NR2F2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerulus development (GO:0032835)6.79761501
2metanephric mesenchyme development (GO:0072075)6.66645582
3kidney mesenchyme development (GO:0072074)6.60171886
4mesenchymal cell differentiation involved in kidney development (GO:0072161)6.59073684
5mesenchymal cell differentiation involved in renal system development (GO:2001012)6.59073684
6cell differentiation involved in metanephros development (GO:0072202)5.94374947
7diaphragm development (GO:0060539)5.59278757
8skeletal muscle organ development (GO:0060538)5.08608169
9mesonephros development (GO:0001823)5.05365969
10mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.02993829
11gonadal mesoderm development (GO:0007506)4.99778008
12cell differentiation involved in kidney development (GO:0061005)4.92183013
13proximal/distal pattern formation (GO:0009954)4.53657949
14mesenchymal to epithelial transition (GO:0060231)4.37770323
15metanephros development (GO:0001656)4.32390767
16planar cell polarity pathway involved in neural tube closure (GO:0090179)4.31872599
17chondrocyte proliferation (GO:0035988)4.27972195
18lung vasculature development (GO:0060426)4.24497200
19positive regulation of male gonad development (GO:2000020)4.19627959
20respiratory tube development (GO:0030323)4.15365709
21embryonic skeletal joint morphogenesis (GO:0060272)4.13803995
22nephron epithelium morphogenesis (GO:0072088)4.09704811
23nephron tubule morphogenesis (GO:0072078)4.09704811
24cell proliferation involved in metanephros development (GO:0072203)4.05925449
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.96317629
26cell proliferation involved in kidney development (GO:0072111)3.91501286
27peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.90231899
28mesenchymal cell differentiation (GO:0048762)3.84818537
29regulation of male gonad development (GO:2000018)3.84233267
30pattern specification involved in kidney development (GO:0061004)3.78367086
31midgut development (GO:0007494)3.76750987
32metanephric epithelium development (GO:0072207)3.75419615
33neural crest cell development (GO:0014032)3.72615027
34negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.63872551
35outer ear morphogenesis (GO:0042473)3.62647652
36negative regulation of catenin import into nucleus (GO:0035414)3.60488275
37renal tubule morphogenesis (GO:0061333)3.54881175
38branching involved in ureteric bud morphogenesis (GO:0001658)3.53923739
39limb bud formation (GO:0060174)3.48937738
40regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.48571436
41positive regulation of mesonephros development (GO:0061213)3.47570684
42epithelial cell differentiation involved in kidney development (GO:0035850)3.45170000
43ureteric bud development (GO:0001657)3.45039089
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.45005041
45mesonephric tubule development (GO:0072164)3.41040540
46mesenchymal cell development (GO:0014031)3.40298032
47generation of neurons (GO:0048699)3.40149842
48mesenchyme morphogenesis (GO:0072132)3.39562882
49regulation of mesonephros development (GO:0061217)3.38613067
50lateral sprouting from an epithelium (GO:0060601)3.37516193
51mesonephric epithelium development (GO:0072163)3.35691942
52regulation of glomerulus development (GO:0090192)3.34386008
53forelimb morphogenesis (GO:0035136)3.34037281
54positive regulation of metanephros development (GO:0072216)3.33832880
55glomerular basement membrane development (GO:0032836)3.32676579
56regulation of non-canonical Wnt signaling pathway (GO:2000050)3.32199396
57regulation of mesenchymal cell apoptotic process (GO:2001053)3.30444170
58collagen fibril organization (GO:0030199)3.28951302
59non-canonical Wnt signaling pathway (GO:0035567)3.28106967
60regulation of establishment of planar polarity (GO:0090175)3.27139736
61mesenchymal cell proliferation (GO:0010463)3.27111592
62regulation of organ formation (GO:0003156)3.22887490
63cranial nerve morphogenesis (GO:0021602)3.21576650
64embryonic forelimb morphogenesis (GO:0035115)3.19833547
65kidney morphogenesis (GO:0060993)3.18922592
66organ induction (GO:0001759)3.15429462
67adrenal gland development (GO:0030325)3.12548119
68muscle cell fate commitment (GO:0042693)3.11418701
69establishment of planar polarity (GO:0001736)3.10303634
70establishment of tissue polarity (GO:0007164)3.10303634
71negative regulation of metanephros development (GO:0072217)3.06063521
72metanephric nephron tubule development (GO:0072234)3.05619847
73metanephric tubule development (GO:0072170)3.05619847
74basement membrane organization (GO:0071711)3.05100293
75embryonic digestive tract morphogenesis (GO:0048557)3.03640687
76regulation of metanephros development (GO:0072215)3.03465055
77pyrimidine nucleobase catabolic process (GO:0006208)3.03249359
78regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.02848204
79negative regulation of embryonic development (GO:0045992)3.00664950
80mesenchymal-epithelial cell signaling (GO:0060638)2.97871105
81embryonic digit morphogenesis (GO:0042733)2.96932297
82bone trabecula formation (GO:0060346)2.96741042
83regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.96640272
84negative regulation of chondrocyte differentiation (GO:0032331)2.96012301
85regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.95141959
86negative regulation of stem cell proliferation (GO:2000647)2.94296452
87notochord development (GO:0030903)2.93583289
88positive regulation of gastrulation (GO:2000543)2.93487241
89urogenital system development (GO:0001655)2.91918768
