NR2E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)5.73246231
2cerebral cortex radially oriented cell migration (GO:0021799)5.38534531
3L-amino acid import (GO:0043092)4.66321792
4retinal cone cell development (GO:0046549)4.65569964
5amino acid import (GO:0043090)4.43122672
6positive regulation of cellular amide metabolic process (GO:0034250)4.30169590
7* negative regulation of astrocyte differentiation (GO:0048712)4.20621773
8ovulation cycle (GO:0042698)4.19545405
9atrial cardiac muscle cell action potential (GO:0086014)4.15584078
10pyrimidine nucleobase catabolic process (GO:0006208)4.05821480
11isoprenoid biosynthetic process (GO:0008299)3.77957585
12kidney morphogenesis (GO:0060993)3.76504071
13negative regulation of hormone metabolic process (GO:0032351)3.74423810
14negative regulation of hormone biosynthetic process (GO:0032353)3.74423810
15transmission of nerve impulse (GO:0019226)3.72759790
16cholesterol biosynthetic process (GO:0006695)3.71471907
17adenine nucleotide transport (GO:0051503)3.71119293
18neurotransmitter-gated ion channel clustering (GO:0072578)3.62146412
19regulation of phospholipid biosynthetic process (GO:0071071)3.57539741
20cellular potassium ion homeostasis (GO:0030007)3.56799067
21neuron cell-cell adhesion (GO:0007158)3.55810242
22cerebral cortex cell migration (GO:0021795)3.50555436
23positive regulation of oligodendrocyte differentiation (GO:0048714)3.47950374
24response to lipoprotein particle (GO:0055094)3.47844128
25central nervous system myelination (GO:0022010)3.45666689
26axon ensheathment in central nervous system (GO:0032291)3.45666689
27tongue development (GO:0043586)3.45196748
28axonal fasciculation (GO:0007413)3.44738493
29C4-dicarboxylate transport (GO:0015740)3.44132794
30nonmotile primary cilium assembly (GO:0035058)3.41091510
31cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.36496058
32DNA double-strand break processing (GO:0000729)3.24261814
33regulation of female gonad development (GO:2000194)3.23957469
34nucleobase catabolic process (GO:0046113)3.23561837
35dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.22411175
36retinal rod cell development (GO:0046548)3.18677120
37glial cell proliferation (GO:0014009)3.18126880
38regulation of spindle organization (GO:0090224)3.17407223
39tachykinin receptor signaling pathway (GO:0007217)3.17233460
40negative regulation of oligodendrocyte differentiation (GO:0048715)3.16754325
41auditory behavior (GO:0031223)3.15223756
42response to auditory stimulus (GO:0010996)3.12655207
43cell proliferation in forebrain (GO:0021846)3.12288301
44sterol biosynthetic process (GO:0016126)3.12189083
45oligodendrocyte differentiation (GO:0048709)3.10612993
46neuron recognition (GO:0008038)3.10149920
47postsynaptic membrane organization (GO:0001941)3.08894594
48regulation of meiosis I (GO:0060631)3.05383800
49cilium morphogenesis (GO:0060271)3.04448273
50regulation of DNA methylation (GO:0044030)3.03632818
51regulation of mitotic spindle organization (GO:0060236)3.03538049
52detection of light stimulus involved in sensory perception (GO:0050962)3.03427976
53detection of light stimulus involved in visual perception (GO:0050908)3.03427976
54* negative regulation of glial cell differentiation (GO:0045686)3.03029085
55forebrain neuron differentiation (GO:0021879)3.02979553
56* olfactory bulb development (GO:0021772)3.02786501
57purine nucleotide transport (GO:0015865)3.02322556
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02010567
59neuron fate commitment (GO:0048663)3.01912591
60* regulation of astrocyte differentiation (GO:0048710)2.99360081
61regulation of oligodendrocyte differentiation (GO:0048713)2.98760290
62locomotory exploration behavior (GO:0035641)2.95509034
63intraciliary transport (GO:0042073)2.95331361
64positive regulation of potassium ion transmembrane transport (GO:1901381)2.92710735
65myelination in peripheral nervous system (GO:0022011)2.92632472
66peripheral nervous system axon ensheathment (GO:0032292)2.92632472
67mitotic metaphase plate congression (GO:0007080)2.92415399
68presynaptic membrane assembly (GO:0097105)2.91347021
69forebrain cell migration (GO:0021885)2.89881068
70metaphase plate congression (GO:0051310)2.89415290
71negative regulation of transcription regulatory region DNA binding (GO:2000678)2.89216682
72photoreceptor cell differentiation (GO:0046530)2.88764161
73eye photoreceptor cell differentiation (GO:0001754)2.88764161
74telencephalon cell migration (GO:0022029)2.87830697
75regulation of beta-amyloid formation (GO:1902003)2.87228553
76Notch signaling involved in heart development (GO:0061314)2.86673976
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85617035
78notochord development (GO:0030903)2.85220116
79regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84284846
80negative regulation of smoothened signaling pathway (GO:0045879)2.83481386
81epithelial cilium movement (GO:0003351)2.82325338
82serine family amino acid catabolic process (GO:0009071)2.81820781
83regulation of acrosome reaction (GO:0060046)2.81783283
84presynaptic membrane organization (GO:0097090)2.79830597
85forebrain morphogenesis (GO:0048853)2.79040833
86positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78615699
87limb bud formation (GO:0060174)2.77669209
88regulation of membrane repolarization (GO:0060306)2.75694983
89establishment of mitochondrion localization (GO:0051654)2.74587886
90positive regulation of neuroblast proliferation (GO:0002052)2.73829633
91appendage development (GO:0048736)2.73308740
