NR1H2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.53796462
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.53796462
3antigen processing and presentation of endogenous antigen (GO:0019883)4.97860021
4negative regulation of cell killing (GO:0031342)4.24311413
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.24311413
6response to peptidoglycan (GO:0032494)4.03985048
7regulation of gamma-delta T cell differentiation (GO:0045586)3.84450414
8neutrophil activation involved in immune response (GO:0002283)3.70490314
9positive regulation of gamma-delta T cell activation (GO:0046645)3.63116430
10detection of bacterium (GO:0016045)3.61890060
11detection of other organism (GO:0098543)3.59175501
12antigen processing and presentation via MHC class Ib (GO:0002475)3.41160983
13regulation of gamma-delta T cell activation (GO:0046643)3.39867384
14response to muramyl dipeptide (GO:0032495)3.31302271
15negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.26437362
16valine metabolic process (GO:0006573)3.17555462
17regulation of mast cell degranulation (GO:0043304)3.16707706
18pentose-phosphate shunt (GO:0006098)3.12005893
19positive regulation of histone deacetylation (GO:0031065)3.11895255
20negative regulation of erythrocyte differentiation (GO:0045647)3.02035048
21positive thymic T cell selection (GO:0045059)2.99673779
22regulation of leukocyte degranulation (GO:0043300)2.95253027
23regulation of interleukin-12 biosynthetic process (GO:0045075)2.94905157
24macrophage activation involved in immune response (GO:0002281)2.93264047
25leukocyte aggregation (GO:0070486)2.90471719
26germinal center formation (GO:0002467)2.89735296
27regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87360002
28maternal placenta development (GO:0001893)2.85693633
29morphogenesis of an endothelium (GO:0003159)2.85295816
30endothelial tube morphogenesis (GO:0061154)2.85295816
31regulation of type I interferon-mediated signaling pathway (GO:0060338)2.85111847
32detection of external biotic stimulus (GO:0098581)2.84924052
33regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83780784
34NIK/NF-kappaB signaling (GO:0038061)2.83643718
35lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83459712
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78861371
37DNA deamination (GO:0045006)2.76852857
38folic acid metabolic process (GO:0046655)2.76832411
39mature B cell differentiation involved in immune response (GO:0002313)2.73908129
40positive regulation of protein deacetylation (GO:0090312)2.72220177
41regulation of B cell receptor signaling pathway (GO:0050855)2.71980409
42regulation of mast cell activation involved in immune response (GO:0033006)2.71904637
43response to host immune response (GO:0052572)2.71008878
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.71008878
45protein localization to endosome (GO:0036010)2.67384790
46NADPH regeneration (GO:0006740)2.66659896
47natural killer cell differentiation (GO:0001779)2.64664990
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63392774
49response to host (GO:0075136)2.63392774
50response to host defenses (GO:0052200)2.63392774
51JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62030525
52positive regulation of B cell differentiation (GO:0045579)2.61972091
53amino sugar catabolic process (GO:0046348)2.60741807
54defense response to protozoan (GO:0042832)2.59528489
55modulation by symbiont of host cellular process (GO:0044068)2.58644113
56positive regulation of Cdc42 GTPase activity (GO:0043089)2.58284162
57negative regulation of leukocyte mediated immunity (GO:0002704)2.56701360
58regulation of necrotic cell death (GO:0010939)2.56568097
59interferon-gamma-mediated signaling pathway (GO:0060333)2.55897978
60mannose metabolic process (GO:0006013)2.55419121
61mitotic G1 DNA damage checkpoint (GO:0031571)2.54197602
62negative regulation of cytokine production involved in immune response (GO:0002719)2.52095587
63granulocyte activation (GO:0036230)2.51518233
64tolerance induction (GO:0002507)2.51129227
65modulation by virus of host process (GO:0019054)2.50225559
66negative regulation of stress fiber assembly (GO:0051497)2.50118419
67response to protozoan (GO:0001562)2.49999847
68response to laminar fluid shear stress (GO:0034616)2.49412086
69cellular extravasation (GO:0045123)2.47989260
70neutrophil activation (GO:0042119)2.47008925
71Arp2/3 complex-mediated actin nucleation (GO:0034314)2.44684901
72cellular response to thyroid hormone stimulus (GO:0097067)2.43847798
73myeloid cell activation involved in immune response (GO:0002275)2.43576450
74thymic T cell selection (GO:0045061)2.43005022
75regulation of antigen processing and presentation (GO:0002577)2.42867405
76detection of biotic stimulus (GO:0009595)2.42524537
77* regulation of response to interferon-gamma (GO:0060330)2.42290422
78immunoglobulin mediated immune response (GO:0016064)2.42284261
79positive regulation of antigen processing and presentation (GO:0002579)2.41040450
80regulation of T-helper 2 cell differentiation (GO:0045628)2.40069791
81formation of translation preinitiation complex (GO:0001731)2.39919882
82negative regulation of interleukin-6 production (GO:0032715)2.39859610
83apoptotic process involved in morphogenesis (GO:0060561)2.38448084
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37808543
