NPY1R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of epidermal cell differentiation (GO:0045606)8.53169563
2regulation of keratinocyte differentiation (GO:0045616)6.37632481
3vocalization behavior (GO:0071625)5.84496184
4positive regulation of osteoclast differentiation (GO:0045672)5.73388973
5neuron cell-cell adhesion (GO:0007158)5.41996024
6presynaptic membrane assembly (GO:0097105)5.13257142
7intestinal epithelial cell development (GO:0060576)5.06969138
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.06275705
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.02965919
10positive regulation of epidermis development (GO:0045684)4.95970549
11cardiac right ventricle morphogenesis (GO:0003215)4.88645355
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.87636281
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.77127751
14neurotransmitter-gated ion channel clustering (GO:0072578)4.74170890
15positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)4.72836868
16regulation of glutamate receptor signaling pathway (GO:1900449)4.67437631
17postsynaptic membrane organization (GO:0001941)4.66187289
18protein localization to synapse (GO:0035418)4.60734727
19triglyceride catabolic process (GO:0019433)4.59121071
20presynaptic membrane organization (GO:0097090)4.59112777
21prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.44371842
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.41959113
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.35221783
24synaptic vesicle exocytosis (GO:0016079)4.21270862
25locomotory exploration behavior (GO:0035641)4.20572555
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.18212751
27glutamate receptor signaling pathway (GO:0007215)4.15552982
28synaptic transmission, glutamatergic (GO:0035249)4.10208438
29glutamate secretion (GO:0014047)4.09949454
30gamma-aminobutyric acid signaling pathway (GO:0007214)4.06812535
31neuron-neuron synaptic transmission (GO:0007270)4.03678064
32acylglycerol catabolic process (GO:0046464)4.03349940
33neutral lipid catabolic process (GO:0046461)4.03349940
34positive regulation of insulin receptor signaling pathway (GO:0046628)4.02747193
35startle response (GO:0001964)4.01605122
36dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.94902265
37endocrine hormone secretion (GO:0060986)3.94379970
38positive regulation of cellular response to insulin stimulus (GO:1900078)3.91733143
39regulation of synaptic vesicle exocytosis (GO:2000300)3.79070060
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.78464698
41keratinocyte development (GO:0003334)3.77618083
42ear development (GO:0043583)3.75713984
43negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.67559261
44regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.67340907
45regulation of epidermal cell differentiation (GO:0045604)3.65185244
46biotin metabolic process (GO:0006768)3.64868991
47neuronal action potential propagation (GO:0019227)3.64643656
48epithelial cell maturation (GO:0002070)3.62900110
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61677728
50regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)3.59869241
51cardiac ventricle morphogenesis (GO:0003208)3.59525426
52low-density lipoprotein particle clearance (GO:0034383)3.59122768
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.57178424
54neuron recognition (GO:0008038)3.56661971
55exploration behavior (GO:0035640)3.55442242
56transcytosis (GO:0045056)3.51886815
57uterus development (GO:0060065)3.51516019
58response to dietary excess (GO:0002021)3.50376784
59positive regulation of glomerulus development (GO:0090193)3.49014191
60transmission of nerve impulse (GO:0019226)3.48769241
61regulation of synaptic vesicle transport (GO:1902803)3.46418419
62response to histamine (GO:0034776)3.46234699
63positive regulation of synapse assembly (GO:0051965)3.44667293
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.44576223
65regulation of synapse maturation (GO:0090128)3.42267753
66regulation of postsynaptic membrane potential (GO:0060078)3.41500515
67regulation of water loss via skin (GO:0033561)3.39804391
68response to water (GO:0009415)3.39720935
69regulation of neuronal synaptic plasticity (GO:0048168)3.39047737
70long-term synaptic potentiation (GO:0060291)3.38666366
71regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32494927
72lipid particle organization (GO:0034389)3.31632238
73long-term memory (GO:0007616)3.31354953
74positive regulation of synapse maturation (GO:0090129)3.31194343
75norepinephrine metabolic process (GO:0042415)3.28283181
76NADH metabolic process (GO:0006734)3.28247420
77neurotransmitter secretion (GO:0007269)3.27836927
78synaptic vesicle endocytosis (GO:0048488)3.26582433
79positive regulation of neurotransmitter secretion (GO:0001956)3.25326044
80positive regulation of membrane potential (GO:0045838)3.24684850
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.23213603
82synaptic vesicle maturation (GO:0016188)3.23212783
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23041450
84axonal fasciculation (GO:0007413)3.22734697
85cardiac chamber morphogenesis (GO:0003206)3.18900362
86regulation of cell proliferation involved in kidney development (GO:1901722)3.18700953
87cellular response to lithium ion (GO:0071285)3.17298265
88synapse assembly (GO:0007416)3.14302611
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.13939340
90regulation of sequestering of triglyceride (GO:0010889)3.12885243
91regulation of neurotransmitter secretion (GO:0046928)3.12422894
92maternal placenta development (GO:0001893)3.09212778
93regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.07980165
94adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.07916228
95positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06794703
96learning (GO:0007612)3.05849570
97regulation of synaptic plasticity (GO:0048167)3.05194061
98regulation of synapse assembly (GO:0051963)3.04763601
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02917107
100behavioral defense response (GO:0002209)3.01992665
101behavioral fear response (GO:0001662)3.01992665
102regulation of establishment or maintenance of cell polarity (GO:0032878)3.01779130
103serotonin receptor signaling pathway (GO:0007210)3.01536041
104regulation of vesicle fusion (GO:0031338)2.99870391
105regulation of cAMP-dependent protein kinase activity (GO:2000479)2.98682605
106negative regulation of kidney development (GO:0090185)2.98143263
107positive regulation of neurotransmitter transport (GO:0051590)2.97717458
108regulation of establishment of cell polarity (GO:2000114)2.96812669
