NR2C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.34595841
2L-phenylalanine catabolic process (GO:0006559)5.34595841
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.26084887
4L-phenylalanine metabolic process (GO:0006558)5.26084887
5lysine catabolic process (GO:0006554)5.10092856
6lysine metabolic process (GO:0006553)5.10092856
7alpha-linolenic acid metabolic process (GO:0036109)4.86422185
8protein carboxylation (GO:0018214)4.80467383
9peptidyl-glutamic acid carboxylation (GO:0017187)4.80467383
10urea cycle (GO:0000050)4.79260623
11urea metabolic process (GO:0019627)4.79260623
12aromatic amino acid family catabolic process (GO:0009074)4.78810835
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.72779862
14tryptophan metabolic process (GO:0006568)4.52736940
15bile acid biosynthetic process (GO:0006699)4.48116524
16indole-containing compound catabolic process (GO:0042436)4.41863985
17indolalkylamine catabolic process (GO:0046218)4.41863985
18tryptophan catabolic process (GO:0006569)4.41863985
19negative regulation of fibrinolysis (GO:0051918)4.39190147
20glyoxylate metabolic process (GO:0046487)4.35154510
21amino-acid betaine metabolic process (GO:0006577)4.27707453
22nitrogen cycle metabolic process (GO:0071941)4.25858174
23regulation of protein activation cascade (GO:2000257)4.22780390
24complement activation, alternative pathway (GO:0006957)4.05722109
25high-density lipoprotein particle remodeling (GO:0034375)4.05210696
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.01971787
27kynurenine metabolic process (GO:0070189)4.01565012
28regulation of complement activation (GO:0030449)4.00180807
29aldehyde catabolic process (GO:0046185)3.98311043
30regulation of triglyceride catabolic process (GO:0010896)3.96413516
31regulation of fibrinolysis (GO:0051917)3.92149721
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.89047462
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.89047462
34cysteine metabolic process (GO:0006534)3.86671227
35DNA double-strand break processing (GO:0000729)3.82235967
36sulfur amino acid catabolic process (GO:0000098)3.79551294
37plasma lipoprotein particle clearance (GO:0034381)3.77834063
38serine family amino acid biosynthetic process (GO:0009070)3.66885572
39disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.65395931
40killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.65395931
41reverse cholesterol transport (GO:0043691)3.64054964
42bile acid metabolic process (GO:0008206)3.61491044
43chromatin remodeling at centromere (GO:0031055)3.58282627
44L-serine metabolic process (GO:0006563)3.58242390
45coenzyme catabolic process (GO:0009109)3.58185077
46homocysteine metabolic process (GO:0050667)3.53181445
47aromatic amino acid family metabolic process (GO:0009072)3.50847081
48phospholipid efflux (GO:0033700)3.50343754
49carnitine metabolic process (GO:0009437)3.49899534
50protein-lipid complex remodeling (GO:0034368)3.47368188
51macromolecular complex remodeling (GO:0034367)3.47368188
52plasma lipoprotein particle remodeling (GO:0034369)3.47368188
53fibrinolysis (GO:0042730)3.46701056
54CENP-A containing nucleosome assembly (GO:0034080)3.45859853
55triglyceride homeostasis (GO:0070328)3.41673430
56acylglycerol homeostasis (GO:0055090)3.41673430
57one-carbon metabolic process (GO:0006730)3.41610533
58response to pheromone (GO:0019236)3.38760015
59kinetochore assembly (GO:0051382)3.38751533
60aspartate family amino acid catabolic process (GO:0009068)3.36674125
61replication fork processing (GO:0031297)3.36383189
62cofactor catabolic process (GO:0051187)3.35942950
63alpha-amino acid catabolic process (GO:1901606)3.35308512
64tyrosine metabolic process (GO:0006570)3.35167372
65cholesterol efflux (GO:0033344)3.33665268
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.30840163
67regulation of sequestering of triglyceride (GO:0010889)3.30334291
68negative regulation of cholesterol transport (GO:0032375)3.26550225
69negative regulation of sterol transport (GO:0032372)3.26550225
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.21085784
71regulation of mitotic spindle checkpoint (GO:1903504)3.21085784
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.20751990
73positive regulation of fatty acid beta-oxidation (GO:0032000)3.20321888
74glycine metabolic process (GO:0006544)3.18678639
75protein prenylation (GO:0018342)3.18622963
76prenylation (GO:0097354)3.18622963
77lipoprotein metabolic process (GO:0042157)3.15187202
78negative regulation of DNA recombination (GO:0045910)3.14902470
79bile acid and bile salt transport (GO:0015721)3.12630948
80negative regulation of lipase activity (GO:0060192)3.12464821
81plasma lipoprotein particle assembly (GO:0034377)3.12403191
82imidazole-containing compound metabolic process (GO:0052803)3.11876895
83negative regulation of DNA-dependent DNA replication (GO:2000104)3.11792986
84protein-cofactor linkage (GO:0018065)3.11098021
85regulation of meiosis I (GO:0060631)3.10131396
86protein K11-linked deubiquitination (GO:0035871)3.09212777
87regulation of response to tumor cell (GO:0002834)3.08531370
88positive regulation of response to tumor cell (GO:0002836)3.08531370
89positive regulation of immune response to tumor cell (GO:0002839)3.08531370
90regulation of immune response to tumor cell (GO:0002837)3.08531370
91misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.08318823
92indolalkylamine metabolic process (GO:0006586)3.08103712
93regulation of cholesterol esterification (GO:0010872)3.07244416
94cellular amino acid catabolic process (GO:0009063)3.07109519
95ethanol oxidation (GO:0006069)3.06996741
96epoxygenase P450 pathway (GO:0019373)3.06827674
97positive regulation of lipid catabolic process (GO:0050996)3.05740953
98kinetochore organization (GO:0051383)3.05714260
99disruption of cells of other organism (GO:0044364)3.05070202
100killing of cells of other organism (GO:0031640)3.05070202
101serine family amino acid metabolic process (GO:0009069)3.04902129
102cholesterol homeostasis (GO:0042632)3.04697738
103serine family amino acid catabolic process (GO:0009071)3.03080693
104sterol homeostasis (GO:0055092)3.02281081
105primary alcohol catabolic process (GO:0034310)3.01590886
1064-hydroxyproline metabolic process (GO:0019471)3.00241968
107neural tube formation (GO:0001841)3.00208737
108arginine metabolic process (GO:0006525)3.00090846
109cellular glucuronidation (GO:0052695)2.98940945
110reciprocal meiotic recombination (GO:0007131)2.98593866
111reciprocal DNA recombination (GO:0035825)2.98593866
112histone exchange (GO:0043486)2.98134480
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96988000
114epithelial cilium movement (GO:0003351)2.95064451
115respiratory chain complex IV assembly (GO:0008535)2.93369665
116exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93083370
117positive regulation of lipoprotein lipase activity (GO:0051006)2.91885479
118positive regulation of triglyceride lipase activity (GO:0061365)2.91885479
119recombinational repair (GO:0000725)2.91645278
120histone H2A acetylation (GO:0043968)2.91291218
121DNA integration (GO:0015074)2.88707220
122L-methionine salvage (GO:0071267)2.88526241
123L-methionine biosynthetic process (GO:0071265)2.88526241
124amino acid salvage (GO:0043102)2.88526241
125organelle disassembly (GO:1903008)2.88510624
126intestinal cholesterol absorption (GO:0030299)2.87740144
127double-strand break repair via homologous recombination (GO:0000724)2.87191047
128regulation of plasminogen activation (GO:0010755)2.87013178
129DNA replication-dependent nucleosome organization (GO:0034723)2.84903250
130DNA replication-dependent nucleosome assembly (GO:0006335)2.84903250
131regulation of helicase activity (GO:0051095)2.84544797
132ethanol metabolic process (GO:0006067)2.84436427
133fatty acid beta-oxidation (GO:0006635)2.84343056
134fatty acid oxidation (GO:0019395)2.84214023
135regulation of centriole replication (GO:0046599)2.83071855
136epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82908100
137plasma lipoprotein particle organization (GO:0071827)2.81497687
138amine catabolic process (GO:0009310)2.80683745
139cellular biogenic amine catabolic process (GO:0042402)2.80683745
140protein-lipid complex assembly (GO:0065005)2.80168060
141positive regulation of fatty acid oxidation (GO:0046321)2.79566437
142platelet dense granule organization (GO:0060155)2.78958706
143retinal cone cell development (GO:0046549)2.75494869
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.73972662
145water-soluble vitamin biosynthetic process (GO:0042364)2.73603145
146S-adenosylmethionine metabolic process (GO:0046500)2.71073562
147somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.70855201
148somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.70855201
149isotype switching (GO:0045190)2.70855201
150regulation of glucokinase activity (GO:0033131)2.70780053
151regulation of hexokinase activity (GO:1903299)2.70780053
152ribonucleoprotein complex disassembly (GO:0032988)2.70392708
153nonmotile primary cilium assembly (GO:0035058)2.69441189
154maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69392536
155rRNA catabolic process (GO:0016075)2.69306623
156resolution of meiotic recombination intermediates (GO:0000712)2.69040409
157regulation of collateral sprouting (GO:0048670)2.68962861
158piRNA metabolic process (GO:0034587)2.68226668
159DNA replication-independent nucleosome organization (GO:0034724)2.67403696
160DNA replication-independent nucleosome assembly (GO:0006336)2.67403696
161DNA deamination (GO:0045006)2.66854007
162centriole replication (GO:0007099)2.66806832
163cilium morphogenesis (GO:0060271)2.65213550
164limb bud formation (GO:0060174)2.64931952
165regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.63361179
166intraciliary transport (GO:0042073)2.60128171
167ncRNA catabolic process (GO:0034661)2.60057759
168cullin deneddylation (GO:0010388)2.59432646
169microtubule anchoring (GO:0034453)2.57525613
170branched-chain amino acid catabolic process (GO:0009083)2.55682885
171peptidyl-histidine modification (GO:0018202)2.55486586
172mismatch repair (GO:0006298)2.54178201
173negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53859866
174negative regulation of translation, ncRNA-mediated (GO:0040033)2.53859866
175regulation of translation, ncRNA-mediated (GO:0045974)2.53859866
176histone mRNA metabolic process (GO:0008334)2.51097364
177postreplication repair (GO:0006301)2.50814764
178protein deneddylation (GO:0000338)2.50690857
179presynaptic membrane assembly (GO:0097105)2.50423663
180protein localization to cilium (GO:0061512)2.50382362
181photoreceptor cell maintenance (GO:0045494)2.49169722
182proteasome assembly (GO:0043248)2.49054839
183regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.46209930
184DNA catabolic process, exonucleolytic (GO:0000738)2.44766626
185cytochrome complex assembly (GO:0017004)2.44181472
186nucleotide-excision repair, DNA gap filling (GO:0006297)2.44124596
187somatic diversification of immunoglobulins (GO:0016445)2.43973545
188L-fucose catabolic process (GO:0042355)2.43648202
189fucose catabolic process (GO:0019317)2.43648202
190L-fucose metabolic process (GO:0042354)2.43648202
191C4-dicarboxylate transport (GO:0015740)2.43391536
192presynaptic membrane organization (GO:0097090)2.43250679
193protein K6-linked ubiquitination (GO:0085020)2.42800043
194pyrimidine dimer repair (GO:0006290)2.42530819
195regulation of telomere maintenance (GO:0032204)2.41909454
196otic vesicle formation (GO:0030916)2.40282356
197behavioral response to nicotine (GO:0035095)2.39964064
198mitochondrial respiratory chain complex I assembly (GO:0032981)2.39922128
199NADH dehydrogenase complex assembly (GO:0010257)2.39922128
200mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.39922128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.87556499
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.53557615
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.82921767
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.76604196
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.31557738
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.10230040
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.89256071
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.77635570
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.18296412
10ZNF274_21170338_ChIP-Seq_K562_Hela3.02476384
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99664046
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.96985280
13IGF1R_20145208_ChIP-Seq_DFB_Human2.96183807
14GATA1_22025678_ChIP-Seq_K562_Human2.81716326
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76621715
16VDR_22108803_ChIP-Seq_LS180_Human2.68334932
17FUS_26573619_Chip-Seq_HEK293_Human2.62302006
18GBX2_23144817_ChIP-Seq_PC3_Human2.54543477
19EWS_26573619_Chip-Seq_HEK293_Human2.51768256
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.47590124
21TAF15_26573619_Chip-Seq_HEK293_Human2.44613855
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42971377
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.41867493
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41390888
25* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36359200
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.27366581
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24619059
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24560779
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19504347
