NR1D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.87521160
2synaptic vesicle exocytosis (GO:0016079)4.36357557
3keratinization (GO:0031424)4.02553224
4cerebellar granule cell differentiation (GO:0021707)3.99949131
5positive regulation of synapse maturation (GO:0090129)3.92036804
6regulation of synaptic vesicle exocytosis (GO:2000300)3.91818693
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.82866928
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.67115088
9neuronal ion channel clustering (GO:0045161)3.64734854
10alpha-linolenic acid metabolic process (GO:0036109)3.58082328
11cytoskeletal anchoring at plasma membrane (GO:0007016)3.53602314
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52256957
13L-phenylalanine catabolic process (GO:0006559)3.42818552
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.42818552
15regulation of synaptic vesicle transport (GO:1902803)3.40284046
16neurotransmitter secretion (GO:0007269)3.37327767
17regulation of ARF protein signal transduction (GO:0032012)3.35633510
18sulfur amino acid catabolic process (GO:0000098)3.31705564
19dicarboxylic acid biosynthetic process (GO:0043650)3.25502758
20potassium ion homeostasis (GO:0055075)3.25278024
21L-phenylalanine metabolic process (GO:0006558)3.24710526
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.24710526
23regulation of synapse maturation (GO:0090128)3.18242077
24positive regulation of fatty acid beta-oxidation (GO:0032000)3.16155303
25lysine metabolic process (GO:0006553)3.12772556
26lysine catabolic process (GO:0006554)3.12772556
27peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.10704724
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.09898548
29desmosome organization (GO:0002934)3.09403999
30cellular sodium ion homeostasis (GO:0006883)3.03982607
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03156443
32positive regulation of fatty acid oxidation (GO:0046321)3.02232848
33high-density lipoprotein particle remodeling (GO:0034375)3.02053495
34fatty acid transmembrane transport (GO:1902001)3.01643437
35regulation of neuronal synaptic plasticity (GO:0048168)3.01503285
36glutamate metabolic process (GO:0006536)3.01161991
37positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.00024367
38carnitine shuttle (GO:0006853)2.98670751
392-oxoglutarate metabolic process (GO:0006103)2.98352573
40reverse cholesterol transport (GO:0043691)2.97140382
41cysteine metabolic process (GO:0006534)2.94436726
42regulation of triglyceride catabolic process (GO:0010896)2.89061774
43short-chain fatty acid metabolic process (GO:0046459)2.86630478
44neurotransmitter-gated ion channel clustering (GO:0072578)2.86316719
45aromatic amino acid family catabolic process (GO:0009074)2.86108499
46myelination in peripheral nervous system (GO:0022011)2.84571348
47peripheral nervous system axon ensheathment (GO:0032292)2.84571348
48aspartate family amino acid catabolic process (GO:0009068)2.83282691
49bile acid biosynthetic process (GO:0006699)2.79710934
50cellular ketone body metabolic process (GO:0046950)2.79641950
51fatty acid beta-oxidation (GO:0006635)2.78531573
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78211843
53amino acid import (GO:0043090)2.77456557
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.76669430
55kynurenine metabolic process (GO:0070189)2.74853978
56myelin maintenance (GO:0043217)2.74325851
57cellular modified amino acid catabolic process (GO:0042219)2.73040982
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72539576
59amino-acid betaine metabolic process (GO:0006577)2.71035828
60dicarboxylic acid catabolic process (GO:0043649)2.69828184
61regulation of cholesterol esterification (GO:0010872)2.69170572
62synaptic vesicle docking involved in exocytosis (GO:0016081)2.68564731
63fatty acid homeostasis (GO:0055089)2.68387085
64ethanol oxidation (GO:0006069)2.67829987
65cellular potassium ion homeostasis (GO:0030007)2.67551569
66alanine transport (GO:0032328)2.67439384
67regulation of p38MAPK cascade (GO:1900744)2.67202803
68regulation of long-term neuronal synaptic plasticity (GO:0048169)2.66215144
69glyoxylate metabolic process (GO:0046487)2.66066406
70regulation of fatty acid oxidation (GO:0046320)2.65844168
71phospholipid homeostasis (GO:0055091)2.64965469
72regulation of fatty acid beta-oxidation (GO:0031998)2.64156228
73positive regulation of lipid catabolic process (GO:0050996)2.63642187
74cellular glucuronidation (GO:0052695)2.63469946
75lipid oxidation (GO:0034440)2.62325310
76establishment of skin barrier (GO:0061436)2.62159479
77fatty acid oxidation (GO:0019395)2.62087942
78neuronal action potential propagation (GO:0019227)2.62072481
79regulation of synaptic plasticity (GO:0048167)2.61726894
80acylglycerol homeostasis (GO:0055090)2.60603794
81triglyceride homeostasis (GO:0070328)2.60603794
82* regulation of cholesterol homeostasis (GO:2000188)2.60169144
83hormone catabolic process (GO:0042447)2.59603294
84positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.58985670
85L-amino acid import (GO:0043092)2.58120833
86peptide cross-linking (GO:0018149)2.56649532
87neurotransmitter transport (GO:0006836)2.56425524
88fatty acid catabolic process (GO:0009062)2.56424601
89plasma lipoprotein particle remodeling (GO:0034369)2.55898229
90protein-lipid complex remodeling (GO:0034368)2.55898229
91macromolecular complex remodeling (GO:0034367)2.55898229
92xenobiotic catabolic process (GO:0042178)2.55156691
93monocarboxylic acid catabolic process (GO:0072329)2.54770607
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.54747581
95glutamate secretion (GO:0014047)2.54580961
96cell communication by electrical coupling (GO:0010644)2.53993087
97regulation of triglyceride biosynthetic process (GO:0010866)2.53473076
98homocysteine metabolic process (GO:0050667)2.51657273
99regulation of water loss via skin (GO:0033561)2.51174655