109trophectodermal cell differentiation (GO:0001829)2.96641900
110positive regulation of glucose import (GO:0046326)2.96148340
111anterior/posterior axis specification, embryo (GO:0008595)2.94537977
112fear response (GO:0042596)2.94024060
113membrane depolarization (GO:0051899)2.93778022
114neurotransmitter transport (GO:0006836)2.91431672
115dendritic spine morphogenesis (GO:0060997)2.89503307
116mechanosensory behavior (GO:0007638)2.88947636
117regulation of glutamate secretion (GO:0014048)2.87638726
118negative regulation of organic acid transport (GO:0032891)2.87042040
119positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.87003179
120endothelium development (GO:0003158)2.86449494
121regulation of epidermis development (GO:0045682)2.86387966
122response to vitamin E (GO:0033197)2.86005965
123negative regulation of amine transport (GO:0051953)2.85964384
124cerebellar granule cell differentiation (GO:0021707)2.85913987
125auditory behavior (GO:0031223)2.85674443
126detection of calcium ion (GO:0005513)2.85461597
127regulation of synaptic transmission, GABAergic (GO:0032228)2.84609396
128dendrite development (GO:0016358)2.84598473
129regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83553793
130positive regulation of synaptic transmission (GO:0050806)2.83525982
131synaptic transmission (GO:0007268)2.82613045
132glycerolipid catabolic process (GO:0046503)2.80708718
133polyol transport (GO:0015791)2.80127099
134prostate gland growth (GO:0060736)2.79731170
135regulation of neurotransmitter transport (GO:0051588)2.79463576
136tight junction assembly (GO:0070830)2.78390309
137regulation of mammary gland epithelial cell proliferation (GO:0033599)2.77666222
138ovulation from ovarian follicle (GO:0001542)2.77439530
139regulation of synaptic transmission (GO:0050804)2.75830912
140positive regulation of epithelial cell differentiation (GO:0030858)2.75432709
141protein localization to cilium (GO:0061512)2.75033305
142gamma-aminobutyric acid transport (GO:0015812)2.74435002
143regulation of glomerular filtration (GO:0003093)2.74300920
144protein complex localization (GO:0031503)2.73966387
145membrane depolarization during action potential (GO:0086010)2.73765399
146central nervous system projection neuron axonogenesis (GO:0021952)2.72211886
147neuronal ion channel clustering (GO:0045161)2.71322272
148regulation of respiratory system process (GO:0044065)2.69391202
149endocardial cushion development (GO:0003197)2.69033907
150regulation of axon extension involved in axon guidance (GO:0048841)2.68704066
151protein heterotrimerization (GO:0070208)2.68046809
152negative regulation of transcription by competitive promoter binding (GO:0010944)2.67924437
153negative regulation of dendrite morphogenesis (GO:0050774)2.67866638
154regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.67814841
155regulation of synapse structural plasticity (GO:0051823)2.67632376
156regulation of inositol phosphate biosynthetic process (GO:0010919)2.67613669
157regulation of synapse organization (GO:0050807)2.67151630
158regulation of respiratory gaseous exchange (GO:0043576)2.66402465
159behavioral response to cocaine (GO:0048148)2.65516356
160regulation of glucose import in response to insulin stimulus (GO:2001273)2.64914504
161cochlea development (GO:0090102)2.62666929
162membrane assembly (GO:0071709)2.62627509
163adult behavior (GO:0030534)2.61905719
164opioid receptor signaling pathway (GO:0038003)2.61341512
165lung lobe morphogenesis (GO:0060463)2.60527758
166associative learning (GO:0008306)2.59843389
167righting reflex (GO:0060013)2.58504143
168response to auditory stimulus (GO:0010996)2.57908759
169negative regulation of amino acid transport (GO:0051956)2.57365807
170negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.54732680
171fatty acid elongation (GO:0030497)2.53047697
172epithelial cell differentiation involved in prostate gland development (GO:0060742)2.52499999
173regulation of protein localization to cell surface (GO:2000008)2.52149428
174trivalent inorganic anion homeostasis (GO:0072506)2.51573378
175phosphate ion homeostasis (GO:0055062)2.51573378
176genitalia morphogenesis (GO:0035112)2.50513674
177limb bud formation (GO:0060174)2.50145558
178facial nerve structural organization (GO:0021612)2.49350771
179apical protein localization (GO:0045176)2.49339133
180ethanol oxidation (GO:0006069)2.49121489
181regulation of glomerulus development (GO:0090192)2.48977450
182mammary gland epithelial cell proliferation (GO:0033598)2.48924255
183multicellular organismal water homeostasis (GO:0050891)2.48442576
184positive regulation of glucose transport (GO:0010828)2.47283771
185regulation of centriole replication (GO:0046599)2.47093707
186cellular response to leptin stimulus (GO:0044320)2.45479602
187protein localization to cell surface (GO:0034394)2.44993565
188pre-miRNA processing (GO:0031054)2.44736243
189mammary gland epithelial cell differentiation (GO:0060644)2.44514929
190cellular response to antibiotic (GO:0071236)2.42856812
191sympathetic nervous system development (GO:0048485)2.41063115
192organ growth (GO:0035265)2.40450446
193branching involved in prostate gland morphogenesis (GO:0060442)2.37540461
194cardiac left ventricle morphogenesis (GO:0003214)2.37421617
195regulation of amino acid transport (GO:0051955)2.37160168
196insulin-like growth factor receptor signaling pathway (GO:0048009)2.36647335
197positive regulation of keratinocyte differentiation (GO:0045618)12.7989381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human6.98084230
2EZH2_22144423_ChIP-Seq_EOC_Human6.04871976
3ESR1_21235772_ChIP-Seq_MCF-7_Human5.83559091
4ESR2_21235772_ChIP-Seq_MCF-7_Human4.74635429
5GBX2_23144817_ChIP-Seq_PC3_Human4.29040690
6ESR1_15608294_ChIP-ChIP_MCF-7_Human4.17370847
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.72106918
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96408990
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87868704
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87436614
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83248261
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60585205
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52829478
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.50669642
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.47095579
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44832562
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43586945
18TAF15_26573619_Chip-Seq_HEK293_Human2.43371401
19* GATA3_24758297_ChIP-Seq_MCF-7_Human2.42646779