90cell migration involved in heart development (GO:0060973)2.91064839
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.88420573
92mesenchyme development (GO:0060485)2.86072834
93embryonic digestive tract development (GO:0048566)2.85604638
94kidney epithelium development (GO:0072073)2.84663761
95stem cell development (GO:0048864)2.84379928
96axon extension (GO:0048675)2.84237945
97head development (GO:0060322)2.84016134
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.83738918
99branching involved in salivary gland morphogenesis (GO:0060445)2.83405319
100lens fiber cell development (GO:0070307)2.83045797
101cranial nerve structural organization (GO:0021604)2.82774746
102regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.82652438
103regulation of axon extension involved in axon guidance (GO:0048841)2.82564257
104convergent extension (GO:0060026)2.82558717
105negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.81696316
106paraxial mesoderm development (GO:0048339)2.81586862
107dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.81502098
108positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.80667295
109positive regulation of cartilage development (GO:0061036)2.80348682
110middle ear morphogenesis (GO:0042474)2.79564241
111regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.79509901
112cochlea morphogenesis (GO:0090103)2.79417003
113smooth muscle tissue development (GO:0048745)2.79334279
114uterus development (GO:0060065)2.77243555
115camera-type eye morphogenesis (GO:0048593)2.77025405
116regulation of axon guidance (GO:1902667)2.77021129
117lymphangiogenesis (GO:0001946)2.75468432
118regulation of kidney development (GO:0090183)2.74710894
119neuron projection extension involved in neuron projection guidance (GO:1902284)2.71997842
120axon extension involved in axon guidance (GO:0048846)2.71997842
121negative regulation of axon guidance (GO:1902668)2.71920554
122cell-cell signaling involved in cell fate commitment (GO:0045168)2.70520262
123developmental induction (GO:0031128)2.69361336
124metanephric nephron epithelium development (GO:0072243)2.69241744
125G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.69202757
126regulation of heart morphogenesis (GO:2000826)2.69196265
127negative regulation of glycogen metabolic process (GO:0070874)2.69180656
128vascular endothelial growth factor signaling pathway (GO:0038084)2.68019728
129endocardial cushion morphogenesis (GO:0003203)2.67905040
130nephron tubule development (GO:0072080)2.67517287
131positive regulation of kidney development (GO:0090184)2.67391701
132positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.63788758
133artery development (GO:0060840)2.63582382
134nephron tubule formation (GO:0072079)2.63078558
135aorta morphogenesis (GO:0035909)2.59236041
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.58828831
137regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57229702
138embryonic foregut morphogenesis (GO:0048617)2.54657437
139positive regulation of odontogenesis (GO:0042482)2.53813927
140viral transcription (GO:0019083)2.53284880
141hippo signaling (GO:0035329)2.52937429
142embryonic skeletal system morphogenesis (GO:0048704)2.51320087
143muscle cell migration (GO:0014812)2.50276321
144positive regulation of embryonic development (GO:0040019)2.49662349
145negative regulation of kidney development (GO:0090185)2.49459007
146atrioventricular valve morphogenesis (GO:0003181)2.49381493
147eye morphogenesis (GO:0048592)2.47676466
148embryonic camera-type eye morphogenesis (GO:0048596)2.47609792
149renal filtration (GO:0097205)2.46444395
150negative regulation of cartilage development (GO:0061037)2.45439719
151protein heterotrimerization (GO:0070208)2.43968492
152outflow tract septum morphogenesis (GO:0003148)2.43885860
153regulation of transforming growth factor beta2 production (GO:0032909)2.42092697
154embryonic cranial skeleton morphogenesis (GO:0048701)2.41835929
155regulation of chondrocyte differentiation (GO:0032330)2.39478565
156glomerular filtration (GO:0003094)2.38951509
157cardiac septum morphogenesis (GO:0060411)2.37564063
158neuron projection extension (GO:1990138)2.37257655
159translational termination (GO:0006415)2.36637524
160regulation of cardioblast differentiation (GO:0051890)2.36481598
161myoblast fusion (GO:0007520)2.35772806
162prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.34861302
163endothelial cell chemotaxis (GO:0035767)2.34692245
164regulation of catenin import into nucleus (GO:0035412)2.34072006
165positive regulation of chondrocyte differentiation (GO:0032332)2.33141513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.95691900
2EZH2_22144423_ChIP-Seq_EOC_Human3.91739447
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.75110267
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.41815822
5* EED_16625203_ChIP-ChIP_MESCs_Mouse3.26764605
6GBX2_23144817_ChIP-Seq_PC3_Human2.96553723
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82994453
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.82719424
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.80051085
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.77888444
11* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77515422
12* CBX2_27304074_Chip-Seq_ESCs_Mouse2.75764745
13* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.72033847
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68534723
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68534723
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60326517
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52535959
18* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48444065
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45604876
20* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.45553825
21* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.40464835
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38120230
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15922024
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.13401464
25* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.01570715
26ESR2_21235772_ChIP-Seq_MCF-7_Human2.00234729
27* RNF2_27304074_Chip-Seq_ESCs_Mouse2.00048640
28* RNF2_27304074_Chip-Seq_NSC_Mouse1.94572258
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.90922344
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90453924
31TAF15_26573619_Chip-Seq_HEK293_Human1.87096043
32* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85014759
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.84357748
34VDR_22108803_ChIP-Seq_LS180_Human1.82837019
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81067410
36* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80161760
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79841487
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75512675
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72461001
40* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71245723
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68807880
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68780807
43AR_21572438_ChIP-Seq_LNCaP_Human1.68775503
44* P300_19829295_ChIP-Seq_ESCs_Human1.67477132
45* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66094149
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.65982265
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65149011
48* TP53_20018659_ChIP-ChIP_R1E_Mouse1.63023023
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.59977636
50* FUS_26573619_Chip-Seq_HEK293_Human1.59974563
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58587888
52* RING1B_27294783_Chip-Seq_NPCs_Mouse1.57481588
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51422068
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.50130697
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49029146
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.47979219
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47388777
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46756900
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46635492
60* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45110038
61* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44121062
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40833277
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40322514
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39840700
65EWS_26573619_Chip-Seq_HEK293_Human1.39455395
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38857102
67SMAD4_21799915_ChIP-Seq_A2780_Human1.38774738
68* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37891377
69* RING1B_27294783_Chip-Seq_ESCs_Mouse1.35936019
70TP53_18474530_ChIP-ChIP_U2OS_Human1.35084086
71* ISL1_27105846_Chip-Seq_CPCs_Mouse1.34996707
72* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33843978
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.33235515
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32785949
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32785949
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32785949
77* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31838256
78KDM2B_26808549_Chip-Seq_K562_Human1.30744919
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.30572282
80* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30061377
81* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28390533
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26635446
83* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25768957
84ZNF263_19887448_ChIP-Seq_K562_Human1.25545691
85IGF1R_20145208_ChIP-Seq_DFB_Human1.24046039
86* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23932488
87* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23282944
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22410487
89* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21876171
90NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21210865
91* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20786678
92* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20340103
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.20096951
94* CDX2_20551321_ChIP-Seq_CACO-2_Human1.18871277
95* RACK7_27058665_Chip-Seq_MCF-7_Human1.15785963
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15686125
97* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15378485
98* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14083034
99* ARNT_22903824_ChIP-Seq_MCF-7_Human1.13830351
100ZNF274_21170338_ChIP-Seq_K562_Hela1.10964177
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07750515
102* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06871997
103TP53_22127205_ChIP-Seq_IMR90_Human1.05938803
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.05664334
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05599150
106BCAT_22108803_ChIP-Seq_LS180_Human1.04422903
107ELK3_25401928_ChIP-Seq_HUVEC_Human1.03176890
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02238253
109* AHR_22903824_ChIP-Seq_MCF-7_Human1.02087969
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.01024488
111* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00390250
112* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98441385
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98283090
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98129662
115SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97919371
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97527127
117* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97113692
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96915104
119* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96496712
120CJUN_26792858_Chip-Seq_BT549_Human0.96334284
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95823957
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95785077
123RUNX2_22187159_ChIP-Seq_PCA_Human0.95692572
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95633737
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95301535
126ER_23166858_ChIP-Seq_MCF-7_Human0.94613151
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94253498
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94253498
129AR_25329375_ChIP-Seq_VCAP_Human0.93923104
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93894818
131* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93466935
132JUN_21703547_ChIP-Seq_K562_Human0.93284032
133SA1_22415368_ChIP-Seq_MEFs_Mouse0.93078298
134* UBF1/2_26484160_Chip-Seq_HMECs_Human0.92035447
135* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91572756
136* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91572756
137* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90918300
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89728630
139* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.88759814
140FOXM1_23109430_ChIP-Seq_U2OS_Human0.88127232
141* CLOCK_20551151_ChIP-Seq_293T_Human0.88026599
142* AR_19668381_ChIP-Seq_PC3_Human0.88012684
143KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87629387
144TP53_23651856_ChIP-Seq_MEFs_Mouse0.87225264
145* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87057266
146P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86790183
147CTCF_27219007_Chip-Seq_Bcells_Human0.86618545
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86380755
149* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85191506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.79134460
2MP0005503_abnormal_tendon_morphology3.61309354
3MP0003942_abnormal_urinary_system3.36921620
4MP0003385_abnormal_body_wall3.12334712
5MP0000534_abnormal_ureter_morphology2.95933581
6MP0008438_abnormal_cutaneous_collagen2.95558578
7MP0003705_abnormal_hypodermis_morpholog2.79721332
8MP0002249_abnormal_larynx_morphology2.77982441
9MP0003123_paternal_imprinting2.49577980
10MP0009250_abnormal_appendicular_skeleto2.49442580
11MP0000537_abnormal_urethra_morphology2.38293678
12MP0009053_abnormal_anal_canal2.37046007
13MP0002282_abnormal_trachea_morphology2.27365610
14MP0004272_abnormal_basement_membrane2.26449703
15MP0003121_genomic_imprinting2.25601247
16MP0003115_abnormal_respiratory_system2.23524968
17MP0010030_abnormal_orbit_morphology2.14459052
18MP0000049_abnormal_middle_ear2.11747233
19MP0002938_white_spotting2.10482701
20MP0003283_abnormal_digestive_organ2.10329704
21MP0005257_abnormal_intraocular_pressure2.04925932
22MP0009379_abnormal_foot_pigmentation1.99840934
23MP0005275_abnormal_skin_tensile1.98566291
24MP0001346_abnormal_lacrimal_gland1.97321000
25MP0003941_abnormal_skin_development1.80283242
26MP0000566_synostosis1.80171918
27MP0009780_abnormal_chondrocyte_physiolo1.78935259
28MP0003315_abnormal_perineum_morphology1.73446611
29MP0003938_abnormal_ear_development1.71269495
30MP0005248_abnormal_Harderian_gland1.69993923
31MP0005367_renal/urinary_system_phenotyp1.68563204
32MP0000516_abnormal_urinary_system1.68563204
33MP0010368_abnormal_lymphatic_system1.66275563
34MP0005623_abnormal_meninges_morphology1.65886780
35MP0002102_abnormal_ear_morphology1.60713236
36MP0003755_abnormal_palate_morphology1.59289474
37MP0001299_abnormal_eye_distance/1.56715273
38MP0000778_abnormal_nervous_system1.55896170
39MP0000733_abnormal_muscle_development1.54532480
40* MP0001879_abnormal_lymphatic_vessel1.53411681
41MP0009384_cardiac_valve_regurgitation1.50334613
42MP0001177_atelectasis1.47612873
43MP0002932_abnormal_joint_morphology1.47006208
44MP0001188_hyperpigmentation1.46729824
45MP0002108_abnormal_muscle_morphology1.46187839
46MP0003787_abnormal_imprinting1.45982101
47MP0000678_abnormal_parathyroid_gland1.43062786
48MP0000462_abnormal_digestive_system1.42661018
49MP0003937_abnormal_limbs/digits/tail_de1.42111475
50MP0004133_heterotaxia1.38467245
51MP0009697_abnormal_copulation1.38123661
52MP0005409_darkened_coat_color1.35950050
53MP0005508_abnormal_skeleton_morphology1.26890497
54MP0001958_emphysema1.26093016
55MP0003195_calcinosis1.21916617
56MP0002233_abnormal_nose_morphology1.19839363
57MP0006276_abnormal_autonomic_nervous1.19741925
58MP0001270_distended_abdomen1.19306397
59MP0003566_abnormal_cell_adhesion1.17081674
60MP0002116_abnormal_craniofacial_bone1.16071281
61MP0000767_abnormal_smooth_muscle1.15530629
62MP0003935_abnormal_craniofacial_develop1.11912269
63MP0002896_abnormal_bone_mineralization1.10593808
64MP0003119_abnormal_digestive_system1.10533192
65MP0005187_abnormal_penis_morphology1.09948408
66MP0003091_abnormal_cell_migration1.07490269
67MP0002177_abnormal_outer_ear1.06615879
68MP0002109_abnormal_limb_morphology1.06180829
69MP0001286_abnormal_eye_development1.04137848
70MP0002092_abnormal_eye_morphology1.02804189
71MP0000762_abnormal_tongue_morphology1.02759148
