NPY6R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.85018083
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO8.26099188
3regulation of relaxation of muscle (GO:1901077)7.96952784
4potassium ion homeostasis (GO:0055075)7.93700709
5muscle filament sliding (GO:0030049)7.93484760
6actin-myosin filament sliding (GO:0033275)7.93484760
7regulation of actin filament-based movement (GO:1903115)7.80815251
8cardiac myofibril assembly (GO:0055003)7.75694479
9cardiac muscle contraction (GO:0060048)7.72431591
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)7.68146480
11regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)7.52936214
12myofibril assembly (GO:0030239)7.32750236
13regulation of cell communication by electrical coupling (GO:0010649)6.91733967
14cardiac muscle hypertrophy (GO:0003300)6.78398141
15sarcoplasmic reticulum calcium ion transport (GO:0070296)6.62410106
16actin-mediated cell contraction (GO:0070252)6.61056917
17hypotonic response (GO:0006971)6.48912543
18striated muscle hypertrophy (GO:0014897)6.41473244
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)6.24426917
20striated muscle contraction (GO:0006941)6.19933464
21regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)6.10420422
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.04145690
23ventricular cardiac muscle cell action potential (GO:0086005)5.94351714
24cardiac muscle tissue morphogenesis (GO:0055008)5.93583367
25bundle of His cell to Purkinje myocyte communication (GO:0086069)5.92432880
26cell communication involved in cardiac conduction (GO:0086065)5.84384253
27NADH metabolic process (GO:0006734)5.81990439
28regulation of cardiac muscle cell contraction (GO:0086004)5.80370452
29muscle hypertrophy (GO:0014896)5.77081527
30actomyosin structure organization (GO:0031032)5.75778022
31ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.73933660
32regulation of the force of heart contraction (GO:0002026)5.69433269
33negative regulation of potassium ion transmembrane transport (GO:1901380)5.67271036
34adult heart development (GO:0007512)5.60239403
35cardiac muscle cell development (GO:0055013)5.59894587
36muscle tissue morphogenesis (GO:0060415)5.40340121
37regulation of striated muscle contraction (GO:0006942)5.32243380
38response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.23899204
39cardiac cell development (GO:0055006)5.19983150
40cell communication by electrical coupling (GO:0010644)5.15778316
41carnitine shuttle (GO:0006853)5.05333723
42heart process (GO:0003015)5.02594930
43heart contraction (GO:0060047)5.02594930
44sodium ion homeostasis (GO:0055078)5.01072620
45detection of calcium ion (GO:0005513)5.00432176
46actin filament-based movement (GO:0030048)4.89029194
47regulation of heart rate (GO:0002027)4.79240444
48response to inactivity (GO:0014854)4.76456464
49regulation of cardiac muscle contraction (GO:0055117)4.67688688
50regulation of membrane repolarization (GO:0060306)4.63428638
51relaxation of cardiac muscle (GO:0055119)4.55750191
52positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.52554708
53regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.49415095
54fatty acid transmembrane transport (GO:1902001)4.48426354
55creatine metabolic process (GO:0006600)4.41626352
56cardiac muscle hypertrophy in response to stress (GO:0014898)4.41426148
57muscle hypertrophy in response to stress (GO:0003299)4.41426148
58cardiac muscle adaptation (GO:0014887)4.41426148
59cardiac muscle cell action potential (GO:0086001)4.39243508
60xenobiotic catabolic process (GO:0042178)4.36630731
61positive regulation of heart rate (GO:0010460)4.34017225
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.33445664
63cardiac muscle cell action potential involved in contraction (GO:0086002)4.28034376
64regulation of ATP catabolic process (GO:1903289)4.24620254
65regulation of ATPase activity (GO:0043462)4.24620254
66extracellular matrix assembly (GO:0085029)4.20423939
67tricarboxylic acid cycle (GO:0006099)4.17094030
68tonic smooth muscle contraction (GO:0014820)4.10014012
69regulation of heart contraction (GO:0008016)4.08303576
70response to epinephrine (GO:0071871)4.07162414
71cellular response to epinephrine stimulus (GO:0071872)4.01921419
72muscle contraction (GO:0006936)3.98825813
73response to caffeine (GO:0031000)3.95522054
74regulation of sarcomere organization (GO:0060297)3.94820028
75carnitine transmembrane transport (GO:1902603)3.93310970
76positive regulation of action potential (GO:0045760)3.93022191
77skeletal muscle contraction (GO:0003009)3.88131720
78cardiac conduction (GO:0061337)3.87757615
79adrenergic receptor signaling pathway (GO:0071875)3.86790727
80regulation of calcium ion transmembrane transporter activity (GO:1901019)3.83177752
81regulation of calcium ion transmembrane transport (GO:1903169)3.83177752
82sulfur amino acid catabolic process (GO:0000098)3.82624607
83regulation of cardioblast differentiation (GO:0051890)3.80853628
84cardiac chamber formation (GO:0003207)3.79577497
85glomerulus development (GO:0032835)3.78756399
86galactose metabolic process (GO:0006012)3.75799618
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.71532857
88carnitine transport (GO:0015879)3.70028739
89amino-acid betaine transport (GO:0015838)3.70028739
90tricarboxylic acid metabolic process (GO:0072350)3.69645684
91muscle system process (GO:0003012)3.68460312
92regulation of sequestering of triglyceride (GO:0010889)3.67946980
93cardiac ventricle formation (GO:0003211)3.67458312
94water transport (GO:0006833)3.63980697
95phenylpropanoid metabolic process (GO:0009698)3.61970381
96striated muscle adaptation (GO:0014888)3.57206016
97neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.57173472
98cell differentiation involved in metanephros development (GO:0072202)3.54773296
99positive regulation of heart contraction (GO:0045823)3.54037935
100regulation of muscle contraction (GO:0006937)3.53729210
101regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.49454088
102negative regulation of calcium ion transmembrane transport (GO:1903170)3.45539664
103negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.45539664
104positive regulation of cation channel activity (GO:2001259)3.40981211
105regulation of apoptotic process involved in morphogenesis (GO:1902337)3.38886333
