NQO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.95571619
2L-phenylalanine catabolic process (GO:0006559)6.95571619
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.70076593
4L-phenylalanine metabolic process (GO:0006558)6.70076593
5aromatic amino acid family catabolic process (GO:0009074)6.49300113
6tryptophan catabolic process (GO:0006569)6.05620806
7indole-containing compound catabolic process (GO:0042436)6.05620806
8indolalkylamine catabolic process (GO:0046218)6.05620806
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.93763328
10kynurenine metabolic process (GO:0070189)5.80897867
11tryptophan metabolic process (GO:0006568)5.72418178
12glyoxylate metabolic process (GO:0046487)5.64213776
13bile acid biosynthetic process (GO:0006699)5.63978486
14alpha-linolenic acid metabolic process (GO:0036109)5.52613145
15urea metabolic process (GO:0019627)5.43115079
16urea cycle (GO:0000050)5.43115079
17peptidyl-glutamic acid carboxylation (GO:0017187)5.40437263
18protein carboxylation (GO:0018214)5.40437263
19high-density lipoprotein particle remodeling (GO:0034375)5.21248316
20cysteine metabolic process (GO:0006534)5.16338491
21negative regulation of fibrinolysis (GO:0051918)5.12001203
22complement activation, alternative pathway (GO:0006957)5.08772945
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04991933
24sulfur amino acid catabolic process (GO:0000098)5.00560099
25regulation of protein activation cascade (GO:2000257)5.00428066
26nitrogen cycle metabolic process (GO:0071941)4.99293848
27regulation of fibrinolysis (GO:0051917)4.85874672
28serine family amino acid catabolic process (GO:0009071)4.81992722
29bile acid metabolic process (GO:0008206)4.75582271
30lysine catabolic process (GO:0006554)4.73754318
31lysine metabolic process (GO:0006553)4.73754318
32homocysteine metabolic process (GO:0050667)4.73539394
33aromatic amino acid family metabolic process (GO:0009072)4.73368868
34regulation of complement activation (GO:0030449)4.70383270
35regulation of triglyceride catabolic process (GO:0010896)4.63024705
36amino-acid betaine metabolic process (GO:0006577)4.59273497
37protein-lipid complex remodeling (GO:0034368)4.55018323
38macromolecular complex remodeling (GO:0034367)4.55018323
39plasma lipoprotein particle remodeling (GO:0034369)4.55018323
40regulation of cholesterol esterification (GO:0010872)4.54868952
41reverse cholesterol transport (GO:0043691)4.53373512
42tyrosine metabolic process (GO:0006570)4.47173497
43alpha-amino acid catabolic process (GO:1901606)4.43000849
44phospholipid efflux (GO:0033700)4.32863908
45imidazole-containing compound metabolic process (GO:0052803)4.32400890
46glycine metabolic process (GO:0006544)4.30833865
47acylglycerol homeostasis (GO:0055090)4.30828805
48triglyceride homeostasis (GO:0070328)4.30828805
49indolalkylamine metabolic process (GO:0006586)4.29377649
50plasma lipoprotein particle clearance (GO:0034381)4.29011611
51cellular ketone body metabolic process (GO:0046950)4.27974354
52amine catabolic process (GO:0009310)4.25664430
53cellular biogenic amine catabolic process (GO:0042402)4.25664430
54ethanol oxidation (GO:0006069)4.23594629
55aldehyde catabolic process (GO:0046185)4.22592538
56bile acid and bile salt transport (GO:0015721)4.21245396
57negative regulation of sterol transport (GO:0032372)4.16128556
58negative regulation of cholesterol transport (GO:0032375)4.16128556
59cellular glucuronidation (GO:0052695)4.12560828
60cellular amino acid catabolic process (GO:0009063)4.05545161
61serine family amino acid metabolic process (GO:0009069)4.04033963
62benzene-containing compound metabolic process (GO:0042537)4.02243889
63low-density lipoprotein particle remodeling (GO:0034374)4.01593839
64coenzyme catabolic process (GO:0009109)4.01108351
65cholesterol efflux (GO:0033344)3.98367496
66fibrinolysis (GO:0042730)3.87749753
67plasma lipoprotein particle assembly (GO:0034377)3.84808653
68serine family amino acid biosynthetic process (GO:0009070)3.84574819
69cellular response to ATP (GO:0071318)3.78437289
70arginine metabolic process (GO:0006525)3.77391239
71cellular modified amino acid catabolic process (GO:0042219)3.73785501
72glutamate metabolic process (GO:0006536)3.72993396
73uronic acid metabolic process (GO:0006063)3.71586432
74glucuronate metabolic process (GO:0019585)3.71586432
75regulation of skeletal muscle contraction (GO:0014819)3.71508693
76ketone body metabolic process (GO:1902224)3.69316516
77cofactor catabolic process (GO:0051187)3.68899548
78very-low-density lipoprotein particle assembly (GO:0034379)3.68028076
79NAD biosynthetic process (GO:0009435)3.67971961
80drug catabolic process (GO:0042737)3.67146764
81blood coagulation, intrinsic pathway (GO:0007597)3.65433375
82nicotinamide nucleotide biosynthetic process (GO:0019359)3.65253116
83pyridine nucleotide biosynthetic process (GO:0019363)3.65253116
84dicarboxylic acid biosynthetic process (GO:0043650)3.64024744
85carboxylic acid catabolic process (GO:0046395)3.62859772
86organic acid catabolic process (GO:0016054)3.62859772
87phospholipid homeostasis (GO:0055091)3.62308923
882-oxoglutarate metabolic process (GO:0006103)3.60265572
89positive regulation of lipid catabolic process (GO:0050996)3.57371611
90protein activation cascade (GO:0072376)3.55356278
91neutrophil activation involved in immune response (GO:0002283)3.54633656
92plasma lipoprotein particle organization (GO:0071827)3.54178210
93short-chain fatty acid metabolic process (GO:0046459)3.53453504
94complement activation (GO:0006956)3.52986025
95positive regulation of lipoprotein lipase activity (GO:0051006)3.52860987
96positive regulation of triglyceride lipase activity (GO:0061365)3.52860987
97carnitine metabolic process (GO:0009437)3.52536251
98complement activation, classical pathway (GO:0006958)3.51687055
99cholesterol homeostasis (GO:0042632)3.50928568
100response to nitrosative stress (GO:0051409)3.48754481
101acetyl-CoA metabolic process (GO:0006084)3.48533284
