309
110positive regulation of respiratory burst (GO:0060267)2.71149592
111establishment of apical/basal cell polarity (GO:0035089)2.69243840
112dendrite morphogenesis (GO:0048813)2.68599224
113histone H4-K12 acetylation (GO:0043983)2.67603043
114organelle transport along microtubule (GO:0072384)2.66287769
115glycine transport (GO:0015816)2.66003079
116negative regulation of microtubule polymerization (GO:0031115)2.65786092
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65415722
118positive regulation of dendritic spine development (GO:0060999)2.65062326
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.64880305
120mating behavior (GO:0007617)2.63138033
121membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63118408
122regulation of synapse maturation (GO:0090128)2.63028598
123axon ensheathment in central nervous system (GO:0032291)2.63026526
124central nervous system myelination (GO:0022010)2.63026526
125neuronal ion channel clustering (GO:0045161)2.62895924
126learning (GO:0007612)2.61633586
127kidney morphogenesis (GO:0060993)2.61554941
128* synaptic transmission (GO:0007268)2.61085020
129regulation of neurotransmitter transport (GO:0051588)2.60848438
130regulation of early endosome to late endosome transport (GO:2000641)2.60638256
131positive regulation of peptide secretion (GO:0002793)2.60324456
132retinal ganglion cell axon guidance (GO:0031290)2.60232853
133regulation of type B pancreatic cell apoptotic process (GO:2000674)2.59339204
134negative regulation of Ras GTPase activity (GO:0034261)2.59137977
135regulation of calcium ion-dependent exocytosis (GO:0017158)2.58667038
136urinary tract smooth muscle contraction (GO:0014848)2.58473937
137regulation of synaptic transmission (GO:0050804)2.57936699
138G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.57920999
139positive regulation of neurotransmitter secretion (GO:0001956)2.57826366
140long-term synaptic potentiation (GO:0060291)2.57422429
141cAMP-mediated signaling (GO:0019933)2.55941756
142startle response (GO:0001964)2.55413506
143negative regulation of dendrite morphogenesis (GO:0050774)2.55079471
144negative regulation of amino acid transport (GO:0051956)2.54849682
145positive regulation of glycogen biosynthetic process (GO:0045725)2.54104048
146auditory behavior (GO:0031223)2.52957411
147negative regulation of catecholamine secretion (GO:0033604)2.52687031
148positive regulation of peptide hormone secretion (GO:0090277)2.52516093
149negative regulation of acute inflammatory response (GO:0002674)2.51651865
150regulation of axon extension involved in axon guidance (GO:0048841)2.50451288
151regulation of male gonad development (GO:2000018)2.49845833
152negative regulation of protein oligomerization (GO:0032460)2.48536103
153response to leptin (GO:0044321)2.47914220
154negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47563099
155ganglion development (GO:0061548)2.46124158
156regulation of neuron migration (GO:2001222)2.42257401
157regulation of feeding behavior (GO:0060259)2.41063274
158positive regulation of growth hormone secretion (GO:0060124)2.40861994
159regulation of insulin secretion (GO:0050796)2.39790692
160positive regulation of glycogen metabolic process (GO:0070875)2.39505568
161response to auditory stimulus (GO:0010996)2.38963563
162adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.38462217
163cerebellum development (GO:0021549)2.37756168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59828198
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.80101367
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.70579073
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.66036903
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.63384747
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.58871596
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.57774409
8ERG_21242973_ChIP-ChIP_JURKAT_Human2.50570774
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.48915323
10* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38525182
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35921995
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.32004162
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.32004162
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.32004162
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31268918
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26839270
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26839270
18ZFP281_18757296_ChIP-ChIP_E14_Mouse2.23744664
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.18421176
20* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09483091