106positive regulation of sodium ion transport (GO:0010765)3.38348777
107regulation of muscle system process (GO:0090257)3.33325086
108protein autoprocessing (GO:0016540)3.33128051
109negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.31728051
110relaxation of muscle (GO:0090075)3.27044879
111glyoxylate metabolic process (GO:0046487)3.27023418
1122-oxoglutarate metabolic process (GO:0006103)3.23925523
113regulation of cation channel activity (GO:2001257)3.23822288
114lung vasculature development (GO:0060426)3.19915842
115metanephric mesenchyme development (GO:0072075)3.14117506
116fluid transport (GO:0042044)3.13500850
117endocardial cushion morphogenesis (GO:0003203)3.13477638
118negative regulation of cardiac muscle hypertrophy (GO:0010614)3.12280675
119glucuronate metabolic process (GO:0019585)3.12174675
120uronic acid metabolic process (GO:0006063)3.12174675
121regulation of protein glycosylation (GO:0060049)3.10600120
122smooth muscle contraction (GO:0006939)3.08404621
123protein localization to cell surface (GO:0034394)2.98733451
124platelet aggregation (GO:0070527)2.98352349
125cellular response to osmotic stress (GO:0071470)2.96009974
126cGMP-mediated signaling (GO:0019934)2.91523573
127gap junction assembly (GO:0016264)2.89740702
128angiogenesis involved in wound healing (GO:0060055)2.80344860
129regulation of plasminogen activation (GO:0010755)2.78796698
130cellular modified amino acid catabolic process (GO:0042219)2.78158189
131regulation of clathrin-mediated endocytosis (GO:2000369)2.76312299
132L-ascorbic acid metabolic process (GO:0019852)2.74655078
133negative regulation of sodium ion transport (GO:0010766)2.73266813
134endocrine hormone secretion (GO:0060986)2.72814880
135kidney mesenchyme development (GO:0072074)2.71839205
136negative regulation of muscle hypertrophy (GO:0014741)2.70844478
137nephron epithelium morphogenesis (GO:0072088)2.68454166
138nephron tubule morphogenesis (GO:0072078)2.68454166
139regulation of skeletal muscle contraction (GO:0014819)2.68388343
140mesenchyme morphogenesis (GO:0072132)2.66698805
141positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.65761365
142ethanol metabolic process (GO:0006067)2.65534718
143protein heterotrimerization (GO:0070208)2.65313891
144protein retention in ER lumen (GO:0006621)2.64117941
145cellular glucuronidation (GO:0052695)2.62164503
146fucose catabolic process (GO:0019317)2.60451327
147L-fucose metabolic process (GO:0042354)2.60451327
148L-fucose catabolic process (GO:0042355)2.60451327
149N-glycan processing (GO:0006491)2.58549166
150camera-type eye morphogenesis (GO:0048593)2.58339372
151renal tubule morphogenesis (GO:0061333)2.57763801
152relaxation of smooth muscle (GO:0044557)2.55876753
153renal system development (GO:0072001)2.55587283
154regulation of cardiac muscle hypertrophy (GO:0010611)2.55216679
155metanephric nephron tubule development (GO:0072234)2.52302093
156metanephric tubule development (GO:0072170)2.52302093
157primary alcohol catabolic process (GO:0034310)2.51490639
158endothelial cell morphogenesis (GO:0001886)2.50216218
159galactose catabolic process (GO:0019388)2.49017475
160glutathione metabolic process (GO:0006749)2.48110221
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.47936940
162glutathione derivative biosynthetic process (GO:1901687)2.47339137
163glutathione derivative metabolic process (GO:1901685)2.47339137
164nephron epithelium development (GO:0072009)2.46945152
165regulation of synapse structural plasticity (GO:0051823)2.46833284
166negative regulation of cardiac muscle tissue growth (GO:0055022)2.46576848
167negative regulation of heart growth (GO:0061117)2.46576848
168negative regulation of epidermal cell differentiation (GO:0045605)2.45222627
169spindle assembly involved in mitosis (GO:0090307)2.43714346
170negative regulation of embryonic development (GO:0045992)2.42122972
171regulation of muscle hypertrophy (GO:0014743)2.41983421
172stress fiber assembly (GO:0043149)2.39979908
173aldehyde catabolic process (GO:0046185)2.39704665
174benzene-containing compound metabolic process (GO:0042537)2.38629029
175negative regulation of cytosolic calcium ion concentration (GO:0051481)2.37541233
176nephron tubule development (GO:0072080)2.37485317
177respiratory tube development (GO:0030323)2.37397947
178planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36752442
179epithelial cell differentiation involved in kidney development (GO:0035850)2.36512900
180cellular ketone body metabolic process (GO:0046950)2.35994918
181vascular smooth muscle contraction (GO:0014829)2.35727488
182polyol transport (GO:0015791)2.35155597
183regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.34153637
184vasoconstriction (GO:0042310)2.34147676
185homotypic cell-cell adhesion (GO:0034109)2.31667400
186endocardial cushion development (GO:0003197)2.30817510
187cysteine metabolic process (GO:0006534)2.28101569
188growth hormone secretion (GO:0030252)2.27993728
189midgut development (GO:0007494)2.27640367
190regulation of muscle adaptation (GO:0043502)2.27582657
191metanephric nephron epithelium development (GO:0072243)2.27436745
192aminoglycoside antibiotic metabolic process (GO:0030647)2.27124255
193lung morphogenesis (GO:0060425)2.26369865
194cell differentiation involved in kidney development (GO:0061005)2.25965298
195regulation of cholesterol homeostasis (GO:2000188)2.24170603
196early endosome to late endosome transport (GO:0045022)2.23993438
197one-carbon compound transport (GO:0019755)11.7779916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.17589130
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.91665498
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.86246400
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.15110674
5TBX20_22328084_ChIP-Seq_HEART_Mouse3.11744630
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.11744630
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.81145718
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.67056665
9VDR_22108803_ChIP-Seq_LS180_Human2.56770527
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.52900907
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.46945817
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35220110
