ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	C4-dicarboxylate transport (GO:0015740)	4.87400061
2	layer formation in cerebral cortex (GO:0021819)	4.87003007
3	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	4.52076684
4	axonal fasciculation (GO:0007413)	4.48061733
5	neuron recognition (GO:0008038)	4.31369732
6	neuron cell-cell adhesion (GO:0007158)	4.11042401
7	mating behavior (GO:0007617)	4.09832060
8	gamma-aminobutyric acid transport (GO:0015812)	4.03716424
9	axonemal dynein complex assembly (GO:0070286)	3.99642654
10	negative regulation of immunoglobulin mediated immune response (GO:0002890)	3.96679920
11	negative regulation of B cell mediated immunity (GO:0002713)	3.96679920
12	cerebellar granule cell differentiation (GO:0021707)	3.92109288
13	dendritic spine morphogenesis (GO:0060997)	3.76151292
14	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.65903657
15	response to histamine (GO:0034776)	3.65191443
16	regulation of synaptic vesicle exocytosis (GO:2000300)	3.63602194
17	presynaptic membrane organization (GO:0097090)	3.56066884
18	synaptic vesicle maturation (GO:0016188)	3.54927550
19	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.51901745
20	presynaptic membrane assembly (GO:0097105)	3.49124084
21	regulation of glutamate receptor signaling pathway (GO:1900449)	3.48265267
22	synaptic vesicle exocytosis (GO:0016079)	3.41069569
23	nucleobase catabolic process (GO:0046113)	3.38556503
24	glutamate secretion (GO:0014047)	3.36918038
25	regulation of synaptic vesicle transport (GO:1902803)	3.33799416
26	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.32271465
27	atrial cardiac muscle cell action potential (GO:0086014)	3.32165503
28	neurotransmitter secretion (GO:0007269)	3.30937039
29	regulation of dendritic spine morphogenesis (GO:0061001)	3.29275468
30	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.26107208
31	vocalization behavior (GO:0071625)	3.25402403
32	locomotory exploration behavior (GO:0035641)	3.22520134
33	suckling behavior (GO:0001967)	3.17226921
34	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.14756961
35	postsynaptic membrane organization (GO:0001941)	3.06431265
36	L-fucose catabolic process (GO:0042355)	3.05507473
37	fucose catabolic process (GO:0019317)	3.05507473
38	L-fucose metabolic process (GO:0042354)	3.05507473
39	neurotransmitter transport (GO:0006836)	3.04344062
40	response to auditory stimulus (GO:0010996)	3.03574437
41	regulation of axon guidance (GO:1902667)	2.99361001
42	opioid receptor signaling pathway (GO:0038003)	2.98234130
43	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.97538086
44	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.97186779
45	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.96214554
46	glutamate receptor signaling pathway (GO:0007215)	2.94447095
47	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.94031396
48	neurotransmitter-gated ion channel clustering (GO:0072578)	2.93136961
49	regulation of glomerular filtration (GO:0003093)	2.92948327
50	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.90145270
51	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.89689837
52	axon ensheathment in central nervous system (GO:0032291)	2.88449183
53	central nervous system myelination (GO:0022010)	2.88449183
54	protein localization to synapse (GO:0035418)	2.88402222
55	regulation of neurotransmitter uptake (GO:0051580)	2.87049596
56	ventricular system development (GO:0021591)	2.86810706
57	substrate-independent telencephalic tangential migration (GO:0021826)	2.85795785
58	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.85795785
59	regulation of membrane repolarization (GO:0060306)	2.84660482
60	dendrite morphogenesis (GO:0048813)	2.83160044
61	sodium ion homeostasis (GO:0055078)	2.78899529
62	cerebellar Purkinje cell layer development (GO:0021680)	2.77878773
63	sodium ion export (GO:0071436)	2.76519368
64	ether lipid metabolic process (GO:0046485)	2.74627217
65	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.74465681
66	synaptic transmission, glutamatergic (GO:0035249)	2.74070586
67	regulation of neuronal synaptic plasticity (GO:0048168)	2.70247617
68	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)	2.70053465
69	oligodendrocyte differentiation (GO:0048709)	2.69292714
70	pyrimidine nucleobase catabolic process (GO:0006208)	2.67241998