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07117152
22GBX2_23144817_ChIP-Seq_PC3_Human2.06409474
23* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.03025435
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.00185827
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98935512
26* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.98546007
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.98483146
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95125922
29DROSHA_22980978_ChIP-Seq_HELA_Human1.93837356
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.91084280
31* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.86277281
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83680556
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83191330
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.82577844
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.82492354
36* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81811936
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80933911
38SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.79313078
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77803964
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72871955
41* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72393426
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72349091
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70228862
44* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70000183
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69528501
46KDM2B_26808549_Chip-Seq_K562_Human1.69229475
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.67747175
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63477128
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.63115470
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.60466074
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.58009945
52* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.55116826
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47846813
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.46568282
55* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46278785
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46022178
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44501998
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41018352
59ZNF263_19887448_ChIP-Seq_K562_Human1.40998841
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36384273
61POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32755191
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32090304
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.30782215
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28740074
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27538564
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27535582
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.26827819
68TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26126903
69P300_19829295_ChIP-Seq_ESCs_Human1.25380517
70CTCF_27219007_Chip-Seq_Bcells_Human1.25246019
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22601253
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20726089
73* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19658254
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.19527531
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19320596
76* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.18660365
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17112479
78* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16068598
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15230890
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15208229
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14613076
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14234349
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13761403
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13697372
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13294914
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.13046603
87* AR_25329375_ChIP-Seq_VCAP_Human1.12337670
88RNF2_27304074_Chip-Seq_NSC_Mouse1.12097907
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10146081
90AR_21572438_ChIP-Seq_LNCaP_Human1.09652328
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08308145
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08195481
93* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08165894
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07736186
95* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06650196
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06207724
