NR2E3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of light stimulus (GO:0009583)9.92245165
2positive regulation of guanylate cyclase activity (GO:0031284)9.79359510
3GMP metabolic process (GO:0046037)8.89274433
4regulation of guanylate cyclase activity (GO:0031282)8.85430588
5* visual perception (GO:0007601)8.83012231
6* sensory perception of light stimulus (GO:0050953)8.72687358
7photoreceptor cell differentiation (GO:0046530)7.30041596
8eye photoreceptor cell differentiation (GO:0001754)7.30041596
9* detection of external stimulus (GO:0009581)6.94736239
10cellular response to light stimulus (GO:0071482)6.87066789
11* detection of abiotic stimulus (GO:0009582)6.80797006
12regulation of cGMP metabolic process (GO:0030823)6.37677429
13detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)6.28085708
14* retina development in camera-type eye (GO:0060041)6.11539175
15positive regulation of cGMP biosynthetic process (GO:0030828)5.71159802
16regulation of cGMP biosynthetic process (GO:0030826)5.36436556
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.34259965
18positive regulation of cGMP metabolic process (GO:0030825)5.03239181
19behavioral response to nicotine (GO:0035095)5.03056841
20DNA double-strand break processing (GO:0000729)4.98102296
21positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.93977869
22nonmotile primary cilium assembly (GO:0035058)4.72862536
23cellular response to radiation (GO:0071478)4.39933839
24peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.36875123
25epithelial cilium movement (GO:0003351)4.34895290
26regulation of clathrin-mediated endocytosis (GO:2000369)4.31474210
27regulation of collateral sprouting (GO:0048670)4.21284435
28* sensory perception (GO:0007600)4.13871604
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.09921172
30adaptation of signaling pathway (GO:0023058)4.07436639
31regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.00250182
32meiotic chromosome segregation (GO:0045132)3.96112513
33estrogen biosynthetic process (GO:0006703)3.91648494
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86628278
35regulation of hippo signaling (GO:0035330)3.84692366
36prenylation (GO:0097354)3.83397235
37protein prenylation (GO:0018342)3.83397235
38* response to light stimulus (GO:0009416)3.81837041
39fucose catabolic process (GO:0019317)3.77789527
40L-fucose metabolic process (GO:0042354)3.77789527
41L-fucose catabolic process (GO:0042355)3.77789527
42regulation of voltage-gated calcium channel activity (GO:1901385)3.76458509
43receptor guanylyl cyclase signaling pathway (GO:0007168)3.74535547
44pyrimidine nucleobase catabolic process (GO:0006208)3.73995343
45positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.68879842
46* neuron development (GO:0048666)3.66040607
47cilium movement (GO:0003341)3.61814032
48C4-dicarboxylate transport (GO:0015740)3.61144484
49cilium morphogenesis (GO:0060271)3.60351202
50resolution of meiotic recombination intermediates (GO:0000712)3.58703097
51regulation of cilium movement (GO:0003352)3.58045853
52cell morphogenesis involved in neuron differentiation (GO:0048667)3.57244056
53short-term memory (GO:0007614)3.56855962
54neural tube formation (GO:0001841)3.56552347
55chemosensory behavior (GO:0007635)3.54927357
56retina layer formation (GO:0010842)3.54716767
57detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.54460880
58positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.49235549
59positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.43086815
60retina homeostasis (GO:0001895)3.41745146
61olfactory bulb development (GO:0021772)3.41712295
62negative regulation of translation, ncRNA-mediated (GO:0040033)3.41590218
63regulation of translation, ncRNA-mediated (GO:0045974)3.41590218
64negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.41590218
65protein K11-linked deubiquitination (GO:0035871)3.36724536
66regulation of short-term neuronal synaptic plasticity (GO:0048172)3.35188329
67behavioral response to ethanol (GO:0048149)3.30942126
68cornea development in camera-type eye (GO:0061303)3.29677032
69intraciliary transport (GO:0042073)3.27253050
70positive regulation of ERBB signaling pathway (GO:1901186)3.26984695
71positive regulation of sodium ion transmembrane transport (GO:1902307)3.26443715
72regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.26163905
73regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.26163905
74detection of chemical stimulus involved in sensory perception (GO:0050907)3.25325247
75regulation of penile erection (GO:0060405)3.24857842
76multicellular organism reproduction (GO:0032504)3.18911889
77response to histamine (GO:0034776)3.15085092
78synaptic vesicle maturation (GO:0016188)3.14340335
79positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.14162105
80peptidyl-histidine modification (GO:0018202)3.13770880
81retinoid metabolic process (GO:0001523)3.13436958
82centriole replication (GO:0007099)3.12270638
83negative regulation of receptor-mediated endocytosis (GO:0048261)3.10481563
84protein localization to cilium (GO:0061512)3.10423633
85acrosome reaction (GO:0007340)3.09350286
86cilium organization (GO:0044782)3.07691633
87cilium assembly (GO:0042384)3.02631493
88inner ear receptor stereocilium organization (GO:0060122)3.02004939
89positive regulation of neurotransmitter transport (GO:0051590)3.00587023
90double-strand break repair via nonhomologous end joining (GO:0006303)2.99873143
91non-recombinational repair (GO:0000726)2.99873143
92membrane hyperpolarization (GO:0060081)2.98448929
93GTP biosynthetic process (GO:0006183)2.98443101
94CDP-diacylglycerol biosynthetic process (GO:0016024)2.97691739
95substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.97575647
96substrate-independent telencephalic tangential migration (GO:0021826)2.97575647
97diterpenoid metabolic process (GO:0016101)2.91200374
98negative regulation of astrocyte differentiation (GO:0048712)2.90644072
99protein localization to synapse (GO:0035418)2.90132664
100male meiosis (GO:0007140)2.89655033
101nucleobase catabolic process (GO:0046113)2.87647930
102protein-cofactor linkage (GO:0018065)2.86981810
103motile cilium assembly (GO:0044458)2.86269593