102purinergic nucleotide receptor signaling pathway (GO:0035590)3.46937954
103sterol homeostasis (GO:0055092)3.46018183
104fatty acid beta-oxidation (GO:0006635)3.43102498
105adenosine receptor signaling pathway (GO:0001973)3.31873028
106respiratory chain complex IV assembly (GO:0008535)3.29129594
107GDP-mannose metabolic process (GO:0019673)3.20971763
108rRNA methylation (GO:0031167)3.11160997
109rRNA modification (GO:0000154)2.95051771
110cytochrome complex assembly (GO:0017004)2.92052852
111leukocyte degranulation (GO:0043299)2.83441344
112mitochondrial respiratory chain complex I assembly (GO:0032981)2.82249516
113NADH dehydrogenase complex assembly (GO:0010257)2.82249516
114mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82249516
115DNA deamination (GO:0045006)2.79741640
116detection of light stimulus involved in sensory perception (GO:0050962)2.76862836
117detection of light stimulus involved in visual perception (GO:0050908)2.76862836
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75962416
119response to ATP (GO:0033198)2.73732453
120purinergic receptor signaling pathway (GO:0035587)2.72258905
121response to peptidoglycan (GO:0032494)2.71935419
122G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.71919171
123cardiolipin metabolic process (GO:0032048)2.69558367
124pyridine-containing compound biosynthetic process (GO:0072525)2.68987021
125pseudouridine synthesis (GO:0001522)2.68908500
126amino acid salvage (GO:0043102)2.68776320
127L-methionine salvage (GO:0071267)2.68776320
128L-methionine biosynthetic process (GO:0071265)2.68776320
129positive regulation of heat generation (GO:0031652)2.63088200
130proteasome assembly (GO:0043248)2.63047094
131methionine biosynthetic process (GO:0009086)2.60019461
132water-soluble vitamin biosynthetic process (GO:0042364)2.56078285
133behavioral response to nicotine (GO:0035095)2.55806065
134DNA replication checkpoint (GO:0000076)2.54472646
135detection of molecule of bacterial origin (GO:0032490)2.50181035
136regulation of mast cell activation (GO:0033003)2.49956484
137regulation of memory T cell differentiation (GO:0043380)2.47535145
138granulocyte activation (GO:0036230)2.47245302
139mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46819696
140ATP synthesis coupled proton transport (GO:0015986)2.45565416
141energy coupled proton transport, down electrochemical gradient (GO:0015985)2.45565416
142protein complex biogenesis (GO:0070271)2.44917944
143superoxide anion generation (GO:0042554)2.44098445
144positive regulation of mast cell activation (GO:0033005)2.41997804
145negative regulation of interleukin-12 production (GO:0032695)2.41718424
146heme transport (GO:0015886)2.41453106
147response to interferon-beta (GO:0035456)2.40610540
148transcription elongation from RNA polymerase III promoter (GO:0006385)2.40166545
149termination of RNA polymerase III transcription (GO:0006386)2.40166545
150neutrophil activation (GO:0042119)2.36219989
151peptidyl-histidine modification (GO:0018202)2.36122452
152S-adenosylmethionine metabolic process (GO:0046500)2.35074925
153myeloid cell activation involved in immune response (GO:0002275)2.34825210
154indole-containing compound metabolic process (GO:0042430)2.32870505
155dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.32867098
156electron transport chain (GO:0022900)2.32596658
157NAD metabolic process (GO:0019674)2.31102152
158negative regulation of interleukin-1 production (GO:0032692)2.30892206
159methionine metabolic process (GO:0006555)2.30477201
160endosome to pigment granule transport (GO:0043485)2.30238573
161endosome to melanosome transport (GO:0035646)2.30238573
162negative regulation of interleukin-1 beta production (GO:0032691)2.29244298
163pantothenate metabolic process (GO:0015939)2.28798361
164hydrogen peroxide biosynthetic process (GO:0050665)2.28754717
165respiratory electron transport chain (GO:0022904)2.28544989
166meiotic chromosome segregation (GO:0045132)2.28372105
167mitochondrial respiratory chain complex assembly (GO:0033108)2.28295602
168sulfation (GO:0051923)2.27499090
169positive regulation of triglyceride biosynthetic process (GO:0010867)2.26977203
170negative regulation of tumor necrosis factor production (GO:0032720)2.26233214
171response to misfolded protein (GO:0051788)2.24987140
172autophagic vacuole fusion (GO:0000046)2.24412075
173leukocyte migration involved in inflammatory response (GO:0002523)2.24155743
174low-density lipoprotein particle clearance (GO:0034383)2.22764202
175oligosaccharide catabolic process (GO:0009313)2.21814243
176regulation of mast cell activation involved in immune response (GO:0033006)2.21278896
177regulation of mast cell degranulation (GO:0043304)2.20736425
178protein neddylation (GO:0045116)2.20688111
179negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.17862490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.72962012
2* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.74917519
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.73245260
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.93379097
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.10016580
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.04214932
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.67165674
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.97347300
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.54628789
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64072067
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55662226
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29534059
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25425377
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24223905
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.18850034
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.02964349
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.02325404
18* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0379158
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94538505
