NPW

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chemical homeostasis within a tissue (GO:0048875)8.67517448
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.88466483
3purine nucleobase biosynthetic process (GO:0009113)5.36934609
4regulation of mitochondrial translation (GO:0070129)5.24245641
5negative regulation of B cell apoptotic process (GO:0002903)5.05005071
6nucleobase biosynthetic process (GO:0046112)5.03909598
7negative regulation of mRNA splicing, via spliceosome (GO:0048025)5.03889438
8response to xenobiotic stimulus (GO:0009410)4.83161924
9maturation of SSU-rRNA (GO:0030490)4.77440467
10deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.72818186
11formation of translation preinitiation complex (GO:0001731)4.71345987
12ribosomal small subunit biogenesis (GO:0042274)4.64565069
13viral transcription (GO:0019083)4.62107123
14translational termination (GO:0006415)4.53919171
15negative regulation of mRNA processing (GO:0050686)4.44223308
16purine deoxyribonucleotide catabolic process (GO:0009155)4.39659806
17pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.39252182
18ribosomal small subunit assembly (GO:0000028)4.29087875
19negative regulation of RNA splicing (GO:0033119)4.29030153
20deoxyribose phosphate biosynthetic process (GO:0046385)4.25434440
212-deoxyribonucleotide biosynthetic process (GO:0009265)4.25434440
22translational initiation (GO:0006413)4.20160948
23ribosomal large subunit biogenesis (GO:0042273)4.16459759
24establishment of integrated proviral latency (GO:0075713)4.13705758
25deoxyribonucleotide catabolic process (GO:0009264)4.13545304
26pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.12723565
27intestinal epithelial cell development (GO:0060576)4.10338716
28ribosome assembly (GO:0042255)4.09194706
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.08679557
30base-excision repair, AP site formation (GO:0006285)4.07747182
31transcription from mitochondrial promoter (GO:0006390)4.07131629
32exocrine pancreas development (GO:0031017)4.06371756
33cotranslational protein targeting to membrane (GO:0006613)4.01681582
34protein targeting to ER (GO:0045047)4.01640816
35translational elongation (GO:0006414)3.99460573
36DNA deamination (GO:0045006)3.97904620
37mitotic metaphase plate congression (GO:0007080)3.92972242
38deoxyribose phosphate catabolic process (GO:0046386)3.86974774
39GMP metabolic process (GO:0046037)3.86844162
40protein localization to endoplasmic reticulum (GO:0070972)3.82995295
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.80064751
42folic acid metabolic process (GO:0046655)3.76819114
43ribonucleoprotein complex biogenesis (GO:0022613)3.76570186
44intestinal cholesterol absorption (GO:0030299)3.75786286
45oxidative phosphorylation (GO:0006119)3.74036907
46protein retention in ER lumen (GO:0006621)3.73000018
47negative regulation of transcription by competitive promoter binding (GO:0010944)3.72798336
48pattern specification involved in kidney development (GO:0061004)3.69560244
49negative regulation of mRNA metabolic process (GO:1903312)3.69531077
50positive regulation of megakaryocyte differentiation (GO:0045654)3.66651821
51DNA replication checkpoint (GO:0000076)3.66022938
522-deoxyribonucleotide metabolic process (GO:0009394)3.63220884
53proline biosynthetic process (GO:0006561)3.61253206
54ubiquinone biosynthetic process (GO:0006744)3.60266047
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55647994
56pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.54892841
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54374052
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.54374052
59NADH dehydrogenase complex assembly (GO:0010257)3.54374052
60DNA unwinding involved in DNA replication (GO:0006268)3.51052912
61pyrimidine nucleotide catabolic process (GO:0006244)3.49089879
62DNA replication initiation (GO:0006270)3.45825594
63digestion (GO:0007586)3.45383376
64protein complex biogenesis (GO:0070271)3.44587135
65viral life cycle (GO:0019058)3.43074458
66ribosome biogenesis (GO:0042254)3.42182241
67cellular protein complex disassembly (GO:0043624)3.42102938
68GTP biosynthetic process (GO:0006183)3.39567156
69mitotic recombination (GO:0006312)3.38521641
70UV protection (GO:0009650)3.37276718
71UTP biosynthetic process (GO:0006228)3.36367544
72deoxyribose phosphate metabolic process (GO:0019692)3.35966795
73translation (GO:0006412)3.35112798
74rRNA processing (GO:0006364)3.34196358
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.33465869
76DNA strand elongation involved in DNA replication (GO:0006271)3.32678051
77regulation of RIG-I signaling pathway (GO:0039535)3.31004996
78mitochondrial respiratory chain complex assembly (GO:0033108)3.29494390
79cellular response to nitric oxide (GO:0071732)3.27548221
80guanosine-containing compound biosynthetic process (GO:1901070)3.26747392
81quinone biosynthetic process (GO:1901663)3.25645146
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.25115131
83telomere maintenance via semi-conservative replication (GO:0032201)3.25013120
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23890568
85base-excision repair (GO:0006284)3.23742687
86rRNA modification (GO:0000154)3.23340084
87DNA damage response, signal transduction resulting in transcription (GO:0042772)3.23037720
88purine deoxyribonucleotide metabolic process (GO:0009151)3.22999956
89cytochrome complex assembly (GO:0017004)3.21242786
90positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.21202391
91mitochondrial RNA metabolic process (GO:0000959)3.21122231
92UTP metabolic process (GO:0046051)3.20697356
93establishment of apical/basal cell polarity (GO:0035089)3.20375950
94negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.20248618
95establishment of viral latency (GO:0019043)3.19694012
96rRNA metabolic process (GO:0016072)3.18103644
97dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.17985371
98viral mRNA export from host cell nucleus (GO:0046784)3.17453465
99pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.16886332
100nucleobase-containing small molecule interconversion (GO:0015949)3.16558101
101DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.16407886
102DNA strand elongation (GO:0022616)3.14228040
103lung-associated mesenchyme development (GO:0060484)3.13904828
104positive regulation of prostaglandin secretion (GO:0032308)3.13748969
105glyoxylate metabolic process (GO:0046487)3.13232084
106termination of RNA polymerase III transcription (GO:0006386)3.12577965
107transcription elongation from RNA polymerase III promoter (GO:0006385)3.12577965
108positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.10917096
109regulation of B cell apoptotic process (GO:0002902)3.09691519
110regulation of translation in response to stress (GO:0043555)3.08987122
111ubiquinone metabolic process (GO:0006743)3.08344823
112deoxyribonucleotide metabolic process (GO:0009262)3.07992440
113negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.07405875
114response to peptidoglycan (GO:0032494)3.05029383
115estrogen biosynthetic process (GO:0006703)3.04163447
116deoxyribonucleotide biosynthetic process (GO:0009263)3.02355653
117regulation of nuclear cell cycle DNA replication (GO:0033262)3.01786587
118negative regulation of cell aging (GO:0090344)3.01575704
119translesion synthesis (GO:0019985)3.00833775
120aerobic respiration (GO:0009060)3.00378754
121pentose metabolic process (GO:0019321)3.00338418
122folic acid-containing compound biosynthetic process (GO:0009396)2.98583940
123L-serine metabolic process (GO:0006563)2.98421716
124mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96833038
125GDP-mannose metabolic process (GO:0019673)2.96583178
126regulation of phospholipid biosynthetic process (GO:0071071)2.95174516
127epithelial cell differentiation involved in prostate gland development (GO:0060742)2.94847948
128regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.93933391
129lung secretory cell differentiation (GO:0061140)2.93490896
130protein complex disassembly (GO:0043241)2.93190776
131nucleotide-excision repair, DNA gap filling (GO:0006297)2.92446987
132serine family amino acid biosynthetic process (GO:0009070)2.90569082
133definitive hemopoiesis (GO:0060216)2.90157618
134amino acid salvage (GO:0043102)2.87552179
135L-methionine salvage (GO:0071267)2.87552179
136L-methionine biosynthetic process (GO:0071265)2.87552179
137regulation of spindle organization (GO:0090224)2.87282671
138metaphase plate congression (GO:0051310)2.86850783
139mature B cell differentiation involved in immune response (GO:0002313)2.83540246
140glycine metabolic process (GO:0006544)2.83226663
141nuclear-transcribed mRNA catabolic process (GO:0000956)2.82837654
142protein localization to kinetochore (GO:0034501)2.81909809
143spliceosomal snRNP assembly (GO:0000387)2.79542572
144grooming behavior (GO:0007625)2.79305190
145macrophage differentiation (GO:0030225)2.79084763
146Peyers patch development (GO:0048541)2.78993894
147mucosal-associated lymphoid tissue development (GO:0048537)2.78993894
148negative regulation of myeloid cell apoptotic process (GO:0033033)2.78526067
149cysteine metabolic process (GO:0006534)2.77351119
150negative regulation of JAK-STAT cascade (GO:0046426)2.76422443
151negative regulation of cell cycle arrest (GO:0071157)2.75361442
152proline metabolic process (GO:0006560)2.74635739
153polyamine biosynthetic process (GO:0006596)2.74417632
154pseudouridine synthesis (GO:0001522)2.73950416
155cellular component biogenesis (GO:0044085)2.73892881
156endothelial tube morphogenesis (GO:0061154)2.73291368
157morphogenesis of an endothelium (GO:0003159)2.73291368
158macromolecular complex disassembly (GO:0032984)2.72478239
159protein maturation by protein folding (GO:0022417)2.72474214
160disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.70974607
161establishment of protein localization to mitochondrial membrane (GO:0090151)2.68011218
162protein targeting to membrane (GO:0006612)2.67991802
163mRNA catabolic process (GO:0006402)2.67477368
164transcription from RNA polymerase I promoter (GO:0006360)2.66988933
165telomere maintenance via recombination (GO:0000722)2.66147234
166RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.63069269
167positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62698704
168negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61959418
169regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.61416451
170anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60535132
171positive regulation of chromosome segregation (GO:0051984)2.60482176
172RNA catabolic process (GO:0006401)2.60440381
173surfactant homeostasis (GO:0043129)10.8678636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.59075778
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.50580378
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.75304511
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59081155
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.39352503
6VDR_21846776_ChIP-Seq_THP-1_Human3.21021731
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08620252
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93477742
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.93460955
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74003459
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.73264360
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69746340
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68752304
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68344404
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.49459448
16AR_21909140_ChIP-Seq_LNCAP_Human2.40151077
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37934505
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18894793
19XRN2_22483619_ChIP-Seq_HELA_Human2.18645911
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.15620086
