NR1I3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.63592805
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.63592805
3L-phenylalanine metabolic process (GO:0006558)7.28738193
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28738193
5aromatic amino acid family catabolic process (GO:0009074)6.80470407
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.54108659
7tryptophan catabolic process (GO:0006569)6.09629482
8indole-containing compound catabolic process (GO:0042436)6.09629482
9indolalkylamine catabolic process (GO:0046218)6.09629482
10kynurenine metabolic process (GO:0070189)6.00132850
11bile acid biosynthetic process (GO:0006699)5.87566027
12omega-hydroxylase P450 pathway (GO:0097267)5.82613272
13tryptophan metabolic process (GO:0006568)5.75829178
14high-density lipoprotein particle remodeling (GO:0034375)5.70079085
15alpha-linolenic acid metabolic process (GO:0036109)5.62314602
16glyoxylate metabolic process (GO:0046487)5.61255430
17urea metabolic process (GO:0019627)5.59293528
18urea cycle (GO:0000050)5.59293528
19negative regulation of fibrinolysis (GO:0051918)5.49331732
20protein carboxylation (GO:0018214)5.32649986
21peptidyl-glutamic acid carboxylation (GO:0017187)5.32649986
22regulation of fibrinolysis (GO:0051917)5.31182242
23oxidative demethylation (GO:0070989)5.23431108
24cysteine metabolic process (GO:0006534)5.21281195
25sulfur amino acid catabolic process (GO:0000098)5.20184489
26nitrogen cycle metabolic process (GO:0071941)5.14119553
27bile acid metabolic process (GO:0008206)5.10998575
28serine family amino acid catabolic process (GO:0009071)5.07919923
29regulation of cholesterol esterification (GO:0010872)5.07656219
30regulation of protein activation cascade (GO:2000257)4.99827459
31complement activation, alternative pathway (GO:0006957)4.98827505
32aromatic amino acid family metabolic process (GO:0009072)4.94775132
33reverse cholesterol transport (GO:0043691)4.90884297
34regulation of triglyceride catabolic process (GO:0010896)4.86336322
35tyrosine metabolic process (GO:0006570)4.84458720
36protein-lipid complex remodeling (GO:0034368)4.84244118
37macromolecular complex remodeling (GO:0034367)4.84244118
38plasma lipoprotein particle remodeling (GO:0034369)4.84244118
39negative regulation of sterol transport (GO:0032372)4.82187911
40negative regulation of cholesterol transport (GO:0032375)4.82187911
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78364740
42S-adenosylmethionine metabolic process (GO:0046500)4.74043905
43phospholipid efflux (GO:0033700)4.69792202
44homocysteine metabolic process (GO:0050667)4.67666084
45triglyceride homeostasis (GO:0070328)4.66088176
46acylglycerol homeostasis (GO:0055090)4.66088176
47alpha-amino acid catabolic process (GO:1901606)4.65911809
48regulation of complement activation (GO:0030449)4.63678260
49amino-acid betaine metabolic process (GO:0006577)4.62445588
50lysine metabolic process (GO:0006553)4.56482983
51lysine catabolic process (GO:0006554)4.56482983
52cellular ketone body metabolic process (GO:0046950)4.52161012
53phenylpropanoid metabolic process (GO:0009698)4.51063159
54drug catabolic process (GO:0042737)4.43279271
55plasma lipoprotein particle clearance (GO:0034381)4.40207461
56imidazole-containing compound metabolic process (GO:0052803)4.39483230
57bile acid and bile salt transport (GO:0015721)4.39201833
58coenzyme catabolic process (GO:0009109)4.38127518
59glycine metabolic process (GO:0006544)4.37421372
60indolalkylamine metabolic process (GO:0006586)4.33236563
61cellular glucuronidation (GO:0052695)4.32101980
62cholesterol efflux (GO:0033344)4.31741049
63glutamate metabolic process (GO:0006536)4.27021706
64cellular amino acid catabolic process (GO:0009063)4.26874426
65cellular biogenic amine catabolic process (GO:0042402)4.24622336
66amine catabolic process (GO:0009310)4.24622336
67alkaloid metabolic process (GO:0009820)4.24075336
68benzene-containing compound metabolic process (GO:0042537)4.13522391
69serine family amino acid metabolic process (GO:0009069)4.10972669
70low-density lipoprotein particle remodeling (GO:0034374)4.07925333
71plasma lipoprotein particle assembly (GO:0034377)4.07096874
72arginine metabolic process (GO:0006525)4.03228092
73cellular modified amino acid catabolic process (GO:0042219)4.03200454
74ethanol oxidation (GO:0006069)4.01877106
75aldehyde catabolic process (GO:0046185)3.97546272
76regulation of bile acid biosynthetic process (GO:0070857)3.97482594
77serine family amino acid biosynthetic process (GO:0009070)3.96613772
78dicarboxylic acid biosynthetic process (GO:0043650)3.93785823
79fibrinolysis (GO:0042730)3.93062445
80ketone body metabolic process (GO:1902224)3.91372577
81negative regulation of lipase activity (GO:0060192)3.89606268
82exogenous drug catabolic process (GO:0042738)3.86315309
83uronic acid metabolic process (GO:0006063)3.83350075
84glucuronate metabolic process (GO:0019585)3.83350075
85positive regulation of lipid catabolic process (GO:0050996)3.83097324
86very-low-density lipoprotein particle assembly (GO:0034379)3.82583107
87flavonoid metabolic process (GO:0009812)3.81524990
88cofactor catabolic process (GO:0051187)3.81463821
89epoxygenase P450 pathway (GO:0019373)3.81397023
90water-soluble vitamin biosynthetic process (GO:0042364)3.81200067
91positive regulation of lipoprotein lipase activity (GO:0051006)3.79779778
92positive regulation of triglyceride lipase activity (GO:0061365)3.79779778
93cholesterol homeostasis (GO:0042632)3.79290435
94blood coagulation, intrinsic pathway (GO:0007597)3.77792004
95drug metabolic process (GO:0017144)3.76126047