97* NANOG_18555785_Chip-Seq_ESCs_Mouse1.05690027
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05453794
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05453794
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04020129
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.03752143
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02764391
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02428426
104TAF15_26573619_Chip-Seq_HEK293_Human1.01793871
105AR_19668381_ChIP-Seq_PC3_Human1.01012229
106WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98961426
107* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98556721
108LXR_22292898_ChIP-Seq_THP-1_Human0.96468446
109STAT3_23295773_ChIP-Seq_U87_Human0.96026384
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95816329
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95654028
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93978629
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93713064
114WT1_19549856_ChIP-ChIP_CCG9911_Human0.93494258
115* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93409967
116* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93371835
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92267816
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92155588
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90672159
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.90559358
121NANOG_18692474_ChIP-Seq_MESCs_Mouse0.90537915
122GATA1_26923725_Chip-Seq_HPCs_Mouse0.90358815
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89907507
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89377524
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89175817
126* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88933130
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88835742
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88647847
129P53_22387025_ChIP-Seq_ESCs_Mouse0.87695261
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87541690
131VDR_22108803_ChIP-Seq_LS180_Human0.87299280
132* SOX2_21211035_ChIP-Seq_LN229_Gbm0.86806279
133SMAD4_21799915_ChIP-Seq_A2780_Human0.86713788
134NANOG_16518401_ChIP-PET_MESCs_Mouse0.86580957
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86380378
136* RUNX2_22187159_ChIP-Seq_PCA_Human0.85928684
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.85048107
138* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84974341
139GF1B_26923725_Chip-Seq_HPCs_Mouse0.84746496
140CREB1_26743006_Chip-Seq_LNCaP_Human0.84419952
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84297492
142PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84150253
143AHR_22903824_ChIP-Seq_MCF-7_Human0.84032147
144TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83756220
145SMC4_20622854_ChIP-Seq_HELA_Human0.82815804
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82583827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.02384954
2MP0004270_analgesia3.64677958
3MP0003880_abnormal_central_pattern3.58922534
4MP0003635_abnormal_synaptic_transmissio3.45568605
5MP0001968_abnormal_touch/_nociception3.26896862
6MP0002653_abnormal_ependyma_morphology3.22265951
7* MP0002063_abnormal_learning/memory/cond2.94133386
8MP0002735_abnormal_chemical_nociception2.82623058
9MP0002736_abnormal_nociception_after2.65493848
10MP0004858_abnormal_nervous_system2.65311244
11MP0009745_abnormal_behavioral_response2.61012316
12MP0002734_abnormal_mechanical_nocicepti2.59194641
13MP0002733_abnormal_thermal_nociception2.47618843
14MP0002064_seizures2.43055537
15MP0002572_abnormal_emotion/affect_behav2.34323326
16MP0001970_abnormal_pain_threshold2.20208253
17MP0009046_muscle_twitch2.16783233
18MP0002272_abnormal_nervous_system2.07935013
19MP0000778_abnormal_nervous_system1.94184549
20MP0003283_abnormal_digestive_organ1.91089598
21MP0003121_genomic_imprinting1.87092858
22MP0001486_abnormal_startle_reflex1.87079801
23* MP0002184_abnormal_innervation1.83420310
24MP0002163_abnormal_gland_morphology1.73636715
25MP0004811_abnormal_neuron_physiology1.71730206
26MP0005423_abnormal_somatic_nervous1.70524347
27MP0001944_abnormal_pancreas_morphology1.67385570
28MP0006276_abnormal_autonomic_nervous1.65959411
29MP0001440_abnormal_grooming_behavior1.64492233
30MP0002067_abnormal_sensory_capabilities1.62240320
31MP0000955_abnormal_spinal_cord1.60888675
32MP0008004_abnormal_stomach_pH1.58986559
33MP0005394_taste/olfaction_phenotype1.56835121
34MP0005499_abnormal_olfactory_system1.56835121
35MP0003879_abnormal_hair_cell1.53772478
36MP0001501_abnormal_sleep_pattern1.52842086
37MP0003195_calcinosis1.52507115
38MP0003011_delayed_dark_adaptation1.51331330