21SCL_19346495_ChIP-Seq_HPC-7_Human2.03948269
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01377883
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98705766
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96296737
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96296737
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96296737
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.94048655
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93204618
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92600503
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92086190
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79534905
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79150084
33CIITA_25753668_ChIP-Seq_RAJI_Human1.75546856
34ZNF263_19887448_ChIP-Seq_K562_Human1.73441175
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.73194439
36DCP1A_22483619_ChIP-Seq_HELA_Human1.72385477
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70849843
38VDR_24763502_ChIP-Seq_THP-1_Human1.69591578
39LXR_22292898_ChIP-Seq_THP-1_Human1.68191461
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.66649486
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66529339
42VDR_23849224_ChIP-Seq_CD4+_Human1.66321924
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64847136
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64227125
45GABP_19822575_ChIP-Seq_HepG2_Human1.62249770
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.58937670
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56778214
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55218647
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.54267955
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53991492
51TTF2_22483619_ChIP-Seq_HELA_Human1.53551473
52P68_20966046_ChIP-Seq_HELA_Human1.51531525
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50565029
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.49073953
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48151727
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.46655021
57NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.46290503
58BCL6_27268052_Chip-Seq_Bcells_Human1.40185917
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.39920615
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38983463
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37963849
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37818317
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37682670
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36868464
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35748074
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35160671
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34616221
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34574489
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33125472
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32975030
71* FOXP1_21924763_ChIP-Seq_HESCs_Human1.32925819
72FOXP3_21729870_ChIP-Seq_TREG_Human1.31541901
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.31104809
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29820853
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29466936
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28762839
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28464584
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28281472
79UTX_26944678_Chip-Seq_JUKART_Human1.25478742
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25078937
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25050736
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24722829
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23557745
84* CTCF_21964334_Chip-Seq_Bcells_Human1.22646925
85SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21365120
86ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21281537
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.19892855
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19643082
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19548467
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19495342
91PHF8_20622854_ChIP-Seq_HELA_Human1.18670080
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18653281
93SPI1_23547873_ChIP-Seq_NB4_Human1.17921543
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17081614
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16624801
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16356409
97BCOR_27268052_Chip-Seq_Bcells_Human1.15660563
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15497204
99IRF8_22096565_ChIP-ChIP_GC-B_Human1.15399898
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14575351
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14471699
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14250962
103KDM5A_27292631_Chip-Seq_BREAST_Human1.14181099
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13697925
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13380268
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12789304
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12620659
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.11628705
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10999648
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10792516
111MAF_26560356_Chip-Seq_TH2_Human1.10275948
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10143870
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10090371
114GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09907213
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09038315
116MYC_22102868_ChIP-Seq_BL_Human1.08377200
117YY1_22570637_ChIP-Seq_MALME-3M_Human1.08141028
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07919098
119ETS1_21867929_ChIP-Seq_TH2_Mouse1.07470477
120SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06953471
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06922691