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.32524353
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15268755
15GATA1_22025678_ChIP-Seq_K562_Human2.11907514
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.10067013
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.02550893
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01372369
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00904724
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.00817729
21ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.98286684
22CLOCK_20551151_ChIP-Seq_293T_Human1.96962860
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94492242
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94106736
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.88136003
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87863204
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87863204
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85826891
29EZH2_22144423_ChIP-Seq_EOC_Human1.85518612
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.85424917
31GATA4_21415370_ChIP-Seq_HL-1_Mouse1.84918535
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82467776
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80294514
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78449881
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.76432609
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74784684
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.73458173
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72164375
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71714646
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.69114432
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68604290
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67877558
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65428093
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61733624
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61322925
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55050178
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54959536
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52404695
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51756108
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.50330948
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.48548327
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46996739
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46054334
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44776839
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44776839
56GBX2_23144817_ChIP-Seq_PC3_Human1.40921318
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.40130783
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39932738
59TP53_18474530_ChIP-ChIP_U2OS_Human1.39079274
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.39040008
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38429922
62SOX2_20726797_ChIP-Seq_SW620_Human1.36058845
63CJUN_26792858_Chip-Seq_BT549_Human1.35844236
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35664743
65TP53_16413492_ChIP-PET_HCT116_Human1.32570231
66NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.31424270
67SMAD4_21799915_ChIP-Seq_A2780_Human1.31124740
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.30988335
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30473562
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30379929
71RACK7_27058665_Chip-Seq_MCF-7_Human1.30190259
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27487931
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26394931
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25337652
75ZNF263_19887448_ChIP-Seq_K562_Human1.23882026
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23435045
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22659744
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20963737
79LXR_22292898_ChIP-Seq_THP-1_Human1.20679878
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18096216
81AHR_22903824_ChIP-Seq_MCF-7_Human1.17243087
82KLF5_25053715_ChIP-Seq_YYC3_Human1.16291980
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15831236
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15188400
85* PIAS1_25552417_ChIP-Seq_VCAP_Human1.12971698
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.12669653
87BCAT_22108803_ChIP-Seq_LS180_Human1.12489451
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.12332690
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11331550
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.10910819
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09396263
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09033843
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08962877
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08934123
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05101711
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.04887592
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03931513
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.03582515
99* TCF4_23295773_ChIP-Seq_U87_Human1.02945601
100KDM2B_26808549_Chip-Seq_K562_Human1.02815047
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02770061
102PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02576660
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.02503144
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01443699
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00870639
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00482121
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99582213
108TBL1_22424771_ChIP-Seq_293T_Human0.99562375
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98551199
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98513639
111RXR_22158963_ChIP-Seq_LIVER_Mouse0.97521527
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.97516231
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.97455091
114LXR_22158963_ChIP-Seq_LIVER_Mouse0.97422698
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97366062
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.97185620
117DROSHA_22980978_ChIP-Seq_HELA_Human0.96402563
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96340421