104replication fork processing (GO:0031297)2.85872999
105nephron tubule morphogenesis (GO:0072078)2.81410476
106nephron epithelium morphogenesis (GO:0072088)2.81410476
107limb bud formation (GO:0060174)2.81194321
108DNA integration (GO:0015074)2.80824384
109righting reflex (GO:0060013)2.79608945
110regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.79301792
111negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77348001
112neuronal action potential propagation (GO:0019227)2.76875961
113negative regulation of dendrite development (GO:2000171)2.76720910
114CDP-diacylglycerol metabolic process (GO:0046341)2.74644500
115detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.71526096
116tachykinin receptor signaling pathway (GO:0007217)2.71216788
117histone H3-K9 methylation (GO:0051567)2.69088100
118terpenoid metabolic process (GO:0006721)2.66153350
119glycosphingolipid biosynthetic process (GO:0006688)2.65780261
120recombinational repair (GO:0000725)2.65267297
121cell proliferation in forebrain (GO:0021846)2.64882338
122tongue development (GO:0043586)2.64323272
123axonemal dynein complex assembly (GO:0070286)2.62337172
124regulation of dopamine secretion (GO:0014059)2.62080460
125synapsis (GO:0007129)2.62052921
126lipoprotein transport (GO:0042953)2.61730103
127piRNA metabolic process (GO:0034587)2.59782476
128* response to radiation (GO:0009314)2.59679477
129protein complex biogenesis (GO:0070271)2.58965379
130double-strand break repair via homologous recombination (GO:0000724)2.58937697
131water-soluble vitamin biosynthetic process (GO:0042364)2.58778791
132centriole assembly (GO:0098534)2.56188311
133ventricular system development (GO:0021591)2.55566589
134arachidonic acid secretion (GO:0050482)2.55419445
135icosanoid secretion (GO:0032309)2.55419445
136cell wall macromolecule catabolic process (GO:0016998)2.55035901
137sperm motility (GO:0030317)2.54045787
138otic vesicle formation (GO:0030916)2.53682069
139negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.53598996
140synaptic transmission, cholinergic (GO:0007271)2.52425613
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.51784772
142nucleoside diphosphate phosphorylation (GO:0006165)2.51509963
143sodium ion export (GO:0071436)2.51027988
144cellular potassium ion homeostasis (GO:0030007)2.49394219
145reciprocal DNA recombination (GO:0035825)2.48659972
146reciprocal meiotic recombination (GO:0007131)2.48659972
147cellular component assembly involved in morphogenesis (GO:0010927)2.47351638
148microtubule depolymerization (GO:0007019)2.47080037
149axoneme assembly (GO:0035082)2.46114095
150negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.46056523
151auditory receptor cell stereocilium organization (GO:0060088)2.46051087
152oligosaccharide biosynthetic process (GO:0009312)2.45963839
153behavioral response to cocaine (GO:0048148)2.45756239
154fucosylation (GO:0036065)2.45721266
155dopamine receptor signaling pathway (GO:0007212)2.45607294
156monoubiquitinated protein deubiquitination (GO:0035520)2.45421268
157protein K6-linked ubiquitination (GO:0085020)2.45224835
158positive regulation of oligodendrocyte differentiation (GO:0048714)2.42258993
159positive regulation of cyclase activity (GO:0031281)2.41840700
160artery development (GO:0060840)2.41634530
161phospholipid translocation (GO:0045332)2.41397394
162lipid translocation (GO:0034204)2.41397394
163positive regulation of vesicle fusion (GO:0031340)2.40348411
164synaptic transmission, dopaminergic (GO:0001963)2.40300595
165DNA methylation involved in gamete generation (GO:0043046)2.39374840
166presynaptic membrane assembly (GO:0097105)2.39088381
167startle response (GO:0001964)2.37306016
168glial cell proliferation (GO:0014009)2.37179108
169fatty acid elongation (GO:0030497)2.37076885
170nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.37015673
171UTP biosynthetic process (GO:0006228)2.36906966
172mitochondrial respiratory chain complex assembly (GO:0033108)2.36098301
173negative regulation of cation channel activity (GO:2001258)2.35221695
174synaptic vesicle docking involved in exocytosis (GO:0016081)2.35152290
175response to pheromone (GO:0019236)2.35036187
176negative regulation of calcium ion transmembrane transport (GO:1903170)2.31958093
177negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.31958093
178retinal cone cell development (GO:0046549)18.2158624
179regulation of rhodopsin mediated signaling pathway (GO:0022400)16.6488746
180rhodopsin mediated signaling pathway (GO:0016056)16.0754553
181* photoreceptor cell development (GO:0042461)12.5308927
182* eye photoreceptor cell development (GO:0042462)11.9963255
183photoreceptor cell maintenance (GO:0045494)11.6383595
184detection of light stimulus involved in visual perception (GO:0050908)10.6813866
185detection of light stimulus involved in sensory perception (GO:0050962)10.6813866
186* phototransduction (GO:0007602)10.5268128
187phototransduction, visible light (GO:0007603)10.3972605
188retinal rod cell development (GO:0046548)10.2884079
189protein-chromophore linkage (GO:0018298)10.0494770
190detection of visible light (GO:0009584)10.0257593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.56934388
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.50771798
3ZNF274_21170338_ChIP-Seq_K562_Hela3.56615511
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77989188
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76587086
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61641153
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57750561
8* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.54490860
9* VDR_22108803_ChIP-Seq_LS180_Human2.53146842
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51076996
11GBX2_23144817_ChIP-Seq_PC3_Human2.37832582
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.37075443
13* P300_19829295_ChIP-Seq_ESCs_Human2.30889638
14EWS_26573619_Chip-Seq_HEK293_Human2.29023489
15FUS_26573619_Chip-Seq_HEK293_Human2.25328237
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19795208
17TAF15_26573619_Chip-Seq_HEK293_Human2.18187161
18DROSHA_22980978_ChIP-Seq_HELA_Human2.15842774
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13508197