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06544697
123E2F1_20622854_ChIP-Seq_HELA_Human1.06470503
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05909973
125STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03665477
126THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03274413
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03103633
128NANOG_21062744_ChIP-ChIP_HESCs_Human1.02521267
129MYC_18940864_ChIP-ChIP_HL60_Human1.02299600
130CHD1_26751641_Chip-Seq_LNCaP_Human0.97643039
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95962424
132ELK1_19687146_ChIP-ChIP_HELA_Human0.95444664
133ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95337199
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94921300
135GATA4_25053715_ChIP-Seq_YYC3_Human0.93776255
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93692441
137NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93222431
138RACK7_27058665_Chip-Seq_MCF-7_Human0.93148434
139EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93074551
140NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90707831
141SRF_21415370_ChIP-Seq_HL-1_Mouse0.87902019
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87778978
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87462479
144TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86363446
145CLOCK_20551151_ChIP-Seq_293T_Human0.85305508
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84987576
147TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84278983
148PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83662954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog7.63281002
2MP0005083_abnormal_biliary_tract5.98795463
3MP0008995_early_reproductive_senescence4.15734325
4MP0003693_abnormal_embryo_hatching3.58386333
5MP0001958_emphysema3.25446188
6MP0001666_abnormal_nutrient_absorption3.21040084
7MP0004957_abnormal_blastocyst_morpholog3.08504215
8MP0008004_abnormal_stomach_pH2.97446236
9MP0005220_abnormal_exocrine_pancreas2.71053866
10MP0003786_premature_aging2.60579125
11MP0004808_abnormal_hematopoietic_stem2.58018571
12MP0003303_peritoneal_inflammation2.55547899
13MP0002822_catalepsy2.36704851
14MP0006036_abnormal_mitochondrial_physio2.36597579
15MP0002234_abnormal_pharynx_morphology2.26694978
16MP0003111_abnormal_nucleus_morphology2.09855236
17MP0010368_abnormal_lymphatic_system1.99867580
18MP0010094_abnormal_chromosome_stability1.98218491
19MP0003724_increased_susceptibility_to1.90562878
20MP0003718_maternal_effect1.90401292
21MP0009697_abnormal_copulation1.89291540
22MP0002132_abnormal_respiratory_system1.82645208
23MP0000015_abnormal_ear_pigmentation1.82575548
24MP0003077_abnormal_cell_cycle1.82343560
25MP0001177_atelectasis1.81578603
26MP0002277_abnormal_respiratory_mucosa1.78334580
27MP0009840_abnormal_foam_cell1.77538291
28MP0005464_abnormal_platelet_physiology1.76225816
29MP0005388_respiratory_system_phenotype1.75406977
30MP0002133_abnormal_respiratory_system1.75406977
31MP0001730_embryonic_growth_arrest1.74706331
32MP0005084_abnormal_gallbladder_morpholo1.70928828
33MP0010234_abnormal_vibrissa_follicle1.66821308
34MP0005408_hypopigmentation1.63953274
35MP0005365_abnormal_bile_salt1.63538782
36MP0005075_abnormal_melanosome_morpholog1.59768595
37MP0005085_abnormal_gallbladder_physiolo1.58989552
38MP0003436_decreased_susceptibility_to1.58431861
39MP0004147_increased_porphyrin_level1.53200607
40MP0005360_urolithiasis1.51666853
41MP0002160_abnormal_reproductive_system1.51321902
42MP0010030_abnormal_orbit_morphology1.47225041
43MP0001881_abnormal_mammary_gland1.43339563
44MP0000490_abnormal_crypts_of1.40028051
45MP0005666_abnormal_adipose_tissue1.39700480
46MP0005076_abnormal_cell_differentiation1.39331607
47MP0003123_paternal_imprinting1.37381087
48MP0002295_abnormal_pulmonary_circulatio1.36763685
49MP0008057_abnormal_DNA_replication1.31451644
50MP0002398_abnormal_bone_marrow1.29584830
51MP0002970_abnormal_white_adipose1.29546470
52MP0003186_abnormal_redox_activity1.29269889
53MP0002722_abnormal_immune_system1.27507455
54MP0001664_abnormal_digestion1.26649258
55MP0001764_abnormal_homeostasis1.25015343
56MP0005025_abnormal_response_to1.23686414
57MP0003656_abnormal_erythrocyte_physiolo1.22894427
58MP0003763_abnormal_thymus_physiology1.22713596
59MP0005330_cardiomyopathy1.21514942
60MP0002971_abnormal_brown_adipose1.20959246
61MP0005375_adipose_tissue_phenotype1.19143264
62MP0003806_abnormal_nucleotide_metabolis1.16971255
63MP0000350_abnormal_cell_proliferation1.16085108
64MP0004264_abnormal_extraembryonic_tissu1.15488300
65MP0002396_abnormal_hematopoietic_system1.15479293
66MP0008873_increased_physiological_sensi1.13947869
67MP0003191_abnormal_cellular_cholesterol1.11567654
68MP0000678_abnormal_parathyroid_gland1.08857951
69MP0010352_gastrointestinal_tract_polyps1.08031000
70MP0000689_abnormal_spleen_morphology1.07760197
71MP0008875_abnormal_xenobiotic_pharmacok1.07283133
72MP0005623_abnormal_meninges_morphology1.06176960
73MP0000750_abnormal_muscle_regeneration1.04545922
74MP0002429_abnormal_blood_cell1.04296509
75MP0003943_abnormal_hepatobiliary_system1.04209987
76MP0000537_abnormal_urethra_morphology1.01666971
77MP0001853_heart_inflammation1.00323724
78MP0008260_abnormal_autophagy1.00244724
79MP0003567_abnormal_fetal_cardiomyocyte1.00235007
80MP0002080_prenatal_lethality0.99627429
81MP0003638_abnormal_response/metabolism_0.99397324
82MP0006035_abnormal_mitochondrial_morpho0.98193483
83MP0005058_abnormal_lysosome_morphology0.98169859
84MP0000703_abnormal_thymus_morphology0.94889810
85MP0002086_abnormal_extraembryonic_tissu0.93817996
86MP0001697_abnormal_embryo_size0.93592188
87MP0008932_abnormal_embryonic_tissue0.90789547
88MP0005380_embryogenesis_phenotype0.90762290
89MP0001672_abnormal_embryogenesis/_devel0.90762290
90MP0000681_abnormal_thyroid_gland0.90705447
91MP0001545_abnormal_hematopoietic_system0.90634406
92MP0005397_hematopoietic_system_phenotyp0.90634406
93MP0005266_abnormal_metabolism0.90473835
