NR2F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.83100142
2neuron cell-cell adhesion (GO:0007158)5.80223426
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15015315
4protein localization to synapse (GO:0035418)4.96215776
5neuron recognition (GO:0008038)4.75979612
6dendritic spine morphogenesis (GO:0060997)4.67969653
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.61779166
8presynaptic membrane assembly (GO:0097105)4.47534161
9postsynaptic membrane organization (GO:0001941)4.47302882
10layer formation in cerebral cortex (GO:0021819)4.44688153
11regulation of glutamate receptor signaling pathway (GO:1900449)4.39595119
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.35831330
13axonal fasciculation (GO:0007413)4.28915220
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.28029139
15locomotory exploration behavior (GO:0035641)4.12995028
16glutamate receptor signaling pathway (GO:0007215)4.09651955
17presynaptic membrane organization (GO:0097090)4.04151642
18positive regulation of synapse assembly (GO:0051965)4.00869356
19positive regulation of synapse maturation (GO:0090129)3.86675531
20generation of neurons (GO:0048699)3.86254395
21fat-soluble vitamin biosynthetic process (GO:0042362)3.81524093
22exploration behavior (GO:0035640)3.77766123
23synaptic vesicle exocytosis (GO:0016079)3.76684687
24central nervous system projection neuron axonogenesis (GO:0021952)3.72907927
25neuron projection extension involved in neuron projection guidance (GO:1902284)3.70994450
26axon extension involved in axon guidance (GO:0048846)3.70994450
27cell migration in hindbrain (GO:0021535)3.70366399
28planar cell polarity pathway involved in neural tube closure (GO:0090179)3.70310573
29retinal ganglion cell axon guidance (GO:0031290)3.67511173
30pyrimidine nucleobase catabolic process (GO:0006208)3.63398394
31regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.62110612
32cerebral cortex radially oriented cell migration (GO:0021799)3.59560381
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.59300174
34metanephric mesenchyme development (GO:0072075)3.57946840
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.55479518
36synaptic transmission, glutamatergic (GO:0035249)3.53936414
37neuronal action potential propagation (GO:0019227)3.48627256
38kidney mesenchyme development (GO:0072074)3.48087693
39limb bud formation (GO:0060174)3.48087221
40regulation of dendritic spine morphogenesis (GO:0061001)3.47433723
41gamma-aminobutyric acid transport (GO:0015812)3.46030660
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45532655
43gastrulation with mouth forming second (GO:0001702)3.44842139
44transmission of nerve impulse (GO:0019226)3.44537178
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44264682
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.34021534
47regulation of synaptic vesicle exocytosis (GO:2000300)3.31215403
48dendrite morphogenesis (GO:0048813)3.30505035
49lateral sprouting from an epithelium (GO:0060601)3.29979135
50regulation of synapse assembly (GO:0051963)3.29255327
51spinal cord development (GO:0021510)3.29136206
52auditory behavior (GO:0031223)3.28873801
53cranial nerve morphogenesis (GO:0021602)3.28029104
54glutamate secretion (GO:0014047)3.27421992
55negative regulation of catenin import into nucleus (GO:0035414)3.26685588
56regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.26677338
57neurotransmitter-gated ion channel clustering (GO:0072578)3.25133072
58positive regulation of dendritic spine development (GO:0060999)3.24838751
59startle response (GO:0001964)3.24417541
60neuronal stem cell maintenance (GO:0097150)3.22274013
61neuron-neuron synaptic transmission (GO:0007270)3.21461496
62synapse assembly (GO:0007416)3.21102501
63cochlea morphogenesis (GO:0090103)3.19684441
64regulation of neuronal synaptic plasticity (GO:0048168)3.19266789
65regulation of dendritic spine development (GO:0060998)3.18091413
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17395122
67negative regulation of axon guidance (GO:1902668)3.17395035
68cerebellar granule cell differentiation (GO:0021707)3.17078909
69positive regulation of dendritic spine morphogenesis (GO:0061003)3.15776368
70proline transport (GO:0015824)3.15526337
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14811432
72synaptic vesicle maturation (GO:0016188)3.14510468
73forebrain neuron differentiation (GO:0021879)3.14412337
74positive regulation of membrane potential (GO:0045838)3.14160910
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13528829
76limb development (GO:0060173)3.13514325
77appendage development (GO:0048736)3.13514325
78synapse organization (GO:0050808)3.13497764
79regulation of synapse maturation (GO:0090128)3.11821857
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11473686
81negative regulation of oligodendrocyte differentiation (GO:0048715)3.11276505
82neurotransmitter secretion (GO:0007269)3.09992944
83neuron fate determination (GO:0048664)3.09914242
84G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.07152519