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.15356993
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14523272
32CLOCK_20551151_ChIP-Seq_293T_Human2.13670409
33IRF8_22096565_ChIP-ChIP_GC-B_Human2.13154323
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13150815
35ELK1_19687146_ChIP-ChIP_HELA_Human2.11559272
36MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06348634
37P300_19829295_ChIP-Seq_ESCs_Human2.06076496
38SCL_19346495_ChIP-Seq_HPC-7_Human1.95346658
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93992314
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93935291
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91238517
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88276595
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.83428314
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81963993
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76522471
46E2F7_22180533_ChIP-Seq_HELA_Human1.74391308
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70104067
48* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66421232
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65437408
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64337740
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63709110
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63653390
53TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62252646
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.61645955
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.60539863
56VDR_23849224_ChIP-Seq_CD4+_Human1.60285396
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60223605
58* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59333334
59ER_23166858_ChIP-Seq_MCF-7_Human1.58457605
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56921239
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55804144
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51508592
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51344576
64IRF1_19129219_ChIP-ChIP_H3396_Human1.50091893
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49855814
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49101008
67MYC_18940864_ChIP-ChIP_HL60_Human1.48865710
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47955998
69* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45516085
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45139136
71CBP_20019798_ChIP-Seq_JUKART_Human1.44920373
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44920373
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44336033
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43074352
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40835675
76SMAD4_21799915_ChIP-Seq_A2780_Human1.38733477
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38184888
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37790589
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36006443
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35794447
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35565577
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.35325508
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34729224
84STAT3_23295773_ChIP-Seq_U87_Human1.33918081
85EZH2_22144423_ChIP-Seq_EOC_Human1.32264590
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31380659
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31131467
88FOXP3_21729870_ChIP-Seq_TREG_Human1.30537623
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29205550
90ETS1_20019798_ChIP-Seq_JURKAT_Human1.25218367
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24915984
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.23733848
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23630785
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.23547960
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23086737
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23042923
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.22035150
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21079100
99TP53_22573176_ChIP-Seq_HFKS_Human1.20478603
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18771811
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18543447
102* TCF4_23295773_ChIP-Seq_U87_Human1.18438673
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.17820095
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17598139
105AR_25329375_ChIP-Seq_VCAP_Human1.17480048
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17135035
107NANOG_19829295_ChIP-Seq_ESCs_Human1.16055863
108SOX2_19829295_ChIP-Seq_ESCs_Human1.16055863
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14516296
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.14463385
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12841906
112JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12195938
113TCF4_22108803_ChIP-Seq_LS180_Human1.11850446
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11718958
115AR_21909140_ChIP-Seq_LNCAP_Human1.11637084
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11490760
117BCAT_22108803_ChIP-Seq_LS180_Human1.11317327
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10437449
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10098372
120RNF2_27304074_Chip-Seq_NSC_Mouse1.09657125
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09499086
122NANOG_18555785_Chip-Seq_ESCs_Mouse1.09128203
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09086625
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08193905
125RUNX2_22187159_ChIP-Seq_PCA_Human1.07551801
126HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06723750
127EGR1_19374776_ChIP-ChIP_THP-1_Human1.06046771
128STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05863631
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05486381
130* PU_27001747_Chip-Seq_BMDM_Mouse1.04699933
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04548566
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04548566
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04085688
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03946569
135NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03643650
136RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03440579
137* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02981793
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02949727
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02931577
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02654103
141TP63_19390658_ChIP-ChIP_HaCaT_Human1.02446674
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00078830
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.99917494
144* CRX_20693478_ChIP-Seq_RETINA_Mouse0.99652129