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10792681
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.00421716
22KDM2B_26808549_Chip-Seq_K562_Human1.99786196
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97166902
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.96659497
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91753115
26ER_23166858_ChIP-Seq_MCF-7_Human1.91530897
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89750213
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89087037
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85647498
30IRF1_19129219_ChIP-ChIP_H3396_Human1.84293141
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.83524527
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.80952923
33SMAD3_21741376_ChIP-Seq_HESCs_Human1.80403557
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.79793859
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.78770711
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78564424
37REST_21632747_ChIP-Seq_MESCs_Mouse1.78179244
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.75836406
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.75310499
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74885350
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73921435
42* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.73398633
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71044685
44CBP_20019798_ChIP-Seq_JUKART_Human1.71044685
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70920782
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.69018559
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66261729
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.65895576
49P53_22127205_ChIP-Seq_FIBROBLAST_Human1.63324708
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.61550735
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60485277
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58955273
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.58181657
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.53574525
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53505077
56AR_19668381_ChIP-Seq_PC3_Human1.53271678
57AR_25329375_ChIP-Seq_VCAP_Human1.53015234
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51874876
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51874876
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.51708094
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51653950
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51144932
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50785675
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49804769
65CTCF_27219007_Chip-Seq_Bcells_Human1.49747775
66* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49599519
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48652911
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45726109
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45721505
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43709001
71BCAT_22108803_ChIP-Seq_LS180_Human1.41997480
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.41870641
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.40524180
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39961106
75TCF4_22108803_ChIP-Seq_LS180_Human1.39582287
76* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36812323
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36017614
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35413801
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33070257
80CREB1_26743006_Chip-Seq_LNCaP_Human1.33020828
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32967418
82AR_21572438_ChIP-Seq_LNCaP_Human1.32901215
83* SMC4_20622854_ChIP-Seq_HELA_Human1.32672665
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31402262
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31298170
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29924700
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28699570
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28292276
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.27263340
90RUNX2_22187159_ChIP-Seq_PCA_Human1.26757107
91WDR5_24793694_ChIP-Seq_LNCAP_Human1.25411575
92* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24571516
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23509663
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23329773
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.23170497
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.23078588
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22300495
98* TBL1_22424771_ChIP-Seq_293T_Human1.19801067
99SMAD4_21799915_ChIP-Seq_A2780_Human1.19404683
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.19291644
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.19088563
102RXR_22108803_ChIP-Seq_LS180_Human1.14840350
103TP53_22573176_ChIP-Seq_HFKS_Human1.14805569
104NANOG_19829295_ChIP-Seq_ESCs_Human1.14151828
105SOX2_19829295_ChIP-Seq_ESCs_Human1.14151828
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.13874654
107TAF2_19829295_ChIP-Seq_ESCs_Human1.13852061
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13332911
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11904124
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11108837
111CBP_21632823_ChIP-Seq_H3396_Human1.11025092
112MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10730538
113P53_22387025_ChIP-Seq_ESCs_Mouse1.09016166
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08740082
115STAT3_23295773_ChIP-Seq_U87_Human1.08430561
116JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08109262
117DPY_21335234_ChIP-Seq_ESCs_Mouse1.06875524
118NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.06629735
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.06255257
120EST1_17652178_ChIP-ChIP_JURKAT_Human1.06091526
121EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05614886
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04770067
123OCT4_19829295_ChIP-Seq_ESCs_Human1.04669693
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.04413699
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04123895