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.37642904
86negative regulation of lymphocyte mediated immunity (GO:0002707)2.37629109
87negative regulation of nitric oxide biosynthetic process (GO:0045019)2.37453747
88regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.37084898
89regulation of defense response to virus by virus (GO:0050690)2.37074826
90folic acid-containing compound biosynthetic process (GO:0009396)2.36768126
91T cell apoptotic process (GO:0070231)2.36698256
92negative regulation of cell size (GO:0045792)2.35608854
93* regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.35177281
94glucose catabolic process (GO:0006007)2.34496412
95B cell receptor signaling pathway (GO:0050853)2.33933587
96negative regulation of interleukin-12 production (GO:0032695)2.33827171
973-UTR-mediated mRNA stabilization (GO:0070935)2.33757115
98regulation of regulated secretory pathway (GO:1903305)2.33651040
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.33119220
100regulation of interferon-beta biosynthetic process (GO:0045357)2.32496016
101regulation of translational termination (GO:0006449)2.31271501
102T cell selection (GO:0045058)2.31035783
103positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.31002154
104respiratory burst (GO:0045730)2.30610425
105tricarboxylic acid metabolic process (GO:0072350)2.30524023
106regulation of tumor necrosis factor production (GO:0032680)2.30452964
107negative regulation of tumor necrosis factor production (GO:0032720)2.30407019
108regulation of T cell mediated cytotoxicity (GO:0001914)2.30334655
109cellular hyperosmotic response (GO:0071474)2.30326022
110autophagic vacuole fusion (GO:0000046)2.29251407
111negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.28723948
112positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.28338553
113regulation of B cell differentiation (GO:0045577)2.27779492
114mitotic G1/S transition checkpoint (GO:0044819)2.25724469
115* negative regulation of innate immune response (GO:0045824)2.22405713
116pinocytosis (GO:0006907)2.22138814
117low-density lipoprotein particle clearance (GO:0034383)2.21372178
118regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.18175639
119glycine metabolic process (GO:0006544)2.17556462
120positive regulation of lamellipodium assembly (GO:0010592)2.16951240
121endothelial cell chemotaxis (GO:0035767)2.15612653
122sulfur amino acid catabolic process (GO:0000098)2.12848343
1232-oxoglutarate metabolic process (GO:0006103)2.12298185
124B cell mediated immunity (GO:0019724)2.12202969
125lymphocyte apoptotic process (GO:0070227)2.11254313
126apoptotic cell clearance (GO:0043277)2.10531624
127regulation of superoxide anion generation (GO:0032928)2.10071256
128lysine metabolic process (GO:0006553)2.09860485
129lysine catabolic process (GO:0006554)2.09860485
130regulation of translational fidelity (GO:0006450)2.09802791
131trophectodermal cell differentiation (GO:0001829)2.09348153
132nucleotide salvage (GO:0043173)2.09173525
133negative thymic T cell selection (GO:0045060)2.07883029
134response to type I interferon (GO:0034340)2.07172261
135viral transcription (GO:0019083)2.05163687
136regulation of erythrocyte differentiation (GO:0045646)2.04765690
137ribosomal small subunit assembly (GO:0000028)2.02307762
138cellular response to type I interferon (GO:0071357)2.02211871
139type I interferon signaling pathway (GO:0060337)2.02211871
140intracellular estrogen receptor signaling pathway (GO:0030520)2.01732668
141positive regulation of interferon-alpha production (GO:0032727)2.00675021
142positive regulation of natural killer cell differentiation (GO:0032825)1.99713870
143positive regulation of SMAD protein import into nucleus (GO:0060391)1.99048067
144cellular response to virus (GO:0098586)1.99032707
145negative regulation of glycoprotein biosynthetic process (GO:0010561)1.98496209
146negative T cell selection (GO:0043383)1.97972363
147positive regulation of lamellipodium organization (GO:1902745)1.97154343
148barbed-end actin filament capping (GO:0051016)1.94263671
149translational elongation (GO:0006414)1.94240098
150* regulation of cholesterol storage (GO:0010885)1.93995363
151modulation by symbiont of host defense response (GO:0052031)1.93597775
152modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.93597775
153modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.93597775
154positive regulation by organism of defense response of other organism involved in symbiotic interact1.93597775
155modulation by symbiont of host immune response (GO:0052553)1.93597775
156positive regulation by symbiont of host defense response (GO:0052509)1.93597775
157cellular response to interleukin-4 (GO:0071353)1.92757181
158COPI coating of Golgi vesicle (GO:0048205)1.92552254
159Golgi transport vesicle coating (GO:0048200)1.92552254
160cysteine metabolic process (GO:0006534)1.91892686
161translational termination (GO:0006415)1.91641047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human2.97884048
2MYC_22102868_ChIP-Seq_BL_Human2.91733541
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.83738291
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74363951
5VDR_21846776_ChIP-Seq_THP-1_Human2.38994394
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.38179767
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25259583