71	activation of protein kinase A activity (GO:0034199)	2.66742360
72	positive regulation of protein homooligomerization (GO:0032464)	2.66210045
73	negative regulation of type 2 immune response (GO:0002829)	2.64964109
74	positive regulation of synapse assembly (GO:0051965)	2.63377751
75	regulation of dendritic spine development (GO:0060998)	2.62928157
76	regulation of neurotransmitter levels (GO:0001505)	2.61693252
77	neurotransmitter catabolic process (GO:0042135)	2.59573388
78	ATP hydrolysis coupled proton transport (GO:0015991)	2.59331478
79	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.59331478
80	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.58324016
81	cellular sodium ion homeostasis (GO:0006883)	2.56468916
82	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.56172145
83	neuronal action potential propagation (GO:0019227)	2.55557332
84	cellular ketone body metabolic process (GO:0046950)	2.53377171
85	regulation of amino acid transport (GO:0051955)	2.51363981
86	cholesterol catabolic process (GO:0006707)	2.50616719
87	sterol catabolic process (GO:0016127)	2.50616719
88	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	2.50027429
89	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.49840736
90	synaptic vesicle endocytosis (GO:0048488)	2.49277163
91	regulation of amyloid precursor protein catabolic process (GO:1902991)	2.49175912
92	response to methylmercury (GO:0051597)	2.48702399
93	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.48566066
94	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.44087903
95	ATP synthesis coupled proton transport (GO:0015986)	2.44087903
96	auditory behavior (GO:0031223)	2.43674009
97	negative regulation of neurotransmitter transport (GO:0051589)	2.42959107
98	regulation of potassium ion transmembrane transport (GO:1901379)	2.42939104
99	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	2.42628047
100	organelle transport along microtubule (GO:0072384)	2.42451444

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.70018425
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.97392962
3	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.92534808
4	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.82889747
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.66330342
6	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.53705134
7	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.50653518
8	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.44621231
9	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.41609913
10	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.36405440
11	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.36405440
12	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.35643251
13	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.29514763
14	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.20529742
15	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.15949299
16	ZNF274_21170338_ChIP-Seq_K562_Hela	1.94951871
17	AR_21572438_ChIP-Seq_LNCaP_Human	1.93376802
18	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.92917555
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.90079040
20	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.88821864
21	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.87165535
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.86923992
23	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.86800521
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.83466600
25	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.81412667
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.81284704
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77534830
28	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.74788487
29	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.72302992
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70789998
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.68510321
32	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.67341128
33	DROSHA_22980978_ChIP-Seq_HELA_Human	1.66964817
34	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.66687355
35	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.59548345
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55922320
37	P300_19829295_ChIP-Seq_ESCs_Human	1.54778028
38	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.53649004
