NR2C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.16879486
2regulation of histone H3-K27 methylation (GO:0061085)4.55210319
3nuclear pore organization (GO:0006999)4.29239792
4locomotory exploration behavior (GO:0035641)4.09859733
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.01836009
6negative regulation of translation, ncRNA-mediated (GO:0040033)4.01836009
7regulation of translation, ncRNA-mediated (GO:0045974)4.01836009
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.93639128
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.85569615
10phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.85507614
11regulation of RNA export from nucleus (GO:0046831)3.77339436
12pore complex assembly (GO:0046931)3.59723279
13histone lysine demethylation (GO:0070076)3.57899961
14histone H3-K36 demethylation (GO:0070544)3.46009510
15cellular response to ethanol (GO:0071361)3.45977013
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.41698605
17negative regulation of erythrocyte differentiation (GO:0045647)3.41406941
18histone demethylation (GO:0016577)3.37404274
19regulation of NFAT protein import into nucleus (GO:0051532)3.36265450
20monoubiquitinated protein deubiquitination (GO:0035520)3.33407788
21regulation of nucleobase-containing compound transport (GO:0032239)3.32055392
22regulation of glutamate receptor signaling pathway (GO:1900449)3.30703547
23histone H3-K4 methylation (GO:0051568)3.29219787
24cytoplasmic mRNA processing body assembly (GO:0033962)3.24528886
25vocalization behavior (GO:0071625)3.23831773
26histone H3-K4 trimethylation (GO:0080182)3.21498503
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.20234099
28dendritic spine morphogenesis (GO:0060997)3.15007457
29cerebellar Purkinje cell differentiation (GO:0021702)3.13271304
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.10922021
31synaptic vesicle maturation (GO:0016188)3.10486127
32positive regulation of gamma-delta T cell activation (GO:0046645)3.09288495
33embryonic process involved in female pregnancy (GO:0060136)3.01272817
34negative regulation of histone methylation (GO:0031061)2.99703978
35histone lysine methylation (GO:0034968)2.99239182
36regulation of synaptic vesicle exocytosis (GO:2000300)2.95969585
37regulation of gamma-delta T cell differentiation (GO:0045586)2.95601016
38exploration behavior (GO:0035640)2.91743516
39glucocorticoid receptor signaling pathway (GO:0042921)2.91175882
40positive regulation of granulocyte differentiation (GO:0030854)2.89368171
41protein dealkylation (GO:0008214)2.87829300
42protein demethylation (GO:0006482)2.87829300
43glutamate receptor signaling pathway (GO:0007215)2.87380481
44positive regulation of respiratory burst (GO:0060267)2.86156386
45protein localization to synapse (GO:0035418)2.86027721
46positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.84306538
47regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.84306538
48negative regulation of myotube differentiation (GO:0010832)2.83937863
49insulin-like growth factor receptor signaling pathway (GO:0048009)2.81212867
50cilium or flagellum-dependent cell motility (GO:0001539)2.80787604
51embryonic camera-type eye morphogenesis (GO:0048596)2.79427816
52central nervous system projection neuron axonogenesis (GO:0021952)2.78241197
53synaptic transmission, glutamatergic (GO:0035249)2.78197326
54positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.77010546
55regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.77010546
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.76580243
57regulation of germinal center formation (GO:0002634)2.76504528
58lipid translocation (GO:0034204)2.75461749
59phospholipid translocation (GO:0045332)2.75461749
60corticosteroid receptor signaling pathway (GO:0031958)2.75420452
61regulation of long-term neuronal synaptic plasticity (GO:0048169)2.75283697
62synaptic vesicle docking involved in exocytosis (GO:0016081)2.74866696
63B cell receptor signaling pathway (GO:0050853)2.74764811
64dosage compensation (GO:0007549)2.74695126
65regulation of DNA endoreduplication (GO:0032875)2.73904459
66synaptic vesicle exocytosis (GO:0016079)2.73845931
67definitive hemopoiesis (GO:0060216)2.73014585
68coronary vasculature morphogenesis (GO:0060977)2.66538044
69long-term memory (GO:0007616)2.66085480
70protein K11-linked deubiquitination (GO:0035871)2.66057682
71negative regulation of neurotransmitter secretion (GO:0046929)2.63507525
72retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63435697
73neuron cell-cell adhesion (GO:0007158)2.63178892
74neuron-neuron synaptic transmission (GO:0007270)2.63084771
75positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.61517088
76negative regulation of DNA repair (GO:0045738)2.60915697
77regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60206531
78regulation of gamma-delta T cell activation (GO:0046643)2.59020359
79histone H4-K16 acetylation (GO:0043984)2.58088586
80regulation of neuronal synaptic plasticity (GO:0048168)2.57499130
81pre-miRNA processing (GO:0031054)2.57250614
82cAMP catabolic process (GO:0006198)2.56849553
83negative regulation of cell killing (GO:0031342)2.56766713
84negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.56766713
85regulation of synaptic vesicle transport (GO:1902803)2.56528010
86negative regulation of synaptic transmission, GABAergic (GO:0032229)2.55337174
87synaptic vesicle endocytosis (GO:0048488)2.54950503
88positive regulation of Rap GTPase activity (GO:0032854)2.54616333
89glutamate secretion (GO:0014047)2.54478222
90response to epidermal growth factor (GO:0070849)2.54177970
91mitotic sister chromatid cohesion (GO:0007064)2.53667719
92nucleus localization (GO:0051647)2.52988161
93positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52942778
94mechanosensory behavior (GO:0007638)2.52723797
95histone H3-K9 modification (GO:0061647)2.52655192
96peptidyl-threonine phosphorylation (GO:0018107)2.51857811
97regulation of ARF protein signal transduction (GO:0032012)2.51360275
