NR1I2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* exogenous drug catabolic process (GO:0042738)7.53642895
2L-phenylalanine catabolic process (GO:0006559)7.38384161
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.38384161
4* drug catabolic process (GO:0042737)7.35021924
5omega-hydroxylase P450 pathway (GO:0097267)7.13084944
6L-phenylalanine metabolic process (GO:0006558)7.09035184
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.09035184
8aromatic amino acid family catabolic process (GO:0009074)6.64308317
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.57612775
10* drug metabolic process (GO:0017144)6.08086272
11tryptophan catabolic process (GO:0006569)6.00239738
12indole-containing compound catabolic process (GO:0042436)6.00239738
13indolalkylamine catabolic process (GO:0046218)6.00239738
14kynurenine metabolic process (GO:0070189)5.87995056
15bile acid biosynthetic process (GO:0006699)5.74505617
16urea cycle (GO:0000050)5.70774532
17urea metabolic process (GO:0019627)5.70774532
18tryptophan metabolic process (GO:0006568)5.64594375
19high-density lipoprotein particle remodeling (GO:0034375)5.64296498
20glyoxylate metabolic process (GO:0046487)5.53819132
21alpha-linolenic acid metabolic process (GO:0036109)5.50070996
22negative regulation of fibrinolysis (GO:0051918)5.39555657
23sulfur amino acid catabolic process (GO:0000098)5.27048165
24nitrogen cycle metabolic process (GO:0071941)5.23836383
25fat-soluble vitamin biosynthetic process (GO:0042362)5.19671126
26cysteine metabolic process (GO:0006534)5.19420908
27regulation of fibrinolysis (GO:0051917)5.18906771
28protein carboxylation (GO:0018214)5.17313234
29peptidyl-glutamic acid carboxylation (GO:0017187)5.17313234
30regulation of cholesterol esterification (GO:0010872)5.12006601
31regulation of triglyceride catabolic process (GO:0010896)5.09718157
32regulation of protein activation cascade (GO:2000257)5.08184910
33complement activation, alternative pathway (GO:0006957)5.07547720
34bile acid metabolic process (GO:0008206)5.01923813
35ethanol metabolic process (GO:0006067)4.98630404
36reverse cholesterol transport (GO:0043691)4.96212120
37serine family amino acid catabolic process (GO:0009071)4.95997417
38protein-lipid complex remodeling (GO:0034368)4.86349146
39macromolecular complex remodeling (GO:0034367)4.86349146
40plasma lipoprotein particle remodeling (GO:0034369)4.86349146
41phospholipid efflux (GO:0033700)4.83639566
42aromatic amino acid family metabolic process (GO:0009072)4.83359183
43regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.82074809
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81030041
45homocysteine metabolic process (GO:0050667)4.78981599
46negative regulation of sterol transport (GO:0032372)4.78171979
47negative regulation of cholesterol transport (GO:0032375)4.78171979
48regulation of complement activation (GO:0030449)4.72376138
49oxidative demethylation (GO:0070989)4.71880928
50hormone catabolic process (GO:0042447)4.68646154
51tyrosine metabolic process (GO:0006570)4.67082452
52intestinal absorption (GO:0050892)4.66925570
53acylglycerol homeostasis (GO:0055090)4.66361424
54triglyceride homeostasis (GO:0070328)4.66361424
55phenylpropanoid metabolic process (GO:0009698)4.63743237
56angiotensin maturation (GO:0002003)4.58810372
57alkaloid metabolic process (GO:0009820)4.57864539
58amino-acid betaine metabolic process (GO:0006577)4.57276463
59bile acid and bile salt transport (GO:0015721)4.52053191
60alpha-amino acid catabolic process (GO:1901606)4.51290815
61lysine catabolic process (GO:0006554)4.50403690
62lysine metabolic process (GO:0006553)4.50403690
63cholesterol efflux (GO:0033344)4.40731905
64cellular ketone body metabolic process (GO:0046950)4.39882684
65plasma lipoprotein particle clearance (GO:0034381)4.38417136
66cellular glucuronidation (GO:0052695)4.33649590
67indolalkylamine metabolic process (GO:0006586)4.24455583
68coenzyme catabolic process (GO:0009109)4.23669015
69negative regulation of hemostasis (GO:1900047)4.23506059
70negative regulation of blood coagulation (GO:0030195)4.23506059
71plasma lipoprotein particle assembly (GO:0034377)4.21982223
72glycine metabolic process (GO:0006544)4.20850416
73cellular amino acid catabolic process (GO:0009063)4.16052399
74amine catabolic process (GO:0009310)4.15735900
75cellular biogenic amine catabolic process (GO:0042402)4.15735900
76glutamate metabolic process (GO:0006536)4.15626012
77imidazole-containing compound metabolic process (GO:0052803)4.15420398
78benzene-containing compound metabolic process (GO:0042537)4.07630972
79positive regulation of lipoprotein lipase activity (GO:0051006)4.06289771
