

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.16775081 |
| 2 | viral transcription (GO:0019083) | 5.25261573 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 5.16481614 |
| 4 | ribosomal small subunit assembly (GO:0000028) | 5.12701264 |
| 5 | translational termination (GO:0006415) | 5.11955464 |
| 6 | ribosomal small subunit biogenesis (GO:0042274) | 4.90677154 |
| 7 | proteasome assembly (GO:0043248) | 4.90059219 |
| 8 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.64852817 |
| 9 | translational elongation (GO:0006414) | 4.62448914 |
| 10 | cotranslational protein targeting to membrane (GO:0006613) | 4.57077379 |
| 11 | protein targeting to ER (GO:0045047) | 4.53557305 |
| 12 | formation of translation preinitiation complex (GO:0001731) | 4.53404390 |
| 13 | translational initiation (GO:0006413) | 4.52109295 |
| 14 | ribosomal large subunit biogenesis (GO:0042273) | 4.46779469 |
| 15 | nucleobase biosynthetic process (GO:0046112) | 4.45671454 |
| 16 | purine nucleobase biosynthetic process (GO:0009113) | 4.44863025 |
| 17 | ATP synthesis coupled proton transport (GO:0015986) | 4.35288670 |
| 18 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.35288670 |
| 19 | protein localization to endoplasmic reticulum (GO:0070972) | 4.31901115 |
| 20 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.29591001 |
| 21 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.15739002 |
| 22 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.14067413 |
| 23 | pseudouridine synthesis (GO:0001522) | 4.11069029 |
| 24 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.09261653 |
| 25 | termination of RNA polymerase III transcription (GO:0006386) | 4.09261653 |
| 26 | viral life cycle (GO:0019058) | 4.08418056 |
| 27 | cellular protein complex disassembly (GO:0043624) | 4.07780334 |
| 28 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.02724303 |
| 29 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.01172088 |
| 30 | translation (GO:0006412) | 3.97478883 |
| 31 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.86637351 |
| 32 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.86630997 |
| 33 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.84570588 |
| 34 | DNA strand elongation (GO:0022616) | 3.82160512 |
| 35 | ribosome biogenesis (GO:0042254) | 3.81728542 |
| 36 | negative regulation of ligase activity (GO:0051352) | 3.81550957 |
| 37 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.81550957 |
| 38 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.79958458 |
| 39 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.79072696 |
| 40 | rRNA processing (GO:0006364) | 3.78648715 |
| 41 | GDP-mannose metabolic process (GO:0019673) | 3.77827712 |
| 42 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.66393819 |
| 43 | rRNA metabolic process (GO:0016072) | 3.65514055 |
| 44 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.64902258 |
| 45 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.60846219 |
| 46 | rRNA modification (GO:0000154) | 3.60496031 |
| 47 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.58876077 |
| 48 | DNA replication initiation (GO:0006270) | 3.54811427 |
| 49 | ribosome assembly (GO:0042255) | 3.53132036 |
| 50 | protein complex disassembly (GO:0043241) | 3.52879260 |
| 51 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.52724817 |
| 52 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.51884681 |
| 53 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.51884681 |
| 54 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.51602313 |
| 55 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.51602313 |
| 56 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.51602313 |
| 57 | cellular component biogenesis (GO:0044085) | 3.49774821 |
| 58 | respiratory electron transport chain (GO:0022904) | 3.47275831 |
| 59 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.45030762 |
| 60 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.45030762 |
| 61 | spliceosomal snRNP assembly (GO:0000387) | 3.43910544 |
| 62 | 7-methylguanosine mRNA capping (GO:0006370) | 3.43521332 |
| 63 | DNA replication checkpoint (GO:0000076) | 3.40825640 |
| 64 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.40053098 |
| 65 | electron transport chain (GO:0022900) | 3.40014665 |
| 66 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.39170780 |
| 67 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.39068576 |
| 68 | 7-methylguanosine RNA capping (GO:0009452) | 3.37612971 |
| 69 | RNA capping (GO:0036260) | 3.37612971 |
| 70 | protein localization to mitochondrion (GO:0070585) | 3.37542362 |
| 71 | rRNA methylation (GO:0031167) | 3.37433522 |
| 72 | macromolecular complex disassembly (GO:0032984) | 3.36854098 |
| 73 | base-excision repair, AP site formation (GO:0006285) | 3.35819130 |
| 74 | establishment of viral latency (GO:0019043) | 3.35734410 |
| 75 | regulation of mitochondrial translation (GO:0070129) | 3.35627392 |
| 76 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.33437335 |
| 77 | protein maturation by protein folding (GO:0022417) | 3.30388267 |
| 78 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.29149996 |
| 79 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.28986735 |
| 80 | telomere maintenance via recombination (GO:0000722) | 3.28693689 |
| 81 | transcription from RNA polymerase I promoter (GO:0006360) | 3.28129466 |
| 82 | positive regulation of ligase activity (GO:0051351) | 3.28044826 |