39MP0005379_endocrine/exocrine_gland_phen1.48376320
40MP0002882_abnormal_neuron_morphology1.45619950
41MP0000462_abnormal_digestive_system1.41770914
42MP0001188_hyperpigmentation1.39635411
43MP0002557_abnormal_social/conspecific_i1.38615827
44MP0000639_abnormal_adrenal_gland1.34623439
45MP0003329_amyloid_beta_deposits1.34565294
46MP0003890_abnormal_embryonic-extraembry1.33493632
47MP0002638_abnormal_pupillary_reflex1.32969782
48MP0005645_abnormal_hypothalamus_physiol1.31344704
49MP0004885_abnormal_endolymph1.31000245
50MP0001984_abnormal_olfaction1.30832239
51MP0010234_abnormal_vibrissa_follicle1.28578267
52MP0002837_dystrophic_cardiac_calcinosis1.26101015
53MP0002751_abnormal_autonomic_nervous1.25016610
54MP0000013_abnormal_adipose_tissue1.24684847
55MP0002928_abnormal_bile_duct1.24419414
56MP0002066_abnormal_motor_capabilities/c1.23612665
57MP0008961_abnormal_basal_metabolism1.23412529
58MP0003119_abnormal_digestive_system1.22399883
59MP0002152_abnormal_brain_morphology1.21811337
60MP0002693_abnormal_pancreas_physiology1.20562013
61MP0006292_abnormal_olfactory_placode1.19057161
62MP0008877_abnormal_DNA_methylation1.18888764
63MP0003787_abnormal_imprinting1.17524334
64MP0004233_abnormal_muscle_weight1.16897593
65MP0004133_heterotaxia1.15373935
66MP0002909_abnormal_adrenal_gland1.14295723
67MP0001348_abnormal_lacrimal_gland1.13630421
68MP0003861_abnormal_nervous_system1.12126855
69MP0002876_abnormal_thyroid_physiology1.10669154
70MP0009780_abnormal_chondrocyte_physiolo1.08633403
71MP0002090_abnormal_vision1.08262500
72MP0001485_abnormal_pinna_reflex1.06230168
73MP0008569_lethality_at_weaning1.05082740
74MP0002822_catalepsy1.04957831
75MP0001502_abnormal_circadian_rhythm1.04596972
76MP0010030_abnormal_orbit_morphology1.04300000
77MP0006072_abnormal_retinal_apoptosis1.02710386
78MP0002752_abnormal_somatic_nervous1.02645772
79MP0002078_abnormal_glucose_homeostasis1.01448979
80MP0005386_behavior/neurological_phenoty1.01179587
81MP0004924_abnormal_behavior1.01179587
82MP0005220_abnormal_exocrine_pancreas0.95918397
83MP0004142_abnormal_muscle_tone0.95604911
84MP0010368_abnormal_lymphatic_system0.94305424
85MP0005171_absent_coat_pigmentation0.94214133
86MP0008057_abnormal_DNA_replication0.93300717
87MP0010386_abnormal_urinary_bladder0.93151755
88MP0008789_abnormal_olfactory_epithelium0.92466330
89MP0005623_abnormal_meninges_morphology0.92229090
90MP0003953_abnormal_hormone_level0.88967468
91MP0005448_abnormal_energy_balance0.88776124
92MP0001542_abnormal_bone_strength0.86739794
93MP0001963_abnormal_hearing_physiology0.85047576
94MP0003633_abnormal_nervous_system0.84395454
95MP0000003_abnormal_adipose_tissue0.81620773
96MP0003631_nervous_system_phenotype0.80230468
97MP0003123_paternal_imprinting0.78721405
98MP0002234_abnormal_pharynx_morphology0.77678488
99MP0002160_abnormal_reproductive_system0.74324801
100MP0003137_abnormal_impulse_conducting0.74217293
101MP0002229_neurodegeneration0.73377590
102MP0002896_abnormal_bone_mineralization0.72834633
103MP0003959_abnormal_lean_body0.72783020
104MP0005253_abnormal_eye_physiology0.71561812
105MP0004145_abnormal_muscle_electrophysio0.71168271
106MP0002069_abnormal_eating/drinking_beha0.71086847
107MP0003634_abnormal_glial_cell0.70609664
108MP0002084_abnormal_developmental_patter0.70261758
109MP0005187_abnormal_penis_morphology0.69867755
110MP0010329_abnormal_lipoprotein_level0.69623487
111MP0005452_abnormal_adipose_tissue0.68997222
112MP0003942_abnormal_urinary_system0.68860189
113MP0003938_abnormal_ear_development0.67843896
114MP0005535_abnormal_body_temperature0.67672359
115MP0008872_abnormal_physiological_respon0.67514708
116MP0000751_myopathy0.66640345
117MP0003632_abnormal_nervous_system0.66607012
118MP0008874_decreased_physiological_sensi0.66263008
119MP0002254_reproductive_system_inflammat0.65955308
120MP0000631_abnormal_neuroendocrine_gland0.65458260
121MP0005646_abnormal_pituitary_gland0.64881381
122MP0000026_abnormal_inner_ear0.62369562
123MP0003122_maternal_imprinting0.61513556
124MP0002085_abnormal_embryonic_tissue0.60503199
125MP0001905_abnormal_dopamine_level0.58621840
126MP0001529_abnormal_vocalization0.58034298
127MP0003755_abnormal_palate_morphology0.57700234
128MP0000534_abnormal_ureter_morphology0.57390265
129MP0005551_abnormal_eye_electrophysiolog0.57155812
130MP0001943_abnormal_respiration0.56839223
131MP0010769_abnormal_survival0.56742481
132MP0004742_abnormal_vestibular_system0.56301942
133MP0010768_mortality/aging0.56016227
134MP0008995_early_reproductive_senescence0.55047943

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)7.23124866
2Hyperinsulinemic hypoglycemia (HP:0000825)6.46325149