119NFE2_27457419_Chip-Seq_LIVER_Mouse0.95652555
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.95592418
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95570125
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.95208227
123CBX2_27304074_Chip-Seq_ESCs_Mouse0.95097354
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94649508
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94441034
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.93920601
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93515135
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.93110648
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93076247
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92109590
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91702577
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91501014
133STAT3_23295773_ChIP-Seq_U87_Human0.91035890
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89717328
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89548749
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89480341
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89186737
138RING1B_27294783_Chip-Seq_NPCs_Mouse0.88200401
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87972404
140CDX2_22108803_ChIP-Seq_LS180_Human0.87955438
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87620008
142EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86287087
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86259137
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86198436
145GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86159490
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84139675
147* SMAD4_21741376_ChIP-Seq_HESCs_Human0.83999096
148RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83813570
149HNFA_21074721_ChIP-Seq_CACO-2_Human0.83667935
150TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83572704
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83540319
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83460569
153NFYB_21822215_ChIP-Seq_K562_Human0.83233926
154EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83163892
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82236614
156RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82182059
157FOXO3_23340844_ChIP-Seq_DLD1_Human0.82156643
158ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81723774
159ZNF274_21170338_ChIP-Seq_K562_Hela0.81538077
160TP63_22573176_ChIP-Seq_HFKS_Human0.81058547
161PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80827659
162POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80280072
163CRX_20693478_ChIP-Seq_RETINA_Mouse0.79995135
164SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79924927
165CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79553397
166PHF8_20622853_ChIP-Seq_HELA_Human0.79390809
167OCT4_21477851_ChIP-Seq_ESCs_Mouse0.79330480
168SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.79081688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder8.71069847
2MP0005367_renal/urinary_system_phenotyp8.63759278
3MP0000516_abnormal_urinary_system8.63759278
4MP0004084_abnormal_cardiac_muscle6.39667013
5MP0004215_abnormal_myocardial_fiber5.03263218
6MP0003646_muscle_fatigue4.19367520
7MP0000534_abnormal_ureter_morphology3.99536268
8MP0000749_muscle_degeneration3.72986463
9MP0004510_myositis3.59373534
10MP0004484_altered_response_of3.48574612
11MP0001756_abnormal_urination3.41389064
12MP0008775_abnormal_heart_ventricle3.13208270
13MP0004087_abnormal_muscle_fiber3.00675350
14MP0006138_congestive_heart_failure2.88279319
15MP0004145_abnormal_muscle_electrophysio2.81010816
16MP0005385_cardiovascular_system_phenoty2.80493296
17MP0001544_abnormal_cardiovascular_syste2.80493296
18MP0003137_abnormal_impulse_conducting2.79840874
19MP0005423_abnormal_somatic_nervous2.59254828
20MP0010630_abnormal_cardiac_muscle2.55722789
21MP0001958_emphysema2.55581960
22MP0004130_abnormal_muscle_cell2.47541831
23MP0002106_abnormal_muscle_physiology2.46354022
24MP0000013_abnormal_adipose_tissue2.39280089
25MP0001986_abnormal_taste_sensitivity2.23255982
26MP0008438_abnormal_cutaneous_collagen2.22614244
27MP0002127_abnormal_cardiovascular_syste2.22024715
28MP0002269_muscular_atrophy2.19736979
29MP0000462_abnormal_digestive_system2.10699144
30MP0002822_catalepsy2.02092641
31MP0005369_muscle_phenotype2.00240206
32MP0002837_dystrophic_cardiac_calcinosis1.94691995
33MP0005165_increased_susceptibility_to1.92395422
34MP0000747_muscle_weakness1.88422969
35MP0000759_abnormal_skeletal_muscle1.76737350
36MP0002332_abnormal_exercise_endurance1.74325609
37MP0005623_abnormal_meninges_morphology1.65259886
38MP0010030_abnormal_orbit_morphology1.61406881
39MP0005275_abnormal_skin_tensile1.50848691
40MP0009643_abnormal_urine_homeostasis1.47791787
41MP0000538_abnormal_urinary_bladder1.43876972
42MP0005332_abnormal_amino_acid1.43189835
43MP0003828_pulmonary_edema1.43147818
44MP0001664_abnormal_digestion1.40579145
45MP0000230_abnormal_systemic_arterial1.38468447
46MP0003279_aneurysm1.35916282
47MP0004272_abnormal_basement_membrane1.32001981
48MP0006036_abnormal_mitochondrial_physio1.31911054
49MP0003221_abnormal_cardiomyocyte_apopto1.30537630
50MP0003252_abnormal_bile_duct1.22097574
51MP0000751_myopathy1.20502810
52MP0005503_abnormal_tendon_morphology1.16011678
53MP0005620_abnormal_muscle_contractility1.11870747
54MP0002136_abnormal_kidney_physiology1.09763812
55MP0005330_cardiomyopathy1.07742476
56MP0005164_abnormal_response_to1.03598385
57MP0005266_abnormal_metabolism1.02961811
58MP0001765_abnormal_ion_homeostasis1.02027873
59MP0004233_abnormal_muscle_weight1.01666662
60MP0003566_abnormal_cell_adhesion1.01387942
61MP0000266_abnormal_heart_morphology0.99487581
62MP0005023_abnormal_wound_healing0.99008835
63MP0005666_abnormal_adipose_tissue0.98262125
64MP0002108_abnormal_muscle_morphology0.96684146
65MP0005451_abnormal_body_composition0.93576799
66MP0001270_distended_abdomen0.90107088
67MP0004043_abnormal_pH_regulation0.87624450
68MP0010368_abnormal_lymphatic_system0.87482751
69MP0003705_abnormal_hypodermis_morpholog0.84083812
70MP0003950_abnormal_plasma_membrane0.81388830
71MP0002735_abnormal_chemical_nociception0.80811063
72MP0003283_abnormal_digestive_organ0.80676823