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03695863
127IGF1R_20145208_ChIP-Seq_DFB_Human1.03536779
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03519633
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03362291
130KDM2B_26808549_Chip-Seq_DND41_Human1.03285568
131SA1_27219007_Chip-Seq_Bcells_Human1.02941798
132SMAD4_21741376_ChIP-Seq_EPCs_Human1.02527350
133SMAD4_21741376_ChIP-Seq_HESCs_Human1.02113773
134GATA1_26923725_Chip-Seq_HPCs_Mouse1.01881385
135EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01567635
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00755474
137JUN_21703547_ChIP-Seq_K562_Human1.00128497
138P68_20966046_ChIP-Seq_HELA_Human0.99219652
139CDX2_22108803_ChIP-Seq_LS180_Human0.99151226
140RING1B_27294783_Chip-Seq_ESCs_Mouse0.98371106
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.98292021
142BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97678024
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97557981
144CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97338155
145MYC_18940864_ChIP-ChIP_HL60_Human0.97330533
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97063509
147* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96139017
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95470437
149MYC_19829295_ChIP-Seq_ESCs_Human0.95245375
150TP53_16413492_ChIP-PET_HCT116_Human0.95151480
151* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95073757
152SMAD4_21741376_ChIP-Seq_ESCs_Human0.94397805
153TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94139505
154OCT1_27270436_Chip-Seq_PROSTATE_Human0.93858113
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93732408
156CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93628606
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93496107
158TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93457580
159CRX_20693478_ChIP-Seq_RETINA_Mouse0.93385134
160GABP_17652178_ChIP-ChIP_JURKAT_Human0.93164637
161OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92880733
162SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92685113
163AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92554907
164NCOR_22424771_ChIP-Seq_293T_Human0.92493273
165* EP300_21415370_ChIP-Seq_HL-1_Mouse0.91082562
166CTCF_20526341_ChIP-Seq_ESCs_Human0.90880082
167KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90238478
168GF1_26923725_Chip-Seq_HPCs_Mouse0.89075137
169E2F1_20622854_ChIP-Seq_HELA_Human0.87175768
170GATA1_19941827_ChIP-Seq_MEL_Mouse0.86193647
171POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85489099
172TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85489099
173TCF4_23295773_ChIP-Seq_U87_Human0.85306238
174KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85265922
175LXR_22292898_ChIP-Seq_THP-1_Human0.84575540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005253_abnormal_eye_physiology6.67422384
2* MP0006072_abnormal_retinal_apoptosis5.98816015
3* MP0005195_abnormal_posterior_eye4.11768045
4MP0001324_abnormal_eye_pigmentation3.51298533
5MP0003950_abnormal_plasma_membrane3.36762670
6* MP0005391_vision/eye_phenotype3.31371509
7MP0008877_abnormal_DNA_methylation2.97354717
8MP0002090_abnormal_vision2.95370257
9MP0002229_neurodegeneration2.82398868
10MP0003136_yellow_coat_color2.60621519
11MP0000566_synostosis2.57708991
12MP0002638_abnormal_pupillary_reflex2.57517349
13MP0003183_abnormal_peptide_metabolism2.54440504
14MP0005360_urolithiasis2.45807837
15MP0001529_abnormal_vocalization2.42195541
16MP0005423_abnormal_somatic_nervous2.39483100
17MP0002653_abnormal_ependyma_morphology2.36792892
18MP0003787_abnormal_imprinting2.21866654
19MP0000372_irregular_coat_pigmentation2.17897903
20* MP0002752_abnormal_somatic_nervous2.04321303
21MP0003011_delayed_dark_adaptation10.7336978
22* MP0005551_abnormal_eye_electrophysiolog10.0629549
23MP0002928_abnormal_bile_duct1.93119881
24MP0002102_abnormal_ear_morphology1.89595376
25MP0001764_abnormal_homeostasis1.82304828
26MP0008058_abnormal_DNA_repair1.81999089
27MP0002938_white_spotting1.78268640
28MP0001986_abnormal_taste_sensitivity1.74870504
29MP0009697_abnormal_copulation1.63081422
30MP0003718_maternal_effect1.60714074
31MP0002254_reproductive_system_inflammat1.55196958
32MP0001502_abnormal_circadian_rhythm1.53175742
33MP0000749_muscle_degeneration1.47745714
34MP0006276_abnormal_autonomic_nervous1.46630073
35* MP0002882_abnormal_neuron_morphology1.46065324
36MP0006292_abnormal_olfactory_placode1.45084260
37MP0002736_abnormal_nociception_after1.39038236
38MP0010094_abnormal_chromosome_stability1.34523594
39MP0001485_abnormal_pinna_reflex1.32838935
40MP0002160_abnormal_reproductive_system1.32051492
41MP0005410_abnormal_fertilization1.29884432
42MP0003121_genomic_imprinting1.23736430
43MP0000427_abnormal_hair_cycle1.22453197
44MP0004885_abnormal_endolymph1.21952737
45MP0008875_abnormal_xenobiotic_pharmacok1.18043634
46MP0004019_abnormal_vitamin_homeostasis1.17332637
47MP0004133_heterotaxia1.15865762
48MP0005499_abnormal_olfactory_system1.13517062
49MP0005394_taste/olfaction_phenotype1.13517062
50MP0001970_abnormal_pain_threshold1.07793498
51MP0003698_abnormal_male_reproductive1.06943980
52MP0005377_hearing/vestibular/ear_phenot1.06638340
53MP0003878_abnormal_ear_physiology1.06638340
54MP0005197_abnormal_uvea_morphology1.03272804
55MP0008789_abnormal_olfactory_epithelium1.02392137
56MP0002233_abnormal_nose_morphology1.00543085
57MP0005171_absent_coat_pigmentation1.00398491
58MP0005408_hypopigmentation0.96328637
59MP0001929_abnormal_gametogenesis0.95953083
60MP0002210_abnormal_sex_determination0.95734650
61MP0001984_abnormal_olfaction0.95645925
62MP0004270_analgesia0.93807527
63MP0002282_abnormal_trachea_morphology0.93796711
64MP0004233_abnormal_muscle_weight0.93492140
65MP0005389_reproductive_system_phenotype0.90419836
66MP0000653_abnormal_sex_gland0.88920909
67MP0000538_abnormal_urinary_bladder0.88537893
68MP0002127_abnormal_cardiovascular_syste0.88037377
69MP0001501_abnormal_sleep_pattern0.87821621
70MP0002751_abnormal_autonomic_nervous0.85539275
71MP0005647_abnormal_sex_gland0.85450785
72MP0005187_abnormal_penis_morphology0.84995129
73MP0001486_abnormal_startle_reflex0.83714469
74MP0003938_abnormal_ear_development0.83528117