100complement activation, alternative pathway (GO:0006957)2.50887358
101acetyl-CoA metabolic process (GO:0006084)2.50552085
102regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50281480
103alpha-amino acid catabolic process (GO:1901606)2.49712162
104response to gravity (GO:0009629)2.49412592
105tryptophan catabolic process (GO:0006569)2.49298934
106indole-containing compound catabolic process (GO:0042436)2.49298934
107indolalkylamine catabolic process (GO:0046218)2.49298934
108cellular amino acid catabolic process (GO:0009063)2.48416029
109phospholipid efflux (GO:0033700)2.47600075
110sodium ion export (GO:0071436)2.47367743
111regulation of protein activation cascade (GO:2000257)2.47234827
112regulation of cholesterol biosynthetic process (GO:0045540)2.46840543
113neuromuscular process controlling balance (GO:0050885)2.46460219
114skin morphogenesis (GO:0043589)2.45796110
115skeletal muscle adaptation (GO:0043501)2.45794966
116chemosensory behavior (GO:0007635)2.45611840
117urea metabolic process (GO:0019627)2.45350562
118urea cycle (GO:0000050)2.45350562
119lung epithelium development (GO:0060428)2.45177138
120vocalization behavior (GO:0071625)2.44370604
121positive regulation of triglyceride metabolic process (GO:0090208)2.44356864
122flavonoid metabolic process (GO:0009812)2.43958337
123positive regulation of fatty acid metabolic process (GO:0045923)2.43407287
124positive regulation of Rap GTPase activity (GO:0032854)2.43257962
125striated muscle hypertrophy (GO:0014897)2.42796029
126regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.42001788
127coenzyme catabolic process (GO:0009109)2.41520782
128biotin metabolic process (GO:0006768)2.41248467
129carnitine metabolic process (GO:0009437)2.40935831
130regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.40751140
131glucuronate metabolic process (GO:0019585)2.40712581
132uronic acid metabolic process (GO:0006063)2.40712581
133positive regulation of protein dephosphorylation (GO:0035307)2.40497489
134cell communication involved in cardiac conduction (GO:0086065)2.39089936
135creatine metabolic process (GO:0006600)2.39083892
136peptidyl-glutamic acid carboxylation (GO:0017187)2.38419071
137protein carboxylation (GO:0018214)2.38419071
138negative regulation of fibrinolysis (GO:0051918)2.37949774
139bile acid metabolic process (GO:0008206)2.37815110
140nitrogen cycle metabolic process (GO:0071941)2.37232063
141regulation of complement activation (GO:0030449)2.36873603
142negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.36453288
143activation of protein kinase A activity (GO:0034199)2.36309322
144detection of calcium ion (GO:0005513)2.36297002
145ketone body metabolic process (GO:1902224)2.36276416
146carnitine transmembrane transport (GO:1902603)2.36215400
147locomotory exploration behavior (GO:0035641)2.36184580
148cerebellar Purkinje cell layer development (GO:0021680)2.35886948
149regulation of triglyceride metabolic process (GO:0090207)2.35754275
150keratinocyte proliferation (GO:0043616)2.35634890
151regulation of sequestering of triglyceride (GO:0010889)2.35176371
152negative regulation of actin filament bundle assembly (GO:0032232)2.34484308
153regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.34136835
154regulation of early endosome to late endosome transport (GO:2000641)2.33972309
155protein targeting to plasma membrane (GO:0072661)2.33339749
156potassium ion import (GO:0010107)2.33298622
157regulation of female receptivity (GO:0045924)2.32371706
158regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.29213016
159macroautophagy (GO:0016236)2.28599039
160cell volume homeostasis (GO:0006884)2.26268164
161cerebellar Purkinje cell differentiation (GO:0021702)2.25450743
162phosphate ion transmembrane transport (GO:0035435)2.25433854
163negative regulation of dendrite morphogenesis (GO:0050774)2.23881760
164activation of MAPKKK activity (GO:0000185)2.23773718
165synaptic vesicle endocytosis (GO:0048488)2.23382826
166regulation of voltage-gated calcium channel activity (GO:1901385)2.22939920
167regulation of vesicle fusion (GO:0031338)2.22605672
168regulation of cell communication by electrical coupling (GO:0010649)2.21562097
169regulation of neurotransmitter levels (GO:0001505)2.20806077
170multicellular organismal water homeostasis (GO:0050891)2.18970978
171negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.18088025
172regulation of neurotransmitter secretion (GO:0046928)2.17444625
173regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.14953000
174negative regulation of stress fiber assembly (GO:0051497)2.14837044
175glomerular basement membrane development (GO:0032836)2.14593610
176positive regulation of neurotransmitter secretion (GO:0001956)2.14527908
177positive regulation of dendritic spine development (GO:0060999)2.14199687
178positive regulation of neurotransmitter transport (GO:0051590)2.13919690
179regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.11963843
180regulation of glutamate receptor signaling pathway (GO:1900449)2.11192348
181peptidyl-proline hydroxylation (GO:0019511)2.10581125
182focal adhesion assembly (GO:0048041)2.10527591
183cell-substrate adherens junction assembly (GO:0007045)2.10527591
184positive regulation of membrane potential (GO:0045838)2.10035360
185protein localization to endosome (GO:0036010)2.10021985
186cardiac muscle contraction (GO:0060048)2.09951763
187muscle hypertrophy (GO:0014896)2.09597207
188axon ensheathment in central nervous system (GO:0032291)2.09396084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.58851519
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.39323585
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.38369464
4* LXR_22158963_ChIP-Seq_LIVER_Mouse2.89016278
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.86571448
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.83527404