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91967455
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.87721053
22GATA1_22025678_ChIP-Seq_K562_Human1.86630381
23* BCOR_27268052_Chip-Seq_Bcells_Human1.84313481
24VDR_21846776_ChIP-Seq_THP-1_Human1.84018711
25* BCL6_27268052_Chip-Seq_Bcells_Human1.83851377
26SCL_19346495_ChIP-Seq_HPC-7_Human1.75368105
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73306567
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72651284
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70994474
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67379632
31* P68_20966046_ChIP-Seq_HELA_Human1.65833878
32E2F1_20622854_ChIP-Seq_HELA_Human1.65619350
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63873141
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.59707764
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54211350
36VDR_23849224_ChIP-Seq_CD4+_Human1.53484619
37BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51664950
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51139061
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50896409
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.49840474
41SPI1_23547873_ChIP-Seq_NB4_Human1.49156948
42CLOCK_20551151_ChIP-Seq_293T_Human1.47084843
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45587564
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.45548837
45VDR_22108803_ChIP-Seq_LS180_Human1.45029386
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44820050
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44300869
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43804740
49SPI1_23127762_ChIP-Seq_K562_Human1.42053937
50MAF_26560356_Chip-Seq_TH2_Human1.41823582
51PHF8_20622854_ChIP-Seq_HELA_Human1.39776177
52RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39006492
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37859315
54ERA_21632823_ChIP-Seq_H3396_Human1.37804308
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37746531
56* GATA1_19941826_ChIP-Seq_K562_Human1.37361376
57* NANOG_20526341_ChIP-Seq_ESCs_Human1.34233725
58VDR_24763502_ChIP-Seq_THP-1_Human1.34209090
59HTT_18923047_ChIP-ChIP_STHdh_Human1.34128952
60* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34043065
61CTCF_20526341_ChIP-Seq_ESCs_Human1.31514617
62* HNF4A_19822575_ChIP-Seq_HepG2_Human1.31148278
63FOXP3_21729870_ChIP-Seq_TREG_Human1.30353327
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30222049
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.29754987
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27953544
67OCT4_20526341_ChIP-Seq_ESCs_Human1.27450444
68MAF_26560356_Chip-Seq_TH1_Human1.26582141
69TAF2_19829295_ChIP-Seq_ESCs_Human1.26553960
70P300_27268052_Chip-Seq_Bcells_Human1.26019183
71* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25297092
72NCOR1_26117541_ChIP-Seq_K562_Human1.22007347
73P53_21459846_ChIP-Seq_SAOS-2_Human1.20565146
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.19978230
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19803605
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.19677478
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19080975
78MYC_19829295_ChIP-Seq_ESCs_Human1.18730559
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17725780
80* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17420266
81TP53_22573176_ChIP-Seq_HFKS_Human1.16902578
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14845758
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14804499
84SA1_27219007_Chip-Seq_Bcells_Human1.14798958
85RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14769219
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13523102
87* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13461217
88RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13109470
89STAT1_20625510_ChIP-Seq_HELA_Human1.12686159
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12269246
91GABP_19822575_ChIP-Seq_HepG2_Human1.11087522
92IRF8_21731497_ChIP-ChIP_J774_Mouse1.10767225
93GATA3_26560356_Chip-Seq_TH2_Human1.10121118
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.09919548
95DCP1A_22483619_ChIP-Seq_HELA_Human1.09835259
96XRN2_22483619_ChIP-Seq_HELA_Human1.07306393
97* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06885043
98* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06787774
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06591997
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05667889
101UTX_26944678_Chip-Seq_JUKART_Human1.05169247
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04536200
103* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02041670
104IRF8_27001747_Chip-Seq_BMDM_Mouse1.01215922
105* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99397567
106* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99339898
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98979071
108GATA4_25053715_ChIP-Seq_YYC3_Human0.97091696
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93296895
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86845130
111MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85926771
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85083052
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84501323
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84426426
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83754964
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83495286
117* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82455522
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78311862
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72663483
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72663483
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.71409088
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.70399258
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.70019887
124ELF1_17652178_ChIP-ChIP_JURKAT_Human0.68716351