80positive regulation of triglyceride lipase activity (GO:0061365)4.06289771
81intestinal cholesterol absorption (GO:0030299)4.04823633
82regulation of plasminogen activation (GO:0010755)4.03451092
83serine family amino acid metabolic process (GO:0009069)4.02813582
84arginine metabolic process (GO:0006525)4.00128867
85regulation of bile acid biosynthetic process (GO:0070857)3.99923721
86cellular modified amino acid catabolic process (GO:0042219)3.97313709
87flavonoid metabolic process (GO:0009812)3.94703084
88low-density lipoprotein particle remodeling (GO:0034374)3.94228020
89ethanol oxidation (GO:0006069)3.93595159
90very-low-density lipoprotein particle assembly (GO:0034379)3.93424191
91acute-phase response (GO:0006953)3.92655191
92NADH metabolic process (GO:0006734)3.92444651
93cholesterol homeostasis (GO:0042632)3.91033398
94dicarboxylic acid biosynthetic process (GO:0043650)3.88060659
95positive regulation of lipid catabolic process (GO:0050996)3.87936534
96negative regulation of coagulation (GO:0050819)3.87789187
97fibrinolysis (GO:0042730)3.86039609
98serine family amino acid biosynthetic process (GO:0009070)3.85738289
99uronic acid metabolic process (GO:0006063)3.84933597
100glucuronate metabolic process (GO:0019585)3.84933597
101sterol homeostasis (GO:0055092)3.84880036
102aldehyde catabolic process (GO:0046185)3.81809616
103ketone body metabolic process (GO:1902224)3.80573446
104protein-lipid complex assembly (GO:0065005)3.79511274
105negative regulation of lipase activity (GO:0060192)3.79503182
106phospholipid homeostasis (GO:0055091)3.79046136
107regulation of cholesterol homeostasis (GO:2000188)3.78823165
108fructose metabolic process (GO:0006000)3.76911093
109negative regulation of wound healing (GO:0061045)3.73547682
110plasma lipoprotein particle organization (GO:0071827)3.73336819
111positive regulation of fatty acid biosynthetic process (GO:0045723)3.71676370
112blood coagulation, intrinsic pathway (GO:0007597)3.69432592
113cofactor catabolic process (GO:0051187)3.67999234
114organic acid catabolic process (GO:0016054)3.67083163
115carboxylic acid catabolic process (GO:0046395)3.67083163
116lipoprotein metabolic process (GO:0042157)3.66596234
117regulation of humoral immune response (GO:0002920)3.63921266
118short-chain fatty acid metabolic process (GO:0046459)3.63459610
119complement activation, classical pathway (GO:0006958)3.58032726
120protein activation cascade (GO:0072376)3.57069376
121epoxygenase P450 pathway (GO:0019373)3.56069649
122protein-lipid complex subunit organization (GO:0071825)3.56012382
123acetyl-CoA metabolic process (GO:0006084)3.55398091
124complement activation (GO:0006956)3.54930061
125drug transmembrane transport (GO:0006855)3.52019926
126S-adenosylmethionine metabolic process (GO:0046500)3.47820103
127heme transport (GO:0015886)3.43709099
128diacylglycerol metabolic process (GO:0046339)3.43343045
129renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.41022437
130renal system process involved in regulation of blood volume (GO:0001977)3.40775257
131lipoprotein transport (GO:0042953)3.39557268
132oxaloacetate metabolic process (GO:0006107)3.35065988
133negative regulation of protein activation cascade (GO:2000258)3.33830519
134* xenobiotic metabolic process (GO:0006805)3.32514467
135proline metabolic process (GO:0006560)3.31799657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.27624296
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13961771
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.86632014
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.45199072
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.20569779
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.01710104
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84205946
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97697709
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.89080858
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.19195406
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02827542
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7722086
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93198112
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74693715
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69018943
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.62765656
17CLOCK_20551151_ChIP-Seq_293T_Human1.55890229
18HTT_18923047_ChIP-ChIP_STHdh_Human1.52639826
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.47601338
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.46027218
21GATA1_22025678_ChIP-Seq_K562_Human1.44650018
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36888254