72MP0002184_abnormal_innervation1.01759647
73MP0005076_abnormal_cell_differentiation0.97407228
74MP0000163_abnormal_cartilage_morphology0.97349305
75MP0008789_abnormal_olfactory_epithelium0.95033728
76MP0002160_abnormal_reproductive_system0.94957149
77MP0002127_abnormal_cardiovascular_syste0.94803500
78MP0002114_abnormal_axial_skeleton0.94500869
79MP0005595_abnormal_vascular_smooth0.93482715
80MP0000639_abnormal_adrenal_gland0.92954124
81MP0003279_aneurysm0.92684781
82MP0000428_abnormal_craniofacial_morphol0.89984067
83MP0005084_abnormal_gallbladder_morpholo0.89763653
84MP0003880_abnormal_central_pattern0.88957127
85MP0000631_abnormal_neuroendocrine_gland0.86699354
86MP0002115_abnormal_skeleton_extremities0.86028317
87* MP0002085_abnormal_embryonic_tissue0.85835239
88MP0002697_abnormal_eye_size0.85436484
89MP0000003_abnormal_adipose_tissue0.85183975
90MP0002089_abnormal_postnatal_growth/wei0.84755054
91MP0003136_yellow_coat_color0.84703935
92MP0000538_abnormal_urinary_bladder0.83911921
93MP0005388_respiratory_system_phenotype0.83522062
94MP0002133_abnormal_respiratory_system0.83522062
95MP0000432_abnormal_head_morphology0.83252664
96MP0005360_urolithiasis0.82832679
97* MP0002081_perinatal_lethality0.82345921
98MP0002877_abnormal_melanocyte_morpholog0.81790624
99MP0002234_abnormal_pharynx_morphology0.81032688
100MP0000467_abnormal_esophagus_morphology0.80298354
101MP0006138_congestive_heart_failure0.80165790
102MP0002557_abnormal_social/conspecific_i0.79112162
103MP0000026_abnormal_inner_ear0.79002071
104MP0004134_abnormal_chest_morphology0.78795389
105MP0000613_abnormal_salivary_gland0.78273523
106MP0003861_abnormal_nervous_system0.77703694
107MP0002113_abnormal_skeleton_development0.76824703
108MP0003936_abnormal_reproductive_system0.76106697
109MP0002111_abnormal_tail_morphology0.74632754
110MP0005197_abnormal_uvea_morphology0.73302492
111MP0001293_anophthalmia0.72479209
112MP0002295_abnormal_pulmonary_circulatio0.72171781
113MP0002009_preneoplasia0.71950561
114MP0003950_abnormal_plasma_membrane0.71086080
115MP0002084_abnormal_developmental_patter0.70699349
116MP0005389_reproductive_system_phenotype0.70263906
117MP0005171_absent_coat_pigmentation0.69399494
118* MP0002925_abnormal_cardiovascular_devel0.68489746
119MP0000955_abnormal_spinal_cord0.68223105
120MP0004883_abnormal_blood_vessel0.67738741
121MP0001175_abnormal_lung_morphology0.67397750
122MP0001340_abnormal_eyelid_morphology0.66861470
123MP0002751_abnormal_autonomic_nervous0.66590497
124MP0000013_abnormal_adipose_tissue0.65879352
125MP0001919_abnormal_reproductive_system0.64548010
126MP0003567_abnormal_fetal_cardiomyocyte0.64487390
127MP0003252_abnormal_bile_duct0.62186886
128MP0000751_myopathy0.61824375
129MP0004858_abnormal_nervous_system0.61525324
130MP0004019_abnormal_vitamin_homeostasis0.60536090
131MP0003878_abnormal_ear_physiology0.60340569
132MP0005377_hearing/vestibular/ear_phenot0.60340569

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.87409774
2Premature rupture of membranes (HP:0001788)4.78879072
3Diastasis recti (HP:0001540)3.64244204
4Embryonal renal neoplasm (HP:0011794)3.56827226
5Nephroblastoma (Wilms tumor) (HP:0002667)3.34037583
6Enlarged kidneys (HP:0000105)3.33231968
7Abnormality of incisor morphology (HP:0011063)3.20060229
8True hermaphroditism (HP:0010459)3.10668859
9Renal duplication (HP:0000075)2.99846759
10Morphological abnormality of the middle ear (HP:0008609)2.96475763
11Shawl scrotum (HP:0000049)2.95800676
12Abnormality of the nasolacrimal system (HP:0000614)2.93317071
13Abnormality of the lacrimal duct (HP:0011481)2.88650714
14Midline defect of the nose (HP:0004122)2.83501430
15Renal dysplasia (HP:0000110)2.81064996
16Bladder diverticulum (HP:0000015)2.78289684
17Coronal craniosynostosis (HP:0004440)2.70152882
18Asymmetry of the thorax (HP:0001555)2.62565373
19Nasolacrimal duct obstruction (HP:0000579)2.60500679
20Broad toe (HP:0001837)2.59590777
21* Hypoplastic left heart (HP:0004383)2.59302341
22Abnormality of the aortic arch (HP:0012303)2.57734081
23Overgrowth (HP:0001548)2.57115449
24Mitral valve prolapse (HP:0001634)2.55640086
25Potter facies (HP:0002009)2.50126406
26Facial shape deformation (HP:0011334)2.50126406
27Ulnar bowing (HP:0003031)2.49694998
28Cervical subluxation (HP:0003308)2.49404217
29Short 4th metacarpal (HP:0010044)2.47962052
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47962052
31Fragile skin (HP:0001030)2.45688898
32Spinal rigidity (HP:0003306)2.44154567
33Chorioretinal atrophy (HP:0000533)2.40178536
34Fibular hypoplasia (HP:0003038)2.38718713
35Germ cell neoplasia (HP:0100728)2.37396207
36Ankle contracture (HP:0006466)2.37324449
37Wide anterior fontanel (HP:0000260)2.36746841
38Abnormality of the pulmonary veins (HP:0011718)2.36131718
39Calcaneovalgus deformity (HP:0001848)2.33168759
40Periauricular skin pits (HP:0100277)2.32724818
41Preauricular pit (HP:0004467)2.32724818
42Atrophic scars (HP:0001075)2.32404919
43Abnormality of the nasal septum (HP:0000419)2.31676846
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.30895422
45Hypophosphatemic rickets (HP:0004912)2.30451081
46Neonatal short-limb short stature (HP:0008921)2.30394775
47Abnormality of the phalanges of the hallux (HP:0010057)2.30337752
48Genu recurvatum (HP:0002816)2.29347147
49Spinal cord lesions (HP:0100561)2.27895012
50Syringomyelia (HP:0003396)2.27895012
51Partial duplication of thumb phalanx (HP:0009944)2.25669584
52Myelomeningocele (HP:0002475)2.23866049
53Follicular hyperkeratosis (HP:0007502)2.23290863
54Recurrent corneal erosions (HP:0000495)2.20409491
55Short nail (HP:0001799)2.18054619
56Abnormality of dentin (HP:0010299)2.17765507
57Deformed tarsal bones (HP:0008119)2.16192316
58Renal hypoplasia (HP:0000089)2.14410298
59Anomalous pulmonary venous return (HP:0010772)2.13265589
60Abnormality of the incisor (HP:0000676)2.12354395
61Hypoplastic ischia (HP:0003175)2.12264607
62Embryonal neoplasm (HP:0002898)2.10892216
63Mesangial abnormality (HP:0001966)2.09803856
64Cutaneous finger syndactyly (HP:0010554)2.08951288
65Bicornuate uterus (HP:0000813)2.07778970
66Adrenal hypoplasia (HP:0000835)2.07717557
67Lymphangioma (HP:0100764)2.06500716
68Bronchomalacia (HP:0002780)2.05872415
69Bifid tongue (HP:0010297)2.05068371
70Abnormality of the calcaneus (HP:0008364)2.04441351
71Omphalocele (HP:0001539)2.04238473
72Abnormal pancreas size (HP:0012094)2.04216885
73Absent eyebrow (HP:0002223)2.02449879
74Absent eyelashes (HP:0000561)2.02415491
75Neoplasm of the liver (HP:0002896)2.00307333
76Abnormal lung lobation (HP:0002101)1.98585899
77Hyperextensible skin (HP:0000974)1.97591495
78Broad metatarsal (HP:0001783)1.97486676
79Blue sclerae (HP:0000592)1.96883265
80Abnormal ventriculo-arterial connection (HP:0011563)1.96288815
81Transposition of the great arteries (HP:0001669)1.96288815
82Abnormal connection of the cardiac segments (HP:0011545)1.96288815
83Hyperventilation (HP:0002883)1.96198630
84* Hypoplastic heart (HP:0001961)1.95997095
85Preaxial foot polydactyly (HP:0001841)1.95906783
86Occipital encephalocele (HP:0002085)1.95906147
87Protrusio acetabuli (HP:0003179)1.95021516
88Abnormality of the ischium (HP:0003174)1.94583384
89Soft skin (HP:0000977)1.93975475
90High anterior hairline (HP:0009890)1.93821077
91Abnormality of the 4th metacarpal (HP:0010012)1.92107835
92Joint laxity (HP:0001388)1.91927222
93Exotropia (HP:0000577)1.91777528
94Flared iliac wings (HP:0002869)1.91152950
95Mesomelia (HP:0003027)1.90339089
96Vascular tortuosity (HP:0004948)1.89581348
97Type 1 muscle fiber predominance (HP:0003803)1.88670204
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88000786
99Wormian bones (HP:0002645)1.87812054
100Absent hair (HP:0002298)1.87287363
101Buphthalmos (HP:0000557)1.87228867
102Genital tract atresia (HP:0001827)1.84527154
103Anophthalmia (HP:0000528)1.83952978
104Bowing of the arm (HP:0006488)1.83226196
105Bowed forearm bones (HP:0003956)1.83226196
106Pulmonary artery stenosis (HP:0004415)1.82829473
107Ectopia lentis (HP:0001083)1.82769209
108Cutaneous syndactyly (HP:0012725)1.82731584
109Bell-shaped thorax (HP:0001591)1.82590326
110Vaginal atresia (HP:0000148)1.82585464
111Abnormality of the axillary hair (HP:0100134)1.82515928
112Abnormality of secondary sexual hair (HP:0009888)1.82515928
113Abnormal ciliary motility (HP:0012262)1.81829810
114Vertebral arch anomaly (HP:0008438)1.80920949
115Abnormality of the parietal bone (HP:0002696)1.80720212
116Deviation of the hallux (HP:0010051)1.80399361
117Congenital glaucoma (HP:0001087)1.78719732
118Camptodactyly of toe (HP:0001836)1.78609578
119Stage 5 chronic kidney disease (HP:0003774)1.78480682
120Male pseudohermaphroditism (HP:0000037)1.77939887
121Mitral regurgitation (HP:0001653)1.77418124
122Aortic dissection (HP:0002647)1.75172031
123Short hallux (HP:0010109)1.74695143
124Broad face (HP:0000283)1.73996035
125Aplasia involving bones of the extremities (HP:0009825)1.73979341
126Aplasia involving bones of the upper limbs (HP:0009823)1.73979341
127Aplasia of the phalanges of the hand (HP:0009802)1.73979341
128Wrist flexion contracture (HP:0001239)1.73588801
129Aortic aneurysm (HP:0004942)1.73157181
130Abnormal hair whorl (HP:0010721)1.72346978
131Tracheomalacia (HP:0002779)1.72102464
132Pancreatic fibrosis (HP:0100732)1.72009173
133Disproportionate tall stature (HP:0001519)1.71840410
134Cerebral aneurysm (HP:0004944)1.71699140
135Shallow orbits (HP:0000586)1.70808611
136Hallux valgus (HP:0001822)1.70157070
137Hypoventilation (HP:0002791)1.70001685
138Infantile muscular hypotonia (HP:0008947)1.69618878
139Aortic regurgitation (HP:0001659)1.68965315
140Broad distal phalanx of finger (HP:0009836)1.68383605
141Abnormal number of incisors (HP:0011064)1.67845560
142Broad finger (HP:0001500)1.67828805
143Turricephaly (HP:0000262)1.67786080
144Down-sloping shoulders (HP:0200021)1.66480368
145Abnormality of the acetabulum (HP:0003170)1.66323652
146Arterial tortuosity (HP:0005116)1.66187432
147Obstructive sleep apnea (HP:0002870)1.65797139
148Hypoplasia of the iris (HP:0007676)1.64382449
149Aplasia/Hypoplasia of the fibula (HP:0006492)1.63950858
150Bowel diverticulosis (HP:0005222)1.63775119
151Partial duplication of the phalanx of hand (HP:0009999)1.62907273
152Spondylolisthesis (HP:0003302)1.61568963
153Broad hallux (HP:0010055)1.60385854
154Mildly elevated creatine phosphokinase (HP:0008180)1.60025028
155Sprengel anomaly (HP:0000912)1.58937430
156Long toe (HP:0010511)1.58721111
157Thin ribs (HP:0000883)1.57740936
158Broad long bones (HP:0005622)1.56815399
159Long eyelashes (HP:0000527)1.54514450
160Abnormality of the 2nd finger (HP:0004100)1.53132336
161Inguinal hernia (HP:0000023)1.52457978
162Aplasia/Hypoplasia of the clavicles (HP:0006710)1.52123752
163Osteoarthritis (HP:0002758)1.51574114
164Spinal cord compression (HP:0002176)1.50717216
165Limited hip movement (HP:0008800)1.50428641
166Hyperacusis (HP:0010780)1.49938001
167Arnold-Chiari malformation (HP:0002308)1.49328992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.80488446
2TRIB33.32729684
3AKT33.32237847
4MKNK22.94483154
5EPHB22.85379193
6SIK12.77227148
7ERBB32.71702662