92limb development (GO:0060173)2.73308740
93chondroitin sulfate catabolic process (GO:0030207)2.72777056
94cellular response to sterol (GO:0036315)2.72435856
95cochlea development (GO:0090102)2.72313699
96substrate-independent telencephalic tangential migration (GO:0021826)2.71749567
97substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.71749567
98negative regulation of homotypic cell-cell adhesion (GO:0034111)2.71455485
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70344034
100dermatan sulfate biosynthetic process (GO:0030208)2.69926844
101spinal cord association neuron differentiation (GO:0021527)2.68929796
102protein heterotetramerization (GO:0051290)2.66632329
103gamma-aminobutyric acid transport (GO:0015812)2.66177059
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64788642
105Sertoli cell development (GO:0060009)2.64281799
106microtubule polymerization or depolymerization (GO:0031109)2.63474649
107endocardial cushion morphogenesis (GO:0003203)2.63423581
108* regulation of timing of cell differentiation (GO:0048505)2.62381639
109dorsal/ventral pattern formation (GO:0009953)2.62198300
110female gonad development (GO:0008585)2.61818518
111heart trabecula morphogenesis (GO:0061384)2.61759750
112cranial nerve structural organization (GO:0021604)2.61284899
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60873447
114cellular response to cholesterol (GO:0071397)2.60518353
115regulation of respiratory gaseous exchange (GO:0043576)2.60502068
116ganglion development (GO:0061548)2.59901819
117smoothened signaling pathway (GO:0007224)2.59703883
118positive regulation of mitotic sister chromatid separation (GO:1901970)2.59660091
119positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.59660091
120positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.59660091
121mechanosensory behavior (GO:0007638)2.59629598
122membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.59230996
123piRNA metabolic process (GO:0034587)2.58726584
124positive regulation of neurological system process (GO:0031646)2.58650131
125metanephric tubule development (GO:0072170)2.58215779
126metanephric nephron tubule development (GO:0072234)2.58215779
127heart valve formation (GO:0003188)2.57967993
128neuron fate determination (GO:0048664)2.56384895
129membrane repolarization (GO:0086009)2.56131950
130brain morphogenesis (GO:0048854)2.55430655
131dermatan sulfate metabolic process (GO:0030205)2.54539928
132positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.54529989
133regulation of synaptic transmission, glutamatergic (GO:0051966)2.53655209
134neuronal stem cell maintenance (GO:0097150)2.53504004
135inner ear receptor stereocilium organization (GO:0060122)2.52500103
136cell differentiation involved in metanephros development (GO:0072202)2.52227858
137regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.51875158
138somatic stem cell division (GO:0048103)2.51026284
139positive regulation of male gonad development (GO:2000020)2.51006033
140protein localization to synapse (GO:0035418)2.50002760
141regulation of respiratory system process (GO:0044065)2.49956236
142multicellular organism reproduction (GO:0032504)2.49085902
143apical protein localization (GO:0045176)2.48734017
144replication fork processing (GO:0031297)2.48608610
145negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48235196
146lens fiber cell development (GO:0070307)2.47916714
147cilium assembly (GO:0042384)2.47806259
148cilium organization (GO:0044782)2.47369167
149central nervous system neuron development (GO:0021954)2.46978006
150negative regulation of axon extension involved in axon guidance (GO:0048843)2.46701904
151regulation of male gonad development (GO:2000018)2.45719410
152positive regulation of alcohol biosynthetic process (GO:1902932)2.45608404
153dendritic spine morphogenesis (GO:0060997)2.45571385
154vocalization behavior (GO:0071625)2.45266609
155regulation of somitogenesis (GO:0014807)2.45045202
156synaptic vesicle endocytosis (GO:0048488)2.44769745
157positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.44584899
158protein localization to cilium (GO:0061512)2.43001438
159kinetochore organization (GO:0051383)2.41683020
160* regulation of development, heterochronic (GO:0040034)2.41012962
161* central nervous system projection neuron axonogenesis (GO:0021952)2.39238501
162resolution of meiotic recombination intermediates (GO:0000712)2.38966793
163photoreceptor cell maintenance (GO:0045494)2.38788041
164negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38708878
165establishment of chromosome localization (GO:0051303)2.38333667
166negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.37455479
167cilium movement (GO:0003341)2.36445089
168meiotic cell cycle (GO:0051321)2.35226264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.64055152
2GBX2_23144817_ChIP-Seq_PC3_Human2.80479047
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76910988
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66335573
5* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60064088
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56344527
7* EED_16625203_ChIP-ChIP_MESCs_Mouse2.55636824
8ZNF274_21170338_ChIP-Seq_K562_Hela2.53263871
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53187675
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.52399992
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51950914
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47202025