3Myokymia (HP:0002411)5.68131161
4Hypoglycemic coma (HP:0001325)5.66409268
5Focal motor seizures (HP:0011153)5.45002758
6Symptomatic seizures (HP:0011145)4.63858612
7Abnormality of the lower motor neuron (HP:0002366)4.59183482
8Focal seizures (HP:0007359)4.51206891
9Hyperglycemia (HP:0003074)4.27310228
10Atonic seizures (HP:0010819)4.13963836
11Abnormal pancreas size (HP:0012094)4.10045899
12Visual hallucinations (HP:0002367)3.97061010
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.91481362
14Ketoacidosis (HP:0001993)3.89360788
15Abnormality of the pancreatic islet cells (HP:0006476)3.86779906
16Abnormality of endocrine pancreas physiology (HP:0012093)3.86779906
17Febrile seizures (HP:0002373)3.86148640
18Epileptic encephalopathy (HP:0200134)3.58380445
19Rib fusion (HP:0000902)3.56689121
20Absence seizures (HP:0002121)3.41501650
21Annular pancreas (HP:0001734)3.39551395
22Prominent metopic ridge (HP:0005487)3.37100945
23Metaphyseal dysplasia (HP:0100255)3.25714805
24Popliteal pterygium (HP:0009756)3.13325612
25Enlarged penis (HP:0000040)3.12692264
26Dialeptic seizures (HP:0011146)3.11301644
27Abnormality of the metopic suture (HP:0005556)3.10430152
28Hepatoblastoma (HP:0002884)3.02692848
29Insulin-resistant diabetes mellitus (HP:0000831)2.96147398
30Progressive cerebellar ataxia (HP:0002073)2.92131182
31Amblyopia (HP:0000646)2.87661617
32Generalized tonic-clonic seizures (HP:0002069)2.87229309
33Large for gestational age (HP:0001520)2.85496201
34Action tremor (HP:0002345)2.82711281
35Abnormality of the pulmonary veins (HP:0011718)2.72244485
36Abnormality of the labia minora (HP:0012880)2.64250181
37Termporal pattern (HP:0011008)2.60549164
38Insidious onset (HP:0003587)2.60549164
39Late onset (HP:0003584)2.57256863
40Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.49486857
41Ankle clonus (HP:0011448)2.48536725
42Akinesia (HP:0002304)2.43174157
43Supranuclear gaze palsy (HP:0000605)2.35547891
44Double outlet right ventricle (HP:0001719)2.34868168
45Congenital malformation of the right heart (HP:0011723)2.34868168
46Impaired vibration sensation in the lower limbs (HP:0002166)2.34442206
47Poor suck (HP:0002033)2.33852501
48Agitation (HP:0000713)2.32703370
49Dysautonomia (HP:0002459)2.32560168
50Insulin resistance (HP:0000855)2.31844924
51Type I diabetes mellitus (HP:0100651)2.30684157
52Sex reversal (HP:0012245)2.29244137
53Abnormal sex determination (HP:0012244)2.29244137
54Ketosis (HP:0001946)2.28778745
55Hypercortisolism (HP:0001578)2.28712188
56Urinary bladder sphincter dysfunction (HP:0002839)2.28370758
57Abnormality of calcium-phosphate metabolism (HP:0100530)2.23214712
58Abnormality of the astrocytes (HP:0100707)2.22286729
59Astrocytoma (HP:0009592)2.22286729
60Large earlobe (HP:0009748)2.20157815
61Insomnia (HP:0100785)2.18632096
62Intention tremor (HP:0002080)2.16909803
63Dysdiadochokinesis (HP:0002075)2.16268171
64Hypomagnesemia (HP:0002917)2.13973995
65Ulnar claw (HP:0001178)2.12980657
66Increased circulating renin level (HP:0000848)2.09871820
67Concave nail (HP:0001598)2.03667645
68Torticollis (HP:0000473)2.03630629
69Dysmetria (HP:0001310)2.02758157
70Growth hormone excess (HP:0000845)2.01722591
71Abnormality of the aortic arch (HP:0012303)1.99686738
72Urinary urgency (HP:0000012)1.99525509
73Amyotrophic lateral sclerosis (HP:0007354)1.97896665
74Impaired smooth pursuit (HP:0007772)1.97800823
75Aqueductal stenosis (HP:0002410)1.97576911
76Menstrual irregularities (HP:0000858)1.97421937
77Diastasis recti (HP:0001540)1.97301752
78Absent speech (HP:0001344)1.96548358
79Anosmia (HP:0000458)1.96527874
80Limb dystonia (HP:0002451)1.95978646
81Ankyloglossia (HP:0010296)1.95290944
82Ependymoma (HP:0002888)1.95091482
83Hypoventilation (HP:0002791)1.95055939
84Hyperphosphatemia (HP:0002905)1.94714493
85Poor eye contact (HP:0000817)1.94034425
86Gaze-evoked nystagmus (HP:0000640)1.93766844
87Hemiparesis (HP:0001269)1.92752580
88Muscular hypotonia of the trunk (HP:0008936)1.91925364
89Genetic anticipation (HP:0003743)1.90169514
90Polyphagia (HP:0002591)1.89432730
91Diminished movement (HP:0002374)1.88657637
92Downturned corners of mouth (HP:0002714)1.86640465
93Neurofibrillary tangles (HP:0002185)1.86504609
94Neoplasm of the adrenal cortex (HP:0100641)1.86025952
95Macroorchidism (HP:0000053)1.84203329
96Epileptiform EEG discharges (HP:0011182)1.84067546
97Spinal muscular atrophy (HP:0007269)1.83255867
98Type 2 muscle fiber atrophy (HP:0003554)1.83028416
99Heterochromia iridis (HP:0001100)1.82957955
100Turricephaly (HP:0000262)1.82860345
101Depression (HP:0000716)1.82544054
102Pointed chin (HP:0000307)1.81979767
103Truncal ataxia (HP:0002078)1.81880795