8MAPK132.70338193
9MYLK2.64413263
10LATS12.63775026
11EPHA22.62572195
12NTRK12.61019629
13MKNK12.47505545
14ICK2.27124374
15MARK12.22469693
16LATS22.20301808
17MAPK152.10186591
18SGK22.01899383
19PNCK1.81433739
20WNK31.80713760
21MAP2K71.63736068
22NUAK11.55681589
23SGK4941.55597823
24SGK2231.55597823
25PLK21.52246723
26TTN1.52043950
27CDK81.49831368
28STK38L1.42874869
29WNK41.41614010
30PKN21.40326094
31FRK1.36895257
32FER1.35257559
33CDK121.34191494
34ERBB41.30868576
35BCR1.30148774
36MAP3K101.29863420
37PRPF4B1.28042563
38SGK31.27478132
39TGFBR11.27209019
40PDGFRA1.24512561
41TIE11.21376623
42MET1.20156635
43DMPK1.19277032
44RIPK11.17279328
45PKN11.17073157
46EPHA31.15580775
47MTOR1.15577025
48ZAK1.14430387
49CAMK1G1.13622439
50WNK11.12343248
51SRPK11.11923756
52EEF2K1.10560943
53PRKD31.08955839
54TAOK21.08621134
55CAMK41.08187797
56STK391.06834281
57NTRK31.02938420
58MAP3K41.02806539
59PLK31.02326994
60DYRK1A1.01823962
61YES11.01454232
62SIK21.01290748
63PIK3CA0.98239328
64PAK30.97041186
65PDGFRB0.95742277
66ILK0.94398425
67UHMK10.93259482
68PTK2B0.92584346
69EPHA40.91918841
70ROCK10.91118776
71TAF10.90610643
72SMG10.89028546
73NTRK20.88982917
74PRKCE0.88933071
75BMPR1B0.88046270
76ADRBK10.87764916
77STK380.87504816
78SIK30.87387499
79DYRK20.87084215
80NEK20.87083016
81VRK20.78172702
82TYRO30.77910889
83DDR20.74591365
84PAK20.73992115
85NEK60.73862779
86TNIK0.73838241
87MELK0.73118207
88RPS6KA20.69854458
89PRKCZ0.69435320
90MOS0.63843714
91OXSR10.63662761
92TNK20.63453950
93WEE10.63055818
94TGFBR20.63006833
95TESK10.62731023
96PRKCG0.62714010
97ERBB20.61730506
98ROCK20.60787607
99LRRK20.60667962
100KSR10.59828499
101GSK3A0.59761570
102MINK10.58248187
103NEK90.56119263
104TLK10.55041515
105CDK30.54206403
106FGFR20.53796860
107CDK70.53585284
108DYRK1B0.52108695
109CSNK1A1L0.51816410
110PAK40.51319465
111CAMK2A0.50210224
112MAPKAPK30.50052079
113RPS6KA60.49385174
114CDC42BPA0.49133034
115PHKG10.48193160
116PHKG20.48193160
117ABL20.47030668
118CAMK1D0.46996304
119MAP3K90.46933020
120CDK90.46194839
121VRK10.44869360
122EIF2AK20.44017847
123CAMK2B0.43741282
124MST1R0.43272654
125FGFR10.42517537
126RPS6KB20.42506764
127MAP2K10.41935201
128STK30.41459930
129MUSK0.41433668
130PRKD20.41190291
131PRKG10.40773799
132RET0.39972013
133LMTK20.39810844
134CHUK0.39592765
135MAP2K40.37685156
136TRPM70.37584857
137PTK60.37525844
138PTK20.37116198
139RPS6KC10.36829319
140RPS6KL10.36829319
141AKT20.36764601
142MAP3K60.36456102
143DYRK30.35406880
144CAMK2G0.35137803
145LIMK10.35119472
146MAPK90.35057601
147INSRR0.34088297
148PRKD10.33943423
149MARK20.33739305
150PRKACA0.33626062
151PASK0.33383633
152CDK11A0.33236860
153CDK150.31920549

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.98688135
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.05055040
3Butanoate metabolism_Homo sapiens_hsa006502.37882897
4Basal cell carcinoma_Homo sapiens_hsa052172.30053356
5Hedgehog signaling pathway_Homo sapiens_hsa043402.20721757
6Nicotine addiction_Homo sapiens_hsa050332.20057396
7Axon guidance_Homo sapiens_hsa043602.18557298
8TGF-beta signaling pathway_Homo sapiens_hsa043502.11187537
9Ribosome_Homo sapiens_hsa030102.04145367
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87734566
11Hippo signaling pathway_Homo sapiens_hsa043901.84148207
12Steroid hormone biosynthesis_Homo sapiens_hsa001401.83219188
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70884833
14Adherens junction_Homo sapiens_hsa045201.66059170
15Retinol metabolism_Homo sapiens_hsa008301.55255653
16GABAergic synapse_Homo sapiens_hsa047271.53548185
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51528526
18ECM-receptor interaction_Homo sapiens_hsa045121.50407731
19Melanogenesis_Homo sapiens_hsa049161.45438619
20Prostate cancer_Homo sapiens_hsa052151.41104904
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.35669244
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35312647
23Complement and coagulation cascades_Homo sapiens_hsa046101.31182065
24Wnt signaling pathway_Homo sapiens_hsa043101.29372974
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26711808
26Dilated cardiomyopathy_Homo sapiens_hsa054141.20546486
27Small cell lung cancer_Homo sapiens_hsa052221.19809765
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19235497
29Focal adhesion_Homo sapiens_hsa045101.18010843
30Melanoma_Homo sapiens_hsa052181.17995895
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16766032
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15183113
33Renal cell carcinoma_Homo sapiens_hsa052111.14424473
34Tryptophan metabolism_Homo sapiens_hsa003801.13740252
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12779165
36Fatty acid elongation_Homo sapiens_hsa000621.11695938
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10782018
38Ovarian steroidogenesis_Homo sapiens_hsa049131.09951494
39Bladder cancer_Homo sapiens_hsa052191.09116977
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08772787
41Chronic myeloid leukemia_Homo sapiens_hsa052201.08327487
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08262305
43Prion diseases_Homo sapiens_hsa050201.04709603
44Chemical carcinogenesis_Homo sapiens_hsa052041.04609630
45Taste transduction_Homo sapiens_hsa047421.04465555
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04464404
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04091469
48Gap junction_Homo sapiens_hsa045401.03718226
49Thyroid cancer_Homo sapiens_hsa052161.03579892
50beta-Alanine metabolism_Homo sapiens_hsa004101.03419996
51Endometrial cancer_Homo sapiens_hsa052131.03251068
52Amoebiasis_Homo sapiens_hsa051461.02047297
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.01805586
54Oxidative phosphorylation_Homo sapiens_hsa001900.98857155
55MicroRNAs in cancer_Homo sapiens_hsa052060.98658119
56ErbB signaling pathway_Homo sapiens_hsa040120.98177482
57Tight junction_Homo sapiens_hsa045300.98057591
58Protein digestion and absorption_Homo sapiens_hsa049740.96807856
59Propanoate metabolism_Homo sapiens_hsa006400.94575993
60Parkinsons disease_Homo sapiens_hsa050120.94083762
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93309428
62Estrogen signaling pathway_Homo sapiens_hsa049150.92832478
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92026904
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91988671
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91983891
66Lysine degradation_Homo sapiens_hsa003100.91660524
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91181541
68Cocaine addiction_Homo sapiens_hsa050300.90998966
69Serotonergic synapse_Homo sapiens_hsa047260.89988731
70Colorectal cancer_Homo sapiens_hsa052100.89913768
71AMPK signaling pathway_Homo sapiens_hsa041520.89873698
72Proteoglycans in cancer_Homo sapiens_hsa052050.89321540
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89161681
74Sulfur relay system_Homo sapiens_hsa041220.88991702
75Morphine addiction_Homo sapiens_hsa050320.86949747
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86121283
77Huntingtons disease_Homo sapiens_hsa050160.85437669
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85367926
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84385646
80Circadian entrainment_Homo sapiens_hsa047130.79881259
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78190045
82Starch and sucrose metabolism_Homo sapiens_hsa005000.76861065
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.75791662
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75751589
85Long-term depression_Homo sapiens_hsa047300.75443038
86Glutamatergic synapse_Homo sapiens_hsa047240.75216146
87Pathways in cancer_Homo sapiens_hsa052000.74980135
88Alzheimers disease_Homo sapiens_hsa050100.74818598
89Rap1 signaling pathway_Homo sapiens_hsa040150.74085867
90Cardiac muscle contraction_Homo sapiens_hsa042600.73265783
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72675316
92Cholinergic synapse_Homo sapiens_hsa047250.71258586
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.71153098
94Fatty acid degradation_Homo sapiens_hsa000710.69808433
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69259554
96Bile secretion_Homo sapiens_hsa049760.68950958
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68322329
98Renin secretion_Homo sapiens_hsa049240.68314012
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65734206
100Fatty acid metabolism_Homo sapiens_hsa012120.64742632
101Thyroid hormone synthesis_Homo sapiens_hsa049180.64505190
102Tyrosine metabolism_Homo sapiens_hsa003500.64375615
103PPAR signaling pathway_Homo sapiens_hsa033200.63506100
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62486385
105Amphetamine addiction_Homo sapiens_hsa050310.61915978
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61202547
107Vitamin digestion and absorption_Homo sapiens_hsa049770.60387131
108Arachidonic acid metabolism_Homo sapiens_hsa005900.60119174
109Peroxisome_Homo sapiens_hsa041460.58901489
110Choline metabolism in cancer_Homo sapiens_hsa052310.58849221
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.58296716
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56419647
113Dopaminergic synapse_Homo sapiens_hsa047280.54460509
114Insulin signaling pathway_Homo sapiens_hsa049100.54150612
115Pancreatic cancer_Homo sapiens_hsa052120.54097056
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.53914559
117Notch signaling pathway_Homo sapiens_hsa043300.52325072
118Glioma_Homo sapiens_hsa052140.51754096
119Gastric acid secretion_Homo sapiens_hsa049710.51594563
120Dorso-ventral axis formation_Homo sapiens_hsa043200.50849257
121MAPK signaling pathway_Homo sapiens_hsa040100.50772602
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50737358
123Vibrio cholerae infection_Homo sapiens_hsa051100.50175473
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48323756
125Phenylalanine metabolism_Homo sapiens_hsa003600.48252274
126Calcium signaling pathway_Homo sapiens_hsa040200.47881801
127GnRH signaling pathway_Homo sapiens_hsa049120.45708501
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45550941
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45278748
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45135399
131cAMP signaling pathway_Homo sapiens_hsa040240.44808606
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.44439832
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44212952
134Oxytocin signaling pathway_Homo sapiens_hsa049210.43862459
135FoxO signaling pathway_Homo sapiens_hsa040680.43488897
136Ras signaling pathway_Homo sapiens_hsa040140.42835755
137Mineral absorption_Homo sapiens_hsa049780.41875977
138Insulin secretion_Homo sapiens_hsa049110.41840194
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41623264
140VEGF signaling pathway_Homo sapiens_hsa043700.39698743
141Salivary secretion_Homo sapiens_hsa049700.39378090
142Glucagon signaling pathway_Homo sapiens_hsa049220.37750945
143p53 signaling pathway_Homo sapiens_hsa041150.37714898
144mRNA surveillance pathway_Homo sapiens_hsa030150.36434614
145mTOR signaling pathway_Homo sapiens_hsa041500.36134635

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