73MP0000003_abnormal_adipose_tissue0.78910128
74MP0008004_abnormal_stomach_pH0.78783940
75MP0006054_spinal_hemorrhage0.78737976
76MP0005595_abnormal_vascular_smooth0.77938671
77MP0001661_extended_life_span0.76287350
78MP0005360_urolithiasis0.76139339
79MP0000343_altered_response_to0.75644981
80MP0008875_abnormal_xenobiotic_pharmacok0.74918549
81MP0005381_digestive/alimentary_phenotyp0.74804064
82MP0002249_abnormal_larynx_morphology0.74593577
83MP0004858_abnormal_nervous_system0.74315358
84MP0002282_abnormal_trachea_morphology0.71553438
85MP0004883_abnormal_blood_vessel0.71501506
86MP0003385_abnormal_body_wall0.71081566
87MP0002128_abnormal_blood_circulation0.70013020
88MP0002135_abnormal_kidney_morphology0.68457932
89MP0004036_abnormal_muscle_relaxation0.68293069
90MP0003045_fibrosis0.68239427
91MP0003878_abnormal_ear_physiology0.68029282
92MP0005377_hearing/vestibular/ear_phenot0.68029282
93MP0004019_abnormal_vitamin_homeostasis0.67783855
94MP0009840_abnormal_foam_cell0.66291339
95MP0001346_abnormal_lacrimal_gland0.66175001
96MP0002139_abnormal_hepatobiliary_system0.65463240
97MP0004885_abnormal_endolymph0.64653853
98MP0002971_abnormal_brown_adipose0.62986426
99MP0002009_preneoplasia0.62928517
100MP0005197_abnormal_uvea_morphology0.62473913
101MP0002166_altered_tumor_susceptibility0.62350452
102MP0004859_abnormal_synaptic_plasticity0.61076276
103MP0003191_abnormal_cellular_cholesterol0.59108450
104MP0005508_abnormal_skeleton_morphology0.54803869
105MP0003567_abnormal_fetal_cardiomyocyte0.54261586
106MP0009780_abnormal_chondrocyte_physiolo0.53982306
107MP0002234_abnormal_pharynx_morphology0.53815297
108MP0002896_abnormal_bone_mineralization0.53768089
109MP0002928_abnormal_bile_duct0.52840386
110MP0001879_abnormal_lymphatic_vessel0.52673235
111MP0000733_abnormal_muscle_development0.51386517
112MP0005670_abnormal_white_adipose0.50342186
113MP0001299_abnormal_eye_distance/0.50144004
114MP0005085_abnormal_gallbladder_physiolo0.50039093
115MP0005319_abnormal_enzyme/_coenzyme0.49889256
116MP0002060_abnormal_skin_morphology0.49264039
117MP0000613_abnormal_salivary_gland0.49069918
118MP0002909_abnormal_adrenal_gland0.49000601
119MP0003300_gastrointestinal_ulcer0.48998484
120MP0000163_abnormal_cartilage_morphology0.48935407
121MP0003186_abnormal_redox_activity0.47804721
122MP0002653_abnormal_ependyma_morphology0.47791002
123MP0003638_abnormal_response/metabolism_0.47091502
124MP0005375_adipose_tissue_phenotype0.47022844
125MP0004924_abnormal_behavior0.45363882
126MP0005386_behavior/neurological_phenoty0.45363882
127MP0009384_cardiac_valve_regurgitation0.45337177
128MP0005365_abnormal_bile_salt0.44320687
129MP0005535_abnormal_body_temperature0.43338967
130MP0002638_abnormal_pupillary_reflex0.43303622
131MP0010352_gastrointestinal_tract_polyps0.43066827
132MP0002078_abnormal_glucose_homeostasis0.43010574
133MP0001984_abnormal_olfaction0.42877594
134MP0006072_abnormal_retinal_apoptosis0.42807352
135MP0005187_abnormal_penis_morphology0.42764901
136MP0003122_maternal_imprinting0.42755467
137MP0009115_abnormal_fat_cell0.42035870
138MP0000537_abnormal_urethra_morphology0.41623404
139MP0002972_abnormal_cardiac_muscle0.41408460
140MP0004742_abnormal_vestibular_system0.40456136
141MP0002796_impaired_skin_barrier0.40061452
142MP0009250_abnormal_appendicular_skeleto0.39956229
143MP0000249_abnormal_blood_vessel0.39876696
144MP0005636_abnormal_mineral_homeostasis0.39684207
145MP0005166_decreased_susceptibility_to0.39667415
146MP0003942_abnormal_urinary_system0.39011542
147MP0003938_abnormal_ear_development0.38762957
148MP0005409_darkened_coat_color0.38700333
149MP0005334_abnormal_fat_pad0.38584838
150MP0008569_lethality_at_weaning0.38572155
151MP0000750_abnormal_muscle_regeneration0.38568067
152MP0004085_abnormal_heartbeat0.38420428
153MP0004147_increased_porphyrin_level0.36970922
154MP0002295_abnormal_pulmonary_circulatio0.36713623
155MP0005584_abnormal_enzyme/coenzyme_acti0.36485276
156MP0002118_abnormal_lipid_homeostasis0.35461484
157MP0006035_abnormal_mitochondrial_morpho0.32988421
158MP0000767_abnormal_smooth_muscle0.32830355
159MP0005376_homeostasis/metabolism_phenot0.30958406
160MP0005167_abnormal_blood-brain_barrier0.26794967
161MP0004270_analgesia0.25883808
162MP0002876_abnormal_thyroid_physiology0.22887122
163MP0003136_yellow_coat_color0.20785170
164MP0003948_abnormal_gas_homeostasis0.19762766
165MP0001501_abnormal_sleep_pattern0.19756756
166MP0003183_abnormal_peptide_metabolism0.18911568
167MP0003879_abnormal_hair_cell0.18776372
168MP0001784_abnormal_fluid_regulation0.18323862
169MP0001666_abnormal_nutrient_absorption0.17366916

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)9.25198895
2Aortic aneurysm (HP:0004942)9.07264614
3Bundle branch block (HP:0011710)8.58877232
4Aortic dissection (HP:0002647)8.18530599
5Ventricular tachycardia (HP:0004756)6.81738694
6Atrial fibrillation (HP:0005110)6.34958393
7Syncope (HP:0001279)5.99393993
8Abnormality of the calf musculature (HP:0001430)5.81146719
9Primary atrial arrhythmia (HP:0001692)5.77870044
10Lipoatrophy (HP:0100578)5.67614141
11Supraventricular tachycardia (HP:0004755)5.57254753
12Asymmetric septal hypertrophy (HP:0001670)5.53776269
13Gastrointestinal dysmotility (HP:0002579)5.45711631
14Supraventricular arrhythmia (HP:0005115)5.41597862
15Calf muscle hypertrophy (HP:0008981)5.39582928
16Neoplasm of the heart (HP:0100544)5.31463555
17Malnutrition (HP:0004395)5.29405227
18Heart block (HP:0012722)5.26578984
19Muscle hypertrophy of the lower extremities (HP:0008968)5.12169274
20EMG: myopathic abnormalities (HP:0003458)5.09132453
21Dilated cardiomyopathy (HP:0001644)5.06353062
22Abnormal atrioventricular conduction (HP:0005150)4.93752357
23Ventricular arrhythmia (HP:0004308)4.91798929
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.83447949
25Abnormality of the left ventricular outflow tract (HP:0011103)4.80694838
26Subaortic stenosis (HP:0001682)4.80694838
27Muscle fiber inclusion bodies (HP:0100299)4.78758912
28Nemaline bodies (HP:0003798)4.63910373
29Aortic regurgitation (HP:0001659)4.39963751
30Palpitations (HP:0001962)4.39737390
31Ventricular fibrillation (HP:0001663)4.39294912
32Cerebral aneurysm (HP:0004944)4.24293886
33Atrioventricular block (HP:0001678)4.24101635
34Ankle contracture (HP:0006466)4.10033760