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43834161
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43834161
15AR_21572438_ChIP-Seq_LNCaP_Human2.41284578
16* CBX2_27304074_Chip-Seq_ESCs_Mouse2.36489790
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35501415
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.34883909
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.32801090
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29762843
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23249810
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21553819
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.14298788
24* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04255663
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00928582
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.97163784
27* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96362355
28* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91439943
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90197735
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82345119
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81039827
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77770535
33* RNF2_27304074_Chip-Seq_NSC_Mouse1.75146548
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71923412
35TAF15_26573619_Chip-Seq_HEK293_Human1.65654335
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64523451
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.64364220
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62375649
39IGF1R_20145208_ChIP-Seq_DFB_Human1.59577350
40P300_19829295_ChIP-Seq_ESCs_Human1.54592457
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53463131
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51780167
43IRF1_19129219_ChIP-ChIP_H3396_Human1.50329577
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50302598
45* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49023863
46DROSHA_22980978_ChIP-Seq_HELA_Human1.47487853
47SMAD4_21799915_ChIP-Seq_A2780_Human1.46485707
48FUS_26573619_Chip-Seq_HEK293_Human1.43923265
49* RING1B_27294783_Chip-Seq_ESCs_Mouse1.43236126
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41572614
51* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39619823
52* REST_21632747_ChIP-Seq_MESCs_Mouse1.39466460
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38456850
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38178310
55* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.37811781
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35763747
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35600108
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34869060
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.34095389
60* REST_18959480_ChIP-ChIP_MESCs_Mouse1.33953358
61* RING1B_27294783_Chip-Seq_NPCs_Mouse1.33866766
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33298057
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33117562
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31018500
65RXR_22108803_ChIP-Seq_LS180_Human1.29919201
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27074176
67* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26975050
68* CBP_20019798_ChIP-Seq_JUKART_Human1.26975050
69AR_25329375_ChIP-Seq_VCAP_Human1.25007748
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.24531431
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24405209
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24115822
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23566915
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22435048
75JUN_21703547_ChIP-Seq_K562_Human1.21350264
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20844484
77TCF4_23295773_ChIP-Seq_U87_Human1.20741715
78SOX9_26525672_Chip-Seq_HEART_Mouse1.20111114
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19950493
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19703750
81EWS_26573619_Chip-Seq_HEK293_Human1.19223206
82* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18906121
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18531275
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18531275
85VDR_22108803_ChIP-Seq_LS180_Human1.17985558
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.17975889
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17726526
88BCAT_22108803_ChIP-Seq_LS180_Human1.17618435
89TP53_18474530_ChIP-ChIP_U2OS_Human1.17438096
90* TP53_20018659_ChIP-ChIP_R1E_Mouse1.17118737
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14726804
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12983627
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12621981
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12240492
95ER_23166858_ChIP-Seq_MCF-7_Human1.11854852
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.11621395
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10591666
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09258026
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.09040303
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08957570
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.07951903
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07410482
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07374801
104* EZH2_27294783_Chip-Seq_NPCs_Mouse1.06998302
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06710839
106TCF4_22108803_ChIP-Seq_LS180_Human1.06381030
107* STAT3_23295773_ChIP-Seq_U87_Human1.05989125