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31476869
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.27257627
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25172263
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23880649
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22496058
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17128268
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13697246
30* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13084782
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09192191
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06966640
33GATA4_25053715_ChIP-Seq_YYC3_Human1.05512502
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01295478
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.01094745
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.00011775
37CDX2_20551321_ChIP-Seq_CACO-2_Human0.90609398
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89821525
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89048155
40CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87536163
41SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85702689
42SA1_27219007_Chip-Seq_Bcells_Human0.84095779
43BCL6_27268052_Chip-Seq_Bcells_Human0.83943668
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82893907
45BCOR_27268052_Chip-Seq_Bcells_Human0.82783277
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82679882
47RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82669312
48KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82144510
49IRF8_22096565_ChIP-ChIP_GC-B_Human0.81682284
50JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.79902024
51TET1_21451524_ChIP-Seq_MESCs_Mouse0.79284400
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78663864
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78532095
54SOX2_21211035_ChIP-Seq_LN229_Human0.77774162
55DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76779527
56SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76221060
57ZNF263_19887448_ChIP-Seq_K562_Human0.75632054
58ESR2_21235772_ChIP-Seq_MCF-7_Human0.75051727
59* RARA_24833708_ChIP-Seq_LIVER_Mouse0.74966052
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74445955
61* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74219657
62CTCF_27219007_Chip-Seq_Bcells_Human0.74191179
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73742761
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73425316
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73294234
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.72977408
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72518822
68SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71660517
69E2F1_20622854_ChIP-Seq_HELA_Human0.71630679
70* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71557554
71P63_26484246_Chip-Seq_KERATINOCYTES_Human0.71074076
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69591561
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67606875
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.66975314
75RAC3_21632823_ChIP-Seq_H3396_Human0.65784633
76NANOG_20526341_ChIP-Seq_ESCs_Human0.64988016
77GATA6_25053715_ChIP-Seq_YYC3_Human0.64535017
78PHF8_20622854_ChIP-Seq_HELA_Human0.64303266
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.63612718
80SMC4_20622854_ChIP-Seq_HELA_Human0.63374724
81GATA2_22383799_ChIP-Seq_G1ME_Mouse0.62909114
82RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62740157
83RARB_24833708_ChIP-Seq_LIVER_Mouse0.62642165
84P300_27268052_Chip-Seq_Bcells_Human0.61372785
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61009123
86NRF2_20460467_ChIP-Seq_MEFs_Mouse0.60848293
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.60848293
88DROSHA_22980978_ChIP-Seq_HELA_Human0.60571381
89CTCF_20526341_ChIP-Seq_ESCs_Human0.60275484
90CEBPB_22108803_ChIP-Seq_LS180_Human0.60263453
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58734035
92FOXA1_25552417_ChIP-Seq_VCAP_Human0.57078563
93EGR1_19032775_ChIP-ChIP_M12_Human0.56838580
94LXR_22292898_ChIP-Seq_THP-1_Human0.56798875
95PPAR_26484153_Chip-Seq_NCI-H1993_Human0.54989865
96* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53941089
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53893251
98SOX2_20726797_ChIP-Seq_SW620_Human0.53217031
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53182483
100AR_20517297_ChIP-Seq_VCAP_Human0.53159021
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.51589686
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.51438668
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.51320611
104* MYC_19915707_ChIP-ChIP_AK7_Human0.50854360
105STAT1_17558387_ChIP-Seq_HELA_Human0.50569907