98nerve growth factor signaling pathway (GO:0038180)2.48577435
99axonal fasciculation (GO:0007413)2.47809727
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47777151
101transmission of nerve impulse (GO:0019226)2.47199095
102dendrite morphogenesis (GO:0048813)2.46951640
103regulation of B cell receptor signaling pathway (GO:0050855)2.46633287
104layer formation in cerebral cortex (GO:0021819)2.46462148
105protein K48-linked deubiquitination (GO:0071108)2.46361137
106regulation of postsynaptic membrane potential (GO:0060078)2.46106815
107positive thymic T cell selection (GO:0045059)2.45617676
108negative thymic T cell selection (GO:0045060)2.43548325
109regulation of histone methylation (GO:0031060)2.43529277
110auditory behavior (GO:0031223)2.43505158
111histone methylation (GO:0016571)2.43270196
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41310867
113V(D)J recombination (GO:0033151)2.40873066
114peptidyl-lysine methylation (GO:0018022)2.40062578
115Golgi to endosome transport (GO:0006895)2.39652570
116neuron recognition (GO:0008038)2.39484900
117regulation of dendritic spine morphogenesis (GO:0061001)2.38938721
118startle response (GO:0001964)2.38588568
119cyclic nucleotide catabolic process (GO:0009214)2.38162077
120histone H3-K9 demethylation (GO:0033169)2.38075825
121protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.37296135
122peptidyl-serine phosphorylation (GO:0018105)2.36694659
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.36497221
124peptidyl-lysine trimethylation (GO:0018023)2.36235891
125regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35281028
126long-term synaptic potentiation (GO:0060291)2.35209587
127L-amino acid import (GO:0043092)2.34909363
128regulation of Rap GTPase activity (GO:0032317)2.34005093
129regulation of histone H3-K4 methylation (GO:0051569)2.33877440
130regulation of ARF GTPase activity (GO:0032312)2.32184057
131positive T cell selection (GO:0043368)2.31829480
132peptidyl-threonine modification (GO:0018210)2.31436967
133establishment of nucleus localization (GO:0040023)2.31349851
134positive regulation of CREB transcription factor activity (GO:0032793)2.30716723
135regulation of neurotransmitter secretion (GO:0046928)2.30411986
136regulation of pigment cell differentiation (GO:0050932)2.30365014
137negative regulation of histone modification (GO:0031057)2.29912711
138piRNA metabolic process (GO:0034587)2.29740741
139protein targeting to Golgi (GO:0000042)2.29653942
140establishment of protein localization to Golgi (GO:0072600)2.29174215
141neural tube formation (GO:0001841)2.28249467
142positive regulation of mRNA catabolic process (GO:0061014)2.27869319
143neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.27634533
144neurotransmitter secretion (GO:0007269)2.26948569
145G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.26661435
146positive regulation of gene expression, epigenetic (GO:0045815)2.26448235
147histone deubiquitination (GO:0016578)2.25042053
148neurotransmitter-gated ion channel clustering (GO:0072578)2.24237568
149microtubule depolymerization (GO:0007019)2.22964867
150negative T cell selection (GO:0043383)2.22684550
151visual learning (GO:0008542)2.22571404
152regulation of synaptic transmission, glutamatergic (GO:0051966)2.21759924
153proline transport (GO:0015824)2.21608214
154regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.21288292
155T cell selection (GO:0045058)2.21050615
156positive regulation of membrane potential (GO:0045838)2.20965378
157positive regulation of dendritic spine morphogenesis (GO:0061003)2.20586651
158central nervous system neuron axonogenesis (GO:0021955)2.20544574
159interkinetic nuclear migration (GO:0022027)2.20430274
160thymic T cell selection (GO:0045061)2.20153464
161negative regulation of dendrite development (GO:2000171)2.19523492
162negative regulation of gene expression, epigenetic (GO:0045814)2.19499199
163antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.19048787
164embryonic eye morphogenesis (GO:0048048)2.18854533
165response to interleukin-15 (GO:0070672)2.17937282
166phosphatidylinositol dephosphorylation (GO:0046856)2.17359928
167positive regulation of synaptic transmission, GABAergic (GO:0032230)2.17113402
168phosphatidylinositol phosphorylation (GO:0046854)2.16651161
169histone H4 deacetylation (GO:0070933)2.16326568
170mannose metabolic process (GO:0006013)2.15938952
171stress granule assembly (GO:0034063)2.15391122
172positive regulation of developmental pigmentation (GO:0048087)2.15141560
173negative regulation of dendrite morphogenesis (GO:0050774)2.14712957
174regulation of protein polyubiquitination (GO:1902914)2.14663856
175negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.14333062
176calcium ion-dependent exocytosis (GO:0017156)2.14265907
177NLS-bearing protein import into nucleus (GO:0006607)2.13956438
178regulation of synaptic plasticity (GO:0048167)2.13625627
179histone H3-K9 methylation (GO:0051567)2.11907041
180nucleus organization (GO:0006997)2.11302991
181peptidyl-serine modification (GO:0018209)2.10869046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.99139789
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.98807863
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.61593091
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.46509811
5GBX2_23144817_ChIP-Seq_PC3_Human3.08449272
6MYC_22102868_ChIP-Seq_BL_Human2.48833651
7AR_21572438_ChIP-Seq_LNCaP_Human2.39759437
8E2F7_22180533_ChIP-Seq_HELA_Human2.28773158
9TCF7_22412390_ChIP-Seq_EML_Mouse2.25124792
10* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.24752468
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15615626
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.13199248
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05615631
14SCL_19346495_ChIP-Seq_HPC-7_Human2.03918796
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00044303
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99443303
