NPY5R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.85392344
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.79218314
3neuron cell-cell adhesion (GO:0007158)5.67353244
4synaptic vesicle exocytosis (GO:0016079)5.58344929
5tachykinin receptor signaling pathway (GO:0007217)5.57958018
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.53081548
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.43063352
8regulation of glutamate receptor signaling pathway (GO:1900449)5.23807753
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22422472
10glutamate secretion (GO:0014047)5.14994890
11presynaptic membrane assembly (GO:0097105)5.14513297
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.05630879
13presynaptic membrane organization (GO:0097090)4.92740962
14protein localization to synapse (GO:0035418)4.90945616
15regulation of synaptic vesicle exocytosis (GO:2000300)4.81434097
16neurotransmitter-gated ion channel clustering (GO:0072578)4.75445429
17DNA double-strand break processing (GO:0000729)4.63633661
18gamma-aminobutyric acid signaling pathway (GO:0007214)4.53164056
19postsynaptic membrane organization (GO:0001941)4.50108348
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.48432071
21long-term synaptic potentiation (GO:0060291)4.47487436
22positive regulation of synapse maturation (GO:0090129)4.45973384
23locomotory exploration behavior (GO:0035641)4.39022375
24regulation of synaptic vesicle transport (GO:1902803)4.33999372
25neuron-neuron synaptic transmission (GO:0007270)4.32896269
26response to histamine (GO:0034776)4.27639397
27neurotransmitter secretion (GO:0007269)4.21057582
28glutamate receptor signaling pathway (GO:0007215)4.16927951
29synaptic transmission, glutamatergic (GO:0035249)4.11825539
30* regulation of glutamate secretion (GO:0014048)4.08587740
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03366868
32righting reflex (GO:0060013)4.03093249
33neuronal action potential propagation (GO:0019227)4.03074623
34otic vesicle formation (GO:0030916)3.93259667
35synaptic vesicle maturation (GO:0016188)3.91938706
36cerebellar granule cell differentiation (GO:0021707)3.91116143
37calcium-mediated signaling using intracellular calcium source (GO:0035584)3.85184999
38startle response (GO:0001964)3.84689211
39positive regulation of mitochondrial fission (GO:0090141)3.84600539
40energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.81301943
41ATP hydrolysis coupled proton transport (GO:0015991)3.81301943
42regulation of postsynaptic membrane potential (GO:0060078)3.79624504
43transferrin transport (GO:0033572)3.78596862
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.78306344
45regulation of synapse maturation (GO:0090128)3.78178189
46cell migration in hindbrain (GO:0021535)3.74922366
47negative regulation of appetite (GO:0032099)3.73863724
48negative regulation of response to food (GO:0032096)3.73863724
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.72516992
50fatty acid elongation (GO:0030497)3.72483980
51positive regulation of synapse assembly (GO:0051965)3.71645156
52behavioral response to cocaine (GO:0048148)3.71404849
53neuron recognition (GO:0008038)3.68813673
54regulation of synaptic plasticity (GO:0048167)3.67930315
55positive regulation of neurotransmitter secretion (GO:0001956)3.63214150
56* negative regulation of synaptic transmission, GABAergic (GO:0032229)3.60650046
57exploration behavior (GO:0035640)3.59952988
58regulation of neuronal synaptic plasticity (GO:0048168)3.58791799
59positive regulation of membrane potential (GO:0045838)3.54526541
60pyrimidine nucleobase catabolic process (GO:0006208)3.53233565
61ferric iron transport (GO:0015682)3.52456806
62trivalent inorganic cation transport (GO:0072512)3.52456806
63serotonin metabolic process (GO:0042428)3.52203872
64neurotransmitter transport (GO:0006836)3.50443078
65urinary tract smooth muscle contraction (GO:0014848)3.49936029
66negative regulation of neurotransmitter transport (GO:0051589)3.47909368
67somite development (GO:0061053)3.42907044
68polyol transport (GO:0015791)3.42489787
69regulation of neurotransmitter secretion (GO:0046928)3.42414196
70cellular response to leptin stimulus (GO:0044320)3.40506377
71response to auditory stimulus (GO:0010996)3.39298679
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.39215795
73synaptic vesicle endocytosis (GO:0048488)3.38302019
74positive regulation of neurotransmitter transport (GO:0051590)3.35891186
75long-term memory (GO:0007616)3.35692097
76triglyceride catabolic process (GO:0019433)3.34723927
77regulation of vesicle fusion (GO:0031338)3.31479512
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24532772
79long term synaptic depression (GO:0060292)3.23350601
80response to pheromone (GO:0019236)3.23047498
81axonal fasciculation (GO:0007413)3.20666399
82C4-dicarboxylate transport (GO:0015740)3.19734954
83negative regulation of dendrite morphogenesis (GO:0050774)3.19366493
84regulation of female receptivity (GO:0045924)3.19170231
85paraxial mesoderm development (GO:0048339)3.18882825
86positive regulation of synaptic transmission (GO:0050806)3.18441072
87regulation of neurotransmitter levels (GO:0001505)3.18006515
88behavioral fear response (GO:0001662)3.17654791
89behavioral defense response (GO:0002209)3.17654791
90regulation of dendritic spine morphogenesis (GO:0061001)3.17226773
91learning (GO:0007612)3.17132791
92regulation of neurotransmitter transport (GO:0051588)3.15818718
93negative regulation of cytosolic calcium ion concentration (GO:0051481)3.15556775
94female mating behavior (GO:0060180)3.13749658
95positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12229460
96fear response (GO:0042596)3.11299099