| 83 | protein complex biogenesis (GO:0070271) | 3.25313825 |
| 84 | protein deneddylation (GO:0000338) | 3.23657070 |
| 85 | cullin deneddylation (GO:0010388) | 3.22446226 |
| 86 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.20002492 |
| 87 | peptidyl-histidine modification (GO:0018202) | 3.18496231 |
| 88 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.18029380 |
| 89 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.17507717 |
| 90 | termination of RNA polymerase I transcription (GO:0006363) | 3.14686395 |
| 91 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.14550359 |
| 92 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.13917586 |
| 93 | mitotic metaphase plate congression (GO:0007080) | 3.13053942 |
| 94 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.12867778 |
| 95 | L-methionine salvage (GO:0071267) | 3.12782408 |
| 96 | L-methionine biosynthetic process (GO:0071265) | 3.12782408 |
| 97 | amino acid salvage (GO:0043102) | 3.12782408 |
| 98 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.11279295 |
| 99 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.11279295 |
| 100 | transcription from mitochondrial promoter (GO:0006390) | 3.10317207 |
| 101 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.10262410 |
| 102 | oxidative phosphorylation (GO:0006119) | 3.10004977 |
| 103 | protein targeting to mitochondrion (GO:0006626) | 3.06179434 |
| 104 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.06075508 |
| 105 | NADH dehydrogenase complex assembly (GO:0010257) | 3.06075508 |
| 106 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.06075508 |
| 107 | CENP-A containing nucleosome assembly (GO:0034080) | 3.05550445 |
| 108 | establishment of integrated proviral latency (GO:0075713) | 3.05513417 |
| 109 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.05437713 |
| 110 | chromatin remodeling at centromere (GO:0031055) | 3.05337916 |
| 111 | cell cycle G1/S phase transition (GO:0044843) | 3.04902371 |
| 112 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.04902371 |
| 113 | regulation of translational termination (GO:0006449) | 3.04467646 |
| 114 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.03761817 |
| 115 | establishment of protein localization to mitochondrion (GO:0072655) | 3.03636300 |
| 116 | UTP biosynthetic process (GO:0006228) | 3.02094689 |
| 117 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.01664446 |
| 118 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.01119199 |
| 119 | folic acid metabolic process (GO:0046655) | 3.00748131 |
| 120 | telomere maintenance via telomere lengthening (GO:0010833) | 3.00391603 |
| 121 | cytochrome complex assembly (GO:0017004) | 3.00046189 |
| 122 | GTP biosynthetic process (GO:0006183) | 2.97685654 |
| 123 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.97659940 |
| 124 | chaperone-mediated protein transport (GO:0072321) | 2.97057863 |
| 125 | protein targeting to membrane (GO:0006612) | 2.96583749 |
| 126 | DNA unwinding involved in DNA replication (GO:0006268) | 2.95726902 |
| 127 | mRNA catabolic process (GO:0006402) | 2.95563609 |
| 128 | mitotic recombination (GO:0006312) | 2.95079402 |
| 129 | regulation of ligase activity (GO:0051340) | 2.93987048 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.05730864 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.28319107 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.01259225 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.82601830 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.56174958 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.52269314 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.38323979 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.34318719 |
| 9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.33532046 |
| 10 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.12224452 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.05702216 |
| 12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.93360443 |
| 13 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.90966612 |
| 14 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.77995989 |
| 15 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.77243349 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.57498088 |
| 17 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.50870414 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.47500566 |
| 19 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.47454053 |
| 20 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.44016574 |
| 21 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.31560379 |
| 22 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.23879860 |
| 23 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.21774643 |
| 24 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.21325405 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.20471909 |
| 26 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.13371671 |
| 27 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.03776216 |
| 28 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.03210722 |
| 29 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.02814253 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.01204798 |
| 31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.97711226 |
| 32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.91574585 |
| 33 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.90115175 |