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98052290
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96054138
19DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.94925388
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93673288
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93294859
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90426297
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89093744
24DROSHA_22980978_ChIP-Seq_HELA_Human1.87448148
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87097997
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86308809
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79846502
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79584213
29SMAD4_21799915_ChIP-Seq_A2780_Human1.79116509
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77815380
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.74040279
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71943527
33KDM2B_26808549_Chip-Seq_DND41_Human1.69474145
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68456086
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.68174151
36GATA1_22025678_ChIP-Seq_K562_Human1.65773760
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64824118
38TP53_16413492_ChIP-PET_HCT116_Human1.64774999
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61415215
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61415215
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.61380644
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60788678
43REST_21632747_ChIP-Seq_MESCs_Mouse1.58117131
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.54076595
45* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53941049
46P300_19829295_ChIP-Seq_ESCs_Human1.53336308
47STAT3_23295773_ChIP-Seq_U87_Human1.53078654
48PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52732813
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52534275
50TCF4_23295773_ChIP-Seq_U87_Human1.52182145
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50864900
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49313587
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48763329
54GATA1_19941826_ChIP-Seq_K562_Human1.47997566
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46984628
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46888744
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45411079
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.43766261
59MYB_26560356_Chip-Seq_TH1_Human1.42438585
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42377005
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42030395
62SPI1_23127762_ChIP-Seq_K562_Human1.41831041
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41133784
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40869151
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40869151
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40808963
67TAF15_26573619_Chip-Seq_HEK293_Human1.38301744
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.37386087
69* RARB_27405468_Chip-Seq_BRAIN_Mouse1.36472319
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.36440148
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35854284
72MYB_26560356_Chip-Seq_TH2_Human1.35728908
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35273272
74MAF_26560356_Chip-Seq_TH1_Human1.34961003
75VDR_21846776_ChIP-Seq_THP-1_Human1.34575969
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.34495525
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.34327418
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.33343878
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33133444
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33056714
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.32646227
82FUS_26573619_Chip-Seq_HEK293_Human1.32406768
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32225705
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31894438
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31186516
86AR_25329375_ChIP-Seq_VCAP_Human1.31036742
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.30936776
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30725711
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30564871
90GATA2_19941826_ChIP-Seq_K562_Human1.29940234
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.29848303
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29329404
93IGF1R_20145208_ChIP-Seq_DFB_Human1.28621810
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28490331
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27749616
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27098664
97FOXO3_23340844_ChIP-Seq_DLD1_Human1.26595568
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26442179
99* KDM2B_26808549_Chip-Seq_K562_Human1.26310050
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25544244
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25518524
102JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25198692
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24315480
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22961603
105GATA1_19941827_ChIP-Seq_MEL_Mouse1.22672502
106FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22340695
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21915426
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.21759192
109AHR_22903824_ChIP-Seq_MCF-7_Human1.21747308
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21594312
111* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20580101
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20419995
113RUNX2_22187159_ChIP-Seq_PCA_Human1.20076110
114* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19937469
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19882081
116VDR_24763502_ChIP-Seq_THP-1_Human1.19505872
117WT1_19549856_ChIP-ChIP_CCG9911_Human1.19257997
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.18488597
119BCAT_22108803_ChIP-Seq_LS180_Human1.18406988
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18354598
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17688915
122EED_16625203_ChIP-ChIP_MESCs_Mouse1.17431704
123EWS_26573619_Chip-Seq_HEK293_Human1.16965169
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.16179070
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15374432
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14407400
127* RUNX1_27514584_Chip-Seq_MCF-7_Human1.14070691
128* ER_23166858_ChIP-Seq_MCF-7_Human1.13736684
129AR_19668381_ChIP-Seq_PC3_Human1.13359888
130CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13172980
131P53_22387025_ChIP-Seq_ESCs_Mouse1.12795531
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12243731
133VDR_24787735_ChIP-Seq_THP-1_Human1.11891391
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11540435
135CMYC_18555785_Chip-Seq_ESCs_Mouse1.11382503
136PIAS1_25552417_ChIP-Seq_VCAP_Human1.11120524
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10218633
138TCF4_18268006_ChIP-ChIP_LS174T_Human1.10214722
139UTX_26944678_Chip-Seq_JUKART_Human1.09403434
140RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09215125
141EZH2_27294783_Chip-Seq_ESCs_Mouse1.08820616
142SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08595466
143EZH2_27294783_Chip-Seq_NPCs_Mouse1.08025371
144YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07508732
145Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06614881
146NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06257262
147RUNX_20019798_ChIP-Seq_JUKART_Human1.06056587
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05908808
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04815325
150SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04687576
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04291110
152CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02911424
153CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02449087
154GATA2_21666600_ChIP-Seq_HMVEC_Human1.02094990
155* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02062117
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01681568
157P300_18555785_Chip-Seq_ESCs_Mouse1.01656217
158P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00768878
159CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00472483
160RNF2_27304074_Chip-Seq_NSC_Mouse0.99896113
161STAT3_18555785_Chip-Seq_ESCs_Mouse0.99419417
162WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99087324
163E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98731366
164GATA3_27048872_Chip-Seq_THYMUS_Human0.98032874
165ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97477787
166* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96185392
167RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95645136
168* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94410648
169ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94167778
170SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92882412
171IRF8_27001747_Chip-Seq_BMDM_Mouse0.90458587
172ISL1_27105846_Chip-Seq_CPCs_Mouse0.87725720
173CIITA_25753668_ChIP-Seq_RAJI_Human0.87466443
174SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85476921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.45908644
2MP0005409_darkened_coat_color3.80445774
3MP0000569_abnormal_digit_pigmentation3.54333272
4MP0003635_abnormal_synaptic_transmissio2.88384362
5MP0003787_abnormal_imprinting2.85004334
6MP0009046_muscle_twitch2.79625044
7MP0010352_gastrointestinal_tract_polyps2.73782960
8MP0005076_abnormal_cell_differentiation2.72946813
9MP0003705_abnormal_hypodermis_morpholog2.63506054
10MP0000015_abnormal_ear_pigmentation2.51727214
11MP0005646_abnormal_pituitary_gland2.51574876
12MP0009780_abnormal_chondrocyte_physiolo2.41587410
13MP0002063_abnormal_learning/memory/cond2.31794104
14MP0001188_hyperpigmentation2.31458657
15MP0005451_abnormal_body_composition2.29353605
16MP0009745_abnormal_behavioral_response2.27530859
17MP0006292_abnormal_olfactory_placode2.25212805
18MP0005174_abnormal_tail_pigmentation2.16711249
19MP0005423_abnormal_somatic_nervous2.09931626
20MP0005645_abnormal_hypothalamus_physiol2.08828715
21MP0003091_abnormal_cell_migration2.07616964
22MP0009278_abnormal_bone_marrow1.96477001
23MP0003300_gastrointestinal_ulcer1.94764413
24MP0003880_abnormal_central_pattern1.93540723
25MP0004130_abnormal_muscle_cell1.92804029
26MP0002064_seizures1.90676242
27MP0002572_abnormal_emotion/affect_behav1.90209566
28MP0001486_abnormal_startle_reflex1.90062372
29MP0004270_analgesia1.88928864
30MP0002009_preneoplasia1.88715751
31MP0004381_abnormal_hair_follicle1.72541822
32MP0008877_abnormal_DNA_methylation1.67577967
33MP0008569_lethality_at_weaning1.66339026
34MP0004185_abnormal_adipocyte_glucose1.59806713
35MP0002095_abnormal_skin_pigmentation1.55263479
36MP0002735_abnormal_chemical_nociception1.54193007
37MP0000778_abnormal_nervous_system1.53219029
38MP0003172_abnormal_lysosome_physiology1.50561575
39MP0001968_abnormal_touch/_nociception1.49303658
40MP0002272_abnormal_nervous_system1.45979450
41MP0004233_abnormal_muscle_weight1.38207925
42MP0002734_abnormal_mechanical_nocicepti1.35739143
43MP0002557_abnormal_social/conspecific_i1.35201660
44MP0001501_abnormal_sleep_pattern1.34043470
45MP0002166_altered_tumor_susceptibility1.33381199
46MP0002184_abnormal_innervation1.31869437
47MP0004808_abnormal_hematopoietic_stem1.31754324
48MP0002067_abnormal_sensory_capabilities1.30813574
49MP0008057_abnormal_DNA_replication1.30251292
50MP0002102_abnormal_ear_morphology1.29441114
51MP0002822_catalepsy1.28378050
52MP0004811_abnormal_neuron_physiology1.27875348
53MP0005397_hematopoietic_system_phenotyp1.26991011
54MP0001545_abnormal_hematopoietic_system1.26991011
55MP0005666_abnormal_adipose_tissue1.23988872
56MP0003566_abnormal_cell_adhesion1.23920060
57MP0003656_abnormal_erythrocyte_physiolo1.23804636
58MP0001915_intracranial_hemorrhage1.23241979
59MP0001177_atelectasis1.22631304
60MP0003984_embryonic_growth_retardation1.20495219
61MP0005503_abnormal_tendon_morphology1.19612514
62MP0000631_abnormal_neuroendocrine_gland1.19101449
63MP0002088_abnormal_embryonic_growth/wei1.16888682
64MP0005386_behavior/neurological_phenoty1.16459968
65MP0004924_abnormal_behavior1.16459968
66MP0002086_abnormal_extraembryonic_tissu1.16108676
67MP0003763_abnormal_thymus_physiology1.14725904
68MP0000733_abnormal_muscle_development1.12404685
69MP0002396_abnormal_hematopoietic_system1.12133380
70MP0004947_skin_inflammation1.11288519
71MP0003879_abnormal_hair_cell1.11012456
72MP0005621_abnormal_cell_physiology1.10829224
73MP0001984_abnormal_olfaction1.10420141
74MP0009115_abnormal_fat_cell1.09820946
75MP0002876_abnormal_thyroid_physiology1.09436608
76MP0001835_abnormal_antigen_presentation1.08353369
77MP0003121_genomic_imprinting1.07298761
78MP0000003_abnormal_adipose_tissue1.06440562
79MP0001440_abnormal_grooming_behavior1.05558947
80MP0005671_abnormal_response_to1.05474430
81MP0002006_tumorigenesis1.04857552
82MP0005375_adipose_tissue_phenotype1.04177672
83MP0010630_abnormal_cardiac_muscle1.03593609
84MP0003828_pulmonary_edema1.03195680
85MP0006138_congestive_heart_failure1.02377350
86MP0004036_abnormal_muscle_relaxation1.02209872
87MP0004264_abnormal_extraembryonic_tissu1.01263127
88MP0008961_abnormal_basal_metabolism1.00424467
89MP0002925_abnormal_cardiovascular_devel0.99041986
90MP0001672_abnormal_embryogenesis/_devel0.98615934
91MP0005380_embryogenesis_phenotype0.98615934
92MP0005171_absent_coat_pigmentation0.98171576
93MP0004084_abnormal_cardiac_muscle0.97401926
94MP0001851_eye_inflammation0.95941003
95MP0000703_abnormal_thymus_morphology0.95921282
96MP0003690_abnormal_glial_cell0.95644992
97MP0002877_abnormal_melanocyte_morpholog0.95554739
98MP0000955_abnormal_spinal_cord0.95465292
99MP0001348_abnormal_lacrimal_gland0.94876554
100MP0004510_myositis0.93948637
101MP0010094_abnormal_chromosome_stability0.93096298
102MP0002152_abnormal_brain_morphology0.92874618
103MP0004885_abnormal_endolymph0.92422905
104MP0003221_abnormal_cardiomyocyte_apopto0.92230004
105MP0003183_abnormal_peptide_metabolism0.91914880
106MP0004197_abnormal_fetal_growth/weight/0.91683432
107MP0000350_abnormal_cell_proliferation0.91678148
108MP0002722_abnormal_immune_system0.91330924
109MP0003890_abnormal_embryonic-extraembry0.90770789
110MP0002733_abnormal_thermal_nociception0.90453497
111MP0001800_abnormal_humoral_immune0.90240454
112MP0001502_abnormal_circadian_rhythm0.89733272
113MP0000516_abnormal_urinary_system0.88569494
114MP0005367_renal/urinary_system_phenotyp0.88569494
115MP0002882_abnormal_neuron_morphology0.88487650
116MP0002075_abnormal_coat/hair_pigmentati0.88432901
117MP0003045_fibrosis0.87527266
118MP0003077_abnormal_cell_cycle0.87062746
119MP0001873_stomach_inflammation0.86200716
120MP0003115_abnormal_respiratory_system0.85815568
121MP0005394_taste/olfaction_phenotype0.85329388
122MP0005499_abnormal_olfactory_system0.85329388
123MP0001849_ear_inflammation0.84645587
124MP0001970_abnormal_pain_threshold0.83944461
125MP0000371_diluted_coat_color0.82989298
126MP0003303_peritoneal_inflammation0.80944711
127MP0003866_abnormal_defecation0.79526228
128MP0008260_abnormal_autophagy0.77579169
129MP0002168_other_aberrant_phenotype0.77131509
130MP0004134_abnormal_chest_morphology0.76565971
131MP0005310_abnormal_salivary_gland0.75924276
132MP0002177_abnormal_outer_ear0.74962471
133MP0000716_abnormal_immune_system0.74445078
134MP0010678_abnormal_skin_adnexa0.73937753
135MP0004484_altered_response_of0.73818106
136MP0002066_abnormal_motor_capabilities/c0.71605558
137MP0000681_abnormal_thyroid_gland0.70856219
138MP0002398_abnormal_bone_marrow0.70467376
139* MP0003698_abnormal_male_reproductive0.70308586
140MP0009703_decreased_birth_body0.69955605
141MP0001186_pigmentation_phenotype0.69858719
142MP0005551_abnormal_eye_electrophysiolog0.69402973
143MP0003861_abnormal_nervous_system0.69286880
144MP0001299_abnormal_eye_distance/0.69279815
145MP0000383_abnormal_hair_follicle0.69194670
146MP0000689_abnormal_spleen_morphology0.68927355
147MP0004742_abnormal_vestibular_system0.68732516
148MP0001730_embryonic_growth_arrest0.68619106
149MP0001784_abnormal_fluid_regulation0.68408896
150MP0003943_abnormal_hepatobiliary_system0.67951938
151MP0010307_abnormal_tumor_latency0.67566788
152MP0003111_abnormal_nucleus_morphology0.66815443
153MP0003631_nervous_system_phenotype0.66630214
154MP0002998_abnormal_bone_remodeling0.65560583
155MP0002405_respiratory_system_inflammati0.65502884
156MP0000266_abnormal_heart_morphology0.65324726
157MP0004087_abnormal_muscle_fiber0.65165282
158MP0001697_abnormal_embryo_size0.64638695
159MP0000428_abnormal_craniofacial_morphol0.64378161
160MP0003632_abnormal_nervous_system0.64284791
161MP0003633_abnormal_nervous_system0.63911086
162MP0001879_abnormal_lymphatic_vessel0.63755168
163MP0001963_abnormal_hearing_physiology0.63469122
164MP0010234_abnormal_vibrissa_follicle0.63084648
165MP0002249_abnormal_larynx_morphology0.61804689
166MP0001958_emphysema0.61689378
167MP0003935_abnormal_craniofacial_develop0.61236029
168MP0002736_abnormal_nociception_after0.58676250
169MP0003122_maternal_imprinting0.55838486
170MP0004147_increased_porphyrin_level0.55600983
171MP0002928_abnormal_bile_duct0.55558570

Predicted human phenotypes

RankGene SetZ-score
1Elfin facies (HP:0004428)4.62957289
2Renovascular hypertension (HP:0100817)3.81097938
3Hyperacusis (HP:0010780)3.80195837
4Overriding aorta (HP:0002623)3.38773687
5Focal motor seizures (HP:0011153)3.24819914
6Insomnia (HP:0100785)3.21827630
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.15874319
8Absent/shortened dynein arms (HP:0200106)3.15874319
9Flat cornea (HP:0007720)3.11864543
10Febrile seizures (HP:0002373)3.07643688
11Progressive cerebellar ataxia (HP:0002073)3.05936280
12Renal duplication (HP:0000075)2.97264093
13Absent frontal sinuses (HP:0002688)2.86265110
14Genetic anticipation (HP:0003743)2.85347851
15Abnormality of the fingertips (HP:0001211)2.74917436
16Gaze-evoked nystagmus (HP:0000640)2.71221042
17Impaired smooth pursuit (HP:0007772)2.56512485
18Truncal ataxia (HP:0002078)2.55408005
19Obsessive-compulsive behavior (HP:0000722)2.54810518
20Chronic hepatic failure (HP:0100626)2.54224555
21Focal seizures (HP:0007359)2.52710558
22Hypoplasia of the thymus (HP:0000778)2.52449591
23Abnormality of the diencephalon (HP:0010662)2.51141251
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50499405
25Neonatal hypoglycemia (HP:0001998)2.50231057
26Increased nuchal translucency (HP:0010880)2.49822041
27T lymphocytopenia (HP:0005403)2.45812407
28Broad face (HP:0000283)2.43532706
29Toxemia of pregnancy (HP:0100603)2.43240086
30Subacute progressive viral hepatitis (HP:0006572)2.42140465
31Sandal gap (HP:0001852)2.41467337
32Abnormality of ocular smooth pursuit (HP:0000617)2.30617250
33Long eyelashes (HP:0000527)2.29351580
34Subaortic stenosis (HP:0001682)2.29270098
35Abnormality of the left ventricular outflow tract (HP:0011103)2.29270098
36Dislocated radial head (HP:0003083)2.28589346
37Colitis (HP:0002583)2.26488911
38Epileptic encephalopathy (HP:0200134)2.25472504
39Volvulus (HP:0002580)2.25075273
40Deep philtrum (HP:0002002)2.24117800
41Protruding tongue (HP:0010808)2.23107474
42Obstructive sleep apnea (HP:0002870)2.21959640
43Chronic otitis media (HP:0000389)2.21163343
44Macroorchidism (HP:0000053)2.21038958
45Abnormality of the nasal septum (HP:0000419)2.17520070
46Germ cell neoplasia (HP:0100728)2.15886150
47Broad-based gait (HP:0002136)2.14330820
48Pointed chin (HP:0000307)2.13441318
49Urinary bladder sphincter dysfunction (HP:0002839)2.13152201
50Chronic sinusitis (HP:0011109)2.11508901
51Drooling (HP:0002307)2.10677133
52Excessive salivation (HP:0003781)2.10677133
53Sensory axonal neuropathy (HP:0003390)2.09504116
54Spinal cord lesions (HP:0100561)2.09316704
55Syringomyelia (HP:0003396)2.09316704
56Vertebral arch anomaly (HP:0008438)2.08573570
57Bowel diverticulosis (HP:0005222)2.08214436
58Abnormality of the radial head (HP:0003995)2.07843082
59Relative macrocephaly (HP:0004482)2.05577588
60Short 4th metacarpal (HP:0010044)2.04032405
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04032405
62Papilledema (HP:0001085)2.03889318
63Prominent nose (HP:0000448)2.02284279
64Abnormal respiratory motile cilium morphology (HP:0005938)2.02032659
65Abnormal respiratory epithelium morphology (HP:0012253)2.02032659
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01855738
67Abnormality of T cell number (HP:0011839)2.01139390
68Atonic seizures (HP:0010819)2.00906614
69Urethral obstruction (HP:0000796)1.99788356
70Aqueductal stenosis (HP:0002410)1.98162137
71Abnormality of the carotid arteries (HP:0005344)1.97457036
72Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97006243
73Asymmetry of the thorax (HP:0001555)1.95808101
74Abnormality of the distal phalanx of the thumb (HP:0009617)1.95164690
75Enlarged penis (HP:0000040)1.93932719
76Papillary thyroid carcinoma (HP:0002895)1.92978246
77Overgrowth (HP:0001548)1.92546689
78Abnormal hair whorl (HP:0010721)1.92411660
79Cubitus valgus (HP:0002967)1.92103245
80Viral hepatitis (HP:0006562)1.89914258
81Generalized hypopigmentation of hair (HP:0011358)1.89772992
82Microglossia (HP:0000171)1.86482545
83Acute lymphatic leukemia (HP:0006721)1.84521304
84Scanning speech (HP:0002168)1.83636993
85Dysmetric saccades (HP:0000641)1.83609451
86Action tremor (HP:0002345)1.83589146
87Recurrent viral infections (HP:0004429)1.80881268
88Slow saccadic eye movements (HP:0000514)1.80569436
89Bowel incontinence (HP:0002607)1.79701213
90Abnormality of the frontal sinuses (HP:0002687)1.79435086
91Widely spaced teeth (HP:0000687)1.79250769
92Broad palm (HP:0001169)1.78904212
93Abnormal respiratory motile cilium physiology (HP:0012261)1.78547418
94Curly hair (HP:0002212)1.78286258
95Spontaneous hematomas (HP:0007420)1.78098280
96Mitral valve prolapse (HP:0001634)1.77771143
97Cerebral aneurysm (HP:0004944)1.77191423
98Severe combined immunodeficiency (HP:0004430)1.77055055
99Bladder diverticulum (HP:0000015)1.76865778
100Low anterior hairline (HP:0000294)1.75764546
101Neoplasm of the adrenal cortex (HP:0100641)1.74927730
102Narrow palate (HP:0000189)1.74536124
103Tapered finger (HP:0001182)1.74306961
104Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.74295878
105Persistence of primary teeth (HP:0006335)1.74048953
106Hyperkalemia (HP:0002153)1.73956014
107Impaired vibration sensation in the lower limbs (HP:0002166)1.73917570
108Absent speech (HP:0001344)1.72896618
109Short chin (HP:0000331)1.72620416
110Ankyloglossia (HP:0010296)1.72542458
111Inappropriate behavior (HP:0000719)1.72083538
112Flat acetabular roof (HP:0003180)1.71742442
113Blue irides (HP:0000635)1.70929899
114Abnormality of the epiphyses of the hand (HP:0005924)1.70424866
115Lip pit (HP:0100267)1.70391326
116Cystic hygroma (HP:0000476)1.69796551
117Difficulty running (HP:0009046)1.68091215
118Patellar dislocation (HP:0002999)1.67593191
119Abnormality of the ischium (HP:0003174)1.67009381
120Megalocornea (HP:0000485)1.65706667
121Ectopic kidney (HP:0000086)1.65682600
122Eczematoid dermatitis (HP:0000976)1.65200188
123Recurrent fungal infections (HP:0002841)1.64758432
124Deeply set eye (HP:0000490)1.64695728
125Sacral dimple (HP:0000960)1.63540482
126Abnormal ciliary motility (HP:0012262)1.63183242
127Mild short stature (HP:0003502)1.63144705
128Hypopigmentation of the fundus (HP:0007894)1.62698153
129Abnormality of oral frenula (HP:0000190)1.61890731
130Neoplasm of the heart (HP:0100544)1.61790366
131Tubulointerstitial nephritis (HP:0001970)1.61559892
132Stereotypic behavior (HP:0000733)1.61527529
133Thick eyebrow (HP:0000574)1.61521934
134Fair hair (HP:0002286)1.61031042
135Rhinitis (HP:0012384)1.60521977
136Abnormality of incisor morphology (HP:0011063)1.60023266
137Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59727435
138Macrotia (HP:0000400)1.59432774
139Insidious onset (HP:0003587)1.59143663
140Termporal pattern (HP:0011008)1.59143663
141Thyroiditis (HP:0100646)1.56372450
142Hyperventilation (HP:0002883)1.56119990
143Metaphyseal cupping (HP:0003021)1.55351024
144Abnormal large intestine physiology (HP:0012700)1.54566743
145Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.54384723
146Agammaglobulinemia (HP:0004432)1.53987704
147Aortic aneurysm (HP:0004942)1.53793779
148Hypoplasia of the maxilla (HP:0000327)1.53404480
149Truncal obesity (HP:0001956)1.53114754
150Cellulitis (HP:0100658)1.53089134
151Menstrual irregularities (HP:0000858)1.52239901
152Autism (HP:0000717)1.50935756
153Sparse lateral eyebrow (HP:0005338)1.50399117
154Abnormality of salivation (HP:0100755)1.50032184
155Coarse hair (HP:0002208)1.49937964
156Acute myeloid leukemia (HP:0004808)1.49808075
157Absent eyebrow (HP:0002223)1.49688386
158Tented upper lip vermilion (HP:0010804)1.49203725
159Panhypogammaglobulinemia (HP:0003139)1.49060383
160Onion bulb formation (HP:0003383)1.48838976
161Smooth philtrum (HP:0000319)1.48274348
162Nephronophthisis (HP:0000090)1.48028135
163Abnormality of chromosome segregation (HP:0002916)1.47874833
164Open mouth (HP:0000194)1.47483287
165Abnormality of the incisor (HP:0000676)1.47251576
166Disproportionate tall stature (HP:0001519)1.46840887
167Deep palmar crease (HP:0006191)1.46617470
168Aneurysm (HP:0002617)1.46616666
169Gingivitis (HP:0000230)1.45478561
170Heterotopia (HP:0002282)1.45109229
171Hypoplastic ischia (HP:0003175)1.44910059
172Laryngomalacia (HP:0001601)1.44290424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.86912330
2TRIB33.05829040
3NTRK32.97764098
4EEF2K2.72563129
5MAP3K102.49695190
6SGK22.46370067
7SIK22.37777447
8MAP2K72.19024907
9EPHA42.18142203
10ICK2.10531197
11FGFR42.09976757
12SGK32.07904060
13MARK12.04737999
14MAP3K41.92669354
15AKT31.90779856
16NTRK21.88285304
17FRK1.84144503
18MAP3K91.77986612
19TNIK1.69148457
20MAP3K21.68385219
21FGFR31.60195866
22PRPF4B1.55904061
23FGFR21.54207638
24SIK31.52083137
25YES11.50115247
26MAPK131.47828394
27SGK4941.46419215
28SGK2231.46419215
29KSR21.45170534
30BRD41.44160007
31TNK21.40620016
32TXK1.38431951
33NLK1.38375208
34RIPK41.37661202
35PKN21.36632410
36PDGFRB1.33524657
37PDGFRA1.32622946
38CAMK1G1.29729234
39MKNK21.28312607
40ZAK1.27760331
41MTOR1.26616552
42CDK61.23226724
43MAPK111.13287377
44JAK11.13229526
45NEK61.11761788
46TTN1.08816051
47MAP2K31.07969514
48CASK1.05603779
49DAPK21.01732419
50MINK11.01009517
51CAMKK10.99788330
52SMG10.99293452
53MAP3K140.98079733
54ERBB30.96934408
55PLK20.96826217
56SGK10.96392591
57PRKD30.91073906
58CDK120.90145622
59NUAK10.90105289
60CAMK1D0.88833753
61PRKCH0.87980967
62WNK10.87080308
63FES0.86437893
64BTK0.86208107
65BLK0.85934106
66CLK10.85251986
67CDK40.85054641
68MAP3K60.84705620
69JAK20.82731648
70TRPM70.81303797
71BMPR20.80611729
72HCK0.80229750
73CCNB10.79991257
74CDK50.79525469
75MARK20.79203748
76RIPK10.78689218
77MAP3K130.76621963
78DMPK0.76020627
79ZAP700.75189405
80HIPK20.75165319
81DYRK1A0.73426876
82PDPK10.72439862
83ITK0.71723080
84GRK10.71702962
85CDK30.70966473
86SYK0.70455077
87NEK90.69989136
88RPS6KB10.68676452
89ERN10.68565337
90MAP3K10.67809838
91MAPK70.67177128
92LATS10.67125457
93JAK30.66884849
94MAP2K40.65716800
95ALK0.65580232
96MAPK120.63905721
97PDK30.63881373
98PDK40.63881373
99PRKCQ0.63244741
100EPHA30.62522038
101CAMK40.62399524
102MAP3K70.62009133
103MAPK100.61602895
104PKN10.61571214
105STK110.61054845
106SIK10.59359543
107RET0.56109060
108STK380.56003611
109ATR0.55830037
110PIK3CG0.55808610
111CAMK10.55504580
112KSR10.54095030
113STK30.54019229
114PAK60.53167405
115PNCK0.53031558
116PDK10.52313160
117ATM0.50778365
118STK240.50752426
119CDK90.50541821
120TEC0.50015853
121PTK60.49709151
122PRKAA20.48990949
123CSNK1A1L0.48769024
124EPHB10.48028914
125TYK20.47959136
126RAF10.47938416
127MKNK10.47663767
128PRKAA10.47216352
129FYN0.45859905
130MAPK80.45317684
131PASK0.44568313
132RPS6KB20.44237788
133RPS6KL10.43456290
134RPS6KC10.43456290
135TYRO30.43340515
136GSK3B0.43127204
137MAPK140.43006346
138MELK0.42511329
139CDC42BPA0.42466110
140PIK3CA0.42440666
141MAP4K10.42403772
142CHEK10.42369051
143RPS6KA20.42284953
144ERBB20.41351938
145SCYL20.40165051
146LCK0.40051431
147MARK30.39998576

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.34494611
2Olfactory transduction_Homo sapiens_hsa047401.91955060
3Long-term potentiation_Homo sapiens_hsa047201.91623435
4Morphine addiction_Homo sapiens_hsa050321.91117305
5Circadian entrainment_Homo sapiens_hsa047131.90715428
6Glutamatergic synapse_Homo sapiens_hsa047241.87064471
7Acute myeloid leukemia_Homo sapiens_hsa052211.79593074
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.77451090
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73558895
10Amphetamine addiction_Homo sapiens_hsa050311.68038324
11Renal cell carcinoma_Homo sapiens_hsa052111.48687285
12Salivary secretion_Homo sapiens_hsa049701.48067404
13Dorso-ventral axis formation_Homo sapiens_hsa043201.46574365
14Gastric acid secretion_Homo sapiens_hsa049711.45813179
15Type II diabetes mellitus_Homo sapiens_hsa049301.43761717
16GABAergic synapse_Homo sapiens_hsa047271.43096781
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41788545
18Cholinergic synapse_Homo sapiens_hsa047251.41721203
19Dopaminergic synapse_Homo sapiens_hsa047281.41417981
20Renin secretion_Homo sapiens_hsa049241.38793799
21Taste transduction_Homo sapiens_hsa047421.37833902
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36688089
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36329493
24Long-term depression_Homo sapiens_hsa047301.30921937
25VEGF signaling pathway_Homo sapiens_hsa043701.28141125
26Insulin secretion_Homo sapiens_hsa049111.27240610
27ErbB signaling pathway_Homo sapiens_hsa040121.25341505
28Oxytocin signaling pathway_Homo sapiens_hsa049211.23918866
29Thyroid cancer_Homo sapiens_hsa052161.22908997
30Calcium signaling pathway_Homo sapiens_hsa040201.20581574
31Adherens junction_Homo sapiens_hsa045201.18484567
32Primary immunodeficiency_Homo sapiens_hsa053401.16608525
33Glioma_Homo sapiens_hsa052141.15755117
34T cell receptor signaling pathway_Homo sapiens_hsa046601.14781619
35cAMP signaling pathway_Homo sapiens_hsa040241.12992491
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12774302
37Serotonergic synapse_Homo sapiens_hsa047261.12188979
38Inositol phosphate metabolism_Homo sapiens_hsa005621.10762917
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05399789
40Small cell lung cancer_Homo sapiens_hsa052221.05140967
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04928212
42Cocaine addiction_Homo sapiens_hsa050301.03895193
43Synaptic vesicle cycle_Homo sapiens_hsa047211.02101038
44MAPK signaling pathway_Homo sapiens_hsa040101.00734759
45GnRH signaling pathway_Homo sapiens_hsa049120.99882437
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99449687
47Insulin signaling pathway_Homo sapiens_hsa049100.98516679
48Choline metabolism in cancer_Homo sapiens_hsa052310.98446005
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97155225
50Notch signaling pathway_Homo sapiens_hsa043300.96659521
51Non-small cell lung cancer_Homo sapiens_hsa052230.96370361
52Insulin resistance_Homo sapiens_hsa049310.96012831
53Estrogen signaling pathway_Homo sapiens_hsa049150.95172187
54B cell receptor signaling pathway_Homo sapiens_hsa046620.95104481
55Endometrial cancer_Homo sapiens_hsa052130.94829005
56Phototransduction_Homo sapiens_hsa047440.94813803
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94559600
58Chemokine signaling pathway_Homo sapiens_hsa040620.93664259
59Axon guidance_Homo sapiens_hsa043600.93114958
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92675280
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.91397232
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.91318303
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91227473
64Chronic myeloid leukemia_Homo sapiens_hsa052200.89879417
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88252126
66Focal adhesion_Homo sapiens_hsa045100.86403511
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85913691
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.84628043
69Hepatitis C_Homo sapiens_hsa051600.83478941
70FoxO signaling pathway_Homo sapiens_hsa040680.81950250
71Proteoglycans in cancer_Homo sapiens_hsa052050.81712933
72Influenza A_Homo sapiens_hsa051640.80845619
73Toxoplasmosis_Homo sapiens_hsa051450.80285727
74mTOR signaling pathway_Homo sapiens_hsa041500.80255574
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.80209799
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77716206
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77650992
78Melanogenesis_Homo sapiens_hsa049160.77509538
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77489332
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.77038861
81Viral carcinogenesis_Homo sapiens_hsa052030.76605045
82Wnt signaling pathway_Homo sapiens_hsa043100.76300206
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76095410
84Prolactin signaling pathway_Homo sapiens_hsa049170.75125385
85mRNA surveillance pathway_Homo sapiens_hsa030150.74052685
86Rap1 signaling pathway_Homo sapiens_hsa040150.73755580
87Ras signaling pathway_Homo sapiens_hsa040140.72779620
88Osteoclast differentiation_Homo sapiens_hsa043800.72668599
89Alcoholism_Homo sapiens_hsa050340.72193343
90Gap junction_Homo sapiens_hsa045400.71969259
91Colorectal cancer_Homo sapiens_hsa052100.71772682
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.70189393
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70050046
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69757332
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.69665654
96ABC transporters_Homo sapiens_hsa020100.69579421
97Thyroid hormone synthesis_Homo sapiens_hsa049180.69575254
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.69435375
99Platelet activation_Homo sapiens_hsa046110.69167792
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68519216
101HIF-1 signaling pathway_Homo sapiens_hsa040660.67747040
102AMPK signaling pathway_Homo sapiens_hsa041520.67414014
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67404036
104Oocyte meiosis_Homo sapiens_hsa041140.66969317
105Fanconi anemia pathway_Homo sapiens_hsa034600.66918577
106Circadian rhythm_Homo sapiens_hsa047100.66694283
107Leishmaniasis_Homo sapiens_hsa051400.65372454
108Pancreatic cancer_Homo sapiens_hsa052120.64388575
109Measles_Homo sapiens_hsa051620.64338701
110TNF signaling pathway_Homo sapiens_hsa046680.64330406
111MicroRNAs in cancer_Homo sapiens_hsa052060.64221779
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62043653
113HTLV-I infection_Homo sapiens_hsa051660.61017665
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.60862807
115Prostate cancer_Homo sapiens_hsa052150.60230145
116Non-homologous end-joining_Homo sapiens_hsa034500.60149194
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58300260
118Pathways in cancer_Homo sapiens_hsa052000.57761374
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57160773
120Lysine degradation_Homo sapiens_hsa003100.56585270
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55723286
122Glucagon signaling pathway_Homo sapiens_hsa049220.55439896
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55383312
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54557677
125Fatty acid biosynthesis_Homo sapiens_hsa000610.54365358
126Amoebiasis_Homo sapiens_hsa051460.54226732
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53268143
128Pancreatic secretion_Homo sapiens_hsa049720.52833784
129Apoptosis_Homo sapiens_hsa042100.52680897
130Herpes simplex infection_Homo sapiens_hsa051680.52351721
131Hepatitis B_Homo sapiens_hsa051610.51961355
132Dilated cardiomyopathy_Homo sapiens_hsa054140.51875870
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51350910
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.51296196
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51048851
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50846621

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