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.66237521
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.44250493
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14479170
10* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10080874
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06056523
12EZH2_22144423_ChIP-Seq_EOC_Human1.94142040
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87028782
14DROSHA_22980978_ChIP-Seq_HELA_Human1.84132303
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81970723
16ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78525202
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74968143
18GBX2_23144817_ChIP-Seq_PC3_Human1.72233639
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70239255
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70239255
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69334401
22RACK7_27058665_Chip-Seq_MCF-7_Human1.66901962
23KDM2B_26808549_Chip-Seq_DND41_Human1.66108084
24CLOCK_20551151_ChIP-Seq_293T_Human1.65878444
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62789698
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62575449
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62119722
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.61859235
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.58030603
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57382111
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55803048
32* ELK3_25401928_ChIP-Seq_HUVEC_Human1.55181572
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54678974
34* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51126253
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.48422671
36TCF7_22412390_ChIP-Seq_EML_Mouse1.46934763
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45922557
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45810262
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41199976
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.41071157
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40354195
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39383592
43* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39042747
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.38813786
45AR_21572438_ChIP-Seq_LNCaP_Human1.38217906
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37682033
47TET1_21490601_ChIP-Seq_MESCs_Mouse1.36397429
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36055546
49* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33100622
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32948422
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32010548
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31359445
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.31227395
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28510030
55SMC4_20622854_ChIP-Seq_HELA_Human1.28138396
56* RARB_27405468_Chip-Seq_BRAIN_Mouse1.28029656
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27746222
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26675490
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26580657
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.26248218
61* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26107738
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.25589139
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.23953907
64* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23728220
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23008213
66* FOXA2_19822575_ChIP-Seq_HepG2_Human1.22780508
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21504925
68* CREB1_26743006_Chip-Seq_LNCaP_Human1.21294036
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18025191
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17672166
71* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16966991
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16779431
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.15274077
74* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13745567
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.13664309
76P68_20966046_ChIP-Seq_HELA_Human1.12944013
77REST_21632747_ChIP-Seq_MESCs_Mouse1.12692342
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12614903
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11375269
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10289857
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09667933
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08520010
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06300695
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.05249537
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.05249537
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.04422783
87* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02417678
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02339912
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01983855
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01493120
91* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01316385
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01188678
93TP53_23651856_ChIP-Seq_MEFs_Mouse1.00467174
94BCAT_22108803_ChIP-Seq_LS180_Human0.98413540
95* REST_18959480_ChIP-ChIP_MESCs_Mouse0.98255872
96RXR_22108803_ChIP-Seq_LS180_Human0.97905657
97* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97905351
98ESR1_21235772_ChIP-Seq_MCF-7_Human0.97527142
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97516655
100* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97396352
101TP63_22573176_ChIP-Seq_HFKS_Human0.95749661
102* ATF3_27146783_Chip-Seq_COLON_Human0.95693205
103AHR_22903824_ChIP-Seq_MCF-7_Human0.95653671
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95558900
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95558900