104Pancreatic islet-cell hyperplasia (HP:0004510)1.81573304
105Short humerus (HP:0005792)1.81223630
106Papilledema (HP:0001085)1.80847679
107Abnormality of magnesium homeostasis (HP:0004921)1.80324726
108Hyperthyroidism (HP:0000836)1.80091712
109Facial hemangioma (HP:0000329)1.78768272
110Overgrowth (HP:0001548)1.76802675
111Lower limb asymmetry (HP:0100559)1.76204153
112Abnormal social behavior (HP:0012433)1.75708036
113Impaired social interactions (HP:0000735)1.75708036
114Gait imbalance (HP:0002141)1.75164454
115Deep palmar crease (HP:0006191)1.74517051
116Abnormality of ocular smooth pursuit (HP:0000617)1.74085276
117Ventricular fibrillation (HP:0001663)1.73942087
118Postural instability (HP:0002172)1.73776010
119Anxiety (HP:0000739)1.73693946
120Aplasia/hypoplasia of the humerus (HP:0006507)1.73241342
121Rectal fistula (HP:0100590)1.73155931
122Rectovaginal fistula (HP:0000143)1.73155931
123Anomalous pulmonary venous return (HP:0010772)1.72591515
124Neoplasm of the heart (HP:0100544)1.71776719
125Congenital hip dislocation (HP:0001374)1.71229828
126Abnormal eating behavior (HP:0100738)1.70928488
127Obstructive sleep apnea (HP:0002870)1.70601896
128Abnormality of the corticospinal tract (HP:0002492)1.70569882
129Lower limb muscle weakness (HP:0007340)1.70032981
130Sleep apnea (HP:0010535)1.69422434
131Shawl scrotum (HP:0000049)1.69008411
132Failure to thrive in infancy (HP:0001531)1.68469899
133Broad-based gait (HP:0002136)1.68240801
134Relative macrocephaly (HP:0004482)1.67723987
135Specific learning disability (HP:0001328)1.66927425
136Incomplete penetrance (HP:0003829)1.65687961
137Focal dystonia (HP:0004373)1.64817504
138EEG with generalized epileptiform discharges (HP:0011198)1.64111651
139Hypogonadotrophic hypogonadism (HP:0000044)1.63929540
140Horizontal nystagmus (HP:0000666)1.63929076
141Orthostatic hypotension (HP:0001278)1.63705526
142Abnormality of dentin (HP:0010299)1.63515263
143Lower limb amyotrophy (HP:0007210)1.63210724
144Spastic gait (HP:0002064)1.62837935
145Delayed gross motor development (HP:0002194)1.62433807
146Fetal akinesia sequence (HP:0001989)1.61875496
147Choroideremia (HP:0001139)1.61660372
148Hemivertebrae (HP:0002937)1.60409573
149Status epilepticus (HP:0002133)1.59611989
150Excessive salivation (HP:0003781)1.58820755
151Drooling (HP:0002307)1.58820755
152Germ cell neoplasia (HP:0100728)1.58692233
153Hammertoe (HP:0001765)1.56378525
154Neoplasm of the oral cavity (HP:0100649)1.56067184
155Delusions (HP:0000746)1.55339765
156Impaired vibratory sensation (HP:0002495)1.54910268
157Rapidly progressive (HP:0003678)1.54774568
158Testicular neoplasm (HP:0010788)1.54465521
159Glioma (HP:0009733)1.54310273
160Renal duplication (HP:0000075)1.54295838
161Intestinal fistula (HP:0100819)1.54295476
162Muscle fiber atrophy (HP:0100295)1.54172148
163Anophthalmia (HP:0000528)1.53982902
164Oligodactyly (hands) (HP:0001180)1.53916399
165Impaired pain sensation (HP:0007328)1.53781661
166Abnormality of pain sensation (HP:0010832)1.53781661
167Hypercalciuria (HP:0002150)1.53605957
168Hypsarrhythmia (HP:0002521)1.53272529
169Medial flaring of the eyebrow (HP:0010747)1.51681830
170Partial agenesis of the corpus callosum (HP:0001338)1.51182268
171Unilateral renal agenesis (HP:0000122)1.50337804
172Male infertility (HP:0003251)1.50031250
173Vertebral clefting (HP:0008428)1.48544137
174Abnormal drinking behavior (HP:0030082)1.47788572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.65427703
2EPHA43.70127842
3NTRK33.58610969
4FRK3.00546505
5TYRO32.77323133
6MUSK2.60133772
7KSR22.59198074
8LATS22.53390957
9PAK62.42637399
10NTRK12.41175679
11PASK2.39072669
12FGFR22.35355651
13DAPK12.26986270
14GRK52.19275021
15MINK12.15640111
16ICK2.10043649
17MAP3K42.09300597
18NTRK22.01407313
19DAPK21.97169533
20TNIK1.96527253
21DDR21.96277359
22PRKD31.83047306
23UHMK11.73430606
24KSR11.70389839
25MARK11.65157994
26MAP3K61.59261186
27RIPK41.58020605
28ARAF1.45480043
29PINK11.42891514
30PLK21.38609769
31CDK121.38247288
32STK381.33465063
33MAP2K71.26989391
34WNK31.23960296
35PNCK1.23183510
36SGK2231.17526465
37SGK4941.17526465
38CDK51.17443590
39MAP2K41.17295714
40STK161.17094156
41CDC42BPA1.15661461
42AKT31.14348802
43EPHA31.12971017
44MAPK151.12549782
45MAP3K21.11904192
46PDGFRA1.11856577
47CAMK1G1.06239426
48RAF10.99967631
49ALK0.99464005
50MATK0.99372031
51FGR0.98198527
52NEK10.97968570
53SIK20.97418439
54ROCK20.96639933
55SGK20.91617410
56TAOK10.91215115
57EPHA20.89368986
58CDK180.85149834
59PRKCG0.84760449
60CDK150.83915983
61CAMKK10.83040001
62CDK140.82767672
63BCR0.82619485
64SCYL20.82278565
65LIMK10.80790888
66CSNK1G10.80503812
67BMX0.80222515