20CLOCK_20551151_ChIP-Seq_293T_Human2.42439183
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40646195
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40646195
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39314266
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.35961635
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34071629
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32590089
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15961394
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15817301
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12621358
30BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08484323
31REST_21632747_ChIP-Seq_MESCs_Mouse2.06480339
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.04262676
33FOXM1_26456572_ChIP-Seq_MCF-7_Human2.03140013
34RUNX1_27514584_Chip-Seq_MCF-7_Human2.01615773
35RNF2_27304074_Chip-Seq_ESCs_Mouse2.01122033
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00075152
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99534645
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.98448478
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92009630
40P300_19829295_ChIP-Seq_ESCs_Human1.89237192
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.86039108
42SMAD4_21799915_ChIP-Seq_A2780_Human1.83793545
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83730881
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.83577986
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81551920
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79439822
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.79004321
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.79004321
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.79004321
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78856686
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78690953
52DROSHA_22980978_ChIP-Seq_HELA_Human1.76556191
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74895497
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71986383
55AR_21572438_ChIP-Seq_LNCaP_Human1.66638133
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.66265994
57IGF1R_20145208_ChIP-Seq_DFB_Human1.59902033
58FUS_26573619_Chip-Seq_HEK293_Human1.58705112
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57846205
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.57825312
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55705991
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54572615
63RNF2_27304074_Chip-Seq_NSC_Mouse1.54457186
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.54244769
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.54145627
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53592256
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53314269
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.52770778
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.49220154
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43928926
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.43841504
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.41532430
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38942374
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37514598
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37179390
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35473447
77* AR_25329375_ChIP-Seq_VCAP_Human1.34492572
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33760636
79ER_23166858_ChIP-Seq_MCF-7_Human1.33319548
80* ELF5_23300383_ChIP-Seq_T47D_Human1.33283751
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32879544
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32217649
83VDR_22108803_ChIP-Seq_LS180_Human1.32162742
84STAT3_23295773_ChIP-Seq_U87_Human1.31884397
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31758184
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.31750112
87ZNF263_19887448_ChIP-Seq_K562_Human1.30787290
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.30127571
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29827325
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29818912
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27432733
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26367748
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25832254
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25730700
95* TCF4_23295773_ChIP-Seq_U87_Human1.25168652
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24557550
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.20932469
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20812912
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20271449
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19071933
101TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19042201
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18842259
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.18735723
104TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18672608
105RUNX2_22187159_ChIP-Seq_PCA_Human1.17467197
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17300067
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15834111
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14452870
109TP53_18474530_ChIP-ChIP_U2OS_Human1.13949152
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.13648023
111P53_22387025_ChIP-Seq_ESCs_Mouse1.13288685
112* JUN_21703547_ChIP-Seq_K562_Human1.12662587
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11170163
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.10491543
115P300_18555785_Chip-Seq_ESCs_Mouse1.10417299
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10098400
117EWS_26573619_Chip-Seq_HEK293_Human1.09859630
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.08425413
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08259893
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.08001317
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.07713564
122RACK7_27058665_Chip-Seq_MCF-7_Human1.07531605
123KDM2B_26808549_Chip-Seq_REH_Human1.07106190
124KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07092581
125NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06985578
126GATA1_22025678_ChIP-Seq_K562_Human1.06674281
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06281290
128KLF4_18555785_Chip-Seq_ESCs_Mouse1.05688561
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05430075
130AHR_22903824_ChIP-Seq_MCF-7_Human1.04568976
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04266296