| 34 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.87153717 |
| 35 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.76648060 |
| 36 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.76132859 |
| 37 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70434735 |
| 38 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.68514837 |
| 39 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.68218711 |
| 40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.61018229 |
| 41 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.60451033 |
| 42 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.57002887 |
| 43 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.56772432 |
| 44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.55055271 |
| 45 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.54263736 |
| 46 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.52273612 |
| 47 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.48384494 |
| 48 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.47528920 |
| 49 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.44794320 |
| 50 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.44478723 |
| 51 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.43528131 |
| 52 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37831105 |
| 53 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.37446449 |
| 54 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.36769933 |
| 55 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.35296815 |
| 56 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.34852026 |
| 57 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.33516300 |
| 58 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.29873982 |
| 59 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.29827990 |
| 60 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.29300771 |
| 61 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.24142995 |
| 62 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.22703571 |
| 63 | MYC_22102868_ChIP-Seq_BL_Human | 1.20685994 |
| 64 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.19607170 |
| 65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.18929868 |
| 66 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.17674573 |
| 67 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.17370740 |
| 68 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.16988396 |
| 69 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.14764634 |
| 70 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.14492389 |
| 71 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.13192315 |
| 72 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.09907381 |
| 73 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.09564310 |
| 74 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.08042813 |
| 75 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.05826023 |
| 76 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.05702179 |
| 77 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.04269919 |
| 78 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.03303898 |
| 79 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.02013877 |
| 80 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.01890576 |
| 81 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.00459745 |
| 82 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99447488 |
| 83 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.99059315 |
| 84 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.97467487 |
| 85 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.96983086 |
| 86 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.96643914 |
| 87 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.96586446 |
| 88 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.96442886 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.96054754 |
| 90 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.94230875 |
| 91 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.94083364 |
| 92 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.93426969 |
| 93 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.92605060 |
| 94 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.92042784 |
| 95 | * P68_20966046_ChIP-Seq_HELA_Human | 0.91185379 |
| 96 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.89969455 |
| 97 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.89396348 |
| 98 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.89284719 |
| 99 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88768476 |
| 100 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.87484835 |
| 101 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87112565 |
| 102 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.86263038 |
| 103 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.86051957 |
| 104 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.85900887 |
| 105 | MAF_26560356_Chip-Seq_TH2_Human | 0.84929178 |
| 106 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.84343739 |
| 107 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.83349634 |
| 108 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.83170332 |
| 109 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.81568878 |
| 110 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.81367137 |
| 111 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.80278993 |
| 112 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.80113156 |