68RET0.79985212
69PRPF4B0.79187157
70PHKG10.78397948
71PHKG20.78397948
72EPHB20.77782213
73MAP3K120.76874101
74MARK20.76766007
75CSNK1G30.76096457
76CAMK2B0.75217274
77CDK11A0.74923421
78CASK0.74499513
79BMPR1B0.73804555
80CAMK2A0.72426216
81PAK30.72270733
82INSRR0.71481155
83FER0.71168625
84LMTK20.70287305
85PRKCE0.66358198
86PRKCH0.64433509
87PRKD20.60844547
88MAP3K130.58726026
89ROCK10.57906085
90CDK30.57805548
91FGFR30.55821714
92STK110.54983107
93MAP3K110.54562574
94MAPK100.53909544
95CSNK1G20.51453998
96BRAF0.51204778
97MAPKAPK30.50593514
98SGK10.50557493
99PTK20.50284851
100CDK190.50277099
101CHEK20.50222169
102DYRK1A0.49805813
103PRKAA10.49008256
104WNK40.48025234
105PTK2B0.47624917
106CSNK1E0.47031451
107SGK30.46945299
108MAPK130.46924185
109PRKCI0.45205001
110CSNK1D0.43638916
111STK390.43586642
112PRKCZ0.42804572
113WNK10.41416058
114MAP2K10.40972971
115CAMK10.40665706
116RPS6KA30.40181067
117RPS6KA20.39326857
118PRKACA0.39293367
119ADRBK20.39148982
120DAPK30.39086190
121CDK70.37061690
122CSNK1A10.36689305
123BRSK10.36373376
124STK38L0.35811072
125DYRK1B0.35800564
126CSNK1A1L0.35106633
127EPHB10.35038455
128CAMK2G0.34976401
129PKN10.34682820
130MAP3K10.33873062
131BRD40.33670835
132MKNK20.33557268
133CAMK2D0.33528032
134DYRK20.31757439
135STK30.31391716
136PLK30.30901214
137CAMK40.30844769
138GSK3B0.30740120
139MOS0.29010682
140HIPK20.28707552
141YES10.27361873
142DMPK0.26899047

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.66623538
2Nicotine addiction_Homo sapiens_hsa050333.31550377
3Synaptic vesicle cycle_Homo sapiens_hsa047213.12035493
4Olfactory transduction_Homo sapiens_hsa047402.77607149
5Long-term potentiation_Homo sapiens_hsa047202.50245660
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.49467672
7Glutamatergic synapse_Homo sapiens_hsa047242.30713706
8Circadian entrainment_Homo sapiens_hsa047132.30117069
9Amphetamine addiction_Homo sapiens_hsa050312.27873103
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23348142
11GABAergic synapse_Homo sapiens_hsa047272.23123910
12Morphine addiction_Homo sapiens_hsa050322.05346526
13Dopaminergic synapse_Homo sapiens_hsa047281.96965222
14Salivary secretion_Homo sapiens_hsa049701.92890804
15Ovarian steroidogenesis_Homo sapiens_hsa049131.86100503
16Vitamin B6 metabolism_Homo sapiens_hsa007501.85331352
17Butanoate metabolism_Homo sapiens_hsa006501.84557767
18Taste transduction_Homo sapiens_hsa047421.73925573
19Insulin secretion_Homo sapiens_hsa049111.73443424
20Steroid biosynthesis_Homo sapiens_hsa001001.68262202
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58399511
22Gastric acid secretion_Homo sapiens_hsa049711.54585826
23Cholinergic synapse_Homo sapiens_hsa047251.54475796
24GnRH signaling pathway_Homo sapiens_hsa049121.54343886
25Oocyte meiosis_Homo sapiens_hsa041141.53537116
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52457012
27Oxytocin signaling pathway_Homo sapiens_hsa049211.52104957
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51393238
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50227455
30Long-term depression_Homo sapiens_hsa047301.48209135
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44136052
32Gap junction_Homo sapiens_hsa045401.43442568
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41858910
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40595867
35Glioma_Homo sapiens_hsa052141.37137348
36Serotonergic synapse_Homo sapiens_hsa047261.35829924
37Calcium signaling pathway_Homo sapiens_hsa040201.34438216
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32221875
39Dorso-ventral axis formation_Homo sapiens_hsa043201.29883736
40Estrogen signaling pathway_Homo sapiens_hsa049151.29740075
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28300785
42ErbB signaling pathway_Homo sapiens_hsa040121.27415836
43Melanogenesis_Homo sapiens_hsa049161.23924504
44Renin secretion_Homo sapiens_hsa049241.23535921
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23030876
46Cocaine addiction_Homo sapiens_hsa050301.22493171
47mTOR signaling pathway_Homo sapiens_hsa041501.19858991
48Axon guidance_Homo sapiens_hsa043601.13778755
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11785512
50VEGF signaling pathway_Homo sapiens_hsa043701.11275024
51cAMP signaling pathway_Homo sapiens_hsa040241.11024985
52Collecting duct acid secretion_Homo sapiens_hsa049661.09999274
53Fatty acid elongation_Homo sapiens_hsa000621.06563613
54Regulation of autophagy_Homo sapiens_hsa041401.04193713
55Protein export_Homo sapiens_hsa030601.02879715
56Phototransduction_Homo sapiens_hsa047441.00068206
57Choline metabolism in cancer_Homo sapiens_hsa052310.99365274