106KDM2B_26808549_Chip-Seq_K562_Human0.95291880
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94861059
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93669523
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93640402
110STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93187506
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91746803
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91080308
113SMAD4_21799915_ChIP-Seq_A2780_Human0.90242853
114ZNF263_19887448_ChIP-Seq_K562_Human0.90175822
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.87128335
116* RING1B_27294783_Chip-Seq_ESCs_Mouse0.86625413
117SOX2_21211035_ChIP-Seq_LN229_Gbm0.86371108
118TP53_16413492_ChIP-PET_HCT116_Human0.85841205
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.85743915
120SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85346304
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.85143000
122CTCF_27219007_Chip-Seq_Bcells_Human0.85126989
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85034219
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83667327
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83374931
126* LXR_22292898_ChIP-Seq_THP-1_Human0.83132992
127* AR_19668381_ChIP-Seq_PC3_Human0.82942758
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81980078
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.81574670
130CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80365439
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80071313
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.79235228
133IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79124367
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78011912
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77387652
136AR_25329375_ChIP-Seq_VCAP_Human0.76226601
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.76066646
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.75735751
139PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75137540
140* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75065188
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.74825985
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.73583402
143CDX2_20551321_ChIP-Seq_CACO-2_Human0.72343859
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.71978819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.22543519
2MP0005360_urolithiasis3.95442377
3MP0008875_abnormal_xenobiotic_pharmacok3.38136323
4MP0005085_abnormal_gallbladder_physiolo3.27929126
5* MP0005365_abnormal_bile_salt3.11717017
6MP0002837_dystrophic_cardiac_calcinosis3.07156245
7* MP0010329_abnormal_lipoprotein_level2.53537831
8MP0010234_abnormal_vibrissa_follicle2.46369530
9MP0004130_abnormal_muscle_cell2.44405443
10MP0005257_abnormal_intraocular_pressure2.31913950
11MP0002796_impaired_skin_barrier2.30017582
12MP0009840_abnormal_foam_cell2.28406815
13MP0003646_muscle_fatigue2.23155537
14MP0005423_abnormal_somatic_nervous2.22382509
15MP0004885_abnormal_endolymph2.21309744
16MP0000751_myopathy2.19959897
17MP0009780_abnormal_chondrocyte_physiolo2.17879327
18MP0005275_abnormal_skin_tensile2.15434056
19MP0004859_abnormal_synaptic_plasticity2.07766188
20MP0005377_hearing/vestibular/ear_phenot2.07102251
21MP0003878_abnormal_ear_physiology2.07102251
22MP0005670_abnormal_white_adipose2.04018999
23MP0003252_abnormal_bile_duct2.01310391
24MP0003880_abnormal_central_pattern1.92714190
25MP0005409_darkened_coat_color1.92441305
26MP0002909_abnormal_adrenal_gland1.85810079
27MP0005332_abnormal_amino_acid1.85501035
28MP0004215_abnormal_myocardial_fiber1.79127250
29MP0002254_reproductive_system_inflammat1.76460315
30MP0004510_myositis1.72181523
31MP0003329_amyloid_beta_deposits1.71743710
32MP0003806_abnormal_nucleotide_metabolis1.69647469
33MP0002822_catalepsy1.69005630
34* MP0002118_abnormal_lipid_homeostasis1.67572334
35MP0000579_abnormal_nail_morphology1.64879647
36MP0010368_abnormal_lymphatic_system1.63601630
37MP0005083_abnormal_biliary_tract1.62332207
38MP0004036_abnormal_muscle_relaxation1.58482865
39MP0005666_abnormal_adipose_tissue1.52711746
40MP0000920_abnormal_myelination1.47149789
41MP0005503_abnormal_tendon_morphology1.43848241
42MP0003635_abnormal_synaptic_transmissio1.41725726
43MP0005551_abnormal_eye_electrophysiolog1.41700105
44MP0003453_abnormal_keratinocyte_physiol1.41563007
45MP0001666_abnormal_nutrient_absorption1.41212854
46MP0003705_abnormal_hypodermis_morpholog1.40623507
47MP0004084_abnormal_cardiac_muscle1.39624784
48MP0008438_abnormal_cutaneous_collagen1.39558496
49MP0003690_abnormal_glial_cell1.35403731
50MP0000749_muscle_degeneration1.35167133
51MP0003045_fibrosis1.33606976
52MP0003191_abnormal_cellular_cholesterol1.32321367
53MP0002090_abnormal_vision1.32221547
54MP0003195_calcinosis1.29667385
55MP0000013_abnormal_adipose_tissue1.27684420
56* MP0000759_abnormal_skeletal_muscle1.27477159
57MP0005646_abnormal_pituitary_gland1.27284842
58MP0004270_analgesia1.25906331
59MP0004043_abnormal_pH_regulation1.25457868
60MP0005330_cardiomyopathy1.25235837
61MP0005620_abnormal_muscle_contractility1.23360563
62MP0004019_abnormal_vitamin_homeostasis1.23217899
63MP0002971_abnormal_brown_adipose1.21508170
64MP0001501_abnormal_sleep_pattern1.21446772
65MP0004185_abnormal_adipocyte_glucose1.19161879
66MP0003011_delayed_dark_adaptation1.18160463
67MP0002972_abnormal_cardiac_muscle1.15765110
68MP0001348_abnormal_lacrimal_gland1.14965854
69MP0002734_abnormal_mechanical_nocicepti1.14728687
70MP0005451_abnormal_body_composition1.14236385
71MP0008961_abnormal_basal_metabolism1.14094848
72MP0004085_abnormal_heartbeat1.13988356
73MP0005535_abnormal_body_temperature1.12408697
74MP0002295_abnormal_pulmonary_circulatio1.12171976
75MP0009745_abnormal_behavioral_response1.11022387
76MP0002063_abnormal_learning/memory/cond1.10243711
77MP0002064_seizures1.09477819
78MP0003137_abnormal_impulse_conducting1.09213575