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04254943
133* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03142883
134NFE2_27457419_Chip-Seq_LIVER_Mouse1.02779363
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.02465832
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01500679
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01500679
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01475219
139NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00611360
140ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99391988
141SOX2_18555785_Chip-Seq_ESCs_Mouse0.99208162
142ZNF274_21170338_ChIP-Seq_K562_Hela0.98790128
143NMYC_18555785_Chip-Seq_ESCs_Mouse0.97681529
144ZFX_18555785_Chip-Seq_ESCs_Mouse0.97588612
145* AR_19668381_ChIP-Seq_PC3_Human0.97577607
146WT1_19549856_ChIP-ChIP_CCG9911_Human0.97244213
147* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97055101
148SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96930833
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.96426236
150AR_21909140_ChIP-Seq_LNCAP_Human0.94885600
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94862416
152PU1_27457419_Chip-Seq_LIVER_Mouse0.88817093
153KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87649792
154FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85882389
155CTCF_18555785_Chip-Seq_ESCs_Mouse0.85838194
156NANOG_16153702_ChIP-ChIP_HESCs_Human0.85095831
157FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85066812
158RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84097505
159SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83410991
160SMAD3_21741376_ChIP-Seq_HESCs_Human0.81440461
161NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80578817
162PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79197291
163TP53_20018659_ChIP-ChIP_R1E_Mouse0.78262307
164ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78056470
165ISL1_27105846_Chip-Seq_CPCs_Mouse0.78002189
166TCF4_18268006_ChIP-ChIP_LS174T_Human0.76610185
167CHD1_26751641_Chip-Seq_LNCaP_Human0.74877399
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.73884414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.81440567
2MP0003880_abnormal_central_pattern4.56310582
3MP0003941_abnormal_skin_development4.36183787
4MP0005670_abnormal_white_adipose4.04325243
5MP0002796_impaired_skin_barrier3.69875849
6MP0003635_abnormal_synaptic_transmissio3.45411246
7MP0004264_abnormal_extraembryonic_tissu3.44062456
8MP0009384_cardiac_valve_regurgitation3.39680691
9* MP0009745_abnormal_behavioral_response3.32539106
10MP0001968_abnormal_touch/_nociception3.11493811
11MP0002735_abnormal_chemical_nociception2.96989436
12* MP0002063_abnormal_learning/memory/cond2.86181447
13MP0004270_analgesia2.84308271
14MP0002064_seizures2.75512889
15* MP0005666_abnormal_adipose_tissue2.70230886
16* MP0002572_abnormal_emotion/affect_behav2.68306312
17MP0001188_hyperpigmentation2.59001833
18MP0002822_catalepsy2.50207874
19MP0002736_abnormal_nociception_after2.46536267
20MP0006276_abnormal_autonomic_nervous2.45642132
21MP0010386_abnormal_urinary_bladder2.44300492
22MP0009046_muscle_twitch2.41168723
23MP0001501_abnormal_sleep_pattern2.37441193
24MP0001486_abnormal_startle_reflex2.37091732
25MP0005423_abnormal_somatic_nervous2.34680574
26MP0002272_abnormal_nervous_system2.33804961
27MP0000537_abnormal_urethra_morphology2.32279258
28MP0001440_abnormal_grooming_behavior2.31317371
29MP0002734_abnormal_mechanical_nocicepti2.31080473
30MP0000383_abnormal_hair_follicle2.28089435
31MP0005646_abnormal_pituitary_gland2.16120814
32MP0003787_abnormal_imprinting2.13651882
33MP0000462_abnormal_digestive_system2.05944352
34MP0005503_abnormal_tendon_morphology2.05800777
35MP0000427_abnormal_hair_cycle2.04228683
36MP0003890_abnormal_embryonic-extraembry1.93884961
37MP0005645_abnormal_hypothalamus_physiol1.93187954
38* MP0002067_abnormal_sensory_capabilities1.91555360
39MP0000627_abnormal_mammary_gland1.89745456
40MP0005408_hypopigmentation1.87542909
41MP0001970_abnormal_pain_threshold1.83612102
42* MP0005375_adipose_tissue_phenotype1.83489274
43MP0006292_abnormal_olfactory_placode1.81231060
44MP0003879_abnormal_hair_cell1.79695923
45* MP0002557_abnormal_social/conspecific_i1.78194149
46MP0005501_abnormal_skin_physiology1.78129587
47MP0005171_absent_coat_pigmentation1.77473127
48MP0002733_abnormal_thermal_nociception1.77230204
49MP0005083_abnormal_biliary_tract1.75965139
50MP0002184_abnormal_innervation1.74920158
51MP0000778_abnormal_nervous_system1.71460336
52MP0002971_abnormal_brown_adipose1.68793286
53MP0010678_abnormal_skin_adnexa1.67708551
54MP0009672_abnormal_birth_weight1.67636238
55MP0001905_abnormal_dopamine_level1.64948238
56MP0002876_abnormal_thyroid_physiology1.63534564
57MP0001881_abnormal_mammary_gland1.61386047
58MP0003122_maternal_imprinting1.59707614
59MP0004742_abnormal_vestibular_system1.59649035
60MP0005248_abnormal_Harderian_gland1.59199883
61MP0004782_abnormal_surfactant_physiolog1.58717691
62MP0001984_abnormal_olfaction1.58157713
63MP0004130_abnormal_muscle_cell1.57326588
64MP0005076_abnormal_cell_differentiation1.52088161
65MP0006138_congestive_heart_failure1.50579636
66* MP0004185_abnormal_adipocyte_glucose1.50128122
67MP0009115_abnormal_fat_cell1.49744443
68MP0003011_delayed_dark_adaptation1.47449061
69MP0005386_behavior/neurological_phenoty1.44139892
70MP0004924_abnormal_behavior1.44139892
71MP0001502_abnormal_circadian_rhythm1.43929758
72MP0003936_abnormal_reproductive_system1.41255939
73MP0001986_abnormal_taste_sensitivity1.40896878
74MP0009780_abnormal_chondrocyte_physiolo1.39989199
75MP0002108_abnormal_muscle_morphology1.37892834
76MP0001727_abnormal_embryo_implantation1.35679418
77MP0005275_abnormal_skin_tensile1.34638031
78MP0001963_abnormal_hearing_physiology1.33216360
79MP0008569_lethality_at_weaning1.32930810
80MP0000579_abnormal_nail_morphology1.30890229
81MP0004885_abnormal_endolymph1.30847484
82MP0002837_dystrophic_cardiac_calcinosis1.29046602
83MP0005187_abnormal_penis_morphology1.28656840
84MP0009703_decreased_birth_body1.26784096
85MP0003315_abnormal_perineum_morphology1.26011511
86MP0002098_abnormal_vibrissa_morphology1.23709671
87MP0001529_abnormal_vocalization1.23264436
88MP0004381_abnormal_hair_follicle1.20200902
89* MP0002882_abnormal_neuron_morphology1.19732672
90MP0005551_abnormal_eye_electrophysiolog1.18461787
91MP0004142_abnormal_muscle_tone1.18309180
92MP0003221_abnormal_cardiomyocyte_apopto1.16517806
93MP0002009_preneoplasia1.16428114
94MP0001485_abnormal_pinna_reflex1.15269637
95* MP0002066_abnormal_motor_capabilities/c1.15192938