58Hedgehog signaling pathway_Homo sapiens_hsa043400.99017272
59Hippo signaling pathway_Homo sapiens_hsa043900.98412428
60Wnt signaling pathway_Homo sapiens_hsa043100.94398310
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90246394
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88490582
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88328399
64Fatty acid biosynthesis_Homo sapiens_hsa000610.88097745
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87975487
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85902777
67Circadian rhythm_Homo sapiens_hsa047100.84627563
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.83772360
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79496536
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.79235916
71Type II diabetes mellitus_Homo sapiens_hsa049300.78847264
72Cardiac muscle contraction_Homo sapiens_hsa042600.78023300
73Bile secretion_Homo sapiens_hsa049760.77764796
74MAPK signaling pathway_Homo sapiens_hsa040100.77425627
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75141292
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74562589
77Rap1 signaling pathway_Homo sapiens_hsa040150.73800264
78Vibrio cholerae infection_Homo sapiens_hsa051100.73725969
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73492303
80Fatty acid metabolism_Homo sapiens_hsa012120.71244601
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.70897608
82Bladder cancer_Homo sapiens_hsa052190.70175913
83Thyroid hormone synthesis_Homo sapiens_hsa049180.69931181
84beta-Alanine metabolism_Homo sapiens_hsa004100.69731931
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67263608
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66748185
87Tight junction_Homo sapiens_hsa045300.66566613
88Endometrial cancer_Homo sapiens_hsa052130.66285948
89Ras signaling pathway_Homo sapiens_hsa040140.65472855
90Protein digestion and absorption_Homo sapiens_hsa049740.62561372
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62351688
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62243024
93AMPK signaling pathway_Homo sapiens_hsa041520.62207764
94mRNA surveillance pathway_Homo sapiens_hsa030150.61802344
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60998155
96Colorectal cancer_Homo sapiens_hsa052100.59115498
97Alcoholism_Homo sapiens_hsa050340.58838167
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58417906
99Adherens junction_Homo sapiens_hsa045200.58339085
100Thyroid cancer_Homo sapiens_hsa052160.57941609
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57759784
102Inositol phosphate metabolism_Homo sapiens_hsa005620.57147381
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56265196
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55893715
105Glucagon signaling pathway_Homo sapiens_hsa049220.55780792
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55639583
107Insulin signaling pathway_Homo sapiens_hsa049100.54572155
108Non-small cell lung cancer_Homo sapiens_hsa052230.54479150
109Pancreatic secretion_Homo sapiens_hsa049720.54103993
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.53820556
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52901250
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51701624
113Dilated cardiomyopathy_Homo sapiens_hsa054140.51617085
114Prolactin signaling pathway_Homo sapiens_hsa049170.51530827
115Basal cell carcinoma_Homo sapiens_hsa052170.51073080
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.50835290
117Endocytosis_Homo sapiens_hsa041440.50720112
118Notch signaling pathway_Homo sapiens_hsa043300.50234050
119Melanoma_Homo sapiens_hsa052180.50083859
120Folate biosynthesis_Homo sapiens_hsa007900.46747514
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45474577
122Lysine degradation_Homo sapiens_hsa003100.45406805
123Prion diseases_Homo sapiens_hsa050200.44105310
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42847057
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42740951
126Propanoate metabolism_Homo sapiens_hsa006400.41858672
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41521615
128TGF-beta signaling pathway_Homo sapiens_hsa043500.41360875
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41199031
130Renal cell carcinoma_Homo sapiens_hsa052110.40343588
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37177692
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.33966062
133Tryptophan metabolism_Homo sapiens_hsa003800.33455222
134Fat digestion and absorption_Homo sapiens_hsa049750.31177097
135Mineral absorption_Homo sapiens_hsa049780.31054031

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