85pattern specification involved in kidney development (GO:0061004)3.07113454
86regulation of synapse organization (GO:0050807)3.06371213
87nucleobase catabolic process (GO:0046113)3.05325042
88regulation of axon guidance (GO:1902667)3.04295349
89regulation of postsynaptic membrane potential (GO:0060078)2.98489617
90central nervous system neuron axonogenesis (GO:0021955)2.96440761
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95171748
92cerebral cortex neuron differentiation (GO:0021895)2.94041854
93innervation (GO:0060384)2.93324973
94cochlea development (GO:0090102)2.93152949
95regulation of respiratory system process (GO:0044065)2.92585711
96long-term memory (GO:0007616)2.91912525
97neuron projection extension (GO:1990138)2.87411744
98negative regulation of axon extension (GO:0030517)2.87219107
99somite development (GO:0061053)2.86166466
100lens fiber cell development (GO:0070307)2.86120711
101convergent extension (GO:0060026)2.84302827
102mechanosensory behavior (GO:0007638)2.82199678
103Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.80994418
104positive regulation of gastrulation (GO:2000543)2.80757018
105segment specification (GO:0007379)2.80722762
106regulation of synapse structural plasticity (GO:0051823)2.79243438
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79149701
108long-term synaptic potentiation (GO:0060291)2.77950582
109camera-type eye morphogenesis (GO:0048593)2.77629830
110regulation of synaptic vesicle transport (GO:1902803)2.77448934
111response to auditory stimulus (GO:0010996)2.74759756
112hippocampus development (GO:0021766)2.74323128
113axon extension (GO:0048675)2.73329153
114dendritic spine organization (GO:0097061)2.72950175
115regulation of synaptic transmission, glutamatergic (GO:0051966)2.71530074
116learning (GO:0007612)2.70381442
117regulation of axon extension involved in axon guidance (GO:0048841)2.69886814
118regulation of establishment of planar polarity (GO:0090175)2.69023709
119cilium movement (GO:0003341)2.68584224
120regulation of cAMP-dependent protein kinase activity (GO:2000479)2.68452104
121ectoderm development (GO:0007398)2.68323636
122intraspecies interaction between organisms (GO:0051703)2.67957975
123social behavior (GO:0035176)2.67957975
124proximal/distal pattern formation (GO:0009954)2.66636265
125synaptic vesicle docking involved in exocytosis (GO:0016081)2.66379860
126central nervous system myelination (GO:0022010)2.65757757
127axon ensheathment in central nervous system (GO:0032291)2.65757757
128negative regulation of microtubule polymerization (GO:0031115)2.65417289
129regulation of respiratory gaseous exchange (GO:0043576)2.63298196
130negative regulation of axon extension involved in axon guidance (GO:0048843)2.62958519
131regulation of synaptic plasticity (GO:0048167)2.62228888
132negative regulation of astrocyte differentiation (GO:0048712)2.61301888
133neuron remodeling (GO:0016322)2.60783294
134non-canonical Wnt signaling pathway (GO:0035567)2.58560023
135regulation of dendrite morphogenesis (GO:0048814)2.58144859
136neurotransmitter transport (GO:0006836)2.57826860
137axonogenesis (GO:0007409)2.57670063
138negative regulation of axonogenesis (GO:0050771)2.57632046
139neuron fate specification (GO:0048665)2.54854314
140establishment of mitochondrion localization (GO:0051654)2.53659496
141head development (GO:0060322)2.52727725
142regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50420936
143peripheral nervous system neuron development (GO:0048935)2.50307648
144short-term memory (GO:0007614)2.48496999
145establishment of tissue polarity (GO:0007164)2.47688074
146establishment of planar polarity (GO:0001736)2.47688074
147negative regulation of glial cell differentiation (GO:0045686)2.45059447
148glomerulus development (GO:0032835)2.40981921
149neurogenesis (GO:0022008)2.38299496
150nonmotile primary cilium assembly (GO:0035058)2.36345002
151midbrain development (GO:0030901)2.35029240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06346688
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.81218990
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.51941046
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15779812
5GBX2_23144817_ChIP-Seq_PC3_Human3.14378044
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09214216
7* EZH2_27304074_Chip-Seq_ESCs_Mouse3.04941294
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87865363
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87865363
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.84244258
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.80836747
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.77635978
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.68723591
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67122230
15* EZH2_27294783_Chip-Seq_ESCs_Mouse2.41808498
16* CBX2_27304074_Chip-Seq_ESCs_Mouse2.35231081
17* RNF2_27304074_Chip-Seq_ESCs_Mouse2.34454258
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30848628
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28505884
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18362931
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17633536
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.14681770
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10435961
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10417067
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92008100
26* REST_21632747_ChIP-Seq_MESCs_Mouse1.91714395
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.90979847
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88518541
29TAF15_26573619_Chip-Seq_HEK293_Human1.86183082
30AR_21572438_ChIP-Seq_LNCaP_Human1.85682183
31ZNF274_21170338_ChIP-Seq_K562_Hela1.85446768
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81185615
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.79183690
34RNF2_27304074_Chip-Seq_NSC_Mouse1.75038571
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73481768
36* RING1B_27294783_Chip-Seq_ESCs_Mouse1.69838209
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67551692
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63672192
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.60913312
40* REST_18959480_ChIP-ChIP_MESCs_Mouse1.60596646
41* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59471812
42DROSHA_22980978_ChIP-Seq_HELA_Human1.53662494
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.53556531
44P300_19829295_ChIP-Seq_ESCs_Human1.47006044
45* RING1B_27294783_Chip-Seq_NPCs_Mouse1.44232876
46OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.42605046
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.41305782
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39438849
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38705378
50SMAD4_21799915_ChIP-Seq_A2780_Human1.38686628
51* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38625554
52FUS_26573619_Chip-Seq_HEK293_Human1.36582547
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33800338
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30571822
55* TP53_20018659_ChIP-ChIP_R1E_Mouse1.27098474
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27085028
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26993933
58* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25271707
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.24103200
60* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22992976
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20720425
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.20373922
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19641075
64* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18990735
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17089117
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15616086
67AR_25329375_ChIP-Seq_VCAP_Human1.15347722
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14933175
69* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14272168
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13834246
71* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10598711
72* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09292864
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.09065269
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.08980374
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08347711
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07006660
77* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05453772
78* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05453772
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04761289
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04614199
81TP53_18474530_ChIP-ChIP_U2OS_Human1.02836908
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01679800
83ER_23166858_ChIP-Seq_MCF-7_Human1.01656608
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01501404
85* SOX9_26525672_Chip-Seq_HEART_Mouse1.01251233
86* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01174625
87AHR_22903824_ChIP-Seq_MCF-7_Human0.98514167
88NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98353701
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98023247
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97300933
91* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97300229
92AR_19668381_ChIP-Seq_PC3_Human0.97295710
93KDM2B_26808549_Chip-Seq_K562_Human0.96300113
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.96208646
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96011387
96TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95244110
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95015900
98YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94470108
99TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94172735
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93948930
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93522448
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93314418
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93266795
104RUNX2_22187159_ChIP-Seq_PCA_Human0.92890527
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92361233
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92197733
107JUN_21703547_ChIP-Seq_K562_Human0.90887228
108VDR_22108803_ChIP-Seq_LS180_Human0.89564729
109* STAT3_23295773_ChIP-Seq_U87_Human0.89485465
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89110528
111* ISL1_27105846_Chip-Seq_CPCs_Mouse0.89011746
112* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88946712
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88439827
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.88245351
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.87312290
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.86586531
117* KDM2B_26808549_Chip-Seq_REH_Human0.85919437
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85762047
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85504971
120IGF1R_20145208_ChIP-Seq_DFB_Human0.85453131
121SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85333555
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.85280536
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84309388
124POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81871261

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.72440514
2MP0004859_abnormal_synaptic_plasticity4.29395626
3MP0000566_synostosis3.22167705
4MP0010030_abnormal_orbit_morphology3.18500510
5MP0003635_abnormal_synaptic_transmissio3.16439850
6MP0004270_analgesia2.95825574
7* MP0000778_abnormal_nervous_system2.91527424
8MP0003303_peritoneal_inflammation2.70296970
9MP0009745_abnormal_behavioral_response2.60041416
10MP0005423_abnormal_somatic_nervous2.57182886
11MP0002063_abnormal_learning/memory/cond2.54322033
12MP0003646_muscle_fatigue2.44516762
13MP0001968_abnormal_touch/_nociception2.42302660
14MP0002064_seizures2.30319147
15MP0002572_abnormal_emotion/affect_behav2.17028565
16MP0001486_abnormal_startle_reflex2.15774889
17MP0009046_muscle_twitch2.12282185
18MP0002734_abnormal_mechanical_nocicepti2.07289853
19MP0006276_abnormal_autonomic_nervous2.05910777
20MP0002102_abnormal_ear_morphology2.05141248
21MP0001346_abnormal_lacrimal_gland1.95782771
22MP0004885_abnormal_endolymph1.91717204
23MP0005503_abnormal_tendon_morphology1.90537883
24MP0002272_abnormal_nervous_system1.90327219
25MP0002184_abnormal_innervation1.88289807
26MP0002736_abnormal_nociception_after1.81474047
27MP0000049_abnormal_middle_ear1.79252290
28MP0006292_abnormal_olfactory_placode1.72529900
29MP0002067_abnormal_sensory_capabilities1.70595112
30MP0002735_abnormal_chemical_nociception1.66769365
31MP0002733_abnormal_thermal_nociception1.65476537
32MP0003283_abnormal_digestive_organ1.65394141
33MP0002557_abnormal_social/conspecific_i1.65091850
34MP0001188_hyperpigmentation1.63481081
35MP0003136_yellow_coat_color1.62733852
36MP0004133_heterotaxia1.59831734
37MP0001440_abnormal_grooming_behavior1.58841994
38MP0004742_abnormal_vestibular_system1.57814984
39MP0001485_abnormal_pinna_reflex1.53842733
40MP0003329_amyloid_beta_deposits1.52768503
41* MP0003938_abnormal_ear_development1.52327648
42MP0009053_abnormal_anal_canal1.50160471
43MP0001299_abnormal_eye_distance/1.49546319
44MP0000631_abnormal_neuroendocrine_gland1.48463284
45MP0004858_abnormal_nervous_system1.48430969
46MP0003119_abnormal_digestive_system1.44789361
47MP0002822_catalepsy1.43573750
48MP0009379_abnormal_foot_pigmentation1.43472916
49MP0002938_white_spotting1.41522375
50MP0001970_abnormal_pain_threshold1.41516690
51* MP0000026_abnormal_inner_ear1.39779539
52MP0002653_abnormal_ependyma_morphology1.36334594
53* MP0002152_abnormal_brain_morphology1.36147890
54MP0000955_abnormal_spinal_cord1.35917731
55MP0002249_abnormal_larynx_morphology1.35741466
56* MP0002882_abnormal_neuron_morphology1.35722705
57MP0000537_abnormal_urethra_morphology1.35381847
58MP0004811_abnormal_neuron_physiology1.32597485
59MP0005386_behavior/neurological_phenoty1.32178530
60MP0004924_abnormal_behavior1.32178530
61MP0001501_abnormal_sleep_pattern1.30769261
62* MP0003861_abnormal_nervous_system1.28315934
63MP0003385_abnormal_body_wall1.26531786
64MP0009780_abnormal_chondrocyte_physiolo1.25177091
65MP0002066_abnormal_motor_capabilities/c1.23298054
66MP0003879_abnormal_hair_cell1.22227037
67MP0008569_lethality_at_weaning1.21729312
68* MP0001963_abnormal_hearing_physiology1.21373663
69MP0002932_abnormal_joint_morphology1.21244041
70MP0003122_maternal_imprinting1.20510394
71MP0001177_atelectasis1.18231546
72MP0001905_abnormal_dopamine_level1.15054056
73MP0001984_abnormal_olfaction1.14861862
74MP0008438_abnormal_cutaneous_collagen1.13129534
75* MP0002697_abnormal_eye_size1.12904048
76MP0005394_taste/olfaction_phenotype1.12478613
77MP0005499_abnormal_olfactory_system1.12478613
78MP0004142_abnormal_muscle_tone1.12219633
79MP0002638_abnormal_pupillary_reflex1.11367842
80* MP0001286_abnormal_eye_development1.11318101
81MP0000428_abnormal_craniofacial_morphol1.11137758
82MP0005623_abnormal_meninges_morphology1.07356513
83MP0001958_emphysema1.06878092
84MP0003942_abnormal_urinary_system1.06733386
85MP0003935_abnormal_craniofacial_develop1.04598102
86MP0008789_abnormal_olfactory_epithelium1.04447690
87* MP0002752_abnormal_somatic_nervous1.02905930
88MP0001879_abnormal_lymphatic_vessel1.02203804
89MP0003121_genomic_imprinting1.02052265
90MP0009278_abnormal_bone_marrow1.01512816
91MP0001529_abnormal_vocalization0.99475736
92MP0002282_abnormal_trachea_morphology0.98945532
93MP0005248_abnormal_Harderian_gland0.96983799
94MP0005508_abnormal_skeleton_morphology0.96894986
95MP0001293_anophthalmia0.96765399
96MP0000762_abnormal_tongue_morphology0.95576136
97MP0001502_abnormal_circadian_rhythm0.94995944
98MP0009250_abnormal_appendicular_skeleto0.91542203
99MP0005645_abnormal_hypothalamus_physiol0.90197029
100MP0003115_abnormal_respiratory_system0.89599433
101MP0005646_abnormal_pituitary_gland0.88243139
102MP0003634_abnormal_glial_cell0.88240403
103MP0005257_abnormal_intraocular_pressure0.86952093
104MP0004145_abnormal_muscle_electrophysio0.86399954
105MP0002114_abnormal_axial_skeleton0.86251670
106MP0002116_abnormal_craniofacial_bone0.83636622
107MP0006072_abnormal_retinal_apoptosis0.83258254
108MP0003755_abnormal_palate_morphology0.83040646
109MP0002909_abnormal_adrenal_gland0.82844962
110MP0002751_abnormal_autonomic_nervous0.82665218
111MP0002234_abnormal_pharynx_morphology0.81911827
112MP0000538_abnormal_urinary_bladder0.81684519
113MP0002233_abnormal_nose_morphology0.81546199
114MP0005409_darkened_coat_color0.80537193
115MP0000534_abnormal_ureter_morphology0.79528400
116MP0005187_abnormal_penis_morphology0.79416185
117* MP0002081_perinatal_lethality0.79167856
118MP0005551_abnormal_eye_electrophysiolog0.79000485
119MP0003937_abnormal_limbs/digits/tail_de0.77096517
120MP0005171_absent_coat_pigmentation0.76204239
121MP0001943_abnormal_respiration0.74240867
122MP0000751_myopathy0.74158683
123MP0001664_abnormal_digestion0.73199345
124MP0001270_distended_abdomen0.72167093
125MP0002837_dystrophic_cardiac_calcinosis0.70514472
126MP0003137_abnormal_impulse_conducting0.70046995

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.25683079
2Myokymia (HP:0002411)4.92608843
3Hyperventilation (HP:0002883)3.67564044
4Focal seizures (HP:0007359)3.66714191
5Broad-based gait (HP:0002136)3.65882075
6Short 4th metacarpal (HP:0010044)3.38712164
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.38712164
8Rectal prolapse (HP:0002035)3.36302670
9Epileptic encephalopathy (HP:0200134)3.32696895
10Germ cell neoplasia (HP:0100728)3.20709695
11Abnormality of the 4th metacarpal (HP:0010012)3.15899257
12Atonic seizures (HP:0010819)3.14142159
13Febrile seizures (HP:0002373)3.12301255
14Morphological abnormality of the middle ear (HP:0008609)3.07259626
15Megalencephaly (HP:0001355)3.01319053
16Amblyopia (HP:0000646)2.96693036
17Excessive salivation (HP:0003781)2.95561915
18Drooling (HP:0002307)2.95561915
19Gastrointestinal infarctions (HP:0005244)2.92951197
20Coronal craniosynostosis (HP:0004440)2.91444867
21Visual hallucinations (HP:0002367)2.86548786
22Hemiparesis (HP:0001269)2.76878314
23Hypochromic anemia (HP:0001931)2.70336077
24Abnormality of nail color (HP:0100643)2.63453244
25Esophageal neoplasm (HP:0100751)2.59977617
26Neoplasm of head and neck (HP:0012288)2.59977617
27Progressive cerebellar ataxia (HP:0002073)2.59242663
28Partial duplication of the phalanx of hand (HP:0009999)2.57507501
29Partial duplication of thumb phalanx (HP:0009944)2.55559822
30Abnormal ciliary motility (HP:0012262)2.55354244
31Septo-optic dysplasia (HP:0100842)2.53004166
32Absence seizures (HP:0002121)2.51947464
33Turricephaly (HP:0000262)2.48330392
34Absent speech (HP:0001344)2.47621343
35Midline defect of the nose (HP:0004122)2.46781132
36Generalized tonic-clonic seizures (HP:0002069)2.46233599
37Stereotypic behavior (HP:0000733)2.45220082
38Testicular neoplasm (HP:0010788)2.37228447
39Wide anterior fontanel (HP:0000260)2.36207494
40Poor eye contact (HP:0000817)2.35919067
41Broad metatarsal (HP:0001783)2.35546714
42Shallow orbits (HP:0000586)2.32257983
43Ankle clonus (HP:0011448)2.31788591
44Cutaneous syndactyly (HP:0012725)2.31318811
45Abnormal respiratory motile cilium physiology (HP:0012261)2.30638224
46Limb dystonia (HP:0002451)2.29214765
47Truncal ataxia (HP:0002078)2.27959704
48Split foot (HP:0001839)2.26389717
49Dialeptic seizures (HP:0011146)2.26039510
50Trigonocephaly (HP:0000243)2.20029693
51Abnormality of the diencephalon (HP:0010662)2.17097389
52Shawl scrotum (HP:0000049)2.16877227
53Sporadic (HP:0003745)2.15635490
54Calcaneovalgus deformity (HP:0001848)2.14369566
55High anterior hairline (HP:0009890)2.11323304
56Abnormality of binocular vision (HP:0011514)2.08498454
57Diplopia (HP:0000651)2.08498454
58Hamartoma (HP:0010566)2.08147243
59Partial agenesis of the corpus callosum (HP:0001338)2.07603173
60Neonatal short-limb short stature (HP:0008921)2.07580204
61Cerebral inclusion bodies (HP:0100314)2.07122827
62Exotropia (HP:0000577)2.06362124
63Biliary tract neoplasm (HP:0100574)2.05720290
64Asymmetry of the thorax (HP:0001555)2.04375557
65Abnormality of the fingertips (HP:0001211)2.03769360
66Progressive inability to walk (HP:0002505)2.02875430
67Abnormality of the aortic arch (HP:0012303)2.01884103
68Abnormality of the parietal bone (HP:0002696)2.01643371
69Thickened helices (HP:0000391)2.01560700
70Occipital encephalocele (HP:0002085)2.01504938
71Esotropia (HP:0000565)2.00749163
72Abnormality of the ischium (HP:0003174)1.99868562
73Fibular aplasia (HP:0002990)1.99670485
74Protruding tongue (HP:0010808)1.99454900
75Neurofibrillary tangles (HP:0002185)1.98925999
76Blue irides (HP:0000635)1.98774954
77Abnormality of the middle phalanges of the toes (HP:0010183)1.98299554
78Abnormality of salivation (HP:0100755)1.98000486
79Esophageal atresia (HP:0002032)1.97998472
80Preaxial foot polydactyly (HP:0001841)1.97099614
81Bladder diverticulum (HP:0000015)1.95549073
82Deformed tarsal bones (HP:0008119)1.94789899
83Impaired social interactions (HP:0000735)1.94071285
84Abnormal social behavior (HP:0012433)1.94071285
85Embryonal neoplasm (HP:0002898)1.93827560
86Abnormal respiratory motile cilium morphology (HP:0005938)1.92570810
87Abnormal respiratory epithelium morphology (HP:0012253)1.92570810
88Abnormality of dentin (HP:0010299)1.92385247
89Nasal polyposis (HP:0100582)1.92262689
90Gonadal dysgenesis (HP:0000133)1.92119714
91Protrusio acetabuli (HP:0003179)1.91368395
92Epileptiform EEG discharges (HP:0011182)1.90832880
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90381796
94Mixed hearing impairment (HP:0000410)1.89740652
95Anxiety (HP:0000739)1.89653930
96Hepatoblastoma (HP:0002884)1.87282176
97EEG with generalized epileptiform discharges (HP:0011198)1.87142833
98Rib fusion (HP:0000902)1.86771537
99Bronchomalacia (HP:0002780)1.86044195
100Hyperthyroidism (HP:0000836)1.85645348
101Hypoplastic ischia (HP:0003175)1.85478211
102Polyphagia (HP:0002591)1.83755807
103Aplasia involving bones of the extremities (HP:0009825)1.83192170
104Aplasia involving bones of the upper limbs (HP:0009823)1.83192170
105Aplasia of the phalanges of the hand (HP:0009802)1.83192170
106Broad distal phalanx of finger (HP:0009836)1.81099158
107Impaired vibration sensation in the lower limbs (HP:0002166)1.80204365
108Supranuclear gaze palsy (HP:0000605)1.79849713
109Dynein arm defect of respiratory motile cilia (HP:0012255)1.79332216
110Absent/shortened dynein arms (HP:0200106)1.79332216
111Mutism (HP:0002300)1.79246064
112Vascular tortuosity (HP:0004948)1.77939904
113Optic nerve hypoplasia (HP:0000609)1.77538715
114Cutaneous finger syndactyly (HP:0010554)1.77172866
115Infantile muscular hypotonia (HP:0008947)1.76698110
116Arterial tortuosity (HP:0005116)1.76258678
117Abnormality of the labia minora (HP:0012880)1.75923848
118Hypsarrhythmia (HP:0002521)1.75855263
119Oligodactyly (hands) (HP:0001180)1.75753572
120Specific learning disability (HP:0001328)1.75327661
121Tented upper lip vermilion (HP:0010804)1.75298312
122Renal duplication (HP:0000075)1.74518450
123Agitation (HP:0000713)1.74415339
124Buphthalmos (HP:0000557)1.74383582
125True hermaphroditism (HP:0010459)1.73517890
126Humeroradial synostosis (HP:0003041)1.73306849
127Synostosis involving the elbow (HP:0003938)1.73306849
128Lissencephaly (HP:0001339)1.73149891
129Anophthalmia (HP:0000528)1.73056543
130Tracheomalacia (HP:0002779)1.72824328
131Oligodactyly (HP:0012165)1.72404273
132Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72154496
133Breast carcinoma (HP:0003002)1.72066455
134Abnormality of the calcaneus (HP:0008364)1.71334636
135Depression (HP:0000716)1.70462485
136Abnormal number of incisors (HP:0011064)1.70204051
137Morphological abnormality of the inner ear (HP:0011390)1.69832349
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.69579480
139Nephronophthisis (HP:0000090)1.69162309
140Autism (HP:0000717)1.68475607
141Action tremor (HP:0002345)1.68458580
142Sleep apnea (HP:0010535)1.67944474
143Absent septum pellucidum (HP:0001331)1.67891149
144Synostosis of carpal bones (HP:0005048)1.66635704
145Inability to walk (HP:0002540)1.66629458
146Abnormal eating behavior (HP:0100738)1.66029906
147Abnormality of the phalanges of the hallux (HP:0010057)1.65474457
148Gait imbalance (HP:0002141)1.65351936
149Obstructive sleep apnea (HP:0002870)1.64606077
150Renal hypoplasia (HP:0000089)1.63384811
151Pachygyria (HP:0001302)1.63336018
152Premature rupture of membranes (HP:0001788)1.62999672
153Intellectual disability, moderate (HP:0002342)1.62709313
154Abnormality of midbrain morphology (HP:0002418)1.61867686
155Molar tooth sign on MRI (HP:0002419)1.61867686
156Hypoventilation (HP:0002791)1.60629269
157Vitreoretinal degeneration (HP:0000655)1.59451618
158Overriding aorta (HP:0002623)1.59062558
159Aortic dissection (HP:0002647)1.58167229
160Abnormality of the incisor (HP:0000676)1.57451027
161Alacrima (HP:0000522)1.57265175
162Broad finger (HP:0001500)1.56257338
163Abnormality of the antihelix (HP:0009738)1.55166740
164Broad toe (HP:0001837)1.55164235
165Duplication of thumb phalanx (HP:0009942)1.54719110
166Neoplasm of the heart (HP:0100544)1.54369668
167Arnold-Chiari malformation (HP:0002308)1.54142728
168Deviation of the hallux (HP:0010051)1.52862230
169Down-sloping shoulders (HP:0200021)1.52011456
170Broad thumb (HP:0011304)1.51952066
171Hypoplastic left heart (HP:0004383)1.51033015
172Gastrointestinal atresia (HP:0002589)1.50982127
173Supernumerary ribs (HP:0005815)1.50868609
174Sacral dimple (HP:0000960)1.50054113
175Abnormality of the phalanges of the 2nd finger (HP:0009541)1.49573441
176Soft skin (HP:0000977)1.49567590
177Torticollis (HP:0000473)1.48824466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.47794534
2CASK3.65614161
3MAP3K123.23742026
4NTRK33.15332149
5EPHA42.83319572
6PNCK2.52677018
7NTRK22.39406142
8TLK12.33850661
9TAOK22.32418299
10PRPF4B2.23333406
11MAP3K42.23276892
12MAP2K72.19785311
13DAPK22.15305244
14MAPK132.00669657
15MINK11.88864183
16SIK21.87338748
17EPHA31.83384241
18MAPK151.82432179
19TNIK1.82327355
20MAP3K91.73595343
21MKNK21.56376281
22EPHB21.55938393
23PAK61.50596088
24UHMK11.42751174
25RPS6KA21.42636558
26DDR21.41876941
27DAPK11.41265709
28PLK21.33069887
29KSR11.28166493
30PDGFRA1.26993616
31DAPK31.25329616
32STK111.23649506
33CSNK1G21.22730920
34MYLK1.20670723
35CDK51.19200371
36CAMK1G1.19057242
37DYRK21.18348088
38MAP2K41.15200114
39PHKG11.10485796
40PHKG21.10485796
41CSNK1G31.09466830
42PINK11.09352617
43LIMK11.08889177
44CCNB11.05038692
45NTRK11.04823565
46MAP3K101.03394499
47CSNK1A1L1.02910731
48CDK191.02339952
49PKN10.98170668
50MKNK10.96666084
51SGK20.95638346
52LATS20.94651011
53ICK0.94625596
54LATS10.94191403
55FGR0.94158368
56PRKCG0.92926455
57ROCK20.90586779
58DYRK1B0.88610353
59FES0.86687560
60DYRK30.86246243
61RIPK40.84024136
62DYRK1A0.83755430
63GRK50.82210435
64PRKCZ0.81535958
65ERBB30.81371333
66PAK30.80754374
67CAMK2A0.79337460
68ROCK10.78636082
69MUSK0.77976231
70FGFR20.76047841
71CSNK1G10.75070510
72CDK150.74724002
73CDK140.74597499
74TYRO30.74434750
75CDK180.74105191
76BCR0.72333424
77WEE10.71393194
78NME10.69858487
79PRKCH0.68596652
80CAMK2B0.66820754
81CDK11A0.65880536
82FGFR10.65851882
83ERBB20.65565342
84CLK10.65319832
85RPS6KC10.62830980
86RPS6KL10.62830980
87OXSR10.62292147
88CDK80.62189922
89WNK10.60551532
90PRKCE0.57298018
91STK38L0.56850679
92PTK2B0.55937219
93CAMK10.55444319
94MAP2K60.52073316
95STK390.51073839
96SGK30.50835776
97MARK20.49721155
98ILK0.48685687
99FYN0.48298097
100ADRBK10.48270407
101SIK10.47403521
102KSR20.47319584
103PAK20.46246676
104PRKD30.44783095
105CDC42BPA0.44599760
106PTK20.44494530
107BMPR20.42397270
108RIPK10.42283492
109NEK20.42021526
110RPS6KA60.41977546
111MAPK100.41485813
112MOS0.41014186
113SRPK10.40963888
114TRIB30.40870024
115CAMKK10.40775623
116CAMK40.40335831
117WNK30.40258957
118PRKG10.38837491
119HIPK20.38657017
120RET0.38351340
121PDGFRB0.38174146
122TGFBR10.37924917
123PRKD20.37459427
124GRK70.36386658
125MAP3K60.36155006
126SGK4940.35471534
127SGK2230.35471534
128PKN20.35367659
129WNK40.35302620
130CDK30.35207926
131SGK10.34743768
132CSNK1E0.34121767
133MTOR0.32541802

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.72302966
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80516853
3GABAergic synapse_Homo sapiens_hsa047272.76862061
4Glutamatergic synapse_Homo sapiens_hsa047242.73975942
5Circadian entrainment_Homo sapiens_hsa047132.52561634
6Morphine addiction_Homo sapiens_hsa050322.46845061
7Long-term potentiation_Homo sapiens_hsa047202.16097818
8Synaptic vesicle cycle_Homo sapiens_hsa047212.16064557
9Axon guidance_Homo sapiens_hsa043602.13133470
10Serotonergic synapse_Homo sapiens_hsa047262.10243282
11Dopaminergic synapse_Homo sapiens_hsa047282.06189084
12Oxidative phosphorylation_Homo sapiens_hsa001901.91905776
13Long-term depression_Homo sapiens_hsa047301.91033980
14Cholinergic synapse_Homo sapiens_hsa047251.85975066
15Olfactory transduction_Homo sapiens_hsa047401.83900062
16Cardiac muscle contraction_Homo sapiens_hsa042601.79449690
17Taste transduction_Homo sapiens_hsa047421.77826644
18Amphetamine addiction_Homo sapiens_hsa050311.77435400
19Alzheimers disease_Homo sapiens_hsa050101.73815075
20Parkinsons disease_Homo sapiens_hsa050121.64317488
21Salivary secretion_Homo sapiens_hsa049701.62378383
22Renin secretion_Homo sapiens_hsa049241.58662795
23Melanogenesis_Homo sapiens_hsa049161.52551624
24Hedgehog signaling pathway_Homo sapiens_hsa043401.50611002
25Cocaine addiction_Homo sapiens_hsa050301.50471994
26Gastric acid secretion_Homo sapiens_hsa049711.48865175
27Oxytocin signaling pathway_Homo sapiens_hsa049211.46866219
28Gap junction_Homo sapiens_hsa045401.46481449
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46132530
30Basal cell carcinoma_Homo sapiens_hsa052171.40631986
31Insulin secretion_Homo sapiens_hsa049111.38660566
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38647784
33Ether lipid metabolism_Homo sapiens_hsa005651.34090840
34GnRH signaling pathway_Homo sapiens_hsa049121.32024261
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28414519
36Huntingtons disease_Homo sapiens_hsa050161.27629894
37Calcium signaling pathway_Homo sapiens_hsa040201.26326616
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25915122
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24027082
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20425903
41ECM-receptor interaction_Homo sapiens_hsa045121.19850884
42Wnt signaling pathway_Homo sapiens_hsa043101.18493312
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14275217
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13511885
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12219775
46ErbB signaling pathway_Homo sapiens_hsa040121.06772011
47Estrogen signaling pathway_Homo sapiens_hsa049151.06309124
48Collecting duct acid secretion_Homo sapiens_hsa049661.06307961
49TGF-beta signaling pathway_Homo sapiens_hsa043501.05293706
50Phototransduction_Homo sapiens_hsa047441.05266528
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04950092
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02883780
53Glioma_Homo sapiens_hsa052141.00708118
54cAMP signaling pathway_Homo sapiens_hsa040240.92098770
55Renal cell carcinoma_Homo sapiens_hsa052110.90998557
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90811336
57Protein digestion and absorption_Homo sapiens_hsa049740.90338764
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89717071
59Notch signaling pathway_Homo sapiens_hsa043300.89316449
60Dorso-ventral axis formation_Homo sapiens_hsa043200.88940130
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87937847
62Alcoholism_Homo sapiens_hsa050340.79319521
63Dilated cardiomyopathy_Homo sapiens_hsa054140.78495916
64Ras signaling pathway_Homo sapiens_hsa040140.77997050
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77549378
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73264070
67Hippo signaling pathway_Homo sapiens_hsa043900.73112073
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73093993
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72390505
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72237863
71Choline metabolism in cancer_Homo sapiens_hsa052310.71248347
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.70645915
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70538137
74MicroRNAs in cancer_Homo sapiens_hsa052060.69846150
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.69435713
76Ribosome_Homo sapiens_hsa030100.67556518
77Bile secretion_Homo sapiens_hsa049760.67456777
78MAPK signaling pathway_Homo sapiens_hsa040100.66988365
79Focal adhesion_Homo sapiens_hsa045100.66120184
80Adherens junction_Homo sapiens_hsa045200.64610244
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62023568
82Rap1 signaling pathway_Homo sapiens_hsa040150.60222790
83Steroid biosynthesis_Homo sapiens_hsa001000.58964081
84Vibrio cholerae infection_Homo sapiens_hsa051100.57658061
85Proteoglycans in cancer_Homo sapiens_hsa052050.57639775
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57224588
87Oocyte meiosis_Homo sapiens_hsa041140.55572711
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.54616600
89Type II diabetes mellitus_Homo sapiens_hsa049300.53876625
90Tight junction_Homo sapiens_hsa045300.52814787
91Endometrial cancer_Homo sapiens_hsa052130.51655143
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51445227
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50665737
94Colorectal cancer_Homo sapiens_hsa052100.49463404
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47408308
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47011750
97AMPK signaling pathway_Homo sapiens_hsa041520.46762405
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45893210
99African trypanosomiasis_Homo sapiens_hsa051430.45277089
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45151793
101Ovarian steroidogenesis_Homo sapiens_hsa049130.43458420
102Melanoma_Homo sapiens_hsa052180.42459367
103Pathways in cancer_Homo sapiens_hsa052000.42040067
104VEGF signaling pathway_Homo sapiens_hsa043700.40599006
105Pancreatic secretion_Homo sapiens_hsa049720.40509792
106Prion diseases_Homo sapiens_hsa050200.40341745
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.38676250
108Prostate cancer_Homo sapiens_hsa052150.38599665
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38403190
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38358203
111Thyroid hormone synthesis_Homo sapiens_hsa049180.37824960
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37145330
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34025350
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.31413276
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31105080
116FoxO signaling pathway_Homo sapiens_hsa040680.30449145
117Circadian rhythm_Homo sapiens_hsa047100.29954358
118Butanoate metabolism_Homo sapiens_hsa006500.29860929
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27677477

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