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67689075
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65869306
127* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64896050
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64695415
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.64643322
130PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.64417754
131* SRF_21415370_ChIP-Seq_HL-1_Mouse0.64175652
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.64098888
133AR_20517297_ChIP-Seq_VCAP_Human0.61614136
134* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.60964330
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.60165459
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.58786242
137* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.58430426
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.58205435
139EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.58160283
140* CEBPB_22108803_ChIP-Seq_LS180_Human0.55399217
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.55049219
142AR_21909140_ChIP-Seq_LNCAP_Human0.54975126
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.54480078
144* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.54163754
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.54103788
146ZNF263_19887448_ChIP-Seq_K562_Human0.53877824
147* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.53617691
148EGR1_19032775_ChIP-ChIP_M12_Human0.53356129
149STAT1_17558387_ChIP-Seq_HELA_Human0.52617563
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.52616726
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.51805117
152BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.51685436
153LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.51317118
154GATA6_25053715_ChIP-Seq_YYC3_Human0.50489926
155* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.50367039
156AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.50216523
157PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.48974521
158* RARB_24833708_ChIP-Seq_LIVER_Mouse0.48839862
159* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.48212147
160FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48046880
161PU_27001747_Chip-Seq_BMDM_Mouse0.46941248
162SOX2_20726797_ChIP-Seq_SW620_Human0.46651534
163LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.46451230
164RAD21_21589869_ChIP-Seq_MESCs_Mouse0.45588221
165FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.43693971
166CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.42923633
167FOXA1_25552417_ChIP-Seq_VCAP_Human0.42442925
168* GATA2_19941826_ChIP-Seq_K562_Human0.42213567
169TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.41833443
170ESET_19884257_ChIP-Seq_ESCs_Mouse0.41347482
171SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.40425097
172SPI1_20517297_ChIP-Seq_HL60_Human0.39663196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.79658923
2MP0005360_urolithiasis7.00379838
3MP0005085_abnormal_gallbladder_physiolo5.96040194
4MP0005365_abnormal_bile_salt5.70421381
5MP0008875_abnormal_xenobiotic_pharmacok4.67149847
6MP0003806_abnormal_nucleotide_metabolis4.20964398
7MP0003252_abnormal_bile_duct3.63841637
8MP0010329_abnormal_lipoprotein_level3.33792243
9MP0003136_yellow_coat_color3.27344446
10MP0005083_abnormal_biliary_tract3.11229828
11MP0009840_abnormal_foam_cell2.97897217
12MP0005171_absent_coat_pigmentation2.86836206
13MP0005174_abnormal_tail_pigmentation2.85982186
14MP0001986_abnormal_taste_sensitivity2.64128845
15MP0005332_abnormal_amino_acid2.63261163
16MP0003195_calcinosis2.62459540
17MP0001666_abnormal_nutrient_absorption2.37076670
18MP0004147_increased_porphyrin_level2.35247418
19MP0003191_abnormal_cellular_cholesterol2.32765127
20MP0001968_abnormal_touch/_nociception2.25486464
21MP0003646_muscle_fatigue2.20371240
22MP0000609_abnormal_liver_physiology2.12253004
23MP0002736_abnormal_nociception_after2.10919139
24MP0009697_abnormal_copulation2.01909545
25MP0004019_abnormal_vitamin_homeostasis1.98244683
26MP0002138_abnormal_hepatobiliary_system1.97147296
27MP0005319_abnormal_enzyme/_coenzyme1.95692215
28MP0002118_abnormal_lipid_homeostasis1.92436301
29MP0002148_abnormal_hypersensitivity_rea1.90916795
30MP0001764_abnormal_homeostasis1.79167258
31MP0003186_abnormal_redox_activity1.76398753
32MP0003868_abnormal_feces_composition1.70768472
33MP0000015_abnormal_ear_pigmentation1.68533715
34* MP0005584_abnormal_enzyme/coenzyme_acti1.50000297
35MP0005167_abnormal_blood-brain_barrier1.47754861
36MP0003656_abnormal_erythrocyte_physiolo1.46260529
37MP0009764_decreased_sensitivity_to1.39842719
38MP0003303_peritoneal_inflammation1.32583967
39MP0009643_abnormal_urine_homeostasis1.31692052
40MP0005410_abnormal_fertilization1.29525594
41MP0005423_abnormal_somatic_nervous1.25255474
42MP0000598_abnormal_liver_morphology1.25183415
43MP0005671_abnormal_response_to1.23040431
44MP0005397_hematopoietic_system_phenotyp1.22731086
45MP0001545_abnormal_hematopoietic_system1.22731086
46MP0005451_abnormal_body_composition1.22012516
47MP0005551_abnormal_eye_electrophysiolog1.21320752
48MP0004043_abnormal_pH_regulation1.20575071
49MP0003705_abnormal_hypodermis_morpholog1.20000586
50MP0003011_delayed_dark_adaptation1.19959322
51MP0000372_irregular_coat_pigmentation1.18071716
52MP0009278_abnormal_bone_marrow1.17213034
53MP0008872_abnormal_physiological_respon1.16880890
54MP0002723_abnormal_immune_serum1.16276893
55MP0008469_abnormal_protein_level1.15957730
56MP0009763_increased_sensitivity_to1.15808591
57MP0004381_abnormal_hair_follicle1.14101461
58MP0003436_decreased_susceptibility_to1.12815506
59MP0005647_abnormal_sex_gland1.10068141
60MP0002452_abnormal_antigen_presenting1.07428783
61MP0003878_abnormal_ear_physiology1.06861113
62MP0005377_hearing/vestibular/ear_phenot1.06861113
63MP0003879_abnormal_hair_cell1.06319995
64MP0003724_increased_susceptibility_to1.05421298
65MP0006036_abnormal_mitochondrial_physio1.03646561
66MP0002332_abnormal_exercise_endurance1.01813673
67MP0004510_myositis1.00838124