39	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.53075353
40	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.49037040
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42002793
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41832684
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.39867251
44	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.38530279
45	* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37450923
46	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.36243853
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33182055
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32719518
49	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.32432593
50	HTT_18923047_ChIP-ChIP_STHdh_Human	1.30679941
51	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.28746230
52	TP53_18474530_ChIP-ChIP_U2OS_Human	1.27129705
53	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.25856203
54	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.25740569
55	* AR_25329375_ChIP-Seq_VCAP_Human	1.25046290
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.24076941
57	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23819375
58	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.22925526
59	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.22097162
60	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.19842026
61	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18939875
62	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.18587162
63	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.16792675
64	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.13166493
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11879521
66	IGF1R_20145208_ChIP-Seq_DFB_Human	1.11521687
67	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.11472340
68	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.11245167
69	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.09240999
70	* SMAD3_21741376_ChIP-Seq_HESCs_Human	1.09023341
71	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.06519629
72	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.05837770
73	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.02282567
74	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.02281091
75	BCAT_22108803_ChIP-Seq_LS180_Human	0.99937505
76	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98143559
77	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.97912721
78	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.96277073
79	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.96089380
80	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.95634397
81	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.95634397
82	* SMAD4_21741376_ChIP-Seq_HESCs_Human	0.95363581
83	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.94965143
84	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.94713909
85	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.94099508
86	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.93796377
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92738051
88	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91373161
89	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.91096670
90	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.89313835
91	RNF2_27304074_Chip-Seq_NSC_Mouse	0.89298999
92	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.88369366
93	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.87956160
94	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.87837056
95	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.87079762
96	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.86950220
97	AR_19668381_ChIP-Seq_PC3_Human	0.86916350
98	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.85928735
99	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.85367813
100	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.85304522

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	6.50508977
2	MP0005423_abnormal_somatic_nervous	5.03777623
3	MP0004858_abnormal_nervous_system	3.53877225
4	MP0004859_abnormal_synaptic_plasticity	3.35111844
5	MP0003635_abnormal_synaptic_transmissio	2.87052286
6	MP0003329_amyloid_beta_deposits	2.79414330
7	MP0002064_seizures	2.64971172
8	MP0004270_analgesia	2.55204326
9	MP0003690_abnormal_glial_cell	2.54420999