106ESET_19884257_ChIP-Seq_ESCs_Mouse0.49644643
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49416634
108P53_21459846_ChIP-Seq_SAOS-2_Human0.49184404
109GATA2_19941826_ChIP-Seq_K562_Human0.48610545
110CBP_21632823_ChIP-Seq_H3396_Human0.47236532
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.46168468
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.44908081
113GATA1_19941826_ChIP-Seq_K562_Human0.44295923
114TAF2_19829295_ChIP-Seq_ESCs_Human0.43970176
115BCAT_22108803_ChIP-Seq_LS180_Human0.43790351
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43567543
117* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43074720
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43015529
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.42970200
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.40775804
121CDX2_22108803_ChIP-Seq_LS180_Human0.40330048
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40272600
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39035437
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.38552575
125ERG_20517297_ChIP-Seq_VCAP_Human0.36830160
126MYC_27129775_Chip-Seq_CORNEA_Mouse0.36794961
127RACK7_27058665_Chip-Seq_MCF-7_Human0.36727921
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.36384721
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36280323
130CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36177074
131NCOR_22424771_ChIP-Seq_293T_Human0.35630327
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.34905073
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34856777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.21734132
2MP0005360_urolithiasis7.85785666
3MP0005085_abnormal_gallbladder_physiolo6.42650930
4MP0005365_abnormal_bile_salt6.04374945
5MP0008875_abnormal_xenobiotic_pharmacok5.27332185
6MP0003806_abnormal_nucleotide_metabolis4.07636633
7MP0003252_abnormal_bile_duct3.97481930
8MP0010329_abnormal_lipoprotein_level3.61220283
9MP0009840_abnormal_foam_cell3.42378356
10MP0001666_abnormal_nutrient_absorption2.95785248
11MP0005083_abnormal_biliary_tract2.93924130
12MP0005332_abnormal_amino_acid2.71762226
13MP0003195_calcinosis2.59290819
14MP0003191_abnormal_cellular_cholesterol2.32831936
15MP0004019_abnormal_vitamin_homeostasis2.19646156
16* MP0000609_abnormal_liver_physiology2.10705615
17MP0002118_abnormal_lipid_homeostasis2.08352217
18MP0003868_abnormal_feces_composition1.93269075
19MP0002138_abnormal_hepatobiliary_system1.88569523
20MP0003183_abnormal_peptide_metabolism1.83090536
21* MP0005319_abnormal_enzyme/_coenzyme1.72650739
22MP0001764_abnormal_homeostasis1.62966377
23MP0009697_abnormal_copulation1.61446589
24MP0005451_abnormal_body_composition1.53231540
25MP0005584_abnormal_enzyme/coenzyme_acti1.51603821
26MP0010155_abnormal_intestine_physiology1.38549952
27MP0009643_abnormal_urine_homeostasis1.27353141
28MP0003011_delayed_dark_adaptation1.26894493
29MP0003656_abnormal_erythrocyte_physiolo1.21390471
30MP0003705_abnormal_hypodermis_morpholog1.19964367
31MP0004147_increased_porphyrin_level1.17537961
32MP0009379_abnormal_foot_pigmentation1.17430853
33MP0003186_abnormal_redox_activity1.15614918
34MP0000598_abnormal_liver_morphology1.13770509
35MP0005409_darkened_coat_color1.07278251
36MP0005647_abnormal_sex_gland1.03796414
37MP0002254_reproductive_system_inflammat1.03584312
38MP0000604_amyloidosis1.03204193
39MP0009764_decreased_sensitivity_to1.03023552
40MP0003879_abnormal_hair_cell0.98551202
41MP0003866_abnormal_defecation0.98069453
42MP0009763_increased_sensitivity_to0.97521585
43MP0005636_abnormal_mineral_homeostasis0.95613542
44MP0005084_abnormal_gallbladder_morpholo0.87771462
45MP0009642_abnormal_blood_homeostasis0.87132508
46MP0002132_abnormal_respiratory_system0.86792817
47MP0008469_abnormal_protein_level0.86125614
48MP0005408_hypopigmentation0.81398367
49MP0005670_abnormal_white_adipose0.81311001
50MP0010368_abnormal_lymphatic_system0.81098677
51MP0009765_abnormal_xenobiotic_induced0.79343729
52MP0005376_homeostasis/metabolism_phenot0.78961052
53MP0002876_abnormal_thyroid_physiology0.77389778
54MP0006036_abnormal_mitochondrial_physio0.76794303
55MP0002078_abnormal_glucose_homeostasis0.75724846
56MP0000477_abnormal_intestine_morphology0.75010847
57MP0001664_abnormal_digestion0.73985807
58MP0009785_altered_susceptibility_to0.71791646
59MP0002971_abnormal_brown_adipose0.71584224
60MP0001663_abnormal_digestive_system0.69476995
61MP0009053_abnormal_anal_canal0.68157016
62MP0002822_catalepsy0.67576106
63MP0005266_abnormal_metabolism0.67397116
64MP0005334_abnormal_fat_pad0.67131943
65MP0005220_abnormal_exocrine_pancreas0.66765394
66MP0005058_abnormal_lysosome_morphology0.65558167
67MP0001765_abnormal_ion_homeostasis0.65486217
68MP0005448_abnormal_energy_balance0.62359748
69MP0005535_abnormal_body_temperature0.61425797
70MP0000678_abnormal_parathyroid_gland0.61171861
71MP0004130_abnormal_muscle_cell0.61125393
72MP0001756_abnormal_urination0.60076110
73MP0003690_abnormal_glial_cell0.58826956
74MP0001661_extended_life_span0.58296248
75MP0003329_amyloid_beta_deposits0.58069760
76MP0010234_abnormal_vibrissa_follicle0.57987746
77MP0000566_synostosis0.57985193
78MP0010352_gastrointestinal_tract_polyps0.54183226
79MP0005381_digestive/alimentary_phenotyp0.53756030
80MP0000639_abnormal_adrenal_gland0.53607807
81MP0000490_abnormal_crypts_of0.53488731
82MP0005464_abnormal_platelet_physiology0.53336377
83MP0002249_abnormal_larynx_morphology0.52903066
84MP0003718_maternal_effect0.52119077
85MP0006035_abnormal_mitochondrial_morpho0.51285604
86MP0004264_abnormal_extraembryonic_tissu0.50001929
87MP0002136_abnormal_kidney_physiology0.49924545
88MP0003638_abnormal_response/metabolism_0.47455527
89MP0005395_other_phenotype0.46483794
90MP0005023_abnormal_wound_healing0.46261103
91MP0004782_abnormal_surfactant_physiolog0.43592868
92MP0005166_decreased_susceptibility_to0.41883676
93MP0005666_abnormal_adipose_tissue0.40977331
94MP0003953_abnormal_hormone_level0.40952907
95MP0001873_stomach_inflammation0.40559136
96MP0002796_impaired_skin_barrier0.40488543
97MP0005025_abnormal_response_to0.39759373
98MP0003724_increased_susceptibility_to0.39415966
99MP0004858_abnormal_nervous_system0.39310950
100* MP0008873_increased_physiological_sensi0.39287583
101MP0002928_abnormal_bile_duct0.39120007
102MP0003436_decreased_susceptibility_to0.38879943
103MP0005248_abnormal_Harderian_gland0.38179475
104MP0009384_cardiac_valve_regurgitation0.36972958
105MP0000579_abnormal_nail_morphology0.36414309
106MP0003075_altered_response_to0.36102976
107MP0009115_abnormal_fat_cell0.35608816
108MP0002098_abnormal_vibrissa_morphology0.34580928
109* MP0008874_decreased_physiological_sensi0.33352284
110MP0000462_abnormal_digestive_system0.32762865
111MP0000230_abnormal_systemic_arterial0.32720579
112MP0000249_abnormal_blood_vessel0.32174905
113MP0005167_abnormal_blood-brain_barrier0.31827763
114MP0000467_abnormal_esophagus_morphology0.31749557
115MP0002168_other_aberrant_phenotype0.31481317
116MP0002837_dystrophic_cardiac_calcinosis0.30471210
117MP0009672_abnormal_birth_weight0.29754439
118MP0001881_abnormal_mammary_gland0.29590826
119MP0001845_abnormal_inflammatory_respons0.29555713
120MP0006082_CNS_inflammation0.29335193
121MP0001243_abnormal_dermal_layer0.29236554
122MP0004883_abnormal_blood_vessel0.28158715
123MP0002970_abnormal_white_adipose0.28136733
124MP0003453_abnormal_keratinocyte_physiol0.27450979
125MP0002060_abnormal_skin_morphology0.27076617
126MP0000538_abnormal_urinary_bladder0.26941672
127MP0002166_altered_tumor_susceptibility0.26890184
128MP0002089_abnormal_postnatal_growth/wei0.26747179
129MP0003300_gastrointestinal_ulcer0.26656414
130MP0004043_abnormal_pH_regulation0.26625899

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.26033513
2Deep venous thrombosis (HP:0002625)7.17636982
3Intrahepatic cholestasis (HP:0001406)7.15825032
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.72694650
5Hypobetalipoproteinemia (HP:0003563)6.70946677
6Prolonged partial thromboplastin time (HP:0003645)6.34217387
7Xanthomatosis (HP:0000991)6.31000806
8Hyperlipoproteinemia (HP:0010980)5.43401643
9Complement deficiency (HP:0004431)5.04061247
10Hypolipoproteinemia (HP:0010981)4.94933175
11Hyperammonemia (HP:0001987)4.60937530
12Joint hemorrhage (HP:0005261)4.57328131
13Epidermoid cyst (HP:0200040)4.53423826
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.50236513
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.48594711
16Abnormality of the common coagulation pathway (HP:0010990)4.31459751
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.28555988
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.24884491
19Hypoalphalipoproteinemia (HP:0003233)4.21943993
20Hyperglycinemia (HP:0002154)4.21494022
21Fat malabsorption (HP:0002630)4.21171269
22Abnormality of methionine metabolism (HP:0010901)4.20857428
23Ketosis (HP:0001946)4.18350610
24Hyperglycinuria (HP:0003108)3.96528806
25Conjugated hyperbilirubinemia (HP:0002908)3.95386127
26Abnormality of glycine metabolism (HP:0010895)3.88654892
27Abnormality of serine family amino acid metabolism (HP:0010894)3.88654892
28Hypoglycemic coma (HP:0001325)3.87672800
29Abnormality of pyrimidine metabolism (HP:0004353)3.85568034
30Hypercholesterolemia (HP:0003124)3.71597850
31Abnormality of complement system (HP:0005339)3.68680908
32Abnormality of the intrinsic pathway (HP:0010989)3.63182554
33Nephritis (HP:0000123)3.62189370
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37641786
35Hyperbilirubinemia (HP:0002904)3.37159971
36Abnormality of fatty-acid metabolism (HP:0004359)3.30599851
37Abnormality of nucleobase metabolism (HP:0010932)3.13458938
38Steatorrhea (HP:0002570)3.01643001
39Spontaneous abortion (HP:0005268)3.00148885
40Ketoacidosis (HP:0001993)2.98900621
41Abnormality of serum amino acid levels (HP:0003112)2.94269719
42Delayed CNS myelination (HP:0002188)2.94027155
43Acanthocytosis (HP:0001927)2.91910713
44Hepatocellular carcinoma (HP:0001402)2.90411972
45Myocardial infarction (HP:0001658)2.84098712
46Metabolic acidosis (HP:0001942)2.83688411
47Hypochromic microcytic anemia (HP:0004840)2.78070876
48Abnormality of purine metabolism (HP:0004352)2.77404389
49Skin nodule (HP:0200036)2.76546802
50Malnutrition (HP:0004395)2.62682059
51Lethargy (HP:0001254)2.61381806
52Systemic lupus erythematosus (HP:0002725)2.60789390
53Vascular calcification (HP:0004934)2.59942620
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56747506
55Dicarboxylic aciduria (HP:0003215)2.56747506
56Ileus (HP:0002595)2.56120915
57Hypoglycemic seizures (HP:0002173)2.52428871
58Widely patent fontanelles and sutures (HP:0004492)2.48827256
59Abnormal gallbladder morphology (HP:0012437)2.45374718
60Cholecystitis (HP:0001082)2.42732464
61Abnormal gallbladder physiology (HP:0012438)2.42732464
62Gout (HP:0001997)2.41902473
63Cholelithiasis (HP:0001081)2.40601258
64Spastic diplegia (HP:0001264)2.40386071
65Glomerulonephritis (HP:0000099)2.40172752
66Cerebral edema (HP:0002181)2.39181598
67Irritability (HP:0000737)2.35582443
68Hyperphosphaturia (HP:0003109)2.31810383
69Amyloidosis (HP:0011034)2.30488079
70Cardiovascular calcification (HP:0011915)2.29897695
71Abnormality of the vitamin B12 metabolism (HP:0004341)2.27071350
72Mitral stenosis (HP:0001718)2.25957665
73Poikilocytosis (HP:0004447)2.25606024
74Proximal tubulopathy (HP:0000114)2.22859169
75Neonatal onset (HP:0003623)2.22583259
76Purpura (HP:0000979)2.22528165
77Late onset (HP:0003584)2.21676053
78Esophageal varix (HP:0002040)2.20770603
79Nephrolithiasis (HP:0000787)2.19425698
80Gingival bleeding (HP:0000225)2.19124221
81Osteomalacia (HP:0002749)2.18704478
82Pancreatitis (HP:0001733)2.17922797
83Hypophosphatemia (HP:0002148)2.13833637
84Abnormality of proline metabolism (HP:0010907)2.13408098
85Hydroxyprolinuria (HP:0003080)2.13408098
86Brushfield spots (HP:0001088)2.13275658
87Confusion (HP:0001289)2.13023306
88Sensorimotor neuropathy (HP:0007141)2.12607266
89Abnormality of vitamin B metabolism (HP:0004340)2.11690130
90Recurrent gram-negative bacterial infections (HP:0005420)2.10901135
91Abnormal urine phosphate concentration (HP:0012599)2.10598154
92Menorrhagia (HP:0000132)2.08857781
93Vomiting (HP:0002013)2.08166939
94Abdominal distention (HP:0003270)2.07867654
95Enlarged kidneys (HP:0000105)2.05457044
96Facial shape deformation (HP:0011334)2.05119401
97Potter facies (HP:0002009)2.05119401
98Cerebral palsy (HP:0100021)2.05101706
99Hyperinsulinemic hypoglycemia (HP:0000825)2.04250723
100Pigmentary retinal degeneration (HP:0001146)2.03783384
101Generalized aminoaciduria (HP:0002909)2.01258078
102Thrombophlebitis (HP:0004418)2.01180808
103Opisthotonus (HP:0002179)2.00022556
104Abnormality of the gallbladder (HP:0005264)1.99448660
105Hemorrhage of the eye (HP:0011885)1.98550332
106Abnormal enzyme/coenzyme activity (HP:0012379)1.98516174
107Chronic diarrhea (HP:0002028)1.96049876
108Rickets (HP:0002748)1.95336282
109Megaloblastic anemia (HP:0001889)1.94717253
110Abnormality of alkaline phosphatase activity (HP:0004379)1.92760382
111Alkalosis (HP:0001948)1.92559206
112Elevated alkaline phosphatase (HP:0003155)1.92430917
113Nausea (HP:0002018)1.92239206
114Abnormal cartilage morphology (HP:0002763)1.91774324
115Increased purine levels (HP:0004368)1.91530889
116Hyperuricemia (HP:0002149)1.91530889
117Abnormality of transition element cation homeostasis (HP:0011030)1.90638271
118Abnormality of iron homeostasis (HP:0011031)1.90201464
119Pulmonary embolism (HP:0002204)1.86916266
120Abnormality of vitamin metabolism (HP:0100508)1.86687001
121Reticulocytosis (HP:0001923)1.84326862
122Focal segmental glomerulosclerosis (HP:0000097)1.83490321
123Glycosuria (HP:0003076)1.82483027
124Abnormality of urine glucose concentration (HP:0011016)1.82483027
125Hypophosphatemic rickets (HP:0004912)1.82366552
126Abnormal tarsal ossification (HP:0008369)1.82307676
127Hyperglycemia (HP:0003074)1.81632232
128Renal cortical cysts (HP:0000803)1.81560215
129Elevated hepatic transaminases (HP:0002910)1.79583794