35Dilatation of the ascending aorta (HP:0005111)4.00320874
36Exercise-induced myalgia (HP:0003738)3.88526533
37Neck muscle weakness (HP:0000467)3.85621785
38Exercise-induced muscle cramps (HP:0003710)3.84073164
39EMG: neuropathic changes (HP:0003445)3.83607215
40Myoglobinuria (HP:0002913)3.80866657
41Short hallux (HP:0010109)3.73928764
42Hydroureter (HP:0000072)3.72267455
43Centrally nucleated skeletal muscle fibers (HP:0003687)3.65222359
44Absent frontal sinuses (HP:0002688)3.59365738
45Rimmed vacuoles (HP:0003805)3.52582266
46Ragged-red muscle fibers (HP:0003200)3.51505258
47Abdominal situs inversus (HP:0003363)3.50032238
48Abnormality of abdominal situs (HP:0011620)3.50032238
49Aneurysm (HP:0002617)3.49983434
50Abnormal pupillary function (HP:0007686)3.49566548
51Ulnar bowing (HP:0003031)3.42842183
52Rhabdomyolysis (HP:0003201)3.42303782
53Left ventricular hypertrophy (HP:0001712)3.40037252
54Increased density of long bones (HP:0006392)3.34534522
55Aplasia/Hypoplasia of the hallux (HP:0008362)3.33973553
56Long toe (HP:0010511)3.32888713
57Spastic diplegia (HP:0001264)3.23166327
58Stridor (HP:0010307)3.20823672
59Prolonged QT interval (HP:0001657)3.13790890
60Areflexia of lower limbs (HP:0002522)3.13147719
61Difficulty running (HP:0009046)3.10481263
62Short 4th metacarpal (HP:0010044)3.09147418
63Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09147418
64Persistence of primary teeth (HP:0006335)3.01386900
65Scapular winging (HP:0003691)2.99834902
66Mesomelia (HP:0003027)2.94334621
67Abnormality of the foot musculature (HP:0001436)2.94271884
68Broad distal phalanx of finger (HP:0009836)2.93483608
69Abnormal EKG (HP:0003115)2.93021230
70Wrist flexion contracture (HP:0001239)2.87511214
71Arterial tortuosity (HP:0005116)2.86598536
72Bicuspid aortic valve (HP:0001647)2.85679845
73Abnormality of oral frenula (HP:0000190)2.79584192
74Vascular tortuosity (HP:0004948)2.79102426
75Facial diplegia (HP:0001349)2.78150278
76Osteolytic defects of the hand bones (HP:0009699)2.77133038
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.77133038
78Abnormality of skeletal muscle fiber size (HP:0012084)2.73744492
79Abnormal foot bone ossification (HP:0010675)2.71883360
80Generalized muscle weakness (HP:0003324)2.67854709
81Type 1 muscle fiber predominance (HP:0003803)2.62205957
82Hyperparathyroidism (HP:0000843)2.61671587
83Stroke (HP:0001297)2.58697074
84Mildly elevated creatine phosphokinase (HP:0008180)2.57825456
85Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.57064133
86Radial bowing (HP:0002986)2.56352086
87Camptodactyly of toe (HP:0001836)2.55703969
88Palmoplantar keratoderma (HP:0000982)2.55164674
89Abnormality of the 2nd finger (HP:0004100)2.52543317
90Sudden cardiac death (HP:0001645)2.50564016
91Broad face (HP:0000283)2.49101344
92Foot dorsiflexor weakness (HP:0009027)2.48551762
93Pulmonary artery stenosis (HP:0004415)2.48287335
94Premature rupture of membranes (HP:0001788)2.41760876
95Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.41496830
96Right ventricular cardiomyopathy (HP:0011663)2.38420560
97Abnormality of the calcaneus (HP:0008364)2.38231659
98Tarsal synostosis (HP:0008368)2.38027640
99Frequent falls (HP:0002359)2.36832110
100Shawl scrotum (HP:0000049)2.36781392
101Back pain (HP:0003418)2.34293706
102Abnormality of the right ventricle (HP:0001707)2.33247040
103Distal lower limb amyotrophy (HP:0008944)2.28131790
104Elbow flexion contracture (HP:0002987)2.26810318
105Abnormality of the 4th metacarpal (HP:0010012)2.25782949
106Soft skin (HP:0000977)2.21658216
107Abnormal ossification of hand bones (HP:0005921)2.20081936
108Increased mean platelet volume (HP:0011877)2.19684810
109Bowing of the arm (HP:0006488)2.19167651
110Bowed forearm bones (HP:0003956)2.19167651
111Ureteral stenosis (HP:0000071)2.18404551
112Synostosis involving bones of the lower limbs (HP:0009138)2.17921769
113Synostosis involving bones of the feet (HP:0009140)2.17921769
114Long foot (HP:0001833)2.12403025
115Selective tooth agenesis (HP:0001592)2.09289402
116Difficulty climbing stairs (HP:0003551)2.04229929
117Arachnodactyly (HP:0001166)2.04154900
118Abnormality of the tricuspid valve (HP:0001702)2.03934233
119Steppage gait (HP:0003376)2.02034493
120Ureteral obstruction (HP:0006000)2.01934559
121Muscular dystrophy (HP:0003560)1.98952192
122Muscle fiber splitting (HP:0003555)1.98044805
123Congestive heart failure (HP:0001635)1.95097278
124Knee flexion contracture (HP:0006380)1.95069729
125Broad metatarsal (HP:0001783)1.94616710
126Increased intramyocellular lipid droplets (HP:0012240)1.94356085
127Spinal rigidity (HP:0003306)1.93419503
128Submucous cleft hard palate (HP:0000176)1.93279592
129Bulbar palsy (HP:0001283)1.92933427
130Increased muscle lipid content (HP:0009058)1.90905600
131Increased variability in muscle fiber diameter (HP:0003557)1.90823956
132Wormian bones (HP:0002645)1.89565779
133Hypoplastic left heart (HP:0004383)1.89176144
134Dysmetric saccades (HP:0000641)1.88329682
135Myopathic facies (HP:0002058)1.87676728
136Limb-girdle muscle atrophy (HP:0003797)1.87200079
137Abnormality of the odontoid process (HP:0003310)1.87058015
138Hyporeflexia of lower limbs (HP:0002600)1.86826840
139Increased serum pyruvate (HP:0003542)1.86700476
140Myotonia (HP:0002486)1.86133097
141Hand muscle atrophy (HP:0009130)1.84516758
142Toxemia of pregnancy (HP:0100603)1.84300143
143Gowers sign (HP:0003391)1.83844594
144Abnormal cartilage morphology (HP:0002763)1.83416679
145Bradycardia (HP:0001662)1.82806752
146Abnormal platelet volume (HP:0011876)1.82462389
147Fragile skin (HP:0001030)1.82289584
148Joint contractures involving the joints of the feet (HP:0100492)1.81931631
149Flexion contracture of toe (HP:0005830)1.81931631
150Mitral valve prolapse (HP:0001634)1.81872289
151Protrusio acetabuli (HP:0003179)1.81637239
152Proximal amyotrophy (HP:0007126)1.80991597
153Abnormality of the frontal sinuses (HP:0002687)1.80197015
154Hyperglycinuria (HP:0003108)1.76422145
155Progressive muscle weakness (HP:0003323)1.76011301
156Carpal synostosis (HP:0009702)1.74743750
157Delayed closure of the anterior fontanelle (HP:0001476)1.73753773
158Peritonitis (HP:0002586)1.73567108
159Distal arthrogryposis (HP:0005684)1.72158050