10	MP0002837_dystrophic_cardiac_calcinosis	2.52756691
11	MP0009745_abnormal_behavioral_response	2.41079834
12	MP0005167_abnormal_blood-brain_barrier	2.34249949
13	MP0003122_maternal_imprinting	2.30095007
14	MP0001440_abnormal_grooming_behavior	2.11807577
15	MP0001501_abnormal_sleep_pattern	2.07070935
16	MP0009046_muscle_twitch	2.06170802
17	MP0000604_amyloidosis	2.04570043
18	MP0004885_abnormal_endolymph	2.03128602
19	MP0002063_abnormal_learning/memory/cond	1.97945997
20	MP0002822_catalepsy	1.88780229
21	MP0010234_abnormal_vibrissa_follicle	1.88565050
22	MP0004145_abnormal_muscle_electrophysio	1.88059771
23	MP0000013_abnormal_adipose_tissue	1.86482648
24	MP0002254_reproductive_system_inflammat	1.86285157
25	MP0001968_abnormal_touch/_nociception	1.84666962
26	MP0002572_abnormal_emotion/affect_behav	1.79867911
27	MP0001486_abnormal_startle_reflex	1.79540782
28	MP0002272_abnormal_nervous_system	1.63880770
29	MP0005379_endocrine/exocrine_gland_phen	1.56751044
30	MP0005187_abnormal_penis_morphology	1.56620116
31	MP0000920_abnormal_myelination	1.54845795
32	MP0004043_abnormal_pH_regulation	1.53053449
33	MP0008875_abnormal_xenobiotic_pharmacok	1.52627325
34	MP0002736_abnormal_nociception_after	1.46713577
35	MP0005360_urolithiasis	1.45102279
36	MP0005171_absent_coat_pigmentation	1.43478732
37	MP0003634_abnormal_glial_cell	1.42806049
38	MP0002734_abnormal_mechanical_nocicepti	1.38881685
39	MP0002295_abnormal_pulmonary_circulatio	1.36860651
40	MP0005647_abnormal_sex_gland	1.36611386
41	MP0003787_abnormal_imprinting	1.36124200
42	MP0002139_abnormal_hepatobiliary_system	1.35214553
43	MP0000778_abnormal_nervous_system	1.33938646
44	MP0002733_abnormal_thermal_nociception	1.33539088
45	MP0005085_abnormal_gallbladder_physiolo	1.30393067
46	MP0002909_abnormal_adrenal_gland	1.29523712
47	MP0003633_abnormal_nervous_system	1.24494423
48	MP0006276_abnormal_autonomic_nervous	1.19718351
49	MP0004036_abnormal_muscle_relaxation	1.17777831
50	MP0008260_abnormal_autophagy	1.16204695
51	MP0002067_abnormal_sensory_capabilities	1.14817235
52	MP0004924_abnormal_behavior	1.13392516
53	MP0005386_behavior/neurological_phenoty	1.13392516
54	MP0003631_nervous_system_phenotype	1.13087918
55	MP0001970_abnormal_pain_threshold	1.12342908
56	MP0002184_abnormal_innervation	1.11598158
57	MP0008995_early_reproductive_senescence	1.10216269
58	MP0002089_abnormal_postnatal_growth/wei	1.09432430
59	MP0003121_genomic_imprinting	1.08897950
60	MP0001502_abnormal_circadian_rhythm	1.08524239
61	MP0003632_abnormal_nervous_system	1.05388552
62	MP0002557_abnormal_social/conspecific_i	1.04705084
63	MP0002066_abnormal_motor_capabilities/c	1.02460494
64	MP0004142_abnormal_muscle_tone	1.01502239
65	MP0004742_abnormal_vestibular_system	1.00885990
66	MP0005584_abnormal_enzyme/coenzyme_acti	0.97904882
67	MP0000955_abnormal_spinal_cord	0.95275438
68	MP0003300_gastrointestinal_ulcer	0.95196566
69	MP0001177_atelectasis	0.93632837
70	MP0002735_abnormal_chemical_nociception	0.93386044
71	MP0003137_abnormal_impulse_conducting	0.93126319
72	MP0010386_abnormal_urinary_bladder	0.92020422
73	MP0003879_abnormal_hair_cell	0.91351513
74	MP0006054_spinal_hemorrhage	0.90601170
75	MP0002882_abnormal_neuron_morphology	0.90177596
76	MP0005646_abnormal_pituitary_gland	0.85500412
77	MP0005636_abnormal_mineral_homeostasis	0.85183576
78	MP0001664_abnormal_digestion	0.82390473
79	MP0003959_abnormal_lean_body	0.81614306
80	MP0005332_abnormal_amino_acid	0.78341376
81	MP0004811_abnormal_neuron_physiology	0.78044542
82	MP0002229_neurodegeneration	0.76615244
83	MP0010329_abnormal_lipoprotein_level	0.76515289
84	MP0005535_abnormal_body_temperature	0.75195893
85	MP0009780_abnormal_chondrocyte_physiolo	0.74268346
86	MP0001485_abnormal_pinna_reflex	0.71432748
87	MP0005551_abnormal_eye_electrophysiolog	0.70966486
88	MP0001765_abnormal_ion_homeostasis	0.70267568
89	MP0001943_abnormal_respiration	0.67452016
90	MP0005623_abnormal_meninges_morphology	0.66886737
91	MP0004085_abnormal_heartbeat	0.66756728
92	MP0003718_maternal_effect	0.66496844
93	MP0002152_abnormal_brain_morphology	0.65597085
94	MP0000751_myopathy	0.65224911
95	MP0002971_abnormal_brown_adipose	0.63902865
96	MP0004130_abnormal_muscle_cell	0.63353599
97	MP0003075_altered_response_to	0.63133661
98	MP0008569_lethality_at_weaning	0.60404237
99	MP0000747_muscle_weakness	0.58834616