97* negative regulation of amino acid transport (GO:0051956)3.11221372
98auditory behavior (GO:0031223)3.10533328
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09008878
100synaptic transmission, dopaminergic (GO:0001963)3.08698709
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08352633
102acylglycerol catabolic process (GO:0046464)3.08246544
103neutral lipid catabolic process (GO:0046461)3.08246544
104membrane depolarization (GO:0051899)3.08181392
105valine metabolic process (GO:0006573)3.07762439
106membrane repolarization (GO:0086009)3.07497983
107regulation of cAMP-dependent protein kinase activity (GO:2000479)3.07113559
108regulation of synapse structural plasticity (GO:0051823)3.05499358
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05116498
110detection of calcium ion (GO:0005513)3.04547087
111primary amino compound metabolic process (GO:1901160)3.03922120
112serotonin receptor signaling pathway (GO:0007210)3.02588099
113DNA damage response, detection of DNA damage (GO:0042769)2.99926341
114* regulation of synaptic transmission (GO:0050804)2.99816486
115regulation of protein kinase A signaling (GO:0010738)2.99293627
116* negative regulation of amine transport (GO:0051953)2.97069215
117mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96701573
118striatum development (GO:0021756)2.96677905
119response to dietary excess (GO:0002021)2.96262945
120dendritic spine morphogenesis (GO:0060997)2.96121828
121* synaptic transmission (GO:0007268)2.95377119
122mechanosensory behavior (GO:0007638)2.94274375
123synaptic vesicle transport (GO:0048489)2.93840521
124establishment of synaptic vesicle localization (GO:0097480)2.93840521
125regulation of synapse assembly (GO:0051963)2.93571211
126synapse assembly (GO:0007416)2.93331794
127regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93139231
128proline transport (GO:0015824)2.91888148
129G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91451508
130neuronal ion channel clustering (GO:0045161)2.88342125
131potassium ion export (GO:0071435)2.87032511
132fatty acid homeostasis (GO:0055089)2.86568336
133protein localization to cilium (GO:0061512)2.86380911
134vascular smooth muscle contraction (GO:0014829)2.85336912
135transmission of nerve impulse (GO:0019226)2.78301977
136nerve growth factor signaling pathway (GO:0038180)2.77606882
137response to leptin (GO:0044321)2.75808376
138brain morphogenesis (GO:0048854)2.75283129
139cell wall macromolecule metabolic process (GO:0044036)2.74635749
140peroxisome fission (GO:0016559)2.73895446
141regulation of sequestering of triglyceride (GO:0010889)2.73525764
142retinal rod cell development (GO:0046548)2.73131738
143adrenergic receptor signaling pathway (GO:0071875)2.72721699
144positive regulation of male gonad development (GO:2000020)2.71871664
145limb bud formation (GO:0060174)2.71786272
146keratinocyte development (GO:0003334)2.71718092
147regulation of protein glycosylation (GO:0060049)2.68134929
148regulation of mitochondrial fission (GO:0090140)2.67668519
149nucleobase catabolic process (GO:0046113)2.64523480
150membrane repolarization during action potential (GO:0086011)2.62434862
151alpha-linolenic acid metabolic process (GO:0036109)2.60615846
152retinal ganglion cell axon guidance (GO:0031290)2.59704318
153positive regulation of insulin receptor signaling pathway (GO:0046628)2.59160979
154regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58234755
155regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.57684526
156adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.57648025
157regulation of helicase activity (GO:0051095)2.55168854
158parturition (GO:0007567)2.54375250
159adult feeding behavior (GO:0008343)2.53888493
160platelet dense granule organization (GO:0060155)2.52634771
161glucosamine-containing compound catabolic process (GO:1901072)2.49979353
162lipid particle organization (GO:0034389)2.48533382
163melanosome transport (GO:0032402)2.45710466
164cell communication involved in cardiac conduction (GO:0086065)2.45133000
165retina vasculature morphogenesis in camera-type eye (GO:0061299)2.44762593
166cGMP-mediated signaling (GO:0019934)2.43191051
167neuronal action potential (GO:0019228)2.41888291
168nonmotile primary cilium assembly (GO:0035058)2.41788198
169low-density lipoprotein particle clearance (GO:0034383)2.39553928
170dendrite morphogenesis (GO:0048813)2.37050844
171hindbrain development (GO:0030902)2.36683993
172cellular response to BMP stimulus (GO:0071773)2.36620644
173response to BMP (GO:0071772)2.36620644
174regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.36053020
175cardiac muscle cell action potential (GO:0086001)2.36044238
176regulation of response to food (GO:0032095)2.34986067
177ventricular cardiac muscle cell action potential (GO:0086005)2.33541148
178kidney morphogenesis (GO:0060993)2.32949369
179establishment of melanosome localization (GO:0032401)2.31909917
180glycerol metabolic process (GO:0006071)2.31879842
181reflex (GO:0060004)2.31813764
182negative regulation of DNA-dependent DNA replication (GO:2000104)2.31583751
183action potential (GO:0001508)2.31451952
184male meiosis I (GO:0007141)2.31378767
185regulation of acyl-CoA biosynthetic process (GO:0050812)2.31221541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59754805
2GBX2_23144817_ChIP-Seq_PC3_Human4.65341734
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25198753
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08597435
5TAF15_26573619_Chip-Seq_HEK293_Human3.02869143
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99465029
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.76999608
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.69586528