160Distal upper limb amyotrophy (HP:0007149)1.71402293
161Upper limb amyotrophy (HP:0009129)1.71402293
162Increased connective tissue (HP:0009025)1.71090072
163Distal lower limb muscle weakness (HP:0009053)1.70716759
164Abnormality of glycolysis (HP:0004366)1.69713379
165Skin nodule (HP:0200036)1.69473705
166Congenital malformation of the right heart (HP:0011723)1.68462105
167Double outlet right ventricle (HP:0001719)1.68462105
168Spontaneous abortion (HP:0005268)1.67117522
169Lower limb amyotrophy (HP:0007210)1.65402705
170Abnormality of the shoulder girdle musculature (HP:0001435)1.65396771
171Femoral bowing (HP:0002980)1.61637141
172Omphalocele (HP:0001539)1.61527720
173Hypoplastic heart (HP:0001961)1.61051755
174Exercise intolerance (HP:0003546)1.60809761
175Fused cervical vertebrae (HP:0002949)1.59541684
176Absent toe (HP:0010760)1.59326634
177Abnormality of the endocardium (HP:0004306)1.53010216
178Late onset (HP:0003584)1.47941906
179Central scotoma (HP:0000603)1.45801480
180Round ear (HP:0100830)1.42534564
181Hepatic necrosis (HP:0002605)1.42306045
182Respiratory insufficiency due to muscle weakness (HP:0002747)1.42013221
183Oligomenorrhea (HP:0000876)1.40067674
184Abnormality of fatty-acid metabolism (HP:0004359)1.38926506
185Childhood onset (HP:0011463)1.37260075
186Progressive external ophthalmoplegia (HP:0000590)1.36436436
187Abnormal mitochondria in muscle tissue (HP:0008316)1.35804149
188Muscle stiffness (HP:0003552)1.31656039
189Hyperkalemia (HP:0002153)1.31560168
190Weak cry (HP:0001612)1.31494028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN8.22901866
2MYLK8.05666830
3OBSCN7.80072485
4DMPK2.92690414
5PAK22.65803886
6MST1R2.46818064
7MAPKAPK32.44221824
8PIK3CG2.38642787
9RIPK12.25612149
10EPHB22.24107294
11MUSK2.15974204
12PINK12.04350901
13DDR21.91117279
14MINK11.88302578
15ERN11.69976542
16LMTK21.69858831
17AKT31.69078475
18MARK11.65083576
19STK41.47480718
20NEK91.43039593
21EPHA31.42814332
22GRK71.40757415
23PRKAA21.35440959
24EEF2K1.33135844
25BLK1.26036119
26CAMK2G1.23188103
27OXSR11.19135631
28PRKAA11.15898762
29TRPM71.15184555
30TIE11.14080966
31STK391.13881763
32WNK41.13858809
33RPS6KA21.06452469
34RPS6KB21.06021117
35STK241.05823656
36MAP3K61.03511688
37ILK1.02837683
38DAPK31.01829405
39MAP2K31.00641823
40TGFBR20.98557957
41CAMK40.98473293
42EPHA20.97806125
43ROCK10.96638536
44PRKCE0.95903563
45PAK30.95191087
46LATS20.93553127
47LIMK10.91644021
48PAK10.90708751
49CDC42BPA0.87052384
50PIK3CA0.83237114
51MET0.82266222
52PDGFRA0.82012466
53NME20.81130336
54CAMK1G0.80414856
55NEK10.79645687
56CAMK2D0.74060987
57CLK10.73775794
58MAP3K50.73419190
59PHKG10.71565322
60PHKG20.71565322
61TESK10.71024852
62CAMK2B0.70721242
63PTK20.70217124
64CAMK10.67733703
65MAP2K40.67380583
66PRKACG0.66844943
67MAPK70.66297643
68GSK3A0.66059727
69LRRK20.65303911
70ACVR1B0.63466569
71RPS6KC10.63318526
72RPS6KL10.63318526
73TRIB30.61107756
74PRKACA0.60788635
75ROCK20.60762767
76ITK0.59232143
77FYN0.59205316
78SIK10.58798724
79EPHB10.58199043
80PBK0.56639219
81NTRK30.56405921
82PRKG10.56078292
83NLK0.54459781
84FER0.51418868
85AKT20.48751345
86MAP3K20.48273261
87PTK2B0.48099233
88SGK4940.47933187
89SGK2230.47933187
90MAPK120.47291192
91RPS6KA60.46562605
92CAMK1D0.45915902
93NTRK10.45840862
94STK380.44934655
95MAPKAPK20.43845649
96CDK190.42973816
97PTK60.42539136
98TAOK10.41969185
99MAP3K70.41790358
100TYRO30.41235219
101PKN10.40328558
102RPS6KA10.38459626
103MAP3K120.36309056
104PRKD10.36225269
105FGFR30.35977227
106INSRR0.35337911
107STK110.34906433
108MAPK130.34751333
109CAMK2A0.34133734
110RPS6KA30.33668559
111BMX0.33154446
112PRKG20.32546105
113BCKDK0.32208888
114PDPK10.31712835
115MARK30.30820723
116PRKCI0.30806217
117PRKACB0.30758432
118ERBB30.30056873
119PRKCH0.29121978
120SRC0.28737341
121SGK20.28654496
122STK38L0.27743840
123MAP3K30.26995628
124UHMK10.26952483
125DAPK20.26750487
126MST40.25702026
127SGK30.24962282
128WNK10.24228672
129ZAP700.23641456
130PKN20.23638110
131PDGFRB0.23437221
132PDK20.22975740
133FRK0.22893495
134MAPK40.22496139
135INSR0.21993518
136MAP2K10.21830037
137FES0.21318592
138PDK10.20846042
139MAP3K10.20687189
140LATS10.20372741
141MAPK110.18391167
142CCNB10.16849895
143PRKCA0.16777924
144FGFR40.14678918
145TNIK0.14320356
146SGK10.13866762
147ADRBK10.13772715
148MAPK100.13535103
149MAP2K60.11377088
150AKT10.08496912
151MAPK90.08329840

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.91950171
2Sulfur metabolism_Homo sapiens_hsa009203.00971750
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51241112
4Vascular smooth muscle contraction_Homo sapiens_hsa042702.42214848
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.34518089
6Bladder cancer_Homo sapiens_hsa052192.30653143
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21265817
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10040191
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04529559
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99835456
11Glutathione metabolism_Homo sapiens_hsa004801.87307240
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.81389951
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75828056
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74753031
15Arginine biosynthesis_Homo sapiens_hsa002201.73124791
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63753635
17Carbon metabolism_Homo sapiens_hsa012001.61366699
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57456831
19Collecting duct acid secretion_Homo sapiens_hsa049661.55756786
20Chemical carcinogenesis_Homo sapiens_hsa052041.54273274
21Arginine and proline metabolism_Homo sapiens_hsa003301.53051052
22ECM-receptor interaction_Homo sapiens_hsa045121.50885561
23Vibrio cholerae infection_Homo sapiens_hsa051101.49210835
24Focal adhesion_Homo sapiens_hsa045101.46428828
25Circadian rhythm_Homo sapiens_hsa047101.44103829
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42714838
27Gastric acid secretion_Homo sapiens_hsa049711.41496327
28Butanoate metabolism_Homo sapiens_hsa006501.40326270
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32911824
30Fatty acid metabolism_Homo sapiens_hsa012121.26670896
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21644110
32Tight junction_Homo sapiens_hsa045301.17811984
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17414826