68MP0010368_abnormal_lymphatic_system1.00299097
69MP0005000_abnormal_immune_tolerance0.98852992
70MP0001800_abnormal_humoral_immune0.96989574
71MP0009046_muscle_twitch0.95169443
72MP0001501_abnormal_sleep_pattern0.93829186
73MP0005464_abnormal_platelet_physiology0.93317271
74MP0005636_abnormal_mineral_homeostasis0.92822777
75MP0005408_hypopigmentation0.92724069
76MP0001819_abnormal_immune_cell0.91208385
77MP0000371_diluted_coat_color0.91008445
78MP0002420_abnormal_adaptive_immunity0.89404551
79MP0000358_abnormal_cell_content/0.88613380
80MP0009642_abnormal_blood_homeostasis0.88168317
81MP0005058_abnormal_lysosome_morphology0.86991061
82MP0000604_amyloidosis0.86763947
83MP0009333_abnormal_splenocyte_physiolog0.86142968
84MP0003137_abnormal_impulse_conducting0.85147064
85MP0005376_homeostasis/metabolism_phenot0.84088624
86MP0005387_immune_system_phenotype0.83567222
87MP0001790_abnormal_immune_system0.83567222
88MP0002638_abnormal_pupillary_reflex0.81937415
89MP0000750_abnormal_muscle_regeneration0.81463272
90MP0002254_reproductive_system_inflammat0.78447484
91MP0009785_altered_susceptibility_to0.78279854
92MP0002876_abnormal_thyroid_physiology0.77549326
93MP0001853_heart_inflammation0.77181538
94MP0000569_abnormal_digit_pigmentation0.77058224
95MP0000689_abnormal_spleen_morphology0.77010523
96MP0005670_abnormal_white_adipose0.76710376
97MP0000230_abnormal_systemic_arterial0.76361562
98MP0004782_abnormal_surfactant_physiolog0.76327598
99MP0002064_seizures0.76206218
100MP0001970_abnormal_pain_threshold0.75475614
101MP0004142_abnormal_muscle_tone0.75455945
102MP0004130_abnormal_muscle_cell0.75445294
103MP0009765_abnormal_xenobiotic_induced0.73504330
104MP0005084_abnormal_gallbladder_morpholo0.73403059
105MP0002078_abnormal_glucose_homeostasis0.70928819
106MP0005334_abnormal_fat_pad0.70322070
107MP0005220_abnormal_exocrine_pancreas0.68905906
108MP0002419_abnormal_innate_immunity0.67826765
109MP0001756_abnormal_urination0.67674632
110MP0005266_abnormal_metabolism0.67527069
111MP0002971_abnormal_brown_adipose0.67020593
112MP0001835_abnormal_antigen_presentation0.65122878
113MP0001845_abnormal_inflammatory_respons0.63178759
114MP0006035_abnormal_mitochondrial_morpho0.63087956
115MP0001661_extended_life_span0.62319919
116MP0005025_abnormal_response_to0.60363163
117MP0006082_CNS_inflammation0.56289444
118MP0002136_abnormal_kidney_physiology0.56255654
119MP0009053_abnormal_anal_canal0.55728165
120MP0003690_abnormal_glial_cell0.54982215
121MP0005535_abnormal_body_temperature0.54688987
122MP0008873_increased_physiological_sensi0.52444435
123MP0003300_gastrointestinal_ulcer0.49683389
124MP0000249_abnormal_blood_vessel0.49352588
125MP0005166_decreased_susceptibility_to0.48454282
126MP0002132_abnormal_respiratory_system0.47680343
127MP0005395_other_phenotype0.46342235
128MP0001533_abnormal_skeleton_physiology0.46130512
129MP0003638_abnormal_response/metabolism_0.44038425
130MP0000639_abnormal_adrenal_gland0.43859301
131MP0005448_abnormal_energy_balance0.43725748
132MP0002928_abnormal_bile_duct0.43706906
133MP0009115_abnormal_fat_cell0.43066940
134MP0003075_altered_response_to0.41504674
135MP0001881_abnormal_mammary_gland0.38608589
136MP0003172_abnormal_lysosome_physiology0.38120466
137MP0003718_maternal_effect0.37667253
138MP0008874_decreased_physiological_sensi0.37287912
139MP0004883_abnormal_blood_vessel0.36595592
140MP0000343_altered_response_to0.36539259
141MP0002168_other_aberrant_phenotype0.36399296
142MP0001243_abnormal_dermal_layer0.36094845
143MP0005164_abnormal_response_to0.36025845
144MP0010155_abnormal_intestine_physiology0.35577049
145MP0005666_abnormal_adipose_tissue0.35268095
146MP0000685_abnormal_immune_system0.35087829
147MP0005023_abnormal_wound_healing0.34716122
148MP0002970_abnormal_white_adipose0.34321715
149MP0002837_dystrophic_cardiac_calcinosis0.33562757
150MP0002135_abnormal_kidney_morphology0.32810073

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.75590368
2Intrahepatic cholestasis (HP:0001406)6.73258669
3Deep venous thrombosis (HP:0002625)6.59217488
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.21007215
5Prolonged partial thromboplastin time (HP:0003645)6.17555034
6Hypobetalipoproteinemia (HP:0003563)5.99142118
7Xanthomatosis (HP:0000991)5.64384751
8Joint hemorrhage (HP:0005261)4.94063236
9Hyperlipoproteinemia (HP:0010980)4.94046189
10Complement deficiency (HP:0004431)4.88111587
11Hyperammonemia (HP:0001987)4.46388173
12Hypolipoproteinemia (HP:0010981)4.46229407
13Abnormality of the common coagulation pathway (HP:0010990)4.36293630
14Hyperglycinemia (HP:0002154)4.12818914
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12607015
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.10198726
17Epidermoid cyst (HP:0200040)4.08223499
18Abnormality of methionine metabolism (HP:0010901)4.06646678
19Ketosis (HP:0001946)3.99456155
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.97630375
21Hypoglycemic coma (HP:0001325)3.95527937
22Fat malabsorption (HP:0002630)3.91967341
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.90595338
24Abnormality of pyrimidine metabolism (HP:0004353)3.87728618
25Hyperglycinuria (HP:0003108)3.87413946
26Abnormality of the intrinsic pathway (HP:0010989)3.86979860
27Hypoalphalipoproteinemia (HP:0003233)3.82113811
28Abnormality of glycine metabolism (HP:0010895)3.75288936
29Abnormality of serine family amino acid metabolism (HP:0010894)3.75288936
30Abnormality of complement system (HP:0005339)3.71332553
31Congenital stationary night blindness (HP:0007642)3.67243955
32Abnormality of fatty-acid metabolism (HP:0004359)3.59299949
33Abnormality of alanine metabolism (HP:0010916)3.58998017
34Hyperalaninemia (HP:0003348)3.58998017
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.58998017
36Conjugated hyperbilirubinemia (HP:0002908)3.54905195
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.47516856
38Hypercholesterolemia (HP:0003124)3.45131879
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44842041