96MP0002102_abnormal_ear_morphology1.13219131
97MP0002970_abnormal_white_adipose1.12621045
98MP0010030_abnormal_orbit_morphology1.11924862
99MP0003191_abnormal_cellular_cholesterol1.10891581
100MP0004811_abnormal_neuron_physiology1.10386163
101MP0000026_abnormal_inner_ear1.10252222
102MP0000377_abnormal_hair_follicle1.09144397
103* MP0005334_abnormal_fat_pad1.07907095
104MP0003566_abnormal_cell_adhesion1.06356544
105MP0000467_abnormal_esophagus_morphology1.06211005
106MP0004858_abnormal_nervous_system1.05027847
107MP0003942_abnormal_urinary_system1.04356079
108MP0010329_abnormal_lipoprotein_level1.04296611
109MP0000955_abnormal_spinal_cord1.04011545
110MP0002638_abnormal_pupillary_reflex1.03783334
111MP0002160_abnormal_reproductive_system1.03131605
112MP0000569_abnormal_digit_pigmentation1.03104162
113MP0000015_abnormal_ear_pigmentation1.02737282
114MP0000631_abnormal_neuroendocrine_gland0.99243167
115MP0004145_abnormal_muscle_electrophysio0.96025953
116MP0001346_abnormal_lacrimal_gland0.95741524
117MP0001664_abnormal_digestion0.95735635
118MP0003693_abnormal_embryo_hatching0.95528642
119MP0003638_abnormal_response/metabolism_0.95037582
120MP0000003_abnormal_adipose_tissue0.94978667
121MP0004233_abnormal_muscle_weight0.94810651
122MP0003868_abnormal_feces_composition0.94104554
123MP0005409_darkened_coat_color0.91921397
124MP0003633_abnormal_nervous_system0.91183929
125MP0001177_atelectasis0.91070281
126* MP0002752_abnormal_somatic_nervous0.89953880
127MP0003705_abnormal_hypodermis_morpholog0.88428964
128MP0003943_abnormal_hepatobiliary_system0.88152663
129MP0006072_abnormal_retinal_apoptosis0.86744943
130MP0000534_abnormal_ureter_morphology0.85063030
131* MP0002069_abnormal_eating/drinking_beha0.83478562
132MP0001919_abnormal_reproductive_system0.82681376
133MP0000647_abnormal_sebaceous_gland0.81864435
134MP0005379_endocrine/exocrine_gland_phen0.80600246
135MP0000566_synostosis0.79186685
136MP0005499_abnormal_olfactory_system0.78947554
137MP0005394_taste/olfaction_phenotype0.78947554
138* MP0002152_abnormal_brain_morphology0.78383798
139MP0003329_amyloid_beta_deposits0.78212621
140MP0003959_abnormal_lean_body0.78072228
141MP0003136_yellow_coat_color0.77747158
142MP0003937_abnormal_limbs/digits/tail_de0.77278715
143MP0003631_nervous_system_phenotype0.75723509
144MP0002229_neurodegeneration0.74789543
145MP0000678_abnormal_parathyroid_gland0.73425526
146MP0004484_altered_response_of0.72990120
147MP0002697_abnormal_eye_size0.72759379
148* MP0004085_abnormal_heartbeat0.72301190
149MP0003119_abnormal_digestive_system0.71990060
150MP0003121_genomic_imprinting0.70927661
151MP0010771_integument_phenotype0.70894858
152MP0004215_abnormal_myocardial_fiber0.70869110
153MP0005253_abnormal_eye_physiology0.70673066
154MP0008877_abnormal_DNA_methylation0.70648123
155MP0003690_abnormal_glial_cell0.70621546
156MP0003938_abnormal_ear_development0.70262151
157MP0008057_abnormal_DNA_replication0.70102641
158MP0000538_abnormal_urinary_bladder0.69479672
159MP0000751_myopathy0.68549307
160MP0005535_abnormal_body_temperature0.67622244
161* MP0001544_abnormal_cardiovascular_syste0.67421582
162* MP0005385_cardiovascular_system_phenoty0.67421582
163MP0008260_abnormal_autophagy0.67245871
164MP0002896_abnormal_bone_mineralization0.66910508
165MP0000049_abnormal_middle_ear0.66730726
166MP0003186_abnormal_redox_activity0.66168188
167MP0008004_abnormal_stomach_pH0.63531205
168MP0002085_abnormal_embryonic_tissue0.63503948
169MP0004957_abnormal_blastocyst_morpholog0.62938824
170MP0008872_abnormal_physiological_respon0.62656958
171MP0000681_abnormal_thyroid_gland0.62022167
172MP0001879_abnormal_lymphatic_vessel0.61864746
173MP0000013_abnormal_adipose_tissue0.59558416
174MP0002060_abnormal_skin_morphology0.58894373
175* MP0005448_abnormal_energy_balance0.58711545
176* MP0003948_abnormal_gas_homeostasis0.58577834
177MP0002909_abnormal_adrenal_gland0.58035151
178MP0008932_abnormal_embryonic_tissue0.57828602
179MP0005075_abnormal_melanosome_morpholog0.56653936
180MP0010630_abnormal_cardiac_muscle0.55549263
181MP0002163_abnormal_gland_morphology0.54249022
182MP0008874_decreased_physiological_sensi0.54057288
183* MP0002751_abnormal_autonomic_nervous0.53528703
184MP0005084_abnormal_gallbladder_morpholo0.51881671
185MP0004043_abnormal_pH_regulation0.51665436

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.39224059
2Febrile seizures (HP:0002373)5.71654171
3Epileptic encephalopathy (HP:0200134)5.59364223
4Concave nail (HP:0001598)5.43330424
5Focal seizures (HP:0007359)5.01012392
6Atonic seizures (HP:0010819)4.94749833
7Hyperventilation (HP:0002883)4.77633088
8Pseudobulbar signs (HP:0002200)4.67801372
9Oligomenorrhea (HP:0000876)4.66949474
10Myokymia (HP:0002411)3.99614340
11Germ cell neoplasia (HP:0100728)3.79683699
12Sparse lateral eyebrow (HP:0005338)3.78761363
13Dialeptic seizures (HP:0011146)3.68626127
14Absence seizures (HP:0002121)3.62974031
15Progressive cerebellar ataxia (HP:0002073)3.62258088
16Septate vagina (HP:0001153)3.62229353
17Akinesia (HP:0002304)3.50492175
18Broad-based gait (HP:0002136)3.49190840
19Generalized tonic-clonic seizures (HP:0002069)3.43996878
20Protruding tongue (HP:0010808)3.40217137
21Abnormal hair whorl (HP:0010721)3.19187935
22Visual hallucinations (HP:0002367)3.12173945
23Breast carcinoma (HP:0003002)3.09939848
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.02763455
25Absent/shortened dynein arms (HP:0200106)3.02763455
26Renal salt wasting (HP:0000127)2.98578209
27Acanthosis nigricans (HP:0000956)2.88324095
28Drooling (HP:0002307)2.83198951
29Excessive salivation (HP:0003781)2.83198951
30Amblyopia (HP:0000646)2.81647743
31Severe Myopia (HP:0011003)2.81408215
32Abnormality of nail color (HP:0100643)2.79292486
33Gaze-evoked nystagmus (HP:0000640)2.78698679
34Deep philtrum (HP:0002002)2.77141371
35Gait imbalance (HP:0002141)2.76876595
36Hypothermia (HP:0002045)2.72235289
37Microglossia (HP:0000171)2.71061678
38Exostoses (HP:0100777)2.70775864
39Medial flaring of the eyebrow (HP:0010747)2.69134630
40Right ventricular cardiomyopathy (HP:0011663)2.67868502
41Lip pit (HP:0100267)2.60746350
42Fetal akinesia sequence (HP:0001989)2.51424967
43Polyphagia (HP:0002591)2.49666611
44Inability to walk (HP:0002540)2.48308381
45Abnormal ciliary motility (HP:0012262)2.46087492
46Congenital primary aphakia (HP:0007707)2.44777393
47Blue irides (HP:0000635)2.40669156
48Nephrogenic diabetes insipidus (HP:0009806)2.38609907
49Gout (HP:0001997)2.38179352
50Testicular neoplasm (HP:0010788)2.36939874
51Abnormality of the proximal phalanges of the hand (HP:0009834)2.36866138