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21192767
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.09085916
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.06997057
11ELK3_25401928_ChIP-Seq_HUVEC_Human1.90419322
12FOXM1_23109430_ChIP-Seq_U2OS_Human1.85648557
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84687260
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83287353
15PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74812253
16TCF7_22412390_ChIP-Seq_EML_Mouse1.74478731
17MAF_26560356_Chip-Seq_TH1_Human1.72832671
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65494829
19ZNF263_19887448_ChIP-Seq_K562_Human1.65454707
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60309483
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.60156266
22UTX_26944678_Chip-Seq_JUKART_Human1.57437800
23STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55781790
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55499987
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.54865152
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53466780
27RXR_22158963_ChIP-Seq_LIVER_Mouse1.52785668
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52687536
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52531577
30KDM2B_26808549_Chip-Seq_DND41_Human1.52359333
31LXR_22292898_ChIP-Seq_THP-1_Human1.51296658
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45108813
33* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44430448
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44119637
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42916559
36PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42647700
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42081654
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41678203
39SCL_19346495_ChIP-Seq_HPC-7_Human1.40711981
40VDR_24763502_ChIP-Seq_THP-1_Human1.40093012
41GATA1_19941826_ChIP-Seq_K562_Human1.39772036
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39759670
43TET1_21451524_ChIP-Seq_MESCs_Mouse1.39615789
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.37812016
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36056567
46RACK7_27058665_Chip-Seq_MCF-7_Human1.35974116
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34869536
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33392519
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32981093
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32471092
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.32137380
52CIITA_25753668_ChIP-Seq_RAJI_Human1.31697568
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30900966
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30738682
55MAF_26560356_Chip-Seq_TH2_Human1.30490480
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28930413
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28719617
58MYB_26560356_Chip-Seq_TH1_Human1.27641794
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27370318
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.26173994
61MYB_26560356_Chip-Seq_TH2_Human1.25271436
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24764661
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24588169
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24561036
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24400193
66ATF3_27146783_Chip-Seq_COLON_Human1.24302104
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.24145917
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23648415
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23415634
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23298346
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23123312
72* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23002910
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22814655
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22711693
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21615400
76SPI1_23547873_ChIP-Seq_NB4_Human1.21586972
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21161010
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20228872
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20153175
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18211581
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18107303
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17778679
83XRN2_22483619_ChIP-Seq_HELA_Human1.17636804
84* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17302346
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16038327
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15457772
87NCOR1_26117541_ChIP-Seq_K562_Human1.13338219
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13255458
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13080313
90CLOCK_20551151_ChIP-Seq_293T_Human1.13051654
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12584697
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12167247
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12158482
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11945459
95BCL6_27268052_Chip-Seq_Bcells_Human1.11705374
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.11425522
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11349953
98* P68_20966046_ChIP-Seq_HELA_Human1.11146761