75MP0008872_abnormal_physiological_respon0.82624206
76MP0001145_abnormal_male_reproductive0.82412166
77MP0002837_dystrophic_cardiac_calcinosis0.81536383
78MP0003634_abnormal_glial_cell0.80962693
79MP0003937_abnormal_limbs/digits/tail_de0.78679207
80MP0000049_abnormal_middle_ear0.78077761
81MP0005646_abnormal_pituitary_gland0.76895975
82MP0001188_hyperpigmentation0.75221642
83MP0002272_abnormal_nervous_system0.74587863
84MP0003755_abnormal_palate_morphology0.74504748
85MP0008004_abnormal_stomach_pH0.68721578
86MP0000465_gastrointestinal_hemorrhage0.68428771
87MP0002332_abnormal_exercise_endurance0.67698903
88MP0004859_abnormal_synaptic_plasticity0.65754106
89MP0001286_abnormal_eye_development0.65467089
90MP0003880_abnormal_central_pattern0.61124251
91MP0005248_abnormal_Harderian_gland0.60045174
92MP0003635_abnormal_synaptic_transmissio0.57984663
93MP0002734_abnormal_mechanical_nocicepti0.57331950
94MP0002064_seizures0.54422798
95MP0003890_abnormal_embryonic-extraembry0.51647470
96MP0010030_abnormal_orbit_morphology0.50569923
97MP0010386_abnormal_urinary_bladder0.50007858
98MP0004742_abnormal_vestibular_system0.46156234
99MP0001963_abnormal_hearing_physiology0.45806249
100MP0002697_abnormal_eye_size0.45705256
101MP0002063_abnormal_learning/memory/cond0.44222217
102MP0002067_abnormal_sensory_capabilities0.42533980
103MP0004782_abnormal_surfactant_physiolog0.42248275
104MP0004924_abnormal_behavior0.41284165
105MP0005386_behavior/neurological_phenoty0.41284165
106MP0000631_abnormal_neuroendocrine_gland0.40166971
107MP0009046_muscle_twitch0.39101784
108MP0009745_abnormal_behavioral_response0.38844690
109MP0002572_abnormal_emotion/affect_behav0.38530083
110MP0002234_abnormal_pharynx_morphology0.38037836
111MP0001968_abnormal_touch/_nociception0.36464696
112MP0005376_homeostasis/metabolism_phenot0.34950423
113MP0001915_intracranial_hemorrhage0.34733047
114MP0003705_abnormal_hypodermis_morpholog0.34475318
115MP0004215_abnormal_myocardial_fiber0.34272168
116MP0001293_anophthalmia0.34269002
117MP0005193_abnormal_anterior_eye0.32900927
118MP0004085_abnormal_heartbeat0.31353218
119MP0009780_abnormal_chondrocyte_physiolo0.30352627
120MP0005076_abnormal_cell_differentiation0.30340574
121MP0005620_abnormal_muscle_contractility0.29884573
122MP0002152_abnormal_brain_morphology0.29506521
123MP0004145_abnormal_muscle_electrophysio0.27705750
124MP0003045_fibrosis0.27400680
125MP0004043_abnormal_pH_regulation0.27330980
126MP0000778_abnormal_nervous_system0.25287953
127MP0002066_abnormal_motor_capabilities/c0.25125982
128MP0008569_lethality_at_weaning0.24616835
129MP0002184_abnormal_innervation0.24613365
130MP0004811_abnormal_neuron_physiology0.24267167
131MP0003632_abnormal_nervous_system0.22951434
132MP0003633_abnormal_nervous_system0.22091574
133MP0005595_abnormal_vascular_smooth0.21737691
134MP0003638_abnormal_response/metabolism_0.20951034
135MP0002092_abnormal_eye_morphology0.18900436
136MP0000026_abnormal_inner_ear0.18410709
137MP0001905_abnormal_dopamine_level0.17386624
138MP0000751_myopathy0.17183250
139MP0004142_abnormal_muscle_tone0.17156032
140MP0001177_atelectasis0.16206470
141MP0003631_nervous_system_phenotype0.15879900
142MP0001346_abnormal_lacrimal_gland0.15412771
143MP0003252_abnormal_bile_duct0.14564530
144MP0003861_abnormal_nervous_system0.14412673
145MP0000955_abnormal_spinal_cord0.13890197
146MP0002557_abnormal_social/conspecific_i0.13460916
147MP0008961_abnormal_basal_metabolism0.12876127
148MP0002909_abnormal_adrenal_gland0.11954053
149MP0001614_abnormal_blood_vessel0.11849805
150MP0001879_abnormal_lymphatic_vessel0.11772750
151MP0010368_abnormal_lymphatic_system0.11597431

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)9.61162577
2* Abnormal rod and cone electroretinograms (HP:0008323)9.58816292
3* Dyschromatopsia (HP:0007641)9.29766089
4Chorioretinal atrophy (HP:0000533)8.93105677
5Central scotoma (HP:0000603)8.33395232
6Abnormality of macular pigmentation (HP:0008002)8.28451506
7Decreased central vision (HP:0007663)7.76959866
8* Pigmentary retinal degeneration (HP:0001146)7.69818139
9Scotoma (HP:0000575)7.38603641
10Attenuation of retinal blood vessels (HP:0007843)7.01579878
11* Abolished electroretinogram (ERG) (HP:0000550)6.94591968
12Severe visual impairment (HP:0001141)6.44740281
13Posterior subcapsular cataract (HP:0007787)6.34117120
14* Photophobia (HP:0000613)5.79533102
15Keratoconus (HP:0000563)5.51716163
16Increased corneal curvature (HP:0100692)5.51716163
17* Type II diabetes mellitus (HP:0005978)5.44002958
18* Macular degeneration (HP:0000608)5.21252436
19Cone-rod dystrophy (HP:0000548)4.90497616
20Constricted visual fields (HP:0001133)4.66943801
21Retinitis pigmentosa (HP:0000510)4.12772614
22Choroideremia (HP:0001139)4.10529403
23Subcapsular cataract (HP:0000523)3.80503485
24Nephronophthisis (HP:0000090)3.54002611
25Chronic hepatic failure (HP:0100626)3.51002055
26Abnormality of the labia minora (HP:0012880)3.50318708
27Decreased electroretinogram (ERG) amplitude (HP:0000654)3.43781864
28Progressive visual loss (HP:0000529)3.30341424
29Abnormality of the renal medulla (HP:0100957)3.18108843
30Bile duct proliferation (HP:0001408)3.17475333
31Abnormal biliary tract physiology (HP:0012439)3.17475333
32Occipital encephalocele (HP:0002085)2.91403078
33Abnormal respiratory epithelium morphology (HP:0012253)2.84277895
34Abnormal respiratory motile cilium morphology (HP:0005938)2.84277895
35Abnormal ciliary motility (HP:0012262)2.83111965
36Type 2 muscle fiber atrophy (HP:0003554)2.66103618
37Abnormal respiratory motile cilium physiology (HP:0012261)2.65971411
38Congenital sensorineural hearing impairment (HP:0008527)2.64968544
39Retinal atrophy (HP:0001105)2.63001930
40* Vitreoretinal degeneration (HP:0000655)2.62390248
41Optic disc pallor (HP:0000543)2.60997505
42Type II lissencephaly (HP:0007260)2.51457119
43Tubular atrophy (HP:0000092)2.50799273
44Atonic seizures (HP:0010819)2.47380981
45Volvulus (HP:0002580)2.47369096
46* Wide nasal bridge (HP:0000431)2.41414104
47Intestinal atresia (HP:0011100)2.41015324
48Abnormality of the aortic arch (HP:0012303)2.40871171
49Hyperglycinuria (HP:0003108)2.39820894
50Absent/shortened dynein arms (HP:0200106)2.37189395