52Absent speech (HP:0001344)2.32357353
53Septo-optic dysplasia (HP:0100842)2.30101311
54Decreased circulating renin level (HP:0003351)2.28903207
55Lower limb muscle weakness (HP:0007340)2.28789788
56Abnormality of the umbilical cord (HP:0010881)2.28352010
57Abnormal eating behavior (HP:0100738)2.27730388
58Morphological abnormality of the middle ear (HP:0008609)2.27321549
59Enlarged penis (HP:0000040)2.27152999
60Fair hair (HP:0002286)2.23787546
61Sex reversal (HP:0012245)2.21892806
62Abnormal sex determination (HP:0012244)2.21892806
63Epileptiform EEG discharges (HP:0011182)2.21467509
64Generalized hypopigmentation of hair (HP:0011358)2.21066621
65Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.20312891
66Decreased central vision (HP:0007663)2.19910802
67Abnormal respiratory motile cilium morphology (HP:0005938)2.19121023
68Abnormal respiratory epithelium morphology (HP:0012253)2.19121023
69Abnormality of salivation (HP:0100755)2.18473640
70Curly hair (HP:0002212)2.17804438
71Long nose (HP:0003189)2.15178183
72Sleep apnea (HP:0010535)2.14521223
73Abnormal umbilical cord blood vessels (HP:0011403)2.13515909
74Single umbilical artery (HP:0001195)2.13515909
75Abnormality of the fetal cardiovascular system (HP:0010948)2.13515909
76J-shaped sella turcica (HP:0002680)2.12986825
77Poor eye contact (HP:0000817)2.12934077
78Infantile muscular hypotonia (HP:0008947)2.12213407
79Esophageal varix (HP:0002040)2.10325883
80Bradycardia (HP:0001662)2.09102856
81Progressive inability to walk (HP:0002505)2.08553859
82Abnormality of permanent molar morphology (HP:0011071)2.08469640
83Abnormality of the dental root (HP:0006486)2.08469640
84Taurodontia (HP:0000679)2.08469640
85Aplasia/Hypoplasia of the lens (HP:0008063)2.06354830
86Diminished movement (HP:0002374)2.05988982
87Tubulointerstitial nephritis (HP:0001970)2.05829666
88Optic nerve hypoplasia (HP:0000609)2.04562812
89Retinal dysplasia (HP:0007973)2.03844528
90Widely spaced teeth (HP:0000687)2.03588627
91Genital tract atresia (HP:0001827)2.02058965
92Lymphangioma (HP:0100764)2.01601616
93Pterygium (HP:0001059)2.01449439
94Anxiety (HP:0000739)2.00801008
95Hemiparesis (HP:0001269)1.99919550
96Renal dysplasia (HP:0000110)1.99381206
97Abnormality of molar (HP:0011077)1.99239578
98Abnormality of molar morphology (HP:0011070)1.99239578
99Impaired vibration sensation in the lower limbs (HP:0002166)1.98990855
100Growth hormone excess (HP:0000845)1.98833752
101Esotropia (HP:0000565)1.97834576
102Dysdiadochokinesis (HP:0002075)1.97418841
103Abnormal respiratory motile cilium physiology (HP:0012261)1.95391077
104Vaginal atresia (HP:0000148)1.94999608
105Abnormality of binocular vision (HP:0011514)1.93992652
106Diplopia (HP:0000651)1.93992652
107Abnormality of the renal collecting system (HP:0004742)1.93782276
108Narrow nasal bridge (HP:0000446)1.91936370
109Dysmetria (HP:0001310)1.91429890
110Distal lower limb muscle weakness (HP:0009053)1.90180150
111Nephronophthisis (HP:0000090)1.89760792
112Smooth philtrum (HP:0000319)1.89389720
113Congenital sensorineural hearing impairment (HP:0008527)1.88975647
114Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88800267
115Chronic hepatic failure (HP:0100626)1.88692643
116Hyporeflexia of lower limbs (HP:0002600)1.88327186
117Atrioventricular block (HP:0001678)1.87853930
118Impaired social interactions (HP:0000735)1.87561553
119Abnormal social behavior (HP:0012433)1.87561553
120Termporal pattern (HP:0011008)1.87430782
121Insidious onset (HP:0003587)1.87430782
122Abnormality of the gastric mucosa (HP:0004295)1.87054663
123Arterial tortuosity (HP:0005116)1.85882441
124EEG with generalized epileptiform discharges (HP:0011198)1.85786784
125Atelectasis (HP:0100750)1.85524808
126Aplasia/hypoplasia of the humerus (HP:0006507)1.84436979
127Abnormality of the dental pulp (HP:0006479)1.84368361
128Truncal ataxia (HP:0002078)1.82745581
129Genetic anticipation (HP:0003743)1.82189548
130Papillary thyroid carcinoma (HP:0002895)1.82189401
131Hyperthyroidism (HP:0000836)1.81387762
132Clitoromegaly (HP:0000057)1.81117105
133Anal stenosis (HP:0002025)1.81030454
134Aplasia involving bones of the extremities (HP:0009825)1.80070426
135Aplasia involving bones of the upper limbs (HP:0009823)1.80070426
136Aplasia of the phalanges of the hand (HP:0009802)1.80070426
137Absent eyebrow (HP:0002223)1.79841368
138Thickened helices (HP:0000391)1.79487404
139Abnormality of the renal medulla (HP:0100957)1.79006006
140Scanning speech (HP:0002168)1.78279128
141Abnormality of calcium-phosphate metabolism (HP:0100530)1.77367659
142True hermaphroditism (HP:0010459)1.76845920
143Woolly hair (HP:0002224)1.76798854
144Poor coordination (HP:0002370)1.75120459
145Congenital stationary night blindness (HP:0007642)1.74630828
146Bicornuate uterus (HP:0000813)1.74595996
147Osteolytic defects of the hand bones (HP:0009699)1.74014103
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.74014103
149Short humerus (HP:0005792)1.73726380
150Vascular tortuosity (HP:0004948)1.72900202
151Flat capital femoral epiphysis (HP:0003370)1.72691174
152Gastroesophageal reflux (HP:0002020)1.72303661
153Specific learning disability (HP:0001328)1.72256288
154Urinary bladder sphincter dysfunction (HP:0002839)1.71585005
155Hypoplastic labia majora (HP:0000059)1.71078939
156Exotropia (HP:0000577)1.70745942
157Incomplete penetrance (HP:0003829)1.70660355
158Tetraparesis (HP:0002273)1.70240387
159Embryonal renal neoplasm (HP:0011794)1.69968230
160Ovarian neoplasm (HP:0100615)1.69634161
161Limb dystonia (HP:0002451)1.69629228
162Acute lymphatic leukemia (HP:0006721)1.67808822
163Increased circulating renin level (HP:0000848)1.67693326
164Agitation (HP:0000713)1.67656346
165Fused cervical vertebrae (HP:0002949)1.67486080
166Osteomalacia (HP:0002749)1.67230381
167Ankle clonus (HP:0011448)1.66527908
168Hyperaldosteronism (HP:0000859)1.66042549
169Aplasia/Hypoplasia of the tibia (HP:0005772)1.65830775
170Stereotypic behavior (HP:0000733)1.65312039
171Nephroblastoma (Wilms tumor) (HP:0002667)1.64499233
172Neonatal hypoglycemia (HP:0001998)1.63892351
173Pancreatic fibrosis (HP:0100732)1.63563121
174Hypoparathyroidism (HP:0000829)1.62850862
175Unilateral renal agenesis (HP:0000122)1.62301303
176Hypsarrhythmia (HP:0002521)1.62225138
177Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.61945944
178Volvulus (HP:0002580)1.61826145
179Poor suck (HP:0002033)1.61821037
180Macroorchidism (HP:0000053)1.61729288
181Accelerated skeletal maturation (HP:0005616)1.61632726
182Broad nasal tip (HP:0000455)1.61427602