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10326243
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.09946901
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.09818855
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08681748
103SMC4_20622854_ChIP-Seq_HELA_Human1.08549262
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07998096
105* BCOR_27268052_Chip-Seq_Bcells_Human1.07905022
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07901921
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06757475
108RUNX_20019798_ChIP-Seq_JUKART_Human1.06325845
109KDM2B_26808549_Chip-Seq_K562_Human1.05656452
110MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05200003
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03997651
112DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03193099
113TFEB_21752829_ChIP-Seq_HELA_Human1.02193465
114GATA1_22025678_ChIP-Seq_K562_Human1.01521005
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01267400
116* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00987855
117IRF8_27001747_Chip-Seq_BMDM_Mouse1.00827768
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99883867
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99731224
120NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99140676
121* ETS1_20019798_ChIP-Seq_JURKAT_Human0.99108173
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98609146
123FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98158923
124KDM5A_27292631_Chip-Seq_BREAST_Human0.97719530
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96835757
126LXR_22158963_ChIP-Seq_LIVER_Mouse0.93929189
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.93513276
128CTCF_21964334_Chip-Seq_Bcells_Human0.92443568
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92108528
130SPI1_23127762_ChIP-Seq_K562_Human0.92023924
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91544033
132* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91188347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog2.72348471
2MP0005451_abnormal_body_composition2.70919144
3MP0005360_urolithiasis2.43191988
4MP0000685_abnormal_immune_system2.42605228
5MP0008260_abnormal_autophagy2.40278641
6MP0010352_gastrointestinal_tract_polyps2.29405332
7* MP0009840_abnormal_foam_cell2.09810655
8MP0003300_gastrointestinal_ulcer2.03779489
9MP0003436_decreased_susceptibility_to1.99670827
10MP0001835_abnormal_antigen_presentation1.97013063
11* MP0003191_abnormal_cellular_cholesterol1.90851924
12MP0003303_peritoneal_inflammation1.81611552
13MP0003075_altered_response_to1.78404311
14MP0003763_abnormal_thymus_physiology1.77603485
15MP0002396_abnormal_hematopoietic_system1.76366984
16MP0009333_abnormal_splenocyte_physiolog1.73567813
17MP0001853_heart_inflammation1.70854345
18MP0001800_abnormal_humoral_immune1.68591823
19* MP0001545_abnormal_hematopoietic_system1.66373175
20* MP0005397_hematopoietic_system_phenotyp1.66373175
21MP0005058_abnormal_lysosome_morphology1.63506780
22MP0003693_abnormal_embryo_hatching1.63143582
23* MP0009278_abnormal_bone_marrow1.60835823
24MP0005387_immune_system_phenotype1.59890211
25MP0001790_abnormal_immune_system1.59890211
26MP0010155_abnormal_intestine_physiology1.56321308
27MP0004947_skin_inflammation1.53896669
28MP0009785_altered_susceptibility_to1.52420879
29MP0002398_abnormal_bone_marrow1.52370144
30MP0002452_abnormal_antigen_presenting1.50476239
31MP0002998_abnormal_bone_remodeling1.49408573
32MP0005671_abnormal_response_to1.47396785
33MP0003806_abnormal_nucleotide_metabolis1.46997426
34MP0002405_respiratory_system_inflammati1.46428612
35MP0000689_abnormal_spleen_morphology1.46246452
36MP0002723_abnormal_immune_serum1.43325295
37MP0003566_abnormal_cell_adhesion1.43055585
38MP0005023_abnormal_wound_healing1.42868740
39MP0004808_abnormal_hematopoietic_stem1.42705876
40* MP0005025_abnormal_response_to1.42632157
41MP0002722_abnormal_immune_system1.42573785
42MP0005000_abnormal_immune_tolerance1.41196541
43MP0005670_abnormal_white_adipose1.40638900
44MP0005464_abnormal_platelet_physiology1.39032050
45MP0002420_abnormal_adaptive_immunity1.38334938
46MP0001819_abnormal_immune_cell1.38172986
47MP0002139_abnormal_hepatobiliary_system1.37558082
48MP0006082_CNS_inflammation1.36649151
49MP0000490_abnormal_crypts_of1.34123967
50* MP0000716_abnormal_immune_system1.32339299
51MP0003656_abnormal_erythrocyte_physiolo1.31966392
52MP0010307_abnormal_tumor_latency1.29513311
53MP0002166_altered_tumor_susceptibility1.28759861
54MP0001873_stomach_inflammation1.26465467
55MP0002877_abnormal_melanocyte_morpholog1.26244244
56* MP0002429_abnormal_blood_cell1.25045552
57MP0002419_abnormal_innate_immunity1.24706938
58MP0005166_decreased_susceptibility_to1.23467397
59* MP0000609_abnormal_liver_physiology1.22845625
60MP0005076_abnormal_cell_differentiation1.22406362
61MP0003866_abnormal_defecation1.21452919
62MP0001845_abnormal_inflammatory_respons1.19661665
63MP0003111_abnormal_nucleus_morphology1.19238656
64MP0004957_abnormal_blastocyst_morpholog1.18621833
65MP0000858_altered_metastatic_potential1.18449905
66MP0003077_abnormal_cell_cycle1.17487814
67MP0000703_abnormal_thymus_morphology1.16211261
68MP0001849_ear_inflammation1.15440349
69MP0002933_joint_inflammation1.12524575
70MP0002138_abnormal_hepatobiliary_system1.12265836
71MP0003724_increased_susceptibility_to1.11232440