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.37189395
52Lissencephaly (HP:0001339)2.35449110
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.33447262
54Rhinitis (HP:0012384)2.31564328
55Abnormality of the renal cortex (HP:0011035)2.31517901
56Ependymoma (HP:0002888)2.31420435
57Renal dysplasia (HP:0000110)2.31077432
58Hepatocellular necrosis (HP:0001404)2.30489173
59Acute encephalopathy (HP:0006846)2.27424181
60Colon cancer (HP:0003003)2.27268365
61Facial hemangioma (HP:0000329)2.24947881
62Sloping forehead (HP:0000340)2.24874786
63Abnormality of the ileum (HP:0001549)2.21866657
64Tubulointerstitial nephritis (HP:0001970)2.21048490
65Gait imbalance (HP:0002141)2.16760279
66Asplenia (HP:0001746)2.15121587
67Acute necrotizing encephalopathy (HP:0006965)2.14096401
68Congenital primary aphakia (HP:0007707)2.14000629
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.12317695
70Narrow forehead (HP:0000341)2.11180314
71Male pseudohermaphroditism (HP:0000037)2.10131624
72Rib fusion (HP:0000902)2.09521496
73Polar cataract (HP:0010696)2.08438683
74Preaxial hand polydactyly (HP:0001177)2.07068692
75Muscle fiber atrophy (HP:0100295)2.06496632
76Gastrointestinal atresia (HP:0002589)2.06327185
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04884579
78Optic nerve hypoplasia (HP:0000609)2.03164932
79Progressive macrocephaly (HP:0004481)2.02743030
80Aganglionic megacolon (HP:0002251)2.01872631
81Polydipsia (HP:0001959)2.01530719
82Abnormal drinking behavior (HP:0030082)2.01530719
83Congenital stationary night blindness (HP:0007642)13.5684086
84Bony spicule pigmentary retinopathy (HP:0007737)10.5227273
85* Absent rod-and cone-mediated responses on ERG (HP:0007688)10.4931169
86Protruding tongue (HP:0010808)1.97101659
87Gaze-evoked nystagmus (HP:0000640)1.94925936
88Dandy-Walker malformation (HP:0001305)1.94410961
89Hyperglycinemia (HP:0002154)1.92628852
90Astrocytoma (HP:0009592)1.92061767
91Abnormality of the astrocytes (HP:0100707)1.92061767
92Meckel diverticulum (HP:0002245)1.91899856
93Microglossia (HP:0000171)1.91509477
94Abnormality of glycine metabolism (HP:0010895)1.90479812
95Abnormality of serine family amino acid metabolism (HP:0010894)1.90479812
96Multicystic kidney dysplasia (HP:0000003)1.87814290
97Limb dystonia (HP:0002451)1.87432459
98Nephrogenic diabetes insipidus (HP:0009806)1.87419112
99Horizontal nystagmus (HP:0000666)1.87155102
100Abnormality of chromosome stability (HP:0003220)1.86986871
101Renal hypoplasia (HP:0000089)1.86699749
102Adrenal hypoplasia (HP:0000835)1.86104067
103Ectopic kidney (HP:0000086)1.84179031
104Focal seizures (HP:0007359)1.83165861
105Mitochondrial inheritance (HP:0001427)1.83143287
106Lipid accumulation in hepatocytes (HP:0006561)1.81500815
107Severe Myopia (HP:0011003)1.81454294
108Pachygyria (HP:0001302)1.80775443
109Hepatic necrosis (HP:0002605)1.77939796
110Medial flaring of the eyebrow (HP:0010747)1.77755849
111True hermaphroditism (HP:0010459)1.76511168
112Interstitial pulmonary disease (HP:0006530)1.72075078
113Poor coordination (HP:0002370)1.64842649
114Pancreatic fibrosis (HP:0100732)1.58404141
115* Optic atrophy (HP:0000648)1.55069649
116Vaginal atresia (HP:0000148)1.47274147
117Genital tract atresia (HP:0001827)1.40719087
118Cystic liver disease (HP:0006706)1.34170841
119Sclerocornea (HP:0000647)1.32076709
120Pancreatic cysts (HP:0001737)1.27836393
121Dysdiadochokinesis (HP:0002075)1.27211415
122Aplasia/Hypoplasia of the lens (HP:0008063)1.25037431
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.25014985
124Retinal detachment (HP:0000541)1.09079226
125Epileptic encephalopathy (HP:0200134)1.08247087
126Visual hallucinations (HP:0002367)0.99187580
127Abnormality of the fovea (HP:0000493)0.99155313
128Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.97658669
129Furrowed tongue (HP:0000221)0.96904934
130Hypermetropia (HP:0000540)0.96403495
131Hypoplasia of the fovea (HP:0007750)0.95640147
132Aplasia/Hypoplasia of the fovea (HP:0008060)0.95640147
133Chorioretinal coloboma (HP:0000567)0.94442009
134Recurrent sinusitis (HP:0011108)0.94019596
135Astigmatism (HP:0000483)0.93151719
136Left ventricular hypertrophy (HP:0001712)0.92076561
137Febrile seizures (HP:0002373)0.91094252
138Anencephaly (HP:0002323)0.90751924
139Anophthalmia (HP:0000528)0.86916306
140Broad foot (HP:0001769)0.86888082
141Specific learning disability (HP:0001328)0.86273033
142Aplasia/Hypoplasia of the macula (HP:0008059)0.84795808
143Truncal ataxia (HP:0002078)0.83779144
144Progressive cerebellar ataxia (HP:0002073)0.83399549
145Decreased testicular size (HP:0008734)0.80258402
146Macroorchidism (HP:0000053)0.78759705
147Asthma (HP:0002099)0.78470600
148Aplasia/Hypoplasia affecting the retina (HP:0008061)0.78353543
149Aqueductal stenosis (HP:0002410)0.76960989
150Genetic anticipation (HP:0003743)0.75024981
151Prolonged QT interval (HP:0001657)0.74862406
152Abnormality of the lower motor neuron (HP:0002366)0.74410080
153Congenital hepatic fibrosis (HP:0002612)0.72793456
154Molar tooth sign on MRI (HP:0002419)0.69427187
155Abnormality of midbrain morphology (HP:0002418)0.69427187
156Cerebellar dysplasia (HP:0007033)0.68514306
157Septo-optic dysplasia (HP:0100842)0.67335432
158Supranuclear gaze palsy (HP:0000605)0.66125290
159Hypoventilation (HP:0002791)0.65641811
160Lymphopenia (HP:0001888)0.65146210
161Abnormality of the parathyroid morphology (HP:0011766)0.65070600
162Abnormality of the fingertips (HP:0001211)0.64695776
163Postaxial hand polydactyly (HP:0001162)0.64141826
164Oligodactyly (hands) (HP:0001180)0.63277465
165Depression (HP:0000716)0.61277227
166Postaxial foot polydactyly (HP:0001830)0.59755808
167Hypodontia (HP:0000668)0.58381160
168Abnormality of cells of the lymphoid lineage (HP:0012140)0.58201950
169Dental crowding (HP:0000678)0.58033174
170Generalized myoclonic seizures (HP:0002123)0.56825185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.26615725
2WNK34.84622328
3MUSK4.41322003
4PINK12.97900979
5MAP3K102.96682937
6IRAK22.94162961
7WNK42.24701039
8FGFR22.16239384
9TXK2.11327253
10EPHA42.08216703
11ADRBK22.00888010
12GRK110.2684841
13CAMK1G1.94398538
14MAPK131.92418278
15SIK21.87255945
16STK391.81627125
17ADRBK11.81336078
18TNIK1.73322884