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16883589
35Fat digestion and absorption_Homo sapiens_hsa049751.16811247
36Platelet activation_Homo sapiens_hsa046111.14933069
37Synaptic vesicle cycle_Homo sapiens_hsa047211.14065449
38beta-Alanine metabolism_Homo sapiens_hsa004101.11855879
39Insulin resistance_Homo sapiens_hsa049311.09594676
40Protein digestion and absorption_Homo sapiens_hsa049741.09029571
41Taste transduction_Homo sapiens_hsa047421.06687129
42Phenylalanine metabolism_Homo sapiens_hsa003601.03111368
43Histidine metabolism_Homo sapiens_hsa003401.02780393
44Linoleic acid metabolism_Homo sapiens_hsa005911.02168335
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01459314
46GABAergic synapse_Homo sapiens_hsa047270.99895904
47Oxytocin signaling pathway_Homo sapiens_hsa049210.97763091
48Dilated cardiomyopathy_Homo sapiens_hsa054140.95612176
49Circadian entrainment_Homo sapiens_hsa047130.95402043
50Glucagon signaling pathway_Homo sapiens_hsa049220.95247656
51Mineral absorption_Homo sapiens_hsa049780.94279302
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93730163
53Viral myocarditis_Homo sapiens_hsa054160.92774311
54Dopaminergic synapse_Homo sapiens_hsa047280.91469468
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90465369
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90384787
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.89341825
58Proteoglycans in cancer_Homo sapiens_hsa052050.89263398
59Oxidative phosphorylation_Homo sapiens_hsa001900.88141831
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88134168
61Ovarian steroidogenesis_Homo sapiens_hsa049130.87243014
62Bile secretion_Homo sapiens_hsa049760.86759685
63Propanoate metabolism_Homo sapiens_hsa006400.86055176
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82849105
65Pancreatic secretion_Homo sapiens_hsa049720.81694527
66Insulin signaling pathway_Homo sapiens_hsa049100.81661906
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81397799
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.80451883
69Starch and sucrose metabolism_Homo sapiens_hsa005000.79932261
70Pyruvate metabolism_Homo sapiens_hsa006200.79185206
71Nitrogen metabolism_Homo sapiens_hsa009100.78186680
72Cholinergic synapse_Homo sapiens_hsa047250.76476750
73Axon guidance_Homo sapiens_hsa043600.76246192
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75062220
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74823863
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74278949
77PPAR signaling pathway_Homo sapiens_hsa033200.72875861
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72053956
79Cardiac muscle contraction_Homo sapiens_hsa042600.71929260
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71643605
81Renin secretion_Homo sapiens_hsa049240.71497754
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71231098
83Tyrosine metabolism_Homo sapiens_hsa003500.70687725
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70457463
85Hippo signaling pathway_Homo sapiens_hsa043900.67592097
86Thyroid hormone synthesis_Homo sapiens_hsa049180.66386450
87Amphetamine addiction_Homo sapiens_hsa050310.65314973
88Tryptophan metabolism_Homo sapiens_hsa003800.64695157
89AMPK signaling pathway_Homo sapiens_hsa041520.64560241
90Fatty acid elongation_Homo sapiens_hsa000620.64509961
91Cocaine addiction_Homo sapiens_hsa050300.64264030
92Nicotine addiction_Homo sapiens_hsa050330.64227115
93GnRH signaling pathway_Homo sapiens_hsa049120.62286582
94Morphine addiction_Homo sapiens_hsa050320.62246196
95Fatty acid degradation_Homo sapiens_hsa000710.61739697
96Melanogenesis_Homo sapiens_hsa049160.61599991
97Amoebiasis_Homo sapiens_hsa051460.60092959
98Biosynthesis of amino acids_Homo sapiens_hsa012300.59765249
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58182234
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57378197
101Gap junction_Homo sapiens_hsa045400.55995034
102Glutamatergic synapse_Homo sapiens_hsa047240.55631757
103cAMP signaling pathway_Homo sapiens_hsa040240.55113510
104Alzheimers disease_Homo sapiens_hsa050100.54970865
105Insulin secretion_Homo sapiens_hsa049110.54742737
106ABC transporters_Homo sapiens_hsa020100.53970106
107Parkinsons disease_Homo sapiens_hsa050120.52244388
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52115195
109Salivary secretion_Homo sapiens_hsa049700.51173293
110Rap1 signaling pathway_Homo sapiens_hsa040150.50768860
111Calcium signaling pathway_Homo sapiens_hsa040200.49005447
112Salmonella infection_Homo sapiens_hsa051320.48094492
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47609007
114Renin-angiotensin system_Homo sapiens_hsa046140.46965853
115Peroxisome_Homo sapiens_hsa041460.46145925
116N-Glycan biosynthesis_Homo sapiens_hsa005100.45877634
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45817509
118Huntingtons disease_Homo sapiens_hsa050160.45529337
119Phagosome_Homo sapiens_hsa041450.44721091
120Galactose metabolism_Homo sapiens_hsa000520.44000835
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43881179
122Fructose and mannose metabolism_Homo sapiens_hsa000510.43652499
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42820146
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.42581385
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41049866
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40032608
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.38769100
128Lysosome_Homo sapiens_hsa041420.38486736
129Arachidonic acid metabolism_Homo sapiens_hsa005900.38154607
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37518054
131Adherens junction_Homo sapiens_hsa045200.37470472
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37327274
133Vitamin digestion and absorption_Homo sapiens_hsa049770.34902441
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33913454
135Lysine degradation_Homo sapiens_hsa003100.30793436
136Ether lipid metabolism_Homo sapiens_hsa005650.29080274
137Regulation of autophagy_Homo sapiens_hsa041400.28060264
138Glycerolipid metabolism_Homo sapiens_hsa005610.25852578
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24143585
140Pentose phosphate pathway_Homo sapiens_hsa000300.23015958

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