130Hyperactive renin-angiotensin system (HP:0000841)1.77007191
131Flat acetabular roof (HP:0003180)1.76931479
132Wide cranial sutures (HP:0010537)1.75259932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.67585627
2ACVR1B5.27968578
3ERN14.38443287
4FGFR44.33974114
5SIK14.18450616
6TAOK33.15605541
7ERBB43.01552238
8INSRR2.89044948
9MST1R2.79321229
10FRK2.40263418
11PKN22.27835926
12MAP2K42.19076509
13PRPF4B2.07171874
14MAPK111.95089057
15FLT31.79389178
16LATS11.77297168
17PTK61.74040246
18PIK3CG1.72186721
19TRIB31.62967901
20TYK21.60993606
21GRK61.54598066
22ABL21.41880128
23STK391.38084280
24DAPK21.34974644
25TESK21.26276978
26MAP4K11.25004325
27PRKAA21.23959662
28NEK91.21498618
29MAP3K71.21304177
30KDR1.18815367
31MAP3K101.17140910
32ERBB21.15912183
33JAK21.15884252
34FGFR21.15785798
35PDK21.13568572
36TBK11.08268829
37MAP3K121.04818155
38MET1.04300100
39STK38L0.97297361
40DDR20.97222125
41MAPK40.96322684
42RIPK10.94163509
43JAK10.92671425
44MAP2K30.92084003
45MAP3K110.91005838
46NLK0.90971699
47OXSR10.90679138
48EPHB10.90030626
49PINK10.89904814
50MAP3K140.88348622
51PRKCZ0.87386439
52MAP3K30.84734817
53MAP2K60.84529231
54MATK0.83719338
55PBK0.81989369
56CDC42BPA0.80260797
57PRKACG0.77439847
58MAPK150.76994684
59CDK60.76673693
60CSK0.75331204
61CAMK2G0.74734829
62PRKAA10.72616440
63DYRK1B0.72556265
64MAP2K20.71624151
65MAPK120.69361576
66EPHA30.68048085
67SMG10.67680305
68FER0.67249120
69GSK3A0.66315925
70PIK3CA0.66065165
71PTK20.65851961
72IRAK10.65630175
73WNK40.62096209
74SGK30.60636410
75PDPK10.59620642
76IRAK30.58891329
77CAMK1D0.57628851
78TIE10.57535561
79PRKG20.57393197
80MAP2K10.56583572
81LMTK20.56268959
82PDGFRA0.54868782
83SRC0.54774433
84IKBKE0.54100819
85STK240.53357849
86GRK10.51792710
87MAPKAPK30.51260675
88EEF2K0.50946904
89KIT0.50595369
90AKT30.49860930
91MAPK70.49188650
92PRKCQ0.47935291
93ZAP700.47795656
94ICK0.47674574
95FGFR30.47036063
96MAP3K20.45793484
97MAP3K50.43645543
98MAP3K10.42211442
99CSNK1G10.42087114
100EPHB20.42042970
101TGFBR20.41971623
102TAOK10.40534126
103MAP3K60.40346594
104RET0.40040658
105IGF1R0.39623356
106MAP3K130.39557612
107TNIK0.39018721
108CSF1R0.38678876
109RIPK40.37993061
110TAOK20.37909951
111PDK10.36371694
112EPHA40.36304961
113EPHA20.34044481
114NUAK10.33572818
115CDK40.33498880
116PRKCA0.32737111
117SGK20.32733222
118MYLK0.32454254
119PRKACA0.31937452
120TESK10.31018886
121BMX0.30566955
122FYN0.30248290
123PRKG10.30192903
124MTOR0.29433814
125EGFR0.28807531
126CAMK2D0.28464429
127PRKCB0.26467064
128PDK30.25562248
129PDK40.25562248
130CAMK40.23988682
131PRKCG0.23599231
132SGK10.22883754
133PRKCD0.21255894
134KSR20.21181228
135PIM20.21015289
136MAPKAPK20.20522192
137PIM10.20179676
138SYK0.20134724

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.33525199
2Nitrogen metabolism_Homo sapiens_hsa009103.53479451
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41503785
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26595080
5Arginine biosynthesis_Homo sapiens_hsa002203.05228534
6Tryptophan metabolism_Homo sapiens_hsa003802.70241993
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63048658
8Complement and coagulation cascades_Homo sapiens_hsa046102.61123983
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53071305
10Fatty acid degradation_Homo sapiens_hsa000712.47198803
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43781842
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31077950
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29051755
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20111755
15Butanoate metabolism_Homo sapiens_hsa006502.09237625
16Peroxisome_Homo sapiens_hsa041462.02584689
17Chemical carcinogenesis_Homo sapiens_hsa052041.98960504
18Histidine metabolism_Homo sapiens_hsa003401.97186112
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97006448
20Caffeine metabolism_Homo sapiens_hsa002321.95876732
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.91222409
22PPAR signaling pathway_Homo sapiens_hsa033201.89760111
23Propanoate metabolism_Homo sapiens_hsa006401.84486127
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.77090146
25Fatty acid metabolism_Homo sapiens_hsa012121.75375378
26Retinol metabolism_Homo sapiens_hsa008301.69922670
27beta-Alanine metabolism_Homo sapiens_hsa004101.69495916
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67050110
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66660888
30Staphylococcus aureus infection_Homo sapiens_hsa051501.64351307
31Bile secretion_Homo sapiens_hsa049761.60413911
32Selenocompound metabolism_Homo sapiens_hsa004501.55220496
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54414089