| 113 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.78880940 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 6.35365599 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.54704578 |
| 3 | MP0003111_abnormal_nucleus_morphology | 3.69283039 |
| 4 | MP0003077_abnormal_cell_cycle | 3.40040884 |
| 5 | MP0010094_abnormal_chromosome_stability | 3.27745039 |
| 6 | MP0008057_abnormal_DNA_replication | 3.26956105 |
| 7 | MP0003806_abnormal_nucleotide_metabolis | 2.99597066 |
| 8 | MP0008058_abnormal_DNA_repair | 2.87407385 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.73130136 |
| 10 | MP0003718_maternal_effect | 2.53195016 |
| 11 | MP0002396_abnormal_hematopoietic_system | 2.36158723 |
| 12 | MP0003186_abnormal_redox_activity | 2.19775518 |
| 13 | MP0009333_abnormal_splenocyte_physiolog | 2.10018457 |
| 14 | MP0008007_abnormal_cellular_replicative | 2.08354633 |
| 15 | MP0000490_abnormal_crypts_of | 2.01992756 |
| 16 | MP0009379_abnormal_foot_pigmentation | 2.01216143 |
| 17 | MP0001730_embryonic_growth_arrest | 1.91081884 |
| 18 | MP0006036_abnormal_mitochondrial_physio | 1.90738868 |
| 19 | MP0010234_abnormal_vibrissa_follicle | 1.89404632 |
| 20 | MP0003786_premature_aging | 1.84878342 |
| 21 | MP0001986_abnormal_taste_sensitivity | 1.78106268 |
| 22 | MP0009840_abnormal_foam_cell | 1.73592137 |
| 23 | MP0006035_abnormal_mitochondrial_morpho | 1.72228525 |
| 24 | MP0003763_abnormal_thymus_physiology | 1.70123330 |
| 25 | MP0000350_abnormal_cell_proliferation | 1.66885976 |
| 26 | MP0008260_abnormal_autophagy | 1.65526896 |
| 27 | MP0005501_abnormal_skin_physiology | 1.63692942 |
| 28 | MP0002019_abnormal_tumor_incidence | 1.54939714 |
| 29 | MP0000358_abnormal_cell_content/ | 1.53666585 |
| 30 | MP0002132_abnormal_respiratory_system | 1.50890082 |
| 31 | MP0003656_abnormal_erythrocyte_physiolo | 1.49291448 |
| 32 | MP0005075_abnormal_melanosome_morpholog | 1.43067561 |
| 33 | MP0005671_abnormal_response_to | 1.39507865 |
| 34 | MP0000313_abnormal_cell_death | 1.38950711 |
| 35 | MP0001853_heart_inflammation | 1.36767113 |
| 36 | MP0000689_abnormal_spleen_morphology | 1.36675604 |
| 37 | MP0002398_abnormal_bone_marrow | 1.36330823 |
| 38 | MP0001835_abnormal_antigen_presentation | 1.34967306 |
| 39 | MP0002722_abnormal_immune_system | 1.34617611 |
| 40 | MP0002877_abnormal_melanocyte_morpholog | 1.32406323 |
| 41 | MP0005397_hematopoietic_system_phenotyp | 1.31843964 |
| 42 | MP0001545_abnormal_hematopoietic_system | 1.31843964 |
| 43 | MP0009785_altered_susceptibility_to | 1.31341986 |
| 44 | MP0002080_prenatal_lethality | 1.28013242 |
| 45 | MP0003315_abnormal_perineum_morphology | 1.26644353 |
| 46 | MP0003123_paternal_imprinting | 1.23603795 |
| 47 | MP0002429_abnormal_blood_cell | 1.21695936 |
| 48 | MP0001697_abnormal_embryo_size | 1.21051762 |
| 49 | MP0002796_impaired_skin_barrier | 1.20063085 |
| 50 | MP0008995_early_reproductive_senescence | 1.19451412 |
| 51 | MP0010352_gastrointestinal_tract_polyps | 1.17708354 |
| 52 | MP0001873_stomach_inflammation | 1.16326617 |
| 53 | MP0000858_altered_metastatic_potential | 1.16283804 |
| 54 | MP0000716_abnormal_immune_system | 1.15578347 |
| 55 | MP0002420_abnormal_adaptive_immunity | 1.13308962 |
| 56 | MP0003221_abnormal_cardiomyocyte_apopto | 1.13263292 |
| 57 | MP0003866_abnormal_defecation | 1.12283761 |
| 58 | MP0009697_abnormal_copulation | 1.12049900 |
| 59 | MP0001819_abnormal_immune_cell | 1.11713450 |
| 60 | MP0005174_abnormal_tail_pigmentation | 1.10621927 |
| 61 | MP0002148_abnormal_hypersensitivity_rea | 1.09884302 |
| 62 | MP0005000_abnormal_immune_tolerance | 1.07502853 |
| 63 | MP0001800_abnormal_humoral_immune | 1.07330842 |
| 64 | MP0005025_abnormal_response_to | 1.06291729 |
| 65 | MP0008875_abnormal_xenobiotic_pharmacok | 1.06245796 |
| 66 | MP0000703_abnormal_thymus_morphology | 1.06086633 |
| 67 | MP0004233_abnormal_muscle_weight | 1.05228487 |
| 68 | MP0002723_abnormal_immune_serum | 1.05221163 |
| 69 | MP0002938_white_spotting | 1.03561290 |
| 70 | MP0001672_abnormal_embryogenesis/_devel | 1.02949451 |
| 71 | MP0005380_embryogenesis_phenotype | 1.02949451 |
| 72 | MP0005451_abnormal_body_composition | 1.02524449 |
| 73 | MP0002452_abnormal_antigen_presenting | 1.00152839 |
| 74 | MP0001881_abnormal_mammary_gland | 0.97291713 |
| 75 | MP0001764_abnormal_homeostasis | 0.97282092 |
| 76 | MP0000465_gastrointestinal_hemorrhage | 0.96856164 |
| 77 | MP0005083_abnormal_biliary_tract | 0.96355951 |
| 78 | MP0008877_abnormal_DNA_methylation | 0.96044638 |
| 79 | MP0009278_abnormal_bone_marrow | 0.95229543 |
| 80 | MP0005058_abnormal_lysosome_morphology | 0.92884108 |
| 81 | MP0002751_abnormal_autonomic_nervous | 0.91531411 |
| 82 | MP0005330_cardiomyopathy | 0.89864025 |
| 83 | MP0002163_abnormal_gland_morphology | 0.89579768 |
| 84 | MP0006292_abnormal_olfactory_placode | 0.89492838 |
| 85 | MP0000685_abnormal_immune_system | 0.87662714 |
| 86 | MP0003984_embryonic_growth_retardation | 0.86407846 |
| 87 | MP0001905_abnormal_dopamine_level | 0.84322588 |
| 88 | MP0010307_abnormal_tumor_latency | 0.83947262 |
| 89 | MP0002160_abnormal_reproductive_system | 0.83746529 |
| 90 | MP0002088_abnormal_embryonic_growth/wei | 0.82831961 |
| 91 | MP0002736_abnormal_nociception_after | 0.82289863 |
| 92 | MP0001929_abnormal_gametogenesis | 0.81561412 |
| 93 | MP0002210_abnormal_sex_determination | 0.80810197 |
| 94 | MP0000372_irregular_coat_pigmentation | 0.80385895 |
| 95 | MP0005384_cellular_phenotype | 0.79766909 |
| 96 | MP0001145_abnormal_male_reproductive | 0.79638052 |
| 97 | MP0001727_abnormal_embryo_implantation | 0.79220964 |
| 98 | MP0003567_abnormal_fetal_cardiomyocyte | 0.78631613 |
| 99 | MP0005408_hypopigmentation | 0.78533840 |
| 100 | MP0002085_abnormal_embryonic_tissue | 0.77982707 |
| 101 | MP0005084_abnormal_gallbladder_morpholo | 0.77977556 |
| 102 | MP0008873_increased_physiological_sensi | 0.77518724 |
| 103 | MP0001216_abnormal_epidermal_layer | 0.77459197 |
| 104 | MP0002405_respiratory_system_inflammati | 0.77324092 |
| 105 | MP0005389_reproductive_system_phenotype | 0.76796774 |
| 106 | MP0001529_abnormal_vocalization | 0.76056927 |
| 107 | MP0004147_increased_porphyrin_level | 0.75676079 |
| 108 | MP0004808_abnormal_hematopoietic_stem | 0.75595208 |
| 109 | MP0001542_abnormal_bone_strength | 0.73624644 |
| 110 | MP0005332_abnormal_amino_acid | 0.73461035 |
| 111 | MP0000613_abnormal_salivary_gland | 0.73405570 |
| 112 | MP0002006_tumorigenesis | 0.72997752 |
| 113 | MP0006082_CNS_inflammation | 0.72501917 |
| 114 | MP0002277_abnormal_respiratory_mucosa | 0.72274880 |
| 115 | MP0003436_decreased_susceptibility_to | 0.71780116 |
| 116 | MP0000750_abnormal_muscle_regeneration | 0.71705994 |
| 117 | MP0001919_abnormal_reproductive_system | 0.70692815 |
| 118 | MP0008469_abnormal_protein_level | 0.70383044 |
| 119 | MP0000015_abnormal_ear_pigmentation | 0.69775611 |
| 120 | MP0001845_abnormal_inflammatory_respons | 0.68890629 |
| 121 | MP0000653_abnormal_sex_gland | 0.68657085 |
| 122 | MP0010155_abnormal_intestine_physiology | 0.68069800 |
| 123 | MP0002086_abnormal_extraembryonic_tissu | 0.66845086 |
| 124 | MP0002419_abnormal_innate_immunity | 0.66578353 |
| 125 | MP0001661_extended_life_span | 0.66324696 |
| 126 | MP0001346_abnormal_lacrimal_gland | 0.66187685 |
| 127 | MP0002095_abnormal_skin_pigmentation | 0.66021944 |
| 128 | MP0002234_abnormal_pharynx_morphology | 0.64948257 |
| 129 | MP0003136_yellow_coat_color | 0.64797703 |
| 130 | MP0005266_abnormal_metabolism | 0.64177461 |
| 131 | MP0005621_abnormal_cell_physiology | 0.63599678 |
| 132 | MP0005319_abnormal_enzyme/_coenzyme | 0.63415677 |
| 133 | MP0008789_abnormal_olfactory_epithelium | 0.58454738 |
| 134 | MP0000627_abnormal_mammary_gland | 0.58097245 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.51501875 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.06880640 |
| 3 | Cerebral hypomyelination (HP:0006808) | 4.68078795 |
| 4 | Reticulocytopenia (HP:0001896) | 4.55793777 |
| 5 | Aplastic anemia (HP:0001915) | 4.34315529 |
| 6 | Oral leukoplakia (HP:0002745) | 4.00049371 |
| 7 | Birth length less than 3rd percentile (HP:0003561) | 3.99615949 |
| 8 | Macrocytic anemia (HP:0001972) | 3.91187847 |
| 9 | Testicular atrophy (HP:0000029) | 3.78492596 |
| 10 | Breast hypoplasia (HP:0003187) | 3.73378451 |
| 11 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.52936138 |
| 12 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.52936138 |
| 13 | Rough bone trabeculation (HP:0100670) | 3.48622913 |
| 14 | Hepatocellular necrosis (HP:0001404) | 3.44424182 |
| 15 | Pallor (HP:0000980) | 3.41751489 |
| 16 | Cerebral edema (HP:0002181) | 3.41061789 |
| 17 | 3-Methylglutaconic aciduria (HP:0003535) | 3.27917276 |
| 18 | Mitochondrial inheritance (HP:0001427) | 3.25612553 |
| 19 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.16824160 |
| 20 | Hepatic necrosis (HP:0002605) | 3.07475660 |
| 21 | Increased CSF lactate (HP:0002490) | 3.07210630 |
| 22 | Acute necrotizing encephalopathy (HP:0006965) | 3.06884387 |
| 23 | Increased serum lactate (HP:0002151) | 3.02077984 |
| 24 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.99309693 |
| 25 | Abnormality of glycolysis (HP:0004366) | 2.86666835 |
| 26 | Increased serum pyruvate (HP:0003542) | 2.86666835 |
| 27 | Carpal bone hypoplasia (HP:0001498) | 2.86060298 |
| 28 | Increased hepatocellular lipid droplets (HP:0006565) | 2.82364541 |
| 29 | Colon cancer (HP:0003003) | 2.81221999 |
| 30 | Ragged-red muscle fibers (HP:0003200) | 2.78278046 |
| 31 | Multiple enchondromatosis (HP:0005701) | 2.74106816 |
| 32 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.72557721 |
| 33 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.68299609 |
| 34 | CNS hypomyelination (HP:0003429) | 2.66474533 |
| 35 | Premature ovarian failure (HP:0008209) | 2.64376407 |
| 36 | Degeneration of anterior horn cells (HP:0002398) | 2.62396924 |
| 37 | Abnormality of the anterior horn cell (HP:0006802) | 2.62396924 |
| 38 | Pancytopenia (HP:0001876) | 2.60812333 |
| 39 | Trismus (HP:0000211) | 2.59807112 |
| 40 | Exertional dyspnea (HP:0002875) | 2.57820692 |
| 41 | Microretrognathia (HP:0000308) | 2.57635893 |
| 42 | Sparse eyelashes (HP:0000653) | 2.57592707 |
| 43 | Lipid accumulation in hepatocytes (HP:0006561) | 2.55928167 |
| 44 | Secondary amenorrhea (HP:0000869) | 2.55208474 |
| 45 | Chronic otitis media (HP:0000389) | 2.52842163 |
| 46 | Poor head control (HP:0002421) | 2.52267212 |
| 47 | Acute encephalopathy (HP:0006846) | 2.49529806 |
| 48 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.46286158 |
| 49 | Type I transferrin isoform profile (HP:0003642) | 2.45814100 |
| 50 | Abnormal trabecular bone morphology (HP:0100671) | 2.45128891 |
| 51 | Renal Fanconi syndrome (HP:0001994) | 2.45017047 |
| 52 | Thrombocytosis (HP:0001894) | 2.44945414 |
| 53 | Chromsome breakage (HP:0040012) | 2.42104413 |
| 54 | Premature graying of hair (HP:0002216) | 2.41194929 |
| 55 | Abnormality of small intestinal villus morphology (HP:0011472) | 2.41055785 |
| 56 | Villous atrophy (HP:0011473) | 2.41055785 |
| 57 | Dicarboxylic aciduria (HP:0003215) | 2.38243900 |
| 58 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.38243900 |
| 59 | Progressive muscle weakness (HP:0003323) | 2.32121000 |
| 60 | Lactic acidosis (HP:0003128) | 2.31514288 |
| 61 | Amniotic constriction ring (HP:0009775) | 2.30546685 |
| 62 | Abnormality of placental membranes (HP:0011409) | 2.30546685 |
| 63 | CNS demyelination (HP:0007305) | 2.29677735 |
| 64 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.25592986 |
| 65 | Emotional lability (HP:0000712) | 2.24192025 |
| 66 | Respiratory failure (HP:0002878) | 2.22807065 |
| 67 | Postnatal microcephaly (HP:0005484) | 2.22539996 |
| 68 | Abnormality of the umbilical cord (HP:0010881) | 2.20820237 |
| 69 | Cleft eyelid (HP:0000625) | 2.19062843 |
| 70 | Hypertensive crisis (HP:0100735) | 2.18979380 |
| 71 | Respiratory difficulties (HP:0002880) | 2.16846446 |
| 72 | Meckel diverticulum (HP:0002245) | 2.15394694 |
| 73 | Exercise intolerance (HP:0003546) | 2.15320089 |
| 74 | Patellar aplasia (HP:0006443) | 2.15172449 |
| 75 | Bone marrow hypocellularity (HP:0005528) | 2.14782266 |
| 76 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.14401352 |
| 77 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.14075398 |
| 78 | Progressive macrocephaly (HP:0004481) | 2.14014836 |
| 79 | Abnormality of renal resorption (HP:0011038) | 2.13619095 |
| 80 | Squamous cell carcinoma (HP:0002860) | 2.11733340 |
| 81 | Increased intramyocellular lipid droplets (HP:0012240) | 2.11598229 |
| 82 | Leukodystrophy (HP:0002415) | 2.11387349 |
| 83 | Progressive microcephaly (HP:0000253) | 2.10738124 |
| 84 | Microvesicular hepatic steatosis (HP:0001414) | 2.10387772 |
| 85 | Lethargy (HP:0001254) | 2.10319191 |
| 86 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.08944525 |
| 87 | Petechiae (HP:0000967) | 2.07969190 |
| 88 | Death in infancy (HP:0001522) | 2.06826132 |
| 89 | Megaloblastic anemia (HP:0001889) | 2.05512809 |
| 90 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.05383861 |
| 91 | Abnormality of alanine metabolism (HP:0010916) | 2.05383861 |
| 92 | Hyperalaninemia (HP:0003348) | 2.05383861 |
| 93 | Abnormality of the ileum (HP:0001549) | 2.05315930 |
| 94 | IgM deficiency (HP:0002850) | 2.04372315 |
| 95 | Panhypogammaglobulinemia (HP:0003139) | 2.02678619 |
| 96 | Delusions (HP:0000746) | 2.02532054 |
| 97 | Abnormality of the preputium (HP:0100587) | 2.01695283 |
| 98 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.01412228 |
| 99 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.00899180 |
| 100 | Agnosia (HP:0010524) | 1.99285290 |
| 101 | Hypoplasia of the pons (HP:0012110) | 1.98693519 |
| 102 | Absent thumb (HP:0009777) | 1.98615715 |
| 103 | Personality changes (HP:0000751) | 1.97865106 |
| 104 | Methylmalonic aciduria (HP:0012120) | 1.97716202 |
| 105 | Muscle fiber atrophy (HP:0100295) | 1.97427338 |
| 106 | Poikiloderma (HP:0001029) | 1.97137329 |
| 107 | Optic disc pallor (HP:0000543) | 1.95944936 |
| 108 | Opisthotonus (HP:0002179) | 1.95905375 |
| 109 | Neoplasm of the pancreas (HP:0002894) | 1.93305511 |
| 110 | Generalized aminoaciduria (HP:0002909) | 1.92796506 |
| 111 | Congenital, generalized hypertrichosis (HP:0004540) | 1.90182110 |
| 112 | Spastic paraparesis (HP:0002313) | 1.89341798 |
| 113 | Horseshoe kidney (HP:0000085) | 1.88918031 |
| 114 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.88390617 |
| 115 | Tongue fasciculations (HP:0001308) | 1.86669923 |
| 116 | Neoplasm of head and neck (HP:0012288) | 1.84559028 |
| 117 | Esophageal neoplasm (HP:0100751) | 1.84559028 |
| 118 | Glossoptosis (HP:0000162) | 1.82769108 |
| 119 | Cellular immunodeficiency (HP:0005374) | 1.81630224 |
| 120 | Ureteral duplication (HP:0000073) | 1.81621401 |
| 121 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.81496672 |
| 122 | Abnormality of the pons (HP:0007361) | 1.79984661 |
| 123 | Increased muscle lipid content (HP:0009058) | 1.79416052 |
| 124 | Abnormality of T cell physiology (HP:0011840) | 1.78256099 |
| 125 | Erythema (HP:0010783) | 1.77977496 |
| 126 | Abnormal protein glycosylation (HP:0012346) | 1.77766164 |
| 127 | Abnormal glycosylation (HP:0012345) | 1.77766164 |
| 128 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.77766164 |
| 129 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.77766164 |
| 130 | Selective tooth agenesis (HP:0001592) | 1.77579605 |
| 131 | Reduced antithrombin III activity (HP:0001976) | 1.76738646 |
| 132 | Recurrent cutaneous fungal infections (HP:0011370) | 1.75773217 |
| 133 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.75773217 |
| 134 | Hypokinesia (HP:0002375) | 1.75271129 |
| 135 | Myelodysplasia (HP:0002863) | 1.74639767 |
| 136 | Abnormality of chromosome stability (HP:0003220) | 1.74536225 |
| 137 | Hypergonadotropic hypogonadism (HP:0000815) | 1.71374826 |
| 138 | Hepatosplenomegaly (HP:0001433) | 1.68200119 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.02581756 |
| 2 | VRK2 | 4.89495433 |
| 3 | NME2 | 4.61253379 |
| 4 | STK16 | 3.82624464 |
| 5 | WEE1 | 3.63887895 |
| 6 | TESK2 | 3.20635988 |
| 7 | PIM2 | 2.84339605 |
| 8 | EIF2AK1 | 2.54319050 |
| 9 | VRK1 | 2.39121741 |
| 10 | PBK | 2.29766501 |
| 11 | SMG1 | 2.23049570 |
| 12 | TLK1 | 2.17282644 |
| 13 | EIF2AK3 | 1.93061899 |
| 14 | ACVR1B | 1.86182340 |
| 15 | TSSK6 | 1.80678118 |
| 16 | DYRK3 | 1.80139476 |
| 17 | CDC7 | 1.79449683 |
| 18 | RPS6KB2 | 1.65634393 |
| 19 | MAP4K1 | 1.62248811 |
| 20 | MAP3K11 | 1.59079017 |
| 21 | SRPK1 | 1.56576193 |
| 22 | CCNB1 | 1.56386723 |
| 23 | ARAF | 1.53413381 |
| 24 | PLK4 | 1.52229621 |
| 25 | EPHA2 | 1.49648279 |
| 26 | NME1 | 1.47613350 |
| 27 | IRAK3 | 1.47216606 |
| 28 | BRSK2 | 1.45135054 |
| 29 | AURKA | 1.34480014 |
| 30 | NEK2 | 1.29081643 |
| 31 | LIMK1 | 1.28838317 |
| 32 | PLK1 | 1.26685851 |
| 33 | BCKDK | 1.24416793 |
| 34 | TESK1 | 1.22192000 |
| 35 | SCYL2 | 1.21777860 |
| 36 | CDK7 | 1.19134296 |
| 37 | MAPKAPK3 | 1.19030952 |
| 38 | MAP2K2 | 1.17615740 |
| 39 | BRAF | 1.16072150 |
| 40 | TTK | 1.14783798 |
| 41 | RPS6KA4 | 1.13474349 |
| 42 | AURKB | 1.08664740 |
| 43 | CDK19 | 1.07829846 |
| 44 | FLT3 | 1.06869921 |
| 45 | NEK1 | 1.03505020 |
| 46 | MST1R | 1.03349552 |
| 47 | MAP3K8 | 1.02837121 |
| 48 | DYRK2 | 1.01659672 |
| 49 | TAF1 | 1.00786700 |
| 50 | MAP3K3 | 0.99373643 |
| 51 | ZAP70 | 0.98967843 |
| 52 | MAP3K12 | 0.96650715 |
| 53 | PLK3 | 0.95190745 |
| 54 | KDR | 0.95084328 |
| 55 | MAP2K3 | 0.93310282 |
| 56 | BRSK1 | 0.93147394 |
| 57 | KIT | 0.90935104 |
| 58 | ZAK | 0.89760534 |
| 59 | NUAK1 | 0.89657927 |
| 60 | PAK1 | 0.88740423 |
| 61 | NLK | 0.86576084 |
| 62 | TAOK2 | 0.85324842 |
| 63 | ERN1 | 0.84967491 |
| 64 | PAK4 | 0.84774244 |
| 65 | PASK | 0.84188288 |
| 66 | CHEK2 | 0.83488703 |
| 67 | GRK6 | 0.83272806 |
| 68 | PRKCI | 0.82734171 |
| 69 | PIM1 | 0.79893128 |
| 70 | MST4 | 0.78961722 |
| 71 | ABL2 | 0.78224281 |
| 72 | ICK | 0.77973832 |
| 73 | STK10 | 0.74448061 |
| 74 | CDK8 | 0.74011828 |
| 75 | LRRK2 | 0.73045124 |
| 76 | ATR | 0.69184245 |
| 77 | BMPR1B | 0.67166859 |
| 78 | CSNK2A1 | 0.66628128 |
| 79 | CSNK2A2 | 0.66499124 |
| 80 | MUSK | 0.66197345 |
| 81 | IKBKB | 0.65339939 |
| 82 | TRIM28 | 0.62464601 |
| 83 | STK4 | 0.61591958 |
| 84 | CSF1R | 0.61379092 |
| 85 | TGFBR1 | 0.61124382 |
| 86 | TEC | 0.59904731 |
| 87 | EEF2K | 0.59717310 |
| 88 | PDK2 | 0.58784753 |
| 89 | RPS6KA5 | 0.57059632 |
| 90 | CSNK1G3 | 0.56943540 |
| 91 | MATK | 0.56232091 |
| 92 | MKNK1 | 0.55239788 |
| 93 | ILK | 0.55037826 |
| 94 | MAPK11 | 0.54610868 |
| 95 | BTK | 0.54564913 |
| 96 | TRIB3 | 0.53698634 |
| 97 | BLK | 0.53341088 |
| 98 | CLK1 | 0.53137033 |
| 99 | MAP2K6 | 0.52852505 |
| 100 | SYK | 0.52815042 |
| 101 | CSNK1A1L | 0.52530470 |
| 102 | MAPKAPK5 | 0.52394395 |
| 103 | IKBKE | 0.51437830 |
| 104 | WNK4 | 0.51326990 |
| 105 | SIK3 | 0.51063313 |
| 106 | CDK9 | 0.50026881 |
| 107 | TBK1 | 0.48598529 |
| 108 | CHEK1 | 0.47092135 |
| 109 | DAPK3 | 0.46677484 |
| 110 | MAPK4 | 0.45516378 |
| 111 | CSNK1G1 | 0.44930495 |
| 112 | GRK5 | 0.44174279 |
| 113 | TAOK1 | 0.42019810 |
| 114 | DAPK1 | 0.41348323 |
| 115 | CDK4 | 0.40414483 |
| 116 | LYN | 0.40119361 |
| 117 | EIF2AK2 | 0.38380646 |
| 118 | MAPK15 | 0.38227493 |
| 119 | TXK | 0.34621348 |
| 120 | ATM | 0.33712775 |
| 121 | YES1 | 0.32315695 |
| 122 | CDK2 | 0.32232157 |
| 123 | RAF1 | 0.32028011 |
| 124 | ADRBK2 | 0.31435463 |
| 125 | MKNK2 | 0.30128320 |
| 126 | MAP3K5 | 0.29270602 |
| 127 | IRAK2 | 0.28639126 |
| 128 | ALK | 0.28039293 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.01349833 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.63220338 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 4.06079834 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.87087069 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.34036593 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 3.26699084 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 2.88306405 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.76043682 |
| 9 | Spliceosome_Homo sapiens_hsa03040 | 2.68385849 |
| 10 | RNA transport_Homo sapiens_hsa03013 | 2.45547640 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.29917868 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.29461799 |
| 13 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.00669054 |
| 14 | Protein export_Homo sapiens_hsa03060 | 1.99582274 |
| 15 | Parkinsons disease_Homo sapiens_hsa05012 | 1.93652181 |
| 16 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.88579562 |
| 17 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.80840857 |
| 18 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.80655422 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.76678644 |
| 20 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.73408286 |
| 21 | Cell cycle_Homo sapiens_hsa04110 | 1.60961477 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.48833782 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.48546573 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.45136813 |
| 25 | RNA degradation_Homo sapiens_hsa03018 | 1.41375392 |
| 26 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.39810279 |
| 27 | Sulfur relay system_Homo sapiens_hsa04122 | 1.38669379 |
| 28 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.33607554 |
| 29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.24528652 |
| 30 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.21456244 |
| 31 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.20692401 |
| 32 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.11535369 |
| 33 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.11209571 |
| 34 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.09697542 |
| 35 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.08764243 |
| 36 | Alzheimers disease_Homo sapiens_hsa05010 | 1.02674032 |
| 37 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.02012621 |
| 38 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.96005347 |
| 39 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.94508871 |
| 40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.90744339 |
| 41 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.89976154 |
| 42 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.88815346 |
| 43 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.82583090 |
| 44 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.76740144 |
| 45 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.71433631 |
| 46 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.71394639 |
| 47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.69659235 |
| 48 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.69503653 |
| 49 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.68907447 |
| 50 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.65738157 |
| 51 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.63008704 |
| 52 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.62303197 |
| 53 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.62138744 |
| 54 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.61955019 |
| 55 | Metabolic pathways_Homo sapiens_hsa01100 | 0.61441731 |
| 56 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.60297584 |
| 57 | Other glycan degradation_Homo sapiens_hsa00511 | 0.56038396 |
| 58 | Legionellosis_Homo sapiens_hsa05134 | 0.55775578 |
| 59 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.52740952 |
| 60 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.52088281 |
| 61 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.50227668 |
| 62 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.49952604 |
| 63 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.49661203 |
| 64 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.49255444 |
| 65 | Shigellosis_Homo sapiens_hsa05131 | 0.48920413 |
| 66 | Carbon metabolism_Homo sapiens_hsa01200 | 0.47104807 |
| 67 | Galactose metabolism_Homo sapiens_hsa00052 | 0.45382896 |
| 68 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.43135662 |
| 69 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.42283831 |
| 70 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.41976408 |
| 71 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.41849949 |
| 72 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.41026159 |
| 73 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.39396387 |
| 74 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.39009676 |
| 75 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.37498436 |
| 76 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.36664059 |
| 77 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.34403521 |
| 78 | Allograft rejection_Homo sapiens_hsa05330 | 0.33918580 |
| 79 | Apoptosis_Homo sapiens_hsa04210 | 0.33369324 |
| 80 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.32091260 |
| 81 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.30913954 |
| 82 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.30845660 |
| 83 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.30411634 |
| 84 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.29542518 |
| 85 | Thyroid cancer_Homo sapiens_hsa05216 | 0.28890491 |
| 86 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.28600792 |
| 87 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.27180072 |
| 88 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.26028878 |
| 89 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.25088676 |
| 90 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.24718331 |
| 91 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.23407728 |
| 92 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.22142047 |
| 93 | Peroxisome_Homo sapiens_hsa04146 | 0.21261794 |
| 94 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.20751814 |
| 95 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.20684834 |
| 96 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.20217508 |
| 97 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.20186628 |
| 98 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.18938220 |
| 99 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.16753158 |
| 100 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.16526999 |
| 101 | HTLV-I infection_Homo sapiens_hsa05166 | 0.15766479 |
| 102 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.15398041 |
| 103 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.14789270 |
| 104 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.14707586 |
| 105 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.14487297 |
| 106 | Alcoholism_Homo sapiens_hsa05034 | 0.14436493 |
| 107 | Lysosome_Homo sapiens_hsa04142 | 0.14302613 |
| 108 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.13763274 |
| 109 | Measles_Homo sapiens_hsa05162 | 0.13398518 |
| 110 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.13184194 |
| 111 | Asthma_Homo sapiens_hsa05310 | 0.12375846 |
| 112 | Viral myocarditis_Homo sapiens_hsa05416 | 0.11504337 |
| 113 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.10382501 |
| 114 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.10171345 |
| 115 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.08206345 |
| 116 | Phagosome_Homo sapiens_hsa04145 | 0.07748264 |
| 117 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.07278581 |