100	MP0002972_abnormal_cardiac_muscle	0.57181427

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.63899780
2	Neurofibrillary tangles (HP:0002185)	4.97173752
3	Supranuclear gaze palsy (HP:0000605)	4.85968535
4	Cerebral inclusion bodies (HP:0100314)	4.25161803
5	Polyphagia (HP:0002591)	4.00181923
6	Scanning speech (HP:0002168)	3.55554277
7	Epileptic encephalopathy (HP:0200134)	3.55247174
8	Diplopia (HP:0000651)	3.52190980
9	Abnormality of binocular vision (HP:0011514)	3.52190980
10	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.45885760
11	Chronic bronchitis (HP:0004469)	3.41298070
12	Spinal cord compression (HP:0002176)	3.38957026
13	Absent/shortened dynein arms (HP:0200106)	3.28830849
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.28830849
15	Abnormal respiratory motile cilium physiology (HP:0012261)	3.27267697
16	Delayed CNS myelination (HP:0002188)	3.18449859
17	Status epilepticus (HP:0002133)	3.14114446
18	Agitation (HP:0000713)	3.07288089
19	Myokymia (HP:0002411)	2.96957319
20	Abnormal eating behavior (HP:0100738)	2.92285920
21	Anxiety (HP:0000739)	2.84052629
22	Sensorimotor neuropathy (HP:0007141)	2.83160123
23	Dysmetria (HP:0001310)	2.82069994
24	Focal seizures (HP:0007359)	2.81595039
25	Atonic seizures (HP:0010819)	2.76188579
26	Rhinitis (HP:0012384)	2.70760433
27	Focal motor seizures (HP:0011153)	2.63783634
28	Hemiparesis (HP:0001269)	2.63106586
29	Hyperglycinemia (HP:0002154)	2.61312658
30	Progressive cerebellar ataxia (HP:0002073)	2.60122347
31	Abnormal pupillary function (HP:0007686)	2.60119870
32	Truncal ataxia (HP:0002078)	2.57153700
33	Postural instability (HP:0002172)	2.54629557
34	Dysdiadochokinesis (HP:0002075)	2.53234577
35	Febrile seizures (HP:0002373)	2.48541307
36	Psychosis (HP:0000709)	2.45410669
37	Skin nodule (HP:0200036)	2.43789199
38	Excessive salivation (HP:0003781)	2.42405153
39	Drooling (HP:0002307)	2.42405153
40	Nasal speech (HP:0001611)	2.38597888
41	Xanthomatosis (HP:0000991)	2.36850044
42	Hyperlipoproteinemia (HP:0010980)	2.36507623
43	Generalized tonic-clonic seizures (HP:0002069)	2.34894384
44	Intrahepatic cholestasis (HP:0001406)	2.29636933
45	Tachypnea (HP:0002789)	2.28169707
46	Broad metatarsal (HP:0001783)	2.27200468
47	Narrow nasal bridge (HP:0000446)	2.25305273
48	Parakeratosis (HP:0001036)	2.23138952
49	Diastasis recti (HP:0001540)	2.20377738
50	Restlessness (HP:0000711)	2.20275100
51	Spastic paraparesis (HP:0002313)	2.19128874
52	Absence seizures (HP:0002121)	2.17101606
53	Aplasia involving bones of the extremities (HP:0009825)	2.16856145
54	Aplasia involving bones of the upper limbs (HP:0009823)	2.16856145
55	Aplasia of the phalanges of the hand (HP:0009802)	2.16856145
56	Hypophosphatemic rickets (HP:0004912)	2.14418219
57	Spastic gait (HP:0002064)	2.10948159
58	Difficulty running (HP:0009046)	2.10574588
59	Facial shape deformation (HP:0011334)	2.10170055
60	Potter facies (HP:0002009)	2.10170055
61	Amyloidosis (HP:0011034)	2.08753872
62	Urinary urgency (HP:0000012)	2.07608732
63	Prolonged QT interval (HP:0001657)	2.06832363
64	Paraparesis (HP:0002385)	2.04718715
65	Diaphragmatic weakness (HP:0009113)	2.01435618
66	Osteomalacia (HP:0002749)	2.00707028
67	Pheochromocytoma (HP:0002666)	2.00241403
68	Global brain atrophy (HP:0002283)	1.99810869
69	Deep venous thrombosis (HP:0002625)	1.99136751
70	Dialeptic seizures (HP:0011146)	1.98736521
71	Autoimmune thrombocytopenia (HP:0001973)	1.98293295
72	Tubulointerstitial fibrosis (HP:0005576)	1.93811538
73	Cerebral hemorrhage (HP:0001342)	1.93472166
74	Milia (HP:0001056)	1.90683535
75	Ketosis (HP:0001946)	1.88354266
76	Broad-based gait (HP:0002136)	1.87933832
77	Abnormality of the labia minora (HP:0012880)	1.82795224
78	Chronic otitis media (HP:0000389)	1.82019655
79	Confusion (HP:0001289)	1.79040124
80	Abnormal gallbladder physiology (HP:0012438)	1.78373248
81	Cholecystitis (HP:0001082)	1.78373248
82	Retinal dysplasia (HP:0007973)	1.73377213
83	Neuronal loss in central nervous system (HP:0002529)	1.71126939
84	Bradykinesia (HP:0002067)	1.70581294
85	Papilledema (HP:0001085)	1.70210802
86	Increased connective tissue (HP:0009025)	1.70152338
87	Split foot (HP:0001839)	1.68491047
88	Neuroendocrine neoplasm (HP:0100634)	1.67573779
89	Hemiplegia (HP:0002301)	1.65741443
90	Abnormality of vision evoked potentials (HP:0000649)	1.65665027
91	Hyperventilation (HP:0002883)	1.65554917
92	Abnormality of macular pigmentation (HP:0008002)	1.64014744
93	Rimmed vacuoles (HP:0003805)	1.63792835
94	Amblyopia (HP:0000646)	1.63787655
95	Prolonged partial thromboplastin time (HP:0003645)	1.63714336
96	Hypoalphalipoproteinemia (HP:0003233)	1.62893754
97	Microretrognathia (HP:0000308)	1.61125288
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.60943243
99	Abnormal respiratory epithelium morphology (HP:0012253)	1.60943243
100	Abnormality of salivation (HP:0100755)	1.60505878

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME1	4.42281834
2	PAK3	3.95122672
3	MARK1	3.50632399
4	PNCK	2.93553717
5	ACVR1B	2.73721067
6	UHMK1	2.69087953
7	NTRK2	2.38929416
8	NTRK3	2.31241748
9	CAMKK2	2.25682570
10	MAP3K13	2.24553131
11	PAK6	2.18568831
12	MAP3K4	2.14498058
13	CAMKK1	1.92697299
14	SIK2	1.92244216
15	PRKD3	1.81415390
16	ERBB3	1.69990215
17	EPHA4	1.67315232
18	CASK	1.57039315
19	MAP2K4	1.56886431
20	MAP2K7	1.56679449
21	KSR2	1.56078723
22	MINK1	1.45660821
23	CAMK2B	1.37103245
24	CDK5	1.37040275
25	OXSR1	1.32511300
26	MAP3K14	1.31227144
27	PRPF4B	1.30090592
28	MAPK13	1.28364063
29	BRSK1	1.27069045
30	PRKCH	1.21165856
31	STK39	1.19364387
32	BRSK2	1.18167339
33	LATS2	1.15666728
34	LIMK1	1.13026307
35	CAMK2A	1.10481830
36	MST4	1.10116404
37	CAMK1G	1.07926500
38	NTRK1	1.04800041
39	PHKG1	1.04067518
40	PHKG2	1.04067518
41	FGR	0.95192465
42	BCKDK	0.95184773
43	ROCK2	0.94159491
44	PRKCG	0.93823427
45	STK24	0.93110299
46	ADRBK1	0.88112383
47	SGK1	0.86470432
48	PKN1	0.82345976
49	PRKAA2	0.79789213
50	BMPR1B	0.79722120
51	MAPK12	0.78029646
52	PRKCE	0.76091485
53	CDK19	0.75172534
54	SIK1	0.73938407
55	SGK223	0.72574266
56	SGK494	0.72574266
57	PRKCQ	0.68907831
58	CSNK1G2	0.68233500
59	CAMK2D	0.67982295
60	DAPK2	0.67911750
61	TTN	0.66851814
62	CAMK2G	0.66690728
63	BCR	0.62280212
64	CSNK1E	0.62031588
65	PASK	0.61251332
66	MAP2K1	0.60860351
67	FES	0.59145285
68	RPS6KA3	0.57382779
69	MAP3K9	0.55029155
70	RET	0.54386662
71	WNK3	0.53725598
72	PRKACG	0.53253916
73	LRRK2	0.52582097
74	CAMK1D	0.52336547
75	FYN	0.50936223
76	CDK18	0.50295577
77	CDK15	0.50129117
78	SRC	0.49486971
79	CAMK1	0.49274107
80	FER	0.48619687
81	PRKD1	0.47666896
82	DYRK2	0.46271035
83	PRKACB	0.45701709
84	FGFR2	0.45110243
85	IKBKE	0.45028097
86	KSR1	0.44925824
87	PTK6	0.44667003
88	PRKCA	0.44647667
89	CDK14	0.43168229
90	PRKCB	0.43058496
91	CDK11A	0.38916164
92	CSNK1D	0.38875933
93	PRKACA	0.38681264
94	GRK5	0.37748518
95	CSNK1G3	0.37509580
96	GRK6	0.37393624
97	CSNK1A1L	0.37224539
98	MAPK10	0.36626768
99	PRKG1	0.36413015
100	PRKCZ	0.36058102

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.44950517
2	Collecting duct acid secretion_Homo sapiens_hsa04966	2.71304535
3	GABAergic synapse_Homo sapiens_hsa04727	2.68118749
4	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.64938272
5	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.26942039
6	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.15082938
7	Morphine addiction_Homo sapiens_hsa05032	2.02429448
8	Circadian entrainment_Homo sapiens_hsa04713	1.92837540
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.92498704
10	Glutamatergic synapse_Homo sapiens_hsa04724	1.89254538
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.87844775
12	Arginine biosynthesis_Homo sapiens_hsa00220	1.74881197
13	Fatty acid elongation_Homo sapiens_hsa00062	1.72005506
14	Butanoate metabolism_Homo sapiens_hsa00650	1.66023018
15	Bile secretion_Homo sapiens_hsa04976	1.58805317
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.57059651
17	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.54174742
18	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.53905273
19	Vibrio cholerae infection_Homo sapiens_hsa05110	1.53729789
20	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.53319259
21	Gastric acid secretion_Homo sapiens_hsa04971	1.51095429
22	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.50934719
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.49787550
24	Long-term potentiation_Homo sapiens_hsa04720	1.44619695
25	Long-term depression_Homo sapiens_hsa04730	1.34812688
26	Taste transduction_Homo sapiens_hsa04742	1.34370447
27	Amphetamine addiction_Homo sapiens_hsa05031	1.29084881
28	Salivary secretion_Homo sapiens_hsa04970	1.25781166
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21811117
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.21071255
31	Olfactory transduction_Homo sapiens_hsa04740	1.20370426
32	Fatty acid metabolism_Homo sapiens_hsa01212	1.18989233
33	Cocaine addiction_Homo sapiens_hsa05030	1.18963022
34	Dopaminergic synapse_Homo sapiens_hsa04728	1.16777432
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.14421605
36	Serotonergic synapse_Homo sapiens_hsa04726	1.11282161
37	Prion diseases_Homo sapiens_hsa05020	1.11199981
38	Axon guidance_Homo sapiens_hsa04360	1.07733562
39	Insulin secretion_Homo sapiens_hsa04911	1.06986403
40	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.05197562
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01495042
42	Renin secretion_Homo sapiens_hsa04924	1.00103935
43	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.98645086
44	Fatty acid degradation_Homo sapiens_hsa00071	0.93005711
45	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.91395425
46	PPAR signaling pathway_Homo sapiens_hsa03320	0.91255552
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.90309176
48	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.89912245
49	Complement and coagulation cascades_Homo sapiens_hsa04610	0.88714333
50	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.88201872
51	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.85628315
52	Alzheimers disease_Homo sapiens_hsa05010	0.83107906
53	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.81073133
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80724116
55	GnRH signaling pathway_Homo sapiens_hsa04912	0.79814217
56	Cholinergic synapse_Homo sapiens_hsa04725	0.79478485
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.77502837
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76510614
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76448687
60	Histidine metabolism_Homo sapiens_hsa00340	0.74994811
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74439063
62	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.72683862
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71134644
64	Sulfur metabolism_Homo sapiens_hsa00920	0.69278692
65	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.66326531
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.66039247
67	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.65951189
68	Phagosome_Homo sapiens_hsa04145	0.65940991
69	Gap junction_Homo sapiens_hsa04540	0.65630234
70	Circadian rhythm_Homo sapiens_hsa04710	0.65375688
71	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.65008955
72	Type I diabetes mellitus_Homo sapiens_hsa04940	0.64313299
73	Estrogen signaling pathway_Homo sapiens_hsa04915	0.63837196
74	Rheumatoid arthritis_Homo sapiens_hsa05323	0.62448068
75	Pancreatic secretion_Homo sapiens_hsa04972	0.60824367
76	Melanogenesis_Homo sapiens_hsa04916	0.60252206
77	cAMP signaling pathway_Homo sapiens_hsa04024	0.55847058
78	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55473562
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55289913
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.55217145
81	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.54161216
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.53391924
83	ABC transporters_Homo sapiens_hsa02010	0.53017209
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.52235315
85	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.52161253
86	Parkinsons disease_Homo sapiens_hsa05012	0.51054791
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50278023
88	Type II diabetes mellitus_Homo sapiens_hsa04930	0.46954568
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.45830087
90	ErbB signaling pathway_Homo sapiens_hsa04012	0.45477022
91	Propanoate metabolism_Homo sapiens_hsa00640	0.45157209
92	Ether lipid metabolism_Homo sapiens_hsa00565	0.44871862
93	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.42920695
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.42660348
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.41515526
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39618576
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.38311149
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37970404
99	Peroxisome_Homo sapiens_hsa04146	0.37957820
100	Glucagon signaling pathway_Homo sapiens_hsa04922	0.36882134

NPVF

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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