34Phenylalanine metabolism_Homo sapiens_hsa003601.53083748
35Sulfur metabolism_Homo sapiens_hsa009201.52702024
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51953134
37Fat digestion and absorption_Homo sapiens_hsa049751.49305461
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43754846
39Starch and sucrose metabolism_Homo sapiens_hsa005001.41396608
40Tyrosine metabolism_Homo sapiens_hsa003501.37350864
41Pyruvate metabolism_Homo sapiens_hsa006201.36629206
42Folate biosynthesis_Homo sapiens_hsa007901.32189709
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.27823592
44Fatty acid elongation_Homo sapiens_hsa000621.27474239
45ABC transporters_Homo sapiens_hsa020101.22991176
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18518186
47Steroid biosynthesis_Homo sapiens_hsa001001.13953130
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.13738546
49Carbon metabolism_Homo sapiens_hsa012001.12567705
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.08137885
51Vitamin digestion and absorption_Homo sapiens_hsa049771.04534238
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01555284
53Arginine and proline metabolism_Homo sapiens_hsa003300.99677089
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96403656
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95047531
56Sulfur relay system_Homo sapiens_hsa041220.94214394
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91561933
58Vitamin B6 metabolism_Homo sapiens_hsa007500.82852257
59Lysine degradation_Homo sapiens_hsa003100.79918786
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75109194
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74928903
62Glutathione metabolism_Homo sapiens_hsa004800.74478569
63Glycerolipid metabolism_Homo sapiens_hsa005610.74249759
64One carbon pool by folate_Homo sapiens_hsa006700.67119184
65Pentose phosphate pathway_Homo sapiens_hsa000300.61953189
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52515119
67Fatty acid biosynthesis_Homo sapiens_hsa000610.50212644
68Metabolic pathways_Homo sapiens_hsa011000.46957293
69Galactose metabolism_Homo sapiens_hsa000520.44541750
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40090239
71Fructose and mannose metabolism_Homo sapiens_hsa000510.38520682
72Other glycan degradation_Homo sapiens_hsa005110.36812575
73Pertussis_Homo sapiens_hsa051330.34180296
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30876099
75Linoleic acid metabolism_Homo sapiens_hsa005910.27431822
76Prion diseases_Homo sapiens_hsa050200.26397580
77Insulin resistance_Homo sapiens_hsa049310.22115138
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.20490357
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.19593795
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13500134
81Renin-angiotensin system_Homo sapiens_hsa046140.07888154
82Glucagon signaling pathway_Homo sapiens_hsa049220.07756485
83Sphingolipid metabolism_Homo sapiens_hsa006000.07700786
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05338327
85Pancreatic secretion_Homo sapiens_hsa049720.02416253
86AMPK signaling pathway_Homo sapiens_hsa041520.01553643
87Mineral absorption_Homo sapiens_hsa049780.00091572
88Ether lipid metabolism_Homo sapiens_hsa00565-0.2255710
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2252204
90Bladder cancer_Homo sapiens_hsa05219-0.2158865
91Regulation of autophagy_Homo sapiens_hsa04140-0.1957775
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1952455
93Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1877721
94Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1839888
95Protein digestion and absorption_Homo sapiens_hsa04974-0.1652032
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1647886
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1549645
98Hepatitis C_Homo sapiens_hsa05160-0.1527451
99Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1504130
100Autoimmune thyroid disease_Homo sapiens_hsa05320-0.1354384
101African trypanosomiasis_Homo sapiens_hsa05143-0.1302159
102Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1249833
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1141907
104Allograft rejection_Homo sapiens_hsa05330-0.1101691
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1093328
106Serotonergic synapse_Homo sapiens_hsa04726-0.0924166
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0691676
108Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0455135
109Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0437941
110Amoebiasis_Homo sapiens_hsa05146-0.0411281
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0147342
112Asthma_Homo sapiens_hsa05310-0.0049077

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