94MP0008058_abnormal_DNA_repair0.89607331
95MP0002098_abnormal_vibrissa_morphology0.89438495
96MP0005636_abnormal_mineral_homeostasis0.88920827
97MP0005501_abnormal_skin_physiology0.88723426
98MP0008007_abnormal_cellular_replicative0.88651525
99MP0000716_abnormal_immune_system0.88375042
100MP0005451_abnormal_body_composition0.88123498
101MP0005334_abnormal_fat_pad0.86598262
102MP0004272_abnormal_basement_membrane0.85954106
103MP0009379_abnormal_foot_pigmentation0.84697098
104MP0009384_cardiac_valve_regurgitation0.84350911
105MP0005499_abnormal_olfactory_system0.84110371
106MP0005394_taste/olfaction_phenotype0.84110371
107MP0002420_abnormal_adaptive_immunity0.83458842
108MP0002085_abnormal_embryonic_tissue0.83374001
109MP0003315_abnormal_perineum_morphology0.82853536
110MP0002138_abnormal_hepatobiliary_system0.82613978
111MP0002148_abnormal_hypersensitivity_rea0.82229235
112MP0002419_abnormal_innate_immunity0.81293692
113MP0003984_embryonic_growth_retardation0.81094808
114MP0005167_abnormal_blood-brain_barrier0.80498903
115MP0001879_abnormal_lymphatic_vessel0.80444136
116MP0003119_abnormal_digestive_system0.80130917
117MP0001819_abnormal_immune_cell0.80064758
118MP0001905_abnormal_dopamine_level0.79855778
119MP0002796_impaired_skin_barrier0.79438838
120MP0000566_synostosis0.79326162
121MP0000598_abnormal_liver_morphology0.79205208
122MP0002019_abnormal_tumor_incidence0.78638928
123MP0009278_abnormal_bone_marrow0.78014740
124MP0002088_abnormal_embryonic_growth/wei0.77808686
125MP0008872_abnormal_physiological_respon0.76852001
126MP0001175_abnormal_lung_morphology0.76760376
127MP0000470_abnormal_stomach_morphology0.76695276
128MP0002405_respiratory_system_inflammati0.76405636
129MP0005023_abnormal_wound_healing0.76311384
130MP0003866_abnormal_defecation0.74855240
131MP0000465_gastrointestinal_hemorrhage0.74206882
132MP0005670_abnormal_white_adipose0.73898644
133MP0001849_ear_inflammation0.73669792
134MP0005332_abnormal_amino_acid0.71657152
135MP0005319_abnormal_enzyme/_coenzyme0.71653789
136MP0001851_eye_inflammation0.71595983
137MP0003075_altered_response_to0.71462994
138MP0002118_abnormal_lipid_homeostasis0.70241041
139MP0005165_increased_susceptibility_to0.69808853
140MP0008469_abnormal_protein_level0.69166432
141MP0000313_abnormal_cell_death0.69146064
142MP0008961_abnormal_basal_metabolism0.67992412
143MP0000358_abnormal_cell_content/0.67585167
144MP0002693_abnormal_pancreas_physiology0.67349023
145MP0004197_abnormal_fetal_growth/weight/0.66531478
146MP0003172_abnormal_lysosome_physiology0.65830193
147MP0000003_abnormal_adipose_tissue0.65797790
148MP0002095_abnormal_skin_pigmentation0.64840419
149MP0002084_abnormal_developmental_patter0.64086340
150MP0001145_abnormal_male_reproductive0.63412617
151MP0006292_abnormal_olfactory_placode0.63339860
152MP0001542_abnormal_bone_strength0.62375438
153MP0009333_abnormal_splenocyte_physiolog0.61948513
154MP0003448_altered_tumor_morphology0.60298277
155MP0000627_abnormal_mammary_gland0.58373274
156MP0003705_abnormal_hypodermis_morpholog0.57565517
157MP0004185_abnormal_adipocyte_glucose0.56918524
158MP0003868_abnormal_feces_composition0.56372630
159MP0009643_abnormal_urine_homeostasis0.55963213
160MP0005395_other_phenotype0.55753337
161MP0001873_stomach_inflammation0.53447011
162MP0000462_abnormal_digestive_system0.52982403
163MP0003115_abnormal_respiratory_system0.52266145
164MP0010678_abnormal_skin_adnexa0.51804217

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)6.79239770
2Hepatocellular necrosis (HP:0001404)5.35343536
3Hepatic necrosis (HP:0002605)4.78551054
4Tubulointerstitial fibrosis (HP:0005576)4.76202111
5Tachypnea (HP:0002789)4.59224444
6Renal salt wasting (HP:0000127)4.58678086
7Thrombocytosis (HP:0001894)4.57135449
8Respiratory distress (HP:0002098)4.41586581
9Abnormality of cells of the erythroid lineage (HP:0012130)3.93039920
10Ragged-red muscle fibers (HP:0003200)3.92543306
11Tubulointerstitial nephritis (HP:0001970)3.91073649
12Microvesicular hepatic steatosis (HP:0001414)3.86910199
13Mitochondrial inheritance (HP:0001427)3.85539120
14Congenital, generalized hypertrichosis (HP:0004540)3.85345923
15Carpal bone hypoplasia (HP:0001498)3.84668933
16Stenosis of the external auditory canal (HP:0000402)3.83211895
17Chronic bronchitis (HP:0004469)3.82249122
18Birth length less than 3rd percentile (HP:0003561)3.79780532
19Reticulocytopenia (HP:0001896)3.78540426
20Breast hypoplasia (HP:0003187)3.76138343
21Type I transferrin isoform profile (HP:0003642)3.73919984
22Increased muscle lipid content (HP:0009058)3.63277114
23Abnormal number of erythroid precursors (HP:0012131)3.51076216
24Hyperactive renin-angiotensin system (HP:0000841)3.51035135
25Increased intramyocellular lipid droplets (HP:0012240)3.46656780
26Abnormal mitochondria in muscle tissue (HP:0008316)3.40382915
27Increased CSF lactate (HP:0002490)3.35173414
28Acute encephalopathy (HP:0006846)3.21640548
29Hyperglycinemia (HP:0002154)3.15682636
30Acute necrotizing encephalopathy (HP:0006965)3.09592049
31Increased serum ferritin (HP:0003281)3.07983182
32Cerebral hypomyelination (HP:0006808)3.05926574
33Dicarboxylic aciduria (HP:0003215)3.01465701
34Abnormality of dicarboxylic acid metabolism (HP:0010995)3.01465701
35Hyperuricemia (HP:0002149)2.93116262
36Increased purine levels (HP:0004368)2.93116262
37Macrocytic anemia (HP:0001972)2.92436425
38Abnormality of the umbilical cord (HP:0010881)2.91958091
39Abnormal protein glycosylation (HP:0012346)2.91282147
40Abnormal glycosylation (HP:0012345)2.91282147
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.91282147
42Abnormal protein N-linked glycosylation (HP:0012347)2.91282147
43Rough bone trabeculation (HP:0100670)2.91252658
44Visual hallucinations (HP:0002367)2.90246783
45Lipid accumulation in hepatocytes (HP:0006561)2.88134702
46Rhabdomyolysis (HP:0003201)2.87738581
47Onycholysis (HP:0001806)2.87333258
48Agammaglobulinemia (HP:0004432)2.86592365
