NQO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1xenobiotic catabolic process (GO:0042178)5.79046437
2regulation of superoxide anion generation (GO:0032928)5.69893858
3L-ascorbic acid metabolic process (GO:0019852)5.48046021
4glutathione derivative metabolic process (GO:1901685)5.40240718
5glutathione derivative biosynthetic process (GO:1901687)5.40240718
6regulation of skeletal muscle contraction (GO:0014819)5.27388488
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.02043613
8regulation of early endosome to late endosome transport (GO:2000641)4.85196877
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.72124152
10melanosome organization (GO:0032438)4.62571623
11glucuronate metabolic process (GO:0019585)4.56105151
12uronic acid metabolic process (GO:0006063)4.56105151
13negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.53639515
14cellular glucuronidation (GO:0052695)4.49810023
15cellular response to arsenic-containing substance (GO:0071243)4.49063813
16phenol-containing compound biosynthetic process (GO:0046189)4.39101407
17mitotic sister chromatid segregation (GO:0000070)4.38828268
18pigment granule organization (GO:0048753)4.31719674
19negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.29870000
20one-carbon compound transport (GO:0019755)4.22474521
21secondary metabolic process (GO:0019748)4.17887952
22pigment biosynthetic process (GO:0046148)4.13602969
23regulation of superoxide metabolic process (GO:0090322)4.09839069
24response to nitrosative stress (GO:0051409)4.07108422
25cullin deneddylation (GO:0010388)3.95757785
26proteasome assembly (GO:0043248)3.94946219
27sister chromatid segregation (GO:0000819)3.94148867
28pigment cell differentiation (GO:0050931)3.91653849
29melanocyte differentiation (GO:0030318)3.86747711
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.85556484
31maintenance of gastrointestinal epithelium (GO:0030277)3.81019527
32renal absorption (GO:0070293)3.78010081
33nucleobase-containing small molecule interconversion (GO:0015949)3.76539123
34polyketide metabolic process (GO:0030638)3.72075532
35doxorubicin metabolic process (GO:0044598)3.72075532
36daunorubicin metabolic process (GO:0044597)3.72075532
37ethanol oxidation (GO:0006069)3.65114236
38epoxygenase P450 pathway (GO:0019373)3.61074074
39aldehyde catabolic process (GO:0046185)3.59066098
40protein deneddylation (GO:0000338)3.57604576
41pentose-phosphate shunt (GO:0006098)3.57375973
42regulation of mitotic spindle organization (GO:0060236)3.51036693
43negative regulation of meiosis (GO:0045835)3.50418736
44pigment metabolic process (GO:0042440)3.48686808
45glutathione metabolic process (GO:0006749)3.41391582
46ventricular cardiac muscle cell development (GO:0055015)3.40679309
47cysteine metabolic process (GO:0006534)3.40511440
48hemidesmosome assembly (GO:0031581)3.36720348
49regulation of meiosis I (GO:0060631)3.29452199
50negative regulation of acute inflammatory response (GO:0002674)3.28581405
51aminoglycoside antibiotic metabolic process (GO:0030647)3.27475879
52endosome to pigment granule transport (GO:0043485)3.25208118
53endosome to melanosome transport (GO:0035646)3.25208118
54lysine metabolic process (GO:0006553)3.20846694
55lysine catabolic process (GO:0006554)3.20846694
56barbed-end actin filament capping (GO:0051016)3.18738887
57mitotic G1 DNA damage checkpoint (GO:0031571)3.16948567
584-hydroxyproline metabolic process (GO:0019471)3.15711453
59positive regulation of DNA-dependent DNA replication (GO:2000105)3.13366928
60negative regulation of interleukin-1 beta production (GO:0032691)3.11467921
61glucose catabolic process (GO:0006007)3.09524352
62negative regulation of organelle assembly (GO:1902116)3.07736826
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.07133122
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06607163
65desmosome organization (GO:0002934)3.05855306
66sulfation (GO:0051923)3.05226518
67negative regulation of chemokine production (GO:0032682)3.05082185
68response to arsenic-containing substance (GO:0046685)3.00587511
69low-density lipoprotein particle clearance (GO:0034383)2.97649051
70mitotic chromosome condensation (GO:0007076)2.96746742
71negative regulation of receptor-mediated endocytosis (GO:0048261)2.95644561
72hydrogen peroxide catabolic process (GO:0042744)2.93129793
73protein maturation by protein folding (GO:0022417)2.92518652
74epithelial cell-cell adhesion (GO:0090136)2.91447828
75regulation of spindle organization (GO:0090224)2.89089921
76blastocyst development (GO:0001824)2.87498839
77sulfur amino acid catabolic process (GO:0000098)2.86335428
78ribosome assembly (GO:0042255)2.85611014
79ADP metabolic process (GO:0046031)2.85242137
80AMP metabolic process (GO:0046033)2.84793042
81carnitine metabolic process (GO:0009437)2.83983773
82hydrogen peroxide biosynthetic process (GO:0050665)2.83431020
83purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.82726876
843-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.82726876
85regulation of integrin-mediated signaling pathway (GO:2001044)2.82015185
86positive regulation of receptor recycling (GO:0001921)2.81434070
87negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.80067352
88myeloid cell homeostasis (GO:0002262)2.79024737
89tyrosine metabolic process (GO:0006570)2.79007844
90establishment of chromosome localization (GO:0051303)2.78122903
91folic acid transport (GO:0015884)2.77886194
92regulation of chromosome segregation (GO:0051983)2.77488701
93flavonoid metabolic process (GO:0009812)2.76752513
94regulation of tight junction assembly (GO:2000810)2.73924392
95peptidyl-proline hydroxylation (GO:0019511)2.73453730
96mitotic G1/S transition checkpoint (GO:0044819)2.72764622
97protein retention in ER lumen (GO:0006621)2.72378458
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72067249
99phosphorylated carbohydrate dephosphorylation (GO:0046838)2.71213519
100inositol phosphate dephosphorylation (GO:0046855)2.71213519
101ethanol metabolic process (GO:0006067)2.71021221
102tricarboxylic acid cycle (GO:0006099)2.70851213
103intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70160347
104signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70160347
105regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.69839543
106centrosome duplication (GO:0051298)2.69797494
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69472324
108nuclear pore complex assembly (GO:0051292)2.67448830
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67295972
110pentose metabolic process (GO:0019321)2.66937742
111protein localization to endosome (GO:0036010)2.66291702
112spindle assembly involved in mitosis (GO:0090307)2.66143338
113ketone body metabolic process (GO:1902224)2.65351427
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64913529
115protein hydroxylation (GO:0018126)2.64151171
116hepatocyte apoptotic process (GO:0097284)2.64064541
117pyrimidine-containing compound salvage (GO:0008655)2.63892546
118pyrimidine nucleoside salvage (GO:0043097)2.63892546
119signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63341548
120signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63341548
121signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63341548
122gas transport (GO:0015669)2.62890421
123epithelial structure maintenance (GO:0010669)2.62455906
124developmental pigmentation (GO:0048066)2.61831324
125nucleotide-sugar biosynthetic process (GO:0009226)2.61259834
126signal transduction involved in DNA damage checkpoint (GO:0072422)2.60938371
127signal transduction involved in DNA integrity checkpoint (GO:0072401)2.60938371
128valine metabolic process (GO:0006573)2.60710970
129Golgi transport vesicle coating (GO:0048200)2.59537749
130COPI coating of Golgi vesicle (GO:0048205)2.59537749
131mitotic metaphase plate congression (GO:0007080)2.59054804
132G1 DNA damage checkpoint (GO:0044783)2.57675996
133regulation of membrane protein ectodomain proteolysis (GO:0051043)2.57212997
134fibril organization (GO:0097435)2.55543718
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55443031
136sister chromatid cohesion (GO:0007062)2.55277297
137cellular response to nutrient (GO:0031670)2.54971883
138negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.54951906
139negative regulation of ligase activity (GO:0051352)2.54951906
140peptide catabolic process (GO:0043171)2.54785024
141signal transduction involved in cell cycle checkpoint (GO:0072395)2.53024227
142negative regulation of JUN kinase activity (GO:0043508)2.52700092
143regulation of proton transport (GO:0010155)2.52389266
144negative regulation of response to reactive oxygen species (GO:1901032)2.51949011
145inositol phosphate catabolic process (GO:0071545)2.51473317
146hydrogen peroxide metabolic process (GO:0042743)2.51081857
147regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.50018281
148negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.50006672
149spindle checkpoint (GO:0031577)2.49695943
150cellular aldehyde metabolic process (GO:0006081)2.47556747
151tricarboxylic acid metabolic process (GO:0072350)2.46872202
152regulation of translational termination (GO:0006449)2.46356602
153regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.45450248
154mitotic sister chromatid cohesion (GO:0007064)2.44655594
155* xenobiotic metabolic process (GO:0006805)2.43088400
156regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.41138258
157sarcomere organization (GO:0045214)2.36978793
158fatty acid beta-oxidation (GO:0006635)2.35202183
159primary alcohol catabolic process (GO:0034310)2.32520544
160apoptotic process involved in morphogenesis (GO:0060561)2.32337585
161hyperosmotic salinity response (GO:0042538)2.32053309
162positive regulation of extracellular matrix organization (GO:1903055)2.31925467
163wound healing, spreading of epidermal cells (GO:0035313)2.31871987
164lipid oxidation (GO:0034440)2.31450873
165fatty acid oxidation (GO:0019395)2.30765109
166positive regulation of endothelial cell apoptotic process (GO:2000353)2.29263551
167nucleoside diphosphate biosynthetic process (GO:0009133)2.29095909
168negative regulation of chondrocyte differentiation (GO:0032331)2.28801792
169amino-acid betaine metabolic process (GO:0006577)2.28184768
170reactive oxygen species biosynthetic process (GO:1903409)2.27901133
171membrane budding (GO:0006900)2.27349148
172protein autoprocessing (GO:0016540)2.26325266
173cellular response to vitamin (GO:0071295)2.25520472
174branched-chain amino acid catabolic process (GO:0009083)2.25242580
1752-oxoglutarate metabolic process (GO:0006103)2.25206169
176regulation of cholesterol biosynthetic process (GO:0045540)2.25158827
177ventricular cardiac muscle cell action potential (GO:0086005)2.23951587
178branched-chain amino acid metabolic process (GO:0009081)2.23909021
179response to growth hormone (GO:0060416)2.22803303
180cell adhesion mediated by integrin (GO:0033627)2.22387263
181positive regulation of fatty acid biosynthetic process (GO:0045723)2.22070452
182gap junction assembly (GO:0016264)2.21959482
183hormone catabolic process (GO:0042447)2.21571732
184regulation of hippo signaling (GO:0035330)2.21462053
185NADPH regeneration (GO:0006740)2.21445750
186positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21231125
187NADP metabolic process (GO:0006739)2.20256337
188type B pancreatic cell proliferation (GO:0044342)2.20219620
189melanin biosynthetic process (GO:0042438)12.6136713
190melanin metabolic process (GO:0006582)11.3823893
191secondary metabolite biosynthetic process (GO:0044550)10.5294521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.19309116
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.20681198
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.73314554
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.35590220
5RARG_19884340_ChIP-ChIP_MEFs_Mouse4.30087612
6TRIM28_21343339_ChIP-Seq_HEK293_Human4.07130607
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.80454005
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71964678
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.33721852
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19208797
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80851241
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.78378790
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50680736
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48798155
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.46726269
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.43668410
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29934414
18CLOCK_20551151_ChIP-Seq_293T_Human2.28629123
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.27655833
20* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26422423
21STAT3_1855785_ChIP-Seq_MESCs_Mouse2.25824795
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.24985646
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20096975
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.19970769
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17770785
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17078776
27DCP1A_22483619_ChIP-Seq_HELA_Human2.12370773
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.10121805
29* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.07963467
30* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.07762411
31HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05637456
32* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.94054684
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93092877
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.90805521
35TFEB_21752829_ChIP-Seq_HELA_Human1.89829928
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85109868
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.84703092
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83048594
39ELK1_19687146_ChIP-ChIP_HELA_Human1.81129344
40AR_21909140_ChIP-Seq_LNCAP_Human1.80584189
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.78767912
42LXR_22158963_ChIP-Seq_LIVER_Mouse1.76788905
43ZNF263_19887448_ChIP-Seq_K562_Human1.74978637
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73353099
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73257256
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71376966
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71299897
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68921410
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66643203
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63629773
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63629773
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61072892
53* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61054778
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60922813
55ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.60820053
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59620915
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59413867
58SOX2_20726797_ChIP-Seq_SW620_Human1.57719540
59GABP_19822575_ChIP-Seq_HepG2_Human1.57701080
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57355301
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56079790
62ATF3_27146783_Chip-Seq_COLON_Human1.55738243
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51230898
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.51153864
65* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50567758
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50147107
67* GATA4_25053715_ChIP-Seq_YYC3_Human1.49418734
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48654521
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47502342
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.46118880
71* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45425424
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44956163
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.43031023
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.40479564
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39386309
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38783273
77* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37594214
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35458554
79* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.35157844
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.34945132
81* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32764136
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32689269
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31676642
84* RACK7_27058665_Chip-Seq_MCF-7_Human1.30765690
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28768636
86P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27423690
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26535996
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26240431
89* GATA6_25053715_ChIP-Seq_YYC3_Human1.25763319
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23289673
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21233611
92* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19281319
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18678808
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18372223
95* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17459519
96NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14874776
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13273712
98* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12702625
99* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12702625
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.11878796
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10172475
102* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09599192
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08706357
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08554082
105MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08010418
106* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07911392
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07878605
108ELF5_23300383_ChIP-Seq_T47D_Human1.07507327
109* CJUN_26792858_Chip-Seq_BT549_Human1.06924813
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06395040
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05614672
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04555362
113* GATA3_24758297_ChIP-Seq_MCF-7_Human1.04189403
114ELK3_25401928_ChIP-Seq_HUVEC_Human1.03892071
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03708186
116ELK1_22589737_ChIP-Seq_MCF10A_Human1.03522651
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01835041
118FOXO3_23340844_ChIP-Seq_DLD1_Human1.01626863
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01414424
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00911655
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00139685
122BRD4_25478319_ChIP-Seq_HGPS_Human1.00117541
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99244561
124CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98276979
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94779887
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94779887
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94779887
128NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94009327
129XRN2_22483619_ChIP-Seq_HELA_Human0.93981839
130TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93977918
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.91360061
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.91360061
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90676657
134KDM5A_27292631_Chip-Seq_BREAST_Human0.90501639
135TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89671262
136* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89650722
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89084508
138CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88726653
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88143267
140BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87570546
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86903413
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86818014
143UBF1/2_26484160_Chip-Seq_HMECs_Human0.86626867
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86417401
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.84342105
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84241880
147CDX2_20551321_ChIP-Seq_CACO-2_Human0.84234735
148MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83305782
149SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82049281
150TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81750460
151HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81293771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation7.99421876
2MP0008004_abnormal_stomach_pH6.22255430
3MP0005171_absent_coat_pigmentation5.77212762
4MP0003136_yellow_coat_color5.11289016
5MP0000015_abnormal_ear_pigmentation4.41933242
6MP0003705_abnormal_hypodermis_morpholog3.92404167
7MP0005075_abnormal_melanosome_morpholog3.74766997
8MP0000371_diluted_coat_color3.26000241
9MP0002877_abnormal_melanocyte_morpholog3.16568038
10MP0005257_abnormal_intraocular_pressure3.05649958
11* MP0003806_abnormal_nucleotide_metabolis2.97588765
12* MP0003186_abnormal_redox_activity2.80286119
13MP0004381_abnormal_hair_follicle2.71898506
14MP0002095_abnormal_skin_pigmentation2.61157884
15MP0002938_white_spotting2.48298568
16MP0008438_abnormal_cutaneous_collagen2.43056834
17MP0010352_gastrointestinal_tract_polyps2.36443713
18MP0003566_abnormal_cell_adhesion2.18556734
19MP0005174_abnormal_tail_pigmentation2.14920152
20MP0001324_abnormal_eye_pigmentation2.12069483
21MP0005083_abnormal_biliary_tract2.09629773
22MP0003279_aneurysm2.08404646
23MP0008875_abnormal_xenobiotic_pharmacok2.03575301
24MP0002075_abnormal_coat/hair_pigmentati1.98981216
25MP0005360_urolithiasis1.95297170
26MP0001186_pigmentation_phenotype1.92259474
27MP0002102_abnormal_ear_morphology1.91962388
28MP0002254_reproductive_system_inflammat1.90310811
29MP0009384_cardiac_valve_regurgitation1.89957904
30MP0000569_abnormal_digit_pigmentation1.85692595
31MP0002139_abnormal_hepatobiliary_system1.85271503
32MP0005275_abnormal_skin_tensile1.80293894
33MP0010094_abnormal_chromosome_stability1.78010383
34MP0005085_abnormal_gallbladder_physiolo1.74065644
35MP0001873_stomach_inflammation1.70786973
36MP0005023_abnormal_wound_healing1.69159925
37MP0010030_abnormal_orbit_morphology1.67144466
38MP0003878_abnormal_ear_physiology1.66305602
39MP0005377_hearing/vestibular/ear_phenot1.66305602
40MP0001958_emphysema1.54203998
41MP0005197_abnormal_uvea_morphology1.50394686
42MP0003077_abnormal_cell_cycle1.48347120
43MP0005165_increased_susceptibility_to1.47884514
44MP0005409_darkened_coat_color1.45590442
45MP0009840_abnormal_foam_cell1.45442962
46MP0005365_abnormal_bile_salt1.45209404
47MP0000470_abnormal_stomach_morphology1.44420249
48MP0004957_abnormal_blastocyst_morpholog1.42577974
49MP0003111_abnormal_nucleus_morphology1.42513011
50MP0004084_abnormal_cardiac_muscle1.41445127
51MP0000343_altered_response_to1.39310819
52MP0002090_abnormal_vision1.37209236
53MP0001849_ear_inflammation1.31739083
54MP0000750_abnormal_muscle_regeneration1.31072578
55MP0003195_calcinosis1.27201328
56MP0003941_abnormal_skin_development1.26199315
57MP0005332_abnormal_amino_acid1.26084527
58MP0002060_abnormal_skin_morphology1.23843998
59MP0003453_abnormal_keratinocyte_physiol1.21207579
60MP0006054_spinal_hemorrhage1.18772823
61MP0002837_dystrophic_cardiac_calcinosis1.17995830
62MP0009643_abnormal_urine_homeostasis1.16935570
63MP0004019_abnormal_vitamin_homeostasis1.13222114
64MP0000858_altered_metastatic_potential1.10936984
65MP0010368_abnormal_lymphatic_system1.10749626
66MP0008932_abnormal_embryonic_tissue1.07363415
67MP0009780_abnormal_chondrocyte_physiolo1.07014171
68MP0010234_abnormal_vibrissa_follicle1.05474535
69MP0004233_abnormal_muscle_weight1.04395927
70MP0005319_abnormal_enzyme/_coenzyme1.03855291
71MP0003656_abnormal_erythrocyte_physiolo1.03286392
72MP0002295_abnormal_pulmonary_circulatio1.02887705
73MP0001853_heart_inflammation1.02753256
74MP0008260_abnormal_autophagy1.02515505
75MP0005330_cardiomyopathy0.99362962
76MP0004043_abnormal_pH_regulation0.98582342
77MP0005058_abnormal_lysosome_morphology0.96434667
78MP0001664_abnormal_digestion0.96178400
79MP0000762_abnormal_tongue_morphology0.95862441
80MP0003123_paternal_imprinting0.95241361
81MP0002972_abnormal_cardiac_muscle0.93551652
82MP0005367_renal/urinary_system_phenotyp0.92836674
83MP0000516_abnormal_urinary_system0.92836674
84MP0004272_abnormal_basement_membrane0.92069590
85MP0008057_abnormal_DNA_replication0.91399659
86* MP0005266_abnormal_metabolism0.90362634
87MP0005408_hypopigmentation0.88438584
88MP0000733_abnormal_muscle_development0.88414694
89MP0005193_abnormal_anterior_eye0.87613731
90MP0010630_abnormal_cardiac_muscle0.87514831
91MP0001666_abnormal_nutrient_absorption0.86764196
92MP0008007_abnormal_cellular_replicative0.86467374
93MP0004087_abnormal_muscle_fiber0.86143043
94MP0001243_abnormal_dermal_layer0.83866102
95MP0006138_congestive_heart_failure0.83724920
96MP0009053_abnormal_anal_canal0.82147860
97MP0008789_abnormal_olfactory_epithelium0.81358334
98MP0003091_abnormal_cell_migration0.81156034
99MP0008058_abnormal_DNA_repair0.81140468
100MP0002177_abnormal_outer_ear0.80598386
101MP0001346_abnormal_lacrimal_gland0.80251019
102MP0005248_abnormal_Harderian_gland0.79417268
103MP0000678_abnormal_parathyroid_gland0.79383585
104MP0008775_abnormal_heart_ventricle0.78080731
105MP0003828_pulmonary_edema0.77501034
106MP0003646_muscle_fatigue0.77129042
107MP0002896_abnormal_bone_mineralization0.76987866
108MP0002136_abnormal_kidney_physiology0.76441416
109MP0002138_abnormal_hepatobiliary_system0.76122369
110MP0000749_muscle_degeneration0.75042788
111MP0005623_abnormal_meninges_morphology0.74663759
112MP0001544_abnormal_cardiovascular_syste0.74495851
113MP0005385_cardiovascular_system_phenoty0.74495851
114MP0009697_abnormal_copulation0.73941166
115MP0003075_altered_response_to0.73938113
116MP0005636_abnormal_mineral_homeostasis0.73292902
117MP0000350_abnormal_cell_proliferation0.72555177
118MP0003950_abnormal_plasma_membrane0.71048991
119MP0005503_abnormal_tendon_morphology0.70592819
120MP0000358_abnormal_cell_content/0.69600407
121MP0003718_maternal_effect0.69443430
122MP0009764_decreased_sensitivity_to0.68872759
123MP0002269_muscular_atrophy0.68746786
124MP0003436_decreased_susceptibility_to0.67475400
125MP0001542_abnormal_bone_strength0.67464608
126MP0005076_abnormal_cell_differentiation0.67211235
127MP0010155_abnormal_intestine_physiology0.67006131
128MP0004264_abnormal_extraembryonic_tissu0.66920283
129MP0001697_abnormal_embryo_size0.66189190
130MP0003693_abnormal_embryo_hatching0.65882701
131MP0000490_abnormal_crypts_of0.65556095
132MP0003252_abnormal_bile_duct0.65402877
133MP0002168_other_aberrant_phenotype0.65246031
134MP0001216_abnormal_epidermal_layer0.65077108
135MP0005508_abnormal_skeleton_morphology0.65024752
136MP0001756_abnormal_urination0.64503486
137MP0002092_abnormal_eye_morphology0.63909481
138MP0000477_abnormal_intestine_morphology0.63718570
139MP0005501_abnormal_skin_physiology0.63490172
140MP0001663_abnormal_digestive_system0.62169339
141MP0005397_hematopoietic_system_phenotyp0.62128270
142MP0001545_abnormal_hematopoietic_system0.62128270
143MP0004036_abnormal_muscle_relaxation0.61526796
144MP0006036_abnormal_mitochondrial_physio0.60365561
145MP0010678_abnormal_skin_adnexa0.58457766
146MP0002089_abnormal_postnatal_growth/wei0.55789717
147MP0002080_prenatal_lethality0.55528151
148MP0000627_abnormal_mammary_gland0.55401163
149MP0003943_abnormal_hepatobiliary_system0.53670592
150MP0000427_abnormal_hair_cycle0.52517520
151MP0001672_abnormal_embryogenesis/_devel0.51777943
152MP0005380_embryogenesis_phenotype0.51777943
153* MP0005621_abnormal_cell_physiology0.49597700
154MP0000647_abnormal_sebaceous_gland0.47801849
155MP0000367_abnormal_coat/_hair0.47684746
156* MP0005384_cellular_phenotype0.47618236
157MP0003191_abnormal_cellular_cholesterol0.46754591
158MP0001730_embryonic_growth_arrest0.46716336
159MP0004782_abnormal_surfactant_physiolog0.44139671
160MP0000377_abnormal_hair_follicle0.44051716
161MP0002282_abnormal_trachea_morphology0.43870348
162MP0003786_premature_aging0.42765457
163MP0003890_abnormal_embryonic-extraembry0.42036713
164MP0002160_abnormal_reproductive_system0.42028193
165MP0001851_eye_inflammation0.41629875
166MP0002085_abnormal_embryonic_tissue0.37572940
167MP0000003_abnormal_adipose_tissue0.35535419
168MP0001299_abnormal_eye_distance/0.35305980
169MP0002084_abnormal_developmental_patter0.34780745
170MP0002638_abnormal_pupillary_reflex0.34537015

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the macula (HP:0008059)6.95708355
2Aplasia/Hypoplasia affecting the retina (HP:0008061)6.42993976
3White forelock (HP:0002211)6.34140859
4Ocular albinism (HP:0001107)6.26159538
5Patchy hypopigmentation of hair (HP:0011365)6.25230459
6Aplasia/Hypoplasia of the fovea (HP:0008060)6.09323389
7Hypoplasia of the fovea (HP:0007750)6.09323389
8Right ventricular cardiomyopathy (HP:0011663)5.76846032
9Iris hypopigmentation (HP:0007730)5.52879102
10Abnormality of the fovea (HP:0000493)5.14736452
11Blue irides (HP:0000635)5.11699005
12Abnormal auditory evoked potentials (HP:0006958)5.04813401
13Hypopigmentation of the fundus (HP:0007894)4.90891057
14Generalized hypopigmentation (HP:0007513)3.97713791
15Protrusio acetabuli (HP:0003179)3.94856061
16Cutaneous melanoma (HP:0012056)3.87246267
17Abnormality of the anterior horn cell (HP:0006802)3.79365030
18Degeneration of anterior horn cells (HP:0002398)3.79365030
19Abnormal gallbladder physiology (HP:0012438)3.60430016
20Cholecystitis (HP:0001082)3.60430016
21Distal lower limb muscle weakness (HP:0009053)3.58504340
22Freckling (HP:0001480)3.58395004
23Bilateral sensorineural hearing impairment (HP:0008619)3.33396388
24Albinism (HP:0001022)3.31503553
25Ventricular tachycardia (HP:0004756)3.25071988
26Atrophic scars (HP:0001075)3.20951967
27Increased connective tissue (HP:0009025)3.19884822
28Tongue fasciculations (HP:0001308)3.13092593
29Cervical subluxation (HP:0003308)3.11805730
30Palpitations (HP:0001962)3.09108094
31Heterochromia iridis (HP:0001100)3.04842303
32Premature rupture of membranes (HP:0001788)3.02237884
33Long clavicles (HP:0000890)3.00289693
34Absent frontal sinuses (HP:0002688)2.94484557
35Fibular hypoplasia (HP:0003038)2.90027161
36Abnormality of glycolysis (HP:0004366)2.81621644
37Gout (HP:0001997)2.80035170
38Adrenal hypoplasia (HP:0000835)2.76927605
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.75036602
40Abnormal hemoglobin (HP:0011902)2.74341473
41Flat acetabular roof (HP:0003180)2.69298167
42Premature graying of hair (HP:0002216)2.67478912
43Muscle fibrillation (HP:0010546)2.63502966
44Muscle fiber splitting (HP:0003555)2.61882622
45Abnormality of purine metabolism (HP:0004352)2.61536383
46Vertebral compression fractures (HP:0002953)2.61211958
47Hypoplasia of the iris (HP:0007676)2.59351566
48Aortic aneurysm (HP:0004942)2.56659189
49Congenital sensorineural hearing impairment (HP:0008527)2.55574306
50Hyperglycinuria (HP:0003108)2.55069761
51Abnormal cartilage morphology (HP:0002763)2.54676395
52Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.54457213
53Exercise-induced muscle cramps (HP:0003710)2.53823645
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.50212399
55Hypokinesia (HP:0002375)2.49348281
56Spinal muscular atrophy (HP:0007269)2.47142607
57Facial cleft (HP:0002006)2.45412979
58Ketoacidosis (HP:0001993)2.39642650
59Hyperammonemia (HP:0001987)2.36867937
60Abnormality of the distal phalanges of the toes (HP:0010182)2.36437654
61Hypoglycemic coma (HP:0001325)2.33476511
62Abnormality of proline metabolism (HP:0010907)2.32764892
63Hydroxyprolinuria (HP:0003080)2.32764892
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31745116
65Onycholysis (HP:0001806)2.30620245
66Spinal rigidity (HP:0003306)2.27780540
67Myoglobinuria (HP:0002913)2.27691559
68Rhabdomyolysis (HP:0003201)2.27149541
69Increased purine levels (HP:0004368)2.27032290
70Hyperuricemia (HP:0002149)2.27032290
71Peritonitis (HP:0002586)2.27002487
72Ankle contracture (HP:0006466)2.26785256
73Increased nuchal translucency (HP:0010880)2.20144505
74Nephroblastoma (Wilms tumor) (HP:0002667)2.19360142
75Multiple enchondromatosis (HP:0005701)2.18721216
76Abnormal lung lobation (HP:0002101)2.18529750
77Fragile skin (HP:0001030)2.17879396
78Abnormality of nucleobase metabolism (HP:0010932)2.17484637
79Cupped ribs (HP:0000887)2.15508675
80Proximal tubulopathy (HP:0000114)2.15493264
81Upper limb muscle weakness (HP:0003484)2.13928556
82Abnormality of the left ventricular outflow tract (HP:0011103)2.12955849
83Subaortic stenosis (HP:0001682)2.12955849
84Aplasia/Hypoplasia of the fibula (HP:0006492)2.11878317
85Stillbirth (HP:0003826)2.10267133
86Embryonal renal neoplasm (HP:0011794)2.06253154
87Epidermoid cyst (HP:0200040)2.05987076
88Nausea (HP:0002018)2.04831877
89Abnormality of fatty-acid metabolism (HP:0004359)2.04094465
90Duodenal stenosis (HP:0100867)2.03525413
91Small intestinal stenosis (HP:0012848)2.03525413
92Chromsome breakage (HP:0040012)2.03439407
93Lipoatrophy (HP:0100578)2.03400629
94Difficulty climbing stairs (HP:0003551)2.02598677
95Abnormality of the frontal sinuses (HP:0002687)2.02385535
96Melanoma (HP:0002861)2.00593478
97Cardiovascular calcification (HP:0011915)1.99016335
98Abnormality of serine family amino acid metabolism (HP:0010894)1.96730897
99Abnormality of glycine metabolism (HP:0010895)1.96730897
100Back pain (HP:0003418)1.96391447
101Bowed forearm bones (HP:0003956)1.96052748
102Bowing of the arm (HP:0006488)1.96052748
103Ileus (HP:0002595)1.95191871
104Ulnar bowing (HP:0003031)1.94256514
105Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92840565
106Aortic dissection (HP:0002647)1.90274394
107Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.90221841
108Hypoalphalipoproteinemia (HP:0003233)1.89132344
109Intrahepatic cholestasis (HP:0001406)1.88897904
110Renal tubular acidosis (HP:0001947)1.87267165
111Hyporeflexia of lower limbs (HP:0002600)1.85534960
112Xanthomatosis (HP:0000991)1.85451149
113Increased serum ferritin (HP:0003281)1.84680760
114Generalized amyotrophy (HP:0003700)1.84254655
115Fragile nails (HP:0001808)1.83667176
116Ventricular arrhythmia (HP:0004308)1.83222869
117Axonal loss (HP:0003447)1.82949249
118Osteolytic defects of the hand bones (HP:0009699)1.82922338
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.82922338
120Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82652160
121Vertebral hypoplasia (HP:0008417)1.82652160
122Abnormality of the acetabulum (HP:0003170)1.82409609
123Spastic diplegia (HP:0001264)1.81309041
124Coxa vara (HP:0002812)1.81301274
125Intestinal atresia (HP:0011100)1.80830554
126Dilated cardiomyopathy (HP:0001644)1.80217325
127Renal salt wasting (HP:0000127)1.80152220
128Hypobetalipoproteinemia (HP:0003563)1.79923040
129Radial bowing (HP:0002986)1.79532859
130Generalized aminoaciduria (HP:0002909)1.79042276
131Abnormality of the umbilical cord (HP:0010881)1.78664762
132Ketosis (HP:0001946)1.78551083
133Pustule (HP:0200039)1.78281644
134Bifid tongue (HP:0010297)1.77966004
135Trismus (HP:0000211)1.76679622
136Frequent falls (HP:0002359)1.76148604
137Polycythemia (HP:0001901)1.76031170
138Fused cervical vertebrae (HP:0002949)1.75995833
139Abnormality of transition element cation homeostasis (HP:0011030)1.75718591
140Deviation of the thumb (HP:0009603)1.75484202
141Scapular winging (HP:0003691)1.75424549
142Type 1 muscle fiber predominance (HP:0003803)1.74965169
143Median cleft lip (HP:0000161)1.74659254
144Vascular tortuosity (HP:0004948)1.74568204
145Increased serum pyruvate (HP:0003542)1.74548497
146Proximal placement of thumb (HP:0009623)1.74316942
147Short nail (HP:0001799)1.74288072
148Wormian bones (HP:0002645)1.74242912
149Sudden death (HP:0001699)1.73224214
150Dilatation of the ascending aorta (HP:0005111)1.73174855
151Abnormality of iron homeostasis (HP:0011031)1.72122305
152Neonatal short-limb short stature (HP:0008921)1.71486182
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71431369
154Fasciculations (HP:0002380)1.71395627
155Milia (HP:0001056)1.70927283
156Vascular calcification (HP:0004934)1.70681459
157Fibular aplasia (HP:0002990)1.69809562
158Microglossia (HP:0000171)1.69671303
159Elbow flexion contracture (HP:0002987)1.68606783
160Hyperactive renin-angiotensin system (HP:0000841)1.68114629
161Beaking of vertebral bodies (HP:0004568)1.67739065
162Aneurysm (HP:0002617)1.67671085
163Astigmatism (HP:0000483)1.66649104
164Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.65737687
165Dicarboxylic aciduria (HP:0003215)1.65326632
166Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65326632
167Spastic paraparesis (HP:0002313)1.65246060
168Horizontal nystagmus (HP:0000666)1.65167524
169Limb-girdle muscle atrophy (HP:0003797)1.64640453
170Reticulocytosis (HP:0001923)1.64405552
171Diaphragmatic weakness (HP:0009113)1.64370468
172Prolonged neonatal jaundice (HP:0006579)1.63263617
173Decreased motor nerve conduction velocity (HP:0003431)1.61625218
174Abnormality of the fetal cardiovascular system (HP:0010948)1.60761871
175Abnormal umbilical cord blood vessels (HP:0011403)1.60761871
176Single umbilical artery (HP:0001195)1.60761871
177Selective tooth agenesis (HP:0001592)1.60089851
178Arterial tortuosity (HP:0005116)1.58959301
179Neoplasm of the adrenal gland (HP:0100631)1.58708968
180Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.57133561
181Abnormality of methionine metabolism (HP:0010901)1.57120848
182Bifid uvula (HP:0000193)1.54688039
183Sparse eyelashes (HP:0000653)1.48590577
184Abnormalities of placenta or umbilical cord (HP:0001194)1.48210811
185Generalized hypopigmentation of hair (HP:0011358)1.47628820
186Birth length less than 3rd percentile (HP:0003561)1.47383922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE15.46841197
2ERBB43.43581938
3EPHA23.37971624
4TTN3.07632111
5TRIM282.84014655
6MST42.79374367
7NME22.68670745
8PBK2.52508565
9PIM22.52364433
10TRPM72.45046198
11NEK12.42897089
12TESK12.42722416
13MAP3K32.34820952
14SIK32.30596820
15BMPR22.17227295
16DDR22.14380742
17ERBB32.13294359
18MAP3K122.10753800
19EIF2AK32.07659131
20BCKDK2.01866046
21SCYL21.97739414
22TRIB31.97527624
23STK38L1.87822729
24RIPK11.86457390
25ERN11.75653715
26MAPKAPK31.72569492
27BRSK11.70772285
28LRRK21.68885385
29PKN21.67219137
30NEK21.55184486
31STK101.51050031
32MST1R1.50638037
33PRKCH1.48508799
34ZAK1.46154129
35MARK31.43373543
36PDK31.37709926
37PDK41.37709926
38PLK21.37284044
39PDK21.36484409
40LIMK11.31498755
41MET1.30877229
42PLK31.29141104
43MAP3K111.23737092
44BMPR1B1.23443073
45RPS6KB21.21766518
46TAOK21.19941435
47PTK21.18671099
48LMTK21.16041772
49FRK1.15450013
50CCNB11.14698571
51CDK71.14125871
52STK41.14087684
53PAK31.13790826
54TESK21.12436871
55BRSK21.11698323
56PAK41.10376216
57LATS21.07723842
58MAP3K141.07582421
59BMX1.07578659
60PTK61.05402602
61PIK3CG1.05112893
62RPS6KA41.04840214
63FLT31.03156127
64MAP2K31.02575419
65WNK41.01751249
66MATK1.00654099
67NEK60.98394829
68PRKG20.98364852
69MYLK0.97965609
70FER0.97831036
71ABL20.96560513
72NEK90.95464536
73BCR0.94862824
74MAP3K80.91935921
75TSSK60.91704806
76EIF2AK10.91450806
77PDGFRA0.90556015
78TBK10.89472902
79LATS10.87504866
80MELK0.85989121
81STK30.82169126
82CDK60.78392298
83MAP2K10.78231424
84PIK3CA0.72818914
85IRAK30.72000575
86SIK10.71968560
87EIF2AK20.69710364
88STK240.69681896
89ARAF0.69661011
90EPHB10.68994657
91EPHB20.68046810
92PAK20.64915675
93PRKCI0.63319393
94PIM10.62132801
95ILK0.58602549
96STK390.58442780
97CHEK20.56117177
98PINK10.56105684
99IKBKB0.55843715
100MOS0.55433633
101AURKB0.55124971
102DYRK1B0.54747976
103GRK60.54486714
104SRPK10.54434675
105STK380.52863493
106TTK0.52631590
107TYK20.52272476
108EPHA30.52151993
109GRK50.52053227
110MAPK150.51994360
111ATR0.51809168
112PTK2B0.49839679
113JAK30.47903798
114KDR0.47737385
115PNCK0.46588558
116MAP3K50.44710854
117CLK10.44099747
118ROCK10.42882665
119ERBB20.42650592
120CDC70.42303216
121AKT20.42230587
122PAK10.42064533
123CHUK0.41979595
124MAP2K20.40745434
125MAPKAPK20.40521946
126GSK3A0.39858043
127TAOK10.39692752
128TGFBR20.37533749
129SMG10.36274317
130AURKA0.36189968
131CDK80.35395969
132ACVR1B0.34953653
133OBSCN0.33937925
134TGFBR10.33424713
135BUB10.33123330
136DAPK30.32829650
137PRKD10.32695043
138CAMK2D0.32361923
139KSR10.31478985
140ADRBK10.27948758
141EGFR0.27851658
142PLK10.26764761
143VRK20.26179388
144PRKD30.25430358
145ICK0.25145663
146BRAF0.24931279
147MUSK0.24035662
148FGFR10.23853621
149CDK180.23835467

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.09986540
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.64214196
3Glutathione metabolism_Homo sapiens_hsa004803.58918131
4Chemical carcinogenesis_Homo sapiens_hsa052043.52235573
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.94810270
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92918450
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.42810703
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.39551999
9Mismatch repair_Homo sapiens_hsa034302.32156074
10Fatty acid degradation_Homo sapiens_hsa000712.21829680
11Non-homologous end-joining_Homo sapiens_hsa034502.18343365
12Sulfur metabolism_Homo sapiens_hsa009202.12043443
13Protein export_Homo sapiens_hsa030602.10682896
14Vitamin B6 metabolism_Homo sapiens_hsa007501.95743771
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88040656
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86827984
17DNA replication_Homo sapiens_hsa030301.86683647
18Cell cycle_Homo sapiens_hsa041101.84561163
19Phenylalanine metabolism_Homo sapiens_hsa003601.81789816
20Carbon metabolism_Homo sapiens_hsa012001.65643860
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65599345
22Vibrio cholerae infection_Homo sapiens_hsa051101.60825905
23Propanoate metabolism_Homo sapiens_hsa006401.60642639
24N-Glycan biosynthesis_Homo sapiens_hsa005101.60277850
25Starch and sucrose metabolism_Homo sapiens_hsa005001.54685404
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43047270
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42015181
28beta-Alanine metabolism_Homo sapiens_hsa004101.40724855
29Histidine metabolism_Homo sapiens_hsa003401.37465219
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37277058
31Tryptophan metabolism_Homo sapiens_hsa003801.35977820
32Nucleotide excision repair_Homo sapiens_hsa034201.35909739
33Pyruvate metabolism_Homo sapiens_hsa006201.35646782
34Caffeine metabolism_Homo sapiens_hsa002321.34495391
35Homologous recombination_Homo sapiens_hsa034401.33669284
36Selenocompound metabolism_Homo sapiens_hsa004501.28865637
37Folate biosynthesis_Homo sapiens_hsa007901.25335906
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24379662
39Biosynthesis of amino acids_Homo sapiens_hsa012301.22246692
40RNA transport_Homo sapiens_hsa030131.19281699
41Retinol metabolism_Homo sapiens_hsa008301.18314907
42Fatty acid elongation_Homo sapiens_hsa000621.18003240
43Base excision repair_Homo sapiens_hsa034101.17392705
44Peroxisome_Homo sapiens_hsa041461.12695369
45Fatty acid metabolism_Homo sapiens_hsa012121.12588947
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.11620993
47Galactose metabolism_Homo sapiens_hsa000521.10385525
48Vitamin digestion and absorption_Homo sapiens_hsa049771.08808558
49Mineral absorption_Homo sapiens_hsa049781.07972910
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.06593747
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.04810877
52Sphingolipid metabolism_Homo sapiens_hsa006001.02731476
53Arginine biosynthesis_Homo sapiens_hsa002201.02075441
54Tyrosine metabolism_Homo sapiens_hsa003501.01455945
55Arginine and proline metabolism_Homo sapiens_hsa003301.00597418
56Fanconi anemia pathway_Homo sapiens_hsa034600.99890961
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.96972171
58Prostate cancer_Homo sapiens_hsa052150.96389022
59One carbon pool by folate_Homo sapiens_hsa006700.95232888
60Sulfur relay system_Homo sapiens_hsa041220.92447347
61Proteasome_Homo sapiens_hsa030500.90045621
62Adherens junction_Homo sapiens_hsa045200.90021173
63Butanoate metabolism_Homo sapiens_hsa006500.88955915
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88660227
65Legionellosis_Homo sapiens_hsa051340.86162095
66Nitrogen metabolism_Homo sapiens_hsa009100.85353471
67PPAR signaling pathway_Homo sapiens_hsa033200.84528830
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83411002
69Bladder cancer_Homo sapiens_hsa052190.82256778
70Collecting duct acid secretion_Homo sapiens_hsa049660.81532951
71p53 signaling pathway_Homo sapiens_hsa041150.80994419
72Oxidative phosphorylation_Homo sapiens_hsa001900.79684991
73Pentose phosphate pathway_Homo sapiens_hsa000300.79492864
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79418736
75Steroid biosynthesis_Homo sapiens_hsa001000.79069323
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78400767
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77270832
78Oocyte meiosis_Homo sapiens_hsa041140.77054030
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74808141
80ECM-receptor interaction_Homo sapiens_hsa045120.74124011
81Hippo signaling pathway_Homo sapiens_hsa043900.68534763
82Fructose and mannose metabolism_Homo sapiens_hsa000510.67222682
83Fat digestion and absorption_Homo sapiens_hsa049750.64499563
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.64210198
85Arachidonic acid metabolism_Homo sapiens_hsa005900.63682655
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62288135
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61845114
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.60791455
89Bile secretion_Homo sapiens_hsa049760.60197426
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59205814
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.59126044
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54465021
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54368535
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53461207
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53163655
96Other glycan degradation_Homo sapiens_hsa005110.51720331
97Focal adhesion_Homo sapiens_hsa045100.51436064
98Viral myocarditis_Homo sapiens_hsa054160.51124198
99Melanogenesis_Homo sapiens_hsa049160.50642465
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50084267
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49997683
102Melanoma_Homo sapiens_hsa052180.49603063
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49512837
104RNA polymerase_Homo sapiens_hsa030200.49047187
105Small cell lung cancer_Homo sapiens_hsa052220.48742178
106Parkinsons disease_Homo sapiens_hsa050120.47655265
107Shigellosis_Homo sapiens_hsa051310.47502493
108Malaria_Homo sapiens_hsa051440.47007254
109Amoebiasis_Homo sapiens_hsa051460.45725374
110Proteoglycans in cancer_Homo sapiens_hsa052050.44479232
111TGF-beta signaling pathway_Homo sapiens_hsa043500.42720926
112Apoptosis_Homo sapiens_hsa042100.42235972
113Alzheimers disease_Homo sapiens_hsa050100.41480078
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40358268
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40106157
116RNA degradation_Homo sapiens_hsa030180.39687637
117Spliceosome_Homo sapiens_hsa030400.39450418
118Purine metabolism_Homo sapiens_hsa002300.38889888
119Metabolic pathways_Homo sapiens_hsa011000.36960453
120Leishmaniasis_Homo sapiens_hsa051400.36435827
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.35550607
122Dilated cardiomyopathy_Homo sapiens_hsa054140.35326138
123Inositol phosphate metabolism_Homo sapiens_hsa005620.34780760
124Tight junction_Homo sapiens_hsa045300.34199009
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32014582
126Huntingtons disease_Homo sapiens_hsa050160.31195329
127TNF signaling pathway_Homo sapiens_hsa046680.31168967
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31042405
129Pyrimidine metabolism_Homo sapiens_hsa002400.30122616
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30079038
131Thyroid cancer_Homo sapiens_hsa052160.28522713
132Protein digestion and absorption_Homo sapiens_hsa049740.27549125
133Lysosome_Homo sapiens_hsa041420.27189918
134Cardiac muscle contraction_Homo sapiens_hsa042600.26882413
135Pathways in cancer_Homo sapiens_hsa052000.26411416

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