9REST_21632747_ChIP-Seq_MESCs_Mouse2.64049105
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61155043
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54184448
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54184448
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53296035
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52497768
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49497936
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.48617565
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.41917668
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.40232298
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38754599
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38663266
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35225650
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.33249329
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.29882353
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27910725
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24117859
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.09858142
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09467894
28VDR_22108803_ChIP-Seq_LS180_Human2.03070719
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.99252018
30P300_19829295_ChIP-Seq_ESCs_Human1.99154049
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.98958159
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98420862
33SMAD4_21799915_ChIP-Seq_A2780_Human1.90587497
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.85483069
35FUS_26573619_Chip-Seq_HEK293_Human1.82384367
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81487616
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73165862
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72946723
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.71924183
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66336095
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.66067015
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65970425
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65445518
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63492593
45DROSHA_22980978_ChIP-Seq_HELA_Human1.59564860
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54661834
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53500081
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.51369552
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50811706
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50373321
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.49891384
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.49067583
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.46537026
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46157346
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45620254
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45418718
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.43455135
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43201742
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43201742
60AR_25329375_ChIP-Seq_VCAP_Human1.42719010
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42463462
62AR_21572438_ChIP-Seq_LNCaP_Human1.41308627
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40733888
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.35756032
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.35720750
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35272340
67RNF2_27304074_Chip-Seq_NSC_Mouse1.31811142
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31756151
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31681478
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30226731
71ZNF274_21170338_ChIP-Seq_K562_Hela1.30067046
72JUN_21703547_ChIP-Seq_K562_Human1.29548287
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28860850
74ER_23166858_ChIP-Seq_MCF-7_Human1.28130961
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.27616946
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27266399
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26017825
78CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25404050
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22824882
80STAT3_23295773_ChIP-Seq_U87_Human1.20906020
81TCF4_22108803_ChIP-Seq_LS180_Human1.17986757
82TCF4_23295773_ChIP-Seq_U87_Human1.17215683
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15881303
84* PRDM14_20953172_ChIP-Seq_ESCs_Human1.15736972
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15160574
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.14705110
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14583879
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13785060
89* TAL1_26923725_Chip-Seq_HPCs_Mouse1.12081032
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11502170
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11439240
92TP53_18474530_ChIP-ChIP_U2OS_Human1.11050343
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09695743
94RUNX2_22187159_ChIP-Seq_PCA_Human1.08703881
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08697951
96IGF1R_20145208_ChIP-Seq_DFB_Human1.08654619
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.07423565
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06624382
99* ARNT_22903824_ChIP-Seq_MCF-7_Human1.05483043
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04649744
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04645801
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.03727451
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03717288
104AHR_22903824_ChIP-Seq_MCF-7_Human1.02477789
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02079086