79MP0003075_altered_response_to1.08768537
80MP0005319_abnormal_enzyme/_coenzyme1.08762593
81* MP0004087_abnormal_muscle_fiber1.08749180
82MP0005375_adipose_tissue_phenotype1.08531372
83* MP0000609_abnormal_liver_physiology1.06933582
84MP0006138_congestive_heart_failure1.06919470
85MP0005501_abnormal_skin_physiology1.06522642
86MP0005584_abnormal_enzyme/coenzyme_acti1.05819476
87MP0003566_abnormal_cell_adhesion1.04472300
88MP0002060_abnormal_skin_morphology1.03227702
89MP0002269_muscular_atrophy1.02934547
90* MP0001502_abnormal_circadian_rhythm1.02643816
91MP0002108_abnormal_muscle_morphology1.01847120
92MP0009046_muscle_twitch1.01482618
93MP0003123_paternal_imprinting1.00962948
94MP0000604_amyloidosis1.00852211
95MP0005058_abnormal_lysosome_morphology1.00481869
96MP0002078_abnormal_glucose_homeostasis0.99472350
97MP0001984_abnormal_olfaction0.97643250
98MP0001486_abnormal_startle_reflex0.95560371
99MP0008569_lethality_at_weaning0.95533756
100MP0002106_abnormal_muscle_physiology0.94690264
101MP0005023_abnormal_wound_healing0.94194820
102MP0005369_muscle_phenotype0.93725486
103MP0002572_abnormal_emotion/affect_behav0.92886817
104MP0003633_abnormal_nervous_system0.91347041
105MP0003634_abnormal_glial_cell0.90577032
106MP0003868_abnormal_feces_composition0.90462170
107MP0003172_abnormal_lysosome_physiology0.90357800
108MP0001958_emphysema0.89986708
109MP0000230_abnormal_systemic_arterial0.89219568
110MP0002933_joint_inflammation0.89095176
111MP0001544_abnormal_cardiovascular_syste0.89023892
112MP0005385_cardiovascular_system_phenoty0.89023892
113MP0004858_abnormal_nervous_system0.88363174
114MP0004484_altered_response_of0.88071819
115MP0003091_abnormal_cell_migration0.86667493
116MP0005334_abnormal_fat_pad0.85752638
117MP0002066_abnormal_motor_capabilities/c0.85646417
118MP0000747_muscle_weakness0.85401724
119MP0004272_abnormal_basement_membrane0.84931813
120MP0002272_abnormal_nervous_system0.84896307
121MP0005595_abnormal_vascular_smooth0.84797317
122MP0005167_abnormal_blood-brain_barrier0.84484945
123MP0004145_abnormal_muscle_electrophysio0.83982912
124MP0005166_decreased_susceptibility_to0.83855812
125MP0001970_abnormal_pain_threshold0.83572644
126MP0003879_abnormal_hair_cell0.82891197
127MP0004233_abnormal_muscle_weight0.82707276
128MP0008874_decreased_physiological_sensi0.82425486
129MP0003631_nervous_system_phenotype0.80175939
130MP0008872_abnormal_physiological_respon0.79804188
131MP0003279_aneurysm0.79188558
132MP0005448_abnormal_energy_balance0.78769588
133MP0001440_abnormal_grooming_behavior0.77541953
134MP0000750_abnormal_muscle_regeneration0.76034431
135MP0002733_abnormal_thermal_nociception0.74730434
136MP0004947_skin_inflammation0.74727922
137MP0000733_abnormal_muscle_development0.74204329
138MP0009643_abnormal_urine_homeostasis0.73637522
139MP0000003_abnormal_adipose_tissue0.73618055
140MP0001851_eye_inflammation0.73606148
141MP0002332_abnormal_exercise_endurance0.73571223
142MP0002876_abnormal_thyroid_physiology0.72914222
143MP0008775_abnormal_heart_ventricle0.72697960
144MP0002127_abnormal_cardiovascular_syste0.72286314
145MP0005165_increased_susceptibility_to0.72279784
146MP0000762_abnormal_tongue_morphology0.71843986
147MP0000566_synostosis0.71658023

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.55289579
2Xanthomatosis (HP:0000991)3.90782056
3Deep venous thrombosis (HP:0002625)3.84048456
4Intrahepatic cholestasis (HP:0001406)3.61736049
5Supranuclear gaze palsy (HP:0000605)3.61668614
6Diplopia (HP:0000651)3.59335386
7Abnormality of binocular vision (HP:0011514)3.59335386
8Hyperglycinuria (HP:0003108)3.56822769
9Ketoacidosis (HP:0001993)3.49115977
10Ketosis (HP:0001946)3.46534612
11Exercise-induced myalgia (HP:0003738)3.46485591
12Hypoglycemic coma (HP:0001325)3.42068564
13Hyperlipoproteinemia (HP:0010980)3.39514424
14Myoglobinuria (HP:0002913)3.33846159
15Hypoalphalipoproteinemia (HP:0003233)3.32042851
16Type 1 muscle fiber predominance (HP:0003803)3.29691279
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.23755436
18Hyperammonemia (HP:0001987)3.18866918
19Abnormality of glycine metabolism (HP:0010895)3.15997221
20Abnormality of serine family amino acid metabolism (HP:0010894)3.15997221
21Complement deficiency (HP:0004431)2.99895685
22Sudden death (HP:0001699)2.99652665
23Right ventricular cardiomyopathy (HP:0011663)2.94422896
24Hyperglycinemia (HP:0002154)2.89797163
25Muscle fiber inclusion bodies (HP:0100299)2.86267217
26Distal lower limb muscle weakness (HP:0009053)2.86203245
27Action tremor (HP:0002345)2.86035801
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.83189355
29Protrusio acetabuli (HP:0003179)2.82943150
30Nemaline bodies (HP:0003798)2.81702112
31Hypolipoproteinemia (HP:0010981)2.76140555
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.75238296
33Axonal loss (HP:0003447)2.69786629
34Increased variability in muscle fiber diameter (HP:0003557)2.69619549
35Abnormality of skeletal muscle fiber size (HP:0012084)2.66249086
36Distal lower limb amyotrophy (HP:0008944)2.63930159
37Cerebral inclusion bodies (HP:0100314)2.61472868
38Ankle clonus (HP:0011448)2.61107760
39Abnormality of fatty-acid metabolism (HP:0004359)2.60887695
40Gout (HP:0001997)2.60550141
41Hyporeflexia of lower limbs (HP:0002600)2.57744720
42Hyperventilation (HP:0002883)2.56452831
43Epidermoid cyst (HP:0200040)2.55792618
44Abnormality of nail color (HP:0100643)2.55340207
45Syncope (HP:0001279)2.53215269
46Lower limb amyotrophy (HP:0007210)2.48347061
47Hyperinsulinemic hypoglycemia (HP:0000825)2.47691562
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.45524761
49Prolonged QT interval (HP:0001657)2.45061331
50Dysmetric saccades (HP:0000641)2.44067070
51Prolonged partial thromboplastin time (HP:0003645)2.43085694
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42632833
53Focal motor seizures (HP:0011153)2.42444273