40Attenuation of retinal blood vessels (HP:0007843)3.42792900
41Increased cerebral lipofuscin (HP:0011813)3.36458029
42Hyperbilirubinemia (HP:0002904)3.32231318
43Decreased electroretinogram (ERG) amplitude (HP:0000654)3.16604170
44Recurrent gram-negative bacterial infections (HP:0005420)3.15396270
45Systemic lupus erythematosus (HP:0002725)3.10944239
46Abnormality of nucleobase metabolism (HP:0010932)3.07283763
47Steatorrhea (HP:0002570)3.02880951
48Abnormality of serum amino acid levels (HP:0003112)3.01855237
49Ketoacidosis (HP:0001993)2.94832393
50Myocardial infarction (HP:0001658)2.92453726
51Hepatocellular carcinoma (HP:0001402)2.87500268
52Petechiae (HP:0000967)2.87106682
53Delayed CNS myelination (HP:0002188)2.87079945
54Dyschromatopsia (HP:0007641)2.84755800
55Facial diplegia (HP:0001349)2.83670575
56Dicarboxylic aciduria (HP:0003215)2.82275364
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82275364
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80696161
59Hypochromic microcytic anemia (HP:0004840)2.78585960
60Abnormality of liposaccharide metabolism (HP:0010968)2.76856221
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.76856221
62Abnormality of glycolipid metabolism (HP:0010969)2.76856221
63Metabolic acidosis (HP:0001942)2.75439565
64Renal Fanconi syndrome (HP:0001994)2.71591830
65Decreased central vision (HP:0007663)2.67797632
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.67196442
67Abnormality of purine metabolism (HP:0004352)2.67061336
68Stomatitis (HP:0010280)2.66818625
69Glomerulonephritis (HP:0000099)2.65931529
70Skin nodule (HP:0200036)2.65838322
71Increased CSF lactate (HP:0002490)2.65160797
72Birth length less than 3rd percentile (HP:0003561)2.62786909
73Type I transferrin isoform profile (HP:0003642)2.61972913
74Lethargy (HP:0001254)2.60044059
75Mitochondrial inheritance (HP:0001427)2.56210092
76Lipid accumulation in hepatocytes (HP:0006561)2.54302404
77Cerebral edema (HP:0002181)2.50556953
78Vascular calcification (HP:0004934)2.48404019
79Acute encephalopathy (HP:0006846)2.42902025
80Generalized aminoaciduria (HP:0002909)2.42872245
81Acute necrotizing encephalopathy (HP:0006965)2.42490571
82Testicular atrophy (HP:0000029)2.39079025
83Acanthocytosis (HP:0001927)2.38494148
84Anorexia (HP:0002039)2.37649807
85Spontaneous abortion (HP:0005268)2.37205681
86Increased hepatocellular lipid droplets (HP:0006565)2.35775751
87Mitral stenosis (HP:0001718)2.35653108
88Hepatocellular necrosis (HP:0001404)2.35628335
89Spastic diplegia (HP:0001264)2.34170918
90Abnormality of the heme biosynthetic pathway (HP:0010472)2.34043484
91Prolonged bleeding time (HP:0003010)2.33797973
92Vacuolated lymphocytes (HP:0001922)2.32504372
93Gingival bleeding (HP:0000225)2.31995758
94Renal cortical cysts (HP:0000803)2.31785903
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29624626
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29262546
97Abnormal protein N-linked glycosylation (HP:0012347)2.29262546
98Abnormal protein glycosylation (HP:0012346)2.29262546
99Abnormal glycosylation (HP:0012345)2.29262546
100Orchitis (HP:0100796)2.28566358
101Menorrhagia (HP:0000132)2.27602030
102Hepatic necrosis (HP:0002605)2.27079259
103Esophageal varix (HP:0002040)2.26754801
104Myositis (HP:0100614)2.26622234
105Nausea (HP:0002018)2.26264620
106Increased muscle lipid content (HP:0009058)2.25029036
107Cardiovascular calcification (HP:0011915)2.24763238
108Abnormal gallbladder morphology (HP:0012437)2.24517029
109Exertional dyspnea (HP:0002875)2.24189850
110Abnormality of macrophages (HP:0004311)2.23252773
111Rib fusion (HP:0000902)2.22467426
112Tinnitus (HP:0000360)2.22217939
113Retrobulbar optic neuritis (HP:0100654)2.22024705
114Optic neuritis (HP:0100653)2.22024705
115Abnormal mitochondria in muscle tissue (HP:0008316)2.21438674
116Hypoglycemic seizures (HP:0002173)2.18898668
117Thrombophlebitis (HP:0004418)2.18544556
118Cholelithiasis (HP:0001081)2.18366995
119Hydroxyprolinuria (HP:0003080)2.17318765
120Abnormality of proline metabolism (HP:0010907)2.17318765
121Increased serum lactate (HP:0002151)2.16964767
122Increased intramyocellular lipid droplets (HP:0012240)2.15480878
123Pancreatitis (HP:0001733)2.12009785
124Homocystinuria (HP:0002156)2.11543620
125Abnormality of homocysteine metabolism (HP:0010919)2.11543620
126Neonatal onset (HP:0003623)2.10635083
127Vomiting (HP:0002013)2.10203589
128Abnormality of iron homeostasis (HP:0011031)2.10089022
129Proximal tubulopathy (HP:0000114)2.08611707
130Gout (HP:0001997)2.07908435
131Opisthotonus (HP:0002179)2.04885316
132Abnormality of transition element cation homeostasis (HP:0011030)2.04286908
133Irritability (HP:0000737)2.03418801
134Hypoplasia of the pons (HP:0012110)2.02184962
135Epistaxis (HP:0000421)2.02004435
136Hemorrhage of the eye (HP:0011885)2.01449123
137Premature graying of hair (HP:0002216)2.01223941
138Malnutrition (HP:0004395)2.00816234
139Abnormal gallbladder physiology (HP:0012438)2.00743555
140Cholecystitis (HP:0001082)2.00743555
141Abnormal cartilage morphology (HP:0002763)2.00723578
142Sensorimotor neuropathy (HP:0007141)1.99205284
143Brushfield spots (HP:0001088)1.97662553
144Progressive macrocephaly (HP:0004481)1.97055253
145Lactic acidosis (HP:0003128)1.96886856
146Amyloidosis (HP:0011034)1.96388780
147Abnormality of the pons (HP:0007361)1.95873162
148Enlarged kidneys (HP:0000105)1.94888719
149Purpura (HP:0000979)1.92707955
150Protruding tongue (HP:0010808)1.91571439
151Abnormal drinking behavior (HP:0030082)1.91294991
152Polydipsia (HP:0001959)1.91294991
153Clumsiness (HP:0002312)1.91084854
154Poikilocytosis (HP:0004447)1.90511620
155Late onset (HP:0003584)1.90005336
156Elevated hepatic transaminases (HP:0002910)1.89639157
157Nephritis (HP:0000123)1.88677315
158Recurrent abscess formation (HP:0002722)1.88512876
159Abolished electroretinogram (ERG) (HP:0000550)1.86981061
160Paralysis (HP:0003470)1.86970420
161Bony spicule pigmentary retinopathy (HP:0007737)1.85084544
162Optic disc pallor (HP:0000543)1.84830628