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00979135
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00025810
108AR_19668381_ChIP-Seq_PC3_Human0.99550714
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99448467
110EWS_26573619_Chip-Seq_HEK293_Human0.99326115
111BCAT_22108803_ChIP-Seq_LS180_Human0.99290509
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99219702
113SOX9_26525672_Chip-Seq_HEART_Mouse0.99004701
114* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97862803
115SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97222413
116KDM2B_26808549_Chip-Seq_REH_Human0.95821034
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94824144
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93739694
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93244393
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92116113
121TP53_16413492_ChIP-PET_HCT116_Human0.91768710
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90866715
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90784778
124ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89950689
125E2F1_18555785_Chip-Seq_ESCs_Mouse0.89168209
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.88416024
127CBP_20019798_ChIP-Seq_JUKART_Human0.88229297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.94700733
2MP0004859_abnormal_synaptic_plasticity5.39256395
3MP0005670_abnormal_white_adipose4.63114414
4MP0003635_abnormal_synaptic_transmissio3.98276019
5MP0009745_abnormal_behavioral_response3.66004636
6MP0001968_abnormal_touch/_nociception3.59360674
7MP0002822_catalepsy3.50571983
8MP0002064_seizures3.25260422
9MP0002063_abnormal_learning/memory/cond3.25101883
10MP0009046_muscle_twitch3.16188216
11MP0004270_analgesia3.01634012
12MP0002572_abnormal_emotion/affect_behav2.92450080
13MP0002736_abnormal_nociception_after2.80456420
14MP0005666_abnormal_adipose_tissue2.80063822
15MP0002272_abnormal_nervous_system2.56780293
16MP0003136_yellow_coat_color2.53906880
17MP0001501_abnormal_sleep_pattern2.48996724
18MP0002735_abnormal_chemical_nociception2.42373806
19MP0002837_dystrophic_cardiac_calcinosis2.36290011
20MP0003890_abnormal_embryonic-extraembry2.34708963
21MP0001188_hyperpigmentation2.34261620
22MP0001440_abnormal_grooming_behavior2.28392379
23MP0004185_abnormal_adipocyte_glucose2.26242152
24MP0002734_abnormal_mechanical_nocicepti2.25740865
25MP0001486_abnormal_startle_reflex2.18448040
26MP0003122_maternal_imprinting2.13873915
27MP0005248_abnormal_Harderian_gland2.12442844
28MP0006276_abnormal_autonomic_nervous2.11683011
29MP0002067_abnormal_sensory_capabilities2.10977909
30MP0009780_abnormal_chondrocyte_physiolo2.05412372
31MP0003787_abnormal_imprinting1.98383325
32MP0001905_abnormal_dopamine_level1.93689351
33MP0002733_abnormal_thermal_nociception1.91641224
34MP0004924_abnormal_behavior1.84333613
35MP0005386_behavior/neurological_phenoty1.84333613
36MP0004130_abnormal_muscle_cell1.81270866
37MP0001529_abnormal_vocalization1.81183323
38MP0003879_abnormal_hair_cell1.75947189
39MP0001970_abnormal_pain_threshold1.75479307
40MP0002557_abnormal_social/conspecific_i1.69785125
41MP0008789_abnormal_olfactory_epithelium1.69431357
42MP0002184_abnormal_innervation1.69018224
43MP0001984_abnormal_olfaction1.68094154
44MP0000537_abnormal_urethra_morphology1.67003010
45MP0005423_abnormal_somatic_nervous1.65465329
46MP0004084_abnormal_cardiac_muscle1.65352861
47MP0005646_abnormal_pituitary_gland1.65147089
48MP0003329_amyloid_beta_deposits1.63116641
49MP0002653_abnormal_ependyma_morphology1.56946551
50MP0000778_abnormal_nervous_system1.53702103
51MP0005647_abnormal_sex_gland1.53547340
52MP0005645_abnormal_hypothalamus_physiol1.53379630
53MP0003011_delayed_dark_adaptation1.53301125
54MP0005375_adipose_tissue_phenotype1.52986979
55MP0003137_abnormal_impulse_conducting1.52866144
56MP0002876_abnormal_thyroid_physiology1.45232246
57MP0005167_abnormal_blood-brain_barrier1.43385016
58MP0002638_abnormal_pupillary_reflex1.42374373
59MP0002751_abnormal_autonomic_nervous1.41806207
60MP0004811_abnormal_neuron_physiology1.38952110
61MP0000013_abnormal_adipose_tissue1.38197404
62MP0002909_abnormal_adrenal_gland1.37637038
63MP0008569_lethality_at_weaning1.35868748
64MP0001502_abnormal_circadian_rhythm1.35686257
65MP0009672_abnormal_birth_weight1.35641481
66MP0003119_abnormal_digestive_system1.34830828
67MP0004142_abnormal_muscle_tone1.33827678
68MP0002066_abnormal_motor_capabilities/c1.32639290
69MP0010386_abnormal_urinary_bladder1.28099862
70MP0006292_abnormal_olfactory_placode1.22585507
71MP0003959_abnormal_lean_body1.22297599
72MP0002971_abnormal_brown_adipose1.19283708
73MP0003633_abnormal_nervous_system1.18136057
74MP0000955_abnormal_spinal_cord1.16387501
75MP0002882_abnormal_neuron_morphology1.16366994
76MP0003941_abnormal_skin_development1.16129899
77MP0002254_reproductive_system_inflammat1.15195660
78MP0005171_absent_coat_pigmentation1.11980622
79MP0001661_extended_life_span1.10024957
80MP0005503_abnormal_tendon_morphology1.07273571
81* MP0005334_abnormal_fat_pad1.06870938
82MP0003221_abnormal_cardiomyocyte_apopto1.05052639
83MP0003631_nervous_system_phenotype1.04058659
84MP0000751_myopathy1.03155405
85MP0001346_abnormal_lacrimal_gland1.02470665
86MP0004742_abnormal_vestibular_system1.01180206
87MP0004858_abnormal_nervous_system1.00419083
88MP0008872_abnormal_physiological_respon0.97762028
89MP0005253_abnormal_eye_physiology0.97167398
90MP0009703_decreased_birth_body0.96966714
91MP0003937_abnormal_limbs/digits/tail_de0.96890974
92MP0003121_genomic_imprinting0.96527597
93MP0005409_darkened_coat_color0.94155638
94MP0002160_abnormal_reproductive_system0.94087045
95MP0006138_congestive_heart_failure0.92746024