72MP0008438_abnormal_cutaneous_collagen1.10123152
73MP0001851_eye_inflammation1.09770497
74MP0009643_abnormal_urine_homeostasis1.08782767
75MP0005365_abnormal_bile_salt1.08696950
76MP0000465_gastrointestinal_hemorrhage1.08601285
77MP0008469_abnormal_protein_level1.08447258
78* MP0005390_skeleton_phenotype1.08052248
79MP0005165_increased_susceptibility_to1.07304825
80MP0002019_abnormal_tumor_incidence1.06983716
81MP0003828_pulmonary_edema1.06886226
82MP0008004_abnormal_stomach_pH1.05955792
83MP0000751_myopathy1.03100386
84MP0005319_abnormal_enzyme/_coenzyme1.02949127
85MP0001958_emphysema1.02566078
86MP0008961_abnormal_basal_metabolism1.02343117
87MP0005083_abnormal_biliary_tract1.00735187
88* MP0001533_abnormal_skeleton_physiology0.98408076
89MP0002332_abnormal_exercise_endurance0.97683905
90MP0000343_altered_response_to0.97364967
91MP0003453_abnormal_keratinocyte_physiol0.96706271
92MP0004381_abnormal_hair_follicle0.95818597
93MP0002006_tumorigenesis0.95129557
94MP0003448_altered_tumor_morphology0.94898205
95* MP0000604_amyloidosis0.94252573
96MP0000598_abnormal_liver_morphology0.94231490
97MP0005666_abnormal_adipose_tissue0.94230961
98MP0003183_abnormal_peptide_metabolism0.93186501
99MP0004510_myositis0.92160988
100MP0003091_abnormal_cell_migration0.91655291
101MP0002148_abnormal_hypersensitivity_rea0.89934219
102MP0001730_embryonic_growth_arrest0.89639884
103MP0001542_abnormal_bone_strength0.88835681
104MP0005310_abnormal_salivary_gland0.88311999
105MP0002136_abnormal_kidney_physiology0.86979448
106MP0008874_decreased_physiological_sensi0.86301252
107MP0003279_aneurysm0.86141406
108MP0000350_abnormal_cell_proliferation0.85991859
109MP0000249_abnormal_blood_vessel0.85977122
110MP0002132_abnormal_respiratory_system0.85783026
111MP0010329_abnormal_lipoprotein_level0.85583519
112MP0004185_abnormal_adipocyte_glucose0.85124047
113MP0005164_abnormal_response_to0.84048990
114MP0003795_abnormal_bone_structure0.83823242
115MP0001663_abnormal_digestive_system0.83715725
116MP0003186_abnormal_redox_activity0.83273760
117MP0000747_muscle_weakness0.82548485
118MP0005085_abnormal_gallbladder_physiolo0.79654281
119MP0000750_abnormal_muscle_regeneration0.79250997
120MP0003172_abnormal_lysosome_physiology0.79021963
121MP0003252_abnormal_bile_duct0.77365791
122MP0000477_abnormal_intestine_morphology0.77272884
123MP0005332_abnormal_amino_acid0.76430495
124* MP0009763_increased_sensitivity_to0.76384598
125MP0004858_abnormal_nervous_system0.74989310
126MP0009764_decreased_sensitivity_to0.74674208
127MP0008007_abnormal_cellular_replicative0.73760891
128MP0000313_abnormal_cell_death0.72654428
129MP0001666_abnormal_nutrient_absorption0.72318135
130MP0000015_abnormal_ear_pigmentation0.72072811
131MP0004130_abnormal_muscle_cell0.70630386

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)3.85751930
2Abnormality of glycosphingolipid metabolism (HP:0004343)3.85751930
3Abnormality of glycolipid metabolism (HP:0010969)3.85751930
4Pustule (HP:0200039)3.31703954
5Abnormality of the nasal mucosa (HP:0000433)3.28888656
6Polycythemia (HP:0001901)3.17649103
7Nasal polyposis (HP:0100582)3.14620248
8Chronic otitis media (HP:0000389)3.11797220
9Distal lower limb muscle weakness (HP:0009053)3.08205092
10Eczematoid dermatitis (HP:0000976)3.04477076
11Increased cerebral lipofuscin (HP:0011813)2.88069678
12Vertebral compression fractures (HP:0002953)2.87847974
13Autoimmune thrombocytopenia (HP:0001973)2.87487281
14Orchitis (HP:0100796)2.77579423
15Stomatitis (HP:0010280)2.69363162
16Interstitial pulmonary disease (HP:0006530)2.68991656
17Elevated erythrocyte sedimentation rate (HP:0003565)2.66530156
18Amyloidosis (HP:0011034)2.64678709
19Chronic obstructive pulmonary disease (HP:0006510)2.63907698
20Obstructive lung disease (HP:0006536)2.63907698
21Purpura (HP:0000979)2.61196182
22IgM deficiency (HP:0002850)2.54767525
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.50107687
24Distal lower limb amyotrophy (HP:0008944)2.49181012
25Multiple enchondromatosis (HP:0005701)2.48515336
26Cerebral aneurysm (HP:0004944)2.48242650
27Recurrent gram-negative bacterial infections (HP:0005420)2.47688122
28Petechiae (HP:0000967)2.44696492
29Gastrointestinal inflammation (HP:0004386)2.41289207
30Centrally nucleated skeletal muscle fibers (HP:0003687)2.40943217
31Cellulitis (HP:0100658)2.39590042
32J-shaped sella turcica (HP:0002680)2.38603724
33Recurrent fungal infections (HP:0002841)2.38483140
34Thrombocytosis (HP:0001894)2.38028721
35Meningitis (HP:0001287)2.35686700
36Recurrent bronchitis (HP:0002837)2.33858271
37Increased serum ferritin (HP:0003281)2.33414470
38Recurrent viral infections (HP:0004429)2.32156091
39Hepatosplenomegaly (HP:0001433)2.30466872
40Colitis (HP:0002583)2.26694990
41Inflammation of the large intestine (HP:0002037)2.24582620
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.24462065
43Urticaria (HP:0001025)2.24234867
44Increased IgM level (HP:0003496)2.24142107
45Hypertensive crisis (HP:0100735)2.20866853
46Recurrent abscess formation (HP:0002722)2.18206884
47Agammaglobulinemia (HP:0004432)2.18039405
48Abnormality of skeletal muscle fiber size (HP:0012084)2.15772487
49Retrobulbar optic neuritis (HP:0100654)2.15389219
50Optic neuritis (HP:0100653)2.15389219
51Reduced subcutaneous adipose tissue (HP:0003758)2.14706290
52Gastrointestinal infarctions (HP:0005244)2.14565650
53Myocardial infarction (HP:0001658)2.13626563
54Gingivitis (HP:0000230)2.13038523
55Abnormal platelet function (HP:0011869)2.12174705
56Impaired platelet aggregation (HP:0003540)2.12174705
57Abnormality of T cell physiology (HP:0011840)2.09127440
58Spontaneous hematomas (HP:0007420)2.09100044
59Fatigue (HP:0012378)2.08040142
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.07718930
61Abnormal gallbladder physiology (HP:0012438)2.07710668
62Cholecystitis (HP:0001082)2.07710668
63Myopathic facies (HP:0002058)2.07685638
64Emphysema (HP:0002097)2.06575847
65Prolonged bleeding time (HP:0003010)2.05804052
66Abnormality of T cells (HP:0002843)2.05448574
67Mesangial abnormality (HP:0001966)2.04979944
68Increased variability in muscle fiber diameter (HP:0003557)2.03122424
69Vasculitis (HP:0002633)2.02724269
70Hand muscle atrophy (HP:0009130)2.02705558
71Hypergammaglobulinemia (HP:0010702)2.02004120
72Axonal loss (HP:0003447)2.01194978
73Achilles tendon contracture (HP:0001771)1.99660640
74Recurrent skin infections (HP:0001581)1.99001045
75Systemic lupus erythematosus (HP:0002725)1.98519412
76Exercise-induced myalgia (HP:0003738)1.97462718
77Abnormality of the fingertips (HP:0001211)1.97350770
78Increased IgE level (HP:0003212)1.96966402
79Gastrointestinal stroma tumor (HP:0100723)1.96483062
80Abnormality of iron homeostasis (HP:0011031)1.95226780
81Myositis (HP:0100614)1.94448563
82Hyperglycinuria (HP:0003108)1.93242670
83Abnormality of transition element cation homeostasis (HP:0011030)1.92961928
84Pulmonary infiltrates (HP:0002113)1.92375443
85Papilloma (HP:0012740)1.92066461
86Verrucae (HP:0200043)1.92066461
87Esophageal varix (HP:0002040)1.91634062
88Bulbar palsy (HP:0001283)1.90027672
89Polygenic inheritance (HP:0010982)1.90002238
90Joint stiffness (HP:0001387)1.89266384
91Panhypogammaglobulinemia (HP:0003139)1.88187975
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88095093
93Gingival bleeding (HP:0000225)1.88041303
94Xanthomatosis (HP:0000991)1.86346644
95Hemorrhage of the eye (HP:0011885)1.86327088
96Dysostosis multiplex (HP:0000943)1.86122338
97Increased connective tissue (HP:0009025)1.85763717
98Gout (HP:0001997)1.84693878
99Osteomyelitis (HP:0002754)1.84633475
100Neuronal loss in central nervous system (HP:0002529)1.84003415
101Prolonged neonatal jaundice (HP:0006579)1.83095696
102Gastrointestinal dysmotility (HP:0002579)1.82639871
103Hematochezia (HP:0002573)1.81504657
104Vacuolated lymphocytes (HP:0001922)1.81339422
105Distal upper limb amyotrophy (HP:0007149)1.81240898
106Upper limb amyotrophy (HP:0009129)1.81240898
107Chest pain (HP:0100749)1.80564939
108Encephalitis (HP:0002383)1.80485994
109Granulocytopenia (HP:0001913)1.80044384
110Abnormality of the Achilles tendon (HP:0005109)1.79508743
111Recurrent cutaneous fungal infections (HP:0011370)1.79114768
112Chronic mucocutaneous candidiasis (HP:0002728)1.79114768
113Asymmetric septal hypertrophy (HP:0001670)1.79039031
114T lymphocytopenia (HP:0005403)1.78325576
115Progressive neurologic deterioration (HP:0002344)1.78126556
116Mucopolysacchariduria (HP:0008155)1.77514684
117Urinary glycosaminoglycan excretion (HP:0003541)1.77514684
118Deep venous thrombosis (HP:0002625)1.75102885
119Rhabdomyolysis (HP:0003201)1.74855539
120Recurrent bacterial skin infections (HP:0005406)1.74811311
121Ulnar bowing (HP:0003031)1.74589961
122Spastic diplegia (HP:0001264)1.74098299
123Hyperacusis (HP:0010780)1.72637662
124Combined immunodeficiency (HP:0005387)1.72489770
125Reticulocytosis (HP:0001923)1.72414817
126Epistaxis (HP:0000421)1.71962264
127Abnormality of T cell number (HP:0011839)1.71633403
128Abnormality of macrophages (HP:0004311)1.71329124
129Abnormality of fatty-acid metabolism (HP:0004359)1.69801071
130Ankle contracture (HP:0006466)1.69339599
131Aortic aneurysm (HP:0004942)1.69050981
132Nonimmune hydrops fetalis (HP:0001790)1.68870244
133Metaphyseal cupping (HP:0003021)1.68764624
134Difficulty climbing stairs (HP:0003551)1.68371665
135Hypertriglyceridemia (HP:0002155)1.67675641
136Mediastinal lymphadenopathy (HP:0100721)1.66967523
137Chondrocalcinosis (HP:0000934)1.66003938
138Abnormal cartilage morphology (HP:0002763)1.65031288
139Aneurysm (HP:0002617)1.64973828
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64969049
141Abnormality of polysaccharide metabolism (HP:0011012)1.64969049
142Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64969049
143Osteolytic defects of the phalanges of the hand (HP:0009771)1.64921266
144Osteolytic defects of the hand bones (HP:0009699)1.64921266
145Selective tooth agenesis (HP:0001592)1.64610639
146Hypochromic anemia (HP:0001931)1.63543563
147Late onset (HP:0003584)1.62792512
148Abnormal number of erythroid precursors (HP:0012131)1.62749042
149Abnormality of cells of the erythroid lineage (HP:0012130)1.62717751
150Hypercholesterolemia (HP:0003124)1.60916330
151Abnormality of monocarboxylic acid metabolism (HP:0010996)1.60848916
152Increased density of long bones (HP:0006392)1.60676269
153Thoracic kyphosis (HP:0002942)1.60648000
154Loss of speech (HP:0002371)1.60568915
155Skin ulcer (HP:0200042)1.60079858
156Ulnar deviation of the wrist (HP:0003049)1.59567041
157Hyperammonemia (HP:0001987)1.57657328
158Trismus (HP:0000211)1.57081925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.51601094
2ERN13.47805627
3MAP4K13.38680138
4PRPF4B3.34236187
5MAP3K103.14174529
6PKN22.73428309
7EEF2K2.71253548
8RIPK42.20817108
9ZAP702.00051002
10STK101.94405059
11FGFR41.93671503
12MAP2K31.93425241
13BCKDK1.81969266
14TYK21.79963526
15BLK1.68221645
16SMG11.67157227
17GRK61.66990382
18KDR1.63934851
19LRRK21.61538323
20TBK11.61297142
21MAP3K111.59807427
22ARAF1.59223682
23TESK21.55771598
24JAK31.55624745
25TGFBR21.55274143
26CDK121.53608247
27NEK21.52183938
28EPHB11.50825026
29NME21.48235737
30MAPKAPK31.48128349
31PTK61.44986282
32SIK11.44283569
33TTN1.44000785
34MAP3K131.43287411
35FLT31.41699252
36RPS6KA41.39265184
37FES1.37084595
38PAK41.35070981
39BTK1.30434591
40PRKD21.29829895
41MAP3K11.29501073
42TNK21.27243082
43PIM21.23786895
44ICK1.20969664
45RIPK11.20552501
46BUB11.17413576
47PIM11.16167403
48TAOK11.15459436
49IKBKE1.09642192
50MAP3K81.09616731
51CDK41.06387493
52MAP3K31.04730370
53EPHA21.04579055
54RPS6KB21.04007062
55KIT1.01538539
56CHUK0.94072914
57LMTK20.93734490
58IKBKB0.93730918
59MAPK120.93058146
60SCYL20.89797462
61SIK30.87804448
62JAK10.87661359
63CSF1R0.87346711
64CSK0.83651105
65LIMK10.83564256
66WEE10.82612242
67BMX0.82436120
68MARK20.81550312
69ABL20.81059801
70PDPK10.77762110
71TAOK20.77610043
72IRAK30.77160622
73JAK20.77077035
74MAP2K20.76933399
75HIPK20.76635835
76MOS0.76106107
77MTOR0.76035243
78MAPK110.75170098
79NEK10.74050564
80CDC42BPA0.72845928
81CDK70.70919718
82ITK0.69168724
83CDK60.67975638
84MARK30.66364734
85MAPK70.65823970
86HCK0.65221677
87RPS6KL10.64670500
88RPS6KC10.64670500
89STK40.64089934
90SIK20.63194757
91LYN0.63087164
92RPS6KA20.62680282
93TGFBR10.61788931
94ALK0.60268518
95DYRK1B0.59915061
96KSR20.59635807
97DYRK30.58831290
98FGR0.57618566
99PDK10.57010327
100GRK70.56536992
101TESK10.55960699
102LCK0.55312669
103MAP3K70.55031932
104SYK0.53856093
105MAP2K60.53418259
106MATK0.51453904
107IRAK20.49454964
108TXK0.48917604
109PTK2B0.48634079
110MAP3K140.48502661
111BRAF0.48145233
112FGFR30.48007590
113TAOK30.47338698
114MAPKAPK20.46265901
115DAPK30.45636107
116EPHA30.45399227
117CAMK1D0.45106843
118MAPK40.44415550
119PRKD10.43304252
120PRKG20.42132611
121PIK3CG0.41478644
122MYLK0.41459372
123TEC0.41409214
124PTK20.40697639
125MAP3K60.40675616
126RPS6KA10.39860512
127PAK10.38512047
128TTK0.37356424
129NLK0.36709771
130ACVR1B0.35479807
131TIE10.35416104
132TSSK60.35388625
133PDGFRA0.35216597
134EIF2AK10.35043659
135IRAK40.34588814
136ILK0.34272427
137PAK20.34224916
138MST40.33627029
139RPS6KA60.33509115

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.10412907
2Sulfur relay system_Homo sapiens_hsa041222.04706981
3Primary immunodeficiency_Homo sapiens_hsa053402.00056189
4Autoimmune thyroid disease_Homo sapiens_hsa053201.88998349
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86340725
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84648153
7Malaria_Homo sapiens_hsa051441.83567152
8Graft-versus-host disease_Homo sapiens_hsa053321.83354519
9DNA replication_Homo sapiens_hsa030301.74950533
10Leishmaniasis_Homo sapiens_hsa051401.67346171
11Pentose phosphate pathway_Homo sapiens_hsa000301.60899554
12Antigen processing and presentation_Homo sapiens_hsa046121.60299215
13Folate biosynthesis_Homo sapiens_hsa007901.59763593
14B cell receptor signaling pathway_Homo sapiens_hsa046621.50682366
15Staphylococcus aureus infection_Homo sapiens_hsa051501.45662328
16Acute myeloid leukemia_Homo sapiens_hsa052211.45189315
17Base excision repair_Homo sapiens_hsa034101.41740030
18Asthma_Homo sapiens_hsa053101.41635799
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39904187
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.36657275
21Other glycan degradation_Homo sapiens_hsa005111.31272674
22Osteoclast differentiation_Homo sapiens_hsa043801.30019383
23Biosynthesis of amino acids_Homo sapiens_hsa012301.29423531
24Chronic myeloid leukemia_Homo sapiens_hsa052201.29303306
25Rheumatoid arthritis_Homo sapiens_hsa053231.28533631
26Measles_Homo sapiens_hsa051621.25777699
27Legionellosis_Homo sapiens_hsa051341.24958508
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23274410
29Herpes simplex infection_Homo sapiens_hsa051681.21080658
30Fatty acid degradation_Homo sapiens_hsa000711.20267522
31Selenocompound metabolism_Homo sapiens_hsa004501.19366315
32Toxoplasmosis_Homo sapiens_hsa051451.17896512
33Phagosome_Homo sapiens_hsa041451.17557099
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17372393
35Carbon metabolism_Homo sapiens_hsa012001.16401275
36Apoptosis_Homo sapiens_hsa042101.13737551
37Caffeine metabolism_Homo sapiens_hsa002321.13550625
38Hepatitis C_Homo sapiens_hsa051601.13477402
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13223641
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12047151
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.09771908
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.09438346
43Salmonella infection_Homo sapiens_hsa051321.07359982
44Small cell lung cancer_Homo sapiens_hsa052221.06949675
45Type I diabetes mellitus_Homo sapiens_hsa049401.06635154
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.06419526
47p53 signaling pathway_Homo sapiens_hsa041151.03629012
48Non-small cell lung cancer_Homo sapiens_hsa052231.02585771
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.00784840
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00163394
51Influenza A_Homo sapiens_hsa051641.00151826
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99536224
53Shigellosis_Homo sapiens_hsa051310.99193185
54Ribosome_Homo sapiens_hsa030100.98015221
55Notch signaling pathway_Homo sapiens_hsa043300.97889573
56One carbon pool by folate_Homo sapiens_hsa006700.97317917
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96881490
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96218980
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96098826
60Chemokine signaling pathway_Homo sapiens_hsa040620.95694204
61Fructose and mannose metabolism_Homo sapiens_hsa000510.94306391
62Lysosome_Homo sapiens_hsa041420.93965726
63Endocytosis_Homo sapiens_hsa041440.93288185
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93238270
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.92809101
66Lysine degradation_Homo sapiens_hsa003100.91990124
67Platelet activation_Homo sapiens_hsa046110.91833540
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90963626
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90939192
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.90517076
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90334022
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.90227599
73Galactose metabolism_Homo sapiens_hsa000520.89912381
74Mismatch repair_Homo sapiens_hsa034300.89422723
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88437627
76Spliceosome_Homo sapiens_hsa030400.88273950
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87182113
78RNA transport_Homo sapiens_hsa030130.87109483
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86133684
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.85156199
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85046609
82T cell receptor signaling pathway_Homo sapiens_hsa046600.83924421
83Hematopoietic cell lineage_Homo sapiens_hsa046400.83843587
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83817543
85PPAR signaling pathway_Homo sapiens_hsa033200.82919436
86Epstein-Barr virus infection_Homo sapiens_hsa051690.82378245
87Prion diseases_Homo sapiens_hsa050200.81958009
88Viral myocarditis_Homo sapiens_hsa054160.80358311
89Amoebiasis_Homo sapiens_hsa051460.79099265
90African trypanosomiasis_Homo sapiens_hsa051430.78766227
91HTLV-I infection_Homo sapiens_hsa051660.78357152
92Arginine biosynthesis_Homo sapiens_hsa002200.76358669
93Bladder cancer_Homo sapiens_hsa052190.74938673
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.74543154
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74238456
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73790945
97Hepatitis B_Homo sapiens_hsa051610.73343814
98Fat digestion and absorption_Homo sapiens_hsa049750.72263883
99Viral carcinogenesis_Homo sapiens_hsa052030.71746449
100Pertussis_Homo sapiens_hsa051330.71462309
101TNF signaling pathway_Homo sapiens_hsa046680.71138555
102* Insulin resistance_Homo sapiens_hsa049310.69750007
103Pancreatic cancer_Homo sapiens_hsa052120.67185124
104mTOR signaling pathway_Homo sapiens_hsa041500.66860334
105Cell cycle_Homo sapiens_hsa041100.66561094
106Complement and coagulation cascades_Homo sapiens_hsa046100.66324377
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66014954
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65391926
109Nitrogen metabolism_Homo sapiens_hsa009100.64451011
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64007479
111Tryptophan metabolism_Homo sapiens_hsa003800.63134756
112Tuberculosis_Homo sapiens_hsa051520.63058637
113HIF-1 signaling pathway_Homo sapiens_hsa040660.61642343
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60410358
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59744175
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.59085672
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.58999461
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58168882
119ABC transporters_Homo sapiens_hsa020100.57994152
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57261958
121Pyrimidine metabolism_Homo sapiens_hsa002400.56267721
122VEGF signaling pathway_Homo sapiens_hsa043700.55995495
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55682802
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55369758
125beta-Alanine metabolism_Homo sapiens_hsa004100.55057424
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.54981975
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54040471
128Insulin signaling pathway_Homo sapiens_hsa049100.53719503
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.53623235
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.50946677
131GnRH signaling pathway_Homo sapiens_hsa049120.50190383
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48546939
133Renal cell carcinoma_Homo sapiens_hsa052110.48282596
134Vibrio cholerae infection_Homo sapiens_hsa051100.47267979
135Prolactin signaling pathway_Homo sapiens_hsa049170.42815209
136Endometrial cancer_Homo sapiens_hsa052130.41511324
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40298639
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40270175
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39979763
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33586234

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