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05517418
109* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05494312
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.05466533
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05068175
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05009730
113P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04918002
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04349611
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.03960451
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03829220
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.03645380
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03054359
119P53_22387025_ChIP-Seq_ESCs_Mouse1.02853197
120RUNX2_22187159_ChIP-Seq_PCA_Human1.02785313
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02668661
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02472028
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02468389
124ESR1_20079471_ChIP-ChIP_T-47D_Human1.02075282
125KDM2B_26808549_Chip-Seq_REH_Human1.01070172
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00935799
127* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00548236
128RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00242270
129TP63_19390658_ChIP-ChIP_HaCaT_Human1.00103100
130AR_19668381_ChIP-Seq_PC3_Human0.99781685
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99176099
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97739766
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97596037
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.97579751
135FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96888028
136AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95222037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.06938845
2MP0005646_abnormal_pituitary_gland4.08030476
3MP0000566_synostosis3.98368694
4MP0002653_abnormal_ependyma_morphology3.01887178
5MP0008789_abnormal_olfactory_epithelium2.76143759
6MP0004859_abnormal_synaptic_plasticity2.57763883
7MP0003136_yellow_coat_color2.53730951
8MP0010030_abnormal_orbit_morphology2.50549428
9MP0005499_abnormal_olfactory_system2.50230334
10MP0005394_taste/olfaction_phenotype2.50230334
11MP0002234_abnormal_pharynx_morphology2.41406433
12MP0000049_abnormal_middle_ear2.25074641
13MP0003690_abnormal_glial_cell2.24615546
14MP0002249_abnormal_larynx_morphology2.24392348
15* MP0000778_abnormal_nervous_system2.18953545
16MP0008877_abnormal_DNA_methylation2.06360888
17MP0002102_abnormal_ear_morphology2.05274037
18MP0001486_abnormal_startle_reflex2.04937440
19MP0000631_abnormal_neuroendocrine_gland2.03645930
20MP0003880_abnormal_central_pattern1.93909218
21MP0002638_abnormal_pupillary_reflex1.91665336
22MP0006276_abnormal_autonomic_nervous1.89052755
23MP0001346_abnormal_lacrimal_gland1.81403894
24MP0005248_abnormal_Harderian_gland1.80430680
25MP0001501_abnormal_sleep_pattern1.78118353
26MP0009780_abnormal_chondrocyte_physiolo1.74754174
27MP0003938_abnormal_ear_development1.72399989
28MP0003646_muscle_fatigue1.72021465
29MP0003635_abnormal_synaptic_transmissio1.71420472
30MP0001293_anophthalmia1.71283917
31MP0004858_abnormal_nervous_system1.65763301
32MP0001502_abnormal_circadian_rhythm1.65580858
33MP0000026_abnormal_inner_ear1.60408278
34MP0001905_abnormal_dopamine_level1.59771414
35MP0004885_abnormal_endolymph1.59430637
36MP0009384_cardiac_valve_regurgitation1.59166394
37* MP0002063_abnormal_learning/memory/cond1.57118965
38MP0005423_abnormal_somatic_nervous1.54383309
39MP0009745_abnormal_behavioral_response1.53180725
40MP0003787_abnormal_imprinting1.49428314
41MP0002254_reproductive_system_inflammat1.47769468
42MP0002233_abnormal_nose_morphology1.43653961
43MP0006072_abnormal_retinal_apoptosis1.43312223
44MP0001984_abnormal_olfaction1.43254693
45MP0002734_abnormal_mechanical_nocicepti1.41487039
46* MP0002557_abnormal_social/conspecific_i1.41453629
47MP0003121_genomic_imprinting1.40266715
48MP0009250_abnormal_appendicular_skeleto1.40174955
49MP0003718_maternal_effect1.39767512
50MP0003937_abnormal_limbs/digits/tail_de1.37193787
51MP0005379_endocrine/exocrine_gland_phen1.37043227
52MP0002064_seizures1.32268470
53* MP0002572_abnormal_emotion/affect_behav1.31331839
54MP0001177_atelectasis1.27512163
55MP0005645_abnormal_hypothalamus_physiol1.25831890
56MP0003329_amyloid_beta_deposits1.24096957
57MP0003755_abnormal_palate_morphology1.22091536
58MP0002116_abnormal_craniofacial_bone1.21749738
59MP0008058_abnormal_DNA_repair1.21380843
60MP0010368_abnormal_lymphatic_system1.20890944
61MP0001485_abnormal_pinna_reflex1.19690694
62MP0000428_abnormal_craniofacial_morphol1.18574640
63MP0001963_abnormal_hearing_physiology1.16892716
64MP0002092_abnormal_eye_morphology1.14773771
65MP0003942_abnormal_urinary_system1.14065609
66MP0003122_maternal_imprinting1.13806094
67MP0005187_abnormal_penis_morphology1.13761956
68MP0003011_delayed_dark_adaptation1.12865054
69MP0003890_abnormal_embryonic-extraembry1.11554043
70* MP0002882_abnormal_neuron_morphology1.09307641
71MP0001440_abnormal_grooming_behavior1.06074852
72MP0004270_analgesia1.05474437
73* MP0002152_abnormal_brain_morphology1.04063057
74MP0000579_abnormal_nail_morphology1.03874849
75MP0010094_abnormal_chromosome_stability1.03519723
76* MP0002752_abnormal_somatic_nervous1.03056116
77MP0004742_abnormal_vestibular_system1.02973171
78MP0001968_abnormal_touch/_nociception1.02619877
79MP0002736_abnormal_nociception_after1.02563937
80* MP0005551_abnormal_eye_electrophysiolog1.02397119
81MP0004043_abnormal_pH_regulation1.02359872
82MP0002822_catalepsy1.01381639
83MP0003119_abnormal_digestive_system1.01167234
84* MP0003861_abnormal_nervous_system1.00315809
85MP0005253_abnormal_eye_physiology0.99319845
86MP0002184_abnormal_innervation0.98772440
87MP0008569_lethality_at_weaning0.98314225
88MP0002272_abnormal_nervous_system0.95537230
89MP0003878_abnormal_ear_physiology0.95387397
90MP0005377_hearing/vestibular/ear_phenot0.95387397
91MP0002697_abnormal_eye_size0.94857145
92MP0001929_abnormal_gametogenesis0.94477763
93MP0004924_abnormal_behavior0.94409165
94MP0005386_behavior/neurological_phenoty0.94409165
95MP0009046_muscle_twitch0.94404876
96MP0002282_abnormal_trachea_morphology0.93882508
97MP0002735_abnormal_chemical_nociception0.91810554
98MP0003632_abnormal_nervous_system0.91690547
99* MP0002067_abnormal_sensory_capabilities0.91346521
100MP0002733_abnormal_thermal_nociception0.91110924
101* MP0005195_abnormal_posterior_eye0.90628096
102MP0004811_abnormal_neuron_physiology0.89771622
103MP0002210_abnormal_sex_determination0.89455831
104MP0000427_abnormal_hair_cycle0.87865778
105MP0004142_abnormal_muscle_tone0.87452230
106MP0000462_abnormal_digestive_system0.86272678
107MP0000383_abnormal_hair_follicle0.86083017
108MP0001324_abnormal_eye_pigmentation0.84570025
109MP0005395_other_phenotype0.83866883
110MP0001970_abnormal_pain_threshold0.83769361
111MP0003698_abnormal_male_reproductive0.83549190
112MP0000955_abnormal_spinal_cord0.82973375
113MP0005647_abnormal_sex_gland0.81362247
114MP0000653_abnormal_sex_gland0.81314929
115MP0005171_absent_coat_pigmentation0.79919759
116MP0000569_abnormal_digit_pigmentation0.79671972
117MP0003077_abnormal_cell_cycle0.78461176
118MP0000647_abnormal_sebaceous_gland0.77550796
119MP0002132_abnormal_respiratory_system0.77054235
120MP0002751_abnormal_autonomic_nervous0.76803568
121MP0008932_abnormal_embryonic_tissue0.76703545
122MP0001529_abnormal_vocalization0.76365228
123MP0009053_abnormal_anal_canal0.73436280
124MP0003631_nervous_system_phenotype0.72675874
125MP0000534_abnormal_ureter_morphology0.71818042
126MP0005391_vision/eye_phenotype0.70823299
127MP0000678_abnormal_parathyroid_gland0.70577302
128MP0000537_abnormal_urethra_morphology0.70209730
129MP0001119_abnormal_female_reproductive0.69458143
130MP0003385_abnormal_body_wall0.67784376
131MP0005408_hypopigmentation0.66327224
132MP0002066_abnormal_motor_capabilities/c0.66064409
133* MP0003634_abnormal_glial_cell0.65983642

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the extremities (HP:0009825)5.70778756
2Aplasia involving bones of the upper limbs (HP:0009823)5.70778756
3Aplasia of the phalanges of the hand (HP:0009802)5.70778756
4Megalencephaly (HP:0001355)4.66086418
5Abnormality of the middle phalanges of the toes (HP:0010183)3.66756093
6Humeroradial synostosis (HP:0003041)3.57805490
7Synostosis involving the elbow (HP:0003938)3.57805490
8Septo-optic dysplasia (HP:0100842)3.46556189
9Medial flaring of the eyebrow (HP:0010747)3.15023558
10Long nose (HP:0003189)2.97610150
11Short 4th metacarpal (HP:0010044)2.93859822
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93859822
13Decreased central vision (HP:0007663)2.91574079
14Hyperglycinemia (HP:0002154)2.86618436
15Fibular aplasia (HP:0002990)2.84148106
16Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.80669026
17Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.79403644
18Chronic hepatic failure (HP:0100626)2.73189540
19Absent septum pellucidum (HP:0001331)2.72367110
20Oligodactyly (HP:0012165)2.72330508
21Aplasia/Hypoplasia of the sternum (HP:0006714)2.69594082
22Colon cancer (HP:0003003)2.66428588
23Split foot (HP:0001839)2.65029777
24Short hallux (HP:0010109)2.64990609
25Abnormality of the phalanges of the 5th finger (HP:0004213)2.62025718
26Abnormality of the proximal phalanges of the hand (HP:0009834)2.61547192
27True hermaphroditism (HP:0010459)2.59440753
28Postaxial foot polydactyly (HP:0001830)2.58131699
29Genital tract atresia (HP:0001827)2.58115227
30Myokymia (HP:0002411)2.55802491
31Postaxial hand polydactyly (HP:0001162)2.54601585
32Cutaneous syndactyly (HP:0012725)2.54358040
33Symphalangism affecting the phalanges of the hand (HP:0009773)2.49727428
34Epileptic encephalopathy (HP:0200134)2.48950150
35Abnormal lung lobation (HP:0002101)2.48626726
36Vaginal atresia (HP:0000148)2.43734260
37Morphological abnormality of the middle ear (HP:0008609)2.42508373
38Adactyly (HP:0009776)2.40183855
39Attenuation of retinal blood vessels (HP:0007843)2.40059911
40Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.39839859
41Optic nerve hypoplasia (HP:0000609)2.39549476
42Abnormality of the metopic suture (HP:0005556)2.38233906
43Cortical dysplasia (HP:0002539)2.36116062
44Broad hallux (HP:0010055)2.32650748
45Abnormality of chromosome segregation (HP:0002916)2.32441073
46Impulsivity (HP:0100710)2.30747276
47Coronal craniosynostosis (HP:0004440)2.30622639
48Hypoplastic left heart (HP:0004383)2.30530110
49Short tibia (HP:0005736)2.29549092
50Renal hypoplasia (HP:0000089)2.28297651
51Aplasia/Hypoplasia of the hallux (HP:0008362)2.27974824
52Drooling (HP:0002307)2.27531921
53Excessive salivation (HP:0003781)2.27531921
54Abnormality of the phalanges of the 2nd finger (HP:0009541)2.25628257
55Adrenal hypoplasia (HP:0000835)2.22940584
56Clumsiness (HP:0002312)2.22874787
57Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.22862594
58Abnormality of the axillary hair (HP:0100134)2.22557921
59Abnormality of secondary sexual hair (HP:0009888)2.22557921
60Retinal dysplasia (HP:0007973)2.21885354
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21792535
62Aplasia/Hypoplasia of the tibia (HP:0005772)2.20915138
63Bifid scrotum (HP:0000048)2.20128255
64Pancreatic fibrosis (HP:0100732)2.20051191
65Abnormality of the septum pellucidum (HP:0007375)2.19750942
66Focal motor seizures (HP:0011153)2.17852767
67Abnormality of the 4th metacarpal (HP:0010012)2.17358324
68Microglossia (HP:0000171)2.17150045
69Poor coordination (HP:0002370)2.17021581
70Sex reversal (HP:0012245)2.16076993
71Abnormal sex determination (HP:0012244)2.16076993
72Broad foot (HP:0001769)2.15694107
73Hyperventilation (HP:0002883)2.15208550
74Long clavicles (HP:0000890)2.14985727
75Cutaneous finger syndactyly (HP:0010554)2.13783258
76Abnormality of the renal medulla (HP:0100957)2.11675406
77Oligodactyly (hands) (HP:0001180)2.11269280
78Median cleft lip (HP:0000161)2.10963781
79Maternal diabetes (HP:0009800)2.10016496
80Chorioretinal atrophy (HP:0000533)2.06481704
81Specific learning disability (HP:0001328)2.05310654
82Mixed hearing impairment (HP:0000410)2.04457280
83Abnormality of the columella (HP:0009929)2.03136334
84Chromsome breakage (HP:0040012)2.02980372
85High anterior hairline (HP:0009890)2.01042832
86Preaxial hand polydactyly (HP:0001177)2.00895811
87Obstructive sleep apnea (HP:0002870)2.00089427
88Abnormality of the antihelix (HP:0009738)1.99326122
89Aplasia/Hypoplasia of the fovea (HP:0008060)1.97586356
90Hypoplasia of the fovea (HP:0007750)1.97586356
91Calcaneovalgus deformity (HP:0001848)1.97075672
92Abnormality of macular pigmentation (HP:0008002)1.97008184
93Midline defect of the nose (HP:0004122)1.96414114
94Hemiparesis (HP:0001269)1.96374446
95Neurofibrillary tangles (HP:0002185)1.96095871
96Papillary thyroid carcinoma (HP:0002895)1.95863806
97Occipital encephalocele (HP:0002085)1.95761319
98Deformed tarsal bones (HP:0008119)1.95712303
99Hepatoblastoma (HP:0002884)1.95432416
100Cystic liver disease (HP:0006706)1.94524342
101Bile duct proliferation (HP:0001408)1.94365263
102Abnormal biliary tract physiology (HP:0012439)1.94365263
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94307359
104Abnormality of the dental pulp (HP:0006479)1.94060920
105Abnormality of the diencephalon (HP:0010662)1.93321544
106Sclerocornea (HP:0000647)1.92890087
107Gait imbalance (HP:0002141)1.91983695
108Aplasia/Hypoplasia of the lens (HP:0008063)1.91104703
109Cupped ear (HP:0000378)1.90736140
110Hypoplastic heart (HP:0001961)1.90334166
111Multicystic kidney dysplasia (HP:0000003)1.89606038
112Preaxial foot polydactyly (HP:0001841)1.88700225
113Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88544141
114Facial hemangioma (HP:0000329)1.88299269
115Duplication of thumb phalanx (HP:0009942)1.87585819
116Pendular nystagmus (HP:0012043)1.87461243
117Abnormality of serine family amino acid metabolism (HP:0010894)1.86425463
118Abnormality of glycine metabolism (HP:0010895)1.86425463
119Abnormality of the dental root (HP:0006486)1.86133043
120Taurodontia (HP:0000679)1.86133043
121Abnormality of permanent molar morphology (HP:0011071)1.86133043
122Anencephaly (HP:0002323)1.85341061
123Abnormality of the fovea (HP:0000493)1.85112362
124Abnormality of the phalanges of the hallux (HP:0010057)1.84568359
125Pachygyria (HP:0001302)1.84294289
126Abnormality of the labia minora (HP:0012880)1.84199395
127Vitreoretinal degeneration (HP:0000655)1.83375134
128Thickened helices (HP:0000391)1.82912761
129Dyskinesia (HP:0100660)1.82708016
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.82634537
131Intestinal atresia (HP:0011100)1.82303041
132Micropenis (HP:0000054)1.82162223
133Astigmatism (HP:0000483)1.81375575
134Broad toe (HP:0001837)1.81165226
135Narrow forehead (HP:0000341)1.81075559
136Volvulus (HP:0002580)1.80860368
137Pancreatic cysts (HP:0001737)1.80573356
138Narrow nasal bridge (HP:0000446)1.80504401
139Aplasia/Hypoplasia of the fibula (HP:0006492)1.80488415
140Abnormality of the nasal septum (HP:0000419)1.79982513
141Renal dysplasia (HP:0000110)1.79812321
142Broad alveolar ridges (HP:0000187)1.78302573
143Supernumerary spleens (HP:0009799)1.78037425
144Nephronophthisis (HP:0000090)1.77813343
145Decreased testicular size (HP:0008734)1.76796405
146Abnormality of incisor morphology (HP:0011063)1.76495213
147Abnormality of midbrain morphology (HP:0002418)1.76397434
148Molar tooth sign on MRI (HP:0002419)1.76397434
149Partial duplication of thumb phalanx (HP:0009944)1.75949453
150Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75496221
151Congenital primary aphakia (HP:0007707)1.75002827
152Bony spicule pigmentary retinopathy (HP:0007737)1.74599165
153Abnormality of molar (HP:0011077)1.74130138
154Abnormality of molar morphology (HP:0011070)1.74130138
155Progressive microcephaly (HP:0000253)1.73721631
156Action tremor (HP:0002345)1.73079400
157Abnormality of salivation (HP:0100755)1.73049398
158Tubulointerstitial nephritis (HP:0001970)1.72387796
159Nephrogenic diabetes insipidus (HP:0009806)1.72327436
160Absent toe (HP:0010760)1.71610605
161Abnormality of the aortic arch (HP:0012303)1.71189702
162Lissencephaly (HP:0001339)1.70815359
163Hyperglycinuria (HP:0003108)1.70172032
164Gonadotropin excess (HP:0000837)1.68654787
165Abnormal ciliary motility (HP:0012262)1.68602790
166Tented upper lip vermilion (HP:0010804)1.68448588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.83359425
2CASK4.10963435
3NTRK23.38110683
4LMTK23.24679400
5EPHB22.84759641
6MAP4K22.77385577
7MUSK2.75294469
8TNIK2.48349183
9PHKG22.35499710
10PHKG12.35499710
11CSNK1A1L2.28837098
12BCR2.24725847
13PRKD32.21920175
14CSNK1G32.21344271
15CSNK1G22.15207284
16CSNK1G12.06316524
17CCNB12.06004800
18SGK22.02766650
19MAPK132.02200673
20NUAK12.00491769
21MAP3K41.95995910
22ERBB41.93127888
23INSRR1.86903256
24ZAK1.86243008
25TRIM281.81980881
26WNK31.81267835
27SGK4941.78948911
28SGK2231.78948911
29LATS11.71346483
30BMPR21.65357077
31IRAK21.64951206
32ERBB31.63387126
33MAP2K71.62153725
34BCKDK1.54251376
35EPHA31.53568262
36MKNK21.53491243
37BUB11.52879437
38NEK91.51299468
39CDK191.48366692
40IRAK11.47617194
41MARK11.46883944
42BRSK21.46500391
43WEE11.46167183
44SRPK11.46040608
45NTRK31.40773476
46CDK31.37386871
47PAK61.37210644
48PRPF4B1.37047442
49LATS21.35683682
50IRAK31.32455310
51MAPK151.31647726
52NEK61.29385956
53SGK31.26609715
54UHMK11.21522888
55GRK11.18384409
56TAOK11.17467202
57MAP3K61.16402401
58PINK11.15644138
59FGR1.15335605
60PLK31.13123966
61PAK31.12366951
62DYRK21.11240039
63BRSK11.08183438
64ARAF1.06584473
65PLK11.04784677
66KSR11.03449168
67MAPK70.98932615
68CDK80.97612918
69KSR20.94482604
70SIK10.94217092
71MAP3K90.91469624
72PLK20.91433037
73NLK0.90521868
74DMPK0.88434918
75STK390.86578059
76BMPR1B0.80920660
77DYRK30.80518302
78RPS6KA40.79828303
79PRKD20.79810940
80FRK0.79336957
81VRK10.78248306
82MARK20.77465088
83TYRO30.77204897
84MKNK10.74089729
85MAP3K130.71525516
86STK38L0.70606462
87MOS0.69362538
88PRKCE0.69060491
89ATR0.68856894
90AURKA0.68309262
91NEK10.68277445
92CHEK20.66036205
93CDK50.64115366
94PKN10.62618211
95TTK0.62429879
96CAMK2A0.62322214
97PNCK0.60639976
98DYRK1A0.59909425
99SGK10.54972376
100NTRK10.53554502
101PRKCG0.51911620
102BRAF0.50944808
103PRKAA20.50708056
104ATM0.50094048
105HIPK20.49051763
106SIK20.48330730
107CDC70.48158891
108PRKCI0.47441698
109VRK20.47371100
110PLK40.47235567
111MST40.46436798
112CAMKK20.45790823
113ROCK20.45752967
114CLK10.45598681
115ROCK10.45202402
116ERBB20.44860275
117AURKB0.44518485
118MAPK120.44292822
119CSNK1D0.42862568
120NEK20.42674456
121FGFR20.42431255
122WNK40.40625143
123TNK20.40371596
124PIK3CA0.40348659
125CAMKK10.35692165
126CDK150.35211566
127CDK180.35146757
128MAPKAPK50.33371852
129YES10.32600253
130RAF10.32273644
131ADRBK20.31646381
132CAMK1G0.31645225
133CSNK1A10.30822230
134AKT10.30385203
135STK380.30011896
136MINK10.29732833
137IRAK40.28201933
138CDK11A0.27715502
139PBK0.27660656
140RPS6KB10.27196666
141GSK3B0.26660532
142PRKCZ0.26017090
143CDK140.25847473
144CDK90.24595923
145RPS6KA30.24172620
146PRKAA10.24035822
147PRKACA0.23903576
148TIE10.23228091

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.35473000
2Nitrogen metabolism_Homo sapiens_hsa009104.35425225
3Fatty acid biosynthesis_Homo sapiens_hsa000613.25828406
4Nicotine addiction_Homo sapiens_hsa050332.59176823
5Circadian rhythm_Homo sapiens_hsa047102.46141778
6Glutamatergic synapse_Homo sapiens_hsa047242.19206254
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89416847
8Basal cell carcinoma_Homo sapiens_hsa052171.88369671
9Basal transcription factors_Homo sapiens_hsa030221.83000029
10GABAergic synapse_Homo sapiens_hsa047271.79842305
11Axon guidance_Homo sapiens_hsa043601.73761810
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70679357
13Morphine addiction_Homo sapiens_hsa050321.65104364
14Dorso-ventral axis formation_Homo sapiens_hsa043201.64558947
15Homologous recombination_Homo sapiens_hsa034401.63188779
16Propanoate metabolism_Homo sapiens_hsa006401.58975923
17Base excision repair_Homo sapiens_hsa034101.58264388
18Mismatch repair_Homo sapiens_hsa034301.58098567
19Oocyte meiosis_Homo sapiens_hsa041141.56811103
20Cell cycle_Homo sapiens_hsa041101.56722683
21Ovarian steroidogenesis_Homo sapiens_hsa049131.55451333
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47533768
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47443913
24Olfactory transduction_Homo sapiens_hsa047401.47202672
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45934600
26Gastric acid secretion_Homo sapiens_hsa049711.43188203
27Cocaine addiction_Homo sapiens_hsa050301.42306827
28Serotonergic synapse_Homo sapiens_hsa047261.40649461
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.39410701
30Circadian entrainment_Homo sapiens_hsa047131.37855477
31Salivary secretion_Homo sapiens_hsa049701.29011295
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26237882
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26237043
34Protein export_Homo sapiens_hsa030601.24557733
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20580110
36Insulin secretion_Homo sapiens_hsa049111.20454363
37Melanogenesis_Homo sapiens_hsa049161.20438332
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19418958
39Steroid biosynthesis_Homo sapiens_hsa001001.18981434
40African trypanosomiasis_Homo sapiens_hsa051431.17019159
41cAMP signaling pathway_Homo sapiens_hsa040241.16557281
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15765819
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15548621
44Hedgehog signaling pathway_Homo sapiens_hsa043401.14742466
45RNA degradation_Homo sapiens_hsa030181.14152503
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14013881
47Cholinergic synapse_Homo sapiens_hsa047251.12235950
48Long-term depression_Homo sapiens_hsa047301.11961066
49Notch signaling pathway_Homo sapiens_hsa043301.10903323
50Wnt signaling pathway_Homo sapiens_hsa043101.10171617
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10042794
52Hippo signaling pathway_Homo sapiens_hsa043901.09212041
53Nucleotide excision repair_Homo sapiens_hsa034201.06393743
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05814586
55Ether lipid metabolism_Homo sapiens_hsa005651.04848045
56TGF-beta signaling pathway_Homo sapiens_hsa043501.04220866
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02898419
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02160333
59GnRH signaling pathway_Homo sapiens_hsa049121.00085649
60Non-homologous end-joining_Homo sapiens_hsa034500.98466214
61Choline metabolism in cancer_Homo sapiens_hsa052310.98323502
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96622011
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.96104305
64Fatty acid metabolism_Homo sapiens_hsa012120.95555134
65Spliceosome_Homo sapiens_hsa030400.95502129
66Amphetamine addiction_Homo sapiens_hsa050310.95350842
67Rheumatoid arthritis_Homo sapiens_hsa053230.94680233
68Synaptic vesicle cycle_Homo sapiens_hsa047210.93915740
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93450824
70mRNA surveillance pathway_Homo sapiens_hsa030150.90046067
71Phototransduction_Homo sapiens_hsa047440.89952603
72Gap junction_Homo sapiens_hsa045400.89806429
73Vitamin B6 metabolism_Homo sapiens_hsa007500.88395324
74Arginine and proline metabolism_Homo sapiens_hsa003300.87006836
75Mineral absorption_Homo sapiens_hsa049780.86136242
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83354963
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82930045
78DNA replication_Homo sapiens_hsa030300.82152259
79ErbB signaling pathway_Homo sapiens_hsa040120.82032840
80Calcium signaling pathway_Homo sapiens_hsa040200.80780019
81Sulfur metabolism_Homo sapiens_hsa009200.80653785
82Peroxisome_Homo sapiens_hsa041460.80419169
83Dopaminergic synapse_Homo sapiens_hsa047280.78553794
84Melanoma_Homo sapiens_hsa052180.77264834
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77212601
86MicroRNAs in cancer_Homo sapiens_hsa052060.77152043
87Folate biosynthesis_Homo sapiens_hsa007900.76663577
88Ras signaling pathway_Homo sapiens_hsa040140.76613133
89Oxytocin signaling pathway_Homo sapiens_hsa049210.75962332
90Malaria_Homo sapiens_hsa051440.75634850
91RNA transport_Homo sapiens_hsa030130.75516616
92Caffeine metabolism_Homo sapiens_hsa002320.74972306
93Lysine degradation_Homo sapiens_hsa003100.74734562
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74310195
95Renal cell carcinoma_Homo sapiens_hsa052110.73866295
96Taste transduction_Homo sapiens_hsa047420.72983294
97Chemical carcinogenesis_Homo sapiens_hsa052040.72260480
98Graft-versus-host disease_Homo sapiens_hsa053320.71038577
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70404751
100Glioma_Homo sapiens_hsa052140.69391874
101Regulation of autophagy_Homo sapiens_hsa041400.68442933
102MAPK signaling pathway_Homo sapiens_hsa040100.67378979
103Renin secretion_Homo sapiens_hsa049240.66839869
104FoxO signaling pathway_Homo sapiens_hsa040680.65103791
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63540965
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61973235
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.61899569
108Butanoate metabolism_Homo sapiens_hsa006500.61333105
109p53 signaling pathway_Homo sapiens_hsa041150.61072423
110Estrogen signaling pathway_Homo sapiens_hsa049150.59755925
111Sphingolipid metabolism_Homo sapiens_hsa006000.59331130
112Long-term potentiation_Homo sapiens_hsa047200.58983028
113Rap1 signaling pathway_Homo sapiens_hsa040150.58914385
114Linoleic acid metabolism_Homo sapiens_hsa005910.58603390
115Pyruvate metabolism_Homo sapiens_hsa006200.58557959
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54425585
117Type I diabetes mellitus_Homo sapiens_hsa049400.53716755
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53553301
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53322661
120Prostate cancer_Homo sapiens_hsa052150.53041197
121beta-Alanine metabolism_Homo sapiens_hsa004100.51570732
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.48378899
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47869209
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47585408
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46812847
126Prion diseases_Homo sapiens_hsa050200.45701959
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45524919
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45447344
129Fatty acid elongation_Homo sapiens_hsa000620.45369993
130Prolactin signaling pathway_Homo sapiens_hsa049170.44012957
131Tryptophan metabolism_Homo sapiens_hsa003800.42736583
132Alcoholism_Homo sapiens_hsa050340.41624462
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41017019
134Pancreatic cancer_Homo sapiens_hsa052120.40914226
135Colorectal cancer_Homo sapiens_hsa052100.39703452
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38915708
137Bile secretion_Homo sapiens_hsa049760.37934816
138Huntingtons disease_Homo sapiens_hsa050160.37549733
139Sulfur relay system_Homo sapiens_hsa041220.37258079
140Glycerolipid metabolism_Homo sapiens_hsa005610.37068622
141Fanconi anemia pathway_Homo sapiens_hsa034600.36972623
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35927572
143AMPK signaling pathway_Homo sapiens_hsa041520.32708985
144Thyroid hormone synthesis_Homo sapiens_hsa049180.29514384
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29377109
146Metabolic pathways_Homo sapiens_hsa011000.29108384
147Histidine metabolism_Homo sapiens_hsa003400.28796118

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