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42269069
55Atrioventricular block (HP:0001678)2.41614676
56Exercise-induced muscle cramps (HP:0003710)2.39253253
57Hypobetalipoproteinemia (HP:0003563)2.38864009
58Central scotoma (HP:0000603)2.38238248
59Skin nodule (HP:0200036)2.38225150
60Atrial fibrillation (HP:0005110)2.37516496
61Bundle branch block (HP:0011710)2.37034698
62Febrile seizures (HP:0002373)2.35957249
63Annular pancreas (HP:0001734)2.33159685
64Heart block (HP:0012722)2.32290147
65Mildly elevated creatine phosphokinase (HP:0008180)2.30941704
66Abnormality of the salivary glands (HP:0010286)2.29790805
67EMG: myopathic abnormalities (HP:0003458)2.29769365
68Abnormal atrioventricular conduction (HP:0005150)2.29002165
69Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.28548299
70Ventricular tachycardia (HP:0004756)2.27197577
71Pigmentary retinal degeneration (HP:0001146)2.26829998
72Atonic seizures (HP:0010819)2.26448426
73Muscle fiber splitting (HP:0003555)2.25566832
74Shallow orbits (HP:0000586)2.24630503
75Round ear (HP:0100830)2.21293140
76Hypoglycemic seizures (HP:0002173)2.21130392
77Hyperkalemia (HP:0002153)2.18497600
78Primary atrial arrhythmia (HP:0001692)2.17422782
79Status epilepticus (HP:0002133)2.16998669
80Cholelithiasis (HP:0001081)2.15934808
81Myopathic facies (HP:0002058)2.15296295
82Ventricular fibrillation (HP:0001663)2.14810764
83Ventricular arrhythmia (HP:0004308)2.14045370
84Polycythemia (HP:0001901)2.12770595
85Abnormal gallbladder morphology (HP:0012437)2.11983796
86Vertebral compression fractures (HP:0002953)2.11670358
87Foot dorsiflexor weakness (HP:0009027)2.11208375
88Increased IgE level (HP:0003212)2.11149096
89Rigidity (HP:0002063)2.11126112
90Spinal rigidity (HP:0003306)2.10442863
91Abnormality of the lower motor neuron (HP:0002366)2.10369536
92Epileptic encephalopathy (HP:0200134)2.09964069
93Abnormality of the calf musculature (HP:0001430)2.09781586
94Palpitations (HP:0001962)2.09765133
95Late onset (HP:0003584)2.08658619
96Calf muscle hypertrophy (HP:0008981)2.07691618
97Torticollis (HP:0000473)2.07643629
98Metabolic acidosis (HP:0001942)2.07275874
99Aplasia involving bones of the upper limbs (HP:0009823)2.06585540
100Aplasia of the phalanges of the hand (HP:0009802)2.06585540
101Aplasia involving bones of the extremities (HP:0009825)2.06585540
102Papilledema (HP:0001085)2.06389976
103Truncal ataxia (HP:0002078)2.06248289
104Tetraplegia (HP:0002445)2.06094490
105Cerebral aneurysm (HP:0004944)2.05780907
106Postural instability (HP:0002172)2.05164269
107Abnormality of sulfur amino acid metabolism (HP:0004339)2.04678155
108Asymmetric septal hypertrophy (HP:0001670)2.03854440
109Dicarboxylic aciduria (HP:0003215)2.03569649
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03569649
111Sensorimotor neuropathy (HP:0007141)2.03509902
112Myokymia (HP:0002411)2.03386985
113Hypercortisolism (HP:0001578)2.03270701
114Increased connective tissue (HP:0009025)2.02916545
115Dysmetria (HP:0001310)2.02753122
116Polar cataract (HP:0010696)2.02538220
117Alacrima (HP:0000522)2.02515958
118Acanthosis nigricans (HP:0000956)2.02164380
119Supraventricular tachycardia (HP:0004755)2.00498331
120Depression (HP:0000716)1.98220200
121Hyperglycemia (HP:0003074)1.98203737
122Delayed CNS myelination (HP:0002188)1.97978242
123Neuronal loss in central nervous system (HP:0002529)1.97707353
124Abnormality of purine metabolism (HP:0004352)1.97190671
125Myotonia (HP:0002486)1.97165301
126Broad metatarsal (HP:0001783)1.97039442
127Supraventricular arrhythmia (HP:0005115)1.96917246
128Distal upper limb amyotrophy (HP:0007149)1.96896596
129Upper limb amyotrophy (HP:0009129)1.96896596
130Abnormality of complement system (HP:0005339)1.96457035
131Hypercholesterolemia (HP:0003124)1.96249163
132Rapidly progressive (HP:0003678)1.95965967
133Difficulty running (HP:0009046)1.95270747
134Dysdiadochokinesis (HP:0002075)1.94459063
135Visual hallucinations (HP:0002367)1.93086645
136Abnormality of the foot musculature (HP:0001436)1.91624301
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91487940
138Nuclear cataract (HP:0100018)1.90471570
139Sleep apnea (HP:0010535)1.90114565
140Glomerulonephritis (HP:0000099)1.89837656
141Fat malabsorption (HP:0002630)1.89049022
142Muscle hypertrophy of the lower extremities (HP:0008968)1.88644703
143Hydroxyprolinuria (HP:0003080)1.86218635
144Abnormality of proline metabolism (HP:0010907)1.86218635
145Achilles tendon contracture (HP:0001771)1.84199856
146Scotoma (HP:0000575)1.84094819
147Focal seizures (HP:0007359)1.83794755
148Insomnia (HP:0100785)1.82595500
149Bronchomalacia (HP:0002780)1.82454668
150Conjugated hyperbilirubinemia (HP:0002908)1.82411866
151Congenital stationary night blindness (HP:0007642)1.82192867
152Hyperparathyroidism (HP:0000843)1.82173283
153EMG: neuropathic changes (HP:0003445)1.81430975
154Neck muscle weakness (HP:0000467)1.81027690
155Neurofibrillary tangles (HP:0002185)1.80264484
156Muscle stiffness (HP:0003552)1.79729305
157Corneal erosion (HP:0200020)1.79716071
158Abnormal gallbladder physiology (HP:0012438)1.79471917
159Cholecystitis (HP:0001082)1.79471917
160Generalized tonic-clonic seizures (HP:0002069)1.78339283
161Vascular tortuosity (HP:0004948)1.78338322
162Abnormality of the common coagulation pathway (HP:0010990)1.78108811
163Oligomenorrhea (HP:0000876)1.78092403
164Impaired social interactions (HP:0000735)1.77977718
165Difficulty climbing stairs (HP:0003551)1.75568210
166Absence seizures (HP:0002121)1.75100528
167Intention tremor (HP:0002080)1.71798871
168Hypoplasia of the iris (HP:0007676)1.71142750
169Peripheral hypomyelination (HP:0007182)1.70632002
170Abnormality of the Achilles tendon (HP:0005109)1.69406741
171Focal dystonia (HP:0004373)1.69282321
172Segmental peripheral demyelination/remyelination (HP:0003481)1.67151042
173Spinal canal stenosis (HP:0003416)1.67139135