96carboxylic acid catabolic process (GO:0046395)3.74979904
97organic acid catabolic process (GO:0016054)3.74979904
98short-chain fatty acid metabolic process (GO:0046459)3.73839077
99sterol homeostasis (GO:0055092)3.72870387
100regulation of cholesterol homeostasis (GO:2000188)3.68140740
101plasma lipoprotein particle organization (GO:0071827)3.67754631
102phospholipid homeostasis (GO:0055091)3.65979845
103protein-lipid complex assembly (GO:0065005)3.64533498
104intestinal cholesterol absorption (GO:0030299)3.64523450
105protein activation cascade (GO:0072376)3.58634449
106acetyl-CoA metabolic process (GO:0006084)3.58625991
107amino acid salvage (GO:0043102)3.55697927
108L-methionine salvage (GO:0071267)3.55697927
109L-methionine biosynthetic process (GO:0071265)3.55697927
110behavioral response to nicotine (GO:0035095)3.52709190
111pyrimidine nucleobase catabolic process (GO:0006208)3.39225748
112dopamine transport (GO:0015872)3.33412859
113regulation of hexokinase activity (GO:1903299)3.29198022
114regulation of glucokinase activity (GO:0033131)3.29198022
115protein K11-linked deubiquitination (GO:0035871)3.24431921
116arginine catabolic process (GO:0006527)3.17046783
117ethanol metabolic process (GO:0006067)3.14053026
118nucleobase catabolic process (GO:0046113)3.11462903
119negative regulation of telomere maintenance (GO:0032205)3.11035556
120heme transport (GO:0015886)3.05953974
121sulfation (GO:0051923)3.05573172
122indole-containing compound metabolic process (GO:0042430)3.03592777
123detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00387029
124steroid catabolic process (GO:0006706)2.94699459
125detection of light stimulus involved in visual perception (GO:0050908)2.92942919
126detection of light stimulus involved in sensory perception (GO:0050962)2.92942919
127peptidyl-glutamic acid modification (GO:0018200)2.90597545
128glycerophospholipid catabolic process (GO:0046475)2.86533928
129xenobiotic metabolic process (GO:0006805)2.82478268
130DNA deamination (GO:0045006)2.80534288
131positive regulation of fatty acid transport (GO:2000193)2.80327774
132organic cation transport (GO:0015695)2.78831604
133methionine biosynthetic process (GO:0009086)2.78749571
134protein complex biogenesis (GO:0070271)2.76137113
135drug transmembrane transport (GO:0006855)2.72606860
136vitamin biosynthetic process (GO:0009110)2.72039573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.47450469
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22454899
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.96344388
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.55556561
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.37638058
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.12923966
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.91292653
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.02402163
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00348997
10GBX2_23144817_ChIP-Seq_PC3_Human3.24981507
11ZNF274_21170338_ChIP-Seq_K562_Hela3.08175916
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84384133
13VDR_22108803_ChIP-Seq_LS180_Human2.60809773
14IGF1R_20145208_ChIP-Seq_DFB_Human2.45866770
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42493780
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23155996
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07764349
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03625420
19* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8838362
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99655089
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99378844
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98506312
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97159824
24ER_23166858_ChIP-Seq_MCF-7_Human1.97088994
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.92098403
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91076675
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80049540
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77151838
29P300_19829295_ChIP-Seq_ESCs_Human1.75076098
30FUS_26573619_Chip-Seq_HEK293_Human1.73098392
31EWS_26573619_Chip-Seq_HEK293_Human1.71583549
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69733579
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.59016838
34HTT_18923047_ChIP-ChIP_STHdh_Human1.56005283
35CLOCK_20551151_ChIP-Seq_293T_Human1.54121341
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.53785905
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53738122
38CBP_20019798_ChIP-Seq_JUKART_Human1.53738122
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.52318594
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52081638
41AR_25329375_ChIP-Seq_VCAP_Human1.50340764
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49577917
43TP53_22573176_ChIP-Seq_HFKS_Human1.49194196
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46359117
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.45073149
46EZH2_22144423_ChIP-Seq_EOC_Human1.44938351
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.42266052
48GATA1_22025678_ChIP-Seq_K562_Human1.41711493
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40668088
50* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39914642
51REST_21632747_ChIP-Seq_MESCs_Mouse1.39706240
52STAT3_23295773_ChIP-Seq_U87_Human1.39083846
53NANOG_19829295_ChIP-Seq_ESCs_Human1.38396782
54SOX2_19829295_ChIP-Seq_ESCs_Human1.38396782
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38275102
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.38275102
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37053559