49Increased serum lactate (HP:0002151)2.80274421
50Microretrognathia (HP:0000308)2.78964653
51Lactic acidosis (HP:0003128)2.75328845
52Acute lymphatic leukemia (HP:0006721)2.74548897
53Split foot (HP:0001839)2.74458354
54Tubulointerstitial abnormality (HP:0001969)2.73921563
55Abnormality of the prostate (HP:0008775)2.71276067
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.71169664
57Increased hepatocellular lipid droplets (HP:0006565)2.71140343
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70291274
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70291274
60Chronic obstructive pulmonary disease (HP:0006510)2.69435955
61Obstructive lung disease (HP:0006536)2.69435955
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.69420112
63Tubular atrophy (HP:0000092)2.69170048
64Growth hormone excess (HP:0000845)2.68453571
65Broad metatarsal (HP:0001783)2.67865612
66Petechiae (HP:0000967)2.62368371
67Progressive muscle weakness (HP:0003323)2.59116512
68Oral leukoplakia (HP:0002745)2.57567577
69Exercise intolerance (HP:0003546)2.56569929
70Abnormal umbilical cord blood vessels (HP:0011403)2.54454863
71Single umbilical artery (HP:0001195)2.54454863
72Abnormality of the fetal cardiovascular system (HP:0010948)2.54454863
73Emotional lability (HP:0000712)2.54216062
74Polycythemia (HP:0001901)2.54143838
75Chronic mucocutaneous candidiasis (HP:0002728)2.51170867
76Recurrent cutaneous fungal infections (HP:0011370)2.51170867
77B lymphocytopenia (HP:0010976)2.50695745
78Prolonged neonatal jaundice (HP:0006579)2.50219047
79Cerebral palsy (HP:0100021)2.49747734
80Cerebral edema (HP:0002181)2.47237725
81Achilles tendon contracture (HP:0001771)2.46647385
82Elevated erythrocyte sedimentation rate (HP:0003565)2.46517747
83Abnormality of iron homeostasis (HP:0011031)2.46485442
84Abnormality of the Achilles tendon (HP:0005109)2.44938192
85Recurrent fungal infections (HP:0002841)2.44879168
86Pustule (HP:0200039)2.43844748
87Granulocytopenia (HP:0001913)2.43809691
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41617947
89Pallor (HP:0000980)2.40736490
90Aplasia/Hypoplasia of the hallux (HP:0008362)2.39064327
91Cellulitis (HP:0100658)2.39045170
92Pancytopenia (HP:0001876)2.38458602
93Ureteral duplication (HP:0000073)2.37981362
94Hypertensive crisis (HP:0100735)2.36003390
95Renal Fanconi syndrome (HP:0001994)2.33653448
96Centrally nucleated skeletal muscle fibers (HP:0003687)2.33228635
97Multiple enchondromatosis (HP:0005701)2.27947694
98Steatorrhea (HP:0002570)2.25938346
99Short hallux (HP:0010109)2.24899641
100Severe visual impairment (HP:0001141)2.23890864
101Hyperammonemia (HP:0001987)2.23347386
102Hypergonadotropic hypogonadism (HP:0000815)2.22787907
103Hypotension (HP:0002615)2.22472478
104Absent radius (HP:0003974)2.21937610
105Patellar aplasia (HP:0006443)2.21466441
106Premature skin wrinkling (HP:0100678)2.21173442
107Mediastinal lymphadenopathy (HP:0100721)2.20967267
108Premature ovarian failure (HP:0008209)2.20665783
109Reduced antithrombin III activity (HP:0001976)2.20183557
110Abnormality of B cell number (HP:0010975)2.18876409
111Short chin (HP:0000331)2.18695583
112Skin rash (HP:0000988)2.18426949
113Progressive macrocephaly (HP:0004481)2.18275055
114Aplastic anemia (HP:0001915)2.18065810
115Aplasia/Hypoplasia of the patella (HP:0006498)2.16021510
116Abnormal hemoglobin (HP:0011902)2.14067541
117Abnormality of the parathyroid morphology (HP:0011766)2.12790913
118Panhypogammaglobulinemia (HP:0003139)2.11800305
119Glomerulosclerosis (HP:0000096)2.09772328
120Absent forearm bone (HP:0003953)2.08029874
121Aplasia involving forearm bones (HP:0009822)2.08029874
122Stomach cancer (HP:0012126)2.06414886
123Neurofibrillary tangles (HP:0002185)2.06349294
124Hyperglycinuria (HP:0003108)2.06347352
125Lethargy (HP:0001254)2.06282604
126Pili torti (HP:0003777)2.06102097
127Thoracic kyphosis (HP:0002942)2.05979798
128Selective tooth agenesis (HP:0001592)2.05969790
129Abnormality of transition element cation homeostasis (HP:0011030)2.05801048
130Opisthotonus (HP:0002179)2.05287584
131Neonatal respiratory distress (HP:0002643)2.05125272
132Hypertriglyceridemia (HP:0002155)2.05117009
133Colon cancer (HP:0003003)2.04769504
134Exercise-induced myalgia (HP:0003738)2.04739286
135Hyponatremia (HP:0002902)2.04542295
136Degeneration of anterior horn cells (HP:0002398)2.04194291
137Abnormality of the anterior horn cell (HP:0006802)2.04194291
138Dry hair (HP:0011359)2.03646309
139Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03243707
140Spastic paraparesis (HP:0002313)2.02805647
141Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01159427
142Interstitial pulmonary disease (HP:0006530)10.4147257
143Testicular atrophy (HP:0000029)1.99619034
144Epistaxis (HP:0000421)1.99494192
145Secondary amenorrhea (HP:0000869)1.98625851
146Trismus (HP:0000211)1.98490385
147Glossoptosis (HP:0000162)1.98129072
148Abnormality of male internal genitalia (HP:0000022)1.98057617
149Patent foramen ovale (HP:0001655)1.97854357
150Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97791119
151Abnormal trabecular bone morphology (HP:0100671)1.96528773
152Abnormality of subcutaneous fat tissue (HP:0001001)1.95556898
153Failure to thrive in infancy (HP:0001531)1.93846562
154Ulnar bowing (HP:0003031)1.93685489
155Sparse eyelashes (HP:0000653)1.93530793
156Absent thumb (HP:0009777)1.92780645
157Osteolytic defects of the phalanges of the hand (HP:0009771)1.92694178
158Osteolytic defects of the hand bones (HP:0009699)1.92694178
159Personality changes (HP:0000751)1.91533726
160Metabolic acidosis (HP:0001942)1.91415086
161Abnormality of serine family amino acid metabolism (HP:0010894)1.91236928
162Abnormality of glycine metabolism (HP:0010895)1.91236928
163Prostate neoplasm (HP:0100787)1.91175910
164Abnormality of the labia minora (HP:0012880)1.90103456
165Seborrheic dermatitis (HP:0001051)1.88249127
166Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87500553
167Meningitis (HP:0001287)1.87040585