174Slow saccadic eye movements (HP:0000514)1.66714698
175Growth hormone excess (HP:0000845)1.65704314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.13207834
2EPHA43.04098097
3LMTK22.69557936
4BCKDK2.54468161
5PHKG12.36963116
6PHKG22.36963116
7SIK12.23475655
8DAPK22.06223269
9INSRR1.99898089
10ERN11.92907913
11CDK121.92896056
12RIPK11.88241225
13PRKD31.87299521
14PINK11.87195390
15ARAF1.86150694
16DMPK1.73213131
17UHMK11.69781804
18TTN1.68307362
19EPHA21.56406473
20MAP3K131.56176961
21MAP2K41.55894480
22MARK21.55209571
23MYLK1.54995396
24PDK31.41748077
25PDK41.41748077
26CASK1.41112472
27TESK11.40305491
28SGK31.40007270
29SGK21.37872731
30NTRK31.32349817
31CAMK1D1.31089128
32STK381.30281798
33ICK1.29123120
34MAP3K41.27857288
35SGK2231.22963892
36SGK4941.22963892
37MAP3K71.22388900
38CAMK1G1.20630688
39MAP3K21.19756571
40MARK11.17481574
41PAK61.17385061
42MOS1.17327494
43MAPK121.17322233
44CAMKK11.17111134
45CDC42BPA1.16300616
46TIE11.15272348
47NTRK21.11079177
48MUSK1.09269279
49PDK21.04747472
50OBSCN1.03787501
51FGFR41.01329580
52PTK2B1.00175238
53TRPM70.97475605
54PKN20.96597562
55TAOK10.96164860
56CAMK2B0.94954607
57PAK30.94586459
58PRKD20.93978525
59WNK10.93897082
60MAP3K90.92495104
61PIK3CA0.91282856
62LATS10.91190048
63PRKCH0.87097001
64PDPK10.86426269
65FER0.86054373
66CAMK10.85435727
67SIK20.84965807
68RIPK40.83895772
69MAPK150.83585373
70EPHB10.82652811
71PRPF4B0.82272223
72HIPK20.82110633
73MAPK70.80436898
74KSR20.79642049
75MAP2K70.79635222
76AKT30.78926497
77CAMKK20.78517725
78PRKAA20.78249856
79WNK40.77781482
80EEF2K0.77715240
81FGFR20.77381701
82CAMK40.77222722
83RET0.73304977
84PRKD10.72712213
85ROCK10.71074293
86CDK50.70040371
87MAP2K10.68430728
88PDGFRA0.67906610
89MINK10.67869408
90PRKAA10.67542529
91CAMK2A0.66577704
92MAP3K10.65633853
93NTRK10.65431336
94IRAK30.65146540
95SIK30.64932237
96TAOK20.64731799
97LIMK10.64419976
98PDK10.64162628
99IRAK20.64129080
100MAP3K60.62996741
101MAP3K110.62347174
102STK38L0.62295135
103MAPKAPK30.61990848
104BRAF0.61779235
105PTK60.61643769
106PTK20.61352416
107CAMK2D0.61075588
108MAPK100.59471950
109NEK10.59290293
110NEK60.59259500
111CAMK2G0.57961199
112MTOR0.57146842
113SGK10.57086442
114GRK50.57046560
115MAP2K30.54466060
116MAP2K60.54410800
117PRKACG0.53157176
118MST1R0.52558898
119FGFR30.52286896
120PRKCG0.51922559
121LATS20.51004566
122DDR20.50384837
123MET0.49562772
124BMX0.49440886
125MAPK40.48268349
126PRKCE0.46684720
127MAP3K30.45759683
128PDGFRB0.45663485
129PRKCZ0.44730068
130OXSR10.44381523
131DAPK10.44125613
132EPHA30.43927333
133SMG10.43469030
134ERBB40.43446482
135TYRO30.43423778
136STK110.43030866
137JAK10.42395927
138ROCK20.41469248
139RPS6KA20.41256553

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.16118954
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.60642505
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.47268629
4Fatty acid degradation_Homo sapiens_hsa000712.45611411
5Arginine biosynthesis_Homo sapiens_hsa002202.33422070
6Propanoate metabolism_Homo sapiens_hsa006402.08201965
7Fatty acid metabolism_Homo sapiens_hsa012122.07299526
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04418465
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96089460
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93850363
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87765237
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87605541
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87502009
14Butanoate metabolism_Homo sapiens_hsa006501.86179777
15PPAR signaling pathway_Homo sapiens_hsa033201.83141405
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81487892
17Pancreatic secretion_Homo sapiens_hsa049721.71213541
18Tryptophan metabolism_Homo sapiens_hsa003801.67255351
19Fatty acid biosynthesis_Homo sapiens_hsa000611.65908653
20GnRH signaling pathway_Homo sapiens_hsa049121.51997826
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49977918
22Bile secretion_Homo sapiens_hsa049761.47883703
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44878160
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37085725
25Caffeine metabolism_Homo sapiens_hsa002321.33664255
26Pyruvate metabolism_Homo sapiens_hsa006201.30313526
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29118376
28Peroxisome_Homo sapiens_hsa041461.28953298
29Sulfur metabolism_Homo sapiens_hsa009201.28079120
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27122524
31Complement and coagulation cascades_Homo sapiens_hsa046101.26623291
32Chemical carcinogenesis_Homo sapiens_hsa052041.25603785
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24281007
34Estrogen signaling pathway_Homo sapiens_hsa049151.22413259
35Dopaminergic synapse_Homo sapiens_hsa047281.20314383
36beta-Alanine metabolism_Homo sapiens_hsa004101.19295811
37Starch and sucrose metabolism_Homo sapiens_hsa005001.18218674
38Carbon metabolism_Homo sapiens_hsa012001.17046078
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16949700
40VEGF signaling pathway_Homo sapiens_hsa043701.14062707
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12934340
42Prion diseases_Homo sapiens_hsa050201.12753919
43Glioma_Homo sapiens_hsa052141.11258496
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.07781902
45Phenylalanine metabolism_Homo sapiens_hsa003601.06781433
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04330050
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99648277
48Insulin secretion_Homo sapiens_hsa049110.97837396
49Glycerolipid metabolism_Homo sapiens_hsa005610.97132510
50GABAergic synapse_Homo sapiens_hsa047270.96951704
51Fatty acid elongation_Homo sapiens_hsa000620.96371282
52Melanogenesis_Homo sapiens_hsa049160.96219759
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.95830903
54Inositol phosphate metabolism_Homo sapiens_hsa005620.94275640
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92750330