145SRF_21415370_ChIP-Seq_HL-1_Mouse0.98756850
146* FLI1_21867929_ChIP-Seq_TH2_Mouse0.98737193
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98406031
148HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97955475
149NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97761085
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97198096
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96839141
152PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96243061
153SOX2_16153702_ChIP-ChIP_HESCs_Human0.96180925
154P53_22387025_ChIP-Seq_ESCs_Mouse0.96067085
155HNF4A_19822575_ChIP-Seq_HepG2_Human0.95169379
156FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95052291
157SPI1_23547873_ChIP-Seq_NB4_Human0.94496029
158* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94294923
159GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93326077
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92351876
161EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91704307
162MYB_26560356_Chip-Seq_TH1_Human0.90993257
163PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90310768
164GATA4_25053715_ChIP-Seq_YYC3_Human0.87525876
165SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86762954
166GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86685859
167FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86637179
168FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86279929
169MYB_26560356_Chip-Seq_TH2_Human0.84735100
170LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83623912
171ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81665010
172PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80889580
173* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80737431
174PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80279423
175DCP1A_22483619_ChIP-Seq_HELA_Human0.79427947
176MYC_18555785_ChIP-Seq_MESCs_Mouse0.79422207
177PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.78520483
178* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78364808
179TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78266328
180AR_20517297_ChIP-Seq_VCAP_Human0.77839580
181NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77796262
182NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77796262
183VDR_24763502_ChIP-Seq_THP-1_Human0.76787651
184PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72886774
185GATA3_26560356_Chip-Seq_TH2_Human0.71449246
186SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70820210
187CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.70576882
188E2F1_18555785_ChIP-Seq_MESCs_Mouse0.70376582
189STAT4_19710469_ChIP-ChIP_TH1__Mouse0.70359130
190* BRD4_25478319_ChIP-Seq_HGPS_Human0.69410096
191TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69260832
192* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68641780
193CJUN_26792858_Chip-Seq_BT549_Human0.68080632
194RXRA_24833708_ChIP-Seq_LIVER_Mouse0.67630723
195RUNX1_22412390_ChIP-Seq_EML_Mouse0.67049965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.44851242
2MP0002139_abnormal_hepatobiliary_system5.43906176
3MP0005365_abnormal_bile_salt5.18040904
4MP0005085_abnormal_gallbladder_physiolo4.55178778
5MP0008877_abnormal_DNA_methylation3.61499985
6MP0008875_abnormal_xenobiotic_pharmacok3.51138252
7MP0003787_abnormal_imprinting3.35216583
8MP0006292_abnormal_olfactory_placode3.01327777
9MP0003252_abnormal_bile_duct2.83206571
10MP0008058_abnormal_DNA_repair2.82918929
11MP0003806_abnormal_nucleotide_metabolis2.81125018
12MP0002102_abnormal_ear_morphology2.68859973
13MP0003880_abnormal_central_pattern2.65418119
14MP0010329_abnormal_lipoprotein_level2.62885980
15MP0006072_abnormal_retinal_apoptosis2.54788226
16MP0001666_abnormal_nutrient_absorption2.53824126
17MP0009697_abnormal_copulation2.48993606
18MP0003890_abnormal_embryonic-extraembry2.33232986
19MP0003121_genomic_imprinting2.29382673
20MP0001984_abnormal_olfaction2.21424590
21MP0003122_maternal_imprinting2.19375882
22MP0009840_abnormal_foam_cell2.11264242
23MP0010094_abnormal_chromosome_stability2.08344989
24MP0005083_abnormal_biliary_tract2.08308527
25MP0003195_calcinosis2.03968054
26MP0005551_abnormal_eye_electrophysiolog1.97229207
27MP0001293_anophthalmia1.95187843
28MP0005332_abnormal_amino_acid1.93144765
29MP0003705_abnormal_hypodermis_morpholog1.86627274
30MP0005253_abnormal_eye_physiology1.85426982
31MP0000609_abnormal_liver_physiology1.84509025
32MP0008438_abnormal_cutaneous_collagen1.83680317
33MP0001529_abnormal_vocalization1.78891613
34MP0003868_abnormal_feces_composition1.77212316
35MP0005319_abnormal_enzyme/_coenzyme1.76940865
36MP0008995_early_reproductive_senescence1.75772825
37MP0006276_abnormal_autonomic_nervous1.70953036
38MP0003718_maternal_effect1.66819233
39MP0008789_abnormal_olfactory_epithelium1.62450499
40MP0002234_abnormal_pharynx_morphology1.62175849
41MP0003191_abnormal_cellular_cholesterol1.61474863
42MP0003436_decreased_susceptibility_to1.58258943
43MP0004019_abnormal_vitamin_homeostasis1.54702186
44MP0002118_abnormal_lipid_homeostasis1.54060716
45MP0010352_gastrointestinal_tract_polyps1.53153237
46MP0010368_abnormal_lymphatic_system1.50887191
47MP0002837_dystrophic_cardiac_calcinosis1.48711832
48MP0003186_abnormal_redox_activity1.48280028
49MP0001835_abnormal_antigen_presentation1.47217621
50MP0005220_abnormal_exocrine_pancreas1.44803481
51MP0003693_abnormal_embryo_hatching1.43865708
52MP0000372_irregular_coat_pigmentation1.43750161
53MP0004133_heterotaxia1.43278460
54MP0003011_delayed_dark_adaptation1.42053459
55MP0000631_abnormal_neuroendocrine_gland1.40836336
56MP0009046_muscle_twitch1.38323990
57MP0000598_abnormal_liver_morphology1.36432507
58MP0005499_abnormal_olfactory_system1.35165627
59MP0005394_taste/olfaction_phenotype1.35165627
60MP0002396_abnormal_hematopoietic_system1.32027057
61MP0000427_abnormal_hair_cycle1.31047574
62MP0003937_abnormal_limbs/digits/tail_de1.30705299
63MP0003567_abnormal_fetal_cardiomyocyte1.30181623
64MP0009764_decreased_sensitivity_to1.29475328
65MP0003119_abnormal_digestive_system1.28810606
66MP0002233_abnormal_nose_morphology1.28792957
67MP0001764_abnormal_homeostasis1.25680094
68MP0009763_increased_sensitivity_to1.24524746
69MP0004215_abnormal_myocardial_fiber1.23239572
70MP0005423_abnormal_somatic_nervous1.22879158
71MP0002751_abnormal_autonomic_nervous1.22433593
72MP0005408_hypopigmentation1.19427633
73MP0002736_abnormal_nociception_after1.17764240
74MP0001968_abnormal_touch/_nociception1.17482784
75MP0000647_abnormal_sebaceous_gland1.17051505
76MP0005187_abnormal_penis_morphology1.15681675
77MP0001486_abnormal_startle_reflex1.15002847
78MP0008469_abnormal_protein_level1.14769611
79MP0005464_abnormal_platelet_physiology1.14466931
80MP0009765_abnormal_xenobiotic_induced1.13931433
81MP0005584_abnormal_enzyme/coenzyme_acti1.13446015
82MP0005645_abnormal_hypothalamus_physiol1.13406789
83MP0001986_abnormal_taste_sensitivity1.13164724
84MP0000343_altered_response_to1.12718053
85MP0004957_abnormal_blastocyst_morpholog1.12330879
86MP0009384_cardiac_valve_regurgitation1.12289507
87MP0001929_abnormal_gametogenesis1.12151827
88MP0002282_abnormal_trachea_morphology1.11151871
89MP0005391_vision/eye_phenotype1.10086044
90MP0002638_abnormal_pupillary_reflex1.09405960
91MP0002933_joint_inflammation1.09247178
92MP0001188_hyperpigmentation1.08888198
93MP0003656_abnormal_erythrocyte_physiolo1.08660454
94MP0008932_abnormal_embryonic_tissue1.07735057
95MP0002138_abnormal_hepatobiliary_system1.07732026
96MP0003111_abnormal_nucleus_morphology1.07632992
97MP0003786_premature_aging1.07576631
98MP0006054_spinal_hemorrhage1.06199697
99MP0002160_abnormal_reproductive_system1.05411449
100MP0003646_muscle_fatigue1.04667708
101MP0000516_abnormal_urinary_system1.04606359
102MP0005367_renal/urinary_system_phenotyp1.04606359
103MP0002210_abnormal_sex_determination1.04481623
104MP0002419_abnormal_innate_immunity1.04316877
105MP0003077_abnormal_cell_cycle1.02670526
106MP0002090_abnormal_vision1.02452852
107MP0001286_abnormal_eye_development1.01825024
108MP0000778_abnormal_nervous_system1.00494473
109MP0000653_abnormal_sex_gland1.00225616
110MP0003698_abnormal_male_reproductive0.99643811
111MP0002272_abnormal_nervous_system0.99415290
112MP0005084_abnormal_gallbladder_morpholo0.98622672
113MP0001485_abnormal_pinna_reflex0.98429449
114MP0005646_abnormal_pituitary_gland0.97472308
115MP0001915_intracranial_hemorrhage0.96646806
116MP0001145_abnormal_male_reproductive0.95810445
117MP0009745_abnormal_behavioral_response0.95633574
118MP0001533_abnormal_skeleton_physiology0.95462236
119MP0003943_abnormal_hepatobiliary_system0.94231308
120MP0004142_abnormal_muscle_tone0.90534143
121MP0000383_abnormal_hair_follicle0.87259506
122MP0005195_abnormal_posterior_eye0.86798472
123MP0009643_abnormal_urine_homeostasis0.86738214
124MP0004264_abnormal_extraembryonic_tissu0.85711578
125MP0005389_reproductive_system_phenotype0.83059924
126MP0002009_preneoplasia0.82651850
127MP0000569_abnormal_digit_pigmentation0.81920819
128MP0005023_abnormal_wound_healing0.81668163
129MP0000049_abnormal_middle_ear0.81478601
130MP0009785_altered_susceptibility_to0.81472676
131MP0002752_abnormal_somatic_nervous0.80825362
132MP0004043_abnormal_pH_regulation0.80561186
133MP0004145_abnormal_muscle_electrophysio0.80251392
134MP0006035_abnormal_mitochondrial_morpho0.80213915
135MP0000465_gastrointestinal_hemorrhage0.80150991
136MP0002928_abnormal_bile_duct0.80036015
137MP0002084_abnormal_developmental_patter0.79390957
138MP0001853_heart_inflammation0.79175335
139MP0002557_abnormal_social/conspecific_i0.78703810
140MP0003724_increased_susceptibility_to0.78171687
141MP0008872_abnormal_physiological_respon0.77737292
142MP0002148_abnormal_hypersensitivity_rea0.76502745
143MP0003279_aneurysm0.75295751
144MP0009642_abnormal_blood_homeostasis0.75105388
145MP0000767_abnormal_smooth_muscle0.74750414
146MP0005386_behavior/neurological_phenoty0.74341265
147MP0004924_abnormal_behavior0.74341265
148MP0003300_gastrointestinal_ulcer0.73319760
149MP0001119_abnormal_female_reproductive0.72648825
150MP0006082_CNS_inflammation0.72286077
151MP0004134_abnormal_chest_morphology0.72089569
152MP0003283_abnormal_digestive_organ0.71624748
153MP0005410_abnormal_fertilization0.70443645
154MP0001324_abnormal_eye_pigmentation0.70094055
155MP0008057_abnormal_DNA_replication0.69849580
156MP0002184_abnormal_innervation0.69780000
157MP0001845_abnormal_inflammatory_respons0.69386291
158MP0005503_abnormal_tendon_morphology0.68630884
159MP0003566_abnormal_cell_adhesion0.68517472
160MP0005025_abnormal_response_to0.67960539
161MP0002938_white_spotting0.67793571
162MP0008873_increased_physiological_sensi0.67300704
163MP0003183_abnormal_peptide_metabolism0.66350414
164MP0002115_abnormal_skeleton_extremities0.65888650
165MP0000685_abnormal_immune_system0.65875670
166MP0005451_abnormal_body_composition0.65742795
167MP0005390_skeleton_phenotype0.64992439
168MP0000249_abnormal_blood_vessel0.64517340
169MP0002971_abnormal_brown_adipose0.64075281
170MP0001542_abnormal_bone_strength0.63880359
171MP0004130_abnormal_muscle_cell0.63877503
172MP0005670_abnormal_white_adipose0.63714781
173MP0004185_abnormal_adipocyte_glucose0.62291810
174MP0005376_homeostasis/metabolism_phenot0.60743172
175MP0005164_abnormal_response_to0.58110034
176MP0009053_abnormal_anal_canal0.57838975
177MP0004147_increased_porphyrin_level0.57113726
178MP0002166_altered_tumor_susceptibility0.57047464
179MP0005275_abnormal_skin_tensile0.56558228
180MP0005636_abnormal_mineral_homeostasis0.56326071
181MP0002896_abnormal_bone_mineralization0.52390651
182MP0002254_reproductive_system_inflammat0.52289685
183MP0002405_respiratory_system_inflammati0.51961015
184MP0008007_abnormal_cellular_replicative0.50255179
185MP0002089_abnormal_postnatal_growth/wei0.50190139
186MP0002060_abnormal_skin_morphology0.50171435
187MP0006036_abnormal_mitochondrial_physio0.49994378

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.55333249
2Deep venous thrombosis (HP:0002625)5.25582873
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.16103153
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.14679032
5Xanthomatosis (HP:0000991)4.86886805
6Prolonged partial thromboplastin time (HP:0003645)4.15026892
7Hyperlipoproteinemia (HP:0010980)4.03521971
8Hypobetalipoproteinemia (HP:0003563)3.96702034
9Complement deficiency (HP:0004431)3.96191757
10Pancreatic cysts (HP:0001737)3.86364205
11Pancreatic fibrosis (HP:0100732)3.82283941
12Abnormality of pyrimidine metabolism (HP:0004353)3.77943893
13Vitreoretinal degeneration (HP:0000655)3.73911387
14Epidermoid cyst (HP:0200040)3.73483248
15Abnormality of the common coagulation pathway (HP:0010990)3.62535551
16Hyperammonemia (HP:0001987)3.56296571
17Abnormality of sulfur amino acid metabolism (HP:0004339)3.38252338
18True hermaphroditism (HP:0010459)3.31911804
19Fat malabsorption (HP:0002630)3.31547157
20Hypolipoproteinemia (HP:0010981)3.30284380
21Abnormality of the labia minora (HP:0012880)3.29799986
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.29017526
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28522671
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.28075258
25Abnormality of the intrinsic pathway (HP:0010989)3.25025671
26Abnormality of methionine metabolism (HP:0010901)3.22348728
27Hypoalphalipoproteinemia (HP:0003233)3.19879963
28Abnormality of midbrain morphology (HP:0002418)3.16061958
29Molar tooth sign on MRI (HP:0002419)3.16061958
30Abnormality of complement system (HP:0005339)3.06754958
31Abnormality of fatty-acid metabolism (HP:0004359)3.03392590
32Joint hemorrhage (HP:0005261)3.02010567
33Hypercholesterolemia (HP:0003124)3.00660638
34Medial flaring of the eyebrow (HP:0010747)2.99965979
35Epiphyseal dysplasia (HP:0002656)2.96197226
36Nephronophthisis (HP:0000090)2.92366908
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.89238047
38Myocardial infarction (HP:0001658)2.88456753
39Steatorrhea (HP:0002570)2.85841313
40Ketosis (HP:0001946)2.81388169
41Abnormality of the renal cortex (HP:0011035)2.78116807
42Hypoglycemic coma (HP:0001325)2.75681925
43Intestinal atresia (HP:0011100)2.73343628
44Abnormal tarsal ossification (HP:0008369)2.72468149
45Congenital primary aphakia (HP:0007707)2.67796265
46Conjugated hyperbilirubinemia (HP:0002908)2.67519597
47Abnormality of the lumbar spine (HP:0100712)2.65913070
48Recurrent gram-negative bacterial infections (HP:0005420)2.64932325
49Gait imbalance (HP:0002141)2.64558962
50Colon cancer (HP:0003003)2.64153188
51Nephrogenic diabetes insipidus (HP:0009806)2.62494601
52Renal cortical cysts (HP:0000803)2.61068875
53Abnormality of the renal medulla (HP:0100957)2.60878122
54Generalized aminoaciduria (HP:0002909)2.60503236
55Genital tract atresia (HP:0001827)2.59427199
56Abnormality of serum amino acid levels (HP:0003112)2.57715052
57Chronic hepatic failure (HP:0100626)2.56437756
58Abnormality of nucleobase metabolism (HP:0010932)2.56226199
59Ependymoma (HP:0002888)2.54660619
60Meckel diverticulum (HP:0002245)2.49925209
61Abnormality of the ileum (HP:0001549)2.49804471
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.49471532
63Systemic lupus erythematosus (HP:0002725)2.46773343
64Hyperglycinemia (HP:0002154)2.45429759
65Abnormality of chromosome stability (HP:0003220)2.45134928
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.44793860
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43182988
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.42047864
69Abnormality of serine family amino acid metabolism (HP:0010894)2.40695718
70Abnormality of glycine metabolism (HP:0010895)2.40695718
71Abnormal foot bone ossification (HP:0010675)2.39714955
72Abnormal biliary tract physiology (HP:0012439)2.39291841
73Bile duct proliferation (HP:0001408)2.39291841
74Enlarged kidneys (HP:0000105)2.38260285
75Vaginal atresia (HP:0000148)2.37696259
76Cystic liver disease (HP:0006706)2.36048291
77Chromsome breakage (HP:0040012)2.31743539
78Syringomyelia (HP:0003396)2.31489086
79Spinal cord lesions (HP:0100561)2.31489086
80Postaxial foot polydactyly (HP:0001830)2.29311403
81Hyperbilirubinemia (HP:0002904)2.28241312
82Ectopia lentis (HP:0001083)2.25899370
83Short tibia (HP:0005736)2.25839556
84Glomerulonephritis (HP:0000099)2.23759007
85Sloping forehead (HP:0000340)2.23234477
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19969309
87Dicarboxylic aciduria (HP:0003215)2.19969309
88Patent foramen ovale (HP:0001655)2.18579231
89Irregular epiphyses (HP:0010582)2.17840528
90Supernumerary spleens (HP:0009799)2.16651611
91Cardiovascular calcification (HP:0011915)2.15808824
92Vascular calcification (HP:0004934)2.15270349
93Abnormality of iron homeostasis (HP:0011031)2.14464937
94Upper motor neuron abnormality (HP:0002127)2.14327760
95Pigmentary retinal degeneration (HP:0001146)2.13717625
96Protrusio acetabuli (HP:0003179)2.13395641
97Preaxial hand polydactyly (HP:0001177)2.13286222
98Delayed CNS myelination (HP:0002188)2.13171412
99Hepatocellular carcinoma (HP:0001402)2.12808347
100Neoplasm of the adrenal cortex (HP:0100641)2.12120550
101Nausea (HP:0002018)2.11871775
102Osteolytic defects of the hand bones (HP:0009699)2.11662162
103Osteolytic defects of the phalanges of the hand (HP:0009771)2.11662162
104Hyperglycinuria (HP:0003108)2.11600443
105Glioma (HP:0009733)2.11501411
106Spontaneous abortion (HP:0005268)2.10502633
107Poor coordination (HP:0002370)2.10273386
108Recurrent bacterial skin infections (HP:0005406)2.09304003
109Dandy-Walker malformation (HP:0001305)2.08904932
110Hypophosphatemic rickets (HP:0004912)2.08850524
111Disproportionate tall stature (HP:0001519)2.08838206
112Astrocytoma (HP:0009592)2.08373602
113Abnormality of the astrocytes (HP:0100707)2.08373602
114Volvulus (HP:0002580)2.07308960
115Opisthotonus (HP:0002179)2.05578081
116Increased mean platelet volume (HP:0011877)2.04669200
117Type II lissencephaly (HP:0007260)2.03789667
118Methylmalonic acidemia (HP:0002912)2.02249677
119Gingival bleeding (HP:0000225)2.02208049
120Abolished electroretinogram (ERG) (HP:0000550)2.00717732
121Sclerocornea (HP:0000647)2.00668859
122Mitral stenosis (HP:0001718)1.99619599
123Myositis (HP:0100614)1.99204982
124Metabolic acidosis (HP:0001942)1.99163834
125Peritonitis (HP:0002586)1.98288551
126Cupped ribs (HP:0000887)1.97799403
127Pancreatic islet-cell hyperplasia (HP:0004510)1.96676122
128Congenital stationary night blindness (HP:0007642)1.95833776
129Abnormality of purine metabolism (HP:0004352)1.95367352
130Periodontitis (HP:0000704)1.95235186
131Postaxial hand polydactyly (HP:0001162)1.94659686
132Spastic diplegia (HP:0001264)1.93939138
133Gaze-evoked nystagmus (HP:0000640)1.93281441
134Attenuation of retinal blood vessels (HP:0007843)1.92724359
135Rhabdomyosarcoma (HP:0002859)1.92251884
136Abnormal gallbladder physiology (HP:0012438)1.91447042
137Cholecystitis (HP:0001082)1.91447042
138Acute encephalopathy (HP:0006846)1.89469514
139Type 2 muscle fiber atrophy (HP:0003554)1.89002626
140Triphalangeal thumb (HP:0001199)1.88348835
141Thrombophlebitis (HP:0004418)1.88111928
142Increased CSF lactate (HP:0002490)1.87781376
143Increased serum ferritin (HP:0003281)1.87662868
144Acute necrotizing encephalopathy (HP:0006965)1.87621621
145Anencephaly (HP:0002323)1.87464180
146Broad-based gait (HP:0002136)1.87443042
147Skin nodule (HP:0200036)1.86526615
148Abnormality of transition element cation homeostasis (HP:0011030)1.86256974
149Gonadotropin excess (HP:0000837)1.83562844
150Abnormality of the duodenum (HP:0002246)1.82966330
151Absent frontal sinuses (HP:0002688)1.82305784
152Stomach cancer (HP:0012126)1.82108183
153Neonatal hypoglycemia (HP:0001998)1.81990676
154Abnormal platelet volume (HP:0011876)1.81682343
155Abnormal gallbladder morphology (HP:0012437)1.81660312
156Protuberant abdomen (HP:0001538)1.81612191
157Progressive macrocephaly (HP:0004481)1.81448123
1583-Methylglutaconic aciduria (HP:0003535)1.80097063
159Abnormal cartilage morphology (HP:0002763)1.79483094
160Medulloblastoma (HP:0002885)1.79041833
161Duodenal stenosis (HP:0100867)1.77335940
162Small intestinal stenosis (HP:0012848)1.77335940
163Gastrointestinal atresia (HP:0002589)1.77082570
164Hepatoblastoma (HP:0002884)1.76710698
165Abnormality of glycolysis (HP:0004366)1.76313426
166Increased serum pyruvate (HP:0003542)1.76313426
167Increased neuronal autofluorescent lipopigment (HP:0002074)1.76011520
168Broad foot (HP:0001769)1.75632467
169Occipital encephalocele (HP:0002085)1.75473343
170Menorrhagia (HP:0000132)1.75404780
171Congenital hepatic fibrosis (HP:0002612)1.75149521
172Metaphyseal dysplasia (HP:0100255)1.75113089
173Tubular atrophy (HP:0000092)1.74723098
174Absent radius (HP:0003974)1.71522819
175Hyperinsulinemic hypoglycemia (HP:0000825)1.71484638
176Abnormal biliary tract morphology (HP:0012440)1.71037326
177Clubbing of toes (HP:0100760)1.70997159
178Abnormality of the preputium (HP:0100587)1.70670244
179Narrow forehead (HP:0000341)1.70475838
180Astigmatism (HP:0000483)1.69717179
181Optic nerve hypoplasia (HP:0000609)1.69647379
182Lissencephaly (HP:0001339)1.68648362
183Mitochondrial inheritance (HP:0001427)1.67695506
184Bifid tongue (HP:0010297)1.66897348
185Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66755158
186Tubulointerstitial nephritis (HP:0001970)1.66568652
187Abnormal lung lobation (HP:0002101)1.66257525
188Biliary tract neoplasm (HP:0100574)1.66015289
189Decreased testicular size (HP:0008734)1.65231041
190Male pseudohermaphroditism (HP:0000037)1.64264648
191Oculomotor apraxia (HP:0000657)1.64011354
192Nephroblastoma (Wilms tumor) (HP:0002667)1.63806545
193Absent forearm bone (HP:0003953)1.63226686
194Aplasia involving forearm bones (HP:0009822)1.63226686
195Thyroiditis (HP:0100646)1.63101905
196Specific learning disability (HP:0001328)1.62945927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT35.40232564
2PKN23.75372056
3BMPR1B3.74017733
4BRD43.45884280
5MAP4K23.25861922
6TRIM283.24871740
7BCKDK3.15647608
8ERN13.12134835
9WNK32.81210642
10KIT2.77592798
11ZAK2.70374510
12MKNK22.58950258
13BCR2.54822538
14STK162.54764988
15TNIK2.39298495
16NEK92.34334771
17TAOK32.28746925
18NUAK12.26053335
19FGFR42.25669168
20MKNK12.22532689
21ACVR1B2.20771749
22SRPK12.13318070
23BLK2.12710229
24CSF1R2.08801821
25MAP3K42.07003051
26ERBB32.05762466
27MAP3K32.03464180
28MAP3K101.93498710
29SIK31.76501089
30SIK11.72891348
31MAP3K141.62390106
32PINK11.61517075
33PLK41.57698485
34TRIB31.54048074
35TBK11.49596305
36MST41.48540243
37CASK1.48083880
38CCNB11.41687221
39PLK31.40683788
40MAPK131.37928786
41IRAK41.32153428
42PLK21.29766683
43CSNK1G11.29465133
44CDC71.29129235
45GRK11.24092701
46TTK1.23572838
47STK31.23221728
48JAK31.23080293
49PBK1.16838464
50FGFR11.13222058
51MAP2K71.13195056
52TGFBR11.11543044
53CDK121.10737943
54CSNK1G31.08556358
55OXSR11.05692059
56EPHA41.04841109
57PAK31.04148031
58CSNK1A1L1.04082173
59MATK1.02115469
60TEC1.01974572
61PLK11.01068673
62BUB10.98657144
63CSNK1G20.98407686
64AKT30.96500320
65STK240.92898616
66PIM20.92455820
67FGFR20.92161720
68DYRK30.91953702
69IRAK30.91386517
70ZAP700.91002813
71IRAK10.87913903
72EPHB10.87856980
73STK390.87503860
74INSRR0.86527204
75TYK20.85530646
76TGFBR20.84161470
77EIF2AK10.84075975
78OBSCN0.83538696
79DDR20.82887389
80WEE10.81637089
81PDK30.80958912
82PDK40.80958912
83TIE10.80928406
84MAP2K30.80759415
85PRKCE0.80675153
86PRPF4B0.79877228
87NME20.79477394
88PTK60.79226129
89FGFR30.78914354
90PDK20.78885577
91DYRK20.77719530
92IKBKE0.76059119
93NEK10.75030734
94MARK10.73136830
95CAMK1D0.72935602
96PIK3CA0.71314095
97LRRK20.70358892
98VRK20.67878601
99ATM0.66972846
100EIF2AK20.66535500
101PRKCG0.66030365
102MAP4K10.64015638
103BRSK20.63587702
104TAOK20.62130327
105MINK10.61612590
106MAP3K130.60295827
107FRK0.58983586
108ATR0.57476052
109DYRK1B0.57362622
110ERBB40.57335561
111MAPK110.56536658
112NTRK20.56535709
113RPS6KA40.56469740
114PASK0.55837280
115PHKG20.55632822
116PHKG10.55632822
117EEF2K0.55016191
118CHEK20.51736436
119KDR0.51326530
120PIK3CG0.51326059
121STK38L0.51016606
122TAF10.50531515
123DYRK1A0.49391283
124STK100.49119391
125EPHA30.49070026
126CDK60.48001769
127CDK30.47977231
128LYN0.47756525
129CDK190.47728472
130EIF2AK30.47321831
131VRK10.46576718
132CSNK1D0.46537171
133TTN0.44344991
134JAK20.44328137
135ADRBK20.43677135
136MOS0.42175454
137CAMK2A0.41937687
138ITK0.41230590
139YES10.41034289
140NTRK30.40184448
141EGFR0.37912439
142FER0.37905052
143MAP2K40.36754060
144BTK0.36650780
145CSNK1A10.36453925
146WNK40.35253419
147PAK40.33977334
148MET0.33950889
149TSSK60.33817479
150PRKACB0.33494393
151PRKAA10.33299112
152AURKB0.33250740
153CHEK10.32954093
154NLK0.32466691
155BRSK10.32429641
156SGK20.31984770
157MUSK0.31333903
158PDK10.30166873
159LATS10.29834897
160IGF1R0.26779983
161CHUK0.26670452
162STK40.26295708
163EPHA20.25575717
164TRPM70.24943905
165MAPK40.23784610
166MAPK30.23509580
167ILK0.23297840
168ERBB20.22842940
169PRKAA20.22676235
170RPS6KB20.21861280

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.00345212
2Caffeine metabolism_Homo sapiens_hsa002323.29681143
3Homologous recombination_Homo sapiens_hsa034402.90908985
4Fatty acid degradation_Homo sapiens_hsa000712.84745251
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.80422600
6Fanconi anemia pathway_Homo sapiens_hsa034602.77388709
7Mismatch repair_Homo sapiens_hsa034302.71929558
8Complement and coagulation cascades_Homo sapiens_hsa046102.66007656
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61553446
10Propanoate metabolism_Homo sapiens_hsa006402.58164913
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50066221
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48009723
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36656323
14Tryptophan metabolism_Homo sapiens_hsa003802.36261087
15Arginine biosynthesis_Homo sapiens_hsa002202.26785308
16Basal transcription factors_Homo sapiens_hsa030222.21753579
17RNA polymerase_Homo sapiens_hsa030202.16871553
18Phototransduction_Homo sapiens_hsa047442.16169861
19Fatty acid metabolism_Homo sapiens_hsa012122.15027180
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08543603
21RNA degradation_Homo sapiens_hsa030181.99347967
22Fatty acid elongation_Homo sapiens_hsa000621.97854484
23Staphylococcus aureus infection_Homo sapiens_hsa051501.93160084
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92410103
25Peroxisome_Homo sapiens_hsa041461.89575700
26PPAR signaling pathway_Homo sapiens_hsa033201.88096265
27Nitrogen metabolism_Homo sapiens_hsa009101.84425138
28Selenocompound metabolism_Homo sapiens_hsa004501.81363075
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80195254
30Chemical carcinogenesis_Homo sapiens_hsa052041.79936767
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76842479
32RNA transport_Homo sapiens_hsa030131.72656454
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70354884
34One carbon pool by folate_Homo sapiens_hsa006701.68746952
35Proteasome_Homo sapiens_hsa030501.68207655
36DNA replication_Homo sapiens_hsa030301.66292538
37Oxidative phosphorylation_Homo sapiens_hsa001901.63903181
38beta-Alanine metabolism_Homo sapiens_hsa004101.62760563
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.60795635
40Base excision repair_Homo sapiens_hsa034101.58493121
41Nucleotide excision repair_Homo sapiens_hsa034201.57750542
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56752841
43Histidine metabolism_Homo sapiens_hsa003401.55909486
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49955347
45Pyruvate metabolism_Homo sapiens_hsa006201.49868768
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48836331
47Biosynthesis of amino acids_Homo sapiens_hsa012301.48111351
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47771084
49Carbon metabolism_Homo sapiens_hsa012001.44780767
50Sulfur metabolism_Homo sapiens_hsa009201.44166249
51Parkinsons disease_Homo sapiens_hsa050121.43486612
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.39490477
53Spliceosome_Homo sapiens_hsa030401.39427662
54Nicotine addiction_Homo sapiens_hsa050331.38523482
55Vitamin digestion and absorption_Homo sapiens_hsa049771.37935344
56Retinol metabolism_Homo sapiens_hsa008301.32732247
57Folate biosynthesis_Homo sapiens_hsa007901.32604347
58Regulation of autophagy_Homo sapiens_hsa041401.31285263
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.31101488
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28970140
61Butanoate metabolism_Homo sapiens_hsa006501.28514215
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.24856791
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23199268
64Lysine degradation_Homo sapiens_hsa003101.22702856
65ABC transporters_Homo sapiens_hsa020101.21844460
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15998073
67Circadian rhythm_Homo sapiens_hsa047101.15126931
68Huntingtons disease_Homo sapiens_hsa050161.13710499
69Fat digestion and absorption_Homo sapiens_hsa049751.13430543
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12782064
71Purine metabolism_Homo sapiens_hsa002301.09390447
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09353308
73Tyrosine metabolism_Homo sapiens_hsa003501.06782784
74mRNA surveillance pathway_Homo sapiens_hsa030151.06320246
75Phenylalanine metabolism_Homo sapiens_hsa003601.03945954
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01329102
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01321240
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99988837
79Pyrimidine metabolism_Homo sapiens_hsa002400.97569945
80Starch and sucrose metabolism_Homo sapiens_hsa005000.92317513
81Oocyte meiosis_Homo sapiens_hsa041140.90899013
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90208979
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89735601
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88609309
85Steroid biosynthesis_Homo sapiens_hsa001000.87751197
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86641150
87Taste transduction_Homo sapiens_hsa047420.83114732
88Olfactory transduction_Homo sapiens_hsa047400.82670714
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82180360
90Bile secretion_Homo sapiens_hsa049760.79224553
91Ether lipid metabolism_Homo sapiens_hsa005650.78399310
92Vitamin B6 metabolism_Homo sapiens_hsa007500.77347751
93Alzheimers disease_Homo sapiens_hsa050100.72465943
94Arginine and proline metabolism_Homo sapiens_hsa003300.71776318
95Legionellosis_Homo sapiens_hsa051340.69308113
96Pentose phosphate pathway_Homo sapiens_hsa000300.67779429
97p53 signaling pathway_Homo sapiens_hsa041150.67280075
98Glutathione metabolism_Homo sapiens_hsa004800.62160692
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.61910065
100GABAergic synapse_Homo sapiens_hsa047270.58031579
101Basal cell carcinoma_Homo sapiens_hsa052170.54479644
102Hedgehog signaling pathway_Homo sapiens_hsa043400.50846109
103Cardiac muscle contraction_Homo sapiens_hsa042600.48515479
104Morphine addiction_Homo sapiens_hsa050320.48442486
105Non-homologous end-joining_Homo sapiens_hsa034500.46006392
106Serotonergic synapse_Homo sapiens_hsa047260.44191066
107Glutamatergic synapse_Homo sapiens_hsa047240.43490497
108Circadian entrainment_Homo sapiens_hsa047130.42548663
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40735160
110Dopaminergic synapse_Homo sapiens_hsa047280.40053678
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39579466
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39109619
113Metabolic pathways_Homo sapiens_hsa011000.38523619
114Wnt signaling pathway_Homo sapiens_hsa043100.37897904
115Collecting duct acid secretion_Homo sapiens_hsa049660.37384189
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36812894
117N-Glycan biosynthesis_Homo sapiens_hsa005100.34857730
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34850648
119TGF-beta signaling pathway_Homo sapiens_hsa043500.34767997
120Malaria_Homo sapiens_hsa051440.33924397
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33482382
122Sulfur relay system_Homo sapiens_hsa041220.33412122
123Hippo signaling pathway_Homo sapiens_hsa043900.32101852
124Protein export_Homo sapiens_hsa030600.30646157
125Leishmaniasis_Homo sapiens_hsa051400.27737277
126Herpes simplex infection_Homo sapiens_hsa051680.26638237
127Phagosome_Homo sapiens_hsa041450.26356945
128Glycerolipid metabolism_Homo sapiens_hsa005610.26313462
129Bladder cancer_Homo sapiens_hsa052190.22778369
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22439210
131Protein digestion and absorption_Homo sapiens_hsa049740.22137525
132Small cell lung cancer_Homo sapiens_hsa052220.20477336
133Lysosome_Homo sapiens_hsa041420.19471582
134Influenza A_Homo sapiens_hsa051640.19438809
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19031351
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.18791517
137Insulin resistance_Homo sapiens_hsa049310.18558368
138Cell cycle_Homo sapiens_hsa041100.17875428
139Fatty acid biosynthesis_Homo sapiens_hsa000610.17039270
140ECM-receptor interaction_Homo sapiens_hsa045120.15970454
141Hepatitis B_Homo sapiens_hsa051610.13212983
142Toxoplasmosis_Homo sapiens_hsa051450.12819840
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12665009
144Renin-angiotensin system_Homo sapiens_hsa046140.12268927
145Pertussis_Homo sapiens_hsa051330.11958792
146Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.09974756
147Linoleic acid metabolism_Homo sapiens_hsa005910.09243725
148Pancreatic cancer_Homo sapiens_hsa052120.08547536
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.06020862
150Measles_Homo sapiens_hsa051620.05728706
151Glucagon signaling pathway_Homo sapiens_hsa049220.05695465
152NF-kappa B signaling pathway_Homo sapiens_hsa040640.05330792

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