19CDK121.71225211
20ERBB31.70279240
21PLK41.69867599
22NUAK11.65657774
23ICK1.65007102
24SGK4941.62727578
25SGK2231.62727578
26MAP4K21.62677876
27HIPK21.62354999
28CAMK1D1.52034255
29MAPK71.50229456
30TRIM281.49779465
31PNCK1.48458372
32BMPR1B1.45162830
33INSRR1.45078736
34CASK1.44398261
35ERBB21.43223794
36BRD41.40208727
37ACVR1B1.37319445
38PAK31.35784772
39MAPK121.35404107
40BCKDK1.32168400
41RPS6KA41.31370790
42WEE11.30764074
43ZAK1.29459894
44DYRK21.26992365
45MAP3K41.24424351
46MARK11.21721723
47PAK61.19709530
48STK381.19685081
49PRKCH1.19006321
50BCR1.13568354
51MKNK21.12961521
52CSNK1D1.09201159
53NEK11.06673807
54TAOK31.06645380
55PRKD31.06076090
56TAF11.03615847
57LATS11.03090817
58STK38L1.01953199
59PTK2B1.00700883
60MARK30.98852771
61MAP3K120.98157836
62MYLK0.95733179
63NEK20.90212867
64SCYL20.87823419
65PRKCZ0.87175335
66SGK20.85850045
67TYRO30.83602777
68DYRK1B0.82041072
69OBSCN0.81865372
70SGK30.80258566
71WNK10.76216529
72GRK50.75884151
73CDK30.75171195
74PIK3CG0.73822094
75CCNB10.72985946
76PLK20.70845704
77SRPK10.70658058
78SIK10.70574920
79DYRK1A0.70441529
80PRKCB0.70012916
81PRKAA10.68546358
82CSNK1G10.68229492
83PHKG10.67975698
84PHKG20.67975698
85AKT30.67556020
86FER0.67467200
87PLK10.67251549
88CAMKK10.65788643
89EPHB20.64417465
90OXSR10.63460134
91RPS6KA30.62257194
92MKNK10.61402280
93PIK3CA0.61360185
94PRKACG0.60758894
95CSNK1G30.60641913
96PRKCE0.59819973
97ALK0.58941888
98STK30.58513391
99CDK90.57893913
100PRKCQ0.52729355
101CAMK2D0.52348025
102CDK50.51293332
103GSK3B0.51009166
104PLK30.50895780
105SGK10.50384961
106CLK10.50236602
107STK110.50069840
108PKN10.48258727
109MAPK140.48200542
110MINK10.48037478
111MAPK90.47833472
112FES0.47721052
113PRKD20.47565570
114CAMK2A0.47341097
115TIE10.46485592
116PRKAA20.46437390
117ATR0.45472613
118EIF2AK30.44616464
119PRKDC0.44200134
120PRKCI0.43463439
121CAMK10.42324636
122MAPKAPK30.42128318
123MAPK100.41548628
124CDK10.40326624
125CAMK40.40248389
126TTK0.40161637
127MAP2K40.40074320
128MAP2K70.40006478
129LIMK10.37669394
130PRPF4B0.37601039
131ROCK10.37432933
132FRK0.37393454
133AKT20.37142151
134CDC70.36699790
135PRKG10.35864185
136GSK3A0.35703240
137RET0.35226574
138CSNK1E0.34656702
139DYRK30.34309607
140PRKD10.33518069
141PRKACB0.33337581
142NTRK20.32323142
143PRKACA0.31990687
144MAP3K70.31811209
145VRK20.30529072
146CDC42BPA0.30521830
147BRSK20.29772429
148NTRK30.29010088
149PDGFRB0.28976481
150IGF1R0.28298778
151CSNK1G20.28090609
152MAPK80.26999043
153TGFBR10.26997729
154CSNK1A1L0.26855492
155PRKCG0.26710739
156CHEK20.25823406
157CHEK10.25718490
158IRAK10.25172014
159NLK0.24814921
160FYN0.23937888
161PRKCA0.23262797
162ATM0.22513544
163RPS6KA50.22490202

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.63115700
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58729091
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37032397
4Propanoate metabolism_Homo sapiens_hsa006402.25576291
5Fanconi anemia pathway_Homo sapiens_hsa034602.25005782
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05561469
7Phototransduction_Homo sapiens_hsa0474415.7777382
8Basal transcription factors_Homo sapiens_hsa030221.91111299
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90410131
10Linoleic acid metabolism_Homo sapiens_hsa005911.83418262
11Homologous recombination_Homo sapiens_hsa034401.79862668
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75880041
13RNA degradation_Homo sapiens_hsa030181.74269841
14Butanoate metabolism_Homo sapiens_hsa006501.72163357
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66352736
16Synaptic vesicle cycle_Homo sapiens_hsa047211.64060157
17Parkinsons disease_Homo sapiens_hsa050121.60693300
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59455459
19Oxidative phosphorylation_Homo sapiens_hsa001901.54800061
20Olfactory transduction_Homo sapiens_hsa047401.53207806
21Protein export_Homo sapiens_hsa030601.50883606
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47754199
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35286255
24Hedgehog signaling pathway_Homo sapiens_hsa043401.32974835
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28285840
26GABAergic synapse_Homo sapiens_hsa047271.27630051
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22699514
28Huntingtons disease_Homo sapiens_hsa050161.21244250
29Mismatch repair_Homo sapiens_hsa034301.19991185
30Ether lipid metabolism_Homo sapiens_hsa005651.17292599
31Selenocompound metabolism_Homo sapiens_hsa004501.13521899
32Steroid biosynthesis_Homo sapiens_hsa001001.11710859
33Vitamin B6 metabolism_Homo sapiens_hsa007501.11612984
34Chemical carcinogenesis_Homo sapiens_hsa052041.11590245
35RNA polymerase_Homo sapiens_hsa030201.11057771
36Base excision repair_Homo sapiens_hsa034101.08806722
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07000820
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06466157
39One carbon pool by folate_Homo sapiens_hsa006701.01698507
40Fat digestion and absorption_Homo sapiens_hsa049751.01324688
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00039728
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97768632
43Tryptophan metabolism_Homo sapiens_hsa003800.97176383
44Fatty acid degradation_Homo sapiens_hsa000710.97081096
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95933401
46Caffeine metabolism_Homo sapiens_hsa002320.95326155
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93350354
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.92269195
49Cholinergic synapse_Homo sapiens_hsa047250.92104322
50Vitamin digestion and absorption_Homo sapiens_hsa049770.88904140
51RNA transport_Homo sapiens_hsa030130.87008468
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86938134
53Glutamatergic synapse_Homo sapiens_hsa047240.86901083
54beta-Alanine metabolism_Homo sapiens_hsa004100.86726010
55Dopaminergic synapse_Homo sapiens_hsa047280.85140375
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85134082
57Circadian entrainment_Homo sapiens_hsa047130.84859909
58Proteasome_Homo sapiens_hsa030500.83687948
59Morphine addiction_Homo sapiens_hsa050320.82284231
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80715515
61Alzheimers disease_Homo sapiens_hsa050100.80561228