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35734332
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35031400
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35014685
61TCF4_23295773_ChIP-Seq_U87_Human1.34468647
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34364958
63SMAD4_21799915_ChIP-Seq_A2780_Human1.32517689
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.31191379
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29412174
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29247609
67TCF4_22108803_ChIP-Seq_LS180_Human1.29135614
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28808394
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28294984
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25416360
71MYC_18940864_ChIP-ChIP_HL60_Human1.24295499
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.23094503
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21573954
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20003293
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19307421
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.19016275
77RUNX2_22187159_ChIP-Seq_PCA_Human1.18404276
78RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18046952
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17913932
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.17717646
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17396522
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.14471465
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.14084209
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13922469
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.12399763
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10843332
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10042272
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09722091
89MYC_19829295_ChIP-Seq_ESCs_Human1.09432400
90PHF8_20622853_ChIP-Seq_HELA_Human1.08892255
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08847240
92FOXH1_21741376_ChIP-Seq_EPCs_Human1.08247116
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.07242258
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06679070
95* P53_22387025_ChIP-Seq_ESCs_Mouse1.05284411
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04619348
97* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04476090
98ETV1_20927104_ChIP-Seq_GIST48_Human1.02385974
99* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02131523
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01554798
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01554773
102ERA_21632823_ChIP-Seq_H3396_Human1.01283987
103HOXB7_26014856_ChIP-Seq_BT474_Human1.00612386
104* STAT3_18555785_Chip-Seq_ESCs_Mouse1.00468779
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96962505
106TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96767552
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93430099
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87228399
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86597653
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85164964
111RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82702340
112GATA4_25053715_ChIP-Seq_YYC3_Human0.81294446
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81273225
114IRF8_22096565_ChIP-ChIP_GC-B_Human0.79026798
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78076582
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77864627
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74336300
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74118195
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.73922906
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.71804744
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69849995
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69324879
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69309301
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66141745
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65595856
126ZNF263_19887448_ChIP-Seq_K562_Human0.65543347
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.64672911
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63713979
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63008057
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.62783790
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62015780
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61592140
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61441318
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.60867059
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.60867059
136CEBPB_22108803_ChIP-Seq_LS180_Human0.58465580
137LXR_22292898_ChIP-Seq_THP-1_Human0.56310526
138* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53052949
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.51506517
140MYC_19915707_ChIP-ChIP_AK7_Human0.51426321
141AR_20517297_ChIP-Seq_VCAP_Human0.50798435
142EGR1_19032775_ChIP-ChIP_M12_Human0.50141478
143STAT1_17558387_ChIP-Seq_HELA_Human0.49594350
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49140122
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.49126508
146STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48976184
147CBP_21632823_ChIP-Seq_H3396_Human0.48563386
148FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48354652
149TAF15_26573619_Chip-Seq_HEK293_Human0.46623870
150CDX2_20551321_ChIP-Seq_CACO-2_Human0.46187611
151PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45748262
152* P53_21459846_ChIP-Seq_SAOS-2_Human0.44920147
153PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44669515
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44069167
155SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43980093
156GATA1_19941826_ChIP-Seq_K562_Human0.42583838
157GATA1_19941827_ChIP-Seq_MEL_Mouse0.42359613
158ERG_21242973_ChIP-ChIP_JURKAT_Human0.42146178
159TAF2_19829295_ChIP-Seq_ESCs_Human0.40464599
160GATA2_19941826_ChIP-Seq_K562_Human0.39865867
161BCAT_22108803_ChIP-Seq_LS180_Human0.39674551
162FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39660705
163PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39198655
164GATA6_25053715_ChIP-Seq_YYC3_Human0.39154551
165* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38780128
166ESR1_21235772_ChIP-Seq_MCF-7_Human0.38557963
167FOXO3_23340844_ChIP-Seq_DLD1_Human0.38527159
168MYC_27129775_Chip-Seq_CORNEA_Mouse0.38354245
169LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.37269211
170ESR1_20079471_ChIP-ChIP_T-47D_Human0.36448259
171STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36051181
172NCOR_22424771_ChIP-Seq_293T_Human0.35086339
173* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34375094
174SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.33962213
175CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33528866
176SPI1_26923725_Chip-Seq_HPCs_Mouse0.33144480
177OCT4_20526341_ChIP-Seq_ESCs_Human0.32742681
178CDX2_22108803_ChIP-Seq_LS180_Human0.32705909
179IRF1_19129219_ChIP-ChIP_H3396_Human0.32596529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.44355459
2MP0005360_urolithiasis7.53085305
3MP0005085_abnormal_gallbladder_physiolo6.50822230
4MP0005365_abnormal_bile_salt6.16067649
5* MP0008875_abnormal_xenobiotic_pharmacok5.21768945
6MP0003806_abnormal_nucleotide_metabolis4.14503734
7MP0003252_abnormal_bile_duct3.94167479
8MP0010329_abnormal_lipoprotein_level3.60983339
9MP0009840_abnormal_foam_cell3.38189741
10MP0005083_abnormal_biliary_tract3.08815314
11MP0003195_calcinosis2.90097327
12MP0005332_abnormal_amino_acid2.77031662
13MP0001666_abnormal_nutrient_absorption2.65392490
14MP0003191_abnormal_cellular_cholesterol2.24650020
15MP0004019_abnormal_vitamin_homeostasis2.16801168
16* MP0000609_abnormal_liver_physiology2.13688777
17* MP0002118_abnormal_lipid_homeostasis2.09275601
18MP0005551_abnormal_eye_electrophysiolog1.98838502
19MP0008877_abnormal_DNA_methylation1.91894427
20MP0002138_abnormal_hepatobiliary_system1.90299865
21MP0003868_abnormal_feces_composition1.88487973
22MP0005319_abnormal_enzyme/_coenzyme1.82886820
23MP0005646_abnormal_pituitary_gland1.75752309
24MP0002102_abnormal_ear_morphology1.75097790
25MP0001986_abnormal_taste_sensitivity1.74040909
26MP0001764_abnormal_homeostasis1.67054362
27MP0004043_abnormal_pH_regulation1.66106649
28MP0005451_abnormal_body_composition1.65030860
29MP0009745_abnormal_behavioral_response1.64355277
30MP0001968_abnormal_touch/_nociception1.64314976
31MP0005645_abnormal_hypothalamus_physiol1.61593401
32MP0009697_abnormal_copulation1.59210513
33MP0005584_abnormal_enzyme/coenzyme_acti1.56326530
34MP0001984_abnormal_olfaction1.46099581
35MP0004147_increased_porphyrin_level1.43624115
36MP0002163_abnormal_gland_morphology1.41071125
37MP0006072_abnormal_retinal_apoptosis1.37932908
38MP0009046_muscle_twitch1.36453484
39MP0004142_abnormal_muscle_tone1.35365457
40MP0002736_abnormal_nociception_after1.34728763
41MP0003787_abnormal_imprinting1.33111457
42MP0006292_abnormal_olfactory_placode1.32831577
43MP0003011_delayed_dark_adaptation1.31811015
44MP0003656_abnormal_erythrocyte_physiolo1.29369195
45MP0006276_abnormal_autonomic_nervous1.28962843
46MP0005379_endocrine/exocrine_gland_phen1.28459868
47MP0002272_abnormal_nervous_system1.26893702
48MP0003880_abnormal_central_pattern1.24391201
49MP0009643_abnormal_urine_homeostasis1.21826515
50MP0003186_abnormal_redox_activity1.21341006
51MP0003646_muscle_fatigue1.18936365
52MP0004133_heterotaxia1.17763886
53MP0000598_abnormal_liver_morphology1.17336615
54MP0001501_abnormal_sleep_pattern1.12152272
55MP0002064_seizures1.11176743
56MP0005647_abnormal_sex_gland1.10530530
57MP0003705_abnormal_hypodermis_morpholog1.08029750
58MP0009764_decreased_sensitivity_to1.08014352
59MP0000604_amyloidosis1.07393048
60MP0005187_abnormal_penis_morphology1.07101727
61MP0005389_reproductive_system_phenotype1.06649162
62MP0004885_abnormal_endolymph1.05380415
63MP0002638_abnormal_pupillary_reflex1.04155612
64MP0005253_abnormal_eye_physiology1.04033047
65MP0001905_abnormal_dopamine_level1.02973231
66MP0001919_abnormal_reproductive_system1.01744350
67MP0009763_increased_sensitivity_to1.01250174
68MP0001486_abnormal_startle_reflex1.00286897
69MP0002254_reproductive_system_inflammat0.99572927
70MP0010386_abnormal_urinary_bladder0.97391244
71MP0000372_irregular_coat_pigmentation0.94871320
72MP0002160_abnormal_reproductive_system0.93427405
73MP0002572_abnormal_emotion/affect_behav0.93062089
74MP0000427_abnormal_hair_cycle0.91931763
75MP0000569_abnormal_digit_pigmentation0.90551409
76MP0010368_abnormal_lymphatic_system0.90345870
77MP0003878_abnormal_ear_physiology0.90193237
78MP0005377_hearing/vestibular/ear_phenot0.90193237
79MP0005636_abnormal_mineral_homeostasis0.89927596
80MP0008469_abnormal_protein_level0.86957287
81* MP0009642_abnormal_blood_homeostasis0.86426586
82MP0005670_abnormal_white_adipose0.86305838
83MP0002938_white_spotting0.86033348
84MP0002557_abnormal_social/conspecific_i0.85931463
85MP0005386_behavior/neurological_phenoty0.84973899
86MP0004924_abnormal_behavior0.84973899
87MP0000631_abnormal_neuroendocrine_gland0.83578314
88MP0006036_abnormal_mitochondrial_physio0.83514397
89MP0004145_abnormal_muscle_electrophysio0.82295884
90MP0005408_hypopigmentation0.81336947
91MP0009765_abnormal_xenobiotic_induced0.80671412
92MP0002234_abnormal_pharynx_morphology0.80080844
93MP0005376_homeostasis/metabolism_phenot0.78840434
94MP0002876_abnormal_thyroid_physiology0.77591055
95MP0005084_abnormal_gallbladder_morpholo0.77471228
96* MP0002078_abnormal_glucose_homeostasis0.75792773
97MP0002971_abnormal_brown_adipose0.74883901
98MP0004742_abnormal_vestibular_system0.72964240
99MP0001970_abnormal_pain_threshold0.72301584
100MP0005410_abnormal_fertilization0.70707710
101MP0005334_abnormal_fat_pad0.70565752
102MP0001485_abnormal_pinna_reflex0.70445742
103MP0005195_abnormal_posterior_eye0.70387220
104MP0004130_abnormal_muscle_cell0.69310636
105MP0003690_abnormal_glial_cell0.68585504
106MP0002733_abnormal_thermal_nociception0.68563505
107MP0002909_abnormal_adrenal_gland0.67973145
108MP0005535_abnormal_body_temperature0.67530441
109MP0002229_neurodegeneration0.67018942
110MP0005423_abnormal_somatic_nervous0.66986169
111MP0002735_abnormal_chemical_nociception0.66447557
112MP0001661_extended_life_span0.66398768
113MP0005220_abnormal_exocrine_pancreas0.66035969
114MP0005266_abnormal_metabolism0.65352749
115MP0003329_amyloid_beta_deposits0.65056312
116MP0001529_abnormal_vocalization0.64349304
117MP0002822_catalepsy0.64241077
118MP0009053_abnormal_anal_canal0.63954819
119MP0002063_abnormal_learning/memory/cond0.63853052
120MP0000647_abnormal_sebaceous_gland0.63027768
121MP0008775_abnormal_heart_ventricle0.62650208
122MP0000639_abnormal_adrenal_gland0.59679731
123MP0005448_abnormal_energy_balance0.58381395
124MP0001756_abnormal_urination0.58222097
125MP0006035_abnormal_mitochondrial_morpho0.55629090
126MP0005464_abnormal_platelet_physiology0.51825140
127MP0008872_abnormal_physiological_respon0.49419721
128MP0003718_maternal_effect0.48001247
129MP0004782_abnormal_surfactant_physiolog0.47307644
130MP0005395_other_phenotype0.47306307
131MP0002136_abnormal_kidney_physiology0.44865352
132MP0002837_dystrophic_cardiac_calcinosis0.43864988
133MP0002928_abnormal_bile_duct0.43659039
134MP0003436_decreased_susceptibility_to0.42336170
135* MP0008874_decreased_physiological_sensi0.41901622
136MP0005248_abnormal_Harderian_gland0.41535545
137MP0003724_increased_susceptibility_to0.41268761
138MP0005666_abnormal_adipose_tissue0.39467248
139* MP0003953_abnormal_hormone_level0.39119396
140MP0003075_altered_response_to0.38954691
141* MP0008873_increased_physiological_sensi0.37849991
142MP0009672_abnormal_birth_weight0.36591025
143MP0005166_decreased_susceptibility_to0.35186015
144MP0009115_abnormal_fat_cell0.34072829
145MP0000230_abnormal_systemic_arterial0.33141230
146MP0000249_abnormal_blood_vessel0.32727545
147MP0001243_abnormal_dermal_layer0.32591122
148* MP0003638_abnormal_response/metabolism_0.32270399
149MP0001853_heart_inflammation0.32212953
150MP0006082_CNS_inflammation0.31826694
151MP0002970_abnormal_white_adipose0.30087544
152MP0002168_other_aberrant_phenotype0.29672543
153MP0004883_abnormal_blood_vessel0.29097004
154MP0000579_abnormal_nail_morphology0.28945681
155MP0002090_abnormal_vision0.27556250
156MP0002796_impaired_skin_barrier0.26875803
157MP0001881_abnormal_mammary_gland0.26292233
158MP0001845_abnormal_inflammatory_respons0.26219580
159MP0004381_abnormal_hair_follicle0.26159231
160MP0005167_abnormal_blood-brain_barrier0.24631459
161MP0009384_cardiac_valve_regurgitation0.23634112
162MP0002132_abnormal_respiratory_system0.22413288
163MP0002060_abnormal_skin_morphology0.21712642

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.57811089
2Deep venous thrombosis (HP:0002625)7.39329749
3Intrahepatic cholestasis (HP:0001406)7.12312119
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.75633612
5Hypobetalipoproteinemia (HP:0003563)6.56753575
6Prolonged partial thromboplastin time (HP:0003645)6.55798519
7Xanthomatosis (HP:0000991)6.31770480
8Hyperlipoproteinemia (HP:0010980)5.78319916
9Hypolipoproteinemia (HP:0010981)4.86889978
10Complement deficiency (HP:0004431)4.86143368
11Joint hemorrhage (HP:0005261)4.76646238
12Hyperammonemia (HP:0001987)4.62648986
13Epidermoid cyst (HP:0200040)4.53310280
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.46111783
15Abnormality of methionine metabolism (HP:0010901)4.39691865
16Hyperglycinemia (HP:0002154)4.36113654
17Abnormality of the common coagulation pathway (HP:0010990)4.33457665
18Ketosis (HP:0001946)4.33147848
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.27986761
20Hypoalphalipoproteinemia (HP:0003233)4.25810396
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.19810539
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.17293745
23Fat malabsorption (HP:0002630)3.99360962
24Hyperglycinuria (HP:0003108)3.95564580
25Abnormality of glycine metabolism (HP:0010895)3.94076818
26Abnormality of serine family amino acid metabolism (HP:0010894)3.94076818
27Abnormality of pyrimidine metabolism (HP:0004353)3.91401301
28Hypoglycemic coma (HP:0001325)3.86781337
29Hypercholesterolemia (HP:0003124)3.77674451
30Conjugated hyperbilirubinemia (HP:0002908)3.74458756
31Congenital stationary night blindness (HP:0007642)3.72424704
32Abnormality of the intrinsic pathway (HP:0010989)3.68844551
33Abnormality of complement system (HP:0005339)3.54268883
34Pancreatic cysts (HP:0001737)3.46422835
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40382322
36Hyperbilirubinemia (HP:0002904)3.38952190
37Abnormality of fatty-acid metabolism (HP:0004359)3.36208328
38Pancreatic fibrosis (HP:0100732)3.25673987
39Delayed CNS myelination (HP:0002188)3.17018869
40True hermaphroditism (HP:0010459)3.14092711
41Abnormality of nucleobase metabolism (HP:0010932)3.10065793
42Abnormality of serum amino acid levels (HP:0003112)3.04417247
43Ketoacidosis (HP:0001993)3.03447708
44Molar tooth sign on MRI (HP:0002419)3.00441419
45Abnormality of midbrain morphology (HP:0002418)3.00441419
46Steatorrhea (HP:0002570)2.98706516
47Myocardial infarction (HP:0001658)2.97927898
48Bile duct proliferation (HP:0001408)2.96455320
49Abnormal biliary tract physiology (HP:0012439)2.96455320
50Hepatocellular carcinoma (HP:0001402)2.95081245
51Spontaneous abortion (HP:0005268)2.93527012
52Chronic hepatic failure (HP:0100626)2.90713801
53Hyperventilation (HP:0002883)2.87641404
54Nephronophthisis (HP:0000090)2.85313537
55Fair hair (HP:0002286)2.83075184
56Hypochromic microcytic anemia (HP:0004840)2.82586347
57Metabolic acidosis (HP:0001942)2.81155222
58Skin nodule (HP:0200036)2.80071837
59Abnormality of the renal cortex (HP:0011035)2.72108910
60Abnormality of purine metabolism (HP:0004352)2.69398040
61Vascular calcification (HP:0004934)2.67498736
62Lethargy (HP:0001254)2.63718188
63Abnormality of urine glucose concentration (HP:0011016)2.62951127
64Glycosuria (HP:0003076)2.62951127
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62084665
66Dicarboxylic aciduria (HP:0003215)2.62084665
67Attenuation of retinal blood vessels (HP:0007843)2.61324727
68Acute encephalopathy (HP:0006846)2.54124316
69Abnormal rod and cone electroretinograms (HP:0008323)2.53322146
70Systemic lupus erythematosus (HP:0002725)2.53108776
71Acanthocytosis (HP:0001927)2.51754464
72Abolished electroretinogram (ERG) (HP:0000550)2.50676313
73Mitral stenosis (HP:0001718)2.49924509
74Abnormality of the renal medulla (HP:0100957)2.49124484
75Spastic diplegia (HP:0001264)2.47958694
76Abnormal gallbladder morphology (HP:0012437)2.47286647
77Cerebral edema (HP:0002181)2.47232423
78Hypoglycemic seizures (HP:0002173)2.46715194
79Glomerulonephritis (HP:0000099)2.43985202
80Mitochondrial inheritance (HP:0001427)2.43300697
81Increased CSF lactate (HP:0002490)2.42919138
82Cholelithiasis (HP:0001081)2.41355082
83Gout (HP:0001997)2.39553995
84Cardiovascular calcification (HP:0011915)2.36937851
85Irritability (HP:0000737)2.36704550
86Hepatic necrosis (HP:0002605)2.35030054
87Malnutrition (HP:0004395)2.33612584
88Hepatocellular necrosis (HP:0001404)2.32295844
89Polydipsia (HP:0001959)2.32060197
90Abnormal drinking behavior (HP:0030082)2.32060197
91Cholecystitis (HP:0001082)2.30777918
92Abnormal gallbladder physiology (HP:0012438)2.30777918
93Neonatal onset (HP:0003623)2.28686310
94Acute necrotizing encephalopathy (HP:0006965)2.27904047
95Congenital sensorineural hearing impairment (HP:0008527)2.27262920
96Amyloidosis (HP:0011034)2.25893463
97Hypothermia (HP:0002045)2.25594524
98Decreased central vision (HP:0007663)2.25111663
99Brushfield spots (HP:0001088)2.22641860
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21113960
101Abnormality of alanine metabolism (HP:0010916)2.21113960
102Hyperalaninemia (HP:0003348)2.21113960
103Lipid accumulation in hepatocytes (HP:0006561)2.19907924
104Menorrhagia (HP:0000132)2.17786590
105Generalized hypopigmentation of hair (HP:0011358)2.17226655
106Type II lissencephaly (HP:0007260)2.17205858
107Late onset (HP:0003584)2.17179750
108Cystic liver disease (HP:0006706)2.15846757
109Esophageal varix (HP:0002040)2.15671621
110Gingival bleeding (HP:0000225)2.14834367
111Progressive macrocephaly (HP:0004481)2.10499894
112Pancreatitis (HP:0001733)2.10213093
113Poikilocytosis (HP:0004447)2.09816173
114Enlarged kidneys (HP:0000105)2.09696596
115Vomiting (HP:0002013)2.09665926
116Opisthotonus (HP:0002179)2.08129041
117Sensorimotor neuropathy (HP:0007141)2.07079191
118Thrombophlebitis (HP:0004418)2.04109783
119Generalized aminoaciduria (HP:0002909)2.03912197
120Hemorrhage of the eye (HP:0011885)2.03885461
121Methylmalonic acidemia (HP:0002912)2.02744155
122Hyperinsulinemic hypoglycemia (HP:0000825)2.01685493
123Decreased circulating renin level (HP:0003351)2.01620143
124Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99726064
125Pendular nystagmus (HP:0012043)1.99021853
126Abnormality of the gallbladder (HP:0005264)1.98606797
127Recurrent gram-negative bacterial infections (HP:0005420)1.98535372
128Tubular atrophy (HP:0000092)1.97722524
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97350561
130Hypophosphatemic rickets (HP:0004912)1.96592179
131Polyuria (HP:0000103)1.95317806
132Hydroxyprolinuria (HP:0003080)1.94203091
133Abnormality of proline metabolism (HP:0010907)1.94203091
134Medial flaring of the eyebrow (HP:0010747)1.94059944
135Male pseudohermaphroditism (HP:0000037)1.93898923
136Rickets (HP:0002748)1.93773662
137Abnormality of iron homeostasis (HP:0011031)1.92403637
138Large for gestational age (HP:0001520)1.91353584
139Abnormality of transition element cation homeostasis (HP:0011030)1.88977608
140Increased serum lactate (HP:0002151)1.86873336
141Abnormal cartilage morphology (HP:0002763)1.86373910
142Abnormal mitochondria in muscle tissue (HP:0008316)1.86354382
143Renal cortical cysts (HP:0000803)1.86318364
144Status epilepticus (HP:0002133)1.86107674
145Arthropathy (HP:0003040)1.86009810
146Reduced antithrombin III activity (HP:0001976)1.85790636
147Limb dystonia (HP:0002451)1.85554713
148Abnormal urine output (HP:0012590)1.85507907
149Sclerocornea (HP:0000647)1.83581492
150Reticulocytosis (HP:0001923)1.81785149
151Alkalosis (HP:0001948)1.81516637
152Elevated hepatic transaminases (HP:0002910)1.80229608
153Bony spicule pigmentary retinopathy (HP:0007737)1.80050302
154CNS demyelination (HP:0007305)1.78190591
155Increased hepatocellular lipid droplets (HP:0006565)1.78142747
156Renal Fanconi syndrome (HP:0001994)1.76211840
157Abnormality of vitamin metabolism (HP:0100508)1.76118346
1583-Methylglutaconic aciduria (HP:0003535)1.75583665
159Hyperglycemia (HP:0003074)1.75520051
160Hyperphosphaturia (HP:0003109)1.75374956
161Nephritis (HP:0000123)1.73800458
162Broad-based gait (HP:0002136)1.73705257
163Optic disc pallor (HP:0000543)1.73642749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.31276980
2SIK14.75062393
3FGFR44.61273345
4ERN14.16610599
5MAP4K23.26413308
6WNK33.14248841
7TLK13.07402126
8TAOK33.05094858
9INSRR3.04711133
10ADRBK23.02079124
11ERBB42.60196415
12ZAK2.47655483
13PKN22.47173564
14MAP2K42.43145391
15CASK2.37526004
16NUAK12.34823461
17MST1R2.18086827
18WNK42.06843949
19FLT32.02994828
20BMPR1B1.89335547
21PIK3CG1.81225474
22TRIB31.75485899
23TXK1.75463490
24MAPK111.73577968
25OXSR11.72092145
26TYK21.68751158
27MAPK131.60565244
28DAPK21.60434002
29ABL21.48332187
30PTK61.47868292
31LATS11.46946627
32FRK1.40041558
33FGFR21.39848842
34KDR1.38541332
35STK391.38411521
36MST41.37529339
37DYRK21.33387631
38TNIK1.32464048
39NTRK31.29396719
40PAK31.24236571
41NEK91.23019507
42JAK21.20286089
43MAP3K71.17625200
44PRKAA21.15583379
45GRK61.15004234
46PINK11.14074841
47ACVR1B1.12529979
48PHKG21.12187398
49PHKG11.12187398
50MAP3K41.12070550
51MAP2K31.11288534
52TRIM281.10817117
53TBK11.09046636
54MAPK41.03972516
55MAP3K140.99507768
56MAPKAPK30.98677136
57JAK10.98316710
58PRKCZ0.96345699
59ERBB20.96268675
60MAP3K100.93660996
61MAPK150.93208920
62PRKCE0.93157573
63ADRBK10.89409859
64NME10.88181431
65MAP3K110.87500206
66PLK20.87479404
67CAMKK20.86660310
68EIF2AK30.86639584
69MAPK120.86179288
70TAF10.84506733
71CSK0.83252907
72MAP3K30.82650774
73EPHB10.82401122
74MET0.81847904
75CDK60.80888494
76MAP2K60.80330262
77MAPKAPK50.80257098
78STK160.77047446
79STK38L0.76668837
80PRKACG0.75617263
81DYRK1B0.75408360
82TIE10.74337071
83VRK10.74161420
84EPHA40.72161939
85IKBKB0.69056110
86IRAK30.68921647
87SIK20.68514855
88CAMK2G0.66913978
89EPHA30.66427897
90MAP2K70.66093284
91MKNK20.65577839
92GSK3A0.64738514
93VRK20.63787237
94SGK30.63581864
95PRKAA10.63460493
96MARK10.62558536
97BCR0.61394045
98MAPK70.60339169
99GRK70.59470546
100PRKACA0.59174034
101PRKCI0.58985419
102CSNK1A10.57408613
103CAMK1D0.56738049
104ERBB30.56470761
105BRSK20.56277939
106TGFBR20.55619270
107TAOK20.55591142
108PRKG10.55513234
109MUSK0.55463482
110STK110.55120537
111PTK20.54938218
112RIPK10.54241512
113IKBKE0.54073041
114PRKCQ0.53752405
115PTK2B0.53175795
116CSF1R0.52496579
117PLK40.52200378
118PDPK10.51839005
119FGFR30.51769810
120CSNK1G10.50566346
121FER0.48904531
122CAMK2A0.48305605
123MAP3K50.47215887
124SGK20.45422294
125PLK30.44832503
126GRK10.44825185
127CAMK10.44647773
128IGF1R0.43951119
129GRK50.43503093
130CSNK1D0.42518492
131TRPM70.42473788
132RET0.42144037
133CDK40.41988413
134KIT0.41867654
135STK30.41671700
136EIF2AK20.41508077
137PNCK0.40941504
138PRKCG0.40864000
139RPS6KA50.39071126
140MAP3K130.38767033
141MAP2K10.37797504
142MAP3K60.37299239
143WEE10.36747016
144ICK0.35439173
145OBSCN0.33930469
146PBK0.33236230
147AKT30.33130851
148CAMK40.33000597
149MAP3K120.32812081
150MINK10.32601600
151MTOR0.32022141
152PDK10.31965756
153CAMK2D0.31282860
154CHUK0.31278057
155CSNK1G20.30636683
156SGK2230.29767146
157SGK4940.29767146
158IRAK20.28834097
159EGFR0.28642496
160PIK3CA0.28125545
161PKN10.28089359
162MAP3K10.26967244
163CSNK1G30.26788610
164IRAK10.24326534
165* PRKCA0.22970353
166MAP2K20.22727152
167PDK30.20695680
168PDK40.20695680
169LATS20.19724273
170CSNK1A1L0.19360108

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.43243272
2Nitrogen metabolism_Homo sapiens_hsa009103.48657069
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44900725
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.33563919
5Arginine biosynthesis_Homo sapiens_hsa002203.04769923
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77528339
7Tryptophan metabolism_Homo sapiens_hsa003802.71402549
8Complement and coagulation cascades_Homo sapiens_hsa046102.63614005
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56994411
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49511314
11Fatty acid degradation_Homo sapiens_hsa000712.48278730
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36503870
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33738738
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23102664
15Butanoate metabolism_Homo sapiens_hsa006502.14521973
16Peroxisome_Homo sapiens_hsa041462.06172977
17Chemical carcinogenesis_Homo sapiens_hsa052042.03691583
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.02715278
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02016041
20Caffeine metabolism_Homo sapiens_hsa002321.98124208
21Histidine metabolism_Homo sapiens_hsa003401.93779205
22Propanoate metabolism_Homo sapiens_hsa006401.89176847
23PPAR signaling pathway_Homo sapiens_hsa033201.88244052
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.83945683
25Retinol metabolism_Homo sapiens_hsa008301.77995258
26Fatty acid metabolism_Homo sapiens_hsa012121.77488578
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72734194
28beta-Alanine metabolism_Homo sapiens_hsa004101.72140367
29Staphylococcus aureus infection_Homo sapiens_hsa051501.71517285
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71259044
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60693456
32Selenocompound metabolism_Homo sapiens_hsa004501.56535442
33Phenylalanine metabolism_Homo sapiens_hsa003601.55275401
34Bile secretion_Homo sapiens_hsa049761.53488671
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50978134
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50433087
37Tyrosine metabolism_Homo sapiens_hsa003501.41624039
38Oxidative phosphorylation_Homo sapiens_hsa001901.39472286
39Pyruvate metabolism_Homo sapiens_hsa006201.35075130
40Fatty acid elongation_Homo sapiens_hsa000621.32782982
41Sulfur metabolism_Homo sapiens_hsa009201.32212975
42Starch and sucrose metabolism_Homo sapiens_hsa005001.30771594
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.30045743
44Folate biosynthesis_Homo sapiens_hsa007901.23964906
45Phototransduction_Homo sapiens_hsa047441.22829564
46ABC transporters_Homo sapiens_hsa020101.22584537
47Fat digestion and absorption_Homo sapiens_hsa049751.20032238
48Biosynthesis of amino acids_Homo sapiens_hsa012301.17931217
49Steroid biosynthesis_Homo sapiens_hsa001001.15648152
50Carbon metabolism_Homo sapiens_hsa012001.09376502
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07569731
52Protein export_Homo sapiens_hsa030601.03161556
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.00841453
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00410438
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99320044
56Arginine and proline metabolism_Homo sapiens_hsa003300.98806779
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.98804604
58Parkinsons disease_Homo sapiens_hsa050120.98687142
59Sulfur relay system_Homo sapiens_hsa041220.94851489
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88334675
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85977131
62Vitamin digestion and absorption_Homo sapiens_hsa049770.85334734
63Vitamin B6 metabolism_Homo sapiens_hsa007500.84478929
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82171132
65Lysine degradation_Homo sapiens_hsa003100.81552056
66Nicotine addiction_Homo sapiens_hsa050330.78960005
67One carbon pool by folate_Homo sapiens_hsa006700.75169021
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68934543
69Serotonergic synapse_Homo sapiens_hsa047260.68723508
70Glycerolipid metabolism_Homo sapiens_hsa005610.68672374
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67762553
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67229376
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65855892
74Glutathione metabolism_Homo sapiens_hsa004800.62749982
75Homologous recombination_Homo sapiens_hsa034400.62192313
76RNA polymerase_Homo sapiens_hsa030200.54381249
77Alzheimers disease_Homo sapiens_hsa050100.54203070
78Pentose phosphate pathway_Homo sapiens_hsa000300.54121116
79Fanconi anemia pathway_Homo sapiens_hsa034600.49417353
80Fatty acid biosynthesis_Homo sapiens_hsa000610.47878747
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46588596
82Metabolic pathways_Homo sapiens_hsa011000.46145364
83Huntingtons disease_Homo sapiens_hsa050160.45810577
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45100895
85Basal transcription factors_Homo sapiens_hsa030220.41364394
86Cardiac muscle contraction_Homo sapiens_hsa042600.39018972
87Proteasome_Homo sapiens_hsa030500.37202211
88Morphine addiction_Homo sapiens_hsa050320.35894880
89GABAergic synapse_Homo sapiens_hsa047270.34955127
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.34479007
91Collecting duct acid secretion_Homo sapiens_hsa049660.34365659
92Taste transduction_Homo sapiens_hsa047420.34084121
93Insulin secretion_Homo sapiens_hsa049110.33306929
94Mineral absorption_Homo sapiens_hsa049780.31868779
95Olfactory transduction_Homo sapiens_hsa047400.31174319
96Linoleic acid metabolism_Homo sapiens_hsa005910.28737232
97Galactose metabolism_Homo sapiens_hsa000520.26298937
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25678723
99Insulin resistance_Homo sapiens_hsa049310.23255792
100Fructose and mannose metabolism_Homo sapiens_hsa000510.22871135
101Prion diseases_Homo sapiens_hsa050200.22637926
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.21188399
103RNA degradation_Homo sapiens_hsa030180.20689828
104Glutamatergic synapse_Homo sapiens_hsa047240.19941184
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17029653
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16857427
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.15992051
108Glucagon signaling pathway_Homo sapiens_hsa049220.10133210
109AMPK signaling pathway_Homo sapiens_hsa041520.02296118
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2580210
111Ether lipid metabolism_Homo sapiens_hsa00565-0.2511593
112Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2457508
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2446916
114Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2414509
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1977919
116Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1976991
117Hepatitis C_Homo sapiens_hsa05160-0.1941170
118Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1919829
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1744567
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1666402
121Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1656379
122Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1583214
123Renin-angiotensin system_Homo sapiens_hsa04614-0.1521600
124Regulation of autophagy_Homo sapiens_hsa04140-0.1487395
125African trypanosomiasis_Homo sapiens_hsa05143-0.1385442
126Insulin signaling pathway_Homo sapiens_hsa04910-0.1077024
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1075818
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0939364
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0555047
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0096501

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