168Bronchitis (HP:0012387)1.85517330
169Fatigue (HP:0012378)1.85403953
170Impulsivity (HP:0100710)1.82736898
171Respiratory failure (HP:0002878)1.82511200
172Decreased subcutaneous fat (HP:0001002)1.82051971
173Ventricular fibrillation (HP:0001663)1.80511965
174Thyroid-stimulating hormone excess (HP:0002925)1.79139971
175Broad distal phalanx of finger (HP:0009836)1.77062131
176Abnormalities of placenta or umbilical cord (HP:0001194)1.76351946
177Abnormality of the distal phalanges of the toes (HP:0010182)1.74757559
178Neoplasm of the pancreas (HP:0002894)1.72177721
179Absent toe (HP:0010760)1.70692084
180Death in infancy (HP:0001522)1.70000308
181Hematochezia (HP:0002573)1.66591517
182Abnormality of the nasal mucosa (HP:0000433)1.65511770
183CNS hypomyelination (HP:0003429)1.65202800
184Atresia of the external auditory canal (HP:0000413)1.65078924
185Conjunctival telangiectasia (HP:0000524)1.63809068
186Fragile nails (HP:0001808)1.63538608
187Bowed forearm bones (HP:0003956)1.62445862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.23394516
2TESK24.75673764
3BUB14.44554550
4BCKDK3.32147225
5WEE13.07652626
6EPHA22.84153286
7NME22.80383478
8STK242.69425415
9TSSK62.58339757
10ZAP702.45780751
11PAK42.40440835
12MAP2K22.20294156
13LRRK22.20075881
14TIE12.14635468
15MST42.09142663
16SMG11.93421038
17PIM21.93105618
18VRK11.91571667
19NEK21.91214298
20CDC71.87884291
21ILK1.86928578
22TAOK21.85608944
23NUAK11.80302840
24STK161.77016673
25SRPK11.69842929
26EIF2AK31.64650344
27PLK11.61882603
28CDK121.60289944
29TRIB31.56949380
30PLK41.55765177
31ERN11.51337600
32FGFR21.43709668
33MAP4K11.41858313
34RPS6KA41.40631352
35PLK31.38888036
36DYRK31.37617966
37IRAK31.37586189
38FLT31.37263025
39TAOK31.37152547
40STK101.32910442
41AURKB1.32606243
42KIT1.32192453
43MYLK1.24861669
44MAPK151.23235015
45MAP3K111.19050628
46MAP3K81.19050494
47CDK71.16525676
48MKNK21.13758024
49AKT31.13215687
50CDK61.12271715
51DAPK11.10687145
52RAF11.08800487
53TAF11.07881121
54TTK1.06381673
55CDK91.04552956
56TESK11.04124322
57PBK1.03310455
58ALK1.01061449
59PRKCI0.99241496
60RPS6KB20.97892971
61AURKA0.94000242
62GRK60.92929532
63PNCK0.92776407
64NEK90.92626780
65MAP3K30.91752805
66TGFBR20.91140213
67ACVR1B0.90397518
68EIF2AK10.89555952
69PRPF4B0.89461938
70KDR0.89414439
71BRSK20.83788445
72CDK40.81588064
73MKNK10.81288900
74ABL20.78844015
75CDK80.77496843
76MAP2K30.76986236
77ICK0.76275893
78LATS10.75655969
79SCYL20.74575963
80GSK3A0.73263712
81TBK10.72817827
82NME10.72135021
83PDGFRB0.71032959
84GRK10.69634068
85CCNB10.69105593
86CSNK2A10.68500259
87MAPK40.66719392
88CSNK2A20.65876990
89PAK20.62776260
90DAPK20.58497837
91EIF2AK20.58161202
92CSF1R0.58025230
93PIM10.57168704
94CHEK20.56868168
95JAK30.54943619
96PINK10.54809853
97MAPKAPK50.53508295
98RPS6KA50.50367495
99DAPK30.49451478
100STK390.48038344
101PKN20.47482723
102RPS6KA60.47267035
103MAP3K10.46885966
104BRAF0.45802289
105ARAF0.45693769
106PDK20.45607280
107TAOK10.44875907
108TEC0.44056299
109AKT20.42382607
110IKBKB0.42171826
111MAP2K60.41215528
112MET0.40456013
113ATR0.39971362
114CHEK10.39946719
115CSNK1E0.39775199
116MAP3K50.38678975
117TGFBR10.38425302
118DYRK20.37971702
119FER0.37315187
120NEK10.37229060
121GRK50.35851002
122MTOR0.35780575
123ZAK0.35309583
124GRK70.34967530
125MATK0.34699485
126EGFR0.33649679
127FES0.31887111
128CDK20.30590576
129PAK10.30536201
130AKT10.30212630
131MAPK110.29738590
132ATM0.29645369
133STK40.29627879
134BTK0.29544653
135LATS20.29057642
136RPS6KL10.28919664
137RPS6KC10.28919664
138ADRBK10.27317145
139TNK20.25838241
140CDK10.24908699
141EEF2K0.24694171
142MAP3K60.21962681
143HIPK20.21417760

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.59803011
2DNA replication_Homo sapiens_hsa030303.95735412
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.93094229
4RNA polymerase_Homo sapiens_hsa030203.62733578
5Vitamin B6 metabolism_Homo sapiens_hsa007503.23886054
6Proteasome_Homo sapiens_hsa030503.18269991
7Folate biosynthesis_Homo sapiens_hsa007902.96974805
8Mismatch repair_Homo sapiens_hsa034302.87023593
9RNA transport_Homo sapiens_hsa030132.67621142
10Pancreatic secretion_Homo sapiens_hsa049722.65416040
11Spliceosome_Homo sapiens_hsa030402.42898263
12Pyrimidine metabolism_Homo sapiens_hsa002402.41219171
13Base excision repair_Homo sapiens_hsa034102.39779074
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.18133479
15Phenylalanine metabolism_Homo sapiens_hsa003602.08590491
16Protein export_Homo sapiens_hsa030602.05519237
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03971061
18Protein digestion and absorption_Homo sapiens_hsa049741.88590175
19Nucleotide excision repair_Homo sapiens_hsa034201.78869676
20Cell cycle_Homo sapiens_hsa041101.69487312
21One carbon pool by folate_Homo sapiens_hsa006701.68567317
22Fat digestion and absorption_Homo sapiens_hsa049751.68556737
23Parkinsons disease_Homo sapiens_hsa050121.68292161
24Homologous recombination_Homo sapiens_hsa034401.60786780
25Sulfur relay system_Homo sapiens_hsa041221.55219866
26Purine metabolism_Homo sapiens_hsa002301.47620910
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.40863862
28Arginine and proline metabolism_Homo sapiens_hsa003301.33221375
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31015791
30p53 signaling pathway_Homo sapiens_hsa041151.29290697
31Vitamin digestion and absorption_Homo sapiens_hsa049771.22753594
32Tyrosine metabolism_Homo sapiens_hsa003501.22582273
33Mineral absorption_Homo sapiens_hsa049781.22487737
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19007022
35Glutathione metabolism_Homo sapiens_hsa004801.18603944
36Other glycan degradation_Homo sapiens_hsa005111.14712234
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13567613
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13005818
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.12187475
40Peroxisome_Homo sapiens_hsa041461.10836085
41Butanoate metabolism_Homo sapiens_hsa006501.10295137
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09833325
43Fatty acid degradation_Homo sapiens_hsa000711.08667020
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.05592565
45RNA degradation_Homo sapiens_hsa030181.05196636
46Primary immunodeficiency_Homo sapiens_hsa053401.04227739
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.02957847
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01813749
49Alzheimers disease_Homo sapiens_hsa050100.99677381
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99266892
51Pentose phosphate pathway_Homo sapiens_hsa000300.97131692
52Renin-angiotensin system_Homo sapiens_hsa046140.97095331
53Epstein-Barr virus infection_Homo sapiens_hsa051690.94290334
54Fatty acid metabolism_Homo sapiens_hsa012120.93160015
55Biosynthesis of amino acids_Homo sapiens_hsa012300.93143859
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90009871
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89798750
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89354427
59Small cell lung cancer_Homo sapiens_hsa052220.88702407
60Glycerolipid metabolism_Homo sapiens_hsa005610.88310008
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88036823
62Fanconi anemia pathway_Homo sapiens_hsa034600.86231774
63Thyroid cancer_Homo sapiens_hsa052160.83426909
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81140108
65Tight junction_Homo sapiens_hsa045300.80314910
66Pyruvate metabolism_Homo sapiens_hsa006200.78992992
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75727533
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74721958
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73721986
70Bladder cancer_Homo sapiens_hsa052190.67643190
71Lysosome_Homo sapiens_hsa041420.64814599
72Basal transcription factors_Homo sapiens_hsa030220.64076905
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62219685
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61790114
75Selenocompound metabolism_Homo sapiens_hsa004500.61368819
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60839468
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.58517449
78Shigellosis_Homo sapiens_hsa051310.57137791
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54700444
80Regulation of autophagy_Homo sapiens_hsa041400.52732387
81Hippo signaling pathway_Homo sapiens_hsa043900.50592399
82Ether lipid metabolism_Homo sapiens_hsa005650.49137970
83Sulfur metabolism_Homo sapiens_hsa009200.48264961
84Arginine biosynthesis_Homo sapiens_hsa002200.45990620
85Notch signaling pathway_Homo sapiens_hsa043300.45942761
86Fatty acid biosynthesis_Homo sapiens_hsa000610.44755233
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.44464062
88Metabolic pathways_Homo sapiens_hsa011000.43455142
89Asthma_Homo sapiens_hsa053100.42322540
90Steroid biosynthesis_Homo sapiens_hsa001000.41854273
91Tryptophan metabolism_Homo sapiens_hsa003800.40054999
92Antigen processing and presentation_Homo sapiens_hsa046120.39519247
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.38985352
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38542792
95Oocyte meiosis_Homo sapiens_hsa041140.38201522
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37850826
97Vibrio cholerae infection_Homo sapiens_hsa051100.37451526
98Arachidonic acid metabolism_Homo sapiens_hsa005900.36611869
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36025802
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35873686
101Viral carcinogenesis_Homo sapiens_hsa052030.34860657
102N-Glycan biosynthesis_Homo sapiens_hsa005100.33677703
103mRNA surveillance pathway_Homo sapiens_hsa030150.32269889
104Adherens junction_Homo sapiens_hsa045200.31739767
105Complement and coagulation cascades_Homo sapiens_hsa046100.31473128
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30852739
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30491217
108HTLV-I infection_Homo sapiens_hsa051660.30129277
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29655346
110Non-homologous end-joining_Homo sapiens_hsa034500.29113089
111ECM-receptor interaction_Homo sapiens_hsa045120.28986360
112Retinol metabolism_Homo sapiens_hsa008300.27798990
113Chemical carcinogenesis_Homo sapiens_hsa052040.27734656
114Fatty acid elongation_Homo sapiens_hsa000620.26967373
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26572892
116Huntingtons disease_Homo sapiens_hsa050160.24810568
117Systemic lupus erythematosus_Homo sapiens_hsa053220.24681081
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24169886
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23670988
120Fructose and mannose metabolism_Homo sapiens_hsa000510.22975060
121Caffeine metabolism_Homo sapiens_hsa002320.22008882
122Linoleic acid metabolism_Homo sapiens_hsa005910.21839501
123Propanoate metabolism_Homo sapiens_hsa006400.21827682
124Apoptosis_Homo sapiens_hsa042100.21759997
125Pathways in cancer_Homo sapiens_hsa052000.21488812
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.21140337
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20543602
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20285472
129MicroRNAs in cancer_Homo sapiens_hsa052060.19409380
130Acute myeloid leukemia_Homo sapiens_hsa052210.19115974
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18463311
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18068041
133Carbon metabolism_Homo sapiens_hsa012000.17027283
134Lysine degradation_Homo sapiens_hsa003100.16696778
135Leishmaniasis_Homo sapiens_hsa051400.16211905
136Prostate cancer_Homo sapiens_hsa052150.15576007
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15223087
138Legionellosis_Homo sapiens_hsa051340.14641941
139Herpes simplex infection_Homo sapiens_hsa051680.14334933
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14078407
141Oxidative phosphorylation_Homo sapiens_hsa001900.12479580
142Influenza A_Homo sapiens_hsa051640.12155432

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