163Pancreatic cysts (HP:0001737)1.83747654
164Glycosuria (HP:0003076)1.82593018
165Abnormality of urine glucose concentration (HP:0011016)1.82593018
166Abnormality of the gallbladder (HP:0005264)1.82141408
167Rectovaginal fistula (HP:0000143)1.81886148
168Rectal fistula (HP:0100590)1.81886148
169Respiratory difficulties (HP:0002880)1.81454364
170Vaginal fistula (HP:0004320)1.81295651
171Hyperinsulinemic hypoglycemia (HP:0000825)1.81270459
172Recurrent bacterial skin infections (HP:0005406)1.80801681
173Abnormal enzyme/coenzyme activity (HP:0012379)1.80514758
174Reduced antithrombin III activity (HP:0001976)1.78561925
175Methylmalonic aciduria (HP:0012120)1.76728198
176Macular degeneration (HP:0000608)1.74429482
177Abnormality of renal resorption (HP:0011038)1.74130155
178Increased serum ferritin (HP:0003281)1.73767895
179Ileus (HP:0002595)1.73666745
180Bile duct proliferation (HP:0001408)1.73400990
181Abnormal biliary tract physiology (HP:0012439)1.73400990
182Elevated erythrocyte sedimentation rate (HP:0003565)1.73285487
183Poikiloderma (HP:0001029)1.70263483
184Dysostosis multiplex (HP:0000943)1.70025611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.95410971
2ERN13.88237793
3FGFR43.43891595
4SIK13.41659480
5PDK23.29083765
6RIPK43.23854858
7TLK12.82550693
8TAOK32.69900679
9ADRBK22.68985707
10INSRR2.54453801
11NEK92.52124996
12PKN22.51798626
13FLT32.45946789
14TYK22.08637441
15WNK42.07433124
16PIK3CG2.03565108
17MST1R2.00545248
18MAP3K141.99012245
19KDR1.98374075
20IRAK31.95571902
21TESK21.90414625
22FRK1.84276062
23ERBB41.78298884
24EIF2AK11.75306488
25ABL21.74713829
26TBK11.74410874
27BMPR1B1.65945872
28TXK1.64171373
29MAP2K31.58419367
30MAPK111.55695215
31TNK21.54548836
32ADRBK11.45403135
33OXSR11.43056086
34IRAK41.40801414
35JAK21.31531065
36JAK11.30133879
37MAP2K41.29143583
38TRIB31.21784028
39BLK1.21460003
40PTK61.20119115
41KIT1.18354013
42CAMKK21.18123975
43TGFBR21.15945438
44MARK31.13883804
45GRK71.12391325
46LATS11.10305460
47MAPK151.08951689
48CDK61.06558761
49GRK11.03801510
50BUB11.03569578
51CDK191.02659796
52CSF1R1.02599855
53NME21.01258839
54DAPK10.99676792
55PBK0.97931862
56SYK0.97291845
57PRKAA20.96502786
58GRK50.95947792
59MAP3K30.94457049
60WNK30.90941656
61EPHA30.90507357
62EIF2AK30.88621942
63MATK0.88607521
64CSK0.88020411
65MAP3K110.87639854
66NME10.85825763
67NUAK10.84150014
68TIE10.83150544
69MYLK0.81530662
70PINK10.79024008
71IKBKE0.77424035
72MAPKAPK30.77066162
73MAPK40.76575703
74BTK0.76431412
75GRK60.75696027
76BMPR20.74730177
77STK38L0.73467134
78PHKG10.68010458
79PHKG20.68010458
80EIF2AK20.67650019
81EPHB10.67582462
82MST40.67555426
83PDPK10.67484669
84SIK20.67057083
85IKBKB0.66731024
86PTK2B0.64522120
87PAK10.61791309
88HCK0.61672133
89MAP3K70.61656895
90DYRK1B0.61356382
91DAPK20.61122738
92TEC0.60578317
93PIM20.60267263
94JAK30.58818525
95MAP2K60.57624593
96PKN10.56954876
97RIPK10.56643524
98IRAK10.56613034
99RPS6KA50.56300436
100MAP3K50.56288208
101ERBB20.55488186
102PRKACG0.55352568
103CAMK10.54882995
104CDK40.54839895
105STK30.53702072
106PRKG20.51862552
107TRPM70.51704359
108LYN0.50866561
109ZAP700.49923116
110TTN0.49466230
111MAPK130.49334784
112PDK30.48795753
113PDK40.48795753
114MET0.48539674
115MAP4K10.48452342
116IGF1R0.48016591
117OBSCN0.47227084
118FGFR30.46366279
119PRKAA10.46040215
120BMX0.45789045
121IRAK20.45591151
122GSK3A0.45397969
123PDK10.45074123
124TGFBR10.43972553
125PRKCZ0.43861150
126MAP4K20.43682262
127TAOK20.43537072
128TNIK0.42499312
129NEK20.42245444
130NTRK30.41933876
131MAPK120.40742592
132LRRK20.39262148
133NEK10.39031037
134SCYL20.38807263
135MAP3K100.38686162
136PRKCQ0.37799334
137CAMK1D0.37734083
138ACVR1B0.37280538
139STK160.36928227
140STK40.36598980
141PIM10.36158875
142MUSK0.34967566
143ZAK0.34044521
144ABL10.34037131
145PRKCD0.33899359
146DAPK30.33820552
147RPS6KA40.33202885
148RAF10.32544611
149PRKCG0.31773596
150BRSK20.31700791
151LCK0.30625524
152WNK10.29788839

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.34435196
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.49626563
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32857795
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15051002
5Nitrogen metabolism_Homo sapiens_hsa009103.13095916
6Arginine biosynthesis_Homo sapiens_hsa002202.86814667
7Complement and coagulation cascades_Homo sapiens_hsa046102.75638748
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.74949915
9Tryptophan metabolism_Homo sapiens_hsa003802.68958670
10Fatty acid degradation_Homo sapiens_hsa000712.62886468
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55163776
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.49646802
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47060234
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45577174
15Oxidative phosphorylation_Homo sapiens_hsa001902.37182245
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36995588
17Peroxisome_Homo sapiens_hsa041462.16162556
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09570199
19Propanoate metabolism_Homo sapiens_hsa006402.02611048
20Staphylococcus aureus infection_Homo sapiens_hsa051502.01972984
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01259114
22Histidine metabolism_Homo sapiens_hsa003401.97112367
23RNA polymerase_Homo sapiens_hsa030201.97018095
24Chemical carcinogenesis_Homo sapiens_hsa052041.93109822
25Butanoate metabolism_Homo sapiens_hsa006501.91088786
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90875926
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.90433844
28Parkinsons disease_Homo sapiens_hsa050121.88458710
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.84547251
30PPAR signaling pathway_Homo sapiens_hsa033201.83074875
31Fatty acid metabolism_Homo sapiens_hsa012121.81166171
32beta-Alanine metabolism_Homo sapiens_hsa004101.77680578
33Caffeine metabolism_Homo sapiens_hsa002321.77245685
34Proteasome_Homo sapiens_hsa030501.75680238
35Homologous recombination_Homo sapiens_hsa034401.69627212
36Selenocompound metabolism_Homo sapiens_hsa004501.68779372
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68046411
38Retinol metabolism_Homo sapiens_hsa008301.66861577
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66712735
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59431909
41Phenylalanine metabolism_Homo sapiens_hsa003601.52054807
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49435915
43Starch and sucrose metabolism_Homo sapiens_hsa005001.47409424
44Pyruvate metabolism_Homo sapiens_hsa006201.42967379
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41221347
46Tyrosine metabolism_Homo sapiens_hsa003501.39186440
47Folate biosynthesis_Homo sapiens_hsa007901.37098061
48Carbon metabolism_Homo sapiens_hsa012001.29288667
49Bile secretion_Homo sapiens_hsa049761.27392300
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.26666666
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25601194
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22905274
53Biosynthesis of amino acids_Homo sapiens_hsa012301.22867638
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21796269
55Sulfur metabolism_Homo sapiens_hsa009201.20882606
56Alzheimers disease_Homo sapiens_hsa050101.19949456
57ABC transporters_Homo sapiens_hsa020101.19767646
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19228391
59Fatty acid elongation_Homo sapiens_hsa000621.18874500
60Huntingtons disease_Homo sapiens_hsa050161.17738589
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10696120
62NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10479105
63Steroid biosynthesis_Homo sapiens_hsa001001.09372720
64Fat digestion and absorption_Homo sapiens_hsa049751.07307812
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07261362
66One carbon pool by folate_Homo sapiens_hsa006700.98187908
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98087020
68Collecting duct acid secretion_Homo sapiens_hsa049660.98017054
69Arginine and proline metabolism_Homo sapiens_hsa003300.97707106
70Sulfur relay system_Homo sapiens_hsa041220.94019227
71Nicotine addiction_Homo sapiens_hsa050330.89809573
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83737125
73Vitamin digestion and absorption_Homo sapiens_hsa049770.83656939
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82516139
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.81886930
76Glutathione metabolism_Homo sapiens_hsa004800.81218185
77Fanconi anemia pathway_Homo sapiens_hsa034600.80591042
78Lysine degradation_Homo sapiens_hsa003100.78274822
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.76142977
80Vitamin B6 metabolism_Homo sapiens_hsa007500.75774404
81Phototransduction_Homo sapiens_hsa047440.74741135
82Osteoclast differentiation_Homo sapiens_hsa043800.73978903
83Pentose phosphate pathway_Homo sapiens_hsa000300.73634524
84Purine metabolism_Homo sapiens_hsa002300.69640081
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.69381838
86Sphingolipid metabolism_Homo sapiens_hsa006000.69350582
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68075795
88Morphine addiction_Homo sapiens_hsa050320.67790969
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67566104
90Tuberculosis_Homo sapiens_hsa051520.66685716
91Olfactory transduction_Homo sapiens_hsa047400.64124518
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59637743
93Ether lipid metabolism_Homo sapiens_hsa005650.58766649
94Glycerolipid metabolism_Homo sapiens_hsa005610.58118276
95Rheumatoid arthritis_Homo sapiens_hsa053230.57986024
96Hematopoietic cell lineage_Homo sapiens_hsa046400.55576549
97Metabolic pathways_Homo sapiens_hsa011000.50061356
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46388583
99Ovarian steroidogenesis_Homo sapiens_hsa049130.45605303
100Fatty acid biosynthesis_Homo sapiens_hsa000610.45522281
101Taste transduction_Homo sapiens_hsa047420.44139017
102Mismatch repair_Homo sapiens_hsa034300.44133553
103Mineral absorption_Homo sapiens_hsa049780.44107237
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42122458
105Galactose metabolism_Homo sapiens_hsa000520.41265729
106Synaptic vesicle cycle_Homo sapiens_hsa047210.39969547
107Fructose and mannose metabolism_Homo sapiens_hsa000510.35496021
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.27112491
109Insulin resistance_Homo sapiens_hsa049310.26677415
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.22720500
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18972242
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17106030
113Prion diseases_Homo sapiens_hsa050200.17002489
114Linoleic acid metabolism_Homo sapiens_hsa005910.16624996
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11318597
116Legionellosis_Homo sapiens_hsa051340.05621033
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.02952177
118Pertussis_Homo sapiens_hsa051330.02483743
119Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1321295
120Insulin signaling pathway_Homo sapiens_hsa04910-0.1208606
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.1186821
122Hepatitis C_Homo sapiens_hsa05160-0.1163867
123Leishmaniasis_Homo sapiens_hsa05140-0.1160243
124Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.1087015
125African trypanosomiasis_Homo sapiens_hsa05143-0.1057386
126Regulation of autophagy_Homo sapiens_hsa04140-0.1002836
127Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0942248
128Malaria_Homo sapiens_hsa05144-0.0891006
129Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0885151
130Pyrimidine metabolism_Homo sapiens_hsa00240-0.0672324
131Lysosome_Homo sapiens_hsa04142-0.0652278
132Other glycan degradation_Homo sapiens_hsa00511-0.0549688
133AMPK signaling pathway_Homo sapiens_hsa04152-0.0448022
134Glucagon signaling pathway_Homo sapiens_hsa04922-0.0264732
135Renin-angiotensin system_Homo sapiens_hsa04614-0.0226074
136Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0222563
137Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0089189

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