62Circadian rhythm_Homo sapiens_hsa047100.79993176
63Retinol metabolism_Homo sapiens_hsa008300.79922109
64Nucleotide excision repair_Homo sapiens_hsa034200.79425621
65Nitrogen metabolism_Homo sapiens_hsa009100.74531803
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74083382
67Peroxisome_Homo sapiens_hsa041460.73337549
68Fatty acid metabolism_Homo sapiens_hsa012120.72232910
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71981090
70Pyrimidine metabolism_Homo sapiens_hsa002400.71944818
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.71427126
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68365794
73Serotonergic synapse_Homo sapiens_hsa047260.66118439
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65840213
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.64776661
76Metabolic pathways_Homo sapiens_hsa011000.63030803
77Histidine metabolism_Homo sapiens_hsa003400.59888822
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57056673
79Pyruvate metabolism_Homo sapiens_hsa006200.56721988
80Regulation of autophagy_Homo sapiens_hsa041400.56653374
81Insulin secretion_Homo sapiens_hsa049110.56214445
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55576308
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55125069
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55051809
85Arachidonic acid metabolism_Homo sapiens_hsa005900.54715189
86Axon guidance_Homo sapiens_hsa043600.53278051
87ABC transporters_Homo sapiens_hsa020100.52811908
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50406447
89Gap junction_Homo sapiens_hsa045400.50127401
90Basal cell carcinoma_Homo sapiens_hsa052170.49843403
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45662849
92Purine metabolism_Homo sapiens_hsa002300.44848494
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44063038
94Nicotine addiction_Homo sapiens_hsa050330.43542194
95mTOR signaling pathway_Homo sapiens_hsa041500.42869318
96cAMP signaling pathway_Homo sapiens_hsa040240.40379440
97Oxytocin signaling pathway_Homo sapiens_hsa049210.39592318
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37845138
99Gastric acid secretion_Homo sapiens_hsa049710.37353199
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37351833
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37187578
102Salivary secretion_Homo sapiens_hsa049700.34669011
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34231318
104Dilated cardiomyopathy_Homo sapiens_hsa054140.34077800
105Fatty acid elongation_Homo sapiens_hsa000620.33814581
106Cardiac muscle contraction_Homo sapiens_hsa042600.32950814
107Renin secretion_Homo sapiens_hsa049240.31690976
108Lysine degradation_Homo sapiens_hsa003100.29338448
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.29332414
110Glycerolipid metabolism_Homo sapiens_hsa005610.28656241
111Arginine biosynthesis_Homo sapiens_hsa002200.28370928
112Inositol phosphate metabolism_Homo sapiens_hsa005620.27707140
113Type II diabetes mellitus_Homo sapiens_hsa049300.27689593
114Cocaine addiction_Homo sapiens_hsa050300.27527284
115Long-term potentiation_Homo sapiens_hsa047200.26446302
116Glucagon signaling pathway_Homo sapiens_hsa049220.25249794
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.24416508
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24371740
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.24316718
120Fructose and mannose metabolism_Homo sapiens_hsa000510.24127019
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23659246
122Alcoholism_Homo sapiens_hsa050340.22865280
123Bile secretion_Homo sapiens_hsa049760.22858959
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21209963
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20437596
126HIF-1 signaling pathway_Homo sapiens_hsa040660.19761545
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.19665296
128Amphetamine addiction_Homo sapiens_hsa050310.19604680
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19440486
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19025119
131Chemokine signaling pathway_Homo sapiens_hsa040620.18555252
132AMPK signaling pathway_Homo sapiens_hsa041520.17682558
133mRNA surveillance pathway_Homo sapiens_hsa030150.17431262
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17367051
135Calcium signaling pathway_Homo sapiens_hsa040200.16469702
136Tight junction_Homo sapiens_hsa045300.15079245
137Ras signaling pathway_Homo sapiens_hsa040140.14969706
138Thyroid hormone synthesis_Homo sapiens_hsa049180.14538641
139Biosynthesis of amino acids_Homo sapiens_hsa012300.13772562
140GnRH signaling pathway_Homo sapiens_hsa049120.13256100
141Insulin resistance_Homo sapiens_hsa049310.13129992
142Glioma_Homo sapiens_hsa052140.10980623
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10228408
144Galactose metabolism_Homo sapiens_hsa000520.10085422
145Pancreatic secretion_Homo sapiens_hsa049720.09631501
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09625753
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.09042649
148Renal cell carcinoma_Homo sapiens_hsa052110.08799367
149MAPK signaling pathway_Homo sapiens_hsa040100.08578677
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.08514650
151Choline metabolism in cancer_Homo sapiens_hsa052310.08342827
152Wnt signaling pathway_Homo sapiens_hsa043100.07331885
153Mineral absorption_Homo sapiens_hsa049780.07217298
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.07115776
155Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06443446
156Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06410461
157Hippo signaling pathway_Homo sapiens_hsa043900.06392671
1582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.06037488
159Fatty acid biosynthesis_Homo sapiens_hsa000610.06004319
160Notch signaling pathway_Homo sapiens_hsa043300.05823875
161Ovarian steroidogenesis_Homo sapiens_hsa049130.05580615
162Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05544706
163Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05514740
164Taste transduction_Homo sapiens_hsa047420.04456977
165Endometrial cancer_Homo sapiens_hsa052130.04023990
166Oocyte meiosis_Homo sapiens_hsa041140.03905705

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »