NR1H3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.05074732
2L-phenylalanine catabolic process (GO:0006559)7.05074732
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.81470719
4L-phenylalanine metabolic process (GO:0006558)6.81470719
5aromatic amino acid family catabolic process (GO:0009074)6.28552613
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.05050421
7alpha-linolenic acid metabolic process (GO:0036109)5.68744879
8tryptophan catabolic process (GO:0006569)5.61312124
9indole-containing compound catabolic process (GO:0042436)5.61312124
10indolalkylamine catabolic process (GO:0046218)5.61312124
11glycosphingolipid catabolic process (GO:0046479)5.54091303
12kynurenine metabolic process (GO:0070189)5.47584452
13urea cycle (GO:0000050)5.46558366
14urea metabolic process (GO:0019627)5.46558366
15bile acid biosynthetic process (GO:0006699)5.41751246
16glyoxylate metabolic process (GO:0046487)5.40124787
17tryptophan metabolic process (GO:0006568)5.30383061
18oligosaccharide catabolic process (GO:0009313)5.28554532
19cysteine metabolic process (GO:0006534)5.24224112
20sulfur amino acid catabolic process (GO:0000098)5.17458542
21complement activation, alternative pathway (GO:0006957)5.15318445
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.14023287
23high-density lipoprotein particle remodeling (GO:0034375)5.08642559
24negative regulation of fibrinolysis (GO:0051918)5.07273798
25nitrogen cycle metabolic process (GO:0071941)5.02443514
26protein carboxylation (GO:0018214)5.00937180
27peptidyl-glutamic acid carboxylation (GO:0017187)5.00937180
28glycolipid catabolic process (GO:0019377)5.00384783
29regulation of protein activation cascade (GO:2000257)4.90462277
30serine family amino acid catabolic process (GO:0009071)4.88187816
31regulation of fibrinolysis (GO:0051917)4.84231426
32regulation of triglyceride catabolic process (GO:0010896)4.81118559
33regulation of mononuclear cell migration (GO:0071675)4.68340994
34bile acid metabolic process (GO:0008206)4.67405156
35lysine metabolic process (GO:0006553)4.62357282
36lysine catabolic process (GO:0006554)4.62357282
37amino-acid betaine metabolic process (GO:0006577)4.62036351
38regulation of complement activation (GO:0030449)4.60760921
39homocysteine metabolic process (GO:0050667)4.60219557
40aromatic amino acid family metabolic process (GO:0009072)4.56980524
41plasma lipoprotein particle clearance (GO:0034381)4.56550508
42regulation of cholesterol esterification (GO:0010872)4.53890868
43cellular response to thyroid hormone stimulus (GO:0097067)4.50855410
44reverse cholesterol transport (GO:0043691)4.50502683
45* acylglycerol homeostasis (GO:0055090)4.47718661
46* triglyceride homeostasis (GO:0070328)4.47718661
47amino sugar catabolic process (GO:0046348)4.46885753
48plasma lipoprotein particle remodeling (GO:0034369)4.44415735
49protein-lipid complex remodeling (GO:0034368)4.44415735
50macromolecular complex remodeling (GO:0034367)4.44415735
51ceramide catabolic process (GO:0046514)4.43547062
52tyrosine metabolic process (GO:0006570)4.40983404
53alpha-amino acid catabolic process (GO:1901606)4.36792559
54fat-soluble vitamin biosynthetic process (GO:0042362)4.31207051
55phospholipid efflux (GO:0033700)4.30519262
56negative regulation of interleukin-12 production (GO:0032695)4.28933279
57negative regulation of cholesterol transport (GO:0032375)4.16182791
58negative regulation of sterol transport (GO:0032372)4.16182791
59cellular ketone body metabolic process (GO:0046950)4.13601816
60dicarboxylic acid biosynthetic process (GO:0043650)4.10438347
61glutamate metabolic process (GO:0006536)4.10423907
62cellular amino acid catabolic process (GO:0009063)4.07086728
63coenzyme catabolic process (GO:0009109)4.03586174
64glycine metabolic process (GO:0006544)4.01672442
65bile acid and bile salt transport (GO:0015721)3.97083069
66indolalkylamine metabolic process (GO:0006586)3.94678983
67cholesterol efflux (GO:0033344)3.94364040
68response to peptidoglycan (GO:0032494)3.93005426
69low-density lipoprotein particle clearance (GO:0034383)3.92722205
70serine family amino acid metabolic process (GO:0009069)3.92245811
71ethanol oxidation (GO:0006069)3.86548501
72positive regulation of lipid catabolic process (GO:0050996)3.86186618
73* regulation of cholesterol storage (GO:0010885)3.82992113
74plasma lipoprotein particle assembly (GO:0034377)3.82831438
75cellular modified amino acid catabolic process (GO:0042219)3.82650246
76cellular biogenic amine catabolic process (GO:0042402)3.82635927
77amine catabolic process (GO:0009310)3.82635927
78fatty acid beta-oxidation (GO:0006635)3.81870086
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.81587377
80cellular glucuronidation (GO:0052695)3.80454462
81membrane lipid catabolic process (GO:0046466)3.77426730
82benzene-containing compound metabolic process (GO:0042537)3.76818325
83arginine metabolic process (GO:0006525)3.76108617
84acetyl-CoA metabolic process (GO:0006084)3.75711878
85fatty acid oxidation (GO:0019395)3.74146291
86imidazole-containing compound metabolic process (GO:0052803)3.72988808
87aldehyde catabolic process (GO:0046185)3.72894256
88drug catabolic process (GO:0042737)3.72858915
89response to thyroid hormone (GO:0097066)3.72580959
90organic acid catabolic process (GO:0016054)3.71851316
91carboxylic acid catabolic process (GO:0046395)3.71851316
92regulation of macrophage chemotaxis (GO:0010758)3.71762907
93sphingolipid catabolic process (GO:0030149)3.71407930
94short-chain fatty acid metabolic process (GO:0046459)3.70714594
95phospholipid homeostasis (GO:0055091)3.69026676
96lipid oxidation (GO:0034440)3.67635963
97negative regulation of lipase activity (GO:0060192)3.64104208
98carnitine metabolic process (GO:0009437)3.63339288
99monocarboxylic acid catabolic process (GO:0072329)3.63000146
100fibrinolysis (GO:0042730)3.62895168
101cofactor catabolic process (GO:0051187)3.62859956
102fatty acid catabolic process (GO:0009062)3.62719378
103positive regulation of fatty acid beta-oxidation (GO:0032000)3.61731241
104serine family amino acid biosynthetic process (GO:0009070)3.60844423
105* cholesterol homeostasis (GO:0042632)3.60050260
1062-oxoglutarate metabolic process (GO:0006103)3.59805948
107very-low-density lipoprotein particle assembly (GO:0034379)3.59154129
108neutrophil activation involved in immune response (GO:0002283)3.59063443
109valine metabolic process (GO:0006573)3.58937192
110low-density lipoprotein particle remodeling (GO:0034374)3.58904026
111immunoglobulin mediated immune response (GO:0016064)3.58848016
112ketone body metabolic process (GO:1902224)3.55373121
113* sterol homeostasis (GO:0055092)3.54539835
114complement activation, classical pathway (GO:0006958)3.54126987
115complement activation (GO:0006956)3.53894847
116blood coagulation, intrinsic pathway (GO:0007597)3.49986917
117* positive regulation of triglyceride lipase activity (GO:0061365)3.48847675
118* positive regulation of lipoprotein lipase activity (GO:0051006)3.48847675
119protein activation cascade (GO:0072376)3.48500865
120negative regulation of nitric oxide biosynthetic process (GO:0045019)3.42287208
121barbed-end actin filament capping (GO:0051016)3.41251335
122lipopolysaccharide-mediated signaling pathway (GO:0031663)3.37839776
123regulation of vitamin D biosynthetic process (GO:0060556)3.33562295
124positive regulation of monocyte chemotaxis (GO:0090026)3.32459871
125myeloid dendritic cell differentiation (GO:0043011)3.32205850
126T-helper 1 type immune response (GO:0042088)3.32169246
127positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.29227948
128angiotensin maturation (GO:0002003)3.22262352
129eosinophil chemotaxis (GO:0048245)3.20139802
130regulation of cytokine secretion involved in immune response (GO:0002739)3.18608954
131positive regulation of antigen processing and presentation (GO:0002579)3.18162079
132N-acetylneuraminate metabolic process (GO:0006054)3.17320177
133regulation of vitamin metabolic process (GO:0030656)3.08570720
134virion attachment to host cell (GO:0019062)3.06403107
135adhesion of symbiont to host cell (GO:0044650)3.06403107
136NIK/NF-kappaB signaling (GO:0038061)3.05862694
137monocyte chemotaxis (GO:0002548)3.04724292
138regulation of podosome assembly (GO:0071801)3.02199867
139macrophage activation involved in immune response (GO:0002281)3.01747575
140myeloid dendritic cell activation (GO:0001773)2.93943750
141positive regulation of chemokine biosynthetic process (GO:0045080)2.91980185
142regulation of antigen processing and presentation (GO:0002577)2.88318175
143macrophage differentiation (GO:0030225)2.83927002
144eosinophil migration (GO:0072677)2.83312840
145positive regulation of gamma-delta T cell activation (GO:0046645)2.82481934
146hydrogen peroxide biosynthetic process (GO:0050665)2.82396083
147negative regulation of myeloid cell apoptotic process (GO:0033033)2.82325134
148regulation of superoxide anion generation (GO:0032928)2.81406937
149adhesion of symbiont to host (GO:0044406)2.80676183
150interferon-gamma-mediated signaling pathway (GO:0060333)2.79261780
151regulation of membrane protein ectodomain proteolysis (GO:0051043)2.79121877
152regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78733267
153cellular response to cadmium ion (GO:0071276)2.78352912
154pinocytosis (GO:0006907)2.77797681
155regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76321431
156regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.75799615
157regulation of monocyte chemotaxis (GO:0090025)2.74338556
158dendritic cell differentiation (GO:0097028)2.73997787
159regulation of T-helper 1 cell differentiation (GO:0045625)2.73690654
160positive regulation of cellular amide metabolic process (GO:0034250)2.73326977
161detection of molecule of bacterial origin (GO:0032490)2.72407790
162lipid storage (GO:0019915)2.71205958
163negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.70845170
164vitamin D metabolic process (GO:0042359)2.69746294
165positive regulation of lipid storage (GO:0010884)2.69234340
166* positive regulation of cholesterol efflux (GO:0010875)2.63218366
167regulation of mast cell degranulation (GO:0043304)2.62003460
168positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.60598891
169keratan sulfate catabolic process (GO:0042340)2.60456478
170cellular response to zinc ion (GO:0071294)2.59872240
171negative regulation of cytokine production involved in immune response (GO:0002719)2.59865236
172phagosome maturation (GO:0090382)2.56503373
173peptide catabolic process (GO:0043171)2.56152116
174positive regulation of leukocyte degranulation (GO:0043302)2.53636404
175cellular response to arsenic-containing substance (GO:0071243)2.52836207
176regulation of chemokine biosynthetic process (GO:0045073)2.51610568
177B cell mediated immunity (GO:0019724)2.51334901
178lysosome organization (GO:0007040)2.50688731
179lytic vacuole organization (GO:0080171)2.50688731
180reactive oxygen species biosynthetic process (GO:1903409)2.50020025
181germinal center formation (GO:0002467)2.46562026
182protein-lipid complex assembly (GO:0065005)2.45194252
183positive regulation of tissue remodeling (GO:0034105)2.44767361
184plasma lipoprotein particle organization (GO:0071827)2.43263970
185lymphocyte chemotaxis (GO:0048247)2.43214348
186granulocyte activation (GO:0036230)2.43068214
187regulation of monocyte differentiation (GO:0045655)2.42293081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.89783920
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.82907680
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.31610520
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.18426398
5* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.15949875
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.03361022
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.74092921
8BP1_19119308_ChIP-ChIP_Hs578T_Human4.07224618
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.79199757
10* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.63029705
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.60445328
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26306778
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22034665
14VDR_21846776_ChIP-Seq_THP-1_Human2.16882548
15CLOCK_20551151_ChIP-Seq_293T_Human2.15858350
16VDR_24763502_ChIP-Seq_THP-1_Human2.08480839
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1040656
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98765262
19GATA1_22025678_ChIP-Seq_K562_Human1.98722206
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96654359
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96461084
22* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95647520
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93072625
24VDR_24787735_ChIP-Seq_THP-1_Human1.87809988
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77259222
26* SPI1_23127762_ChIP-Seq_K562_Human1.73108462
27SPI1_23547873_ChIP-Seq_NB4_Human1.69750407
28* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69104437
29* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64646221
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64055334
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.62720963
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59371251
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56825929
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.53509528
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52620392
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.46950363
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46365664
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46278776
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45946769
40* IRF8_22096565_ChIP-ChIP_GC-B_Human1.45323612
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44671847
42SCL_19346495_ChIP-Seq_HPC-7_Human1.37253073
43* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35510996
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34620245
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33725214
46HNF4A_19822575_ChIP-Seq_HepG2_Human1.33284445
47SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31591696
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28727559
49PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26774073
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26437101
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25730178
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25041958
53BCL6_27268052_Chip-Seq_Bcells_Human1.24479674
54CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23659069
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.22515633
56TFEB_21752829_ChIP-Seq_HELA_Human1.21339519
57PU_27001747_Chip-Seq_BMDM_Mouse1.20831334
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20319207
59HTT_18923047_ChIP-ChIP_STHdh_Human1.19574072
60STAT1_20625510_ChIP-Seq_HELA_Human1.18757568
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17884968
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13462303
63* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13007041
64MAF_26560356_Chip-Seq_TH1_Human1.11367971
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10257472
66RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08190095
67RACK7_27058665_Chip-Seq_MCF-7_Human1.07730211
68* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06821331
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03467469
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.03068434
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02428131
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01049508
73* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00541422
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00003278
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99820229
76GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97070077
77* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96950342
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96345744
79KDM2B_26808549_Chip-Seq_DND41_Human0.94436947
80TCF7_22412390_ChIP-Seq_EML_Mouse0.92800941
81GATA4_25053715_ChIP-Seq_YYC3_Human0.92766634
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92432085
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92182781
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92018118
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91172892
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88939164
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88512280
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88278246
89UTX_26944678_Chip-Seq_JUKART_Human0.87545900
90MAF_26560356_Chip-Seq_TH2_Human0.87245265
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87179094
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86548623
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85674431
94CTCF_26484167_Chip-Seq_Bcells_Mouse0.85144259
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85109702
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.80877431
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79835197
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78286509
99ZNF263_19887448_ChIP-Seq_K562_Human0.76346494
100SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75211664
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73957945
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73242220
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73242220
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72712247
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71539028
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70894919
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70599304
108* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70441020
109KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69623230
110RARA_24833708_ChIP-Seq_LIVER_Mouse0.68835104
111* LXR_22292898_ChIP-Seq_THP-1_Human0.67485116
112PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.67475634
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.65800707
114GATA1_19941826_ChIP-Seq_K562_Human0.64701829
115* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.63969332
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63919159
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62954813
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.62870485
119RARB_24833708_ChIP-Seq_LIVER_Mouse0.62157305
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61857357
121RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61114861
122GATA2_19941826_ChIP-Seq_K562_Human0.61110912
123IRF8_27001747_Chip-Seq_BMDM_Mouse0.60282251
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.58643962
125CEBPB_22108803_ChIP-Seq_LS180_Human0.58513712
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.57373892
127AR_20517297_ChIP-Seq_VCAP_Human0.56899572
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.55036614
129GATA6_25053715_ChIP-Seq_YYC3_Human0.52890600
130BRD4_27068464_Chip-Seq_AML-cells_Mouse0.51952266
131FOXA1_25552417_ChIP-Seq_VCAP_Human0.51668883
132EGR1_19032775_ChIP-ChIP_M12_Human0.51335727
133CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.51188696
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.50538937
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50283567
136MYC_19915707_ChIP-ChIP_AK7_Human0.49905945
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49230317
138P53_21459846_ChIP-Seq_SAOS-2_Human0.49037016
139STAT1_17558387_ChIP-Seq_HELA_Human0.49015220
140CDX2_20551321_ChIP-Seq_CACO-2_Human0.48816478
141NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.48046011
142GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.47731250
143* SOX2_20726797_ChIP-Seq_SW620_Human0.46552850
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.46333275
145TAF2_19829295_ChIP-Seq_ESCs_Human0.45826970
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.45648868
147BCOR_27268052_Chip-Seq_Bcells_Human0.45269847
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45201823
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.44396760
150SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43930696
151IRF8_21731497_ChIP-ChIP_J774_Mouse0.43075434
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.42427026
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.42147526
154CBP_21632823_ChIP-Seq_H3396_Human0.41684203
155* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41310424
156* ESET_19884257_ChIP-Seq_ESCs_Mouse0.40697632
157TBX20_22080862_ChIP-Seq_HEART_Mouse0.40665130
158TBX20_22328084_ChIP-Seq_HEART_Mouse0.40665130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002139_abnormal_hepatobiliary_system7.94180482
2MP0005360_urolithiasis7.19644021
3MP0005085_abnormal_gallbladder_physiolo5.79223635
4* MP0005365_abnormal_bile_salt5.77904592
5MP0008875_abnormal_xenobiotic_pharmacok4.73217754
6MP0003806_abnormal_nucleotide_metabolis3.93952780
7* MP0010329_abnormal_lipoprotein_level3.60685208
8MP0003252_abnormal_bile_duct3.56914000
9MP0003303_peritoneal_inflammation3.35741242
10MP0009840_abnormal_foam_cell3.32114861
11MP0002148_abnormal_hypersensitivity_rea3.07693857
12MP0005332_abnormal_amino_acid2.86133943
13MP0005083_abnormal_biliary_tract2.84535596
14MP0003172_abnormal_lysosome_physiology2.80675610
15MP0003195_calcinosis2.71742760
16MP0000343_altered_response_to2.55829224
17MP0001666_abnormal_nutrient_absorption2.55642482
18MP0001835_abnormal_antigen_presentation2.38731312
19* MP0000609_abnormal_liver_physiology2.26260974
20* MP0002118_abnormal_lipid_homeostasis2.23402477
21* MP0003191_abnormal_cellular_cholesterol2.15352828
22MP0004510_myositis2.13587201
23MP0004019_abnormal_vitamin_homeostasis2.13462888
24MP0005387_immune_system_phenotype2.11969641
25MP0001790_abnormal_immune_system2.11969641
26MP0005000_abnormal_immune_tolerance2.06333820
27MP0005671_abnormal_response_to2.04259194
28MP0002138_abnormal_hepatobiliary_system2.02280508
29* MP0005319_abnormal_enzyme/_coenzyme1.93031578
30MP0009278_abnormal_bone_marrow1.86535523
31MP0001533_abnormal_skeleton_physiology1.85167006
32MP0002998_abnormal_bone_remodeling1.82645715
33MP0002452_abnormal_antigen_presenting1.78664720
34MP0003300_gastrointestinal_ulcer1.76288374
35MP0001764_abnormal_homeostasis1.72694178
36MP0005397_hematopoietic_system_phenotyp1.68176555
37MP0001545_abnormal_hematopoietic_system1.68176555
38MP0003868_abnormal_feces_composition1.66151356
39MP0005584_abnormal_enzyme/coenzyme_acti1.62480058
40MP0005670_abnormal_white_adipose1.62105868
41MP0002723_abnormal_immune_serum1.61838464
42MP0003186_abnormal_redox_activity1.55049778
43MP0001800_abnormal_humoral_immune1.49830697
44MP0009643_abnormal_urine_homeostasis1.45730806
45MP0010155_abnormal_intestine_physiology1.45126304
46MP0005310_abnormal_salivary_gland1.43196987
47MP0005451_abnormal_body_composition1.41433356
48MP0003448_altered_tumor_morphology1.40203448
49MP0003453_abnormal_keratinocyte_physiol1.36848300
50MP0002405_respiratory_system_inflammati1.36294111
51MP0001819_abnormal_immune_cell1.35687504
52MP0002420_abnormal_adaptive_immunity1.35372265
53MP0004947_skin_inflammation1.33898878
54MP0000858_altered_metastatic_potential1.31476279
55MP0009697_abnormal_copulation1.29045886
56MP0004130_abnormal_muscle_cell1.27753270
57MP0003656_abnormal_erythrocyte_physiolo1.25479855
58MP0003705_abnormal_hypodermis_morpholog1.24085904
59MP0003011_delayed_dark_adaptation1.22393290
60* MP0000598_abnormal_liver_morphology1.17628458
61MP0006054_spinal_hemorrhage1.17114560
62MP0009333_abnormal_splenocyte_physiolog1.16435993
63MP0009764_decreased_sensitivity_to1.10995464
64MP0002876_abnormal_thyroid_physiology1.10149938
65* MP0008469_abnormal_protein_level1.08737182
66MP0005636_abnormal_mineral_homeostasis1.06496481
67MP0002971_abnormal_brown_adipose1.06337986
68MP0000920_abnormal_myelination1.02874416
69MP0003828_pulmonary_edema1.02402339
70* MP0009763_increased_sensitivity_to1.02198951
71MP0006036_abnormal_mitochondrial_physio1.01704459
72MP0003724_increased_susceptibility_to1.00803825
73MP0005666_abnormal_adipose_tissue1.00407580
74MP0002254_reproductive_system_inflammat0.97657461
75MP0002078_abnormal_glucose_homeostasis0.96494149
76* MP0009642_abnormal_blood_homeostasis0.94610791
77MP0008260_abnormal_autophagy0.94310422
78MP0003183_abnormal_peptide_metabolism0.92828537
79MP0005165_increased_susceptibility_to0.92749397
80MP0004883_abnormal_blood_vessel0.92721882
81MP0005535_abnormal_body_temperature0.91590400
82MP0005334_abnormal_fat_pad0.91455685
83MP0010368_abnormal_lymphatic_system0.88961012
84MP0000716_abnormal_immune_system0.88720842
85* MP0000604_amyloidosis0.88538147
86MP0005058_abnormal_lysosome_morphology0.88003152
87MP0002837_dystrophic_cardiac_calcinosis0.86486753
88MP0001661_extended_life_span0.83949991
89* MP0005647_abnormal_sex_gland0.82985812
90MP0001756_abnormal_urination0.82166700
91MP0005084_abnormal_gallbladder_morpholo0.82012395
92MP0001853_heart_inflammation0.81402101
93MP0003279_aneurysm0.80630486
94MP0008004_abnormal_stomach_pH0.79875054
95MP0005376_homeostasis/metabolism_phenot0.79858900
96MP0003690_abnormal_glial_cell0.79410348
97MP0003795_abnormal_bone_structure0.78462646
98MP0005390_skeleton_phenotype0.78278091
99MP0005257_abnormal_intraocular_pressure0.78147466
100* MP0003329_amyloid_beta_deposits0.77239848
101MP0005448_abnormal_energy_balance0.76985984
102MP0005408_hypopigmentation0.74313226
103MP0002933_joint_inflammation0.73071269
104MP0001663_abnormal_digestive_system0.72877017
105MP0005595_abnormal_vascular_smooth0.71429487
106MP0009765_abnormal_xenobiotic_induced0.70552301
107MP0002090_abnormal_vision0.70389612
108MP0005023_abnormal_wound_healing0.70162144
109MP0003634_abnormal_glial_cell0.69683315
110MP0004782_abnormal_surfactant_physiolog0.67679730
111MP0003436_decreased_susceptibility_to0.67370065
112MP0005220_abnormal_exocrine_pancreas0.67290236
113MP0002136_abnormal_kidney_physiology0.63757286
114MP0005464_abnormal_platelet_physiology0.63531167
115MP0005266_abnormal_metabolism0.63196091
116MP0004185_abnormal_adipocyte_glucose0.61432688
117MP0009115_abnormal_fat_cell0.61354396
118MP0006035_abnormal_mitochondrial_morpho0.58091501
119MP0003075_altered_response_to0.55239373
120MP0005375_adipose_tissue_phenotype0.51174402
121MP0005167_abnormal_blood-brain_barrier0.51088538
122MP0002970_abnormal_white_adipose0.49555083
123* MP0003953_abnormal_hormone_level0.48163642
124MP0008873_increased_physiological_sensi0.47054594
125MP0000639_abnormal_adrenal_gland0.46958571
126MP0005395_other_phenotype0.46769020
127* MP0001845_abnormal_inflammatory_respons0.45309822
128MP0006082_CNS_inflammation0.43462945
129MP0005166_decreased_susceptibility_to0.43087866
130MP0000230_abnormal_systemic_arterial0.42483433
131MP0003638_abnormal_response/metabolism_0.41013443
132* MP0000249_abnormal_blood_vessel0.40352252
133MP0000685_abnormal_immune_system0.39074893
134MP0002168_other_aberrant_phenotype0.38904184
135MP0004043_abnormal_pH_regulation0.38862816
136MP0002928_abnormal_bile_duct0.37000996
137MP0002796_impaired_skin_barrier0.36873668
138MP0001881_abnormal_mammary_gland0.36494991
139MP0009053_abnormal_anal_canal0.35438637
140MP0008874_decreased_physiological_sensi0.34938986
141MP0005164_abnormal_response_to0.34850004
142MP0002419_abnormal_innate_immunity0.32808074
143MP0009785_altered_susceptibility_to0.32073960
144MP0003959_abnormal_lean_body0.32063654
145MP0003718_maternal_effect0.31926580
146MP0009672_abnormal_birth_weight0.31891282
147MP0002135_abnormal_kidney_morphology0.30082443
148* MP0005025_abnormal_response_to0.29906313
149MP0001765_abnormal_ion_homeostasis0.29286031

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)8.34867567
2Abnormality of glycosphingolipid metabolism (HP:0004343)8.34867567
3Abnormality of glycolipid metabolism (HP:0010969)8.34867567
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.74952174
5Deep venous thrombosis (HP:0002625)6.53022241
6Intrahepatic cholestasis (HP:0001406)6.33294206
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.96251407
8Xanthomatosis (HP:0000991)5.89980586
9Prolonged partial thromboplastin time (HP:0003645)5.83311423
10Hypobetalipoproteinemia (HP:0003563)5.61148161
11Vacuolated lymphocytes (HP:0001922)5.37440887
12Complement deficiency (HP:0004431)5.33086614
13Increased cerebral lipofuscin (HP:0011813)5.29970324
14Hyperlipoproteinemia (HP:0010980)5.20707209
15Dysostosis multiplex (HP:0000943)4.73191295
16Hyperglycinuria (HP:0003108)4.61950551
17Hyperammonemia (HP:0001987)4.49452337
18Joint hemorrhage (HP:0005261)4.46385623
19Hyperglycinemia (HP:0002154)4.44406291
20Abnormality of macrophages (HP:0004311)4.39366745
21Hypolipoproteinemia (HP:0010981)4.38115020
22Loss of speech (HP:0002371)4.37530288
23Increased neuronal autofluorescent lipopigment (HP:0002074)4.35898882
24Ketosis (HP:0001946)4.31583596
25Abnormality of glycine metabolism (HP:0010895)4.31348716
26Abnormality of serine family amino acid metabolism (HP:0010894)4.31348716
27Abnormality of the common coagulation pathway (HP:0010990)4.28801983
28Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16479988
29Epidermoid cyst (HP:0200040)4.15602669
30Disinhibition (HP:0000734)4.10553243
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.09315829
32Hypoglycemic coma (HP:0001325)4.05491149
33Hypoalphalipoproteinemia (HP:0003233)3.98044816
34Abnormality of complement system (HP:0005339)3.89860032
35Abnormality of sulfur amino acid metabolism (HP:0004339)3.88966434
36Abnormality of the intrinsic pathway (HP:0010989)3.82094610
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.81625143
38Abnormality of fatty-acid metabolism (HP:0004359)3.80928956
39Abnormality of mucopolysaccharide metabolism (HP:0011020)3.79921447
40Abnormality of polysaccharide metabolism (HP:0011012)3.79921447
41Abnormality of glycosaminoglycan metabolism (HP:0004371)3.79921447
42Mutism (HP:0002300)3.76275594
43Axonal loss (HP:0003447)3.73070564
44Abnormality of methionine metabolism (HP:0010901)3.72095292
45Fat malabsorption (HP:0002630)3.69700436
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.64239156
47Eczematoid dermatitis (HP:0000976)3.63461036
48Urinary glycosaminoglycan excretion (HP:0003541)3.62366273
49Mucopolysacchariduria (HP:0008155)3.62366273
50Neurofibrillary tangles (HP:0002185)3.59228886
51Recurrent bacterial skin infections (HP:0005406)3.49248100
52Recurrent abscess formation (HP:0002722)3.47574734
53Hypercholesterolemia (HP:0003124)3.47093728
54Abnormality of pyrimidine metabolism (HP:0004353)3.33413667
55Ketoacidosis (HP:0001993)3.30687233
56Systemic lupus erythematosus (HP:0002725)3.19047613
57Autoimmune thrombocytopenia (HP:0001973)3.16038189
58Conjugated hyperbilirubinemia (HP:0002908)3.14008885
59Abnormality of nucleobase metabolism (HP:0010932)3.09869235
60Nuclear cataract (HP:0100018)3.07304286
61Hyperbilirubinemia (HP:0002904)3.02229407
62Myocardial infarction (HP:0001658)2.98250351
63Abnormality of purine metabolism (HP:0004352)2.98097018
64Abnormality of serum amino acid levels (HP:0003112)2.97526729
65Purpura (HP:0000979)2.96417608
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.92444702
67Dicarboxylic aciduria (HP:0003215)2.92444702
68Increased serum ferritin (HP:0003281)2.88902157
69Gout (HP:0001997)2.85868925
70Delayed CNS myelination (HP:0002188)2.81661789
71Metabolic acidosis (HP:0001942)2.79694903
72Recurrent gram-negative bacterial infections (HP:0005420)2.79532869
73Mediastinal lymphadenopathy (HP:0100721)2.78462866
74Steatorrhea (HP:0002570)2.78115217
75Metaphyseal irregularity (HP:0003025)2.76730258
76Glomerulonephritis (HP:0000099)2.74686631
77Hepatocellular carcinoma (HP:0001402)2.73848108
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.72737799
79Skin nodule (HP:0200036)2.72108907
80Lethargy (HP:0001254)2.67741306
81Abnormality of the vasculature of the conjunctiva (HP:0008054)2.64809826
82Cerebral inclusion bodies (HP:0100314)2.62225012
83Upper motor neuron abnormality (HP:0002127)2.60433236
84Apathy (HP:0000741)2.60040769
85Spontaneous abortion (HP:0005268)2.59522012
86Diminished motivation (HP:0000745)2.57421676
87Retinal atrophy (HP:0001105)2.56323909
88Hepatosplenomegaly (HP:0001433)2.54901658
89Generalized aminoaciduria (HP:0002909)2.53709931
90Progressive neurologic deterioration (HP:0002344)2.48361979
91Hypoglycemic seizures (HP:0002173)2.44644675
92Amyloidosis (HP:0011034)2.43104412
93Cerebral edema (HP:0002181)2.42868015
94Hypochromic microcytic anemia (HP:0004840)2.42395040
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41507563
96Vascular calcification (HP:0004934)2.38292485
97Neuronal loss in central nervous system (HP:0002529)2.35369335
98Late onset (HP:0003584)2.33991374
99Abnormality of the periventricular white matter (HP:0002518)2.33901237
100Pancreatitis (HP:0001733)2.32739518
101Irritability (HP:0000737)2.31533370
102Agnosia (HP:0010524)2.31348378
103Prolonged neonatal jaundice (HP:0006579)2.31294028
104Orchitis (HP:0100796)2.29556046
105Abnormal gallbladder morphology (HP:0012437)2.29240950
106Spastic diplegia (HP:0001264)2.27803818
107Cholelithiasis (HP:0001081)2.25701146
108Chronic obstructive pulmonary disease (HP:0006510)2.23728858
109Obstructive lung disease (HP:0006536)2.23728858
110Vomiting (HP:0002013)2.23008004
111Esophageal varix (HP:0002040)2.21969018
112Myositis (HP:0100614)2.21173559
113Mitral stenosis (HP:0001718)2.21048083
114Dementia (HP:0000726)2.20019130
115Pathologic fracture (HP:0002756)2.18427613
116Hydroxyprolinuria (HP:0003080)2.17171822
117Abnormality of proline metabolism (HP:0010907)2.17171822
118Hemorrhage of the eye (HP:0011885)2.16979539
119Malnutrition (HP:0004395)2.16910656
120Acanthocytosis (HP:0001927)2.14548829
121Neonatal onset (HP:0003623)2.14030118
122Petechiae (HP:0000967)2.13687527
123Bone pain (HP:0002653)2.13408360
124Cardiovascular calcification (HP:0011915)2.13250585
125Asymmetric septal hypertrophy (HP:0001670)2.11779493
126Menorrhagia (HP:0000132)2.10742310
127Abnormality of iron homeostasis (HP:0011031)2.09904829
128Inappropriate behavior (HP:0000719)2.08350933
129Nausea (HP:0002018)2.06200755
130Cholecystitis (HP:0001082)2.06077259
131Abnormal gallbladder physiology (HP:0012438)2.06077259
132Abnormality of transition element cation homeostasis (HP:0011030)2.04876711
133Retrobulbar optic neuritis (HP:0100654)2.04691751
134Optic neuritis (HP:0100653)2.04691751
135Enlarged kidneys (HP:0000105)2.03581224
136Hyperinsulinemic hypoglycemia (HP:0000825)2.03147004
137Sensorimotor neuropathy (HP:0007141)2.03137342
138Peripheral demyelination (HP:0011096)2.03108891
139Hyperuricemia (HP:0002149)2.02451370
140Increased purine levels (HP:0004368)2.02451370
141Gingival bleeding (HP:0000225)2.01632309
142Nephritis (HP:0000123)1.99965554
143Hypertriglyceridemia (HP:0002155)1.99807418
144Opisthotonus (HP:0002179)1.99441904
145Abnormal cartilage morphology (HP:0002763)1.98985909
146Brushfield spots (HP:0001088)1.98031108
147Protuberant abdomen (HP:0001538)1.97663748
148Gingivitis (HP:0000230)1.97555593
149Proximal tubulopathy (HP:0000114)1.97175579
150Cardiomegaly (HP:0001640)1.96792763
151Vertebral compression fractures (HP:0002953)1.95418256
152Recurrent skin infections (HP:0001581)1.95003384
153Thrombophlebitis (HP:0004418)1.94097295
154Thoracic kyphosis (HP:0002942)1.94018711
155Hematochezia (HP:0002573)1.92054438
156Multiple enchondromatosis (HP:0005701)1.90137867
157Mesangial abnormality (HP:0001966)1.89224511
158Pulmonary infiltrates (HP:0002113)1.89037605
159Alkalosis (HP:0001948)1.87307784
160Abnormality of the gallbladder (HP:0005264)1.86831955
161Thin bony cortex (HP:0002753)1.86553433
162Glycosuria (HP:0003076)1.86211709
163Abnormality of urine glucose concentration (HP:0011016)1.86211709
164Personality changes (HP:0000751)1.86030389
165Hyperglycemia (HP:0003074)1.85553179
166Elevated hepatic transaminases (HP:0002910)1.84476043
167Neoplasm of head and neck (HP:0012288)1.82931519
168Esophageal neoplasm (HP:0100751)1.82931519
169Conjunctival telangiectasia (HP:0000524)1.79591835
170Stomatitis (HP:0010280)1.78474490
171J-shaped sella turcica (HP:0002680)1.77605459
172Hypophosphatemia (HP:0002148)1.76559709
173Interstitial pulmonary disease (HP:0006530)1.71391826
174Hemoptysis (HP:0002105)1.70295518
175Polyneuropathy (HP:0001271)1.70184367
176Basal ganglia calcification (HP:0002135)1.68990261
177Premature loss of primary teeth (HP:0006323)1.66844617
178Bone cyst (HP:0012062)1.63437935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.74768883
2NME24.81048819
3ERN14.54333032
4FGFR43.95375863
5SIK13.89289600
6GRK73.08624063
7DDR23.03059905
8BLK2.80834320
9INSRR2.76674325
10TRIB32.73576324
11MUSK2.54478500
12ACVR1B2.46904126
13MATK2.46596363
14TAOK32.32507762
15PKN22.18248889
16FGR2.13036481
17RIPK42.10585328
18MST1R2.00503753
19ERBB41.97599376
20TYK21.81844282
21PTK61.77054012
22CAMK1D1.71718324
23FLT31.71695271
24TAOK11.68075829
25PIM21.64740296
26IRAK31.59703518
27IRAK41.57459979
28MAPK111.57216206
29RIPK11.54344392
30CDC42BPA1.52818803
31MAP2K41.51409375
32PIK3CG1.46868534
33ADRBK21.42338435
34NEK91.42180920
35ABL21.41278669
36TBK11.40418610
37FRK1.38020920
38PRPF4B1.35914646
39MAP2K31.31122365
40TESK11.29461288
41TIE11.28402951
42JAK21.28092023
43JAK11.26657392
44DAPK21.25797760
45PRKAA21.22520226
46KDR1.20602769
47MAP3K141.16401219
48TESK21.15809875
49LATS11.13962193
50MAP3K31.13234333
51PDK31.10916574
52PDK41.10916574
53CAMKK21.06459372
54TGFBR21.06292284
55IKBKB1.05482525
56PINK10.99991484
57LYN0.93959131
58MAP3K70.93521911
59MOS0.92982661
60CAMK1G0.89645968
61CSK0.88589581
62MAPK150.84291864
63MAPK40.83396512
64PAK40.83161911
65GRK60.82872632
66EPHB20.82138491
67SYK0.80077681
68MAP3K110.79958352
69MET0.78304882
70FGFR20.77222752
71CHUK0.77186094
72EPHB10.77088124
73IKBKE0.73227214
74GSK3A0.72783273
75FGFR30.72000023
76FES0.71915210
77PRKAA10.70596369
78PRKACG0.70580406
79MAP3K100.70147814
80TXK0.69306008
81PDK20.68974502
82PDPK10.66669570
83PRKCZ0.66649038
84IRAK20.65549833
85CSF1R0.63822139
86MAPK120.63151814
87TYRO30.62481926
88CDK60.62198180
89LCK0.61368285
90RPS6KC10.61367727
91RPS6KL10.61367727
92STK38L0.59399092
93ERBB20.58892000
94KIT0.57557133
95MAP4K10.57146146
96EPHA30.57012367
97MARK30.55608430
98LIMK10.55402237
99RPS6KA20.54764202
100TGFBR10.52542552
101SGK30.52141043
102MAP3K130.52109151
103IGF1R0.50450410
104DYRK1B0.49162071
105RPS6KA60.48577644
106HCK0.48267171
107MAP2K10.47195971
108PDK10.46788790
109CAMK2G0.46775507
110BMPR20.46415509
111TAOK20.43326933
112JAK30.43076197
113ARAF0.42297780
114MAP2K20.41574141
115BTK0.39915010
116CSNK1G10.39795532
117PRKCH0.38319244
118DAPK30.37985369
119PTK20.37750083
120CAMK40.37590907
121MAP3K50.37311116
122ZAP700.36113336
123MYLK0.35835687
124CDK40.35740109
125PDGFRA0.35066000
126MAP2K60.34634036
127MTOR0.34241518
128MAPK70.33656910
129MAP3K10.33221962
130TTN0.31447781
131PRKCQ0.31187100
132PBK0.30980235
133BMX0.30587020
134ICK0.30266972
135PRKG20.29802461
136GRK10.29701095
137SGK20.29686269
138PRKCD0.28605690
139PIK3CA0.28217455
140MAPKAPK20.28057417
141MAP3K60.27568297
142RET0.27501500
143TNK20.26847262
144EGFR0.26538204
145IRAK10.26351337
146MAPKAPK30.25832067
147ABL10.25512381
148INSR0.24362134
149PIM10.23503047
150PDGFRB0.22864269

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.24908713
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.20510187
3Nitrogen metabolism_Homo sapiens_hsa009103.48986337
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15974163
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.05117345
6Arginine biosynthesis_Homo sapiens_hsa002202.95567656
7Rheumatoid arthritis_Homo sapiens_hsa053232.77137149
8Fatty acid degradation_Homo sapiens_hsa000712.71355677
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70960432
10Complement and coagulation cascades_Homo sapiens_hsa046102.65896458
11Tryptophan metabolism_Homo sapiens_hsa003802.63478178
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63056010
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50813243
14Asthma_Homo sapiens_hsa053102.46100769
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43199541
16Propanoate metabolism_Homo sapiens_hsa006402.26467096
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24604464
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23730304
19Allograft rejection_Homo sapiens_hsa053302.20299281
20Osteoclast differentiation_Homo sapiens_hsa043802.17036819
21Peroxisome_Homo sapiens_hsa041462.15121094
22Leishmaniasis_Homo sapiens_hsa051402.14496809
23Butanoate metabolism_Homo sapiens_hsa006502.13819559
24* PPAR signaling pathway_Homo sapiens_hsa033202.11377224
25Fatty acid metabolism_Homo sapiens_hsa012122.02979229
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98632595
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95360747
28Staphylococcus aureus infection_Homo sapiens_hsa051501.93280589
29Tuberculosis_Homo sapiens_hsa051521.85843231
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.85443797
31beta-Alanine metabolism_Homo sapiens_hsa004101.82430913
32Autoimmune thyroid disease_Homo sapiens_hsa053201.80496761
33Graft-versus-host disease_Homo sapiens_hsa053321.79967638
34Histidine metabolism_Homo sapiens_hsa003401.78378264
35Caffeine metabolism_Homo sapiens_hsa002321.78367364
36Chemical carcinogenesis_Homo sapiens_hsa052041.78153304
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77247417
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.72039423
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71009541
40Phagosome_Homo sapiens_hsa041451.69831578
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.63992091
42Antigen processing and presentation_Homo sapiens_hsa046121.59142321
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56552713
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55828196
45Malaria_Homo sapiens_hsa051441.55586801
46Selenocompound metabolism_Homo sapiens_hsa004501.53421093
47Retinol metabolism_Homo sapiens_hsa008301.52614884
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.52408105
49Collecting duct acid secretion_Homo sapiens_hsa049661.50536258
50Phenylalanine metabolism_Homo sapiens_hsa003601.49955319
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47014213
52Pyruvate metabolism_Homo sapiens_hsa006201.45831853
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45788698
54Bile secretion_Homo sapiens_hsa049761.41116349
55Type I diabetes mellitus_Homo sapiens_hsa049401.39610152
56Sulfur metabolism_Homo sapiens_hsa009201.38539108
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38348784
58TNF signaling pathway_Homo sapiens_hsa046681.38253062
59Tyrosine metabolism_Homo sapiens_hsa003501.34022094
60Starch and sucrose metabolism_Homo sapiens_hsa005001.33177853
61Fatty acid elongation_Homo sapiens_hsa000621.32566295
62Fat digestion and absorption_Homo sapiens_hsa049751.31176376
63Folate biosynthesis_Homo sapiens_hsa007901.28597222
64Carbon metabolism_Homo sapiens_hsa012001.26701973
65Legionellosis_Homo sapiens_hsa051341.26485731
66ABC transporters_Homo sapiens_hsa020101.25711435
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.19198054
68Toxoplasmosis_Homo sapiens_hsa051451.19075591
69Salmonella infection_Homo sapiens_hsa051321.18968547
70Biosynthesis of amino acids_Homo sapiens_hsa012301.17827309
71NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16544570
72Maturity onset diabetes of the young_Homo sapiens_hsa049501.08818357
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06530427
74Vitamin B6 metabolism_Homo sapiens_hsa007501.04885876
75Steroid biosynthesis_Homo sapiens_hsa001001.04495295
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04304125
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02725932
78Hematopoietic cell lineage_Homo sapiens_hsa046401.02174299
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99922396
80Sphingolipid metabolism_Homo sapiens_hsa006000.99891440
81Influenza A_Homo sapiens_hsa051640.96217444
82Vitamin digestion and absorption_Homo sapiens_hsa049770.95986576
83Viral myocarditis_Homo sapiens_hsa054160.95397359
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93796514
85Sulfur relay system_Homo sapiens_hsa041220.93675888
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93607371
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.93087535
88Arginine and proline metabolism_Homo sapiens_hsa003300.92182159
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91485399
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90158588
91Glycerolipid metabolism_Homo sapiens_hsa005610.90068623
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89733316
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87447701
94Vibrio cholerae infection_Homo sapiens_hsa051100.84333672
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82945286
96Fatty acid biosynthesis_Homo sapiens_hsa000610.77448980
97Lysine degradation_Homo sapiens_hsa003100.77259866
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74441676
99Chemokine signaling pathway_Homo sapiens_hsa040620.72978277
100Herpes simplex infection_Homo sapiens_hsa051680.68093442
101Pentose phosphate pathway_Homo sapiens_hsa000300.68074448
102Glutathione metabolism_Homo sapiens_hsa004800.66674032
103B cell receptor signaling pathway_Homo sapiens_hsa046620.65181912
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61788686
105Bladder cancer_Homo sapiens_hsa052190.61112549
106Shigellosis_Homo sapiens_hsa051310.55623683
107One carbon pool by folate_Homo sapiens_hsa006700.54535695
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53709270
109Apoptosis_Homo sapiens_hsa042100.48975130
110Metabolic pathways_Homo sapiens_hsa011000.47033340
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.43698467
112Prion diseases_Homo sapiens_hsa050200.37763744
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.37292065
114Galactose metabolism_Homo sapiens_hsa000520.36589452
115Acute myeloid leukemia_Homo sapiens_hsa052210.36335348
116Fructose and mannose metabolism_Homo sapiens_hsa000510.35217152
117Measles_Homo sapiens_hsa051620.34747627
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34672651
119* Insulin resistance_Homo sapiens_hsa049310.33384264
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28589942
121Hepatitis B_Homo sapiens_hsa051610.28148286
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.26508026
123Ether lipid metabolism_Homo sapiens_hsa005650.25591309
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25044046
125Linoleic acid metabolism_Homo sapiens_hsa005910.18352494
126AMPK signaling pathway_Homo sapiens_hsa041520.14214439
127Glucagon signaling pathway_Homo sapiens_hsa049220.13286785
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.06505928
129* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05615101
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03782891
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01154715
132Protein digestion and absorption_Homo sapiens_hsa04974-0.1758247
133Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1704109
134Amoebiasis_Homo sapiens_hsa05146-0.1674551
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1665009
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1639020
137* Hepatitis C_Homo sapiens_hsa05160-0.1551145
138Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1361367
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1334682
140Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1322004
141African trypanosomiasis_Homo sapiens_hsa05143-0.1294459
142Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1285622
143Mineral absorption_Homo sapiens_hsa04978-0.1204134
144Pertussis_Homo sapiens_hsa05133-0.1104145
145Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0889569
146Renin-angiotensin system_Homo sapiens_hsa04614-0.0782197
147Regulation of autophagy_Homo sapiens_hsa04140-0.0525810
148Lysosome_Homo sapiens_hsa04142-0.0439908
149Insulin signaling pathway_Homo sapiens_hsa04910-0.0159892

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