183Hyperactive renin-angiotensin system (HP:0000841)1.59339991
184Choanal stenosis (HP:0000452)1.58493006
185Abnormality of the labia (HP:0000058)1.57963230
186Abnormality of chloride homeostasis (HP:0011422)1.57554401
187Renal hypoplasia (HP:0000089)1.57463087
188Aplasia of the musculature (HP:0100854)1.56593941
189Hypoplastic left heart (HP:0004383)1.55875815
190Abnormality of the labia minora (HP:0012880)1.55401445
191Aplasia/Hypoplasia involving the musculature (HP:0001460)1.53736853
192Long foot (HP:0001833)1.52339879
193Rhabdomyosarcoma (HP:0002859)1.52328837
194Hypertriglyceridemia (HP:0002155)1.51856606
195Spinal cord compression (HP:0002176)1.51109213
196Hyperphosphaturia (HP:0003109)1.50724769
197Insulin-resistant diabetes mellitus (HP:0000831)1.49943324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.87683127
2NTRK34.49210820
3SIK13.92971876
4EPHA43.44370109
5SCYL23.19771561
6TRIM283.18879487
7TESK13.07284839
8SIK32.96740653
9MAP2K72.81604776
10TRIB32.77781205
11EIF2AK12.56380889
12PKN22.51972167
13MAP3K122.30789225
14TNIK2.27739431
15PRPF4B2.23176087
16MAP3K42.21194886
17MARK12.21151819
18EPHA22.19928113
19AKT32.12091597
20RPS6KB22.09213159
21PLK21.93799858
22MAPKAPK31.92713749
23TSSK61.87344039
24NEK11.86441399
25PIK3CA1.84965287
26MINK11.71115916
27LMTK21.70536856
28DAPK21.69386351
29FGFR41.69104807
30MAPK131.68239517
31NTRK21.61519576
32SRPK11.61475498
33DMPK1.56486688
34BCR1.47991558
35BMPR21.45555292
36SIK21.39513522
37MAP2K41.37943825
38DYRK31.31912764
39ADRBK21.31217175
40PDGFRA1.27516521
41OXSR11.26521001
42PAK41.26335505
43INSRR1.23556616
44RIPK41.22794487
45GRK51.21518799
46LATS21.20916220
47DAPK11.20223541
48SGK21.16533093
49PNCK1.16291731
50PBK1.15389787
51CAMK2A1.14508210
52PRKCE1.13313230
53CCNB11.11768860
54GRK71.10651360
55KSR11.06287521
56PRKCG1.06192578
57FGFR21.05818349
58TTK1.05778249
59NME11.05470424
60FES1.05093884
61CDK51.04748889
62NTRK11.04692226
63SGK2231.03983115
64SGK4941.03983115
65CDK191.03031989
66EIF2AK31.02965899
67DYRK1B1.02138890
68CAMK2B0.99623433
69RPS6KB10.98394434
70MAP3K90.98232765
71CAMKK20.97736013
72MAPK40.95817124
73BMPR1B0.95025381
74PAK60.92006057
75RET0.91512551
76PDGFRB0.91497208
77CDK30.90639756
78CAMK10.87170157
79NEK60.86503757
80MUSK0.84346083
81ERBB20.82714177
82BRAF0.81228051
83MARK20.80939075
84STK160.79681707
85ACVR1B0.79673452
86MYLK0.79402592
87GRK60.78245775
88PKN10.75697803
89FER0.75591126
90TNK20.74597429
91ILK0.74420629
92ARAF0.72974960
93WNK30.72935870
94SGK10.69072093
95DYRK1A0.66417295
96ERBB30.66106435
97MKNK10.66063373
98FGFR10.65394223
99CDK60.65352700
100MAPKAPK50.62595468
101CHUK0.62271516
102MAP3K130.62064187
103MTOR0.61807803
104UHMK10.61282292
105ADRBK10.60619002
106IRAK20.59544704
107TIE10.58858583
108DYRK20.58847946
109TYRO30.57764243
110SGK30.57184470
111TAF10.56403227
112MAP2K20.56269248
113PTK2B0.55911388
114ZAK0.55826263
115MKNK20.54786918
116PAK30.54680995
117CAMKK10.54238942
118LIMK10.54093664
119CAMK2D0.53941264
120EEF2K0.53699468
121PHKG10.53692831
122PHKG20.53692831
123EIF2AK20.52908492
124CSNK1E0.50696874
125CDC42BPA0.49907735
126STK240.49251509
127CAMK2G0.49245830
128YES10.49209113
129STK390.47486381
130CDK70.47334106
131TAOK20.46581928
132STK380.46466138
133CSNK1G20.46326478
134DDR20.45905434
135RIPK10.45710290
136CDK180.44454808
137CSNK1D0.44305898
138MAPK90.44055978
139ALK0.43211928
140PRKACA0.41801231
141PRKG10.40689889
142MAP2K60.40481100
143IRAK10.39410604
144MAP3K60.39325506
145PTK20.38796423
146MAPK100.37240675
147CLK10.35978776
148MET0.35658387
149PRKCH0.35432601
150MAPK80.35388495
151PRKAA10.34843506
152FGR0.34515757
153WEE10.34092937
154CAMK1G0.33903247
155CDK150.33602174
156PRKDC0.33212705
157GSK3B0.32252045
158PRKCA0.32079757
159MAP2K10.31605470
160EPHB20.31267994
161FYN0.30889415
162MAPK70.30855927
163CDK140.29897648
164MAPK120.29666983
165CAMK40.29164912

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.61409103
2Synaptic vesicle cycle_Homo sapiens_hsa047213.24570269
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.03483020
4Morphine addiction_Homo sapiens_hsa050322.77708168
5GABAergic synapse_Homo sapiens_hsa047272.68376278
6Circadian entrainment_Homo sapiens_hsa047132.68181642
7Glutamatergic synapse_Homo sapiens_hsa047242.53139303
8Thyroid cancer_Homo sapiens_hsa052162.51332728
9Collecting duct acid secretion_Homo sapiens_hsa049662.44546807
10Taste transduction_Homo sapiens_hsa047422.37778374
11Olfactory transduction_Homo sapiens_hsa047402.35530457
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26919694
13Amphetamine addiction_Homo sapiens_hsa050312.25638450
14Long-term potentiation_Homo sapiens_hsa047202.22897448
15Serotonergic synapse_Homo sapiens_hsa047262.19819696
16* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.17202833
17Caffeine metabolism_Homo sapiens_hsa002322.12884739
18Fatty acid elongation_Homo sapiens_hsa000622.09709827
19Salivary secretion_Homo sapiens_hsa049702.03630566
20Pyruvate metabolism_Homo sapiens_hsa006202.01600854
21Phenylalanine metabolism_Homo sapiens_hsa003602.00357788
22AMPK signaling pathway_Homo sapiens_hsa041521.96183599
23Insulin secretion_Homo sapiens_hsa049111.94741110
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89342892
25PPAR signaling pathway_Homo sapiens_hsa033201.88720909
26Dopaminergic synapse_Homo sapiens_hsa047281.88053700
27Histidine metabolism_Homo sapiens_hsa003401.83735813
28Calcium signaling pathway_Homo sapiens_hsa040201.83632822
29Propanoate metabolism_Homo sapiens_hsa006401.80070177
30Long-term depression_Homo sapiens_hsa047301.78727707
31Cholinergic synapse_Homo sapiens_hsa047251.77835327
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71673060
33Phototransduction_Homo sapiens_hsa047441.67693150
34Renin secretion_Homo sapiens_hsa049241.66789918
35beta-Alanine metabolism_Homo sapiens_hsa004101.58720476
36Oxytocin signaling pathway_Homo sapiens_hsa049211.52907550
37Cocaine addiction_Homo sapiens_hsa050301.52493478
38Gastric acid secretion_Homo sapiens_hsa049711.49345119
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.48998319
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44476225
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42455342
42Axon guidance_Homo sapiens_hsa043601.42394885
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41355922
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40746371
45Endometrial cancer_Homo sapiens_hsa052131.39275873
46Vibrio cholerae infection_Homo sapiens_hsa051101.37226743
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36883882
48Glycerolipid metabolism_Homo sapiens_hsa005611.34635430
49Tight junction_Homo sapiens_hsa045301.31198308
50Adherens junction_Homo sapiens_hsa045201.29162308
51Fatty acid degradation_Homo sapiens_hsa000711.28159306
52Insulin signaling pathway_Homo sapiens_hsa049101.24964020
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24505090
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21427474
55* cAMP signaling pathway_Homo sapiens_hsa040241.19446620
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19253220
57Tyrosine metabolism_Homo sapiens_hsa003501.17492047
58Hippo signaling pathway_Homo sapiens_hsa043901.17262641
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16622907
60Oxidative phosphorylation_Homo sapiens_hsa001901.15563735
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.13794263
62Vitamin B6 metabolism_Homo sapiens_hsa007501.12531122
63GnRH signaling pathway_Homo sapiens_hsa049121.09193295
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08044298
65Rheumatoid arthritis_Homo sapiens_hsa053231.06503411
66Cardiac muscle contraction_Homo sapiens_hsa042601.03206943
67Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02386572
68Gap junction_Homo sapiens_hsa045401.01753478
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98387104
70Insulin resistance_Homo sapiens_hsa049310.97543855
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97289246
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94881394
73Melanogenesis_Homo sapiens_hsa049160.94209756
74Type II diabetes mellitus_Homo sapiens_hsa049300.92147352
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92125549
76Fatty acid metabolism_Homo sapiens_hsa012120.92069933
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91160173
78TGF-beta signaling pathway_Homo sapiens_hsa043500.90287658
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90161851
80Alzheimers disease_Homo sapiens_hsa050100.88274626
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.87695522
82Proteoglycans in cancer_Homo sapiens_hsa052050.87477099
83Type I diabetes mellitus_Homo sapiens_hsa049400.85743685
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85569770
85mRNA surveillance pathway_Homo sapiens_hsa030150.83715259
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82318054
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81839990
88ErbB signaling pathway_Homo sapiens_hsa040120.80535772
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79782818
90Pancreatic secretion_Homo sapiens_hsa049720.78678752
91Dilated cardiomyopathy_Homo sapiens_hsa054140.76503221
92Prostate cancer_Homo sapiens_hsa052150.75484182
93Circadian rhythm_Homo sapiens_hsa047100.73990272
94Ras signaling pathway_Homo sapiens_hsa040140.73739432
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.73462436
96Estrogen signaling pathway_Homo sapiens_hsa049150.72705378
97Lysine degradation_Homo sapiens_hsa003100.71655994
98MAPK signaling pathway_Homo sapiens_hsa040100.70433457
99Tryptophan metabolism_Homo sapiens_hsa003800.67525099
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65182508
101Glioma_Homo sapiens_hsa052140.64856117
102Steroid biosynthesis_Homo sapiens_hsa001000.63760875
103Ovarian steroidogenesis_Homo sapiens_hsa049130.61765418
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58033081
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57855406
106MicroRNAs in cancer_Homo sapiens_hsa052060.57090686
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.56715786
108Choline metabolism in cancer_Homo sapiens_hsa052310.56689196
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56253709
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56164811
111Basal cell carcinoma_Homo sapiens_hsa052170.55965015
112Phagosome_Homo sapiens_hsa041450.55052756
113Inositol phosphate metabolism_Homo sapiens_hsa005620.54838107
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53643170
115Melanoma_Homo sapiens_hsa052180.52796248
116Prolactin signaling pathway_Homo sapiens_hsa049170.52608808
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51884204
118Wnt signaling pathway_Homo sapiens_hsa043100.51591627
119Sphingolipid metabolism_Homo sapiens_hsa006000.51579190
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51075599
121Parkinsons disease_Homo sapiens_hsa050120.50792670
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49792022
123Basal transcription factors_Homo sapiens_hsa030220.49736728
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49601275
125Rap1 signaling pathway_Homo sapiens_hsa040150.49578422
126Retinol metabolism_Homo sapiens_hsa008300.49406857
127RNA transport_Homo sapiens_hsa030130.49391056
128mTOR signaling pathway_Homo sapiens_hsa041500.45253701
129African trypanosomiasis_Homo sapiens_hsa051430.45112663
130Huntingtons disease_Homo sapiens_hsa050160.44685181
131Butanoate metabolism_Homo sapiens_hsa006500.43912355
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43711743
133Spliceosome_Homo sapiens_hsa030400.43166871
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43027914
135Vitamin digestion and absorption_Homo sapiens_hsa049770.42830780
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.42569970
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42563497
138* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41556009
139Thyroid hormone synthesis_Homo sapiens_hsa049180.40894265
140Carbon metabolism_Homo sapiens_hsa012000.39699248
141Renal cell carcinoma_Homo sapiens_hsa052110.39601384
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32881034
143Dorso-ventral axis formation_Homo sapiens_hsa043200.30725770
144Alcoholism_Homo sapiens_hsa050340.30045635
145Autoimmune thyroid disease_Homo sapiens_hsa053200.29034085
146Oocyte meiosis_Homo sapiens_hsa041140.28485339
147Regulation of autophagy_Homo sapiens_hsa041400.27223940
148Glucagon signaling pathway_Homo sapiens_hsa049220.26598897
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.26545481
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24517482
151Ether lipid metabolism_Homo sapiens_hsa005650.24505083
152Chemokine signaling pathway_Homo sapiens_hsa040620.23850534
153Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18903106
154Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18739168
155Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16151918
156Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16114029
157Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15832563
158Neurotrophin signaling pathway_Homo sapiens_hsa047220.13293933
159Mineral absorption_Homo sapiens_hsa049780.12503801

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