96MP0008874_decreased_physiological_sensi0.92321840
97MP0005535_abnormal_body_temperature0.90390294
98MP0001764_abnormal_homeostasis0.90091839
99MP0001963_abnormal_hearing_physiology0.89636793
100* MP0002069_abnormal_eating/drinking_beha0.89388727
101MP0000516_abnormal_urinary_system0.88994125
102MP0005367_renal/urinary_system_phenotyp0.88994125
103MP0005620_abnormal_muscle_contractility0.88611012
104MP0005551_abnormal_eye_electrophysiolog0.88339597
105MP0008877_abnormal_DNA_methylation0.87802836
106MP0004484_altered_response_of0.86438270
107MP0002152_abnormal_brain_morphology0.85686917
108MP0001879_abnormal_lymphatic_vessel0.84506225
109MP0004147_increased_porphyrin_level0.83952165
110MP0005195_abnormal_posterior_eye0.83910870
111MP0004085_abnormal_heartbeat0.83222986
112MP0003718_maternal_effect0.82404749
113MP0002229_neurodegeneration0.82192002
114MP0001664_abnormal_digestion0.81075517
115MP0000427_abnormal_hair_cycle0.80622354
116MP0006072_abnormal_retinal_apoptosis0.80089385
117MP0003315_abnormal_perineum_morphology0.80079678
118MP0004885_abnormal_endolymph0.79760076
119MP0003861_abnormal_nervous_system0.78131342
120MP0004145_abnormal_muscle_electrophysio0.77407892
121MP0002697_abnormal_eye_size0.76801597
122MP0000604_amyloidosis0.76229736
123MP0003183_abnormal_peptide_metabolism0.75383553
124MP0003123_paternal_imprinting0.75207733
125MP0004215_abnormal_myocardial_fiber0.73600410
126MP0000631_abnormal_neuroendocrine_gland0.71844725
127MP0001177_atelectasis0.67888777
128MP0003632_abnormal_nervous_system0.67310219
129MP0005379_endocrine/exocrine_gland_phen0.64205663
130MP0002752_abnormal_somatic_nervous0.63454258
131MP0001943_abnormal_respiration0.60475026
132MP0008004_abnormal_stomach_pH0.59379219
133MP0004233_abnormal_muscle_weight0.58877125
134MP0005623_abnormal_meninges_morphology0.56972533
135MP0002163_abnormal_gland_morphology0.56594320
136MP0001485_abnormal_pinna_reflex0.56558322
137MP0002090_abnormal_vision0.56540899
138MP0004036_abnormal_muscle_relaxation0.55744493
139MP0000026_abnormal_inner_ear0.54563659
140MP0005187_abnormal_penis_morphology0.53660414
141MP0010234_abnormal_vibrissa_follicle0.49345479
142MP0002082_postnatal_lethality0.48861383
143MP0010770_preweaning_lethality0.48861383
144MP0001765_abnormal_ion_homeostasis0.48456945
145MP0003283_abnormal_digestive_organ0.47876409
146MP0003646_muscle_fatigue0.47870767
147* MP0005448_abnormal_energy_balance0.46660362
148MP0005499_abnormal_olfactory_system0.45886151
149MP0005394_taste/olfaction_phenotype0.45886151

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.43812966
2Hyperventilation (HP:0002883)6.36704450
3Epileptic encephalopathy (HP:0200134)6.35186371
4Atonic seizures (HP:0010819)5.79253506
5Focal seizures (HP:0007359)5.49395730
6Febrile seizures (HP:0002373)5.02450919
7Myokymia (HP:0002411)4.79463995
8Absence seizures (HP:0002121)4.71384664
9Dialeptic seizures (HP:0011146)4.65301204
10Visual hallucinations (HP:0002367)4.31378601
11Broad-based gait (HP:0002136)4.09661751
12Generalized tonic-clonic seizures (HP:0002069)3.88421577
13Amblyopia (HP:0000646)3.65664095
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48712560
15Colon cancer (HP:0003003)3.45991913
16Chromsome breakage (HP:0040012)3.37085211
17Intestinal atresia (HP:0011100)3.26439100
18Progressive inability to walk (HP:0002505)3.19989617
19Progressive cerebellar ataxia (HP:0002073)3.19010848
20Abnormal eating behavior (HP:0100738)3.18278266
21Protruding tongue (HP:0010808)3.13504321
22Excessive salivation (HP:0003781)3.12889463
23Drooling (HP:0002307)3.12889463
24Congenital primary aphakia (HP:0007707)3.09041325
25Epileptiform EEG discharges (HP:0011182)3.07696284
26Inability to walk (HP:0002540)3.07109715
27Poor eye contact (HP:0000817)3.04818622
28Acute necrotizing encephalopathy (HP:0006965)3.00714073
29Dysdiadochokinesis (HP:0002075)2.95828205
30Polyphagia (HP:0002591)2.92290346
31Anxiety (HP:0000739)2.89226974
32Thickened helices (HP:0000391)2.88927651
33Medial flaring of the eyebrow (HP:0010747)2.88739969
34Vaginal atresia (HP:0000148)2.88133017
35Genital tract atresia (HP:0001827)2.83866468
36Nephrogenic diabetes insipidus (HP:0009806)2.83509856
37Abnormal hair whorl (HP:0010721)2.82848971
38Sex reversal (HP:0012245)2.81447719
39Abnormal sex determination (HP:0012244)2.81447719
40Abnormal mitochondria in muscle tissue (HP:0008316)2.81318386
41Renal cortical cysts (HP:0000803)2.76332710
42Gaze-evoked nystagmus (HP:0000640)2.73923917
43Truncal ataxia (HP:0002078)2.73778818
44Progressive macrocephaly (HP:0004481)2.71181333
45Abnormal social behavior (HP:0012433)2.66948442
46Impaired social interactions (HP:0000735)2.66948442
47Vitreoretinal degeneration (HP:0000655)2.64198145
48Poor coordination (HP:0002370)2.63288742
49Hyperthyroidism (HP:0000836)2.63091782
50Embryonal renal neoplasm (HP:0011794)2.62635149
51Nephroblastoma (Wilms tumor) (HP:0002667)2.61490538
52Pheochromocytoma (HP:0002666)2.60209613
53EEG with generalized epileptiform discharges (HP:0011198)2.59351018
54True hermaphroditism (HP:0010459)2.55417043
55Cerebral inclusion bodies (HP:0100314)2.54561572
56Mitochondrial inheritance (HP:0001427)2.48977658
57Neuroendocrine neoplasm (HP:0100634)2.48391552
58Septo-optic dysplasia (HP:0100842)2.48269634
59Ankle clonus (HP:0011448)2.44556940
60Hepatoblastoma (HP:0002884)2.43607745
61Poor suck (HP:0002033)2.43524739
62Dysmetria (HP:0001310)2.42460378
63Supranuclear gaze palsy (HP:0000605)2.42244411
64Absent speech (HP:0001344)2.39242062
65Acute encephalopathy (HP:0006846)2.38864720
66Urinary urgency (HP:0000012)2.35687388
67Scrotal hypoplasia (HP:0000046)2.33429070
68Hypsarrhythmia (HP:0002521)2.32518008
69Depression (HP:0000716)2.32161401
70Insidious onset (HP:0003587)2.30974655
71Termporal pattern (HP:0011008)2.30974655
72Failure to thrive in infancy (HP:0001531)2.29571100
73Abnormality of the labia minora (HP:0012880)2.29209026
74Absent eyebrow (HP:0002223)2.28910596
75Bradykinesia (HP:0002067)2.27933503
76Impaired vibration sensation in the lower limbs (HP:0002166)2.27695880
77Blue irides (HP:0000635)2.27582658
78Sensory axonal neuropathy (HP:0003390)2.27199565
79Status epilepticus (HP:0002133)2.25024725
80Rectal fistula (HP:0100590)2.23521675
81Rectovaginal fistula (HP:0000143)2.23521675
82Oligomenorrhea (HP:0000876)2.23311972
83Optic nerve hypoplasia (HP:0000609)2.23121542
84Abnormality of the ileum (HP:0001549)2.21740888
85Abnormal ciliary motility (HP:0012262)2.21185744
86Retinal atrophy (HP:0001105)2.21021512
87Limb dystonia (HP:0002451)2.20130633
88Abnormality of the left ventricular outflow tract (HP:0011103)2.17179207
89Subaortic stenosis (HP:0001682)2.17179207
90Generalized myoclonic seizures (HP:0002123)2.15868133
91Hypoglycemic coma (HP:0001325)2.15595442
92Retinal dysplasia (HP:0007973)2.14914530
93Astigmatism (HP:0000483)2.14803544
94Abolished electroretinogram (ERG) (HP:0000550)2.14602126
95Broad foot (HP:0001769)2.14430231
96Abnormality of salivation (HP:0100755)2.14098602
97Meckel diverticulum (HP:0002245)2.13722690
98Increased CSF lactate (HP:0002490)2.13017006
99Action tremor (HP:0002345)2.12357354
100Esotropia (HP:0000565)2.11957791
101Prolonged QT interval (HP:0001657)2.11870971
102Delusions (HP:0000746)2.11792707
103Rimmed vacuoles (HP:0003805)2.10889647
104Syncope (HP:0001279)2.09118601
105Postural instability (HP:0002172)2.08425308
106Medulloblastoma (HP:0002885)2.07967586
107Abnormal gallbladder physiology (HP:0012438)2.06509584
108Cholecystitis (HP:0001082)2.06509584
109Stereotypic behavior (HP:0000733)2.06325292
110Psychosis (HP:0000709)2.04628950
111Aplasia/Hypoplasia of the uvula (HP:0010293)2.04363108
112Hepatocellular necrosis (HP:0001404)2.03099538
113Hypoventilation (HP:0002791)2.02683189
114Narrow nasal bridge (HP:0000446)2.01290166
115Hyperglycinuria (HP:0003108)1.99559060
116Abnormal respiratory epithelium morphology (HP:0012253)1.97758377
117Abnormal respiratory motile cilium morphology (HP:0005938)1.97758377
118Vaginal fistula (HP:0004320)1.97628663
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97111719
120Volvulus (HP:0002580)1.96207408
121Incomplete penetrance (HP:0003829)1.95053896
122Impaired smooth pursuit (HP:0007772)1.94385403
123Fair hair (HP:0002286)1.93973441
124Gait imbalance (HP:0002141)1.93477285
125Pendular nystagmus (HP:0012043)1.92833075
126Hemiparesis (HP:0001269)1.92610372
127Gait ataxia (HP:0002066)1.92139876
128Optic disc pallor (HP:0000543)1.91767073
129Dysmetric saccades (HP:0000641)1.91584627
130Menstrual irregularities (HP:0000858)1.90878885
131Resting tremor (HP:0002322)1.89694202
132Cerebral edema (HP:0002181)1.88508740
133Gastroesophageal reflux (HP:0002020)1.88194050
134Nausea (HP:0002018)1.86449602
135Abnormality of the columella (HP:0009929)1.85916871
136Epidermoid cyst (HP:0200040)1.85235758
137Torticollis (HP:0000473)1.84457537
138Fetal akinesia sequence (HP:0001989)1.83240240
139Cupped ear (HP:0000378)1.83182878
140Hypothermia (HP:0002045)1.82743797
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82684077
142Abnormality of alanine metabolism (HP:0010916)1.82684077
143Hyperalaninemia (HP:0003348)1.82684077
144Ventricular fibrillation (HP:0001663)1.80367396
145Intestinal fistula (HP:0100819)1.79806691
146Abnormality of binocular vision (HP:0011514)1.78771461
147Diplopia (HP:0000651)1.78771461
148Generalized hypopigmentation of hair (HP:0011358)1.78660327
149Clonus (HP:0002169)1.78636268
150Lower limb asymmetry (HP:0100559)1.78307004
151Type II lissencephaly (HP:0007260)1.78089610
152Gastrointestinal atresia (HP:0002589)1.77827052
153Focal dystonia (HP:0004373)1.77320382
154Severe Myopia (HP:0011003)1.76076288
155Exotropia (HP:0000577)1.75647733
156Sparse lateral eyebrow (HP:0005338)1.75265495
157Urinary bladder sphincter dysfunction (HP:0002839)1.75139992
158Choanal stenosis (HP:0000452)1.71650874
159Unilateral renal agenesis (HP:0000122)1.70958920
160Renal hypoplasia (HP:0000089)1.70451879
161Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70319134
162Abnormal protein N-linked glycosylation (HP:0012347)1.70319134
163Abnormal protein glycosylation (HP:0012346)1.70319134
164Abnormal glycosylation (HP:0012345)1.70319134
165Adactyly (HP:0009776)1.70293503
166Genetic anticipation (HP:0003743)1.68582964
167Abnormality of chromosome stability (HP:0003220)1.67446869
168Back pain (HP:0003418)1.67444667
169Postnatal microcephaly (HP:0005484)1.66857104
170Pancreatic islet-cell hyperplasia (HP:0004510)1.65229912
171Maternal diabetes (HP:0009800)1.62625326
172Triphalangeal thumb (HP:0001199)1.60178018
173Abnormality of glycine metabolism (HP:0010895)1.59266012
174Abnormality of serine family amino acid metabolism (HP:0010894)1.59266012
175Neoplasm of the adrenal cortex (HP:0100641)1.58989988
176Partial duplication of the phalanx of hand (HP:0009999)1.58901345
177Ulnar claw (HP:0001178)1.58432944
178Chorioretinal atrophy (HP:0000533)1.57849343
179Cerebellar dysplasia (HP:0007033)1.55114032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.79664324
2EPHA44.14235513
3WNK34.12808114
4NTRK33.94817563
5MAP3K123.34859887
6MAP3K43.03000285
7MAP2K72.97106448
8MAP3K92.78141015
9RIPK42.44087032
10MINK12.37604939
11DAPK22.36899633
12PLK22.35190551
13LATS12.32471008
14TRIM282.24627322
15AKT32.23206119
16DYRK22.22489372
17CDK192.20523152
18NME12.16100516
19DAPK12.12060495
20MAP2K42.06046179
21CCNB11.97841674
22STK38L1.92780270
23TIE11.92599899
24MKNK21.85161729
25ARAF1.82423944
26NUAK11.73922329
27PNCK1.70115069
28MARK11.70097083
29SIK31.66987013
30PLK41.66010288
31GRK51.64458630
32MKNK11.59630845
33LIMK11.58595329
34PKN11.58369793
35EPHB21.56161460
36TESK11.55568174
37FRK1.53959945
38KSR11.51402906
39BMPR21.48765328
40CAMK41.45308370
41NTRK21.38635993
42VRK21.37012857
43CSNK1G31.34823111
44OXSR11.34239400
45KSR21.30448966
46PKN21.29581786
47TNIK1.29113962
48PTK2B1.29111366
49BRSK21.29017831
50PRPF4B1.28516534
51BMPR1B1.25193421
52KDR1.24689500
53CSNK1G11.24202217
54CSNK1A1L1.21631623
55CDK51.20579419
56PAK61.19763179
57CAMK2A1.17809534
58CAMKK21.13278915
59FES1.12672302
60ERBB31.12086484
61CAMK1D1.09260718
62VRK11.08289546
63BRAF1.08255524
64MAP3K131.07138599
65MUSK1.06892308
66PRKCG1.06495772
67CAMK2B1.03676744
68BCR1.01623043
69SIK20.97389823
70FGR0.94039780
71NTRK10.92700982
72NLK0.91569672
73PDK40.90672371
74PDK30.90672371
75INSRR0.89491159
76TGFBR20.88136705
77OBSCN0.84978440
78CAMKK10.84639882
79MAPK130.84593436
80MAP4K20.81802963
81MAP3K50.81104138
82DYRK30.81015695
83RAF10.79041256
84YES10.78491536
85GRK60.77821975
86PRKAA20.77500492
87CDK180.76162921
88SGK2230.73286845
89SGK4940.73286845
90MAP3K70.71562198
91PBK0.71129775
92PRKACB0.70715077
93CDK140.69101985
94TSSK60.68103593
95SGK20.66729097
96CDK150.66063291
97GRK70.66012890
98PRKCE0.65755529
99TGFBR10.65331706
100FER0.65004899
101ADRBK10.64566971
102ROCK10.63124032
103STK110.61251725
104UHMK10.61238151
105ADRBK20.59573297
106CSNK1E0.57738519
107CAMK10.57219826
108IRAK20.56371912
109CAMK1G0.56340101
110ZAK0.55928839
111CDK11A0.55227752
112STK30.54001377
113MAPK40.53748219
114GRK10.52524137
115MYLK0.51847358
116DAPK30.51743441
117LATS20.51533253
118FLT30.49131627
119NEK10.48708639
120MAP3K20.46886372
121SGK10.46249042
122CAMK2D0.46106637
123PRKG10.43109304
124FGFR10.42302686
125TYRO30.42204208
126PRKDC0.42071887
127DYRK1A0.41743443
128CAMK2G0.41578660
129PAK30.41486878
130FGFR20.41295671
131CDK30.40974464
132STK380.40613380
133MAP3K60.40487083
134PDPK10.40277456
135MAPK70.39698291
136PRKACA0.39597221
137PRKD30.39566573
138PRKACG0.39370769
139PASK0.38475104
140ROCK20.38395340
141PDK20.37156845
142PLK10.36427687
143MAP2K10.36417575
144SGK30.35633117
145MAP3K10.33675941
146CSNK1G20.33337551
147PRKCZ0.33037563
148PDK10.31576100
149PLK30.31099927
150PHKG10.30819358
151PHKG20.30819358
152STK390.30814113
153FYN0.29971165
154PINK10.29458317
155MAPK120.28787803
156PRKCH0.28107957
157RPS6KA30.27837661
158RET0.27364924

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.51224566
2Synaptic vesicle cycle_Homo sapiens_hsa047213.86295677
3Collecting duct acid secretion_Homo sapiens_hsa049663.34873401
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.99371030
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.96178908
6Vitamin B6 metabolism_Homo sapiens_hsa007502.69924162
7Amphetamine addiction_Homo sapiens_hsa050312.69745850
8GABAergic synapse_Homo sapiens_hsa047272.69572135
9Long-term potentiation_Homo sapiens_hsa047202.67957738
10Morphine addiction_Homo sapiens_hsa050322.62519962
11Circadian entrainment_Homo sapiens_hsa047132.57112381
12Oxidative phosphorylation_Homo sapiens_hsa001902.51298619
13Olfactory transduction_Homo sapiens_hsa047402.39130954
14Propanoate metabolism_Homo sapiens_hsa006402.31086941
15Glutamatergic synapse_Homo sapiens_hsa047242.27236615
16Dopaminergic synapse_Homo sapiens_hsa047282.15574658
17Fatty acid elongation_Homo sapiens_hsa000622.07803467
18Salivary secretion_Homo sapiens_hsa049702.02590769
19Serotonergic synapse_Homo sapiens_hsa047261.99290708
20Taste transduction_Homo sapiens_hsa047421.96010529
21Vibrio cholerae infection_Homo sapiens_hsa051101.95978741
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89778807
23Renin secretion_Homo sapiens_hsa049241.82734185
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77686543
25Long-term depression_Homo sapiens_hsa047301.77373654
26Fatty acid metabolism_Homo sapiens_hsa012121.76957966
27Alzheimers disease_Homo sapiens_hsa050101.75701079
28Parkinsons disease_Homo sapiens_hsa050121.70441964
29Insulin secretion_Homo sapiens_hsa049111.69812984
30Cocaine addiction_Homo sapiens_hsa050301.65776606
31PPAR signaling pathway_Homo sapiens_hsa033201.56134662
32Calcium signaling pathway_Homo sapiens_hsa040201.55995773
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54620950
34Steroid biosynthesis_Homo sapiens_hsa001001.53839936
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53716376
36Oxytocin signaling pathway_Homo sapiens_hsa049211.51153839
37Cardiac muscle contraction_Homo sapiens_hsa042601.49628581
38Cholinergic synapse_Homo sapiens_hsa047251.48748177
39Gastric acid secretion_Homo sapiens_hsa049711.47856347
40Folate biosynthesis_Homo sapiens_hsa007901.43188377
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42368181
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.41326919
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.40452156
44* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40360959
45Fanconi anemia pathway_Homo sapiens_hsa034601.31386449
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27855836
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27265976
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25080468
49Fat digestion and absorption_Homo sapiens_hsa049751.22892457
50Fatty acid degradation_Homo sapiens_hsa000711.22260972
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21588615
52Basal transcription factors_Homo sapiens_hsa030221.21122725
53Fatty acid biosynthesis_Homo sapiens_hsa000611.19290863
54RNA degradation_Homo sapiens_hsa030181.18049960
55GnRH signaling pathway_Homo sapiens_hsa049121.14064295
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12801878
57Huntingtons disease_Homo sapiens_hsa050161.12619199
58Phototransduction_Homo sapiens_hsa047441.10706425
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08204119
60beta-Alanine metabolism_Homo sapiens_hsa004101.07575415
61cAMP signaling pathway_Homo sapiens_hsa040241.06331667
62Gap junction_Homo sapiens_hsa045401.06109398
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05596094
64Hippo signaling pathway_Homo sapiens_hsa043901.04005914
65Glycerolipid metabolism_Homo sapiens_hsa005611.01917968
66Rheumatoid arthritis_Homo sapiens_hsa053231.00013464
67Tight junction_Homo sapiens_hsa045300.99496977
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95309608
69Adherens junction_Homo sapiens_hsa045200.94809737
70Nitrogen metabolism_Homo sapiens_hsa009100.94693524
71Axon guidance_Homo sapiens_hsa043600.90353116
72Estrogen signaling pathway_Homo sapiens_hsa049150.87988587
73Tryptophan metabolism_Homo sapiens_hsa003800.85783800
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84792031
75Melanogenesis_Homo sapiens_hsa049160.84510205
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84108479
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82941548
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82476198
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.82340605
80Selenocompound metabolism_Homo sapiens_hsa004500.81178261
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81097241
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80127443
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80000450
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78832267
85Phenylalanine metabolism_Homo sapiens_hsa003600.76573935
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76347542
87Retinol metabolism_Homo sapiens_hsa008300.75183597
88Glioma_Homo sapiens_hsa052140.75171129
89One carbon pool by folate_Homo sapiens_hsa006700.74947665
90Mismatch repair_Homo sapiens_hsa034300.74009878
91Type I diabetes mellitus_Homo sapiens_hsa049400.73045811
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71969312
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71023110
94mRNA surveillance pathway_Homo sapiens_hsa030150.70029364
95Protein export_Homo sapiens_hsa030600.69713502
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.67479495
97ErbB signaling pathway_Homo sapiens_hsa040120.67118122
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64902857
99Histidine metabolism_Homo sapiens_hsa003400.64521154
100Glucagon signaling pathway_Homo sapiens_hsa049220.64278223
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.64061592
102Lysine degradation_Homo sapiens_hsa003100.61127740
103Oocyte meiosis_Homo sapiens_hsa041140.60016054
104Type II diabetes mellitus_Homo sapiens_hsa049300.59080338
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58676048
106TGF-beta signaling pathway_Homo sapiens_hsa043500.58588867
107AMPK signaling pathway_Homo sapiens_hsa041520.58330312
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57846188
109RNA transport_Homo sapiens_hsa030130.57583262
110Homologous recombination_Homo sapiens_hsa034400.57054427
111MAPK signaling pathway_Homo sapiens_hsa040100.56991949
112Pancreatic secretion_Homo sapiens_hsa049720.56282383
113Chemical carcinogenesis_Homo sapiens_hsa052040.56216233
114Basal cell carcinoma_Homo sapiens_hsa052170.54889338
115Dilated cardiomyopathy_Homo sapiens_hsa054140.54862108
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53911222
117Linoleic acid metabolism_Homo sapiens_hsa005910.52732294
118Phagosome_Homo sapiens_hsa041450.52189022
119Dorso-ventral axis formation_Homo sapiens_hsa043200.51499267
120Ras signaling pathway_Homo sapiens_hsa040140.48107784
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48011349
122Pyruvate metabolism_Homo sapiens_hsa006200.47671893
123Thyroid hormone synthesis_Homo sapiens_hsa049180.46947919
124Alcoholism_Homo sapiens_hsa050340.46605275
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.45972905
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44304920
127Butanoate metabolism_Homo sapiens_hsa006500.43076044
128African trypanosomiasis_Homo sapiens_hsa051430.41535997
129Circadian rhythm_Homo sapiens_hsa047100.39041643
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38100193
131Choline metabolism in cancer_Homo sapiens_hsa052310.37714012
132Prion diseases_Homo sapiens_hsa050200.36208922
133Rap1 signaling pathway_Homo sapiens_hsa040150.31827154
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31479617
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31469756
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30217440
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.29956947
138VEGF signaling pathway_Homo sapiens_hsa043700.29712775
139Inositol phosphate metabolism_Homo sapiens_hsa005620.29252684
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25300596
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25207170
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24240793
143Ovarian steroidogenesis_Homo sapiens_hsa049130.21743127
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20957175
145Bile secretion_Homo sapiens_hsa049760.20866597
146Melanoma_Homo sapiens_hsa052180.19842903
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.18728995
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17281982
149Insulin signaling pathway_Homo sapiens_hsa049100.17267228
150Wnt signaling pathway_Homo sapiens_hsa043100.17220314
151Renal cell carcinoma_Homo sapiens_hsa052110.16827249
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.15353092
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13270990

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