56Synaptic vesicle cycle_Homo sapiens_hsa047210.92409067
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92374247
58ErbB signaling pathway_Homo sapiens_hsa040120.92321459
59Protein digestion and absorption_Homo sapiens_hsa049740.91245146
60Biosynthesis of amino acids_Homo sapiens_hsa012300.91042130
61Long-term depression_Homo sapiens_hsa047300.88992477
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.87222055
63Thyroid hormone synthesis_Homo sapiens_hsa049180.85754640
64Fat digestion and absorption_Homo sapiens_hsa049750.85637949
65Nicotine addiction_Homo sapiens_hsa050330.84846257
66Vibrio cholerae infection_Homo sapiens_hsa051100.84671627
67ABC transporters_Homo sapiens_hsa020100.84352617
68Circadian entrainment_Homo sapiens_hsa047130.84314300
69AMPK signaling pathway_Homo sapiens_hsa041520.82774585
70Amoebiasis_Homo sapiens_hsa051460.82117215
71Tyrosine metabolism_Homo sapiens_hsa003500.81605649
72MAPK signaling pathway_Homo sapiens_hsa040100.81553535
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81319067
74Salivary secretion_Homo sapiens_hsa049700.81083688
75Retinol metabolism_Homo sapiens_hsa008300.81027672
76Vitamin B6 metabolism_Homo sapiens_hsa007500.80918396
77Histidine metabolism_Homo sapiens_hsa003400.80421092
78Endocytosis_Homo sapiens_hsa041440.80088972
79Focal adhesion_Homo sapiens_hsa045100.79028041
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78895260
81Dilated cardiomyopathy_Homo sapiens_hsa054140.77804269
82Gastric acid secretion_Homo sapiens_hsa049710.77414823
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76681133
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75957734
85Glutamatergic synapse_Homo sapiens_hsa047240.75904362
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.75664668
87ECM-receptor interaction_Homo sapiens_hsa045120.75410992
88mTOR signaling pathway_Homo sapiens_hsa041500.75251728
89Renal cell carcinoma_Homo sapiens_hsa052110.74835642
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74374581
91Gap junction_Homo sapiens_hsa045400.73081210
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72825041
93Ras signaling pathway_Homo sapiens_hsa040140.72778903
94* Circadian rhythm_Homo sapiens_hsa047100.72526684
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72394316
96Glucagon signaling pathway_Homo sapiens_hsa049220.71042265
97Rap1 signaling pathway_Homo sapiens_hsa040150.68949996
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68341791
99Choline metabolism in cancer_Homo sapiens_hsa052310.67553893
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.67247912
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66983887
102Cardiac muscle contraction_Homo sapiens_hsa042600.65800865
103Renin secretion_Homo sapiens_hsa049240.65036763
104Insulin resistance_Homo sapiens_hsa049310.64281290
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.62791485
106Dorso-ventral axis formation_Homo sapiens_hsa043200.62629813
107Type II diabetes mellitus_Homo sapiens_hsa049300.62186490
108Morphine addiction_Homo sapiens_hsa050320.62103926
109Amphetamine addiction_Homo sapiens_hsa050310.61641276
110Phototransduction_Homo sapiens_hsa047440.60444326
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60301555
112Serotonergic synapse_Homo sapiens_hsa047260.60231147
113Fructose and mannose metabolism_Homo sapiens_hsa000510.59752790
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59535327
115Olfactory transduction_Homo sapiens_hsa047400.59299820
116Notch signaling pathway_Homo sapiens_hsa043300.58396315
117Arginine and proline metabolism_Homo sapiens_hsa003300.58284256
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.58097135
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57566950
120HIF-1 signaling pathway_Homo sapiens_hsa040660.56466195
121Collecting duct acid secretion_Homo sapiens_hsa049660.55472712
122Acute myeloid leukemia_Homo sapiens_hsa052210.55241874
123Non-small cell lung cancer_Homo sapiens_hsa052230.54467673
124Lysine degradation_Homo sapiens_hsa003100.54274913
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53620513
126Long-term potentiation_Homo sapiens_hsa047200.53241010
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.53196611
128Galactose metabolism_Homo sapiens_hsa000520.50806731
129Proteoglycans in cancer_Homo sapiens_hsa052050.50576736
130Cocaine addiction_Homo sapiens_hsa050300.49694837
131Calcium signaling pathway_Homo sapiens_hsa040200.49622034
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48207745
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47671293
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47007087
135cAMP signaling pathway_Homo sapiens_hsa040240.46997380
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46525968
137Oxytocin signaling pathway_Homo sapiens_hsa049210.45901868
138Other glycan degradation_Homo sapiens_hsa005110.45815490
139Chronic myeloid leukemia_Homo sapiens_hsa052200.45566351
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45082027
141Selenocompound metabolism_Homo sapiens_hsa004500.44460285
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.44100043
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.43754749
144Cholinergic synapse_Homo sapiens_hsa047250.42380421
145Insulin signaling pathway_Homo sapiens_hsa049100.40660204
146Sulfur relay system_Homo sapiens_hsa041220.39694269
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38983596
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.38764996
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37881787
150Taste transduction_Homo sapiens_hsa047420.37874859
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.37734024
152Staphylococcus aureus infection_Homo sapiens_hsa051500.37143824
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.37099037

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »